Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEC63 Gene

Aliases for SEC63 Gene

  • SEC63 Homolog, Protein Translocation Regulator 2 3 5
  • SEC63L 3 4
  • SEC63 Protein Translocation Regulator 3
  • Translocation Protein SEC63 Homolog 3
  • SEC63 Homolog (S. Cerevisiae) 2
  • SEC63-Like (S. Cerevisiae) 2
  • SEC63-Like Protein 3
  • SEC63 Homolog 3
  • SEC63-Like 3
  • DNAJC23 3
  • PRO2507 3
  • ERdj2 3
  • PCLD2 3

External Ids for SEC63 Gene

Previous GeneCards Identifiers for SEC63 Gene

  • GC06M108192
  • GC06M108237
  • GC06M108298
  • GC06M105758
  • GC06M108188

Summaries for SEC63 Gene

Entrez Gene Summary for SEC63 Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC63 Gene

SEC63 (SEC63 Homolog, Protein Translocation Regulator) is a Protein Coding gene. Diseases associated with SEC63 include Polycystic Liver Disease. Among its related pathways are Protein processing in endoplasmic reticulum and Metabolism of proteins. GO annotations related to this gene include poly(A) RNA binding and receptor activity.

UniProtKB/Swiss-Prot for SEC63 Gene

  • Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

Gene Wiki entry for SEC63 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC63 Gene

Genomics for SEC63 Gene

Regulatory Elements for SEC63 Gene

Enhancers for SEC63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F107847 1.6 FANTOM5 Ensembl ENCODE 16.4 +109.9 109878 1.2 SIN3A ARID4B DMAP1 ZNF48 ZNF2 GLIS2 ELK1 ZNF143 ZNF263 ZNF202 SEC63 BEND3 SCML4 ENSG00000280135
GH06F108001 1.2 Ensembl ENCODE 16.7 -44.5 -44494 3.1 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF143 NFYC PPARG KAT8 SEC63 RPL3P7 MTHFD2P3
GH06F108117 1.7 Ensembl 9.5 -159.9 -159856 1.5 L3MBTL2 SUZ12 RNF2 HLF CBX2 JUNB CEBPB CBX8 ZBTB48 CTBP2 NR2E1 OSTM1 SEC63 OSTM1-AS1 ENSG00000238490
GH06F108712 1.4 FANTOM5 Ensembl ENCODE 10.9 -756.0 -756023 3.4 PKNOX1 ARID4B SIN3A FEZF1 RAD21 ZNF121 EGR2 OVOL3 CEBPB ZEB2 ENSG00000271730 SEC63 PIR33619 LINC00222
GH06F107972 1.2 ENCODE 12.4 -14.8 -14752 2.0 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000230248 LOC100506224 ENSG00000227072 SEC63 PDSS2 RNU6-437P RPL23AP50 ENSG00000224987
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC63 on UCSC Golden Path with GeneCards custom track

Promoters for SEC63 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001498393 878 3201 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 FOS

Genomic Location for SEC63 Gene

Chromosome:
6
Start:
107,867,756 bp from pter
End:
107,958,278 bp from pter
Size:
90,523 bases
Orientation:
Minus strand

Genomic View for SEC63 Gene

Genes around SEC63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC63 Gene

Proteins for SEC63 Gene

  • Protein details for SEC63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGP8-SEC63_HUMAN
    Recommended name:
    Translocation protein SEC63 homolog
    Protein Accession:
    Q9UGP8
    Secondary Accessions:
    • O95380
    • Q5THN4
    • Q86VS9
    • Q8IWL0
    • Q9NTE0

    Protein attributes for SEC63 Gene

    Size:
    760 amino acids
    Molecular mass:
    87997 Da
    Quaternary structure:
    • Part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63.
    SequenceCaution:
    • Sequence=AAH23598.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for SEC63 Gene

Post-translational modifications for SEC63 Gene

  • Ubiquitination at Lys 135, Lys 147, Lys 300, Lys 381, Lys 407, Lys 633, Lys 688, and Lys 710
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC63 Gene

Antibody Products

  • Abcam antibodies for SEC63
  • Santa Cruz Biotechnology (SCBT) Antibodies for SEC63

No data available for DME Specific Peptides for SEC63 Gene

Domains & Families for SEC63 Gene

Gene Families for SEC63 Gene

Protein Domains for SEC63 Gene

Suggested Antigen Peptide Sequences for SEC63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGP8

UniProtKB/Swiss-Prot:

SEC63_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
  • Contains 2 SEC63 domains.
genes like me logo Genes that share domains with SEC63: view

Function for SEC63 Gene

Molecular function for SEC63 Gene

GENATLAS Biochemistry:
S cerevisiae SEC63P homolog rough,endoplamic reticulum integral membrane protein,component of the transmembrane complex that mediates posttranslational translocation of nescent peptides across the ER
UniProtKB/Swiss-Prot Function:
Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

Gene Ontology (GO) - Molecular Function for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10799540
GO:0005515 protein binding IPI 21251912
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SEC63: view
genes like me logo Genes that share phenotypes with SEC63: view

Human Phenotype Ontology for SEC63 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SEC63 Gene

MGI Knock Outs for SEC63:

Animal Model Products

miRNA for SEC63 Gene

miRTarBase miRNAs that target SEC63

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SEC63 Gene

Localization for SEC63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC63 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC63 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum TAS 10799540
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA,IDA 22375059
genes like me logo Genes that share ontologies with SEC63: view

Pathways & Interactions for SEC63 Gene

genes like me logo Genes that share pathways with SEC63: view

Gene Ontology (GO) - Biological Process for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006612 protein targeting to membrane TAS 10799540
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IMP 22375059
GO:0006620 posttranslational protein targeting to membrane IMP 22375059
GO:0006807 nitrogen compound metabolic process IEA --
genes like me logo Genes that share ontologies with SEC63: view

No data available for SIGNOR curated interactions for SEC63 Gene

Transcripts for SEC63 Gene

Unigene Clusters for SEC63 Gene

SEC63 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC63 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -
SP3:

Relevant External Links for SEC63 Gene

GeneLoc Exon Structure for
SEC63
ECgene alternative splicing isoforms for
SEC63

Expression for SEC63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC63 Gene

This gene is overexpressed in Nasal epithelium (22.1) and Pancreas (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC63 Gene



Protein tissue co-expression partners for SEC63 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC63 Gene:

SEC63

SOURCE GeneReport for Unigene cluster for SEC63 Gene:

Hs.26904

mRNA Expression by UniProt/SwissProt for SEC63 Gene:

Q9UGP8-SEC63_HUMAN
Tissue specificity: Widely expressed, with high levels in the liver.
genes like me logo Genes that share expression patterns with SEC63: view

No data available for mRNA differential expression in normal tissues for SEC63 Gene

Orthologs for SEC63 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC63 34 35
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia SEC63 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC63 34 35
  • 94.53 (n)
cow
(Bos Taurus)
Mammalia SEC63 34 35
  • 94.04 (n)
mouse
(Mus musculus)
Mammalia Sec63 34 16 35
  • 91.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SEC63 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec63 34
  • 89.94 (n)
chicken
(Gallus gallus)
Aves SEC63 34 35
  • 83.36 (n)
lizard
(Anolis carolinensis)
Reptilia SEC63 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec63 34
  • 77.14 (n)
Str.10109 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8341 34
zebrafish
(Danio rerio)
Actinopterygii sec63 34 35
  • 68.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec63 34 35
  • 50.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007361 34
  • 50.71 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-29 34 35
  • 50.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC63 35 37
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6082 35
  • 44 (a)
OneToOne
Species where no ortholog for SEC63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC63 Gene

ENSEMBL:
Gene Tree for SEC63 (if available)
TreeFam:
Gene Tree for SEC63 (if available)

Paralogs for SEC63 Gene

Pseudogenes.org Pseudogenes for SEC63 Gene

genes like me logo Genes that share paralogs with SEC63: view

No data available for Paralogs for SEC63 Gene

Variants for SEC63 Gene

Sequence variations from dbSNP and Humsavar for SEC63 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs119103233 Pathogenic 107,929,466(-) TATGT(A/G)GTATC reference, stop-gained, utr-variant-5-prime
rs727504146 Pathogenic 107,957,901(-) GGCCC(-/C)GAGAT upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs797044656 Pathogenic 107,893,550(-) AAAAA(-/A)CCTAC reference, frameshift-variant
rs869312977 Pathogenic 107,921,796(-) GCTGC(A/G)TAAGT splice-donor-variant
rs869312978 Pathogenic 107,929,419(-) CTACA(-/G)TAAAG reference, frameshift-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SEC63 Gene

Variant ID Type Subtype PubMed ID
nsv957547 CNV deletion 24416366
nsv830765 CNV loss 17160897
nsv823816 CNV loss 20364138
nsv348411 CNV deletion 16902084
nsv1114863 CNV deletion 24896259
nsv1073582 CNV deletion 25765185
nsv1030653 CNV gain 25217958
esv7155 CNV loss 19470904
esv3718 CNV loss 18987735
esv3610305 CNV loss 21293372
esv3540285 CNV deletion 23714750
esv2732554 CNV deletion 23290073
esv2677459 CNV deletion 23128226
esv2513800 CNV deletion 19546169
esv2438036 CNV deletion 19546169
esv2274293 CNV deletion 18987734
esv1260742 CNV deletion 17803354
dgv3361n106 CNV deletion 24896259

Variation tolerance for SEC63 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC63 Gene

Human Gene Mutation Database (HGMD)
SEC63
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC63 Gene

Disorders for SEC63 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEC63 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
polycystic liver disease
  • isolated autosomal dominant polycystic liver disease
- elite association - COSMIC cancer census association via MalaCards
Search SEC63 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SEC63_HUMAN
  • Polycystic liver disease 2 (PCLD2) [MIM:617004]: An autosomal dominant hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. {ECO:0000269 PubMed:15133510}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SEC63

Genetic Association Database (GAD)
SEC63
Human Genome Epidemiology (HuGE) Navigator
SEC63
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC63
genes like me logo Genes that share disorders with SEC63: view

No data available for Genatlas for SEC63 Gene

Publications for SEC63 Gene

  1. Extensive mutational analysis of PRKCSH and SEC63 broadens the spectrum of polycystic liver disease. (PMID: 16835903) Waanders E. … Drenth J.P. (Hum. Mutat. 2006) 3 22 46 64
  2. Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog. (PMID: 10543453) Skowronek M.H. … Haas I.G. (Biol. Chem. 1999) 2 3 4 64
  3. Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins. (PMID: 23166619) Mades A. … Prange R. (PLoS ONE 2012) 2 3 64
  4. Patients with isolated polycystic liver disease referred to liver centres: clinical characterization of 137 cases. (PMID: 20408955) Van Keimpema L. … Drenth J.P. (Liver Int. 2011) 3 46 64
  5. Cysts of PRKCSH mutated polycystic liver disease patients lack hepatocystin but express Sec63p. (PMID: 18224332) Waanders E. … Drenth J.P. (Histochem. Cell Biol. 2008) 3 22 64

Products for SEC63 Gene

Sources for SEC63 Gene

Content
Loading form....