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Aliases for SEC61B Gene

Aliases for SEC61B Gene

  • Sec61 Translocon Beta Subunit 2 3 5
  • Sec61 Beta Subunit 2

External Ids for SEC61B Gene

Previous GeneCards Identifiers for SEC61B Gene

  • GC09P092784
  • GC09P093728
  • GC00U912984
  • GC09P097364
  • GC09P099064
  • GC09P101024
  • GC09P101984
  • GC09P071583

Summaries for SEC61B Gene

Entrez Gene Summary for SEC61B Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC61B Gene

SEC61B (Sec61 Translocon Beta Subunit) is a Protein Coding gene. Diseases associated with SEC61B include Polycystic Kidney Disease 4, With Or Without Hepatic Disease. Among its related pathways are Protein processing in endoplasmic reticulum and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and epidermal growth factor binding.

UniProtKB/Swiss-Prot for SEC61B Gene

  • Necessary for protein translocation in the endoplasmic reticulum.

Gene Wiki entry for SEC61B Gene

Additional gene information for SEC61B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61B Gene

Genomics for SEC61B Gene

Regulatory Elements for SEC61B Gene

Enhancers for SEC61B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H099257 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +37.1 37087 3.4 PKNOX1 ATF1 ZBTB40 YY1 ZNF766 CEBPB USF2 REST HDAC8 ZNF592 INVS ALG2 SEC61B STX17 KRT8P11 GC09P099237 RN7SKP225
GH09H099252 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +31.3 31312 2.3 HDGF PKNOX1 TBL1XR1 BATF ZNF143 ZNF207 ATF7 ETV6 RUNX3 CREM SEC61B ALG2 GC09P099237 RN7SKP225
GH09H099181 1.5 FANTOM5 Ensembl ENCODE 11.9 -40.3 -40312 1.1 TBL1XR1 BMI1 BATF ZNF143 ZNF207 ATF7 ETV6 RUNX3 CREM IKZF2 ALG2 STX17 SEC61B LOC105376174 RNA5SP290 GC09M099146
GH09H099266 1.5 FANTOM5 Ensembl ENCODE 11.8 +44.6 44635 0.6 ATF1 FOXA2 MLX ARID4B DMAP1 ZNF2 SLC30A9 GLIS2 ZNF143 FOS ALG2 SEC61B RN7SKP225 GC09P099237
GH09H099244 1.2 FANTOM5 ENCODE 11.9 +23.1 23059 0.2 HDGF PKNOX1 RB1 BMI1 YBX1 ZNF366 ATF7 ETV6 RUNX3 CREM SEC61B ALG2 GC09P099237 RN7SKP225
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC61B on UCSC Golden Path with GeneCards custom track

Promoters for SEC61B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000238785 -64 2801 HDGF PKNOX1 ARNT ZFP64 SIN3A DMAP1 ZBTB7B YY1 ZNF143 ZNF207

Genomic Locations for SEC61B Gene

Genomic Locations for SEC61B Gene
8,556 bases
Plus strand

Genomic View for SEC61B Gene

Genes around SEC61B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61B Gene

Proteins for SEC61B Gene

  • Protein details for SEC61B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein transport protein Sec61 subunit beta
    Protein Accession:
    Secondary Accessions:
    • P38390
    • P38391
    • Q6IBC1

    Protein attributes for SEC61B Gene

    96 amino acids
    Molecular mass:
    9974 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.

neXtProt entry for SEC61B Gene

Post-translational modifications for SEC61B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC61B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC61B Gene

Domains & Families for SEC61B Gene

Gene Families for SEC61B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SEC61B Gene

Suggested Antigen Peptide Sequences for SEC61B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC61-beta family.
  • Belongs to the SEC61-beta family.
genes like me logo Genes that share domains with SEC61B: view

Function for SEC61B Gene

Molecular function for SEC61B Gene

UniProtKB/Swiss-Prot Function:
Necessary for protein translocation in the endoplasmic reticulum.

Phenotypes From GWAS Catalog for SEC61B Gene

Gene Ontology (GO) - Molecular Function for SEC61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
GO:0005515 protein binding IPI 9792704
GO:0015450 contributes_to P-P-bond-hydrolysis-driven protein transmembrane transporter activity IBA --
GO:0048408 epidermal growth factor binding IPI 19602593
genes like me logo Genes that share ontologies with SEC61B: view
genes like me logo Genes that share phenotypes with SEC61B: view

miRNA for SEC61B Gene

miRTarBase miRNAs that target SEC61B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61B Gene

Localization for SEC61B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61B Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC61B gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEC61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA,IEA 18555783
GO:0005784 Sec61 translocon complex IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
genes like me logo Genes that share ontologies with SEC61B: view

Pathways & Interactions for SEC61B Gene

genes like me logo Genes that share pathways with SEC61B: view

Gene Ontology (GO) - Biological Process for SEC61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 17215517
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation IBA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SEC61B: view

No data available for SIGNOR curated interactions for SEC61B Gene

Drugs & Compounds for SEC61B Gene

No Compound Related Data Available

Transcripts for SEC61B Gene

mRNA/cDNA for SEC61B Gene

Unigene Clusters for SEC61B Gene

Sec61 beta subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - - - - - -
SP3: - - -
SP4: - -

Relevant External Links for SEC61B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC61B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC61B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61B Gene

This gene is overexpressed in Nasal epithelium (18.1) and Bone (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC61B Gene

Protein tissue co-expression partners for SEC61B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC61B Gene:


SOURCE GeneReport for Unigene cluster for SEC61B Gene:


Evidence on tissue expression from TISSUES for SEC61B Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Spleen(2.2)
  • Lung(2.1)
  • Pancreas(2.1)
  • Adrenal gland(2)
  • Bone marrow(2)
  • Lymph node(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with SEC61B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC61B Gene

Orthologs for SEC61B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC61B 33 34
  • 100 (n)
(Monodelphis domestica)
Mammalia SEC61B 34
  • 96 (a)
(Canis familiaris)
Mammalia SEC61B 33 34
  • 93.75 (n)
(Bos Taurus)
Mammalia SEC61B 33 34
  • 93.4 (n)
(Rattus norvegicus)
Mammalia Sec61b 33
  • 89.93 (n)
(Mus musculus)
Mammalia Sec61b 33 16 34
  • 88.89 (n)
(Gallus gallus)
Aves SEC61B 33 34
  • 81.6 (n)
(Anolis carolinensis)
Reptilia SEC61B 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec61b 33
  • 73.61 (n)
Str.1470 33
African clawed frog
(Xenopus laevis)
Amphibia sec61beta-prov 33
(Danio rerio)
Actinopterygii sec61b 33 34
  • 72.92 (n)
Dr.28987 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8291 33
fruit fly
(Drosophila melanogaster)
Insecta Sec61beta 33 34
  • 66.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011504 33
  • 62.46 (n)
(Caenorhabditis elegans)
Secernentea Y38F2AR.9 34
  • 60 (a)
(Triticum aestivum)
Liliopsida Ta.11126 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
Species where no ortholog for SEC61B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SEC61B Gene

Gene Tree for SEC61B (if available)
Gene Tree for SEC61B (if available)

Paralogs for SEC61B Gene Pseudogenes for SEC61B Gene

genes like me logo Genes that share paralogs with SEC61B: view

No data available for Paralogs for SEC61B Gene

Variants for SEC61B Gene

Sequence variations from dbSNP and Humsavar for SEC61B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs730882051 Pathogenic 99,221,692(-) ACCGG(G/T)GCGCT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs730882123 Pathogenic 99,221,671(-) GTGCC(AGTCCCCG/GGGGACTGGCT)GCCGC nc-transcript-variant, upstream-variant-2KB, cds-indel
rs11545137 Likely benign 99,221,864(-) GGGAC(C/T)CGGTT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs35055733 Likely benign 99,221,766(+) CACCC(C/G)CGCGC nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs61744789 Likely benign 99,221,811(+) TCAGC(C/G)CCGCC nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SEC61B Gene

Variant ID Type Subtype PubMed ID
nsv831666 CNV gain 17160897
nsv477966 CNV novel sequence insertion 20440878
esv3621214 CNV gain 21293372

Variation tolerance for SEC61B Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC61B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC61B Gene

Disorders for SEC61B Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEC61B Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SEC61B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SEC61B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEC61B Gene

Publications for SEC61B Gene

  1. Evolutionary conservation of components of the protein translocation complex. (PMID: 8107851) Hartmann E … Rapoport TA (Nature 1994) 2 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Mammalian Sec61 is associated with Sec62 and Sec63. (PMID: 10799540) Meyer HA … Hartmann E (The Journal of biological chemistry 2000) 3 4 60

Products for SEC61B Gene

Sources for SEC61B Gene

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