SECISBP2L Gene
protein-coding GIFtS: 41
GCID: GC15M049280
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SECIS binding protein 2-like
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Aliases
for SECISBP2L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SECIS Binding Protein 2-Like1 2 | | KIAA02561 3 | | SECIS-Binding Protein 2-Like2 3 | | SBP2L2 | | SLAN2 | | Selenocysteine Insertion Sequence-Binding Protein 2-Like2 |
Export aliases for SECISBP2L gene to outside databasesPrevious GC identifers: GC15M047069 GC15M026112 |
Summaries
for SECISBP2L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SECISBP2L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SECISBP2L gene promoter:
ATF-2 Bach2 MEF-2 Nkx2-5 GATA-1 MEF-2A SRY POU2F1 POU2F1a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SECISBP2L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SECISBP2L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21.1 Ensembl cytogenetic band: 15q21.1 HGNC cytogenetic band: 15q21.1SECISBP2L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M049280: view genomic region
(about GC identifiers)
Start:
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49,280,673 bp from pter |
End:
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49,338,760 bp from pter |
Size:
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58,088 bases |
Orientation:
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minus strand |
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Proteins
for SECISBP2L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SBP2L_HUMAN, Q93073 (See
protein sequence)Recommended Name: Selenocysteine insertion sequence-binding protein 2-like Size: 1101 amino acids; 121776 Da
Sequence caution: Sequence=BAA13386.3; Type=Erroneous initiation;
Secondary accessions: Q8N767Alternative splicing: 2 isoforms: Q93073-1 Q93073-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SECISBP2L: NX_Q93073
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q93073
SECISBP2L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001180418.1 NP_055516.2
ENSEMBL proteins: ENSP00000454144 ENSP00000453854 ENSP00000261847 ENSP00000370314 ENSP00000452987
Human Recombinant Protein Products for SECISBP2L:
SECISBP2L Antibody Products:
Assay Products for SECISBP2L: |
Protein
Domains /
Families
for SECISBP2L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SECISBP2L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q93073ProtoNet protein and cluster: Q93073 |
Function
for SECISBP2L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SECISBP2L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SECISBP2L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SECISBP2L (NM_014701) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SECISBP2L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECISBP2L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECISBP2L |
|
Pathways & Interactions
for SECISBP2L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SECISBP2L
1 Interacting protein for SECISBP2L (Q930733) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SECISBP2L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SECISBP2L
Search CenterWatch for drugs/clinical trials and news about SECISBP2L / SBP2L
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Transcripts
for SECISBP2L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SECISBP2L gene (2 alternative transcripts): NM_001193489.1 NM_014701.3 Unigene Cluster for SECISBP2L: SECIS binding protein 2-like Hs.9997 [show with all ESTs]Unigene Representative Sequence: NM_00119348911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000561428 ENST00000559471(uc001zxe.2 uc001zxd.2 uc010bep.2 uc010beq.2)
ENST00000261847 ENST00000380927 ENST00000559122 ENST00000559198 ENST00000561203
ENST00000557940 ENST00000559424 ENST00000558461 ENST00000557923
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SECISBP2L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SECISBP2L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SECISBP2L (NM_014701) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SECISBP2L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECISBP2L |
Additional cDNA sequence: AK307480.1 AK308183.1 BC008635.1 BC033001.2 D87445.3 12 DOTS entries: DT.97767328 DT.449056 DT.92416989 DT.75173763 DT.91983409 DT.121032676 DT.121032696 DT.91999451 DT.95368570 DT.97763365 DT.40294887 DT.97805126 24/194 AceView cDNA sequences (see all 194): AI274076 H04759 BF087687 AA832059 AA341845 AW264521 AI828838 BM315041 AA723013 AA635663 AA281825 AI399797 AA778852 BE048795 CD678675 D87445 H88186 AA348571 BC008635 AA993159 BU676262 AA341844 AI948467 CA950658
GeneLoc Exon Structure
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Expression
for SECISBP2L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SECISBP2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTTCTGT
About this image
See SECISBP2L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SECISBP2L
SOURCE GeneReport for Unigene cluster: Hs.9997
SABiosciences Custom PCR Arrays for SECISBP2L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SECISBP2L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SECISBP2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SECISBP2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SECISBP2L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECISBP2L |
Orthologs
for SECISBP2L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SECISBP2L gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for SECISBP2L (if available)
TreeFam Gene Tree for SECISBP2L (if available) |
Paralogs
for SECISBP2L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SECISBP2L gene
- SECISBP22
2 SIMAP similar genes for SECISBP2L using alignment to 4 protein entries: SBP2L_HUMAN (see all proteins):SBP2 SECISBP2
SECISBP2L for paralogs About GeneDecksing
|
Genomic Variants
for SECISBP2L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SECISBP2L (49280673 - 49338760 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SECISBP2L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SECISBP2L |
|
Disorders
/ Diseases
for SECISBP2L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SECISBP2L for disorders About GeneDecksing
1  disease for SECISBP2L: About MalaCardslung cancer
Export disorders for SECISBP2L gene to outside databases
|
Publications
for SECISBP2L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SECISBP2L gene integrated from 9 sources:
(articles sorted by number of sources associating them with SECISBP2L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
- Selenocysteine insertion sequence binding protein 2L i s implicated as a novel post-transcriptional regulator of selenoprotein expressi on. (PubMed id 22530054)1 Donovan J. and Copeland P.R. (2012)
- The novel protein suppressed in lung cancer down-regu lated in lung cancer tissues retards cell proliferation and inhibits the oncoki nase Aurora-A. (PubMed id 21566536)1 Yu C.T....Hsu S.L. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PubMed id 12766061)1 Tomarev S.I....Malyukova I. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SECISBP2L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SECISBP2L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SECISBP2L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SECISBP2L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SECISBP2L | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SECISBP2L gene:
Search GeneIP for patents involving SECISBP2L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SECISBP2L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SECISBP2L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SECISBP2L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SECISBP2L | | | OriGene Protein Over-expression Lysate for SECISBP2L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SECISBP2L | | OriGene 3'-UTR Clone for SECISBP2L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SECISBP2L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SECISBP2L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SECISBP2L | | OriGene Custom Protein Services for SECISBP2L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SECISBP2L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SECISBP2L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SECISBP2L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SECISBP2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SECISBP2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SECISBP2L |
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 | | | SECISBP2L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECISBP2L |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECISBP2L |
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