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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEC61A2 Gene

protein-coding GIFtS: 52
GCID: GC10P012171

Sec61 alpha 2 subunit (S. cerevisiae)

Explore 3 diseases affiliated with
SEC61A2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sec61 Alpha 2 Subunit (S. Cerevisiae)¹ ²
Sec61 Alpha-2² ³
FLJ10578¹
Protein Transport Protein Sec61 Subunit Alpha²
Protein Transport Protein Sec61 Subunit Alpha Isoform 2²
Sec61 Alpha Form 2²

External Ids:	HGNC: 17702¹	Entrez Gene: 55176²	Ensembl: ENSG00000065665⁷	UniProtKB: Q9H9S3³

ORGUL members:
	NONCODE:n407079 n407080

Export aliases for SEC61A2 gene to outside databases

Previous GC identifers: GC10P012056 GC00U912983 GC10P012175 GC10P012211 GC10P012088

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC61A2:

The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory

and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and

secretory proteins. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: S61A2_HUMAN, Q9H9S3

Function: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is

required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound

ribosomes, either directly or through adaptor proteins (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEC61A2 gene promoter:
AML1a Brachyury FOXD1 HSF1 (long) Pax-2 IRF-1 Pax-2a C/EBPalpha FOXL1 HSF1short
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEC61A2 promoter sequence

Search SABiosciences Chromatin IP Primers for SEC61A2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC61A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14 Ensembl cytogenetic band: 10p14 HGNC cytogenetic band: 10p14

SEC61A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC61A2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P012171: view genomic region (about GC identifiers)

Start:	12,171,636 bp from pter	End:	12,211,960 bp from pter
Size:	40,325 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SEC61A2

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S61A2_HUMAN, Q9H9S3 (See protein sequence)

Recommended Name: Protein transport protein Sec61 subunit alpha isoform 2

Size: 476 amino acids; 52248 Da

Subunit: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: A8K8D0

Alternative splicing: 2 isoforms: Q9H9S3-1 Q9H9S3-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC61A2: NX_Q9H9S3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H9S3

SEC61A2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001136099.1 NP_001136100.1 NP_060614.2

ENSEMBL proteins:

ENSP00000368339 ENSP00000404959 ENSP00000436749 ENSP00000298428 ENSP00000302048

ENSP00000436294 ENSP00000368306 ENSP00000368302 ENSP00000401731 ENSP00000393214

ENSP00000402124 ENSP00000404563 ENSP00000368319

Reactome Protein details: Q9H9S3
Human Recombinant Protein Products for SEC61A2:

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	Novus Biologicals SEC61A2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0030670	phagocytic vesicle membrane	--	--

SEC61A2 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEC61A2 for domains About GeneDecksing

3 InterPro domains/families:

IPR023201 SecY_su_dom

IPR002208 SecY/SEC61-alpha

IPR019561 Translocon_Sec61/SecY_plug_dom

Graphical View of Domain Structure for InterPro Entry Q9H9S3

ProtoNet protein and cluster: Q9H9S3

1 Blocks protein family: IPB002208 SecY protein

UniProtKB/Swiss-Prot: S61A2_HUMAN, Q9H9S3

Similarity: Belongs to the SecY/SEC61-alpha family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S61A2_HUMAN, Q9H9S3

Function: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is

required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound

ribosomes, either directly or through adaptor proteins (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	--	--
GO:0043022	ribosome binding	IEA	--

SEC61A2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SEC61A2:

Increased gamma-H2AX phosphory

1 MGI phenotypic allele

for Sec61a2 (no phenotypes)

SEC61A2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEC61A2

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SEC61A2 Browse MicroRNA Expression Plasmids
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		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC61A2 (see all 43):
		hsa-miR-548j hsa-miR-429 hsa-miR-99b* hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-124 hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SEC61A2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC61A2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of degradation of wt-CFTR

Regulation of degradation of wt-CFTR

1.00

Regulation of degradation of deltaF508 CFTR in CF

0.59

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Immune response Antigen presentation by MHC class I

Immune response Antigen presentation by MHC class I

1.00

Immune response_Antigen presentation by MHC class I

0.92

Synthesis of PB1-F2

SRP-dependent cotranslational protein targeting to membrane

0.77

Translation

0.57

Ubiquitinated Orc1 is degraded by the proteasome

ER-Phagosome pathway

0.74

Antigen processing-Cross presentation

0.60

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SEC61A2

Immune response Antigen presentation by MHC class I

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC61A2

Cholera Infection

3 GeneGo (Thomson Reuters) Pathways for SEC61A2

	Immune response Antigen presentation by MHC class I
	Regulation of degradation of deltaF508 CFTR in CF
	Regulation of degradation of wt-CFTR

5/9 Reactome Pathways for SEC61A2 (see all 9)

	Translation
	Antigen processing-Cross presentation
	SRP-dependent cotranslational protein targeting to membrane
	Adaptive Immune System
	ER-Phagosome pathway

4 Kegg Pathways (Kegg details for SEC61A2):

	Protein export
	Protein processing in endoplasmic reticulum
	Phagosome
	Vibrio cholerae infection

SEC61A2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEC61A2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for SEC61A2 (Q9H9S3³ ENSP00000298428⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOB	P04114³, ENSP00000233242⁴	I2D: score=1 STRING: ENSP00000233242
USP19	O94966³, ENSP00000381863⁴	I2D: score=2 STRING: ENSP00000381863
CLN3	Q13286³, ENSP00000353073⁴	I2D: score=3 STRING: ENSP00000353073
CNOT10	Q9H9A5³	I2D: score=5
SF3A3	Q12874³	I2D: score=5

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0008150	biological_process	ND	--
GO:0015031	protein transport	IEA	--
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	TAS	--

SEC61A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEC61A2
Search CenterWatch for drugs/clinical trials and news about SEC61A2 / S61A2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEC61A2 gene (3 alternative transcripts):

NM_001142627.1 NM_001142628.1 NM_018144.3

Unigene Cluster for SEC61A2:

Sec61 alpha 2 subunit (S. cerevisiae)

Hs.112955 [show with all ESTs]

Unigene Representative Sequence: NM_018144

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379051 ENST00000441368 ENST00000475268(uc001ilh.4 uc001ilg.4)

ENST00000298428 ENST00000495368(uc001ilf.4) ENST00000304267 ENST00000472221

ENST00000379020 ENST00000379017 ENST00000457034 ENST00000418772 ENST00000419021

ENST00000466451 ENST00000426560 ENST00000379033(uc001ile.2 uc010qbq.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SEC61A2 Browse OriGene MicroRNA Expression Plasmids
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		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC61A2 (see all 43):
		hsa-miR-548j hsa-miR-429 hsa-miR-99b* hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-124 hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SEC61A2 3' UTR sequence

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Additional cDNA sequence:

AF346603.1 AK001440.1 AK022027.1 AK022640.1 AK057532.1 AK292295.1 AK301841.1 BC026179.1

NR_024576.1 NR_024577.1

17 DOTS entries:

DT.417545 DT.451643 DT.86852431 DT.97839588 DT.95373278 DT.215957 DT.97839587 DT.95080179

DT.95255517 DT.100697653 DT.102831352 DT.40121371 DT.100742830 DT.121284499 DT.121284697 DT.40271460

DT.91773611

24/119 AceView cDNA sequences (see all 119):

BX453009 BX453664 CR607709 AA918663 N91876 AA916221 AU120635 BX477824

AK022027 AK001440 AA322680 AW295825 AA644274 AI141531 BI823354 BF445225

AI792769 BG702843 AU150714 AA815300 AA876478 BU617299 AU128433 BG723109

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEC61A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGAAAAAAA

About this image

SEC61A2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Condyle

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEC61A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC61A2

SOURCE GeneReport for Unigene cluster: Hs.112955

SABiosciences Custom PCR Arrays for SEC61A2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC61A2 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC61A2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61A2 gene from 7/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sec61a2^{1 , 5}	Sec61, alpha subunit 2 (S. cerevisiae)^{1, 5}	90.48(n)¹ 100(a)¹		2 (3.62 cM)⁵ 57743¹ NM_021305.3¹ NP_067280.1¹ 5870987⁵
chicken (Gallus gallus)	Aves	SEC61A2¹	Sec61 alpha 2 subunit (S. cerevisiae)	85.15(n) 99.58(a)		426369 XM_424024.3 XP_424024.3
zebrafish (Danio rerio)	Actinopterygii	sec61al1⁶ sec61al2⁶	Sec61 alpha like 2	95(a) 93(a)	many ↔ many many ↔ many	6(39996075-40002769) 6(42309321-42320018)
fruit fly (Drosophila melanogaster)	Insecta	Sec61alpha¹	CG9539-PA	74.93(n) 91.18(a)		33905 NM_135190.4 NP_609034.1
worm (Caenorhabditis elegans)	Secernentea	CELE_Y57G11C.15¹	Protein Y57G11C.15	71.88(n) 87.53(a)		178407 NM_070392.6 NP_502793.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G78720¹	protein transport protein SEC61 subunit alpha	65.67(n) 70.36(a)		844208 NM_106519.1 NP_177993.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	protein transport protein Sec61 subunit alpha, put... protein transport protein Sec61 subunit alpha, put... (see all 10)	70(a) 69(a) (see all 10)	many ↔ many many ↔ many (see all 10)	3(5895033-5898530) 9(10905211-10907525)

ENSEMBL Gene Tree for SEC61A2 (if available)
TreeFam Gene Tree for SEC61A2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEC61A2 gene

SEC61A1²

1 SIMAP similar gene for SEC61A2 using alignment to 12 protein entries: S61A2_HUMAN (see all proteins):

SEC61A1

SEC61A2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9794069^1,2	C,H	--	12169659(+)	`CCTGAC/AAAGCT`	5	--	us2k¹		12		NA WA CSA	257
rs9794070^1,2	C,F,A	--	12169669(+)	`TGGGAC/AAACAG`	5	--	us2k¹		12		NA WA CSA EA	376
rs142866614^1,2		--	12169677(+)	`CAGGCA/GCAAAC`	5	--	us2k¹		0	--	--	--	--
rs188436369^1,2		--	12169805(+)	`GCTCAA/TAATTG`	5	--	us2k¹		0	--	--	--	--
rs143993879^1,2		--	12170042(+)	`CCCAC-/ATGTTCT`	5	--	us2k¹		0	--	--	--	--
rs75527722^1,2	F	--	12170129(+)	`TAAAAG/TATGCT`	5	--	us2k¹		1		WA	118
rs6602563^1,2	C,F,A,H	--	12170174(+)	`TGCCAT/CGCTGT`	5	--	us2k¹		25		NS EA NA WA CSA	2351
rs61188089^1,2	C,F	--	12170195(+)	`AGGCCG/ACTTGG`	5	--	us2k¹		2		WA EA	238
rs145038362^1,2		--	12170212(+)	`CATCTA/GGAGGT`	5	--	us2k¹		0	--	--	--	--
rs116432696^1,2	C,F	--	12170232(+)	`GACACC/GAGCAC`	5	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for SEC61A2 (12171636 - 12211960 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEC61A2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SEC61A2 for disorders About GeneDecksing

3 diseases for SEC61A2: About MalaCards

cholera alzheimer's disease malaria

Human Genome Epidemiology (HuGE) Navigator: SEC61A2 (1 document)

Export disorders for SEC61A2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEC61A2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with SEC61A2)

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world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Network organization of the human autophagy system. (PubMed id 20562859)¹ Behrends C....Harper J.W. (2010)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Functional annotation of a full-length mouse cDNA collection. (PubMed id 11217851)¹ Kawai J....Hayashizaki Y. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55176	HGNC: 17702	AceView: SEC61A2	Ensembl:ENSG00000065665	euGenes: HUgn55176
ECgene: SEC61A2	Kegg: 55176	H-InvDB: SEC61A2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEC61A2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEC61A2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEC61A2 gene:
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GeneCards and IP:
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SEC61A2 Gene

Sec61 alpha 2 subunit (S. cerevisiae)

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SEC61A2 Gene

Sec61 alpha 2 subunit (S. cerevisiae)

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