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SEC62 Gene

protein-coding   GIFtS: 51
GCID: GC03P169684

SEC62 Homolog (S. Cerevisiae)

(Previous name: translocation protein 1)
(Previous symbol: TLOC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SEC62 Homolog (S. Cerevisiae)1 2     HTP12 5
TLOC11 2 3 5     Dtrp12
Translocation Protein 11 2 3     Membrane Protein SEC62, S.Cerevisiae, Homolog Of2
TP-12 3     Translocation Protein SEC622
hTP-12 3     

External Ids:    HGNC: 118461   Entrez Gene: 70952   Ensembl: ENSG000000089527   OMIM: 6021735   UniProtKB: Q994423   

Export aliases for SEC62 gene to outside databases

Previous GC identifers: GC03P171167 GC03P169681 GC03P167054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEC62 Gene:
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum
(ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free
SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into
the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject
to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein
located in the rough ER. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEC62 Gene:
SEC62 (SEC62 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SEC62 include polycystic liver disease, and liver disease. GO annotations related to this gene include protein transporter activity and receptor activity.

UniProtKB/Swiss-Prot: SEC62_HUMAN, Q99442
Function: Required for preprotein translocation (By similarity)

Gene Wiki entry for SEC62 (TLOC1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SEC62 gene promoter:
         TBP   FOXD3   FOXD1   POU6F1 (c2)   c-Ets-1   Evi-1   Pax-3   SRY   Nkx6-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SEC62 promoter sequence
   Search Chromatin IP Primers for SEC62

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2

SEC62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC62 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P169684:  view genomic region     (about GC identifiers)

Start:
169,684,423 bp from pter      End:
169,716,161 bp from pter
Size:
31,739 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SEC62_HUMAN, Q99442 (See protein sequence)
Recommended Name: Translocation protein SEC62  
Size: 399 amino acids; 45862 Da
Subunit: Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B
Secondary accessions: D3DNQ0 O00682 O00729

Explore the universe of human proteins at neXtProt for SEC62: NX_Q99442

Explore proteomics data for SEC62 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19, Lys51, Lys60
  • Modification sites at PhosphoSitePlus

  • See SEC62 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003253.1  
    ENSEMBL proteins: 
     ENSP00000337688   ENSP00000419319   ENSP00000420331   ENSP00000420304   ENSP00000418342  

    SEC62 Human Recombinant Protein Products:

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    Novus Biologicals SEC62 Lysate
    Browse Sino Biological Recombinant Proteins
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    Browse Proteins at Cloud-Clone Corp.

    SEC62 Antibody Products:

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    Abcam antibodies for SEC62
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SEC62
    LSBio Antibodies in human, mouse, rat for SEC62

    SEC62 Assay Products:

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    GenScript Custom Assay Services for SEC62
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004728 Sec62

    Graphical View of Domain Structure for InterPro Entry Q99442

    ProtoNet protein and cluster: Q99442

    UniProtKB/Swiss-Prot: SEC62_HUMAN, Q99442
    Similarity: Belongs to the SEC62 family


    SEC62 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEC62_HUMAN, Q99442
    Function: Required for preprotein translocation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9020021
    GO:0005524ATP binding ----
    GO:0008565protein transporter activity IEA--
    GO:0042626ATPase activity, coupled to transmembrane movement of substances ----
         
    SEC62 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SEC62:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC62
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC62

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC62
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC62

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC62:
    hsa-mir-30a-5p (MIRT005126), hsa-mir-1 (MIRT023739)

    Block miRNA regulation of human, mouse, rat SEC62 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEC62 (see all 129):
    hsa-miR-4305 hsa-miR-134 hsa-miR-3653 hsa-miR-3116 hsa-miR-525-3p hsa-miR-520b hsa-miR-186* hsa-miR-519e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SEC62

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC62

    Clone
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    OriGene clones in human, mouse for SEC62 (see all 6)
    OriGene ORF clones in mouse, rat for SEC62
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    GenScript: all cDNA clones in your preferred vector: SEC62 (NM_003262)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC62
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC62

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SEC62 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC62


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEC62_HUMAN, Q99442: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytoskeleton4
    plasma membrane3
    nucleus2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9020021
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005791rough endoplasmic reticulum ISS--
    GO:0016020membrane IDA--
    GO:0016021integral component of membrane IEA--

    SEC62 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEC62 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    2Protein export
    Protein export

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for SEC62):
        Protein export
    Protein processing in endoplasmic reticulum


    SEC62 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SEC62: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SEC62

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC62 (Q994422, 3 ENSP000003376884) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CICQ96RK02, 3, ENSP000001607404MINT-2863613 I2D: score=3 STRING: ENSP00000160740
    SEC63Q9UGP83, ENSP000003579984I2D: score=2 STRING: ENSP00000357998
    GRB2P629933I2D: score=2 
    PCBD1P614573I2D: score=1 
    ZNF24P170283I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006613cotranslational protein targeting to membrane TAS9020021
    GO:0006620posttranslational protein targeting to membrane IMP--
    GO:0006810transport ----
    GO:0015031protein transport ----
    GO:0055085transmembrane transport ----

    SEC62 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC62



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEC62 gene: 
    NM_003262.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461933 ENST00000337002(uc003fgg.3 uc003fgh.3) ENST00000460513
    ENST00000480708 ENST00000487736 ENST00000469515 ENST00000481435 ENST00000497277
    ENST00000469890 ENST00000470355
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEC62 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEC62 (see all 129):
    hsa-miR-4305 hsa-miR-134 hsa-miR-3653 hsa-miR-3116 hsa-miR-525-3p hsa-miR-520b hsa-miR-186* hsa-miR-519e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEC62
    Predesigned siRNA for gene silencing in human, mouse, rat SEC62
    Clone
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    OriGene clones in human, mouse for SEC62 (see all 6)
    OriGene ORF clones in mouse, rat for SEC62
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC62 (NM_003262)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC62
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC62
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEC62
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC62
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC62
      QuantiTect SYBR Green Assays in human, mouse, rat SEC62
      QuantiFast Probe-based Assays in human, mouse, rat SEC62

    Selected AceView cDNA sequences (see all 566):

    BX497178 AA342774 AA918741 BM127078 AA450205 AW058545 AI215923 AA921678 
    F25954 CB134086 U93239 AU130253 BU608615 BU164780 AI435560 AK025548 
    AI632792 AI537279 AI279188 CA446325 H95986 N74523 AI421131 AI090964 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SEC62    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                            
    SP2:                                                            


    ECgene alternative splicing isoforms for SEC62

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEC62 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEC62 Expression
    About this image


    SEC62 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    SEC62 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC62 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SEC62: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEC62
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC62
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC62
    QuantiTect SYBR Green Assays in human, mouse, rat SEC62
    QuantiFast Probe-based Assays in human, mouse, rat SEC62
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC62

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC62 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec621 , 5 SEC62 homolog (S. cerevisiae)1, 5 90.79(n)1
    92.71(a)1
      3 (14.29 cM)5
    692761  NM_027016.21  NP_081292.11 
     307928765 
    chicken
    (Gallus gallus)
    Aves SEC621 SEC62 homolog (S. cerevisiae) 82.45(n)
    90.93(a)
      424993  NM_001012602.1  NP_001012620.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC626
    SEC62 homolog (S. cerevisiae)
    85(a)
    1 ↔ 1
    3(7851801-7866557)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237492 Xenopus laevis transcribed sequence with moderate similarity more 82.22(n)    BJ069499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sec621 SEC62 homolog (S. cerevisiae) 71.91(n)
    76.96(a)
      563660  NM_001025530.1  NP_001020701.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trp16
    Translocation protein 1
    34(a)
    1 ↔ 1
    2L(10009386-10013170)
    worm
    (Caenorhabditis elegans)
    Secernentea C18E9.26
    Protein C18E9.2, isoform a (C18E9.2) mRNA, complet...
    38(a)
    1 ↔ 1
    II(8965053-8966919) WBGene00007683
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC62(YPL094C)4 Essential subunit of Sec63 complex (Sec63p, Sec62p, more   --   16(370663-369839) 856011  NP_015231.2 


    ENSEMBL Gene Tree for SEC62 (if available)
    TreeFam Gene Tree for SEC62 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEC62 gene
    1 SIMAP similar gene for SEC62 using alignment to 6 protein entries:     SEC62_HUMAN (see all proteins):
    TLOC1

    SEC62 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEC62 (see all 602)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730439271,2
    C,F--169686837(+) TAATGG/AAAAGT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs345923751,2
    C--169687034(+) AAAAA-/AGTAGC 1 -- int10--------
    rs1410140211,2
    C--169687044(+) AAAAA-/GTAGCT 1 -- int10--------
    rs793037791,2
    C,F--169687227(+) GCTGCA/GTAGTA 1 -- int11Minor allele frequency- G:0.09WA 118
    rs1809708751,2
    --169687236(+) TAGAAA/GTTGAT 1 -- int10--------
    rs172894941,2
    C,F--169687277(+) TTTAAA/GAGGAT 1 -- int13Minor allele frequency- G:0.02NA 142
    rs113037901,2
    C--169687304(+) GAAGC-/CTTTTT 1 -- int10--------
    rs2001968921,2
    --169687306(+) AAGCC-/TTTTTC 1 -- int10--------
    rs781367981,2
    C,F--169687354(+) CTACAG/ACTGAC 1 -- int11Minor allele frequency- A:0.03EA 120
    rs730439281,2
    C--169687379(+) ACCCTC/TGTTTT 1 -- int13Minor allele frequency- T:0.06WA EA 240

    HapMap Linkage Disequilibrium report for SEC62 (169684423 - 169716161 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEC62:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2494675CNV Insertion19546169
    esv270037CNV Insertion20981092
    nsv877976CNV Gain21882294
    nsv7356OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC62
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC62

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602173    OMIM disorders: --

    8 diseases for SEC62:    
    About MalaCards
    polycystic liver disease    liver disease    ataxia    hepatocellular carcinoma
    prostate cancer    lung cancer    prostatitis    malaria


    SEC62 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEC62

    Export disorders for SEC62 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEC62 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with SEC62)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp-1). (PubMed id 9020021)1, 2, 3, 9 Daimon M.... Sasaki H. (Biochem. Biophys. Res. Commun. 1997)
    2. Mammalian Sec61 is associated with Sec62 and Sec63. (PubMed id 10799540)1, 2, 3 Meyer H.-A....Hartmann E. (J. Biol. Chem. 2000)
    3. Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene. (PubMed id 10683767)1, 2, 9 Daimon M.... Kato T. (IUBMB Life 1999)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. (PubMed id 23764425)1 Hagerstrand D....Hahn W.C. (Cancer Discov. 2013)
    7. CK2 phosphorylation of human Sec63 regulates its interaction with Sec62. (PubMed id 23287549)1 Ampofo E....Montenarh M. (Biochim. Biophys. Acta 2013)
    8. Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells. (PubMed id 24304694)1 Linxweiler M....Greiner M. (BMC Cancer 2013)
    9. Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation. (PubMed id 22648169)1 Lakkaraju A.K....Strub K. (Mol. Biol. Cell 2012)
    10. Identification of cyclin B1 and Sec62 as biomarkers for recurrence in patients with HBV-related hepatocellular carcinoma after surgical resection. (PubMed id 22682366)1 Weng L....Ling C. (Mol. Cancer 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7095 HGNC: 11846 AceView: TLOC1 Ensembl:ENSG00000008952 euGenes: HUgn7095
    ECgene: SEC62 Kegg: 7095 H-InvDB: SEC62

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEC62 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for SEC62 gene:
    Search GeneIP for patents involving SEC62

    GeneCards and IP:
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