Aliases for SEC61A1 Gene
External Ids for SEC61A1 Gene
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEC61A1 Gene
SEC61A1 (Sec61 Alpha 1 Subunit (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with SEC61A1 include polycystic liver disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include ribosome binding. An important paralog of this gene is SEC61A2.
UniProtKB/Swiss-Prot for SEC61A1 Gene
Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins