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Aliases for SEC31B Gene

Aliases for SEC31B Gene

  • SEC31 Homolog B, COPII Coat Complex Component 2 3 5
  • SEC31-Related Protein B 3 4
  • SEC31-Like Protein 2 3 4
  • SEC31B-1 3 4
  • SEC31L2 3 4
  • SEC31 Homolog B, COPII Coating Complex Component 3
  • Secretory Pathway Component Sec31B-1 3
  • Protein Transport Protein Sec31B 3
  • SEC31 Homolog B (S. Cerevisiae) 2
  • SEC31-Like 2 (S. Cerevisiae) 2
  • SEC31-Like 2 3

External Ids for SEC31B Gene

Previous HGNC Symbols for SEC31B Gene

  • SEC31L2

Previous GeneCards Identifiers for SEC31B Gene

  • GC10M102237
  • GC10M095875

Summaries for SEC31B Gene

Entrez Gene Summary for SEC31B Gene

  • This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC31B Gene

SEC31B (SEC31 Homolog B, COPII Coat Complex Component) is a Protein Coding gene. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Protein processing in endoplasmic reticulum. An important paralog of this gene is SEC31A.

UniProtKB/Swiss-Prot for SEC31B Gene

  • As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.

Additional gene information for SEC31B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC31B Gene

Genomics for SEC31B Gene

GeneHancer (GH) Regulatory Elements for SEC31B Gene

Promoters and enhancers for SEC31B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I100518 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 589.9 +0.3 266 1.6 CTCF SAP130 ARID4B SIN3A ZNF48 RAD21 RFX5 ZNF664 GATAD1 SCRT2 SEC31B WNT8B BLOC1S2 CWF19L1 ENSG00000255339 GC10M100502 GC10M100501
GH10I100517 Enhancer 0.3 dbSUPER 550.8 +1.9 1857 0.6 ZNF189 SEC31B ENSG00000255339 GC10M100502 GC10M100501
GH10I100528 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 46.7 -9.5 -9457 2.5 PKNOX1 ATF1 ZFP64 SIN3A DMAP1 ZNF48 YY1 ETS1 POLR2B ZNF143 HIF1AN NDUFB8 ENSG00000255339 SEC31B
GH10I100535 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 39.8 -16.1 -16073 1.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B E2F8 HIF1AN SEC31B PHBP9 CWF19L1 SLC25A28 MRPL43 SLF2 SEMA4G NDUFB8 ENSG00000274660
GH10I100481 Enhancer 1.1 Ensembl ENCODE 57.9 +37.4 37439 2 CLOCK ATF1 ARID4B GLI4 ZNF2 BRCA1 ZNF48 ZNF121 GLIS2 ZNF143 SEC31B MRPL43 NDUFB8 ENSG00000255339 HIF1AN SLC25A28 LZTS2 LOC105378452 GC10M100500 WNT8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEC31B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC31B gene promoter:

Genomic Locations for SEC31B Gene

Genomic Locations for SEC31B Gene
33,223 bases
Minus strand

Genomic View for SEC31B Gene

Genes around SEC31B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC31B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC31B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC31B Gene

Proteins for SEC31B Gene

  • Protein details for SEC31B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein transport protein Sec31B
    Protein Accession:
    Secondary Accessions:
    • B7ZM75
    • Q6MZS3
    • Q86UF0
    • Q9Y4Q8

    Protein attributes for SEC31B Gene

    1179 amino acids
    Molecular mass:
    128697 Da
    Quaternary structure:
    • COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with SEC31A.

    Alternative splice isoforms for SEC31B Gene


neXtProt entry for SEC31B Gene

Post-translational modifications for SEC31B Gene

  • Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.

Other Protein References for SEC31B Gene

No data available for DME Specific Peptides for SEC31B Gene

Domains & Families for SEC31B Gene

Gene Families for SEC31B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat SEC31 family.
  • Belongs to the WD repeat SEC31 family.
genes like me logo Genes that share domains with SEC31B: view

Function for SEC31B Gene

Molecular function for SEC31B Gene

UniProtKB/Swiss-Prot Function:
As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.

Phenotypes From GWAS Catalog for SEC31B Gene

genes like me logo Genes that share phenotypes with SEC31B: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC31B Gene

Localization for SEC31B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC31B Gene

Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC31B gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEC31B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0012507 ER to Golgi transport vesicle membrane IEA --
GO:0016020 membrane IEA --
GO:0030120 vesicle coat IDA 22792322
genes like me logo Genes that share ontologies with SEC31B: view

Pathways & Interactions for SEC31B Gene

genes like me logo Genes that share pathways with SEC31B: view

Gene Ontology (GO) - Biological Process for SEC31B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SEC31B: view

No data available for SIGNOR curated interactions for SEC31B Gene

Drugs & Compounds for SEC31B Gene

No Compound Related Data Available

Transcripts for SEC31B Gene

Unigene Clusters for SEC31B Gene

SEC31 homolog B (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC31B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b · 15c ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: - - -
SP8: - -

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP7: - - -
SP9: - -
SP10: - -
SP13: -

ExUns: 29a · 29b

Relevant External Links for SEC31B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC31B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC31B Gene

Protein differential expression in normal tissues from HIPED for SEC31B Gene

This gene is overexpressed in Liver (59.4) and Heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEC31B Gene

Protein tissue co-expression partners for SEC31B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC31B Gene:


SOURCE GeneReport for Unigene cluster for SEC31B Gene:


mRNA Expression by UniProt/SwissProt for SEC31B Gene:

Tissue specificity: Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein level).

Evidence on tissue expression from TISSUES for SEC31B Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with SEC31B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC31B Gene

Orthologs for SEC31B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC31B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC31B 33 34
  • 97.04 (n)
(Bos Taurus)
Mammalia SEC31B 33 34
  • 87.71 (n)
(Canis familiaris)
Mammalia SEC31B 33 34
  • 87.52 (n)
(Rattus norvegicus)
Mammalia Sec31b 33
  • 83.19 (n)
(Mus musculus)
Mammalia Sec31b 33 16 34
  • 82.66 (n)
(Monodelphis domestica)
Mammalia SEC31B 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
-- 34
  • 56 (a)
(Gallus gallus)
Aves SEC31B 33 34
  • 65.3 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec31b 33
  • 60.58 (n)
(Danio rerio)
Actinopterygii sec31b 33 34
  • 58.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec31 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea sec-31 34
  • 22 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR090W 33
  • 43.91 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05159g 33
  • 43.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC31 33 34
  • 41.41 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G63460 33
  • 47 (n)
(Oryza sativa)
Liliopsida Os07g0657200 33
  • 44.59 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06738 33
  • 46.84 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec31 33
  • 41.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8708 34
  • 37 (a)
Species where no ortholog for SEC31B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC31B Gene

Gene Tree for SEC31B (if available)
Gene Tree for SEC31B (if available)

Paralogs for SEC31B Gene

Paralogs for SEC31B Gene

(1) SIMAP similar genes for SEC31B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SEC31B: view

Variants for SEC31B Gene

Sequence variations from dbSNP and Humsavar for SEC31B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000017998 -- 100,495,123(-) G/A intron_variant
rs1000088032 -- 100,493,649(-) C/ intron_variant
rs1000095580 -- 100,489,125(-) G/A intron_variant
rs1000161061 -- 100,488,490(-) T/C intron_variant
rs1000240469 -- 100,515,760(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC31B Gene

Variant ID Type Subtype PubMed ID
esv2759779 CNV gain+loss 17122850
esv34217 CNV gain 17911159
esv3624362 CNV gain 21293372
nsv1120227 CNV tandem duplication 24896259
nsv7519 CNV insertion 18451855
nsv818783 CNV gain 17921354
nsv831962 CNV gain 17160897
nsv831963 CNV loss 17160897
nsv8723 CNV gain 18304495

Variation tolerance for SEC31B Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.31; 98.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC31B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC31B Gene

Disorders for SEC31B Gene

Additional Disease Information for SEC31B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SEC31B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC31B Gene

Publications for SEC31B Gene

  1. Human Sec31B: a family of new mammalian orthologues of yeast Sec31p that associate with the COPII coat. (PMID: 16495487) Stankewich MC … Morrow JS (Journal of cell science 2006) 2 3 4 58
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  3. Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport. (PMID: 10788476) Tang BL … Hong W (The Journal of biological chemistry 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for SEC31B Gene

Sources for SEC31B Gene

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