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Aliases for SEC61A2 Gene

Aliases for SEC61A2 Gene

  • Sec61 Translocon Alpha 2 Subunit 2 3 5
  • Sec61 Alpha 2 Subunit (S. Cerevisiae) 2
  • Sec61 Alpha-2 4

External Ids for SEC61A2 Gene

Previous GeneCards Identifiers for SEC61A2 Gene

  • GC10P012056
  • GC00U912983
  • GC10P012175
  • GC10P012211
  • GC10P012171
  • GC10P012088

Summaries for SEC61A2 Gene

Entrez Gene Summary for SEC61A2 Gene

  • The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for SEC61A2 Gene

SEC61A2 (Sec61 Translocon Alpha 2 Subunit) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Viral mRNA Translation. GO annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A1.

UniProtKB/Swiss-Prot for SEC61A2 Gene

  • Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).

Additional gene information for SEC61A2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61A2 Gene

Genomics for SEC61A2 Gene

Regulatory Elements for SEC61A2 Gene

Enhancers for SEC61A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H012179 0.8 Ensembl ENCODE 21.2 +51.4 51442 2 POLR2A MAX REST MYC SEC61A2 DHTKD1 NUDT5 PIR56929 CDC123
GH10H012128 1 ENCODE 10.9 0.0 -12 2 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 ZNF143 DHTKD1 UPF2 SEC61A2 NUDT5 GC10P012129
GH10H012194 0.8 ENCODE 11.1 +63.8 63840 0 YY1 ZNF366 SCRT2 FOS ZNF362 USF2 CEBPB ZEB2 PRDM6 KLF16 SEC61A2 DHTKD1 NUDT5 CDC123 PIR56929
GH10H012073 0.7 ENCODE 11.8 -54.9 -54934 2 HDGF ZBED1 TRIM22 ZNF217 IKZF1 TARDBP NBN MLLT1 ATF7 ZNF600 SEC61A2 UPF2 PROSER2-AS1 DHTKD1 GC10P012093
GH10H011890 0.8 dbSUPER 10 -237.8 -237795 1 ZFP64 ZNF223 ZNF266 ZNF697 FOSL1 E2F1 ZNF791 POLR2A ZNF138 NFE2 UPF2 PROSER2-AS1 ENSG00000228302 PROSER2 SEC61A2 GC10M011888 PIR51152 GC10P011892
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC61A2 on UCSC Golden Path with GeneCards custom track

Promoters for SEC61A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000024514 63 1801 MLX ZFP64 ARID4B SIN3A DMAP1 GLIS2 ZNF143 ZNF207 ATF7 SP3

Genomic Location for SEC61A2 Gene

Chromosome:
10
Start:
12,129,637 bp from pter
End:
12,169,961 bp from pter
Size:
40,325 bases
Orientation:
Plus strand

Genomic View for SEC61A2 Gene

Genes around SEC61A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61A2 Gene

Proteins for SEC61A2 Gene

  • Protein details for SEC61A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9S3-S61A2_HUMAN
    Recommended name:
    Protein transport protein Sec61 subunit alpha isoform 2
    Protein Accession:
    Q9H9S3
    Secondary Accessions:
    • A8K8D0
    • B4DX72
    • F8W773

    Protein attributes for SEC61A2 Gene

    Size:
    476 amino acids
    Molecular mass:
    52248 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

    Alternative splice isoforms for SEC61A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC61A2 Gene

Post-translational modifications for SEC61A2 Gene

  • Ubiquitination at isoforms=2, 34
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC61A2 Gene

Domains & Families for SEC61A2 Gene

Gene Families for SEC61A2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SEC61A2 Gene

Suggested Antigen Peptide Sequences for SEC61A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9S3

UniProtKB/Swiss-Prot:

S61A2_HUMAN :
  • Belongs to the SecY/SEC61-alpha family.
Family:
  • Belongs to the SecY/SEC61-alpha family.
genes like me logo Genes that share domains with SEC61A2: view

Function for SEC61A2 Gene

Molecular function for SEC61A2 Gene

UniProtKB/Swiss-Prot Function:
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).

Phenotypes From GWAS Catalog for SEC61A2 Gene

Gene Ontology (GO) - Molecular Function for SEC61A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with SEC61A2: view
genes like me logo Genes that share phenotypes with SEC61A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEC61A2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SEC61A2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61A2 Gene

Localization for SEC61A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61A2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC61A2 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SEC61A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC61A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEC61A2 Gene

Pathways & Interactions for SEC61A2 Gene

genes like me logo Genes that share pathways with SEC61A2: view

Gene Ontology (GO) - Biological Process for SEC61A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with SEC61A2: view

No data available for SIGNOR curated interactions for SEC61A2 Gene

Drugs & Compounds for SEC61A2 Gene

No Compound Related Data Available

Transcripts for SEC61A2 Gene

Unigene Clusters for SEC61A2 Gene

Sec61 alpha 2 subunit (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SEC61A2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61A2 Gene

No ASD Table

Relevant External Links for SEC61A2 Gene

GeneLoc Exon Structure for
SEC61A2
ECgene alternative splicing isoforms for
SEC61A2

Expression for SEC61A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC61A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61A2 Gene

This gene is overexpressed in Testis (37.9), Ovary (9.6), Retina (9.6), and Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC61A2 Gene



Protein tissue co-expression partners for SEC61A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC61A2 Gene:

SEC61A2

SOURCE GeneReport for Unigene cluster for SEC61A2 Gene:

Hs.112955

Evidence on tissue expression from TISSUES for SEC61A2 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with SEC61A2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC61A2 Gene

Orthologs for SEC61A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61A2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia SEC61A2 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC61A2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC61A2 33 34
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia SEC61A2 33 34
  • 92.86 (n)
dog
(Canis familiaris)
Mammalia SEC61A2 33 34
  • 92.69 (n)
mouse
(Mus musculus)
Mammalia Sec61a2 33 16 34
  • 90.48 (n)
rat
(Rattus norvegicus)
Mammalia Sec61a2 33
  • 90.34 (n)
chicken
(Gallus gallus)
Aves SEC61A2 33 34
  • 85.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sec61alpha 33 34
  • 74.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009182 33
  • 72.86 (n)
worm
(Caenorhabditis elegans)
Secernentea sec-61 34
  • 87 (a)
OneToMany
CELE_Y57G11C.15 33
  • 71.88 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC61 34
  • 54 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G78720 33
  • 65.67 (n)
soybean
(Glycine max)
eudicotyledons Gma.2468 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11324 34
  • 80 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4836 33
Species where no ortholog for SEC61A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SEC61A2 Gene

ENSEMBL:
Gene Tree for SEC61A2 (if available)
TreeFam:
Gene Tree for SEC61A2 (if available)

Paralogs for SEC61A2 Gene

Paralogs for SEC61A2 Gene

(1) SIMAP similar genes for SEC61A2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SEC61A2: view

Variants for SEC61A2 Gene

Sequence variations from dbSNP and Humsavar for SEC61A2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000003758 -- 12,154,125(+) GAACA(C/T)GTAGC intron-variant
rs1000078891 -- 12,155,218(+) AGTAC(A/G)TATTT intron-variant
rs1000203386 -- 12,153,917(+) GAAAT(A/C)TACAT intron-variant
rs1000311819 -- 12,133,557(+) CTTCG(C/G)CCTAT intron-variant
rs1000323179 -- 12,160,671(+) TAATG(A/G)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC61A2 Gene

Variant ID Type Subtype PubMed ID
dgv673n100 CNV gain 25217958
dgv674n100 CNV gain 25217958
esv2675175 CNV deletion 23128226
esv2733095 CNV deletion 23290073
esv3622362 CNV loss 21293372
nsv1035709 CNV gain 25217958
nsv5820 CNV insertion 18451855
nsv958547 CNV deletion 24416366

Variation tolerance for SEC61A2 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 69.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC61A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC61A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC61A2 Gene

Disorders for SEC61A2 Gene

Relevant External Links for SEC61A2

Genetic Association Database (GAD)
SEC61A2
Human Genome Epidemiology (HuGE) Navigator
SEC61A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC61A2

No disorders were found for SEC61A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC61A2 Gene

Publications for SEC61A2 Gene

  1. Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome. (PMID: 18480044) Daniel CJ … Skach WR (The Journal of biological chemistry 2008) 2 3 60
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PMID: 10212142) Greenfield JJ … High S (Journal of cell science 1999) 2 3 60
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60

Products for SEC61A2 Gene

Sources for SEC61A2 Gene

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