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Aliases for SEC61G Gene

Aliases for SEC61G Gene

  • Sec61 Translocon Gamma Subunit 2 3 5
  • Sec61 Gamma Subunit 2 3
  • Protein Transport Protein SEC61 Gamma Subunit 3
  • SSS1 3

External Ids for SEC61G Gene

Previous GeneCards Identifiers for SEC61G Gene

  • GC07M054284
  • GC07M054527
  • GC07M054561
  • GC07M054594
  • GC07M054787

Summaries for SEC61G Gene

Entrez Gene Summary for SEC61G Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC61G Gene

SEC61G (Sec61 Translocon Gamma Subunit) is a Protein Coding gene. Among its related pathways are Protein export and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include protein transporter activity and P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for SEC61G Gene

  • Necessary for protein translocation in the endoplasmic reticulum.

Gene Wiki entry for SEC61G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61G Gene

Genomics for SEC61G Gene

Regulatory Elements for SEC61G Gene

Enhancers for SEC61G Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEC61G on UCSC Golden Path with GeneCards custom track

Promoters for SEC61G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC61G on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC61G Gene

54,752,247 bp from pter
54,759,974 bp from pter
7,728 bases
Minus strand

Genomic View for SEC61G Gene

Genes around SEC61G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61G Gene

Proteins for SEC61G Gene

  • Protein details for SEC61G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein transport protein Sec61 subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B2R4J0
    • P38384
    • Q6IB25

    Protein attributes for SEC61G Gene

    68 amino acids
    Molecular mass:
    7741 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

neXtProt entry for SEC61G Gene

Proteomics data for SEC61G Gene at MOPED

Post-translational modifications for SEC61G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC61G Gene

No data available for DME Specific Peptides for SEC61G Gene

Domains & Families for SEC61G Gene

Suggested Antigen Peptide Sequences for SEC61G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SecE/SEC61-gamma family.
  • Belongs to the SecE/SEC61-gamma family.
genes like me logo Genes that share domains with SEC61G: view

No data available for Gene Families for SEC61G Gene

Function for SEC61G Gene

Molecular function for SEC61G Gene

UniProtKB/Swiss-Prot Function:
Necessary for protein translocation in the endoplasmic reticulum.
genes like me logo Genes that share phenotypes with SEC61G: view

Animal Model Products

miRNA for SEC61G Gene

miRTarBase miRNAs that target SEC61G

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61G Gene

Localization for SEC61G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61G Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SEC61G Gene COMPARTMENTS Subcellular localization image for SEC61G gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
nucleus 2
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC61G: view

Pathways & Interactions for SEC61G Gene

genes like me logo Genes that share pathways with SEC61G: view

Gene Ontology (GO) - Biological Process for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0006886 intracellular protein transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with SEC61G: view

No data available for SIGNOR curated interactions for SEC61G Gene

Drugs & Compounds for SEC61G Gene

No Compound Related Data Available

Transcripts for SEC61G Gene

Unigene Clusters for SEC61G Gene

Sec61 gamma subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61G Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for SEC61G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC61G Gene

mRNA expression in normal human tissues for SEC61G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61G Gene

This gene is overexpressed in Bone (16.0) and Hair follicle (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC61G Gene

SOURCE GeneReport for Unigene cluster for SEC61G Gene Hs.488282

genes like me logo Genes that share expression patterns with SEC61G: view

Protein tissue co-expression partners for SEC61G Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC61G Gene

Orthologs for SEC61G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEC61G 35
  • 96.57 (n)
  • 100 (a)
SEC61G 36
  • 100 (a)
(Canis familiaris)
Mammalia SEC61G 35
  • 96.57 (n)
  • 100 (a)
SEC61G 36
  • 100 (a)
(Mus musculus)
Mammalia LOC102637269 35
  • 92.65 (n)
  • 100 (a)
Sec61g 16
Sec61g 36
  • 68 (a)
(Pan troglodytes)
Mammalia SEC61G 35
  • 100 (n)
  • 100 (a)
SEC61G 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC499136 35
  • 88.89 (n)
  • 93.33 (a)
(Monodelphis domestica)
Mammalia SEC61G 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia SEC61G 36
  • 100 (a)
(Gallus gallus)
Aves SEC61G 35
  • 88.73 (n)
  • 100 (a)
SEC61G 36
  • 100 (a)
(Anolis carolinensis)
Reptilia SEC61G 36
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec61g 35
  • 82.35 (n)
  • 98.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia sec61g-A 35
(Danio rerio)
Actinopterygii hmzehn1231 35
sec61g 35
  • 82.35 (n)
  • 100 (a)
sec61g 36
  • 100 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10075 35
fruit fly
(Drosophila melanogaster)
Insecta CG8860 35
  • 70.15 (n)
  • 86.57 (a)
CG13426 36
  • 35 (a)
CG8860 36
  • 82 (a)
Sec61gamma 36
  • 81 (a)
(Caenorhabditis elegans)
Secernentea emo-1 35
  • 74.51 (n)
  • 85.29 (a)
emo-1 36
  • 82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSS1 36
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24920 35
  • 65.69 (n)
  • 72.06 (a)
(Oryza sativa)
Liliopsida Os02g0178400 35
  • 59.31 (n)
  • 72.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15317 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3850 36
  • 87 (a)
Species with no ortholog for SEC61G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC61G Gene

Gene Tree for SEC61G (if available)
Gene Tree for SEC61G (if available)

Paralogs for SEC61G Gene

No data available for Paralogs for SEC61G Gene

Variants for SEC61G Gene

Sequence variations from dbSNP and Humsavar for SEC61G Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6952793 -- 54,752,493(+) ATGCA(A/G)TATGC intron-variant
rs1802301 -- 54,752,298(-) TTTCC(C/T)TTCAA utr-variant-3-prime
rs1919828 -- 54,754,606(-) GATTT(C/T)TGAAG intron-variant
rs17172381 -- 54,752,703(+) ACACA(A/G)CAAAA intron-variant
rs7782367 -- 54,753,888(+) AAGTT(C/T)TCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC61G Gene

Variant ID Type Subtype PubMed ID
esv2734425 CNV Deletion 23290073

Variation tolerance for SEC61G Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SEC61G Gene

Disorders for SEC61G Gene

Relevant External Links for SEC61G

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC61G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC61G Gene

Publications for SEC61G Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PMID: 10212142) Greenfield J.J. … High S. (J. Cell. Sci. 1999) 2 3
  3. Evolutionary conservation of components of the protein translocation complex. (PMID: 8107851) Hartmann E. … Rapoport T.A. (Nature 1994) 2 3
  4. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3
  5. An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. (PMID: 24497544) Mackinnon A.L. … Taunton J. (Elife 2014) 3

Products for SEC61G Gene

Sources for SEC61G Gene