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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC62 Gene

protein-coding   GIFtS: 54
GCID: GC03P169684

SEC62 Homolog (S. Cerevisiae)

(Previous name: translocation protein 1)
(Previous symbol: TLOC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SEC62 Homolog (S. Cerevisiae)1 2     HTP12 5
TLOC11 2 3 5     Dtrp12
Translocation Protein 11 2 3     Membrane Protein SEC62, S.Cerevisiae, Homolog Of2
TP-12 3     Translocation Protein SEC622
hTP-12 3     

External Ids:    HGNC: 118461   Entrez Gene: 70952   Ensembl: ENSG000000089527   OMIM: 6021735   UniProtKB: Q994423   

Export aliases for SEC62 gene to outside databases

Previous GC identifers: GC03P171167 GC03P169681 GC03P167054


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC62 Gene:
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum
(ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free
SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into
the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject
to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein
located in the rough ER. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEC62 Gene: 
SEC62 (SEC62 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SEC62 include polycystic liver disease, and liver disease. GO annotations related to this gene include protein transporter activity and receptor activity.

UniProtKB/Swiss-Prot: SEC62_HUMAN, Q99442
Function: Required for preprotein translocation (By similarity)

Gene Wiki entry for SEC62 (TLOC1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC62 gene promoter:
         TBP   FOXD3   FOXD1   POU6F1 (c2)   c-Ets-1   Evi-1   Pax-3   SRY   Nkx6-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SEC62 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC62

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2

SEC62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC62 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P169684:  view genomic region     (about GC identifiers)

Start:
169,684,423 bp from pter      End:
169,716,161 bp from pter
Size:
31,739 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEC62_HUMAN, Q99442 (See protein sequence)
Recommended Name: Translocation protein SEC62  
Size: 399 amino acids; 45862 Da
Subunit: Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: D3DNQ0 O00682 O00729

Explore the universe of human proteins at neXtProt for SEC62: NX_Q99442

Explore proteomics data for SEC62 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99442

  • SEC62 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEC62 Protein Expression
    REFSEQ proteins: NP_003253.1  
    ENSEMBL proteins: 
     ENSP00000337688   ENSP00000419319   ENSP00000420331   ENSP00000420304   ENSP00000418342  

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    Novus Biologicals SEC62 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005791rough endoplasmic reticulum ISS--
    GO:0016020membrane IDA--
    GO:0016021integral to membrane IEA--

    SEC62 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004728 Sec62

    Graphical View of Domain Structure for InterPro Entry Q99442

    ProtoNet protein and cluster: Q99442

    UniProtKB/Swiss-Prot: SEC62_HUMAN, Q99442
    Similarity: Belongs to the SEC62 family


    SEC62 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEC62_HUMAN, Q99442
    Function: Required for preprotein translocation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9020021
    GO:0005524ATP binding ----
    GO:0008565protein transporter activity IEA--
    GO:0042626ATPase activity, coupled to transmembrane movement of substances ----
         
    SEC62 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SEC62:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEC62 
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    miRNA
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    miRTarBase miRNAs that target SEC62:
    hsa-mir-30a (MIRT005126)

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    8/129 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC62 (see all 129):
    hsa-miR-4305 hsa-miR-134 hsa-miR-3653 hsa-miR-3116 hsa-miR-525-3p hsa-miR-520b hsa-miR-186* hsa-miR-519e
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEC62 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    2Protein export
    Protein export

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for SEC62):
        Protein export
    Protein processing in endoplasmic reticulum


    SEC62 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC62

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for SEC62 (Q994422, 3 ENSP000003376884) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CICQ96RK02, 3, ENSP000001607404MINT-2863613 I2D: score=3 STRING: ENSP00000160740
    SEC63Q9UGP83, ENSP000003579984I2D: score=2 STRING: ENSP00000357998
    GRB2P629933I2D: score=2 
    PCBD1P614573I2D: score=1 
    ZNF24P170283I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006613cotranslational protein targeting to membrane TAS9020021
    GO:0006620posttranslational protein targeting to membrane IMP--
    GO:0006810transport ----
    GO:0015031protein transport ----
    GO:0055085transmembrane transport ----

    SEC62 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC62

    Search CenterWatch for drugs/clinical trials and news about SEC62

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC62 gene: 
    NM_003262.3  

    Unigene Cluster for SEC62:

    SEC62 homolog (S. cerevisiae)
    Hs.744859  [show with all ESTs]
    Unigene Representative Sequence: NM_003262
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461933 ENST00000337002(uc003fgg.3 uc003fgh.3) ENST00000460513
    ENST00000480708 ENST00000487736 ENST00000469515 ENST00000481435 ENST00000497277
    ENST00000469890 ENST00000470355
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC62
    8/129 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC62 (see all 129):
    hsa-miR-4305 hsa-miR-134 hsa-miR-3653 hsa-miR-3116 hsa-miR-525-3p hsa-miR-520b hsa-miR-186* hsa-miR-519e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC62
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC62
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC62

    Additional mRNA sequence: 

    AK025548.1 AK057365.1 AK294504.1 BC003677.1 BC007040.1 BC012035.1 BC089399.1 BC105971.1 
    BX648539.1 D87127.1 U93239.1 

    24/26 DOTS entries (see all 26):

    DT.95307825  DT.95143221  DT.97864960  DT.120848128  DT.217832  DT.100039497  DT.95368164  DT.100035533 
    DT.100886710  DT.86846533  DT.100039494  DT.309921  DT.75135029  DT.91751812  DT.120848150  DT.91751804 
    DT.100886718  DT.120848043  DT.120848117  DT.120848122  DT.120848146  DT.120848202  DT.91702511  DT.91751803 

    24/566 AceView cDNA sequences (see all 566):

    BM126736 AI435560 NM_003262 AA236805 BI792842 AI825143 AI632792 BM127035 
    T35228 AI090964 AA987782 F28821 AA773901 BM126769 AA031542 BU902397 
    AU130253 AI268867 AA232670 AI150698 N74523 AA788660 BQ010442 CD108775 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SEC62    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                            
    SP2:                                                            


    ECgene alternative splicing isoforms for SEC62

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC62 expression in normal human tissues (normalized intensities)      SEC62 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEC62 Expression
    About this image


    SEC62 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad

    See SEC62 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC62

    SOURCE GeneReport for Unigene cluster: Hs.744859
        SABiosciences Expression via Pathway-Focused PCR Arrays including SEC62: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC62 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec621 , 5 SEC62 homolog (S. cerevisiae)1, 5 91.62(n)1
    93.97(a)1
      3 (14.29 cM)5
    692761  NM_027016.21  NP_081292.11 
     307928765 
    chicken
    (Gallus gallus)
    Aves SEC621 SEC62 homolog (S. cerevisiae) 83.5(n)
    92.17(a)
      424993  NM_001012602.1  NP_001012620.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC626
    Uncharacterized protein
    86(a)
    1 ↔ 1
    3(7851801-7866557)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237492 Xenopus laevis transcribed sequence with moderate similarity more 82.22(n)    BJ069499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sec621 SEC62 homolog (S. cerevisiae) 75.34(n)
    82.04(a)
      563660  NM_001025530.1  NP_001020701.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trp11 Translocation protein 1 49(n)
    38.64(a)
      34333  NM_057660.3  NP_477008.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C18E9.21 Protein C18E9.2 53.52(n)
    43.79(a)
      174429  NM_063507.4  NP_495908.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC62(YPL094C)4 Essential subunit of Sec63 complex (Sec63p, Sec62p, more   --   16(370663-369839) 856011  NP_015231.2 


    ENSEMBL Gene Tree for SEC62 (if available)
    TreeFam Gene Tree for SEC62 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC62 gene
    1 SIMAP similar gene for SEC62 using alignment to 6 protein entries:     SEC62_HUMAN (see all proteins):
    TLOC1

    SEC62 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/602 SNPs in SEC62 are shown (see all 602)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730439271,2
    C,F--169686837(+) TAATGG/AAAAGT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs345923751,2
    C--169687034(+) AAAAA-/AGTAGC 1 -- int10--------
    rs1410140211,2
    C--169687044(+) AAAAA-/GTAGCT 1 -- int10--------
    rs793037791,2
    C,F--169687227(+) GCTGCA/GTAGTA 1 -- int11Minor allele frequency- G:0.09WA 118
    rs1809708751,2
    --169687236(+) TAGAAA/GTTGAT 1 -- int10--------
    rs172894941,2
    C,F--169687277(+) TTTAAA/GAGGAT 1 -- int13Minor allele frequency- G:0.02NA 142
    rs113037901,2
    C--169687304(+) GAAGC-/CTTTTT 1 -- int10--------
    rs2001968921,2
    --169687306(+) AAGCC-/TTTTTC 1 -- int10--------
    rs781367981,2
    C,F--169687354(+) CTACAG/ACTGAC 1 -- int11Minor allele frequency- A:0.03EA 120
    rs730439281,2
    C--169687379(+) ACCCTC/TGTTTT 1 -- int13Minor allele frequency- T:0.06WA EA 240

    HapMap Linkage Disequilibrium report for SEC62 (169684423 - 169716161 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEC62:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2494675CNV Insertion19546169
    esv270037CNV Insertion20981092
    nsv877976CNV Gain21882294
    nsv7356OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC62
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC62

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602173    OMIM disorders: --

    6 diseases for SEC62:    About MalaCards
    polycystic liver disease    liver disease    prostate cancer    prostatitis
    hepatocellular carcinoma    lung cancer


    SEC62 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEC62

    Export disorders for SEC62 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC62 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with SEC62)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp-1). (PubMed id 9020021)1, 2, 3, 9 Daimon M.... Sasaki H. (1997)
    2. Mammalian Sec61 is associated with Sec62 and Sec63. (PubMed id 10799540)1, 2, 3 Meyer H.A....Hartmann E. (2000)
    3. Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene. (PubMed id 10683767)1, 2, 9 Daimon M.... Kato T. (1999)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. CK2 phosphorylation of human Sec63 regulates its inter action with Sec62. (PubMed id 23287549)1 Ampofo E....Montenarh M. (2013)
    7. Efficient secretion of small proteins in mammalian cel ls relies on Sec62-dependent posttranslational translocation. (PubMed id 22648169)1 Lakkaraju A.K....Strub K. (2012)
    8. Identification of cyclin B1 and Sec62 as biomarkers fo r recurrence in patients with HBV-related hepatocellular carcinoma after surgica l resection. (PubMed id 22682366)1 Weng L....Ling C. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Sec62 bridges the gap from 3q amplification to molecul ar cell biology in non-small cell lung cancer. (PubMed id 22197383)1 Linxweiler M....Greiner M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7095 HGNC: 11846 AceView: TLOC1 Ensembl:ENSG00000008952 euGenes: HUgn7095
    ECgene: SEC62 Kegg: 7095 H-InvDB: SEC62

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC62 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC62 gene:
    Search GeneIP for patents involving SEC62

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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