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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEC61B Gene

protein-coding GIFtS: 52
GCID: GC09P101984

Sec61 beta subunit

Explore 3 diseases affiliated with
SEC61B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sec61 Beta Subunit¹ ²
Protein Translocation Complex Beta²
Protein Transport Protein SEC61 Beta Subunit²
Protein Transport Protein Sec61 Subunit Beta²
Sec61 Complex, Beta Subunit²

External Ids:	HGNC: 16993¹	Entrez Gene: 10952²	Ensembl: ENSG00000106803⁷	OMIM: 609214⁵	UniProtKB: P60468³

Export aliases for SEC61B gene to outside databases

Previous GC identifers: GC09P092784 GC09P093728 GC00U912984 GC09P097364 GC09P099064 GC09P101024 GC09P071583

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC61B:

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER)

membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and

integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene

encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that

these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this

transcript. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468

Function: Necessary for protein translocation in the endoplasmic reticulum

Gene Wiki entry for SEC61B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEC61B gene promoter:
GR Bach1 E2F-4 E2F-3a E2F-5 E2F-2 E47 E2F E2F-1 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEC61B promoter sequence

Search SABiosciences Chromatin IP Primers for SEC61B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC61B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.32-q31.3 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.32-q31.3

SEC61B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC61B gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P101984: view genomic region (about GC identifiers)

Start:	101,984,346 bp from pter	End:	101,992,901 bp from pter
Size:	8,556 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468 (See protein sequence)

Recommended Name: Protein transport protein Sec61 subunit beta

Size: 96 amino acids; 9974 Da

Subunit: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of

SEC61, SEC62 and SEC63. Interacts with SEC62

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein

Secondary accessions: P38390 P38391 Q6IBC1

Explore the universe of human proteins at neXtProt for SEC61B: NX_P60468

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P60468

SEC61B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006799.1

ENSEMBL proteins:

ENSP00000223641

Reactome Protein details: P60468
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for SEC61B
	Novus Biologicals SEC61B Proteins Novus Biologicals SEC61B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	NAS	8107851
GO:0030670	phagocytic vesicle membrane	--	--
GO:0031205	endoplasmic reticulum Sec complex	ISS	--

SEC61B for ontologies About GeneDecksing

SEC61B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SEC61B
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	Novus Biologicals SEC61B Antibodies
	Search for Antibodies for SEC61B at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibody for SEC61B

Assay Products for SEC61B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SEC61B
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEC61B for domains About GeneDecksing

2 InterPro domains/families:

IPR005609 Sec61_beta

IPR016482 Sec61_beta_euk

Graphical View of Domain Structure for InterPro Entry P60468

ProtoNet protein and cluster: P60468

1 Blocks protein family: IPB005609 Sec61beta

UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468

Similarity: Belongs to the SEC61-beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468

Function: Necessary for protein translocation in the endoplasmic reticulum

miRNA Products:		OriGene 3'-UTR Clone: SEC61B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC61B
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC61B:
		hsa-miR-133a hsa-miR-133b
		SwitchGear 3'UTR luciferase reporter plasmid: SEC61B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC61B (see all 7) OriGene shRNA RFP: SEC61B OriGene siRNA: SEC61B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC61B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SEC61B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEC61B (NM_006808)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC61B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC61B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEC61B
		Search LifeMap BioReagents cell lines for SEC61B

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SEC61B

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18555783
GO:0048408	epidermal growth factor binding	IPI	19602593

SEC61B for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of degradation of wt-CFTR

Regulation of degradation of wt-CFTR

1.00

Regulation of degradation of deltaF508 CFTR in CF

0.59

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Immune response Antigen presentation by MHC class I

Immune response Antigen presentation by MHC class I

1.00

Immune response_Antigen presentation by MHC class I

0.92

Synthesis of PB1-F2

SRP-dependent cotranslational protein targeting to membrane

0.77

Translation

0.57

Ubiquitinated Orc1 is degraded by the proteasome

ER-Phagosome pathway

0.74

Antigen processing-Cross presentation

0.60

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SEC61B

Immune response Antigen presentation by MHC class I

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC61B

Cholera Infection

3 GeneGo (Thomson Reuters) Pathways for SEC61B

	Immune response Antigen presentation by MHC class I
	Regulation of degradation of deltaF508 CFTR in CF
	Regulation of degradation of wt-CFTR

5/9 Reactome Pathways for SEC61B (see all 9)

	Translation
	Antigen processing-Cross presentation
	SRP-dependent cotranslational protein targeting to membrane
	Adaptive Immune System
	ER-Phagosome pathway

4 Kegg Pathways (Kegg details for SEC61B):

	Protein export
	Protein processing in endoplasmic reticulum
	Phagosome
	Vibrio cholerae infection

SEC61B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEC61B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/147 Interacting proteins for SEC61B (P60468^{1, 2, 3} ENSP00000223641⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 147)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCAP31	P51572¹^,³, ENSP00000392330⁴	EBI-1788819,EBI-77683 I2D: score=1 STRING: ENSP00000392330
SSR1	P43307²^,³, ENSP00000244763⁴	MINT-4546723 I2D: score=1 STRING: ENSP00000244763
APOB	P04114³, ENSP00000233242⁴	I2D: score=2 STRING: ENSP00000233242
ARL6	Q9H0F7³, ENSP00000337722⁴	I2D: score=2 STRING: ENSP00000337722
TRAM1	Q15629³, ENSP00000262213⁴	I2D: score=2 STRING: ENSP00000262213

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IMP	17215517
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0006412	translation	TAS	--
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	--

SEC61B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEC61B
Search CenterWatch for drugs/clinical trials and news about SEC61B / SC61B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEC61B gene:

NM_006808.2

Unigene Cluster for SEC61B:

Sec61 beta subunit

Hs.191887 [show with all ESTs]

Unigene Representative Sequence: BG573843

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000498603 ENST00000223641(uc004azh.3) ENST00000481573

miRNA Products:		OriGene 3'-UTR Clone: SEC61B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC61B
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC61B:
		hsa-miR-133a hsa-miR-133b
		SwitchGear 3'UTR luciferase reporter plasmid: SEC61B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC61B (see all 7) OriGene shRNA RFP: SEC61B OriGene siRNA: SEC61B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC61B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEC61B (NM_006808)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC61B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC61B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC61B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEC61B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC61B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC61B

Additional cDNA sequence:

AJ293399.1 AK223384.1 BC001734.1 CR456883.1 CR542159.1 L25085.1

9 DOTS entries:

DT.115567 DT.204367 DT.86855687 DT.75125416 DT.95110708 DT.91756687 DT.95194876 DT.121166168

DT.40228340

24/221 AceView cDNA sequences (see all 221):

BF444920 BM768855 BU634312 AI912692 BM799831 AI281953 BM674319 BG032213

AI457230 BQ645681 BM785224 AI279456 BM353497 BU072902 BG257925 AA083469

BF726545 BC001734 AA305690 BQ918672 CR542159 BE327671 CA941830 BM045148

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SEC61B About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b
SP1:											-						-
SP2:			-		-		-				-		-				-
SP3:											-		-				-
SP4:											-		-
SP5:

ECgene alternative splicing isoforms for SEC61B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEC61B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGAAATTT

About this image
See SEC61B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC61B

SOURCE GeneReport for Unigene cluster: Hs.191887

SABiosciences Custom PCR Arrays for SEC61B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC61B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC61B

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SEC61B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61B gene from 9/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sec61b^{1 , 5}	Sec61 beta subunit^{1, 5}	88.89(n)¹ 98.96(a)¹		4 (26.03 cM)⁵ 66212¹ NM_024171.2¹ NP_077133.1¹ 47474658⁵
chicken (Gallus gallus)	Aves	SEC61B⁶	Uncharacterized protein	93(a)	1 ↔ 1	2(92017381-92021188)
lizard (Anolis carolinensis)	Reptilia	SEC61B⁶	--	94(a)	1 ↔ 1	6(55622256-55625478)
African clawed frog (Xenopus laevis)	Amphibia	sec61beta-prov²	protein translocation complex beta	75.26(n)		BC041270.1
zebrafish (Danio rerio)	Actinopterygii	Dr.28987²	Transcribed sequence with moderate similarity to protein refNP_006799.1 (H.sapiens) protein translocation complex beta; protein transport protein SEC61 beta subunit [Homo sapiens] less	75.78(n)		AL917539.1
fruit fly (Drosophila melanogaster)	Insecta	Sec61beta¹	CG10130-PA	66.67(n) 71.58(a)		46080 NM_143780.3 NP_652037.1
worm (Caenorhabditis elegans)	Secernentea	Y38F2AR.9⁶	Protein Y38F2AR.9	62(a)	1 ↔ 1	IV(2388193-2388676)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G60540⁶ SEC61 BETA⁶ (see all 3)	protein transport protein sec61 subunit beta (see all 3)	38(a) 37(a) (see all 3)	many → 1 many → 1 (see all 3)	3(22374963-22375865) 2(18587017-18588377)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	protein transport protein Sec61 subunit beta, puta... protein transport protein Sec61 subunit beta, puta... (see all 4)	34(a) 34(a) (see all 4)	many → 1 many → 1 (see all 4)	12(3718827-3719078) 1(21631362-21631604)

ENSEMBL Gene Tree for SEC61B (if available)
TreeFam Gene Tree for SEC61B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEC61B gene

SEC61B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SEC61B
PGOHUM00000242224

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74718561^1,2	F,	--	71581320(+)	`ATGTCC/GCGGCT`	2	--	int¹		1	NA	120
rs80182147^1,2	F,	--	71581657(+)	`AAGAAG/AATATA`	2	--	int¹		1	NA	120
rs12555763^1,2	C,F,H,	--	71581829(+)	`AAGTCA/TTCTTT`	2	--	int¹ tfbs³		5	NS EA NA	420
rs12554447^1,2	C,F,H	--	71581831(+)	`GTCATC/TTTTTT`	2	--	int¹		4	NS NA	406
rs113436871^1,2		--	71581983(+)	`TGATAC/TATTCA`	2	--	int¹ nc-transcript-variant		1	CSA	2
rs78964159^1,2	C,F,	--	71582078(+)	`AAGGAG/AAGTCA`	2	--	int¹		1	NA	120
rs112410392^1,2		--	71582090(+)	`CAAAAC/ATAACA`	2	--	int¹		1	CSA	1
rs41274648^1,2		--	71583027(+)	`CCTTCG/CGTAGG`	2	--	us2k¹		2	CSA NA	122
rs17553684^1,2	C,F	--	71583283(-)	`GATGAG/AGGTGG`	2	--	us2k¹		2	EA MN	400
rs7028416^1,2	C,F,H,	--	71583357(+)	`CTTTGC/TGCCGT`	2	--	us2k¹		6	NS NA WA	910

HapMap Linkage Disequilibrium report for SEC61B (101984346 - 101992901 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEC61B: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC61B

DNA2.0 Custom Variant and Variant Library Synthesis for SEC61B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEC61B for disorders           About GeneDecksing

OMIM gene information: 609214    OMIM disorders: --

3 diseases for SEC61B:    About MalaCards

cystic fibrosis cholera fibrosis

Export disorders for SEC61B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEC61B gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with SEC61B)

Utopia: connect your pdf to the dynamic
world of online information

Evolutionary conservation of components of the protein translocation complex. (PubMed id 8107851)^{1, 2, 3} Hartmann E....Rapoport T.A. (1994)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mammalian Sec61 is associated with Sec62 and Sec63. (PubMed id 10799540)^{1, 2} Meyer H.A....Hartmann E. (2000)
The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PubMed id 10212142)^{1, 3} Greenfield J.J. and High S. (1999)
Sec61b controls sensitivity to platinum-containing che motherapeutic agents through modulation of the copper-transporting ATPase ATP7A. (PubMed id 22710939)¹ Abada P.B....Howell S.B. (2012)
Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)¹ Usenovic M....Krainc D. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)¹ Tarallo R....Weisz A. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10952	HGNC: 16993	AceView: SEC61B	Ensembl:ENSG00000106803	euGenes: HUgn10952
ECgene: SEC61B	Kegg: 10952	H-InvDB: SEC61B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
PharmGKB entry for SEC61B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SEC61B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SEC61B gene
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Patent Information for SEC61B gene:
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SEC61B Gene

Sec61 beta subunit

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SEC61B Gene

Sec61 beta subunit

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