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SEC61B Gene

protein-coding   GIFtS: 55
GCID: GC09P101984

Sec61 Beta Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sec61 Beta Subunit1 2
Protein Translocation Complex Beta2
Protein Transport Protein SEC61 Beta Subunit2
Protein Transport Protein Sec61 Subunit Beta2
Sec61 Complex, Beta Subunit2

External Ids:    HGNC: 169931   Entrez Gene: 109522   Ensembl: ENSG000001068037   OMIM: 6092145   UniProtKB: P604683   

Export aliases for SEC61B gene to outside databases

Previous GC identifers: GC09P092784 GC09P093728 GC00U912984 GC09P097364 GC09P099064 GC09P101024 GC09P071583


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEC61B Gene:
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum
(ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across
and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma.
This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment,
suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated
sites for this transcript. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEC61B Gene:
SEC61B (Sec61 beta subunit) is a protein-coding gene. Diseases associated with SEC61B include cholera, and colon adenocarcinoma. GO annotations related to this gene include epidermal growth factor binding.

UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468
Function: Necessary for protein translocation in the endoplasmic reticulum

Gene Wiki entry for SEC61B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC61B gene promoter:
         GR   Bach1   E2F-4   E2F-3a   E2F-5   E2F-2   E47   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC61B promoter sequence
   Search Chromatin IP Primers for SEC61B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC61B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.32-q31.3   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.32-q31.3

SEC61B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC61B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P101984:  view genomic region     (about GC identifiers)

Start:
101,984,346 bp from pter      End:
101,992,901 bp from pter
Size:
8,556 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468 (See protein sequence)
Recommended Name: Protein transport protein Sec61 subunit beta  
Size: 96 amino acids; 9974 Da
Subunit: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of
SEC61, SEC62 and SEC63. Interacts with SEC62
Secondary accessions: P38390 P38391 Q6IBC1

Explore the universe of human proteins at neXtProt for SEC61B: NX_P60468

Explore proteomics data for SEC61B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SEC61B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006799.1  
    ENSEMBL proteins: 
     ENSP00000474122   ENSP00000223641  
    Reactome Protein details: P60468

    SEC61B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR016482 SecG/Sec61-beta/Sbh1

    Graphical View of Domain Structure for InterPro Entry P60468

    ProtoNet protein and cluster: P60468

    1 Blocks protein domain: IPB005609 Sec61beta

    UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468
    Similarity: Belongs to the SEC61-beta family


    SEC61B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC61B_HUMAN, P60468
    Function: Necessary for protein translocation in the endoplasmic reticulum

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18555783
    GO:0043022ribosome binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0048408epidermal growth factor binding IPI19602593
         
    SEC61B for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    hsa-mir-324-5p (MIRT043126), hsa-mir-133a-3p (MIRT021708)

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    2 qRT-PCR Assays for microRNAs that regulate SEC61B:
    hsa-miR-133a hsa-miR-133b
    SwitchGear 3'UTR luciferase reporter plasmidSEC61B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC61B_HUMAN, P60468: Endoplasmic reticulum membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion2
    cytosol1
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0016020membrane IDA--
    GO:0016021integral component of membrane NAS8107851
    GO:0031205endoplasmic reticulum Sec complex ISS--

    SEC61B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEC61B About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.80
    Immune response Antigen presentation by MHC class I0.68
    Antigen processing-Cross presentation0.80
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    3Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    4Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59
    5Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SEC61B
        Cholera Infection

    3 GeneGo (Thomson Reuters) Pathways for SEC61B
        Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR


    2 Reactome Pathways for SEC61B
        SRP-dependent cotranslational protein targeting to membrane
    ER-Phagosome pathway


    4 Kegg Pathways  (Kegg details for SEC61B):
        Protein export
    Protein processing in endoplasmic reticulum
    Phagosome
    Vibrio cholerae infection


    SEC61B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC61B
    Interactions:

        Search GeneGlobe Interaction Network for SEC61B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC61B (P604681, 2, 3 ENSP000002236414) via UniProtKB, MINT, STRING, and/or I2D (see all 219)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSR1P433072, 3, ENSP000002447634MINT-4546723 I2D: score=1 STRING: ENSP00000244763
    BAG6P463793, ENSP000003651314I2D: score=1 STRING: ENSP00000365131
    ENSG00000096155P463793I2D: score=1 
    ENSG00000227761P463793I2D: score=1 
    ENSG00000228760P463793I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IMP17215517
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0006412translation TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--

    SEC61B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC61B (SC61B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEC61B gene: 
    NM_006808.2  

    Unigene Cluster for SEC61B:

    Sec61 beta subunit
    Hs.191887  [show with all ESTs]
    Unigene Representative Sequence: BG573843
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498603 ENST00000223641(uc004azh.3) ENST00000481573
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SEC61B:
    hsa-miR-133a hsa-miR-133b
    SwitchGear 3'UTR luciferase reporter plasmidSEC61B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SEC61B
      QuantiFast Probe-based Assays in human, mouse, rat SEC61B

    Additional mRNA sequence: 

    AJ293399.1 AK223384.1 BC001734.1 CR456883.1 CR542159.1 L25085.1 

    9 DOTS entries:

    DT.115567  DT.204367  DT.86855687  DT.75125416  DT.95110708  DT.91756687  DT.95194876  DT.121166168 
    DT.40228340 

    Selected AceView cDNA sequences (see all 221):

    BM849528 N93326 AI216090 BG032213 BM785224 BM353497 BM768855 BM764344 
    AA305690 BG029603 BQ084144 BU786380 AI281953 BF444920 NM_006808 BE790184 
    T87347 AI279456 BE327671 AI695014 BM769151 AI457886 BM045148 AA083469 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SEC61B    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                -                 -               
    SP2:        -     -     -           -     -           -               
    SP3:                                -     -           -               
    SP4:                                -     -                           
    SP5:                                                                  


    ECgene alternative splicing isoforms for SEC61B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEC61B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAAATTT
    SEC61B Expression
    About this image


    SEC61B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    SEC61B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC61B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191887
        Custom PCR Arrays for SEC61B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC61B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC61B gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec61b1 , 5 Sec61 beta subunit1, 5 88.89(n)1
    98.96(a)1
      4 (26.03 cM)5
    662121  NM_024171.21  NP_077133.11 
     474746585 
    chicken
    (Gallus gallus)
    Aves SEC61B1 Sec61 beta subunit 81.6(n)
    93.75(a)
      420997  XM_419082.3  XP_419082.3 
    lizard
    (Anolis carolinensis)
    Reptilia SEC61B6
    Sec61 beta subunit
    94(a)
    1 ↔ 1
    6(55622256-55625478)
    African clawed frog
    (Xenopus laevis)
    Amphibia sec61beta-prov2 protein translocation complex beta 75.26(n)    BC041270.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.289872 Transcribed sequence with moderate similarity to protein refNP_006799.1 (H.sapiens) protein translocation complex beta; protein transport protein SEC61 beta subunit [Homo sapiens] less 75.78(n)    AL917539.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sec61beta1 Sec61beta 66.67(n)
    71.58(a)
      46080  NM_143780.3  NP_652037.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y38F2AR.96
    Protein Y38F2AR.9 (Y38F2AR.9) mRNA, complete cds
    60(a)
    1 ↔ 1
    IV(2388194-2388675) WBGene00021427
    wheat
    (Triticum aestivum)
    Liliopsida Ta.111262 Triticum aestivum transcribed sequence with weak similarity to protein refNP_182033.1 (A.thaliana) putative transport protein SEC61 beta-subunit [Arabidopsis thaliana] less 74.39(n)    BF203025.1 


    ENSEMBL Gene Tree for SEC61B (if available)
    TreeFam Gene Tree for SEC61B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEC61B gene

    SEC61B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SEC61B
    PGOHUM00000242224


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEC61B (see all 145)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139162881,2
    C,F--101986257(+) CAAGTG/CATTTC 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1160057801,2
    F--101986291(+) CATGAC/TACAAT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1496597721,2
    C--101986495(+) ATTTCA/GCATCA 1 -- int10--------
    rs1145990671,2
    C,F--101986564(+) GTTCCC/TTGTCA 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1857223991,2
    --101986572(+) TCATTA/GGGATG 1 -- int10--------
    rs70361641,2
    C,F,A,H--101986627(+) TGAGTG/ACTGTC 1 -- int125Minor allele frequency- A:0.23NS EA NA WA 2764
    rs1894501651,2
    --101986664(+) TTTTCA/GTGCAG 1 -- int10--------
    rs1809689091,2
    --101986866(+) ACAAGC/TGAAAT 1 -- int10--------
    rs1448494961,2
    --101987019(+) CTTCTA/GGAATG 1 -- int10--------
    rs1485761431,2
    --101987020(+) TTCTAC/GAATGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SEC61B (101984346 - 101992901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SEC61B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831666CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC61B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609214    OMIM disorders: --

    7 diseases for SEC61B:    
    About MalaCards
    cholera    colon adenocarcinoma    cystic fibrosis    malaria
    colorectal cancer    adenocarcinoma    breast cancer


    SEC61B for disorders           About GeneDecksing


    Export disorders for SEC61B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEC61B gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with SEC61B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolutionary conservation of components of the protein translocation complex. (PubMed id 8107851)1, 2, 3 Hartmann E....Rapoport T.A. (Nature 1994)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Mammalian Sec61 is associated with Sec62 and Sec63. (PubMed id 10799540)1, 2 Meyer H.-A....Hartmann E. (J. Biol. Chem. 2000)
    6. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PubMed id 10212142)1, 3 Greenfield J.J. and High S. (J. Cell. Sci. 1999)
    7. OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation. (PubMed id 23606741)1 Dumax-Vorzet A....High S. (J. Cell. Sci. 2013)
    8. Genetics of callous-unemotional behavior in children. (PubMed id 23874384)1 Viding E....Plomin R. (PLoS ONE 2013)
    9. The association of BAG6 with SGTA and tail-anchored proteins. (PubMed id 23533635)1 Leznicki P....High S. (PLoS ONE 2013)
    10. SGTA antagonizes BAG6-mediated protein triage. (PubMed id 23129660)1 Leznicki P. and High S. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10952 HGNC: 16993 AceView: SEC61B Ensembl:ENSG00000106803 euGenes: HUgn10952
    ECgene: SEC61B Kegg: 10952 H-InvDB: SEC61B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEC61B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEC61B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEC61B gene:
    Search GeneIP for patents involving SEC61B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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