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Aliases for SEC63 Gene

Aliases for SEC63 Gene

  • SEC63 Homolog (S. Cerevisiae) 2 3
  • SEC63L 3 4
  • Translocation Protein SEC63 Homolog 3
  • SEC63-Like (S. Cerevisiae) 2
  • DNAJC23 3
  • PRO2507 3
  • ERdj2 3

External Ids for SEC63 Gene

Previous GeneCards Identifiers for SEC63 Gene

  • GC06M108192
  • GC06M108237
  • GC06M108298
  • GC06M105758
  • GC06M108188

Summaries for SEC63 Gene

Entrez Gene Summary for SEC63 Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC63 Gene

SEC63 (SEC63 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with SEC63 include polycystic liver disease and liver disease. Among its related pathways are Protein processing in endoplasmic reticulum and Protein export. GO annotations related to this gene include receptor activity and protein transporter activity.

UniProtKB/Swiss-Prot for SEC63 Gene

  • Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane

Gene Wiki entry for SEC63 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC63 Gene

Genomics for SEC63 Gene

Regulatory Elements for SEC63 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC63 Gene

107,867,756 bp from pter
107,958,278 bp from pter
90,523 bases
Minus strand

Genomic View for SEC63 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC63 Gene

Proteins for SEC63 Gene

  • Protein details for SEC63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Translocation protein SEC63 homolog
    Protein Accession:
    Secondary Accessions:
    • O95380
    • Q5THN4
    • Q86VS9
    • Q8IWL0
    • Q9NTE0

    Protein attributes for SEC63 Gene

    760 amino acids
    Molecular mass:
    87997 Da
    Quaternary structure:
    • Part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63
    • Sequence=AAH23598.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for SEC63 Gene

Proteomics data for SEC63 Gene at MOPED

Post-translational modifications for SEC63 Gene

  • Ubiquitination at Lys135, Lys147, Lys300, Lys381, Lys407, Lys633, Lys688, and Lys710
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC63 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SEC63 Gene

Domains for SEC63 Gene

Gene Families for SEC63 Gene

  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for SEC63 Gene

Suggested Antigen Peptide Sequences for SEC63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UGP8
  • Contains 1 J domain.
  • Contains 2 SEC63 domains.
genes like me logo Genes that share domains with SEC63: view

Function for SEC63 Gene

Molecular function for SEC63 Gene

GENATLAS Biochemistry:
S cerevisiae SEC63P homolog rough,endoplamic reticulum integral membrane protein,component of the transmembrane complex that mediates posttranslational translocation of nescent peptides across the ER
UniProtKB/Swiss-Prot Function:
Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane

Gene Ontology (GO) - Molecular Function for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10799540
GO:0005488 binding --
GO:0005515 protein binding IPI 21251912
GO:0008565 protein transporter activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SEC63: view
genes like me logo Genes that share phenotypes with SEC63: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC63

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC63 Gene

Localization for SEC63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC63 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SEC63 Gene COMPARTMENTS Subcellular localization image for SEC63 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005783 endoplasmic reticulum TAS 10799540
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
genes like me logo Genes that share ontologies with SEC63: view

Pathways for SEC63 Gene

genes like me logo Genes that share pathways with SEC63: view

Pathways by source for SEC63 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006612 protein targeting to membrane TAS 10799540
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IMP 22375059
GO:0006620 posttranslational protein targeting to membrane IMP 22375059
GO:0006807 nitrogen compound metabolic process IEA --
genes like me logo Genes that share ontologies with SEC63: view

Transcripts for SEC63 Gene

Unigene Clusters for SEC63 Gene

SEC63 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC63

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC63 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: -

Relevant External Links for SEC63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC63 Gene

mRNA expression in normal human tissues for SEC63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SEC63 Gene

This gene is overexpressed in Nasal epithelium (22.1) and Pancreas (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC63 Gene

SOURCE GeneReport for Unigene cluster for SEC63 Gene Hs.26904

mRNA Expression by UniProt/SwissProt for SEC63 Gene

Tissue specificity: Widely expressed, with high levels in the liver.
genes like me logo Genes that share expressions with SEC63: view

Expression partners for SEC63 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SEC63 Gene

Orthologs for SEC63 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC63 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEC63 35
  • 94.04 (n)
  • 98.42 (a)
SEC63 36
  • 98 (a)
(Canis familiaris)
Mammalia SEC63 35
  • 94.53 (n)
  • 97.36 (a)
SEC63 36
  • 98 (a)
(Mus musculus)
Mammalia Sec63 35
  • 91.6 (n)
  • 96.5 (a)
Sec63 16
Sec63 36
  • 96 (a)
(Pan troglodytes)
Mammalia SEC63 35
  • 99.74 (n)
  • 99.74 (a)
SEC63 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sec63 35
  • 89.94 (n)
  • 96.19 (a)
(Monodelphis domestica)
Mammalia SEC63 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia SEC63 36
  • 91 (a)
(Gallus gallus)
Aves SEC63 35
  • 83.36 (n)
  • 91.5 (a)
SEC63 36
  • 92 (a)
(Anolis carolinensis)
Reptilia SEC63 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec63 35
  • 77.14 (n)
  • 85.24 (a)
Str.10109 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8341 35
(Danio rerio)
Actinopterygii sec63 35
  • 68.57 (n)
  • 72.21 (a)
sec63 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007361 35
  • 50.71 (n)
  • 44.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec63 35
  • 50.93 (n)
  • 46.65 (a)
sec63 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea dnj-29 35
  • 50.14 (n)
  • 37.22 (a)
dnj-29 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC63 36
  • 22 (a)
SEC63 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6082 36
  • 44 (a)
Species with no ortholog for SEC63:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC63 Gene

Gene Tree for SEC63 (if available)
Gene Tree for SEC63 (if available)

Paralogs for SEC63 Gene Pseudogenes for SEC63 Gene

genes like me logo Genes that share paralogs with SEC63: view

No data available for Paralogs for SEC63 Gene

Variants for SEC63 Gene

Sequence variations from dbSNP and Humsavar for SEC63 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1826 -- 107,869,914(+) AAAAA(A/C)AACTT utr-variant-3-prime
rs483977 -- 107,907,796(+) TTAAT(A/T)ACAAC intron-variant
rs485736 -- 107,907,648(+) CAGAC(C/T)TTGGT intron-variant
rs488399 -- 107,876,064(-) TTTTT(A/G)TGTGT intron-variant
rs494630 -- 107,872,521(-) TTAGA(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC63 Gene

Variant ID Type Subtype PubMed ID
nsv830765 CNV Loss 17160897
nsv823816 CNV Loss 20364138
esv2677459 CNV Deletion 23128226
esv2438036 CNV Deletion 19546169
esv2274293 CNV Deletion 18987734
esv2732554 CNV Deletion 23290073
esv3718 CNV Deletion 18987735
esv2513800 CNV Deletion 19546169
esv7155 CNV Loss 19470904
esv1260742 CNV Deletion 17803354
nsv348411 CNV Loss 16902084

Relevant External Links for SEC63 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC63 Gene

Disorders for SEC63 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SEC63 Gene in MalaCards »

(2) Diseases for SEC63 Gene including...

(1) OMIM Diseases for SEC63 Gene (608648)


  • Polycystic liver disease (PCLD) [MIM:174050]: A hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. {ECO:0000269 PubMed:15133510}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SEC63 Gene

(2) Novoseek inferred disease relationships for SEC63 Gene

Disease -log(P) Hits PubMed IDs
polycystic liver disease 94.8 5
cysts 51.1 2

Relevant External Links for SEC63

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SEC63: view

No data available for Genatlas for SEC63 Gene

Publications for SEC63 Gene

  1. Extensive mutational analysis of PRKCSH and SEC63 broadens the spectrum of polycystic liver disease. (PMID: 16835903) Waanders E. … Drenth J.P. (Hum. Mutat. 2006) 3 23 48
  2. Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog. (PMID: 10543453) Skowronek M.H. … Haas I.G. (Biol. Chem. 1999) 2 3 4
  3. Mammalian Sec61 is associated with Sec62 and Sec63. (PMID: 10799540) Meyer H.-A. … Hartmann E. (J. Biol. Chem. 2000) 3 4
  4. Mutations in SEC63 cause autosomal dominant polycystic liver disease. (PMID: 15133510) Davila S. … Somlo S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SEC63 Gene

Sources for SEC63 Gene

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