Aliases for SEC63 Gene
External Ids for SEC63 Gene
Previous GeneCards Identifiers for SEC63 Gene
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEC63 Gene
SEC63 (SEC63 Homolog, Protein Translocation Regulator) is a Protein Coding gene. Diseases associated with SEC63 include Polycystic Liver Disease 2 and Polycystic Liver Disease. Among its related pathways are Protein processing in endoplasmic reticulum and Unfolded Protein Response (UPR). GO annotations related to this gene include poly(A) RNA binding and receptor activity.
UniProtKB/Swiss-Prot for SEC63 Gene
Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.