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Aliases for SECISBP2L Gene

Aliases for SECISBP2L Gene

  • SECIS Binding Protein 2 Like 2 3
  • SECIS Binding Protein 2-Like 3 5
  • SECIS-Binding Protein 2-Like 3 4
  • KIAA0256 4
  • SBP2L 3
  • SLAN 3

External Ids for SECISBP2L Gene

Previous GeneCards Identifiers for SECISBP2L Gene

  • GC15M047069
  • GC15M049280
  • GC15M026112

Summaries for SECISBP2L Gene

GeneCards Summary for SECISBP2L Gene

SECISBP2L (SECIS Binding Protein 2 Like) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is SECISBP2.

UniProtKB/Swiss-Prot for SECISBP2L Gene

  • Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SECISBP2L Gene

Genomics for SECISBP2L Gene

Regulatory Elements for SECISBP2L Gene

Enhancers for SECISBP2L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SECISBP2L on UCSC Golden Path with GeneCards custom track

Promoters for SECISBP2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SECISBP2L on UCSC Golden Path with GeneCards custom track

Genomic Location for SECISBP2L Gene

Chromosome:
15
Start:
48,988,476 bp from pter
End:
49,046,563 bp from pter
Size:
58,088 bases
Orientation:
Minus strand

Genomic View for SECISBP2L Gene

Genes around SECISBP2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SECISBP2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SECISBP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SECISBP2L Gene

Proteins for SECISBP2L Gene

  • Protein details for SECISBP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93073-SBP2L_HUMAN
    Recommended name:
    Selenocysteine insertion sequence-binding protein 2-like
    Protein Accession:
    Q93073
    Secondary Accessions:
    • Q8N767

    Protein attributes for SECISBP2L Gene

    Size:
    1101 amino acids
    Molecular mass:
    121776 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13386.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SECISBP2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SECISBP2L Gene

Proteomics data for SECISBP2L Gene at MOPED

Post-translational modifications for SECISBP2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SECISBP2L Gene

No data available for DME Specific Peptides for SECISBP2L Gene

Domains & Families for SECISBP2L Gene

Protein Domains for SECISBP2L Gene

Suggested Antigen Peptide Sequences for SECISBP2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SECISBP2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SECISBP2L Gene

Function for SECISBP2L Gene

Molecular function for SECISBP2L Gene

UniProtKB/Swiss-Prot Function:
Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.

Gene Ontology (GO) - Molecular Function for SECISBP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SECISBP2L: view
genes like me logo Genes that share phenotypes with SECISBP2L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SECISBP2L Gene

Localization for SECISBP2L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SECISBP2L Gene COMPARTMENTS Subcellular localization image for SECISBP2L gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SECISBP2L Gene

Pathways & Interactions for SECISBP2L Gene

SuperPathways for SECISBP2L Gene

No Data Available

Interacting Proteins for SECISBP2L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000453854%0d%0a9606.ENSP00000240343%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000453854 Q93073-SBP2L_HUMAN for SECISBP2L Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for SECISBP2L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SECISBP2L Gene

Drugs & Compounds for SECISBP2L Gene

No Compound Related Data Available

Transcripts for SECISBP2L Gene

Unigene Clusters for SECISBP2L Gene

SECIS binding protein 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SECISBP2L Gene

No ASD Table

Relevant External Links for SECISBP2L Gene

GeneLoc Exon Structure for
SECISBP2L
ECgene alternative splicing isoforms for
SECISBP2L

Expression for SECISBP2L Gene

mRNA expression in normal human tissues for SECISBP2L Gene

mRNA differential expression in normal tissues according to GTEx for SECISBP2L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for SECISBP2L Gene

This gene is overexpressed in Plasma (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SECISBP2L Gene



SOURCE GeneReport for Unigene cluster for SECISBP2L Gene Hs.9997

genes like me logo Genes that share expression patterns with SECISBP2L: view

Protein tissue co-expression partners for SECISBP2L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SECISBP2L Gene

Orthologs for SECISBP2L Gene

This gene was present in the common ancestor of animals.

Orthologs for SECISBP2L Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SECISBP2L 35
  • 93.77 (n)
  • 94.9 (a)
SECISBP2L 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Secisbp2l 35
  • 84.97 (n)
  • 88.15 (a)
Secisbp2l 16
Secisbp2l 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SECISBP2L 35
  • 99.76 (n)
  • 99.82 (a)
SECISBP2L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Secisbp2l 35
  • 85.45 (n)
  • 88.81 (a)
cow
(Bos Taurus)
Mammalia SECISBP2L 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SECISBP2L 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SECISBP2L 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SECISBP2L 35
  • 78.75 (n)
  • 82.14 (a)
SECISBP2L 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SECISBP2L 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia secisbp2l 35
  • 70.65 (n)
  • 71.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13483 35
zebrafish
(Danio rerio)
Actinopterygii secisbp2l 35
  • 61.21 (n)
  • 61.65 (a)
SECISBP2L 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sbp2 36
  • 30 (a)
OneToMany
Species with no ortholog for SECISBP2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SECISBP2L Gene

ENSEMBL:
Gene Tree for SECISBP2L (if available)
TreeFam:
Gene Tree for SECISBP2L (if available)

Paralogs for SECISBP2L Gene

Paralogs for SECISBP2L Gene

(2) SIMAP similar genes for SECISBP2L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SECISBP2L: view

Variants for SECISBP2L Gene

Sequence variations from dbSNP and Humsavar for SECISBP2L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs5812470 -- 48,996,683(+) GTCAG(-/AC)ACACT intron-variant
rs5812473 -- 49,043,623(+) GCAAG(-/T)TTTTT intron-variant
rs6493346 -- 49,022,279(+) tgccT(G/T)CCTTA intron-variant
rs6493347 -- 49,043,963(+) AAAAG(C/T)GTTTT intron-variant
rs11856781 -- 49,043,918(+) aaGGT(A/G)ATTCA intron-variant

Variation tolerance for SECISBP2L Gene

Residual Variation Intolerance Score: 7.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.46; 82.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SECISBP2L Gene

Disorders for SECISBP2L Gene

Relevant External Links for SECISBP2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SECISBP2L

No disorders were found for SECISBP2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SECISBP2L Gene

Publications for SECISBP2L Gene

  1. Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression. (PMID: 22530054) Donovan J. … Copeland P.R. (PLoS ONE 2012) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SECISBP2L Gene

Sources for SECISBP2L Gene

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