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Aliases for SEC61A2 Gene

Aliases for SEC61A2 Gene

  • Sec61 Alpha 2 Subunit (S. Cerevisiae) 2 3
  • Sec61 Alpha-2 4

External Ids for SEC61A2 Gene

Summaries for SEC61A2 Gene

Entrez Gene Summary for SEC61A2 Gene

  • The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for SEC61A2 Gene

SEC61A2 (Sec61 Alpha 2 Subunit (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A1.

UniProtKB/Swiss-Prot for SEC61A2 Gene

  • Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61A2 Gene

Genomics for SEC61A2 Gene

Genomic Location for SEC61A2 Gene

Start:
12,129,637 bp from pter
End:
12,169,961 bp from pter
Size:
40,325 bases
Orientation:
Plus strand

Genomic View for SEC61A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC61A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61A2 Gene

Regulatory Elements for SEC61A2 Gene

Proteins for SEC61A2 Gene

  • Protein details for SEC61A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9S3-S61A2_HUMAN
    Recommended name:
    Protein transport protein Sec61 subunit alpha isoform 2
    Protein Accession:
    Q9H9S3
    Secondary Accessions:
    • A8K8D0
    • B4DX72
    • F8W773

    Protein attributes for SEC61A2 Gene

    Size:
    476 amino acids
    Molecular mass:
    52248 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

    Alternative splice isoforms for SEC61A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC61A2 Gene

Proteomics data for SEC61A2 Gene at MOPED

Post-translational modifications for SEC61A2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys4, Lys107, Lys388, Lys392, and Lys395

No data available for DME Specific Peptides for SEC61A2 Gene

Domains for SEC61A2 Gene

Protein Domains for SEC61A2 Gene

UniProtKB/Swiss-Prot:

S61A2_HUMAN
Family:
  • Belongs to the SecY/SEC61-alpha family.:
    • Q9H9S3
genes like me logo Genes that share domains with SEC61A2: view

No data available for Gene Families for SEC61A2 Gene

Function for SEC61A2 Gene

Molecular function for SEC61A2 Gene

UniProtKB/Swiss-Prot Function: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).

Gene Ontology (GO) - Molecular Function for SEC61A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with SEC61A2: view

Phenotypes for SEC61A2 Gene

GenomeRNAi human phenotypes for SEC61A2:
genes like me logo Genes that share phenotypes with SEC61A2: view

miRNA for SEC61A2 Gene

miRTarBase miRNAs that target SEC61A2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC61A2 Gene

Localization for SEC61A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61A2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC61A2 Gene COMPARTMENTS Subcellular localization image for SEC61A2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SEC61A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC61A2: view

Pathways for SEC61A2 Gene

genes like me logo Genes that share pathways with SEC61A2: view

Gene Ontology (GO) - Biological Process for SEC61A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
genes like me logo Genes that share ontologies with SEC61A2: view

Transcripts for SEC61A2 Gene

Unigene Clusters for SEC61A2 Gene

Sec61 alpha 2 subunit (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61A2 Gene

No ASD Table

Relevant External Links for SEC61A2 Gene

GeneLoc Exon Structure for
SEC61A2
ECgene alternative splicing isoforms for
SEC61A2

Expression for SEC61A2 Gene

mRNA expression in normal human tissues for SEC61A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC61A2 Gene

SOURCE GeneReport for Unigene cluster for SEC61A2 Gene Hs.112955

genes like me logo Genes that share expressions with SEC61A2: view

Orthologs for SEC61A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC61A2 36
  • 99.3 (n)
  • 100 (a)
SEC61A2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC61A2 36
  • 92.86 (n)
  • 100 (a)
SEC61A2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC61A2 36
  • 92.69 (n)
  • 100 (a)
SEC61A2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec61a2 36
  • 90.48 (n)
  • 100 (a)
Sec61a2 16
Sec61a2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC61A2 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC61A2 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec61a2 36
  • 90.34 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SEC61A2 36
  • 85.05 (n)
  • 99.37 (a)
SEC61A2 37
  • 100 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009182 36
  • 72.86 (n)
  • 91.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sec61alpha 36
  • 74.93 (n)
  • 91.18 (a)
Sec61alpha 37
  • 91 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.15 36
  • 71.88 (n)
  • 87.53 (a)
sec-61 37
  • 87 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC61 37
  • 54 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.2468 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G78720 36
  • 65.67 (n)
  • 70.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4836 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11324 37
  • 80 (a)
OneToMany
Species with no ortholog for SEC61A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SEC61A2 Gene

ENSEMBL:
Gene Tree for SEC61A2 (if available)
TreeFam:
Gene Tree for SEC61A2 (if available)

Paralogs for SEC61A2 Gene

Paralogs for SEC61A2 Gene

Selected SIMAP similar genes for SEC61A2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SEC61A2: view

Variants for SEC61A2 Gene

Sequence variations from dbSNP and Humsavar for SEC61A2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11972 -- 12,165,509(+) ATCCT(A/G)AATTA intron-variant, downstream-variant-500B
rs876089 -- 12,164,194(-) CAGGT(A/C/T)GAGGC intron-variant
rs1053403 -- 12,166,308(-) CAAAG(C/T)TCTAA intron-variant
rs1053408 -- 12,165,041(-) ggagg(A/C)ggCCT intron-variant, utr-variant-3-prime
rs1573986 -- 12,161,322(+) agccc(A/G)tggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC61A2 Gene

Variant ID Type Subtype PubMed ID
esv2733095 CNV Deletion 23290073
esv2675175 CNV Deletion 23128226
nsv5820 CNV Insertion 18451855

Relevant External Links for SEC61A2 Gene

HapMap Linkage Disequilibrium report
SEC61A2

Disorders for SEC61A2 Gene

Relevant External Links for SEC61A2

Genetic Association Database (GAD)
SEC61A2
Human Genome Epidemiology (HuGE) Navigator
SEC61A2
genes like me logo Genes that share disorders with SEC61A2: view

No data available for UniProtKB/Swiss-Prot for SEC61A2 Gene

Publications for SEC61A2 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex. (PMID: 9565615) Chen Y. … Chuck S.L. (J. Biol. Chem. 1998) 3
  5. The role of assembly in insulin's biosynthesis. (PMID: 9631292) Dodson G. … Steiner D. (Curr. Opin. Struct. Biol. 1998) 3

Products for SEC61A2 Gene

Sources for SEC61A2 Gene

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