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Aliases for SEC62 Gene

Aliases for SEC62 Gene

  • SEC62 Homolog (S. Cerevisiae) 2 3
  • Translocation Protein 1 2 3 4
  • TLOC1 3 4 6
  • HTP-1 3 4
  • HTP1 3 6
  • TP-1 3 4
  • Membrane Protein SEC62, S.Cerevisiae, Homolog Of 3
  • Translocation Protein SEC62 3
  • Dtrp1 3

External Ids for SEC62 Gene

Previous HGNC Symbols for SEC62 Gene

  • TLOC1

Previous GeneCards Identifiers for SEC62 Gene

  • GC03P171167
  • GC03P169681
  • GC03P167054
  • GC03P169684

Summaries for SEC62 Gene

Entrez Gene Summary for SEC62 Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC62 Gene

SEC62 (SEC62 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Protein export. GO annotations related to this gene include receptor activity and protein transporter activity.

UniProtKB/Swiss-Prot for SEC62 Gene

  • Required for preprotein translocation.

Gene Wiki entry for SEC62 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC62 Gene

Genomics for SEC62 Gene

Regulatory Elements for SEC62 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC62 Gene

169,966,635 bp from pter
169,998,373 bp from pter
31,739 bases
Plus strand

Genomic View for SEC62 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC62 Gene

Proteins for SEC62 Gene

  • Protein details for SEC62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Translocation protein SEC62
    Protein Accession:
    Secondary Accessions:
    • D3DNQ0
    • O00682
    • O00729

    Protein attributes for SEC62 Gene

    399 amino acids
    Molecular mass:
    45862 Da
    Quaternary structure:
    • Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B.

neXtProt entry for SEC62 Gene

Proteomics data for SEC62 Gene at MOPED

Post-translational modifications for SEC62 Gene

  • Ubiquitination at Lys19, Lys51, and Lys60
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC62 Gene

Antibody Products

No data available for DME Specific Peptides for SEC62 Gene

Domains for SEC62 Gene

Protein Domains for SEC62 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q99442
  • Belongs to the SEC62 family.
genes like me logo Genes that share domains with SEC62: view

No data available for Gene Families for SEC62 Gene

Function for SEC62 Gene

Molecular function for SEC62 Gene

UniProtKB/Swiss-Prot Function:
Required for preprotein translocation.

Gene Ontology (GO) - Molecular Function for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9020021
GO:0005524 ATP binding --
GO:0008565 protein transporter activity IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances --
genes like me logo Genes that share ontologies with SEC62: view

Phenotypes for SEC62 Gene

genes like me logo Genes that share phenotypes with SEC62: view

Animal Model Products

miRNA for SEC62 Gene

miRTarBase miRNAs that target SEC62

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC62

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC62 Gene

Localization for SEC62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC62 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SEC62 Gene COMPARTMENTS Subcellular localization image for SEC62 gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 4
plasma membrane 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005791 rough endoplasmic reticulum ISS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
genes like me logo Genes that share ontologies with SEC62: view

Pathways for SEC62 Gene

genes like me logo Genes that share pathways with SEC62: view

Pathways by source for SEC62 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 9020021
GO:0006620 posttranslational protein targeting to membrane IMP 22375059
GO:0006810 transport --
GO:0015031 protein transport --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
genes like me logo Genes that share ontologies with SEC62: view

Transcripts for SEC62 Gene

Unigene Clusters for SEC62 Gene

SEC62 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC62

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC62 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b

Relevant External Links for SEC62 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC62 Gene

mRNA expression in normal human tissues for SEC62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SEC62 Gene

This gene is overexpressed in Nasal epithelium (41.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC62 Gene

SOURCE GeneReport for Unigene cluster for SEC62 Gene Hs.744859

genes like me logo Genes that share expressions with SEC62: view

Expression partners for SEC62 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC62 Gene

Orthologs for SEC62 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC62 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEC62 35
  • 95.41 (n)
  • 97.99 (a)
SEC62 36
  • 96 (a)
(Canis familiaris)
Mammalia SEC62 35
  • 94.82 (n)
  • 97.74 (a)
-- 36
  • 92 (a)
-- 36
  • 98 (a)
(Mus musculus)
Mammalia Sec62 35
  • 90.79 (n)
  • 92.71 (a)
Sec62 16
Sec62 36
  • 94 (a)
(Pan troglodytes)
Mammalia SEC62 35
  • 99.92 (n)
  • 100 (a)
SEC62 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sec62 35
  • 91.04 (n)
  • 92.71 (a)
(Monodelphis domestica)
Mammalia SEC62 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SEC62 36
  • 87 (a)
(Gallus gallus)
Aves SEC62 35
  • 82.45 (n)
  • 90.93 (a)
SEC62 36
  • 91 (a)
(Anolis carolinensis)
Reptilia SEC62 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec62 35
  • 76.62 (n)
  • 82.4 (a)
Str.3285 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23749 35
(Danio rerio)
Actinopterygii sec62 35
  • 71.91 (n)
  • 76.96 (a)
sec62 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14146 35
fruit fly
(Drosophila melanogaster)
Insecta Trp1 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C18E9.2 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC62 36
  • 23 (a)
SEC62 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9471 36
  • 31 (a)
Species with no ortholog for SEC62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC62 Gene

Gene Tree for SEC62 (if available)
Gene Tree for SEC62 (if available)

Paralogs for SEC62 Gene

Selected SIMAP similar genes for SEC62 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SEC62: view

No data available for Paralogs for SEC62 Gene

Variants for SEC62 Gene

Sequence variations from dbSNP and Humsavar for SEC62 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3348 -- 169,996,354(-) TACTG(C/T)GGAAA utr-variant-3-prime
rs9416 -- 169,995,944(-) aaggg(C/T)aaaaa utr-variant-3-prime
rs10325 -- 169,993,931(+) GAACA(C/T)CTGTG utr-variant-3-prime
rs1043961 -- 169,993,177(+) ACTGA(A/G)ATGTA utr-variant-3-prime
rs1132237 -- 169,995,695(+) agtta(C/T)gttct utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEC62 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877976 CNV Gain 21882294
esv270037 CNV Insertion 20981092
esv2494675 CNV Insertion 19546169

Relevant External Links for SEC62 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC62 Gene

Disorders for SEC62 Gene

Relevant External Links for SEC62

Genetic Association Database (GAD)

No disorders were found for SEC62 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SEC62 Gene

Publications for SEC62 Gene

  1. Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp-1). (PMID: 9020021) Daimon M. … Sasaki H. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene. (PMID: 10683767) Daimon M. … Kato T. (IUBMB Life 1999) 3 4 23
  3. Mammalian Sec61 is associated with Sec62 and Sec63. (PMID: 10799540) Meyer H.-A. … Hartmann E. (J. Biol. Chem. 2000) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for SEC62 Gene

Sources for SEC62 Gene

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