SEC61A1 Gene
protein-coding GIFtS: 59
GCID: GC03P127770
|
|
Sec61 alpha 1 subunit (S. cerevisiae)
| |
Aliases
for SEC61A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sec61 Alpha 1 Subunit (S. Cerevisiae)1 2 | | Protein Transport Protein SEC61 Alpha Subunit2 | | SEC61A2 3 | | Protein Transport Protein Sec61 Subunit Alpha2 | | Sec61 Alpha-12 3 | | Protein Transport Protein Sec61 Subunit Alpha Isoform 12 | | HSEC612 | | Sec61 Homolog2 | | SEC612 | | |
Export aliases for SEC61A1 gene to outside databasesPrevious GC identifers: GC03P124603 GC03P127954 GC00U912982 GC03P129092 GC03P129253 GC03P125151 |
Summaries
for SEC61A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEC61A1:
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in theinsertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightlyassociated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alphasubunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: S61A1_HUMAN, P61619Function: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required forassembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly orthrough adapter proteins
Gene Wiki entry for SEC61A1 (Sec61 alpha 1)
|
Genomic Views
for SEC61A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEC61A1 gene promoter:
STAT1 AP-1 STAT1beta STAT1alpha c-Ets-1 PPAR-gamma1 POU2F1 GATA-6 POU2F1a PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEC61A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC61A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.3SEC61A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P127770: view genomic region
(about GC identifiers)
Start:
|
127,770,484 bp from pter |
End:
|
127,790,526 bp from pter |
Size:
|
20,043 bases |
Orientation:
|
plus strand |
|
Proteins
for SEC61A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S61A1_HUMAN, P61619 (See
protein sequence)Recommended Name: Protein transport protein Sec61 subunit alpha isoform 1 Size: 476 amino acids; 52265 Da
Subunit: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC11283.1; Type=Erroneous initiation; Sequence=BAC11434.1; Type=Erroneous initiation;
Secondary accessions: P38378 P57726 Q5JPF8 Q8N0Z4 Q8N3U3 Q8NC71 Q9BU16 Q9Y2R3Alternative splicing: 2 isoforms: P61619-1 P61619-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SEC61A1: NX_P61619
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P61619
SEC61A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037468.1
ENSEMBL proteins: ENSP00000418493 ENSP00000243253 ENSP00000419172 ENSP00000411445 Reactome Protein details: P61619
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SEC61A1 for ontologies About GeneDecksing
SEC61A1 Antibody Products:
Assay Products for SEC61A1: |
Protein
Domains /
Families
for SEC61A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEC61A1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P61619ProtoNet protein and cluster: P61619 1 Blocks protein family: IPB002208 SecY protein
UniProtKB/Swiss-Prot: S61A1_HUMAN, P61619Similarity: Belongs to the SecY/SEC61-alpha family |
Function
for SEC61A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S61A1_HUMAN, P61619Function: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required forassembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly orthrough adapter proteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SEC61A1 (NM_013336) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC61A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC61A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC61A1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity |
-- | -- | | GO:0043022 | ribosome binding |
ISS | -- |
SEC61A1 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for SEC61A1:
Animal Models:
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sec61a1):
SEC61A1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SEC61A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of degradation of wt-CFTR | | | 2 | Immune System | | | 3 | Immune response Antigen presentation by MHC class I | | | 4 | Synthesis of PB1-F2 | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SEC61A1
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC61A1
3  GeneGo (Thomson Reuters) Pathways for SEC61A1
5/9 
Reactome Pathways for SEC61A1 (see all 9)
4 
Kegg Pathways (Kegg details for SEC61A1):
SEC61A1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC61A1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/163 Interacting proteins for SEC61A1 (P616192, 3 ENSP000002432534) via UniProtKB, MINT, STRING, and/or I2D (see all 163)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
TAS | -- | | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS | -- | | GO:0034341 | response to interferon-gamma |
IEA | -- | | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I |
TAS | -- | | GO:0045047 | protein targeting to ER |
ISS | -- |
SEC61A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SEC61A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEC61A1
Search CenterWatch for drugs/clinical trials and news about SEC61A1 / S61A1
|
Transcripts
for SEC61A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEC61A1 gene: NM_013336.3 Unigene Cluster for SEC61A1: Sec61 alpha 1 subunit (S. cerevisiae) Hs.518236 [show with all ESTs]Unigene Representative Sequence: NM_0133367 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000464451 ENST00000243253(uc003ekb.3 uc003ekc.3) ENST00000481210
ENST00000491668 ENST00000424880(uc003ekd.3) ENST00000483956(uc003ekg.3)
ENST00000498837
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SEC61A1 (NM_013336) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC61A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC61A1 |
Additional cDNA sequence: AF077032.1 AF084458.1 AF346602.1 AK001689.1 AK027423.1 AK027452.1 AK027454.1 AK027458.1 AK074706.1 AK074907.1 AK074928.1 AK075148.1 AK129816.1 AK297239.1 AK299118.1 AL831940.1 AL832821.1 BC002951.1 BC029970.2 24/40 DOTS entries (see all 40): DT.100825925 DT.100825917 DT.100825907 DT.100825926 DT.308502 DT.95087490 DT.101985437 DT.120891393 DT.95173569 DT.120891460 DT.97821681 DT.97855940 DT.120891343 DT.120891250 DT.120891290 DT.120891450 DT.86840489 DT.95173560 DT.95173572 DT.95173581 DT.102838773 DT.120891181 DT.120891441 DT.91774520 24/1041 AceView cDNA sequences (see all 1041): AI365330 BM792241 BU627378 CA431199 T07978 BM854051 BU174120 BM827184 BM824194 BQ919179 AK129816 CF541126 BM824478 BQ013313 CA432040 BG165475 BQ677694 AI290587 BM823794 BF059753 BQ683476 BQ437715 AW139691 AI457304
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for SEC61A1 (see all 16) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | |
| ExUns: | 14b | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SEC61A1
|
Expression
for SEC61A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEC61A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCTCCCAC
About this image
See SEC61A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC61A1
SOURCE GeneReport for Unigene cluster: Hs.518236
SABiosciences Custom PCR Arrays for SEC61A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC61A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC61A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC61A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC61A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC61A1 |
Orthologs
for SEC61A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SEC61A1 gene from 9/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SEC61A11 |
Sec61 alpha 1 subunit (S. cerevisiae) |
82.42(n)
99.37(a) |
|
416023 XM_414364.2 XP_414364.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SEC61A16 |
-- |
98(a) |
1 ↔ 1 |
2(165734457-165746430) |
African clawed frog
(Xenopus laevis) |
Amphibia |
sec61a1-prov2 |
protein transport protein SEC61 alpha subunit isoform more |
80.46(n) |
|
BC045117.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
sec61a2 |
SEC61, alpha subunit |
76.25(n) |
|
192298 AY029527.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sec61alpha3 |
SRP-dependent, co-translational membrane
targeting, more |
88(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y57G11C.153 |
protein transport protein SEC61 alpha
subunit |
84(a) |
|
IV(14823001-14825012) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SEC61(YLR378C)4
SEC611 |
Essential subunit of Sec61 complex (Sec61p, Sbh1p, more4
Sec61p1 |
57.15(n)1
57.3(a)1 |
|
12(877178-875736)4
8510951, 4 NP_013482.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G293101 |
SecY protein transport family protein |
67.02(n)
69.16(a) |
|
839805 NM_102671.4 NP_174225.2 |
rice
(Oryza sativa) |
Liliopsida |
AK073633.12 |
-- |
74.46(n) |
|
AK073633.1 |
ENSEMBL Gene Tree for SEC61A1 (if available)
TreeFam Gene Tree for SEC61A1 (if available) |
Paralogs
for SEC61A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEC61A1 gene
- SEC61A22
1 SIMAP similar gene for SEC61A1 using alignment to 4 protein entries: S61A1_HUMAN (see all proteins):SEC61A2
SEC61A1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SEC61A1
PGOHUM00000232988
|
Genomic Variants
for SEC61A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEC61A1 (127770484 - 127790526 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEC61A1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC61A1 |
|
Disorders
/ Diseases
for SEC61A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SEC61A1 for disorders About GeneDecksing
OMIM gene information: 609213
OMIM disorders: --
6  diseases for SEC61A1: About MalaCardssecretory diarrhea cystic fibrosis diarrhea cholera
fibrosis malaria
Export disorders for SEC61A1 gene to outside databases
|
Publications
for SEC61A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEC61A1 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with SEC61A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. (PubMed id 22796945)1 Schauble N....Zimmermann R. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Different effects of Sec61a, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. (PubMed id 22375059)1 Lang S....Dudek J. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Interaction of calmodulin with Sec61I+ limits Ca2+ lea kage from the endoplasmic reticulum. (PubMed id 21102557)1 Erdmann F....Zimmermann R. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for SEC61A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SEC61A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SEC61A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SEC61A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SEC61A1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SEC61A1 gene:
Search GeneIP for patents involving SEC61A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SEC61A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for SEC61A1 | | OriGene shRNA RFP for SEC61A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC61A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC61A1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SEC61A1 | | OriGene 3'-UTR Clone for SEC61A1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC61A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SEC61A1 | | OriGene Custom Protein Services for SEC61A1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC61A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC61A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC61A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC61A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC61A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC61A1 |
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| | | | Search Tocris compounds for SEC61A1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC61A1 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC61A1 |
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