SEC61B Gene
protein-coding GIFtS: 52
GCID: GC09P101984
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Sec61 beta subunit
| |
Aliases for SEC61B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Sec61 Beta Subunit1 2 | | Protein Translocation Complex Beta2 | | Protein Transport Protein SEC61 Beta Subunit2 | | Protein Transport Protein Sec61 Subunit Beta2 | | Sec61 Complex, Beta Subunit2 |
Export aliases for SEC61B gene to outside databasesPrevious GC identifers: GC09P092784 GC09P093728 GC00U912984 GC09P097364 GC09P099064 GC09P101024 GC09P071583 |
Summaries for SEC61B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SEC61B: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER)membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across andintegrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This geneencodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting thatthese proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for thistranscript. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468Function: Necessary for protein translocation in the endoplasmic reticulum Gene Wiki entry for SEC61B
|
Genomic Views for SEC61B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SEC61B gene promoter: GR Bach1 E2F-4 E2F-3a E2F-5 E2F-2 E47 E2F E2F-1 GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for SEC61B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC61B |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q22.32-q31.3 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.32-q31.3SEC61B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P101984: view genomic region
(about GC identifiers)
Start:
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101,984,346 bp from pter |
End:
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101,992,901 bp from pter |
Size:
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8,556 bases |
Orientation:
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plus strand |
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Proteins for SEC61B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468 (See
protein sequence)Recommended Name: Protein transport protein Sec61 subunit beta Size: 96 amino acids; 9974 Da
Subunit: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed ofSEC61, SEC62 and SEC63. Interacts with SEC62
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Secondary accessions: P38390 P38391 Q6IBC1Explore the universe of human proteins at neXtProt for SEC61B: NX_P60468
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P60468 SEC61B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006799.1 ENSEMBL proteins: ENSP00000223641 Reactome Protein details: P60468 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SEC61B for ontologies About GeneDecksing
SEC61B Antibody Products: Assay Products for SEC61B: |
Protein
Domains / Families for SEC61B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEC61B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P60468ProtoNet protein and cluster: P60468 1 Blocks protein family: IPB005609 Sec61beta
UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468Similarity: Belongs to the SEC61-beta family |
Function for SEC61B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SC61B_HUMAN, P60468Function: Necessary for protein translocation in the endoplasmic reticulum
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SEC61B (NM_006808) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC61B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC61B  |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SEC61B for ontologies About GeneDecksing
|
Pathways & Interactions for SEC61B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of degradation of wt-CFTR | | | 2 | Immune System | | | 3 | Immune response Antigen presentation by MHC class I | | | 4 | Synthesis of PB1-F2 | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources See GeneCards unified pathways Show all pathways
1 EMD Millipore Pathway for SEC61B 1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC61B 3 GeneGo (Thomson Reuters) Pathways for SEC61B 5/9
Reactome Pathways for SEC61B (see all 9)
4
Kegg Pathways (Kegg details for SEC61B):
SEC61B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC61B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/147 Interacting proteins for SEC61B (P604681, 2, 3 ENSP000002236414) via UniProtKB, MINT, STRING, and/or I2D (see all 147)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000060 | protein import into nucleus, translocation |
IMP | 17215517 | | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
TAS | -- | | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
TAS | -- |
SEC61B for ontologies About GeneDecksing
|
Drugs & Compounds for SEC61B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SEC61B Search CenterWatch for drugs/clinical trials and news about SEC61B / SC61B 
|
Transcripts for SEC61B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SEC61B gene: NM_006808.2 Unigene Cluster for SEC61B: Sec61 beta subunit Hs.191887 [show with all ESTs]Unigene Representative Sequence: BG5738433 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000498603 ENST00000223641(uc004azh.3) ENST00000481573
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SEC61B (NM_006808) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC61B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC61B  |
Additional cDNA sequence: AJ293399.1 AK223384.1 BC001734.1 CR456883.1 CR542159.1 L25085.1 9 DOTS entries: DT.115567 DT.204367 DT.86855687 DT.75125416 DT.95110708 DT.91756687 DT.95194876 DT.121166168 DT.40228340 24/221 AceView cDNA sequences (see all 221): BF444920 BM768855 BU634312 AI912692 BM799831 AI281953 BM674319 BG032213 AI457230 BQ645681 BM785224 AI279456 BM353497 BU072902 BG257925 AA083469 BF726545 BC001734 AA305690 BQ918672 CR542159 BE327671 CA941830 BM045148 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SEC61B About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | - |   | - |   | - |   | |   | - |   | - |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SEC61B
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Expression for SEC61B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEC61B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGAGAAATTT
About this image See SEC61B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SEC61B
SOURCE GeneReport for Unigene cluster: Hs.191887 SABiosciences Custom PCR Arrays for SEC61B
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC61B Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC61B | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC61B | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC61B |
Orthologs for SEC61B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SEC61B gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for SEC61B (if available) TreeFam Gene Tree for SEC61B (if available)  |
Paralogs for SEC61B gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SEC61B gene
SEC61B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SEC61B PGOHUM00000242224
|
Genomic Variants for SEC61B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SEC61B (101984346 - 101992901 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SEC61B: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC61B |
|
Disorders
/ Diseases for SEC61B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SEC61B for disorders About GeneDecksing
OMIM gene information: 609214
OMIM disorders: --
3 diseases for SEC61B: About MalaCardscystic fibrosis cholera fibrosis Export disorders for SEC61B gene to outside databases
|
Publications for SEC61B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEC61B gene, integrated from 9 sources (see all 37): (articles sorted by number of sources associating them with SEC61B) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Evolutionary conservation of components of the protein translocation complex. (PubMed id 8107851)1, 2, 3 Hartmann E....Rapoport T.A. (1994)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mammalian Sec61 is associated with Sec62 and Sec63. (PubMed id 10799540)1, 2 Meyer H.A....Hartmann E. (2000)
- The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PubMed id 10212142)1, 3 Greenfield J.J. and High S. (1999)
- Sec61b controls sensitivity to platinum-containing che motherapeutic agents through modulation of the copper-transporting ATPase ATP7A. (PubMed id 22710939)1 Abada P.B....Howell S.B. (2012)
- Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
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External Searches for SEC61B gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SEC61B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SEC61B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SEC61B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for SEC61B gene: Search GeneIP for patents involving SEC61B
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SEC61B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for SEC61B | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC61B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC61B | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for SEC61B | | OriGene 3'-UTR Clone for SEC61B | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61B | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for SEC61B | | OriGene Custom Protein Services for SEC61B | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC61B | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC61B | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC61B | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC61B | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC61B | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC61B |
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| | | Search Tocris compounds for SEC61B |
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 | | | | |  |  |  | | | ThermoFisher Antibody for SEC61B |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC61B |
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