External Ids for SEC61A2 Gene
Previous GeneCards Identifiers for SEC61A2 Gene
The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
GeneCards Summary for SEC61A2 Gene
SEC61A2 (Sec61 Alpha 2 Subunit (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A1.
UniProtKB/Swiss-Prot for SEC61A2 Gene
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).