Aliases for SECISBP2 Gene
External Ids for SECISBP2 Gene
Previous GeneCards Identifiers for SECISBP2 Gene
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for SECISBP2 Gene
SECISBP2 (SECIS Binding Protein 2) is a Protein Coding gene. Diseases associated with SECISBP2 include thyroid hormone metabolism, abnormal and short stature-delayed bone age due to thyroid hormone metabolism deficiency. GO annotations related to this gene include mRNA 3-UTR binding. An important paralog of this gene is SECISBP2L.
UniProtKB/Swiss-Prot for SECISBP2 Gene
Binds to the SECIS element in the 3-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB