Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SECISBP2L Gene

Aliases for SECISBP2L Gene

  • SECIS Binding Protein 2-Like 2 3
  • SECIS-Binding Protein 2-Like 3 4
  • Selenocysteine Insertion Sequence-Binding Protein 2-Like 3
  • KIAA0256 4
  • SBP2L 3
  • SLAN 3

External Ids for SECISBP2L Gene

Previous GeneCards Identifiers for SECISBP2L Gene

  • GC15M047069
  • GC15M049280
  • GC15M026112

Summaries for SECISBP2L Gene

GeneCards Summary for SECISBP2L Gene

SECISBP2L (SECIS Binding Protein 2-Like) is a Protein Coding gene. An important paralog of this gene is SECISBP2.

UniProtKB/Swiss-Prot for SECISBP2L Gene

  • Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SECISBP2L Gene

Genomics for SECISBP2L Gene

Regulatory Elements for SECISBP2L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SECISBP2L Gene

Start:
48,988,476 bp from pter
End:
49,046,563 bp from pter
Size:
58,088 bases
Orientation:
Minus strand

Genomic View for SECISBP2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SECISBP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SECISBP2L Gene

Proteins for SECISBP2L Gene

  • Protein details for SECISBP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93073-SBP2L_HUMAN
    Recommended name:
    Selenocysteine insertion sequence-binding protein 2-like
    Protein Accession:
    Q93073
    Secondary Accessions:
    • Q8N767

    Protein attributes for SECISBP2L Gene

    Size:
    1101 amino acids
    Molecular mass:
    121776 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13386.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SECISBP2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SECISBP2L Gene

Proteomics data for SECISBP2L Gene at MOPED

Post-translational modifications for SECISBP2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SECISBP2L Gene

No data available for DME Specific Peptides for SECISBP2L Gene

Domains for SECISBP2L Gene

Protein Domains for SECISBP2L Gene

Suggested Antigen Peptide Sequences for SECISBP2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SECISBP2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SECISBP2L Gene

Function for SECISBP2L Gene

Molecular function for SECISBP2L Gene

UniProtKB/Swiss-Prot Function: Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro

Gene Ontology (GO) - Molecular Function for SECISBP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SECISBP2L: view

Animal Model Products

CRISPR Products

miRNA for SECISBP2L Gene

miRTarBase miRNAs that target SECISBP2L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SECISBP2L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SECISBP2L Gene

Localization for SECISBP2L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SECISBP2L Gene COMPARTMENTS Subcellular localization image for SECISBP2L gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SECISBP2L Gene

Pathways for SECISBP2L Gene

SuperPathways for SECISBP2L Gene

No Data Available

Interacting Proteins for SECISBP2L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000453854%0d%0a9606.ENSP00000240343%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000453854 Q93073-SBP2L_HUMAN for SECISBP2L Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for SECISBP2L Gene

None

No data available for Pathways by source for SECISBP2L Gene

Transcripts for SECISBP2L Gene

Unigene Clusters for SECISBP2L Gene

SECIS binding protein 2-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SECISBP2L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SECISBP2L Gene

No ASD Table

Relevant External Links for SECISBP2L Gene

GeneLoc Exon Structure for
SECISBP2L
ECgene alternative splicing isoforms for
SECISBP2L

Expression for SECISBP2L Gene

mRNA expression in normal human tissues for SECISBP2L Gene

mRNA differential expression in normal tissues according to GTEx for SECISBP2L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SECISBP2L Gene

SOURCE GeneReport for Unigene cluster for SECISBP2L Gene Hs.9997

genes like me logo Genes that share expressions with SECISBP2L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SECISBP2L Gene

Orthologs for SECISBP2L Gene

This gene was present in the common ancestor of animals.

Orthologs for SECISBP2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SECISBP2L 35
  • 99.76 (n)
  • 99.82 (a)
SECISBP2L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SECISBP2L 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SECISBP2L 35
  • 93.77 (n)
  • 94.9 (a)
SECISBP2L 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Secisbp2l 35
  • 84.97 (n)
  • 88.15 (a)
Secisbp2l 16
Secisbp2l 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SECISBP2L 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SECISBP2L 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Secisbp2l 35
  • 85.45 (n)
  • 88.81 (a)
chicken
(Gallus gallus)
Aves SECISBP2L 35
  • 78.75 (n)
  • 82.14 (a)
SECISBP2L 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SECISBP2L 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13483 35
tropical clawed frog
(Silurana tropicalis)
Amphibia secisbp2l 35
  • 70.65 (n)
  • 71.46 (a)
zebrafish
(Danio rerio)
Actinopterygii secisbp2l 35
  • 61.21 (n)
  • 61.65 (a)
SECISBP2L 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sbp2 36
  • 30 (a)
OneToMany
Species with no ortholog for SECISBP2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SECISBP2L Gene

ENSEMBL:
Gene Tree for SECISBP2L (if available)
TreeFam:
Gene Tree for SECISBP2L (if available)

Paralogs for SECISBP2L Gene

Paralogs for SECISBP2L Gene

Selected SIMAP similar genes for SECISBP2L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SECISBP2L: view

Variants for SECISBP2L Gene

Sequence variations from dbSNP and Humsavar for SECISBP2L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs877007 -- 49,036,706(-) AGGCT(C/G)TTAAT intron-variant
rs877008 -- 49,036,650(-) TTTCA(A/G)TTGAA intron-variant
rs1054307 -- 48,989,427(-) GAGGT(G/T)GTTTT utr-variant-3-prime
rs1989332 -- 49,031,106(+) tgcag(G/T)gatgt intron-variant
rs2305195 -- 49,017,953(+) TTTGA(A/G)AAAGT intron-variant

Relevant External Links for SECISBP2L Gene

HapMap Linkage Disequilibrium report
SECISBP2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SECISBP2L Gene

Disorders for SECISBP2L Gene

No disorders were found for SECISBP2L Gene.

No data available for UniProtKB/Swiss-Prot for SECISBP2L Gene

Publications for SECISBP2L Gene

  1. Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression. (PMID: 22530054) Donovan J. … Copeland P.R. (PLoS ONE 2012) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  4. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PMID: 12766061) Tomarev S.I. … Malyukova I. (Invest. Ophthalmol. Vis. Sci. 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SECISBP2L Gene

Sources for SECISBP2L Gene

Back to Top

Content