SECTM1 Gene
protein-coding GIFtS: 50
GCID: GC17M080278
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secreted and transmembrane 1
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Aliases
for SECTM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Secreted And Transmembrane 11 2 | | K121 2 3 5 | | Secreted And Transmembrane Protein 12 | | Type 1a Transmembrane Protein2 | | Protein K-123 |
Export aliases for SECTM1 gene to outside databasesPrevious GC identifers: GC17P079165 GC17M083193 GC17M080808 GC17M080957 GC17M077872 GC17M075677 |
Summaries
for SECTM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SECTM1:
This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It isfound in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SCTM1_HUMAN, Q8WVN6Function: May be involved in thymocyte signaling
Gene Wiki entry for SECTM1
|
Genomic Views
for SECTM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SECTM1 gene promoter:
GCNF HNF-4alpha2 HNF-4alpha1 MEF-2A IRF-2 GCNF-1 IRF-7A aMEF-2 GCNF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SECTM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SECTM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25SECTM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M080278: view genomic region
(about GC identifiers)
Start:
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80,278,900 bp from pter |
End:
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80,291,950 bp from pter |
Size:
|
13,051 bases |
Orientation:
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minus strand |
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Proteins
for SECTM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SCTM1_HUMAN, Q8WVN6 (See
protein sequence)Recommended Name: Secreted and transmembrane protein 1 precursor Size: 248 amino acids; 27039 Da
Subunit: Interacts with CD7
Subcellular location: Cell membrane; Single-pass type I membrane protein (Probable). Secreted
Secondary accessions: B2R7H0 O00466Explore the universe of human proteins at neXtProt for SECTM1: NX_Q8WVN6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVN6
SECTM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002995.1
ENSEMBL proteins: ENSP00000269389 ENSP00000463904 ENSP00000464111 ENSP00000463114 ENSP00000463120 ENSP00000462563 ENSP00000462294 ENSP00000464385
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SECTM1 for ontologies About GeneDecksing
SECTM1 Antibody Products:
Assay Products for SECTM1: |
Protein
Domains /
Families
for SECTM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8WVN6 UniProtKB/Swiss-Prot: SCTM1_HUMAN, Q8WVN6Similarity: Belongs to the SECTM family |
Function
for SECTM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SCTM1_HUMAN, Q8WVN6Function: May be involved in thymocyte signalingInduction: By IFNG/IFN-gamma (at protein level) Genatlas biochemistry entry for SECTM1:Golgi-associated protein,expressed in breast cancer cell lines and peripheral blood leucocyte,upstream of CD7
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SECTM1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SECTM1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SECTM1 (NM_003004) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SECTM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECTM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECTM1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SECTM1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SECTM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SECTM1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SECTM1 (Q8WVN63 ENSP000002693894) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SECTM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SECTM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SECTM1
Search CenterWatch for drugs/clinical trials and news about SECTM1 / SCTM1
|
Transcripts
for SECTM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SECTM1 gene: NM_003004.2 Unigene Cluster for SECTM1: Secreted and transmembrane 1 Hs.558009 [show with all ESTs]Unigene Representative Sequence: NM_0030048 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269389(uc002keo.3) ENST00000580437 ENST00000581864 ENST00000581691
ENST00000582563 ENST00000583093 ENST00000582290 ENST00000581954
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SECTM1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SECTM1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SECTM1 (NM_003004) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SECTM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECTM1 |
Additional cDNA sequence: AK223068.1 AK223104.1 AK290708.1 AK312980.1 BC017716.1 U77643.1 7 DOTS entries: DT.403344 DT.120937834 DT.100720762 DT.100806701 DT.100806712 DT.100806710 DT.95113527 24/130 AceView cDNA sequences (see all 130): BX417901 CK903980 CR595956 CD364677 CR594118 BF002304 CR594943 BQ946621 CR606594 BM755524 AW057702 BU689727 AA826896 CF140805 BX399171 CR591775 BM053069 BF939675 CR625551 CR614987 AW002382 BI761265 CR620624 BX396113
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SECTM1 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for SECTM1
|
Expression
for SECTM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SECTM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCGAATAT
About this image
See SECTM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SECTM1
SOURCE GeneReport for Unigene cluster: Hs.558009
UniProtKB/Swiss-Prot: SCTM1_HUMAN, Q8WVN6Tissue specificity: Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Foundin leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectableexpression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts
SABiosciences Expression via Pathway-Focused PCR Array including SECTM1: | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SECTM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SECTM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SECTM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SECTM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECTM1 |
Orthologs
for SECTM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SECTM1 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for SECTM1 (if available)
TreeFam Gene Tree for SECTM1 (if available) |
Paralogs
for SECTM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SECTM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SECTM1 (80278900 - 80291950 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SECTM1
2 CNVs: 5043 73078 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SECTM1 |
|
Disorders
/ Diseases
for SECTM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SECTM1 for disorders About GeneDecksing
OMIM gene information: 602602
OMIM disorders: --
7  diseases for SECTM1: About MalaCardsulceroglandular tularemia tularemia corneal dystrophy shigellosis
meningioma breast cancer leukemia
1 disease from the University of Copenhagen DISEASES database for SECTM1:Corneal dystrophy Human Genome Epidemiology (HuGE) Navigator: SECTM1 (4 documents)
Export disorders for SECTM1 gene to outside databases
|
Publications
for SECTM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SECTM1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SECTM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. (PubMed id 9480746)1, 2, 3, 9 Slentz-Kesler K.A.... Kaufman R.E. (1998)
- Identification of CD7 as a cognate of the human K12 (SECTM1) protein. (PubMed id 10652336)1, 2, 9 Lyman S.D.... Fanslow W.C. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma. (PubMed id 15742156)2, 9 Lam G.K....Haynes B.F. (2005)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The T/NK cell co-stimulatory molecule SECTM1 is an IF N 'early response gene' that is negatively regulated by LPS in human monocytic cells. (PubMed id 21749909)1 Huyton T....Blasczyk R. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1 Han S....Kang D. (2010)
- Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1 Rajaraman P....Inskip P.D. (2010)
- Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (2009)
|
External Searches for SECTM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SECTM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SECTM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SECTM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SECTM1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SECTM1 gene:
Search GeneIP for patents involving SECTM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SECTM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SECTM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SECTM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SECTM1 | | | OriGene Protein Over-expression Lysate for SECTM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SECTM1 | | OriGene 3'-UTR Clone for SECTM1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SECTM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SECTM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SECTM1 | | OriGene Custom Protein Services for SECTM1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SECTM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SECTM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SECTM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SECTM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SECTM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SECTM1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SECTM1 |
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 | | | SECTM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECTM1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SECTM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECTM1 |
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