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Aliases for SEC61A1 Gene

Aliases for SEC61A1 Gene

  • Sec61 Translocon Alpha 1 Subunit 2 3 5
  • Sec61 Alpha-1 3 4
  • SEC61A 3 4
  • Protein Transport Protein SEC61 Alpha Subunit 3
  • Protein Transport Protein Sec61 Subunit Alpha 3
  • Sec61 Alpha 1 Subunit (S. Cerevisiae) 2
  • Sec61 Alpha 1 Subunit 3
  • Sec61 Homolog 3
  • HSEC61 3
  • SEC61 3

External Ids for SEC61A1 Gene

Previous GeneCards Identifiers for SEC61A1 Gene

  • GC03P124603
  • GC03P127954
  • GC00U912982
  • GC03P129092
  • GC03P129253
  • GC03P127770
  • GC03P125151

Summaries for SEC61A1 Gene

Entrez Gene Summary for SEC61A1 Gene

  • The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC61A1 Gene

SEC61A1 (Sec61 Translocon Alpha 1 Subunit) is a Protein Coding gene. Among its related pathways are Protein export and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A2.

UniProtKB/Swiss-Prot for SEC61A1 Gene

  • Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.

Gene Wiki entry for SEC61A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61A1 Gene

Genomics for SEC61A1 Gene

Regulatory Elements for SEC61A1 Gene

Enhancers for SEC61A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEC61A1 on UCSC Golden Path with GeneCards custom track

Promoters for SEC61A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC61A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC61A1 Gene

Chromosome:
3
Start:
128,051,641 bp from pter
End:
128,071,683 bp from pter
Size:
20,043 bases
Orientation:
Plus strand

Genomic View for SEC61A1 Gene

Genes around SEC61A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC61A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC61A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61A1 Gene

Proteins for SEC61A1 Gene

  • Protein details for SEC61A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61619-S61A1_HUMAN
    Recommended name:
    Protein transport protein Sec61 subunit alpha isoform 1
    Protein Accession:
    P61619
    Secondary Accessions:
    • P38378
    • P57726
    • Q5JPF8
    • Q8N0Z4
    • Q8N3U3
    • Q8NC71
    • Q9BU16
    • Q9Y2R3

    Protein attributes for SEC61A1 Gene

    Size:
    476 amino acids
    Molecular mass:
    52265 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
    SequenceCaution:
    • Sequence=BAC11283.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11434.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEC61A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC61A1 Gene

Proteomics data for SEC61A1 Gene at MOPED

Post-translational modifications for SEC61A1 Gene

  • Ubiquitination at Lys 4 and Lys 21
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC61A1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SEC61A1 (SEC61A1)

No data available for DME Specific Peptides for SEC61A1 Gene

Domains & Families for SEC61A1 Gene

Protein Domains for SEC61A1 Gene

Graphical View of Domain Structure for InterPro Entry

P61619

UniProtKB/Swiss-Prot:

S61A1_HUMAN :
  • Belongs to the SecY/SEC61-alpha family.
Family:
  • Belongs to the SecY/SEC61-alpha family.
genes like me logo Genes that share domains with SEC61A1: view

No data available for Gene Families for SEC61A1 Gene

Function for SEC61A1 Gene

Molecular function for SEC61A1 Gene

UniProtKB/Swiss-Prot Function:
Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.
genes like me logo Genes that share phenotypes with SEC61A1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC61A1 Gene

Localization for SEC61A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61A1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC61A1 Gene COMPARTMENTS Subcellular localization image for SEC61A1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 2
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for SEC61A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SEC61A1: view

Pathways & Interactions for SEC61A1 Gene

genes like me logo Genes that share pathways with SEC61A1: view

Gene Ontology (GO) - Biological Process for SEC61A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IMP 22375059
GO:0006620 posttranslational protein targeting to membrane IMP 22375059
GO:0007029 endoplasmic reticulum organization IMP 22375059
GO:0015031 protein transport IEA --
GO:0016049 cell growth IMP 22375059
genes like me logo Genes that share ontologies with SEC61A1: view

No data available for SIGNOR curated interactions for SEC61A1 Gene

Drugs & Compounds for SEC61A1 Gene

No Compound Related Data Available

Transcripts for SEC61A1 Gene

Unigene Clusters for SEC61A1 Gene

Sec61 alpha 1 subunit (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61A1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: - - - - - - - - - - - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - - - - - - - - - - - - - -
SP12: - -
SP13: -
SP14:
SP15:
SP16:

ExUns: 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: - - - - - -
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for SEC61A1 Gene

GeneLoc Exon Structure for
SEC61A1
ECgene alternative splicing isoforms for
SEC61A1

Expression for SEC61A1 Gene

mRNA expression in normal human tissues for SEC61A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC61A1 Gene

This gene is overexpressed in Nasal epithelium (23.0) and Bone (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC61A1 Gene



SOURCE GeneReport for Unigene cluster for SEC61A1 Gene Hs.518236

genes like me logo Genes that share expression patterns with SEC61A1: view

Protein tissue co-expression partners for SEC61A1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC61A1 Gene

Orthologs for SEC61A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC61A1 35
  • 87.82 (n)
  • 99.37 (a)
SEC61A1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC61A1 35
  • 90.97 (n)
  • 99.79 (a)
SEC61A1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec61a1 35
  • 90.34 (n)
  • 100 (a)
Sec61a1 16
Sec61a1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC61A1 35
  • 99.58 (n)
  • 100 (a)
SEC61A1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec61a1 35
  • 89.99 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC61A1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC61A1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC61A1 35
  • 82.35 (n)
  • 99.16 (a)
SEC61A1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC61A1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec61a1 35
  • 80.46 (n)
  • 98.11 (a)
Str.5949 35
African clawed frog
(Xenopus laevis)
Amphibia sec61a1-prov 35
zebrafish
(Danio rerio)
Actinopterygii sec61a 35
sec61a1 35
  • 80.25 (n)
  • 96.85 (a)
sec61a1 36
  • 97 (a)
OneToMany
sec61al2 36
  • 96 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4091 35
fruit fly
(Drosophila melanogaster)
Insecta Sec61alpha 37
  • 88 (a)
Sec61alpha 36
  • 89 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y57G11C.15 37
  • 84 (a)
sec-61 36
  • 85 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR596W 35
  • 57.54 (n)
  • 57.11 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01145g 35
  • 57.81 (n)
  • 59.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC61 35
  • 57.15 (n)
  • 57.3 (a)
SEC61 36
  • 54 (a)
OneToMany
SEC61 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29310 35
  • 67.02 (n)
  • 69.16 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.569 35
barley
(Hordeum vulgare)
Liliopsida Hv.2104 35
rice
(Oryza sativa)
Liliopsida Os09g0347700 35
  • 66.6 (n)
  • 70.24 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.247 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08897 35
  • 63.84 (n)
  • 64.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec61 35
  • 57.91 (n)
  • 59.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11324 36
  • 79 (a)
OneToMany
Species with no ortholog for SEC61A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SEC61A1 Gene

ENSEMBL:
Gene Tree for SEC61A1 (if available)
TreeFam:
Gene Tree for SEC61A1 (if available)

Paralogs for SEC61A1 Gene

Paralogs for SEC61A1 Gene

(1) SIMAP similar genes for SEC61A1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SEC61A1 Gene

genes like me logo Genes that share paralogs with SEC61A1: view

Variants for SEC61A1 Gene

Sequence variations from dbSNP and Humsavar for SEC61A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1030655 -- 128,054,833(-) CCAAA(A/G)CCTCT intron-variant
rs759945 -- 128,061,239(-) TCTCA(C/T)TGCAT intron-variant
rs2304018 -- 128,060,463(-) CCCCA(C/T)GGACA intron-variant
rs2335771 -- 128,061,101(-) TTGCA(C/T)GACCA intron-variant
rs9820563 -- 128,062,028(+) CCCCA(A/G)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC61A1 Gene

Variant ID Type Subtype PubMed ID
nsv3991 CNV Insertion 18451855
esv2477995 CNV Insertion 19546169

Variation tolerance for SEC61A1 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SEC61A1 Gene

Disorders for SEC61A1 Gene

Relevant External Links for SEC61A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC61A1

No disorders were found for SEC61A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC61A1 Gene

Publications for SEC61A1 Gene

  1. Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome. (PMID: 18480044) Daniel C.J. … Skach W.R. (J. Biol. Chem. 2008) 2 3 67
  2. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. (PMID: 10212142) Greenfield J.J. … High S. (J. Cell. Sci. 1999) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for SEC61A1 Gene

Sources for SEC61A1 Gene

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