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Aliases for SEC63 Gene

Aliases for SEC63 Gene

  • SEC63 Homolog, Protein Translocation Regulator 2 3 5
  • SEC63L 3 4
  • SEC63 Protein Translocation Regulator 3
  • Translocation Protein SEC63 Homolog 3
  • SEC63 Homolog (S. Cerevisiae) 2
  • SEC63-Like (S. Cerevisiae) 2
  • SEC63-Like Protein 3
  • SEC63 Homolog 3
  • DNAJC23 3
  • PRO2507 3
  • ERdj2 3
  • PCLD2 3

External Ids for SEC63 Gene

Previous GeneCards Identifiers for SEC63 Gene

  • GC06M108192
  • GC06M108237
  • GC06M108298
  • GC06M105758
  • GC06M108188

Summaries for SEC63 Gene

Entrez Gene Summary for SEC63 Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC63 Gene

SEC63 (SEC63 Homolog, Protein Translocation Regulator) is a Protein Coding gene. Diseases associated with SEC63 include Polycystic Liver Disease. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR). GO annotations related to this gene include poly(A) RNA binding and receptor activity.

UniProtKB/Swiss-Prot for SEC63 Gene

  • Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

Gene Wiki entry for SEC63 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC63 Gene

Genomics for SEC63 Gene

Regulatory Elements for SEC63 Gene

Enhancers for SEC63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SEC63 on UCSC Golden Path with GeneCards custom track

Promoters for SEC63 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SEC63 Gene

107,867,756 bp from pter
107,958,278 bp from pter
90,523 bases
Minus strand

Genomic View for SEC63 Gene

Genes around SEC63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC63 Gene

Proteins for SEC63 Gene

  • Protein details for SEC63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Translocation protein SEC63 homolog
    Protein Accession:
    Secondary Accessions:
    • O95380
    • Q5THN4
    • Q86VS9
    • Q8IWL0
    • Q9NTE0

    Protein attributes for SEC63 Gene

    760 amino acids
    Molecular mass:
    87997 Da
    Quaternary structure:
    • Part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63.
    • Sequence=AAH23598.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for SEC63 Gene

Post-translational modifications for SEC63 Gene

  • Ubiquitination at Lys 135, Lys 147, Lys 300, Lys 381, Lys 407, Lys 633, Lys 688, and Lys 710
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC63 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC63 Gene

Domains & Families for SEC63 Gene

Gene Families for SEC63 Gene

Protein Domains for SEC63 Gene

Suggested Antigen Peptide Sequences for SEC63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
  • Contains 2 SEC63 domains.
genes like me logo Genes that share domains with SEC63: view

Function for SEC63 Gene

Molecular function for SEC63 Gene

GENATLAS Biochemistry:
S cerevisiae SEC63P homolog rough,endoplamic reticulum integral membrane protein,component of the transmembrane complex that mediates posttranslational translocation of nescent peptides across the ER
UniProtKB/Swiss-Prot Function:
Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

Gene Ontology (GO) - Molecular Function for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10799540
GO:0005515 protein binding IPI 21251912
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SEC63: view
genes like me logo Genes that share phenotypes with SEC63: view

Human Phenotype Ontology for SEC63 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SEC63 Gene

MGI Knock Outs for SEC63:

Animal Model Products

CRISPR Products

miRNA for SEC63 Gene

miRTarBase miRNAs that target SEC63

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SEC63 Gene

Localization for SEC63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC63 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SEC63 Gene COMPARTMENTS Subcellular localization image for SEC63 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 10799540
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC63: view

Pathways & Interactions for SEC63 Gene

genes like me logo Genes that share pathways with SEC63: view

Gene Ontology (GO) - Biological Process for SEC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006612 protein targeting to membrane TAS 10799540
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA,IMP 22375059
GO:0006620 posttranslational protein targeting to membrane IEA,IMP 22375059
GO:0006807 nitrogen compound metabolic process IEA --
genes like me logo Genes that share ontologies with SEC63: view

No data available for SIGNOR curated interactions for SEC63 Gene

Drugs & Compounds for SEC63 Gene

No Compound Related Data Available

Transcripts for SEC63 Gene

Unigene Clusters for SEC63 Gene

SEC63 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC63 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: -

Relevant External Links for SEC63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC63 Gene

mRNA expression in normal human tissues for SEC63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC63 Gene

This gene is overexpressed in Nasal epithelium (22.1) and Pancreas (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC63 Gene

Protein tissue co-expression partners for SEC63 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC63 Gene:


SOURCE GeneReport for Unigene cluster for SEC63 Gene:


mRNA Expression by UniProt/SwissProt for SEC63 Gene:

Tissue specificity: Widely expressed, with high levels in the liver.
genes like me logo Genes that share expression patterns with SEC63: view

Primer Products

No data available for mRNA differential expression in normal tissues for SEC63 Gene

Orthologs for SEC63 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC63 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEC63 34
  • 94.04 (n)
  • 98.42 (a)
SEC63 35
  • 98 (a)
(Canis familiaris)
Mammalia SEC63 34
  • 94.53 (n)
  • 97.36 (a)
SEC63 35
  • 98 (a)
(Mus musculus)
Mammalia Sec63 34
  • 91.6 (n)
  • 96.5 (a)
Sec63 16
Sec63 35
  • 96 (a)
(Pan troglodytes)
Mammalia SEC63 34
  • 99.74 (n)
  • 99.74 (a)
SEC63 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Sec63 34
  • 89.94 (n)
  • 96.19 (a)
(Monodelphis domestica)
Mammalia SEC63 35
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia SEC63 35
  • 91 (a)
(Gallus gallus)
Aves SEC63 34
  • 83.36 (n)
  • 91.5 (a)
SEC63 35
  • 92 (a)
(Anolis carolinensis)
Reptilia SEC63 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec63 34
  • 77.14 (n)
  • 85.24 (a)
Str.10109 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8341 34
(Danio rerio)
Actinopterygii sec63 34
  • 68.57 (n)
  • 72.21 (a)
sec63 35
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007361 34
  • 50.71 (n)
  • 44.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec63 34
  • 50.93 (n)
  • 46.65 (a)
sec63 35
  • 43 (a)
(Caenorhabditis elegans)
Secernentea dnj-29 34
  • 50.14 (n)
  • 37.22 (a)
dnj-29 35
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC63 35
  • 22 (a)
SEC63 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6082 35
  • 44 (a)
Species where no ortholog for SEC63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC63 Gene

Gene Tree for SEC63 (if available)
Gene Tree for SEC63 (if available)

Paralogs for SEC63 Gene Pseudogenes for SEC63 Gene

genes like me logo Genes that share paralogs with SEC63: view

No data available for Paralogs for SEC63 Gene

Variants for SEC63 Gene

Sequence variations from dbSNP and Humsavar for SEC63 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17854547 - 107,893,490(+) CCCAA(C/T)GACTC reference, missense
rs847113 -- 107,898,327(+) gcatt(C/T)gcaca intron-variant
rs847114 -- 107,898,945(+) CAGCA(C/G)CTGGG intron-variant
rs847115 -- 107,899,074(+) GGTCA(C/T)GTGAA intron-variant
rs847116 -- 107,903,920(+) tgaga(C/T)cagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC63 Gene

Variant ID Type Subtype PubMed ID
dgv3361n106 CNV deletion 24896259
esv1260742 CNV deletion 17803354
esv2274293 CNV deletion 18987734
esv2438036 CNV deletion 19546169
esv2513800 CNV deletion 19546169
esv2677459 CNV deletion 23128226
esv2732554 CNV deletion 23290073
esv3540285 CNV deletion 23714750
esv3610305 CNV loss 21293372
esv3718 CNV loss 18987735
esv7155 CNV loss 19470904
nsv1030653 CNV gain 25217958
nsv1073582 CNV deletion 25765185
nsv1114863 CNV deletion 24896259
nsv348411 CNV deletion 16902084
nsv823816 CNV loss 20364138
nsv830765 CNV loss 17160897
nsv957547 CNV deletion 24416366

Variation tolerance for SEC63 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC63 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC63 Gene

Disorders for SEC63 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEC63 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
polycystic liver disease
  • isolated polycystic liver disease
- elite association - COSMIC cancer census association via MalaCards
Search SEC63 in MalaCards View complete list of genes associated with diseases


  • Polycystic liver disease (PCLD) [MIM:174050]: A hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. {ECO:0000269 PubMed:15133510}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SEC63

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SEC63: view

No data available for Genatlas for SEC63 Gene

Publications for SEC63 Gene

  1. Extensive mutational analysis of PRKCSH and SEC63 broadens the spectrum of polycystic liver disease. (PMID: 16835903) Waanders E. … Drenth J.P. (Hum. Mutat. 2006) 3 22 46 65
  2. Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog. (PMID: 10543453) Skowronek M.H. … Haas I.G. (Biol. Chem. 1999) 2 3 4 65
  3. Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins. (PMID: 23166619) Mades A. … Prange R. (PLoS ONE 2012) 2 3 65
  4. Patients with isolated polycystic liver disease referred to liver centres: clinical characterization of 137 cases. (PMID: 20408955) Van Keimpema L. … Drenth J.P. (Liver Int. 2011) 3 46 65
  5. Cysts of PRKCSH mutated polycystic liver disease patients lack hepatocystin but express Sec63p. (PMID: 18224332) Waanders E. … Drenth J.P. (Histochem. Cell Biol. 2008) 3 22 65

Products for SEC63 Gene

Sources for SEC63 Gene

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