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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC61A2 Gene

protein-coding   GIFtS: 53
GCID: GC10P012171

Sec61 Alpha 2 Subunit (S. Cerevisiae)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sec61 Alpha 2 Subunit (S. Cerevisiae)1 2
Sec61 Alpha-22 3
Protein Transport Protein Sec61 Subunit Alpha2
Protein Transport Protein Sec61 Subunit Alpha Isoform 22
Sec61 Alpha Form 22

External Ids:    HGNC: 177021   Entrez Gene: 551762   Ensembl: ENSG000000656657   UniProtKB: Q9H9S33   
ORGUL members:         
NONCODE14:n407080 n407079      

Export aliases for SEC61A2 gene to outside databases

Previous GC identifers: GC10P012056 GC00U912983 GC10P012175 GC10P012211 GC10P012088


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC61A2 Gene:
The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of
secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of
membrane and secretory proteins. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Dec 2008)

GeneCards Summary for SEC61A2 Gene: 
SEC61A2 (Sec61 alpha 2 subunit (S. cerevisiae)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SEC61A2 include cholera, and alzheimer's disease, and among its related super-pathways are ER-Phagosome pathway and Viral mRNA Translation. GO annotations related to this gene include ribosome binding and molecular_function. An important paralog of this gene is SEC61A1.

UniProtKB/Swiss-Prot: S61A2_HUMAN, Q9H9S3
Function: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It
is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound
ribosomes, either directly or through adaptor proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC61A2 gene promoter:
         AML1a   Brachyury   FOXD1   HSF1 (long)   Pax-2   IRF-1   Pax-2a   C/EBPalpha   FOXL1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC61A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC61A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC61A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p14

SEC61A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC61A2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P012171:  view genomic region     (about GC identifiers)

Start:
12,171,636 bp from pter      End:
12,211,960 bp from pter
Size:
40,325 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SEC61A2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S61A2_HUMAN, Q9H9S3 (See protein sequence)
Recommended Name: Protein transport protein Sec61 subunit alpha isoform 2  
Size: 476 amino acids; 52248 Da
Subunit: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A8K8D0 B4DX72 F8W773
Alternative splicing: 3 isoforms:  Q9H9S3-1   Q9H9S3-2   Q9H9S3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC61A2: NX_Q9H9S3

Explore proteomics data for SEC61A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H9S3

  • SEC61A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEC61A2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001136099.1  NP_001136100.1  NP_060614.2  

    ENSEMBL proteins: 
     ENSP00000368339   ENSP00000404959   ENSP00000436749   ENSP00000298428   ENSP00000302048  
     ENSP00000436294   ENSP00000368306   ENSP00000368302   ENSP00000401731   ENSP00000393214  
     ENSP00000402124   ENSP00000368319  
    Reactome Protein details: Q9H9S3
    Human Recombinant Protein Products for SEC61A2: 
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    Novus Biologicals SEC61A2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SEC61A2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR023201 SecY_su_dom
     IPR002208 SecY/SEC61-alpha
     IPR019561 Translocon_Sec61/SecY_plug_dom

    Graphical View of Domain Structure for InterPro Entry Q9H9S3

    ProtoNet protein and cluster: Q9H9S3

    1 Blocks protein domain: IPB002208 SecY protein

    UniProtKB/Swiss-Prot: S61A2_HUMAN, Q9H9S3
    Similarity: Belongs to the SecY/SEC61-alpha family


    SEC61A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S61A2_HUMAN, Q9H9S3
    Function: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It
    is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound
    ribosomes, either directly or through adaptor proteins (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0043022ribosome binding IEA--
         
    SEC61A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEC61A2:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Sec61a2 (no phenotypes)

    SEC61A2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEC61A2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEC61A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC61A2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC61A2 

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC61A2 (see all 43):
    hsa-miR-548j hsa-miR-429 hsa-miR-99b* hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-124 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSEC61A2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC61A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEC61A2 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.81
    Antigen processing-Cross presentation0.81
    2Viral mRNA Translation
    Translation0.78
    SRP-dependent cotranslational protein targeting to membrane0.77
    3Regulation of degradation of wt-CFTR
    Regulation of degradation of deltaF508 CFTR in CF0.59
    Regulation of degradation of wt-CFTR0.59
    4Immune System
    Immune System0.56
    Adaptive Immune System0.56
    5Immune response Antigen presentation by MHC class I
    Immune response Antigen presentation by MHC class I0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SEC61A2
        Immune response Antigen presentation by MHC class I

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC61A2
        Cholera Infection

    3 GeneGo (Thomson Reuters) Pathways for SEC61A2
        Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    5/9        Reactome Pathways for SEC61A2 (see all 9)
        Translation
    Antigen processing-Cross presentation
    SRP-dependent cotranslational protein targeting to membrane
    Adaptive Immune System
    ER-Phagosome pathway


    4         Kegg Pathways  (Kegg details for SEC61A2):
        Protein export
    Protein processing in endoplasmic reticulum
    Phagosome
    Vibrio cholerae infection


    SEC61A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC61A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for SEC61A2 (Q9H9S33 ENSP000002984284) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBP041143, ENSP000002332424I2D: score=1 STRING: ENSP00000233242
    USP19O949663, ENSP000003818634I2D: score=2 STRING: ENSP00000381863
    CLN3Q132863, ENSP000003530734I2D: score=3 STRING: ENSP00000353073
    CNOT10Q9H9A53I2D: score=5 
    SF3A3Q128743I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0008150biological_process ND--
    GO:0015031protein transport IEA--
    GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I TAS--

    SEC61A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC61A2 (S61A2)

    Search CenterWatch for drugs/clinical trials and news about SEC61A2 / S61A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC61A2 gene (3 alternative transcripts): 
    NM_001142627.1  NM_001142628.1  NM_018144.3  

    Unigene Cluster for SEC61A2:

    Sec61 alpha 2 subunit (S. cerevisiae)
    Hs.112955  [show with all ESTs]
    Unigene Representative Sequence: NM_018144
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379051 ENST00000441368 ENST00000475268(uc001ilh.4 uc001ilg.4)
    ENST00000298428 ENST00000495368(uc001ilf.4) ENST00000304267 ENST00000472221
    ENST00000379020 ENST00000379017 ENST00000457034 ENST00000418772 ENST00000419021
    ENST00000466451 ENST00000379033(uc001ile.2 uc010qbq.1)

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC61A2 (see all 43):
    hsa-miR-548j hsa-miR-429 hsa-miR-99b* hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-124 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSEC61A2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC61A2
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    Additional mRNA sequence: 

    AF346603.1 AK001440.1 AK022027.1 AK022640.1 AK057532.1 AK292295.1 AK301841.1 BC026179.1 
    NR_024576.1 NR_024577.1 

    17 DOTS entries:

    DT.417545  DT.451643  DT.86852431  DT.97839588  DT.95373278  DT.215957  DT.97839587  DT.95080179 
    DT.95255517  DT.100697653  DT.102831352  DT.40121371  DT.100742830  DT.121284499  DT.121284697  DT.40271460 
    DT.91773611 

    24/119 AceView cDNA sequences (see all 119):

    AA918663 N91876 CR607709 BX453009 AW295825 AI141531 AA322680 AA916221 
    AK022027 BX453664 AA644274 AK001440 AU120635 BX477824 BG723109 BF433631 
    BF445225 AW968735 AU125111 AW340366 BG910449 AI733125 AW293140 AL521445 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC61A2 expression in normal human tissues (normalized intensities)      SEC61A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAAAAAA
    SEC61A2 Expression
    About this image


    SEC61A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Bone (Muscoskeletal System)
             Mandibular Condyle

    See SEC61A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC61A2

    SOURCE GeneReport for Unigene cluster: Hs.112955
        SABiosciences Custom PCR Arrays for SEC61A2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC61A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC61A2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec61a21 , 5 Sec61, alpha subunit 2 (S. cerevisiae)1, 5 90.48(n)1
    100(a)1
      2 (3.62 cM)5
    577431  NM_021305.31  NP_067280.11 
     58709875 
    chicken
    (Gallus gallus)
    Aves SEC61A21 Sec61 alpha 2 subunit (S. cerevisiae) 85.15(n)
    99.58(a)
      426369  XM_424024.3  XP_424024.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sec61alpha1 CG9539-PA 74.93(n)
    91.18(a)
      33905  NM_135190.4  NP_609034.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y57G11C.151 Protein Y57G11C.15 71.88(n)
    87.53(a)
      178407  NM_070392.6  NP_502793.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC616
    Essential subunit of Sec61 complex (Sec61p, Sbh1p,...
    54(a)
    1 → many
    XII(875736-877178)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G787201 protein transport protein SEC61 subunit alpha 65.67(n)
    70.36(a)
      844208  NM_106519.1  NP_177993.1 


    ENSEMBL Gene Tree for SEC61A2 (if available)
    TreeFam Gene Tree for SEC61A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC61A2 gene
    SEC61A12  
    1 SIMAP similar gene for SEC61A2 using alignment to 10 protein entries:     S61A2_HUMAN (see all proteins):
    SEC61A1

    SEC61A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/798 SNPs in SEC61A2 are shown (see all 798)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs97940691,2
    C,H--12169659(+) CCTGAC/AAAGCT 5 -- us2k112Minor allele frequency- A:0.02NA WA CSA 257
    rs97940701,2
    C,F,A--12169669(+) TGGGAC/AAACAG 5 -- us2k112Minor allele frequency- A:0.32NA WA CSA EA 376
    rs1428666141,2
    --12169677(+) CAGGCA/GCAAAC 5 -- us2k10--------
    rs1884363691,2
    --12169805(+) GCTCAA/TAATTG 5 -- us2k10--------
    rs1439938791,2
    C--12170042(+) CCCAC-/ATGTTCT 5 -- us2k10--------
    rs755277221,2
    F--12170129(+) TAAAAG/TATGCT 5 -- us2k11Minor allele frequency- T:0.03WA 118
    rs66025631,2
    C,F,A,H--12170174(+) TGCCAT/CGCTGT 5 -- us2k125Minor allele frequency- C:0.43NS EA NA WA CSA 2351
    rs611880891,2
    C,F--12170195(+) AGGCCG/ACTTGG 5 -- us2k12Minor allele frequency- A:0.14WA EA 238
    rs1450383621,2
    --12170212(+) CATCTA/GGAGGT 5 -- us2k10--------
    rs1164326961,2
    C,F--12170232(+) GACACC/GAGCAC 5 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for SEC61A2 (12171636 - 12211960 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SEC61A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675175CNV Deletion23128226
    esv2733095CNV Deletion23290073
    nsv5820CNV Insertion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SEC61A2:    About MalaCards
    cholera    alzheimer's disease


    SEC61A2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SEC61A2
    Human Genome Epidemiology (HuGE) Navigator: SEC61A2 (1 document)

    Export disorders for SEC61A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC61A2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SEC61A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    6. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    7. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    9. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PubMed id 17110338)1 Wang X....Balch W.E. (2006)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55176 HGNC: 17702 AceView: SEC61A2 Ensembl:ENSG00000065665 euGenes: HUgn55176
    ECgene: SEC61A2 Kegg: 55176 H-InvDB: SEC61A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC61A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC61A2 gene:
    Search GeneIP for patents involving SEC61A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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