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Aliases for SEC61A1 Gene

Aliases for SEC61A1 Gene

  • Sec61 Alpha 1 Subunit (S. Cerevisiae) 2 3
  • Sec61 Alpha-1 3 4
  • SEC61A 3 4
  • Protein Transport Protein Sec61 Subunit Alpha Isoform 1 3
  • Protein Transport Protein SEC61 Alpha Subunit 3
  • Protein Transport Protein Sec61 Subunit Alpha 3
  • Sec61 Homolog 3
  • HSEC61 3
  • SEC61 3

External Ids for SEC61A1 Gene

Previous GeneCards Identifiers for SEC61A1 Gene

  • GC03P124603
  • GC03P127954
  • GC00U912982
  • GC03P129092
  • GC03P129253
  • GC03P127770
  • GC03P125151

Summaries for SEC61A1 Gene

Entrez Gene Summary for SEC61A1 Gene

  • The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC61A1 Gene

SEC61A1 (Sec61 Alpha 1 Subunit (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with SEC61A1 include polycystic liver disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A2.

UniProtKB/Swiss-Prot for SEC61A1 Gene

  • Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins

Gene Wiki entry for SEC61A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC61A1 Gene

Genomics for SEC61A1 Gene

Regulatory Elements for SEC61A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC61A1 Gene

Start:
128,051,641 bp from pter
End:
128,071,683 bp from pter
Size:
20,043 bases
Orientation:
Plus strand

Genomic View for SEC61A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC61A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC61A1 Gene

Proteins for SEC61A1 Gene

  • Protein details for SEC61A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61619-S61A1_HUMAN
    Recommended name:
    Protein transport protein Sec61 subunit alpha isoform 1
    Protein Accession:
    P61619
    Secondary Accessions:
    • P38378
    • P57726
    • Q5JPF8
    • Q8N0Z4
    • Q8N3U3
    • Q8NC71
    • Q9BU16
    • Q9Y2R3

    Protein attributes for SEC61A1 Gene

    Size:
    476 amino acids
    Molecular mass:
    52265 Da
    Quaternary structure:
    • Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma
    SequenceCaution:
    • Sequence=BAC11283.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11434.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEC61A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC61A1 Gene

Proteomics data for SEC61A1 Gene at MOPED

Post-translational modifications for SEC61A1 Gene

  • Ubiquitination at Lys4, Lys10, Lys21, Lys107, Lys388, Lys392, and Lys395
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC61A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC61A1 Gene

Domains for SEC61A1 Gene

Protein Domains for SEC61A1 Gene

Graphical View of Domain Structure for InterPro Entry

P61619

UniProtKB/Swiss-Prot:

S61A1_HUMAN :
  • P61619
Family:
  • Belongs to the SecY/SEC61-alpha family.
genes like me logo Genes that share domains with SEC61A1: view

No data available for Gene Families for SEC61A1 Gene

Function for SEC61A1 Gene

Molecular function for SEC61A1 Gene

UniProtKB/Swiss-Prot Function: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins

Gene Ontology (GO) - Molecular Function for SEC61A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22314232
GO:0043022 ribosome binding ISS --
genes like me logo Genes that share ontologies with SEC61A1: view
genes like me logo Genes that share phenotypes with SEC61A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC61A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC61A1 Gene

Localization for SEC61A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC61A1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC61A1 Gene COMPARTMENTS Subcellular localization image for SEC61A1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
plasma membrane 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC61A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
GO:0016021 integral component of membrane --
GO:0030176 integral component of endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with SEC61A1: view

Pathways for SEC61A1 Gene

genes like me logo Genes that share pathways with SEC61A1: view

Gene Ontology (GO) - Biological Process for SEC61A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IMP 22375059
GO:0006620 posttranslational protein targeting to membrane IMP 22375059
GO:0007029 endoplasmic reticulum organization IMP 22375059
genes like me logo Genes that share ontologies with SEC61A1: view

Transcripts for SEC61A1 Gene

Unigene Clusters for SEC61A1 Gene

Sec61 alpha 1 subunit (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC61A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC61A1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: - - - - - - - - - - - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - - - - - - - - - - - - - -
SP12: - -
SP13: -
SP14:
SP15:
SP16:

ExUns: 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: - - - - - -
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for SEC61A1 Gene

GeneLoc Exon Structure for
SEC61A1
ECgene alternative splicing isoforms for
SEC61A1

Expression for SEC61A1 Gene

mRNA expression in normal human tissues for SEC61A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC61A1 Gene

SOURCE GeneReport for Unigene cluster for SEC61A1 Gene Hs.518236

genes like me logo Genes that share expressions with SEC61A1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC61A1 Gene

Orthologs for SEC61A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC61A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC61A1 35
  • 99.58 (n)
  • 100 (a)
SEC61A1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC61A1 35
  • 87.82 (n)
  • 99.37 (a)
SEC61A1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC61A1 35
  • 90.97 (n)
  • 99.79 (a)
SEC61A1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec61a1 35
  • 90.34 (n)
  • 100 (a)
Sec61a1 16
Sec61a1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC61A1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC61A1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec61a1 35
  • 89.99 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SEC61A1 35
  • 82.35 (n)
  • 99.16 (a)
SEC61A1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC61A1 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sec61a1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sec61a1 35
  • 80.46 (n)
  • 98.11 (a)
Str.5949 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4091 35
zebrafish
(Danio rerio)
Actinopterygii sec61a 35
sec61a1 35
  • 80.25 (n)
  • 96.85 (a)
sec61a1 36
  • 97 (a)
OneToMany
sec61al2 36
  • 96 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sec61alpha 36
  • 89 (a)
OneToMany
Sec61alpha 37
  • 88 (a)
worm
(Caenorhabditis elegans)
Secernentea sec-61 36
  • 85 (a)
OneToMany
Y57G11C.15 37
  • 84 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR596W 35
  • 57.54 (n)
  • 57.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC61 35
  • 57.15 (n)
  • 57.3 (a)
SEC61 36
  • 54 (a)
OneToMany
SEC61 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01145g 35
  • 57.81 (n)
  • 59.61 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.569 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29310 35
  • 67.02 (n)
  • 69.16 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2104 35
rice
(Oryza sativa)
Liliopsida Os09g0347700 35
  • 66.6 (n)
  • 70.24 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.247 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08897 35
  • 63.84 (n)
  • 64.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec61 35
  • 57.91 (n)
  • 59.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11324 36
  • 79 (a)
OneToMany
Species with no ortholog for SEC61A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SEC61A1 Gene

ENSEMBL:
Gene Tree for SEC61A1 (if available)
TreeFam:
Gene Tree for SEC61A1 (if available)

Paralogs for SEC61A1 Gene

Paralogs for SEC61A1 Gene

Selected SIMAP similar genes for SEC61A1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SEC61A1 Gene

genes like me logo Genes that share paralogs with SEC61A1: view

Variants for SEC61A1 Gene

Sequence variations from dbSNP and Humsavar for SEC61A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs759945 -- 128,061,239(-) TCTCA(C/T)TGCAT intron-variant
rs1030655 -- 128,054,833(-) CCAAA(A/G)CCTCT intron-variant
rs1030656 -- 128,054,784(-) TGCCT(C/G)TGAAA intron-variant
rs1042907 -- 128,070,329(+) CTTCT(C/G)GTTGG utr-variant-3-prime
rs1042911 -- 128,070,751(+) TGGTG(G/T)TGATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEC61A1 Gene

Variant ID Type Subtype PubMed ID
nsv3991 CNV Insertion 18451855
esv2477995 CNV Insertion 19546169

Relevant External Links for SEC61A1 Gene

HapMap Linkage Disequilibrium report
SEC61A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC61A1 Gene

Disorders for SEC61A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SEC61A1 Gene including...

Search for SEC61A1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SEC61A1 Gene

genes like me logo Genes that share disorders with SEC61A1: view

No data available for UniProtKB/Swiss-Prot for SEC61A1 Gene

Publications for SEC61A1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  3. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PMID: 17110338) Wang X. … Balch W.E. (Cell 2006) 3

Products for SEC61A1 Gene

Sources for SEC61A1 Gene

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