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Aliases for SEC61G Gene

Aliases for SEC61G Gene

  • Sec61 Translocon Gamma Subunit 2 3 5
  • Sec61 Gamma Subunit 2 3
  • Protein Transport Protein SEC61 Gamma Subunit 3
  • Protein Transport Protein Sec61 Subunit Gamma 3
  • SSS1 3

External Ids for SEC61G Gene

Previous GeneCards Identifiers for SEC61G Gene

  • GC07M054284
  • GC07M054527
  • GC07M054561
  • GC07M054594
  • GC07M054787

Summaries for SEC61G Gene

Entrez Gene Summary for SEC61G Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC61G Gene

SEC61G (Sec61 Translocon Gamma Subunit) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein transporter activity and P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for SEC61G Gene

  • Necessary for protein translocation in the endoplasmic reticulum.

Gene Wiki entry for SEC61G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61G Gene

Genomics for SEC61G Gene

Regulatory Elements for SEC61G Gene

Enhancers for SEC61G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G054773 1.2 Ensembl ENCODE 49.9 -14.3 -14261 1.4 ELF3 PKNOX1 FOXA2 ATF1 CBX3 RB1 ARID4B SIN3A ZNF2 ZNF48 SEC61G LOC100996654 GC07P054865
GH07G054757 1 ENCODE 50.3 +1.0 982 2.9 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS PAF1 SP3 SEC61G LOC100996654 GC07P054734
GH07G054809 0.9 Ensembl ENCODE 37.3 -51.3 -51349 2.7 ELF3 CTCF NR2F1 BHLHE40 CEBPB JUNB EP300 RAD21 TEAD3 JUND SEC61G LOC100996654 GC07P054865
GH07G055253 1.4 FANTOM5 ENCODE 10.6 -495.0 -495004 2.3 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZBTB7B GLIS2 ZNF143 ZNF207 ZNF263 LOC100130121 LOC100996654 SEC61G EGFR PIR38213
GH07G054813 0.4 ENCODE 36.1 -53.6 -53649 0.2 YY1 SEC61G LOC100996654 GC07P054865
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC61G on UCSC Golden Path with GeneCards custom track

Promoters for SEC61G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212578 974 2401 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS PAF1 SP3

Genomic Location for SEC61G Gene

54,752,247 bp from pter
54,759,974 bp from pter
7,728 bases
Minus strand

Genomic View for SEC61G Gene

Genes around SEC61G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61G Gene

Proteins for SEC61G Gene

  • Protein details for SEC61G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein transport protein Sec61 subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B2R4J0
    • P38384
    • Q6IB25

    Protein attributes for SEC61G Gene

    68 amino acids
    Molecular mass:
    7741 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

neXtProt entry for SEC61G Gene

Post-translational modifications for SEC61G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC61G Gene

No data available for DME Specific Peptides for SEC61G Gene

Domains & Families for SEC61G Gene

Suggested Antigen Peptide Sequences for SEC61G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SecE/SEC61-gamma family.
  • Belongs to the SecE/SEC61-gamma family.
genes like me logo Genes that share domains with SEC61G: view

No data available for Gene Families for SEC61G Gene

Function for SEC61G Gene

Molecular function for SEC61G Gene

UniProtKB/Swiss-Prot Function:
Necessary for protein translocation in the endoplasmic reticulum.

Gene Ontology (GO) - Molecular Function for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008565 protein transporter activity ISS --
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SEC61G: view
genes like me logo Genes that share phenotypes with SEC61G: view

Animal Model Products

CRISPR Products

miRNA for SEC61G Gene

miRTarBase miRNAs that target SEC61G

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61G Gene

Localization for SEC61G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61G Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC61G gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
genes like me logo Genes that share ontologies with SEC61G: view

Pathways & Interactions for SEC61G Gene

genes like me logo Genes that share pathways with SEC61G: view

Gene Ontology (GO) - Biological Process for SEC61G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with SEC61G: view

No data available for SIGNOR curated interactions for SEC61G Gene

Drugs & Compounds for SEC61G Gene

No Compound Related Data Available

Transcripts for SEC61G Gene

Unigene Clusters for SEC61G Gene

Sec61 gamma subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61G Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for SEC61G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC61G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC61G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61G Gene

This gene is overexpressed in Bone (16.0) and Hair follicle (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC61G Gene

Protein tissue co-expression partners for SEC61G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC61G Gene:


SOURCE GeneReport for Unigene cluster for SEC61G Gene:


Evidence on tissue expression from TISSUES for SEC61G Gene

  • Lung(4.4)
  • Nervous system(4.4)
  • Skin(4.3)
  • Blood(4.2)
  • Adrenal gland(2)
  • Intestine(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with SEC61G: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC61G Gene

Orthologs for SEC61G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC61G 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia SEC61G 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia SEC61G 35
  • 100 (a)
(Bos Taurus)
Mammalia SEC61G 34 35
  • 96.57 (n)
(Canis familiaris)
Mammalia SEC61G 34 35
  • 96.57 (n)
(Mus musculus)
Mammalia LOC102637269 34
  • 92.65 (n)
Sec61g 16 35
  • 68 (a)
(Rattus norvegicus)
Mammalia LOC499136 34
  • 88.89 (n)
(Gallus gallus)
Aves SEC61G 34 35
  • 88.73 (n)
(Anolis carolinensis)
Reptilia SEC61G 35
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec61g 34
  • 82.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia sec61g-A 34
(Danio rerio)
Actinopterygii sec61g 34 35
  • 82.35 (n)
hmzehn1231 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10075 34
fruit fly
(Drosophila melanogaster)
Insecta Sec61gamma 35
  • 81 (a)
CG8860 34 35
  • 70.15 (n)
CG13426 35
  • 35 (a)
(Caenorhabditis elegans)
Secernentea emo-1 34 35
  • 74.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSS1 35
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24920 34
  • 65.69 (n)
(Oryza sativa)
Liliopsida Os02g0178400 34
  • 59.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3850 35
  • 87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15317 34
Species where no ortholog for SEC61G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC61G Gene

Gene Tree for SEC61G (if available)
Gene Tree for SEC61G (if available)

Paralogs for SEC61G Gene

No data available for Paralogs for SEC61G Gene

Variants for SEC61G Gene

Sequence variations from dbSNP and Humsavar for SEC61G Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000155095 -- 54,756,566(+) CAGAA(C/T)TGCTT intron-variant
rs1000943817 -- 54,756,740(+) CTGAC(G/T)TGGTT intron-variant
rs1001203345 -- 54,759,404(+) AGCGT(C/T)ATCCC nc-transcript-variant, upstream-variant-2KB
rs1001376226 -- 54,756,957(+) TATAT(-/AC)TATAT intron-variant
rs1001700578 -- 54,754,002(+) AAGGG(A/G)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC61G Gene

Variant ID Type Subtype PubMed ID
esv2734425 CNV deletion 23290073
esv2761332 CNV gain 21179565
nsv1024361 CNV gain 25217958
nsv1030676 CNV gain 25217958
nsv607029 CNV gain 21841781

Variation tolerance for SEC61G Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC61G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC61G Gene

Disorders for SEC61G Gene

Relevant External Links for SEC61G

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC61G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC61G Gene

Publications for SEC61G Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  3. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PMID: 10212142) Greenfield J.J. … High S. (J. Cell. Sci. 1999) 2 3 64
  4. Evolutionary conservation of components of the protein translocation complex. (PMID: 8107851) Hartmann E. … Rapoport T.A. (Nature 1994) 2 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for SEC61G Gene

Sources for SEC61G Gene

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