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Aliases for SECISBP2L Gene

Aliases for SECISBP2L Gene

  • SECIS Binding Protein 2 Like 2 3 5
  • Selenocysteine Insertion Sequence-Binding Protein 2-Like 3
  • SECIS-Binding Protein 2-Like 4
  • KIAA0256 4
  • SBP2L 3
  • SLAN 3

External Ids for SECISBP2L Gene

Previous GeneCards Identifiers for SECISBP2L Gene

  • GC15M047069
  • GC15M049280
  • GC15M026112

Summaries for SECISBP2L Gene

GeneCards Summary for SECISBP2L Gene

SECISBP2L (SECIS Binding Protein 2 Like) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is SECISBP2.

UniProtKB/Swiss-Prot for SECISBP2L Gene

  • Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SECISBP2L Gene

Genomics for SECISBP2L Gene

Regulatory Elements for SECISBP2L Gene

Enhancers for SECISBP2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G049169 1.1 ENCODE 10.7 -124.4 -124374 3.4 HDGF PKNOX1 CREB3L1 ARNT SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 SECISBP2L GALK2 FGF7 FAM227B MIR4716 RPL15P19
GH15G049154 1.1 ENCODE 10.7 -109.1 -109106 3.1 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ENSG00000259488 DUT SECISBP2L FAM227B DTWD1 COPS2 NDUFAF4P1
GH15G049421 1.3 Ensembl ENCODE dbSUPER 9 -377.3 -377300 3.8 TBP ARNT ZSCAN4 DNMT3B ZNF2 RAD21 CHAMP1 ZNF366 ZNF654 ELF1 FGF7 SECISBP2L GALK2 ENSG00000259715 LOC105370811
GH15G049133 1 Ensembl ENCODE 10.8 -90.0 -90012 5.2 MXI1 JUN BRCA1 RAD21 ZBTB40 YY1 RFX5 ZNF316 GATA2 SCRT2 SECISBP2L SHC4 FGF7 GALK2 FAM227B GC15M049139 ENSG00000200120 GC15M049107
GH15G049234 1 Ensembl ENCODE 10.3 -189.1 -189082 1.4 CTCF ZNF654 FOXA2 REST SUPT20H RAD21 ATF2 RFX5 ZNF664 GATA2 SECISBP2L FAM227B PIR52968 RN7SL307P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SECISBP2L on UCSC Golden Path with GeneCards custom track

Promoters for SECISBP2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076304 863 2601 MLX AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for SECISBP2L Gene

Chromosome:
15
Start:
48,988,476 bp from pter
End:
49,046,563 bp from pter
Size:
58,088 bases
Orientation:
Minus strand

Genomic View for SECISBP2L Gene

Genes around SECISBP2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SECISBP2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SECISBP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SECISBP2L Gene

Proteins for SECISBP2L Gene

  • Protein details for SECISBP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93073-SBP2L_HUMAN
    Recommended name:
    Selenocysteine insertion sequence-binding protein 2-like
    Protein Accession:
    Q93073
    Secondary Accessions:
    • Q8N767

    Protein attributes for SECISBP2L Gene

    Size:
    1101 amino acids
    Molecular mass:
    121776 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13386.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SECISBP2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SECISBP2L Gene

Post-translational modifications for SECISBP2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SECISBP2L Gene

No data available for DME Specific Peptides for SECISBP2L Gene

Domains & Families for SECISBP2L Gene

Protein Domains for SECISBP2L Gene

Suggested Antigen Peptide Sequences for SECISBP2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SECISBP2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SECISBP2L Gene

Function for SECISBP2L Gene

Molecular function for SECISBP2L Gene

UniProtKB/Swiss-Prot Function:
Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.

Gene Ontology (GO) - Molecular Function for SECISBP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003730 mRNA 3-UTR binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0035368 selenocysteine insertion sequence binding IBA --
GO:0043021 ribonucleoprotein complex binding IBA --
genes like me logo Genes that share ontologies with SECISBP2L: view
genes like me logo Genes that share phenotypes with SECISBP2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SECISBP2L Gene

Localization for SECISBP2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SECISBP2L gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SECISBP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030529 intracellular ribonucleoprotein complex IBA --
genes like me logo Genes that share ontologies with SECISBP2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SECISBP2L Gene

Pathways & Interactions for SECISBP2L Gene

SuperPathways for SECISBP2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SECISBP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation IBA --
genes like me logo Genes that share ontologies with SECISBP2L: view

No data available for Pathways by source and SIGNOR curated interactions for SECISBP2L Gene

Drugs & Compounds for SECISBP2L Gene

No Compound Related Data Available

Transcripts for SECISBP2L Gene

Unigene Clusters for SECISBP2L Gene

SECIS binding protein 2-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SECISBP2L Gene

No ASD Table

Relevant External Links for SECISBP2L Gene

GeneLoc Exon Structure for
SECISBP2L
ECgene alternative splicing isoforms for
SECISBP2L

Expression for SECISBP2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SECISBP2L Gene

mRNA differential expression in normal tissues according to GTEx for SECISBP2L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for SECISBP2L Gene

This gene is overexpressed in Plasma (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SECISBP2L Gene



Protein tissue co-expression partners for SECISBP2L Gene

NURSA nuclear receptor signaling pathways regulating expression of SECISBP2L Gene:

SECISBP2L

SOURCE GeneReport for Unigene cluster for SECISBP2L Gene:

Hs.9997

Evidence on tissue expression from TISSUES for SECISBP2L Gene

  • Nervous system(3.5)
  • Spleen(2.7)
  • Lymph node(2.4)
genes like me logo Genes that share expression patterns with SECISBP2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SECISBP2L Gene

Orthologs for SECISBP2L Gene

This gene was present in the common ancestor of animals.

Orthologs for SECISBP2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SECISBP2L 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia SECISBP2L 34 35
  • 93.77 (n)
rat
(Rattus norvegicus)
Mammalia Secisbp2l 34
  • 85.45 (n)
mouse
(Mus musculus)
Mammalia Secisbp2l 34 16 35
  • 84.97 (n)
oppossum
(Monodelphis domestica)
Mammalia SECISBP2L 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SECISBP2L 35
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SECISBP2L 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves SECISBP2L 34 35
  • 78.75 (n)
lizard
(Anolis carolinensis)
Reptilia SECISBP2L 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia secisbp2l 34
  • 70.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13483 34
zebrafish
(Danio rerio)
Actinopterygii secisbp2l 34
  • 61.21 (n)
SECISBP2L 35
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sbp2 35
  • 30 (a)
OneToMany
Species where no ortholog for SECISBP2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SECISBP2L Gene

ENSEMBL:
Gene Tree for SECISBP2L (if available)
TreeFam:
Gene Tree for SECISBP2L (if available)

Paralogs for SECISBP2L Gene

Paralogs for SECISBP2L Gene

(2) SIMAP similar genes for SECISBP2L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SECISBP2L: view

Variants for SECISBP2L Gene

Sequence variations from dbSNP and Humsavar for SECISBP2L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000083169 -- 49,000,806(+) TATGG(C/T)TTCTA intron-variant
rs1000096902 -- 49,004,253(+) TGATG(C/G)CAGTT intron-variant
rs1000112441 -- 49,045,869(+) ACACA(C/T)TCTCT intron-variant
rs1000122052 -- 49,009,400(+) TGAAG(A/G)GAAAA intron-variant
rs1000177063 -- 49,034,743(+) CACTG(C/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SECISBP2L Gene

Variant ID Type Subtype PubMed ID
nsv476989 CNV novel sequence insertion 20440878
nsv952622 CNV duplication 24416366

Variation tolerance for SECISBP2L Gene

Residual Variation Intolerance Score: 7.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.46; 82.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SECISBP2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SECISBP2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SECISBP2L Gene

Disorders for SECISBP2L Gene

Relevant External Links for SECISBP2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SECISBP2L

No disorders were found for SECISBP2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SECISBP2L Gene

Publications for SECISBP2L Gene

  1. Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression. (PMID: 22530054) Donovan J. … Copeland P.R. (PLoS ONE 2012) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen V.A. … Brummelkamp T.R. (Science 2015) 3 64

Products for SECISBP2L Gene

Sources for SECISBP2L Gene

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