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Aliases for SEC61A2 Gene

Aliases for SEC61A2 Gene

  • Sec61 Translocon Alpha 2 Subunit 2 3 5
  • Sec61 Alpha 2 Subunit (S. Cerevisiae) 2
  • Sec61 Alpha-2 4

External Ids for SEC61A2 Gene

Previous GeneCards Identifiers for SEC61A2 Gene

  • GC10P012056
  • GC00U912983
  • GC10P012175
  • GC10P012211
  • GC10P012171
  • GC10P012088

Summaries for SEC61A2 Gene

Entrez Gene Summary for SEC61A2 Gene

  • The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for SEC61A2 Gene

SEC61A2 (Sec61 Translocon Alpha 2 Subunit) is a Protein Coding gene. Among its related pathways are Phagosome and Protein export. GO annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A1.

UniProtKB/Swiss-Prot for SEC61A2 Gene

  • Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61A2 Gene

Genomics for SEC61A2 Gene

Regulatory Elements for SEC61A2 Gene

Enhancers for SEC61A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEC61A2 on UCSC Golden Path with GeneCards custom track

Promoters for SEC61A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC61A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC61A2 Gene

Chromosome:
10
Start:
12,129,637 bp from pter
End:
12,169,961 bp from pter
Size:
40,325 bases
Orientation:
Plus strand

Genomic View for SEC61A2 Gene

Genes around SEC61A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61A2 Gene

Proteins for SEC61A2 Gene

  • Protein details for SEC61A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9S3-S61A2_HUMAN
    Recommended name:
    Protein transport protein Sec61 subunit alpha isoform 2
    Protein Accession:
    Q9H9S3
    Secondary Accessions:
    • A8K8D0
    • B4DX72
    • F8W773

    Protein attributes for SEC61A2 Gene

    Size:
    476 amino acids
    Molecular mass:
    52248 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

    Alternative splice isoforms for SEC61A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC61A2 Gene

Proteomics data for SEC61A2 Gene at MOPED

Post-translational modifications for SEC61A2 Gene

  • Ubiquitination at Lys 4
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC61A2 Gene

Domains & Families for SEC61A2 Gene

Protein Domains for SEC61A2 Gene

Suggested Antigen Peptide Sequences for SEC61A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9S3

UniProtKB/Swiss-Prot:

S61A2_HUMAN :
  • Belongs to the SecY/SEC61-alpha family.
Family:
  • Belongs to the SecY/SEC61-alpha family.
genes like me logo Genes that share domains with SEC61A2: view

No data available for Gene Families for SEC61A2 Gene

Function for SEC61A2 Gene

Molecular function for SEC61A2 Gene

UniProtKB/Swiss-Prot Function:
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).
genes like me logo Genes that share phenotypes with SEC61A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEC61A2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61A2 Gene

Localization for SEC61A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61A2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC61A2 Gene COMPARTMENTS Subcellular localization image for SEC61A2 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SEC61A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SEC61A2: view

Pathways & Interactions for SEC61A2 Gene

genes like me logo Genes that share pathways with SEC61A2: view

Gene Ontology (GO) - Biological Process for SEC61A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SEC61A2: view

No data available for SIGNOR curated interactions for SEC61A2 Gene

Drugs & Compounds for SEC61A2 Gene

No Compound Related Data Available

Transcripts for SEC61A2 Gene

Unigene Clusters for SEC61A2 Gene

Sec61 alpha 2 subunit (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61A2 Gene

No ASD Table

Relevant External Links for SEC61A2 Gene

GeneLoc Exon Structure for
SEC61A2
ECgene alternative splicing isoforms for
SEC61A2

Expression for SEC61A2 Gene

mRNA expression in normal human tissues for SEC61A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61A2 Gene

This gene is overexpressed in Testis (37.9), Ovary (9.6), Retina (9.6), and Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC61A2 Gene



SOURCE GeneReport for Unigene cluster for SEC61A2 Gene Hs.112955

genes like me logo Genes that share expression patterns with SEC61A2: view

Protein tissue co-expression partners for SEC61A2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC61A2 Gene

Orthologs for SEC61A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC61A2 35
  • 92.86 (n)
  • 100 (a)
SEC61A2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC61A2 35
  • 92.69 (n)
  • 100 (a)
SEC61A2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec61a2 35
  • 90.48 (n)
  • 100 (a)
Sec61a2 16
Sec61a2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC61A2 35
  • 99.3 (n)
  • 100 (a)
SEC61A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec61a2 35
  • 90.34 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC61A2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC61A2 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC61A2 35
  • 85.05 (n)
  • 99.37 (a)
SEC61A2 36
  • 100 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009182 35
  • 72.86 (n)
  • 91.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sec61alpha 35
  • 74.93 (n)
  • 91.18 (a)
Sec61alpha 36
  • 91 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.15 35
  • 71.88 (n)
  • 87.53 (a)
sec-61 36
  • 87 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC61 36
  • 54 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G78720 35
  • 65.67 (n)
  • 70.36 (a)
soybean
(Glycine max)
eudicotyledons Gma.2468 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4836 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11324 36
  • 80 (a)
OneToMany
Species with no ortholog for SEC61A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SEC61A2 Gene

ENSEMBL:
Gene Tree for SEC61A2 (if available)
TreeFam:
Gene Tree for SEC61A2 (if available)

Paralogs for SEC61A2 Gene

Paralogs for SEC61A2 Gene

(1) SIMAP similar genes for SEC61A2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SEC61A2: view

Variants for SEC61A2 Gene

Sequence variations from dbSNP and Humsavar for SEC61A2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1573986 -- 12,161,322(+) agccc(A/G)tggtc intron-variant
rs1573987 -- 12,161,357(+) gagca(G/T)taacg intron-variant
rs3060441 -- 12,129,191(+) gagac(-/TC)tgttt upstream-variant-2KB
rs3060465 -- 12,163,337(+) ttttt(-/TT)atctg intron-variant
rs3758374 -- 12,154,317(+) TGTGA(A/C)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC61A2 Gene

Variant ID Type Subtype PubMed ID
esv2733095 CNV Deletion 23290073
esv2675175 CNV Deletion 23128226
nsv5820 CNV Insertion 18451855

Variation tolerance for SEC61A2 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 69.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC61A2 Gene

HapMap Linkage Disequilibrium report
SEC61A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC61A2 Gene

Disorders for SEC61A2 Gene

Relevant External Links for SEC61A2

Genetic Association Database (GAD)
SEC61A2
Human Genome Epidemiology (HuGE) Navigator
SEC61A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC61A2

No disorders were found for SEC61A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC61A2 Gene

Publications for SEC61A2 Gene

  1. Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome. (PMID: 18480044) Daniel C.J. … Skach W.R. (J. Biol. Chem. 2008) 2 3 67
  2. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PMID: 10212142) Greenfield J.J. … High S. (J. Cell. Sci. 1999) 2 3
  3. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3

Products for SEC61A2 Gene

Sources for SEC61A2 Gene

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