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Aliases for SECTM1 Gene

Aliases for SECTM1 Gene

  • Secreted And Transmembrane 1 2 3 5
  • Type 1a Transmembrane Protein 2 3
  • K12 3 4
  • Protein K-12 4
  • K12 Protein 2

External Ids for SECTM1 Gene

Previous GeneCards Identifiers for SECTM1 Gene

  • GC17P079165
  • GC17M083193
  • GC17M080808
  • GC17M080957
  • GC17M077872
  • GC17M080278
  • GC17M075677

Summaries for SECTM1 Gene

Entrez Gene Summary for SECTM1 Gene

  • This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]

GeneCards Summary for SECTM1 Gene

SECTM1 (Secreted And Transmembrane 1) is a Protein Coding gene. Diseases associated with SECTM1 include Ulceroglandular Tularemia. Among its related pathways are TNF Signaling (sino). GO annotations related to this gene include signal transducer activity and cytokine activity.

UniProtKB/Swiss-Prot for SECTM1 Gene

  • May be involved in thymocyte signaling.

Gene Wiki entry for SECTM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SECTM1 Gene

Genomics for SECTM1 Gene

Regulatory Elements for SECTM1 Gene

Enhancers for SECTM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SECTM1 on UCSC Golden Path with GeneCards custom track

Promoters for SECTM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SECTM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SECTM1 Gene

Chromosome:
17
Start:
82,321,024 bp from pter
End:
82,334,074 bp from pter
Size:
13,051 bases
Orientation:
Minus strand

Genomic View for SECTM1 Gene

Genes around SECTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SECTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SECTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SECTM1 Gene

Proteins for SECTM1 Gene

  • Protein details for SECTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVN6-SCTM1_HUMAN
    Recommended name:
    Secreted and transmembrane protein 1
    Protein Accession:
    Q8WVN6
    Secondary Accessions:
    • B2R7H0
    • O00466

    Protein attributes for SECTM1 Gene

    Size:
    248 amino acids
    Molecular mass:
    27039 Da
    Quaternary structure:
    • Interacts with CD7.

neXtProt entry for SECTM1 Gene

Proteomics data for SECTM1 Gene at MOPED

Post-translational modifications for SECTM1 Gene

Antibody Products

No data available for DME Specific Peptides for SECTM1 Gene

Domains & Families for SECTM1 Gene

Protein Domains for SECTM1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SECTM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVN6

UniProtKB/Swiss-Prot:

SCTM1_HUMAN :
  • Belongs to the SECTM family.
Family:
  • Belongs to the SECTM family.
genes like me logo Genes that share domains with SECTM1: view

No data available for Gene Families for SECTM1 Gene

Function for SECTM1 Gene

Molecular function for SECTM1 Gene

GENATLAS Biochemistry:
Golgi-associated protein,expressed in breast cancer cell lines and peripheral blood leucocyte,upstream of CD7
UniProtKB/Swiss-Prot Function:
May be involved in thymocyte signaling.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma (at protein level).

Gene Ontology (GO) - Molecular Function for SECTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with SECTM1: view

Phenotypes for SECTM1 Gene

genes like me logo Genes that share phenotypes with SECTM1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SECTM1 Gene

Localization for SECTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SECTM1 Gene

Cell membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SECTM1 Gene COMPARTMENTS Subcellular localization image for SECTM1 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SECTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SECTM1: view

Pathways & Interactions for SECTM1 Gene

SuperPathways for SECTM1 Gene

Superpath Contained pathways
1 TNF Signaling (sino)
genes like me logo Genes that share pathways with SECTM1: view

Pathways by source for SECTM1 Gene

1 Sino Biological pathway for SECTM1 Gene

Interacting Proteins for SECTM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269389%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000312027%0d%0a
Selected Interacting proteins: ENSP00000269389 Q8WVN6-SCTM1_HUMAN for SECTM1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SECTM1 Gene

None

No data available for SIGNOR curated interactions for SECTM1 Gene

Drugs & Compounds for SECTM1 Gene

No Compound Related Data Available

Transcripts for SECTM1 Gene

Unigene Clusters for SECTM1 Gene

Secreted and transmembrane 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SECTM1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: -
SP9:
SP10: - - -
SP11: - -

Relevant External Links for SECTM1 Gene

GeneLoc Exon Structure for
SECTM1
ECgene alternative splicing isoforms for
SECTM1

Expression for SECTM1 Gene

mRNA expression in normal human tissues for SECTM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SECTM1 Gene

This gene is overexpressed in Whole Blood (x26.2).

Protein differential expression in normal tissues from HIPED for SECTM1 Gene

This gene is overexpressed in Urine (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SECTM1 Gene



SOURCE GeneReport for Unigene cluster for SECTM1 Gene Hs.558009

mRNA Expression by UniProt/SwissProt for SECTM1 Gene

Q8WVN6-SCTM1_HUMAN
Tissue specificity: Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts.
genes like me logo Genes that share expression patterns with SECTM1: view

Protein tissue co-expression partners for SECTM1 Gene

- Elite partner

Primer Products

Orthologs for SECTM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SECTM1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Sectm1a 35
  • 65.13 (n)
  • 47.98 (a)
Sectm1a 16
Sectm1a 36
  • 39 (a)
OneToMany
Sectm1b 36
  • 34 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SECTM1 35
  • 93.02 (n)
  • 91.22 (a)
SECTM1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sectm1 35
  • 71.15 (n)
  • 55.46 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 30 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
SECTM1 36
  • 31 (a)
OneToMany
SECTM1 36
  • 37 (a)
OneToMany
Species with no ortholog for SECTM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SECTM1 Gene

ENSEMBL:
Gene Tree for SECTM1 (if available)
TreeFam:
Gene Tree for SECTM1 (if available)

Paralogs for SECTM1 Gene

No data available for Paralogs for SECTM1 Gene

Variants for SECTM1 Gene

Sequence variations from dbSNP and Humsavar for SECTM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1132114 -- 82,321,552(-) GACGC(C/T)GCCCT utr-variant-3-prime
rs1132115 -- 82,321,536(-) GCTGG(A/T)CGCGC utr-variant-3-prime
rs4452007 -- 82,325,194(-) GAAAT(A/G)TACAG intron-variant
rs5822518 -- 82,325,103(+) GTGTA(-/TG)TGTGT intron-variant
rs6502097 -- 82,328,303(+) GGCCC(C/G)ACAGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SECTM1 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3341n71 CNV Loss 21882294
dgv3353n71 CNV Loss 21882294
dgv3354n71 CNV Loss 21882294
nsv833572 CNV Loss 17160897
dgv3355n71 CNV Loss 21882294
nsv909208 CNV Loss 21882294
nsv469561 CNV Complex 16826518
dgv3356n71 CNV Loss 21882294
nsv909217 CNV Loss 21882294
nsv833573 CNV Loss 17160897
dgv3357n71 CNV Loss 21882294
nsv909220 CNV Loss 21882294
dgv3358n71 CNV Loss 21882294
nsv909223 CNV Loss 21882294
esv1009380 CNV Insertion 20482838

Variation tolerance for SECTM1 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SECTM1 Gene

Disorders for SECTM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SECTM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ulceroglandular tularemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SECTM1

Genetic Association Database (GAD)
SECTM1
Human Genome Epidemiology (HuGE) Navigator
SECTM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SECTM1
genes like me logo Genes that share disorders with SECTM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SECTM1 Gene

Publications for SECTM1 Gene

  1. Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. (PMID: 9480746) Slentz-Kesler K.A. … Kaufman R.E. (Genomics 1998) 2 3 4 23 67
  2. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. (PMID: 10652336) Lyman S.D. … Fanslow W.C. (J. Biol. Chem. 2000) 3 23
  3. SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. (PMID: 24157461) Wang T. … Kaufman R.E. (J. Invest. Dermatol. 2014) 3
  4. Autocrine GM-CSF transcription in the leukemic progenitor cell line KG1a is mediated by the transcription factor ETS1 and is negatively regulated through SECTM1 mediated ligation of CD7. (PMID: 24211252) Bade-DAPding C. … Huyton T. (Biochim. Biophys. Acta 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for SECTM1 Gene

Sources for SECTM1 Gene

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