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Aliases for SEC62 Gene

Aliases for SEC62 Gene

  • SEC62 Homolog, Preprotein Translocation Factor 2 3 5
  • Translocation Protein 1 2 3 4
  • TLOC1 3 4
  • HTP-1 3 4
  • TP-1 3 4
  • Membrane Protein SEC62, S.Cerevisiae, Homolog Of 3
  • SEC62 Preprotein Translocation Factor 3
  • SEC62 Homolog (S. Cerevisiae) 2
  • SEC62 Homolog 3
  • Dtrp1 3
  • HTP1 3

External Ids for SEC62 Gene

Previous HGNC Symbols for SEC62 Gene

  • TLOC1

Previous GeneCards Identifiers for SEC62 Gene

  • GC03P171167
  • GC03P169681
  • GC03P167054
  • GC03P169684

Summaries for SEC62 Gene

Entrez Gene Summary for SEC62 Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC62 Gene

SEC62 (SEC62 Homolog, Preprotein Translocation Factor) is a Protein Coding gene. Among its related pathways are Protein export and Protein processing in endoplasmic reticulum. GO annotations related to this gene include receptor activity and ATPase activity, coupled to transmembrane movement of substances.

UniProtKB/Swiss-Prot for SEC62 Gene

  • Required for preprotein translocation.

Gene Wiki entry for SEC62 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC62 Gene

Genomics for SEC62 Gene

Regulatory Elements for SEC62 Gene

Enhancers for SEC62 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEC62 on UCSC Golden Path with GeneCards custom track

Promoters for SEC62 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC62 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC62 Gene

Chromosome:
3
Start:
169,966,635 bp from pter
End:
169,998,373 bp from pter
Size:
31,739 bases
Orientation:
Plus strand

Genomic View for SEC62 Gene

Genes around SEC62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC62 Gene

Proteins for SEC62 Gene

  • Protein details for SEC62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99442-SEC62_HUMAN
    Recommended name:
    Translocation protein SEC62
    Protein Accession:
    Q99442
    Secondary Accessions:
    • D3DNQ0
    • O00682
    • O00729

    Protein attributes for SEC62 Gene

    Size:
    399 amino acids
    Molecular mass:
    45862 Da
    Quaternary structure:
    • Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B.

neXtProt entry for SEC62 Gene

Proteomics data for SEC62 Gene at MOPED

Post-translational modifications for SEC62 Gene

  • Ubiquitination at Lys 19, Lys 51, and Lys 60
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC62 Gene

Antibody Products

No data available for DME Specific Peptides for SEC62 Gene

Domains & Families for SEC62 Gene

Protein Domains for SEC62 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99442

UniProtKB/Swiss-Prot:

SEC62_HUMAN :
  • Belongs to the SEC62 family.
Family:
  • Belongs to the SEC62 family.
genes like me logo Genes that share domains with SEC62: view

No data available for Gene Families for SEC62 Gene

Function for SEC62 Gene

Molecular function for SEC62 Gene

UniProtKB/Swiss-Prot Function:
Required for preprotein translocation.

Gene Ontology (GO) - Molecular Function for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with SEC62: view
genes like me logo Genes that share phenotypes with SEC62: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC62 Gene

Localization for SEC62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC62 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC62 Gene COMPARTMENTS Subcellular localization image for SEC62 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endoplasmic reticulum 5
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005791 rough endoplasmic reticulum ISS --
GO:0005829 cytosol TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC62: view

Pathways & Interactions for SEC62 Gene

genes like me logo Genes that share pathways with SEC62: view

Gene Ontology (GO) - Biological Process for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with SEC62: view

No data available for SIGNOR curated interactions for SEC62 Gene

Drugs & Compounds for SEC62 Gene

No Compound Related Data Available

Transcripts for SEC62 Gene

Unigene Clusters for SEC62 Gene

SEC62 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC62 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2:

Relevant External Links for SEC62 Gene

GeneLoc Exon Structure for
SEC62
ECgene alternative splicing isoforms for
SEC62

Expression for SEC62 Gene

mRNA expression in normal human tissues for SEC62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC62 Gene

This gene is overexpressed in Nasal epithelium (41.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC62 Gene



SOURCE GeneReport for Unigene cluster for SEC62 Gene Hs.744859

genes like me logo Genes that share expression patterns with SEC62: view

Protein tissue co-expression partners for SEC62 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC62 Gene

Orthologs for SEC62 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC62 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC62 35
  • 95.41 (n)
  • 97.99 (a)
SEC62 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC62 35
  • 94.82 (n)
  • 97.74 (a)
-- 36
  • 92 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sec62 35
  • 90.79 (n)
  • 92.71 (a)
Sec62 16
Sec62 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC62 35
  • 99.92 (n)
  • 100 (a)
SEC62 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec62 35
  • 91.04 (n)
  • 92.71 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC62 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC62 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC62 35
  • 82.45 (n)
  • 90.93 (a)
SEC62 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC62 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec62 35
  • 76.62 (n)
  • 82.4 (a)
Str.3285 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23749 35
zebrafish
(Danio rerio)
Actinopterygii sec62 35
  • 71.91 (n)
  • 76.96 (a)
sec62 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14146 35
fruit fly
(Drosophila melanogaster)
Insecta Trp1 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C18E9.2 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC62 36
  • 23 (a)
OneToOne
SEC62 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9471 36
  • 31 (a)
OneToOne
Species with no ortholog for SEC62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC62 Gene

ENSEMBL:
Gene Tree for SEC62 (if available)
TreeFam:
Gene Tree for SEC62 (if available)

Paralogs for SEC62 Gene

(1) SIMAP similar genes for SEC62 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SEC62: view

No data available for Paralogs for SEC62 Gene

Variants for SEC62 Gene

Sequence variations from dbSNP and Humsavar for SEC62 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3348 -- 169,996,354(-) TACTG(C/T)GGAAA utr-variant-3-prime
rs9416 -- 169,995,944(-) aaggg(C/T)aaaaa utr-variant-3-prime
rs10325 -- 169,993,931(+) GAACA(C/T)CTGTG utr-variant-3-prime
rs1043961 -- 169,993,177(+) ACTGA(A/G)ATGTA utr-variant-3-prime
rs2287484 -- 169,986,246(-) AACAA(C/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC62 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877976 CNV Gain 21882294
esv270037 CNV Insertion 20981092
esv2494675 CNV Insertion 19546169

Variation tolerance for SEC62 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC62 Gene

HapMap Linkage Disequilibrium report
SEC62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC62 Gene

Disorders for SEC62 Gene

Relevant External Links for SEC62

Genetic Association Database (GAD)
SEC62
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC62

No disorders were found for SEC62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC62 Gene

Publications for SEC62 Gene

  1. Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp-1). (PMID: 9020021) Daimon M. … Sasaki H. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. Different effects of Sec61I+, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. (PMID: 22375059) Lang S. … Dudek J. (J. Cell. Sci. 2012) 2 3
  3. Mammalian Sec61 is associated with Sec62 and Sec63. (PMID: 10799540) Meyer H.-A. … Hartmann E. (J. Biol. Chem. 2000) 2 3
  4. Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene. (PMID: 10683767) Daimon M. … Kato T. (IUBMB Life 1999) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SEC62 Gene

Sources for SEC62 Gene

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