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Aliases for SECTM1 Gene

Aliases for SECTM1 Gene

  • Secreted And Transmembrane 1 2 3 5
  • Type 1a Transmembrane Protein 2 3
  • K12 3 4
  • Secreted And Transmembrane Protein 1 3
  • Protein K-12 4
  • K12 Protein 2

External Ids for SECTM1 Gene

Previous GeneCards Identifiers for SECTM1 Gene

  • GC17P079165
  • GC17M083193
  • GC17M080808
  • GC17M080957
  • GC17M077872
  • GC17M080278
  • GC17M075677

Summaries for SECTM1 Gene

Entrez Gene Summary for SECTM1 Gene

  • This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]

GeneCards Summary for SECTM1 Gene

SECTM1 (Secreted And Transmembrane 1) is a Protein Coding gene. Diseases associated with SECTM1 include Ulceroglandular Tularemia. GO annotations related to this gene include signal transducer activity and cytokine activity.

UniProtKB/Swiss-Prot for SECTM1 Gene

  • May be involved in thymocyte signaling.

Gene Wiki entry for SECTM1 Gene

Additional gene information for SECTM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SECTM1 Gene

Genomics for SECTM1 Gene

Regulatory Elements for SECTM1 Gene

Enhancers for SECTM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H082332 1.6 FANTOM5 ENCODE dbSUPER 52.1 +0.2 151 3.7 HDGF PKNOX1 ATF1 FOXA2 ARNT SIN3A TCF12 GLIS2 ATF7 SP3 SECTM1 TBCD TEX19 CCDC57 GPS1 ENSG00000263321 ENSG00000265678 ARL16 RFNG ENSG00000260011
GH17H082492 2.1 FANTOM5 Ensembl ENCODE dbSUPER 26.9 -161.4 -161419 6 ZFP64 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 MEF2D TBCD HGS NARF ALYREF ENSG00000260563 GPS1 ARL2BPP9 FOXK2 NARF-IT1 ENSG00000262652
GH17H082291 2.1 FANTOM5 Ensembl ENCODE dbSUPER 16.4 +35.4 35441 14.7 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC CSNK1D HGS ENSG00000260563 NARF-IT1 ALYREF FAAP100 TEX19 ENSG00000262652 ARL2BPP9 DUS1L
GH17H082204 2 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +128.2 128157 3.6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 FOS CCDC57 SLC16A3 SECTM1 CSNK1D NARF C17orf62 SIRT7 MAFG GC17M082163
GH17H082533 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -202.5 -202525 6 HDAC1 ARID4B ZEB1 ZNF366 ZSCAN5C FOS ATF7 KLF7 ZNF680 ZNF362 NARF C17orf62 TEX19 SECTM1 FOXK2 ENSG00000264812 GC17M082549
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SECTM1 on UCSC Golden Path with GeneCards custom track

Promoters for SECTM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099583 174 601 STAT1 SP3 KLF1 ARNT SP2 KLF17 ZSCAN21 ZFP69B ZNF692 GLIS1

Genomic Locations for SECTM1 Gene

Genomic Locations for SECTM1 Gene
13,051 bases
Minus strand

Genomic View for SECTM1 Gene

Genes around SECTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SECTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SECTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SECTM1 Gene

Proteins for SECTM1 Gene

  • Protein details for SECTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secreted and transmembrane protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R7H0
    • O00466

    Protein attributes for SECTM1 Gene

    248 amino acids
    Molecular mass:
    27039 Da
    Quaternary structure:
    • Interacts with CD7.

neXtProt entry for SECTM1 Gene

Post-translational modifications for SECTM1 Gene

  • Ubiquitination at Lys181
  • Glycosylation at isoforms=56
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SECTM1 Gene

Domains & Families for SECTM1 Gene

Gene Families for SECTM1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SECTM1 Gene


Suggested Antigen Peptide Sequences for SECTM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SECTM family.
  • Belongs to the SECTM family.
genes like me logo Genes that share domains with SECTM1: view

Function for SECTM1 Gene

Molecular function for SECTM1 Gene

GENATLAS Biochemistry:
Golgi-associated protein,expressed in breast cancer cell lines and peripheral blood leucocyte,upstream of CD7
UniProtKB/Swiss-Prot Function:
May be involved in thymocyte signaling.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma (at protein level).

Phenotypes From GWAS Catalog for SECTM1 Gene

Gene Ontology (GO) - Molecular Function for SECTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with SECTM1: view

Phenotypes for SECTM1 Gene

genes like me logo Genes that share phenotypes with SECTM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SECTM1 Gene

Localization for SECTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SECTM1 Gene

Cell membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SECTM1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for SECTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 9480746
GO:0005794 Golgi apparatus TAS 9480746
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SECTM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SECTM1 Gene

Pathways & Interactions for SECTM1 Gene

SuperPathways for SECTM1 Gene

No Data Available

Interacting Proteins for SECTM1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000269389 Q8WVN6-SCTM1_HUMAN for SECTM1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SECTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
GO:0007498 mesoderm development TAS 9480746
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with SECTM1: view

No data available for Pathways by source and SIGNOR curated interactions for SECTM1 Gene

Drugs & Compounds for SECTM1 Gene

No Compound Related Data Available

Transcripts for SECTM1 Gene

Unigene Clusters for SECTM1 Gene

Secreted and transmembrane 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SECTM1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: -
SP10: - - -
SP11: - -

Relevant External Links for SECTM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SECTM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SECTM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SECTM1 Gene

This gene is overexpressed in Whole Blood (x26.2).

Protein differential expression in normal tissues from HIPED for SECTM1 Gene

This gene is overexpressed in Urine (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SECTM1 Gene

Protein tissue co-expression partners for SECTM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SECTM1 Gene:


SOURCE GeneReport for Unigene cluster for SECTM1 Gene:


mRNA Expression by UniProt/SwissProt for SECTM1 Gene:

Tissue specificity: Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts.

Evidence on tissue expression from TISSUES for SECTM1 Gene

  • Liver(4.1)
  • Intestine(2.8)
genes like me logo Genes that share expression patterns with SECTM1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SECTM1 Gene

Orthologs for SECTM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SECTM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SECTM1 33 34
  • 93.02 (n)
(Rattus norvegicus)
Mammalia Sectm1 33
  • 71.15 (n)
(Mus musculus)
Mammalia Sectm1a 33 16 34
  • 65.13 (n)
Sectm1b 34
  • 34 (a)
(Bos Taurus)
Mammalia -- 34
  • 37 (a)
-- 34
  • 36 (a)
SECTM1 34 34
  • 31 (a)
-- 34
  • 30 (a)
Species where no ortholog for SECTM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SECTM1 Gene

Gene Tree for SECTM1 (if available)
Gene Tree for SECTM1 (if available)

Paralogs for SECTM1 Gene

No data available for Paralogs for SECTM1 Gene

Variants for SECTM1 Gene

Sequence variations from dbSNP and Humsavar for SECTM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000048831 -- 82,328,139(+) GCTGC(A/T)CTCAC intron-variant, utr-variant-5-prime
rs1000262018 -- 82,331,010(+) CCTCC(C/G)TTCCT intron-variant
rs1000293046 -- 82,330,820(+) GGAGA(A/G)GGGGG intron-variant
rs1000504797 -- 82,334,501(+) GGGCA(C/T)GCGGG upstream-variant-2KB
rs1000625091 -- 82,335,321(+) AACTG(C/T)TGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SECTM1 Gene

Variant ID Type Subtype PubMed ID
nsv952394 CNV deletion 24416366
nsv833573 CNV loss 17160897
nsv833572 CNV loss 17160897
nsv469561 CNV loss 16826518
nsv428351 CNV gain 18775914
nsv1067194 CNV gain 25217958
nsv1059334 CNV gain 25217958
esv2762577 CNV gain+loss 21179565
esv2760445 CNV gain 21179565
esv21913 CNV gain+loss 19812545
esv1009380 CNV insertion 20482838

Variation tolerance for SECTM1 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SECTM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SECTM1 Gene

Disorders for SECTM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SECTM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ulceroglandular tularemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SECTM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SECTM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SECTM1 Gene

Publications for SECTM1 Gene

  1. Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. (PMID: 9480746) Slentz-Kesler KA … Kaufman RE (Genomics 1998) 2 3 4 22 60
  2. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. (PMID: 10652336) Lyman SD … Fanslow WC (The Journal of biological chemistry 2000) 3 4 22 60
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 45 60
  5. Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma. (PMID: 15742156) Lam GK … Haynes BF (Journal of clinical immunology 2005) 4 22 60

Products for SECTM1 Gene

Sources for SECTM1 Gene

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