Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SECISBP2 Gene

Aliases for SECISBP2 Gene

  • SECIS Binding Protein 2 2 3
  • SBP2 3 4 6
  • Selenocysteine Insertion Sequence-Binding Protein 2 3
  • SECIS-Binding Protein 2 4

External Ids for SECISBP2 Gene

Previous GeneCards Identifiers for SECISBP2 Gene

  • GC09P087423
  • GC09P089162
  • GC09P091123
  • GC09P091933
  • GC09P061766

Summaries for SECISBP2 Gene

Entrez Gene Summary for SECISBP2 Gene

  • The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for SECISBP2 Gene

SECISBP2 (SECIS Binding Protein 2) is a Protein Coding gene. Diseases associated with SECISBP2 include thyroid hormone metabolism, abnormal and short stature-delayed bone age due to thyroid hormone metabolism deficiency. GO annotations related to this gene include mRNA 3-UTR binding. An important paralog of this gene is SECISBP2L.

UniProtKB/Swiss-Prot for SECISBP2 Gene

  • Binds to the SECIS element in the 3-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB

Gene Wiki entry for SECISBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SECISBP2 Gene

Genomics for SECISBP2 Gene

Regulatory Elements for SECISBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SECISBP2 Gene

Start:
89,318,473 bp from pter
End:
89,359,663 bp from pter
Size:
41,191 bases
Orientation:
Plus strand

Genomic View for SECISBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SECISBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SECISBP2 Gene

Proteins for SECISBP2 Gene

  • Protein details for SECISBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T21-SEBP2_HUMAN
    Recommended name:
    Selenocysteine insertion sequence-binding protein 2
    Protein Accession:
    Q96T21
    Secondary Accessions:
    • F8W892
    • Q5HYY1
    • Q7L1Z0
    • Q8IYC0
    • Q9H0A1

    Protein attributes for SECISBP2 Gene

    Size:
    854 amino acids
    Molecular mass:
    95462 Da
    Quaternary structure:
    • Interacts with SELB.

    Alternative splice isoforms for SECISBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SECISBP2 Gene

Proteomics data for SECISBP2 Gene at MOPED

Post-translational modifications for SECISBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SECISBP2 Gene

Antibody Products

No data available for DME Specific Peptides for SECISBP2 Gene

Domains for SECISBP2 Gene

Protein Domains for SECISBP2 Gene

Suggested Antigen Peptide Sequences for SECISBP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SECISBP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SECISBP2 Gene

Function for SECISBP2 Gene

Molecular function for SECISBP2 Gene

UniProtKB/Swiss-Prot Function: Binds to the SECIS element in the 3-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB

Gene Ontology (GO) - Molecular Function for SECISBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3-UTR binding IDA 16962588
GO:0005515 protein binding IPI 25416956
GO:0035368 selenocysteine insertion sequence binding IEA --
GO:0043021 ribonucleoprotein complex binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SECISBP2: view

Phenotypes for SECISBP2 Gene

MGI mutant phenotypes for SECISBP2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SECISBP2: view

Animal Model Products

CRISPR Products

miRNA for SECISBP2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SECISBP2 Gene

Localization for SECISBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SECISBP2 Gene

Isoform 1: Nucleus.
Isoform 2: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SECISBP2 Gene COMPARTMENTS Subcellular localization image for SECISBP2 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SECISBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with SECISBP2: view

Pathways for SECISBP2 Gene

SuperPathways for SECISBP2 Gene

No Data Available

Interacting Proteins for SECISBP2 Gene

Gene Ontology (GO) - Biological Process for SECISBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation IEA --
GO:0006412 translation --
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA --
genes like me logo Genes that share ontologies with SECISBP2: view

No data available for Pathways by source for SECISBP2 Gene

Compounds for SECISBP2 Gene

(2) Novoseek inferred chemical compound relationships for SECISBP2 Gene

Compound -log(P) Hits PubMed IDs
selenocysteine 94.8 26
selenophosphate 78.3 1
genes like me logo Genes that share compounds with SECISBP2: view

Transcripts for SECISBP2 Gene

Unigene Clusters for SECISBP2 Gene

SECIS binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SECISBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SECISBP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1:
SP2: - - -
SP3:
SP4: -
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11: - - - - -
SP12: - - - -

ExUns: 18a · 18b ^ 19 ^ 20
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SECISBP2 Gene

GeneLoc Exon Structure for
SECISBP2
ECgene alternative splicing isoforms for
SECISBP2

Expression for SECISBP2 Gene

mRNA expression in normal human tissues for SECISBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SECISBP2 Gene

SOURCE GeneReport for Unigene cluster for SECISBP2 Gene Hs.59804

mRNA Expression by UniProt/SwissProt for SECISBP2 Gene

Q96T21-SEBP2_HUMAN
Tissue specificity: Expressed at high levels in testis.
genes like me logo Genes that share expressions with SECISBP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SECISBP2 Gene

Orthologs for SECISBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SECISBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SECISBP2 35
  • 99.53 (n)
  • 99.18 (a)
SECISBP2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SECISBP2 35
  • 83.83 (n)
  • 78.73 (a)
SECISBP2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SECISBP2 35
  • 81.3 (n)
  • 78.22 (a)
SECISBP2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Secisbp2 35
  • 77.92 (n)
  • 72.94 (a)
Secisbp2 16
Secisbp2 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SECISBP2 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Secisbp2 35
  • 78.98 (n)
  • 73.28 (a)
chicken
(Gallus gallus)
Aves SECISBP2 35
  • 58 (n)
  • 49.62 (a)
SECISBP2 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SECISBP2 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia secisbp2 35
  • 60.73 (n)
  • 57.46 (a)
Str.18761 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4041 35
zebrafish
(Danio rerio)
Actinopterygii LOC101883890 35
  • 57.9 (n)
  • 53.74 (a)
secisbp2 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sbp2 36
  • 27 (a)
OneToMany
Species with no ortholog for SECISBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SECISBP2 Gene

ENSEMBL:
Gene Tree for SECISBP2 (if available)
TreeFam:
Gene Tree for SECISBP2 (if available)

Paralogs for SECISBP2 Gene

Paralogs for SECISBP2 Gene

Selected SIMAP similar genes for SECISBP2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SECISBP2 Gene

genes like me logo Genes that share paralogs with SECISBP2: view

Variants for SECISBP2 Gene

Sequence variations from dbSNP and Humsavar for SECISBP2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3087798 -- 89,334,621(-) CAATG(G/T)TCTTT missense, reference, intron-variant, nc-transcript-variant
rs3211701 -- 89,317,220(+) ATCAG(A/G)TCCAT upstream-variant-2KB
rs3211702 -- 89,317,308(+) GCCAC(A/T)ACCAT upstream-variant-2KB
rs3211703 -- 89,317,394(+) AGTGC(C/T)GAAAG upstream-variant-2KB
rs3211704 -- 89,317,602(+) GAAAC(C/G)TACAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SECISBP2 Gene

Variant ID Type Subtype PubMed ID
nsv831651 CNV Gain 17160897
esv270568 CNV Insertion 20981092
esv29434 CNV Gain+Loss 19812545

Relevant External Links for SECISBP2 Gene

HapMap Linkage Disequilibrium report
SECISBP2
Human Gene Mutation Database (HGMD)
SECISBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SECISBP2 Gene

Disorders for SECISBP2 Gene

(1) OMIM Diseases for SECISBP2 Gene (607693)

UniProtKB/Swiss-Prot

SEBP2_HUMAN
  • Abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]: A disorder associated with a reduction in type II iodothyronine deiodinase activity. {ECO:0000269 PubMed:16228000}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SECISBP2

Genetic Association Database (GAD)
SECISBP2
Human Genome Epidemiology (HuGE) Navigator
SECISBP2
genes like me logo Genes that share disorders with SECISBP2: view

Publications for SECISBP2 Gene

  1. Functional characterization of alternatively spliced human SECISBP2 transcript variants. (PMID: 19004874) Papp L.V. … Khanna K.K. (Nucleic Acids Res. 2008) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2. (PMID: 12095701) Lescure A. … Krol A. (Gene 2002) 3 4
  4. Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations. (PMID: 19265499) Schomburg L. … Refetoff S. (Thyroid 2009) 3 23
  5. SECIS-binding protein 2, a key player in selenoprotein synthesis, is an intrinsically disordered protein. (PMID: 19467292) OliAcric V. … Dumas P. (Biochimie 2009) 3 23

Products for SECISBP2 Gene

Sources for SECISBP2 Gene

Back to Top

Content