Aliases for SEC61A1 Gene
External Ids for SEC61A1 Gene
Previous GeneCards Identifiers for SEC61A1 Gene
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEC61A1 Gene
SEC61A1 (Sec61 Translocon Alpha 1 Subunit) is a Protein Coding gene. Diseases associated with SEC61A1 include Hyperuricemic Nephropathy, Familial Juvenile, 4. Among its related pathways are Innate Immune System and Gene Expression. Gene Ontology (GO) annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A2.
UniProtKB/Swiss-Prot for SEC61A1 Gene
Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins. Plays a role in pronephric kidney tubule development (By similarity).