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Aliases for SEC61B Gene

Aliases for SEC61B Gene

  • Sec61 Translocon Beta Subunit 2 3 5
  • Sec61 Beta Subunit 2

External Ids for SEC61B Gene

Previous GeneCards Identifiers for SEC61B Gene

  • GC09P092784
  • GC09P093728
  • GC00U912984
  • GC09P097364
  • GC09P099064
  • GC09P101024
  • GC09P101984
  • GC09P071583

Summaries for SEC61B Gene

Entrez Gene Summary for SEC61B Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC61B Gene

SEC61B (Sec61 Translocon Beta Subunit) is a Protein Coding gene. Among its related pathways are Protein export and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include poly(A) RNA binding and epidermal growth factor binding.

UniProtKB/Swiss-Prot for SEC61B Gene

  • Necessary for protein translocation in the endoplasmic reticulum.

Gene Wiki entry for SEC61B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61B Gene

Genomics for SEC61B Gene

Regulatory Elements for SEC61B Gene

Enhancers for SEC61B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEC61B on UCSC Golden Path with GeneCards custom track

Promoters for SEC61B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC61B on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC61B Gene

99,222,064 bp from pter
99,230,619 bp from pter
8,556 bases
Plus strand

Genomic View for SEC61B Gene

Genes around SEC61B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61B Gene

Proteins for SEC61B Gene

  • Protein details for SEC61B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein transport protein Sec61 subunit beta
    Protein Accession:
    Secondary Accessions:
    • P38390
    • P38391
    • Q6IBC1

    Protein attributes for SEC61B Gene

    96 amino acids
    Molecular mass:
    9974 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.

neXtProt entry for SEC61B Gene

Proteomics data for SEC61B Gene at MOPED

Post-translational modifications for SEC61B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC61B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SEC61B (SEC61B)

No data available for DME Specific Peptides for SEC61B Gene

Domains & Families for SEC61B Gene

Protein Domains for SEC61B Gene


Suggested Antigen Peptide Sequences for SEC61B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC61-beta family.
  • Belongs to the SEC61-beta family.
genes like me logo Genes that share domains with SEC61B: view

No data available for Gene Families for SEC61B Gene

Function for SEC61B Gene

Molecular function for SEC61B Gene

UniProtKB/Swiss-Prot Function:
Necessary for protein translocation in the endoplasmic reticulum.
genes like me logo Genes that share phenotypes with SEC61B: view

Animal Model Products

miRNA for SEC61B Gene

miRTarBase miRNAs that target SEC61B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61B Gene

Localization for SEC61B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61B Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SEC61B Gene COMPARTMENTS Subcellular localization image for SEC61B gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
mitochondrion 2
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SEC61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005784 Sec61 translocon complex IEA --
GO:0005829 cytosol TAS --
GO:0016021 integral component of membrane NAS 8107851
genes like me logo Genes that share ontologies with SEC61B: view

Pathways & Interactions for SEC61B Gene

genes like me logo Genes that share pathways with SEC61B: view

Gene Ontology (GO) - Biological Process for SEC61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 17215517
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0006886 intracellular protein transport IEA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IDA 8945469
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
genes like me logo Genes that share ontologies with SEC61B: view

No data available for SIGNOR curated interactions for SEC61B Gene

Drugs & Compounds for SEC61B Gene

No Compound Related Data Available

Transcripts for SEC61B Gene

mRNA/cDNA for SEC61B Gene

Unigene Clusters for SEC61B Gene

Sec61 beta subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - - - - - -
SP3: - - -
SP4: - -

Relevant External Links for SEC61B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC61B Gene

mRNA expression in normal human tissues for SEC61B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61B Gene

This gene is overexpressed in Nasal epithelium (18.1) and Bone (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC61B Gene

SOURCE GeneReport for Unigene cluster for SEC61B Gene Hs.191887

genes like me logo Genes that share expression patterns with SEC61B: view

Protein tissue co-expression partners for SEC61B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC61B Gene

Orthologs for SEC61B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEC61B 35
  • 93.4 (n)
  • 98.96 (a)
SEC61B 36
  • 99 (a)
(Canis familiaris)
Mammalia SEC61B 35
  • 93.75 (n)
  • 100 (a)
SEC61B 36
  • 100 (a)
(Mus musculus)
Mammalia Sec61b 35
  • 88.89 (n)
  • 98.96 (a)
Sec61b 16
Sec61b 36
  • 99 (a)
(Pan troglodytes)
Mammalia SEC61B 35
  • 100 (n)
  • 100 (a)
SEC61B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sec61b 35
  • 89.93 (n)
  • 98.96 (a)
(Monodelphis domestica)
Mammalia SEC61B 36
  • 96 (a)
(Gallus gallus)
Aves SEC61B 35
  • 81.6 (n)
  • 93.75 (a)
SEC61B 36
  • 94 (a)
(Anolis carolinensis)
Reptilia SEC61B 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec61b 35
  • 73.61 (n)
  • 90.62 (a)
Str.1470 35
African clawed frog
(Xenopus laevis)
Amphibia sec61beta-prov 35
(Danio rerio)
Actinopterygii Dr.28987 35
sec61b 35
  • 72.92 (n)
  • 81.25 (a)
sec61b 36
  • 80 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8291 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011504 35
  • 62.46 (n)
  • 70.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sec61beta 35
  • 66.67 (n)
  • 71.58 (a)
Sec61beta 36
  • 68 (a)
(Caenorhabditis elegans)
Secernentea Y38F2AR.9 36
  • 60 (a)
(Triticum aestivum)
Liliopsida Ta.11126 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for SEC61B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SEC61B Gene

Gene Tree for SEC61B (if available)
Gene Tree for SEC61B (if available)

Paralogs for SEC61B Gene Pseudogenes for SEC61B Gene

genes like me logo Genes that share paralogs with SEC61B: view

No data available for Paralogs for SEC61B Gene

Variants for SEC61B Gene

Sequence variations from dbSNP and Humsavar for SEC61B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs701374 -- 99,227,215(-) aattt(C/T)tgctc intron-variant
rs7847632 -- 99,227,415(+) AAATA(C/T)ATCTT intron-variant
rs1648649 -- 99,227,263(-) tttga(A/G)aagga intron-variant
rs1648650 -- 99,227,261(-) TGAGA(A/T)GGAGT intron-variant
rs1755667 -- 99,227,173(+) aggca(A/G)aagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC61B Gene

Variant ID Type Subtype PubMed ID
nsv831666 CNV Gain 17160897

Variation tolerance for SEC61B Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SEC61B Gene

Disorders for SEC61B Gene

Relevant External Links for SEC61B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC61B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC61B Gene

Publications for SEC61B Gene

  1. Evolutionary conservation of components of the protein translocation complex. (PMID: 8107851) Hartmann E. … Rapoport T.A. (Nature 1994) 2 3 4 67
  2. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PMID: 10212142) Greenfield J.J. … High S. (J. Cell. Sci. 1999) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SEC61B Gene

Sources for SEC61B Gene