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SEH1L Gene

protein-coding   GIFtS: 55
GCID: GC18P012947

SEH1-Like (S. Cerevisiae)

  See SEH1L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SEH1-Like (S. Cerevisiae)1 2     SEC13-Like Protein2 3
SEC13L2 3 5     SEH13 5
Nucleoporin Seh11 2     SEH1A2
Sec13 Like Protein1 2     SEH1B2
Nup107-160 Subcomplex Subunit SEH12 3     Seh12

External Ids:    HGNC: 303791   Entrez Gene: 819292   Ensembl: ENSG000000854157   OMIM: 6092635   UniProtKB: Q96EE33   

Export aliases for SEH1L gene to outside databases

Previous GC identifers: GC18P012939 GC18P012901


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEH1L Gene:
The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats
and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the
Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively
spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for SEH1L Gene:
SEH1L (SEH1-like (S. cerevisiae)) is a protein-coding gene. Diseases associated with SEH1L include nail disease.

UniProtKB/Swiss-Prot: SEH1_HUMAN, Q96EE3
Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is
required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore
microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment
of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR2 complex, inhibits GATOR1 complex,
an inhibitor of the amino acid-sensing branch of the TORC1 pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010859.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEH1L gene promoter:
         Max1   AML1a   FOXL1   GATA-2   c-Ets-1   GATA-1   FOXO4   MRF-2   En-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEH1L promoter sequence
   Search Chromatin IP Primers for SEH1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEH1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.21

SEH1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEH1L gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P012947:  view genomic region     (about GC identifiers)

Start:
12,947,132 bp from pter      End:
12,987,535 bp from pter
Size:
40,404 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SEH1_HUMAN, Q96EE3 (See protein sequence)
Recommended Name: Nucleoporin SEH1  
Size: 360 amino acids; 39649 Da
Subunit: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex
includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. The SEH1 subunit appears to be only
weakly associated with the Nup107-160 subcomplex. Within the GATOR complex, component of the GATOR2 subcomplex,
made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and
RRAGB/RRAGC heterodimers
Secondary accessions: A8K5B1 Q8NFU6 Q96MH3 Q9C069
Alternative splicing: 2 isoforms:  Q96EE3-2   Q96EE3-1   (Contains a phosphoserine at position 365)

Explore the universe of human proteins at neXtProt for SEH1L: NX_Q96EE3

Explore proteomics data for SEH1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys96, Lys306, Lys314
  • Modification sites at PhosphoSitePlus

  • See SEH1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001013455.1  NP_112493.2  

    ENSEMBL proteins: 
     ENSP00000467605   ENSP00000262124   ENSP00000466959   ENSP00000382779   ENSP00000467276  
     ENSP00000466234  
    Reactome Protein details: Q96EE3

    SEH1L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96EE3

    ProtoNet protein and cluster: Q96EE3

    UniProtKB/Swiss-Prot: SEH1_HUMAN, Q96EE3
    Similarity: Belongs to the WD repeat SEC13 family
    Similarity: Contains 6 WD repeats


    Find genes that share domains with SEH1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEH1_HUMAN, Q96EE3
    Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is
    required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore
    microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment
    of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR2 complex, inhibits GATOR1 complex,
    an inhibitor of the amino acid-sensing branch of the TORC1 pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SEH1L           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SEH1L:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Seh1l):
     mortality/aging 

    Find genes that share phenotypes with SEH1L           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SEH1L

    miRNA
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    hsa-mir-210-3p (MIRT003158), hsa-mir-16-5p (MIRT031586)

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    Selected qRT-PCR Assays for microRNAs that regulate SEH1L (see all 25):
    hsa-miR-21* hsa-miR-4311 hsa-miR-520d-5p hsa-miR-15a hsa-miR-424 hsa-miR-508-5p hsa-miR-23a hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidSEH1L 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEH1_HUMAN, Q96EE3: Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776colocalizes with kinetochore IDA15146057
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005635nuclear envelope TAS--
    GO:0005829cytosol TAS--
    GO:0031080nuclear pore outer ring NAS15146057

    Find genes that share ontologies with SEH1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEH1L About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with SEH1L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for SEH1L (see all 9)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Pore Complex (NPC) Disassembly
    Nuclear import of Rev protein
    Resolution of Sister Chromatid Cohesion


    1 Kegg Pathway  (Kegg details for SEH1L):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEH1L
    Interactions:

        Search GeneGlobe Interaction Network for SEH1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEH1L (Q96EE32, 3 ENSP000003827794) via UniProtKB, MINT, STRING, and/or I2D (see all 931)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP155O756942, 3, ENSP000002314984MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000231498
    RBBP5Q152912, 3, ENSP000002645154MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000264515
    SNRNP200O756432, 3MINT-7945693 MINT-7947479 I2D: score=2 
    ARCN1P484442, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT4P509912, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006999nuclear pore organization IMP15146057
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0007080mitotic metaphase plate congression IMP17363900

    Find genes that share ontologies with SEH1L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SEH1L (SEH1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEH1L gene (2 alternative transcripts): 
    NM_001013437.1  NM_031216.3  

    Unigene Cluster for SEH1L:

    SEH1-like (S. cerevisiae)
    Hs.301048  [show with all ESTs]
    Unigene Representative Sequence: AK226075
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592170 ENST00000262124(uc002krr.3) ENST00000585730 ENST00000399892(uc002krq.3)
    ENST00000589446 ENST00000587761 ENST00000588251 ENST00000592582 ENST00000590843
    ENST00000590032
    miRNA
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    hsa-miR-21* hsa-miR-4311 hsa-miR-520d-5p hsa-miR-15a hsa-miR-424 hsa-miR-508-5p hsa-miR-23a hsa-miR-589
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    Additional mRNA sequence: 

    AF136976.1 AF255625.1 AF431970.1 AF514996.1 AK056940.1 AK226075.1 AK291226.1 AK314403.1 
    BC012430.1 

    10 DOTS entries:

    DT.454339  DT.100669516  DT.86858657  DT.100769841  DT.95277877  DT.100045767  DT.100737411  DT.100779898 
    DT.100779899  DT.92019238 

    Selected AceView cDNA sequences (see all 202):

    BM699492 BM839828 BQ431741 CA444644 AI819007 BC012430 BM556427 AI767625 
    CA427343 AW236400 CK431020 CR620641 Z45217 AF514996 AI040618 AA568797 
    AW576354 BM015734 BM967114 BQ226762 BU737231 AA329797 AI270438 CA429006 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEH1L (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12
    SP1:        -                                   -                                         -           -               
    SP2:        -                                   -                                         -           -     -         
    SP3:        -                                                                                                         
    SP4:        -           -                       -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for SEH1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEH1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTACAACC
    SEH1L Expression
    About this image

    SEH1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEH1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301048
        Custom PCR Arrays for SEH1L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEH1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEH1L gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Seh1l1 , 5 SEH1-like (S. cerevisiae1, 5 89.36(n)1
    96.08(a)1
      18 (40.10 cM)5
    721241  NM_001039088.11  NP_001034177.11 
     677748765 
    chicken
    (Gallus gallus)
    Aves SEH1L1 SEH1-like (S. cerevisiae) 85.04(n)
    93.56(a)
      100859886  XM_004939714.1  XP_004939771.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEH1L6
    SEH1-like (S. cerevisiae)
    90(a)
    1 ↔ 1
    4(42878056-42883744)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF284463.12   -- 80.91(n)    CF284463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY398414.12   -- 75.99(n)   334749  AY398414.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nup44A1 Nucleoporin 44A 57.36(n)
    57.66(a)
      35762  NM_165583.1  NP_724638.1 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-181 npp-18 52.67(n)
    44(a)
      176748  NM_067339.4  NP_499740.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEH1(YGL100W)4
    SEH11
    Nuclear pore protein of the conserved Nup84p complex more4
    SEH11
    50.79(n)1
    41.22(a)1
      7(313234-314283)4
    8527781, 4  NP_011415.11, 4 


    ENSEMBL Gene Tree for SEH1L (if available)
    TreeFam Gene Tree for SEH1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEH1L gene
    3 SIMAP similar genes for SEH1L using alignment to 5 protein entries:     SEH1_HUMAN (see all proteins):
    SEC13    ARPC1B    PF20

    Find genes that share paralogs with SEH1L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEH1L (see all 914)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153490611,2
    F--12933983(+) ACTCTT/GACAAT 2 -- int11Minor allele frequency- G:0.01WA 118
    rs1437904871,2
    --12934022(+) CTACCC/TAAAGG 2 -- int10--------
    rs1510876831,2
    --12934084(+) TTATTC/GATAAT 2 -- int10--------
    rs1818134261,2
    --12934167(+) GAATAC/TTATTC 2 -- int10--------
    rs1403077821,2
    --12946077(+) AGATTC/GCCATT 2 -- us2k10--------
    rs1872520101,2
    --12946106(+) GTCAAA/TACCAT 2 -- us2k10--------
    rs1453249771,2
    --12946209(+) CGCGTA/GATACT 2 -- us2k10--------
    rs756873031,2
    F--12946314(+) AATGAT/GGTGTC 2 -- us2k12Minor allele frequency- G:0.03NA EA 240
    rs771746341,2
    C,F--12946498(+) GTTTCA/CCCTAA 2 -- us2k14Minor allele frequency- C:0.06CSA WA EA 242
    rs1180601891,2
    C,F--12946519(+) CACTCC/TCACTC 2 -- us2k11Minor allele frequency- T:0.03EA 120

    HapMap Linkage Disequilibrium report for SEH1L (12947132 - 12987535 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SEH1L: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEH1L
    DNA2.0 Custom Variant and Variant Library Synthesis for SEH1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609263    OMIM disorders: --

    1 disease for SEH1L:    
    About MalaCards
    nail disease

    1 disease from the University of Copenhagen DISEASES database for SEH1L:
    Nail disease

    Find genes that share disorders with SEH1L           About GenesLikeMe


    Export disorders for SEH1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEH1L gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with SEH1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2, 3 Cronshaw J.M.... Matunis M.J. (J. Cell Biol. 2002)
    2. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. (PubMed id 17360435)1, 2 Glavy J.S.... Chait B.T. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    3. The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. (PubMed id 17363900)1, 2 Zuccolo M.... Doye V. (EMBO J. 2007)
    4. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. (PubMed id 15146057)1, 2 Loieodice I.... Doye V. (Mol. Biol. Cell 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex. (PubMed id 14517296)1, 3 Enninga J.... Fontoura B.M. (Mol. Cell. Biol. 2003)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. (PubMed id 23723238)2 Bar-Peled L....Sabatini D.M. (Science 2013)
    10. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81929 HGNC: 30379 AceView: SEH1L Ensembl:ENSG00000085415 euGenes: HUgn81929
    ECgene: SEH1L Kegg: 81929 H-InvDB: SEH1L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEH1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEH1L gene:
    Search GeneIP for patents involving SEH1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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