Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SECISBP2 Gene

protein-coding   GIFtS: 54
GCID: GC09P091933

SECIS Binding Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SECIS Binding Protein 21 2
SBP22 3 5
Selenocysteine Insertion Sequence-Binding Protein 22
SECIS-Binding Protein 23

External Ids:    HGNC: 309721   Entrez Gene: 790482   Ensembl: ENSG000001877427   OMIM: 6076935   UniProtKB: Q96T213   

Export aliases for SECISBP2 gene to outside databases

Previous GC identifers: GC09P087423 GC09P089162 GC09P091123 GC09P061766


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SECISBP2 Gene:
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec
insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein.
With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record
encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated
with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal
thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Sep
2013)

GeneCards Summary for SECISBP2 Gene: 
SECISBP2 (SECIS binding protein 2) is a protein-coding gene. Diseases associated with SECISBP2 include thyroid hormone metabolism, abnormal, and sepn1-related myopathy. GO annotations related to this gene include mRNA 3'-UTR binding. An important paralog of this gene is SECISBP2L.

UniProtKB/Swiss-Prot: SEBP2_HUMAN, Q96T21
Function: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by
SELB

Gene Wiki entry for SECISBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SECISBP2 gene promoter:
         Pbx1a   FOXD3   AP-4   YY1   CREB   Max   deltaCREB   FOXO1a   FOXO1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSECISBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SECISBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SECISBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.2   Ensembl cytogenetic band:  9q22.2   HGNC cytogenetic band: 9q22

SECISBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SECISBP2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P091933:  view genomic region     (about GC identifiers)

Start:
91,933,412 bp from pter      End:
91,974,561 bp from pter
Size:
41,150 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEBP2_HUMAN, Q96T21 (See protein sequence)
Recommended Name: Selenocysteine insertion sequence-binding protein 2  
Size: 854 amino acids; 95462 Da
Subunit: Interacts with SELB (By similarity)
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5HYY1 Q8IYC0 Q9H0A1
Alternative splicing: 2 isoforms:  Q96T21-1   Q96T21-2   

Explore the universe of human proteins at neXtProt for SECISBP2: NX_Q96T21

Explore proteomics data for SECISBP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96T21

  • SECISBP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SECISBP2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269617.1  NP_001269618.1  NP_001269619.1  NP_076982.3  

    ENSEMBL proteins: 
     ENSP00000364965   ENSP00000364959   ENSP00000414288   ENSP00000411573   ENSP00000436650  

    Human Recombinant Protein Products for SECISBP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SECISBP2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SECISBP2
    GenScript Custom Purified and Recombinant Proteins Services for SECISBP2
    Novus Biologicals SECISBP2 Protein
    Novus Biologicals SECISBP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--

    SECISBP2 for ontologies           About GeneDecksing



    SECISBP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SECISBP2
    OriGene Custom Antibody Services for SECISBP2
    GenScript Custom Superior Antibodies Services for SECISBP2
    Novus Biologicals SECISBP2 Antibodies
    Abcam antibodies for SECISBP2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SECISBP2
    LSBio Antibodies in human, mouse, rat for SECISBP2 

    Assay Products for SECISBP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SECISBP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SECISBP2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45

    Graphical View of Domain Structure for InterPro Entry Q96T21

    ProtoNet protein and cluster: Q96T21

    1 Blocks protein domain: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45


    SECISBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEBP2_HUMAN, Q96T21
    Function: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by
    SELB

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003730mRNA 3'-UTR binding IDA16962588
         
    SECISBP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Secisbp2):
     other 

    SECISBP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SECISBP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SECISBP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SECISBP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SECISBP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SECISBP2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SECISBP2 (see all 12):
    hsa-miR-485-5p hsa-miR-181c hsa-miR-1237 hsa-miR-181a hsa-miR-181d hsa-miR-520a-5p hsa-miR-525-5p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSECISBP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SECISBP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SECISBP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SECISBP2
    Sirion Biotech Customized adenovirus for overexpression of SECISBP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SECISBP2 (see all 8)
    OriGene ORF clones in mouse, rat for SECISBP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SECISBP2 (NM_014701)
    Sino Biological Human cDNA Clone for SECISBP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SECISBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECISBP2
    Sirion Biotech Customized lentivirus for stable overexpression of SECISBP2 
                         Customized lentivirus expression plasmids for stable overexpression of SECISBP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SECISBP2
    Search LifeMap BioReagents cell lines for SECISBP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECISBP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SECISBP2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for SECISBP2 (Q96T212, 3 ENSP000003649654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62087 I2D: score=3 
    ATXN7L3Q14CW93, ENSP000003972594I2D: score=2 STRING: ENSP00000397259
    CCDC109BQ9NWR83I2D: score=1 
    RHOXF2Q9BQY43I2D: score=1 
    --Q9WMX22MINT-7048321
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    SECISBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SECISBP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SECISBP2 (SEBP2)

    2 Novoseek inferred chemical compound relationships for SECISBP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenocysteine 94.8 56 16782878 (4), 11118223 (2), 11680849 (2), 19602558 (2) (see all 19)
    selenophosphate 78.3 2 15096516 (1)

    Search CenterWatch for drugs/clinical trials and news about SECISBP2 / SEBP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SECISBP2 gene (4 alternative transcripts): 
    NM_001282688.1  NM_001282689.1  NM_001282690.1  NM_024077.4  

    Unigene Clusters for SECISBP2:

    SECIS binding protein 2
    Hs.59804  [show with all ESTs], Hs.667515  [show with all ESTs]
    Unigene Representative Sequences: NM_024077, AK127655
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375807(uc010mqn.1 uc004aqi.1 uc004aqj.1 uc004aqk.1 uc011ltk.1 uc010mqo.1 uc011ltl.1)
    ENST00000339901 ENST00000470305 ENST00000425851 ENST00000440898 ENST00000477484
    ENST00000498819 ENST00000496597 ENST00000534113
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SECISBP2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SECISBP2 (see all 12):
    hsa-miR-485-5p hsa-miR-181c hsa-miR-1237 hsa-miR-181a hsa-miR-181d hsa-miR-520a-5p hsa-miR-525-5p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSECISBP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SECISBP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SECISBP2
    Clone
    Products:
         
    OriGene clones in human, mouse for SECISBP2 (see all 8)
    OriGene ORF clones in mouse, rat for SECISBP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SECISBP2 (NM_014701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SECISBP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECISBP2
    Sirion Biotech Customized lentivirus for stable overexpression of SECISBP2 
                         Customized lentivirus expression plasmids for stable overexpression of SECISBP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SECISBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for SECISBP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SECISBP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SECISBP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SECISBP2

    Additional mRNA sequence: AK127655.1 

    17 DOTS entries:

    DT.87016947  DT.75163139  DT.87046362  DT.95271181  DT.92442903  DT.40220991  DT.100793688  DT.210095 
    DT.306235  DT.100793686  DT.101984236  DT.121168802  DT.95316851  DT.121168738  DT.92442904  DT.92442906 
    DT.95070877 

    24/288 AceView cDNA sequences (see all 288):

    BQ100973 AA378033 CB306790 BE857725 BQ049808 BE674458 BM978794 AI933679 
    AX746532 BQ938269 BU679370 AL136881 CD171759 BC001189 AW470022 AI285237 
    CK823041 BM557450 BM825058 AA704707 AA704491 BG572344 AI963841 AK090608 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SECISBP2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                                                                            
    SP2:                    -                       -                                   -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                -                                                                           
    SP5:                                                                                                              -                                             

    ExUns: 18a · 18b ^ 19 ^ 20
    SP1:  -                     
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SECISBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SECISBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGCCATT
    SECISBP2 Expression
    About this image


    See SECISBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SECISBP2

    SOURCE GeneReport for Unigene clusters: Hs.59804 Hs.667515

    UniProtKB/Swiss-Prot: SEBP2_HUMAN, Q96T21
    Tissue specificity: Expressed at high levels in testis

        SABiosciences Custom PCR Arrays for SECISBP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SECISBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for SECISBP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SECISBP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SECISBP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SECISBP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECISBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SECISBP2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Secisbp21 , 5 SECIS binding protein 21, 5 77.71(n)1
    72.74(a)1
      13 (26.12 cM)5
    754201  NM_029279.11  NP_083555.11 
     516516975 
    chicken
    (Gallus gallus)
    Aves SECISBP21 SECIS binding protein 2 57.61(n)
    49.11(a)
      426815  XM_424425.3  XP_424425.3 
    lizard
    (Anolis carolinensis)
    Reptilia SECISBP26
    SECIS binding protein 2
    40(a)
    1 ↔ 1
    2(36831966-36873997)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.187612 Transcribed sequence with weak similarity to protein more 82.22(n)    BX769523.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SECISBP26
    SECIS binding protein 2
    43(a)
    1 ↔ 1
    5(69235753-69259409)
    fruit fly
    (Drosophila melanogaster)
    Insecta Sbp21 SECIS-binding protein 2 41.28(n)
    29.14(a)
      38934  NM_139947.2  NP_648204.1 


    ENSEMBL Gene Tree for SECISBP2 (if available)
    TreeFam Gene Tree for SECISBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SECISBP2 gene
    SECISBP2L2  
    3 SIMAP similar genes for SECISBP2 using alignment to 5 protein entries:     SEBP2_HUMAN (see all proteins):
    DKFZp686C09169    SBP2    SECISBP2L

    SECISBP2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SECISBP2
    PGOHUM00000234955 PGOHUM00000233069


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/932 SNPs in SECISBP2 are shown (see all 932)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0252824
    Abnormal thyroid hormone metabolism (ATHYHM)4--see VAR_0252822 R Q mis40--------
    rs1880514421,2
    --91809711(+) AATACC/TTGAGA 1 -- us2k10--------
    rs148671,2
    C,F,A,H--91809729(+) AAATCT/CTTCAT 1 -- us2k1100Minor allele frequency- C:0.22MN NS EA NA PA EU CA WA 6122
    rs32116931,2
    C,F--91809811(+) GTAAGA/TTGTTT 1 -- us2k11Minor allele frequency- T:0.01NS 170
    rs32116941,2
    C,F--91809960(+) GACTAT/CTGAAA 1 -- us2k12Minor allele frequency- C:0.02NS CSA 176
    rs32116951,2
    F--91809970(+) ATTTGTGACTATT
    GAAATTG
    /-
    ATTTC
    1 -- us2k11Minor allele frequency- -:0.01NS 178
    rs1385559671,2
    --91809998(+) GTTATA/TGTTTT 1 -- us2k10--------
    rs1812513681,2
    --91809999(+) TTATAC/GTTTTA 1 -- us2k10--------
    rs32116961,2
    C,F--91810035(+) AAGATG/AATGTT 1 -- us2k11Minor allele frequency- A:0.01NS 176
    rs763470331,2
    C,F--91810042(+) TGTTAA/GATGAG 1 -- us2k12Minor allele frequency- G:0.13NA 122

    HapMap Linkage Disequilibrium report for SECISBP2 (91933412 - 91974561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SECISBP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270568CNV Insertion20981092
    nsv831651CNV Gain17160897
    esv29434CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): SECISBP2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SECISBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SECISBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607693   
    OMIM disorders: 609698  
    UniProtKB/Swiss-Prot: SEBP2_HUMAN, Q96T21
  • Abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]: A disorder associated with a reduction in type
    II iodothyronine deiodinase activity. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 5 diseases for SECISBP2:    About MalaCards
    thyroid hormone metabolism, abnormal    sepn1-related myopathy    thyroiditis    myopathy
    colorectal cancer


    SECISBP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SECISBP2
    Human Genome Epidemiology (HuGE) Navigator: SECISBP2 (3 documents)

    Export disorders for SECISBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SECISBP2 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with SECISBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PubMed id 20378690)1, 4 MAcplan C....Hesketh J.E. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. (PubMed id 16228000)1, 2 Dumitrescu A.M....Refetoff S. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2. (PubMed id 12095701)1, 2 Lescure A.... Krol A. (2002)
    8. The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. (PubMed id 16782878)1, 9 Papp L.V....Khanna K.K. (2006)
    9. Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2. (PubMed id 19106619)1, 9 Bubenik J.L....Driscoll D.M. (2009)
    10. Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations. (PubMed id 19265499)1, 9 Schomburg L....Refetoff S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79048 HGNC: 30972 AceView: SECISBP2 Ensembl:ENSG00000187742 euGenes: HUgn79048
    ECgene: SECISBP2 H-InvDB: SECISBP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SECISBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SECISBP2 gene:
    Search GeneIP for patents involving SECISBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SECISBP2   OriGene RNAi products in human, mouse, rat for SECISBP2  
     OriGene qPCR primer pairs and template standards for SECISBP2   OriGene Protein Over-expression Lysate for SECISBP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SECISBP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SECISBP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SECISBP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SECISBP2   OriGene Custom Protein Services for SECISBP2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SECISBP2
     QIAGEN SeqTarget long-range PCR primers for resequencing SECISBP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SECISBP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SECISBP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SECISBP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SECISBP2
     GenScript Custom Purified and Recombinant Proteins Services for SECISBP2 GenScript cDNA clones with any tag delivered in your preferred vector for SECISBP2
     GenScript Custom Assay Services for SECISBP2 GenScript Custom Superior Antibodies Services for SECISBP2
     GenScript Custom overexpressing Cell Line Services for SECISBP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SECISBP2 promoter
     Search Chromatin IP Primers for SECISBP2
     RT2 qPCR Primer Assay in human, mouse, rat SECISBP2
     GNC Network for SECISBP2
     SABiosciences Custom PCR Arrays for SECISBP2
     Search Tocris compounds for SECISBP2 (SEBP2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SECISBP2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SECISBP2 antibodies
     SECISBP2 proteins
     SECISBP2 lysates
     Antibodies for SECISBP2
     See all of Abcam's Antibodies, Kits and Proteins for SECISBP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SECISBP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SECISBP2
     SwitchGear 3'UTR luciferase reporter plasmids for SECISBP2
     SwitchGear Promoter luciferase reporter plasmids for SECISBP2
     ThermoFisher Antibodies for SECISBP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SECISBP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SECISBP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SECISBP2
    Customized:
     lentivirus for stable overexpression of SECISBP2
     lentivirus expression plasmids for stable overexpression of SECISBP2
     adenovirus for overexpression of SECISBP2
     LSBio Antibodies in human, mouse, rat for SECISBP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SECISBP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4