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SEC31B Gene

protein-coding   GIFtS: 54
GCID: GC10M102237

SEC31 Homolog B (S. Cerevisiae)

(Previous name: SEC31-like 2 (S. cerevisiae))
(Previous symbol: SEC31L2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SEC31 Homolog B (S. Cerevisiae)1 2     SEC31-Like 2 (S. Cerevisiae)1
SEC31L21 2 3 5     Protein Transport Protein Sec31B2
SEC31B-12 3     SEC31-Like 22
SEC31-Like Protein 22 3     Secretory Pathway Component Sec31B-12
SEC31-Related Protein B2 3     

External Ids:    HGNC: 231971   Entrez Gene: 259562   Ensembl: ENSG000000758267   OMIM: 6102585   UniProtKB: Q9NQW13   

Export aliases for SEC31B gene to outside databases

Previous GC identifer: GC10M095875


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEC31B Gene:
This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is
an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II
phosphorylation site. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEC31B Gene:
SEC31B (SEC31 homolog B (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is SEC31A.

UniProtKB/Swiss-Prot: SC31B_HUMAN, Q9NQW1
Function: As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export
from the endoplasmic reticulum




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC31B gene promoter:
         SRF   RP58   SRF (504 AA)   MIF-1   CUTL1   Tal-1beta   Max   NF-Y   CBF(2)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC31B promoter sequence
   Search Chromatin IP Primers for SEC31B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC31B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.32

SEC31B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC31B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M102237:  view genomic region     (about GC identifiers)

Start:
102,246,399 bp from pter      End:
102,289,628 bp from pter
Size:
43,230 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SC31B_HUMAN, Q9NQW1 (See protein sequence)
Recommended Name: Protein transport protein Sec31B  
Size: 1179 amino acids; 128697 Da
Subunit: COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and
SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in
multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts
with SEC31A
Secondary accessions: B7ZM75 Q6MZS3 Q86UF0 Q9Y4Q8
Alternative splicing: 5 isoforms:  Q9NQW1-1   Q9NQW1-2   Q9NQW1-3   Q9NQW1-4   Q9NQW1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC31B: NX_Q9NQW1

Explore proteomics data for SEC31B at MOPED

Post-translational modifications: 

  • Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SEC31B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056305.1  
    ENSEMBL proteins: 
     ENSP00000359370   ENSP00000473995   ENSP00000474124   ENSP00000435359   ENSP00000432260  
     ENSP00000473769   ENSP00000391178   ENSP00000359354   ENSP00000442621  

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    Cloud-Clone Corp. Proteins for SEC31B

     
    Search eBioscience for Proteins for SEC31B 

     
    antibodies-online proteins for SEC31B (2 products) 

     
    Search antibodies-online for peptides for SEC31B

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    antibodies-online kits for SEC31B (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQW1

    ProtoNet protein and cluster: Q9NQW1

    UniProtKB/Swiss-Prot: SC31B_HUMAN, Q9NQW1
    Similarity: Belongs to the WD repeat SEC31 family
    Similarity: Contains 8 WD repeats


    Find genes that share domains with SEC31B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC31B_HUMAN, Q9NQW1
    Function: As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export
    from the endoplasmic reticulum

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SEC31B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SEC31B

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SEC31B (see all 22):
    hsa-miR-34b* hsa-miR-137 hsa-let-7d hsa-miR-25 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidSEC31B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC31B_HUMAN, Q9NQW1: Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein;
    Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0012507ER to Golgi transport vesicle membrane IEA--
    GO:0030120vesicle coat IDA--

    Find genes that share ontologies with SEC31B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEC31B About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.31
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with SEC31B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 GeneGo (Thomson Reuters) Pathways for SEC31B
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SEC31B
        SREBP signalling


    1 Kegg Pathway  (Kegg details for SEC31B):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC31B
    Interactions:

        Search GeneGlobe Interaction Network for SEC31B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC31B (Q9NQW12, 3 ENSP000003593704) via UniProtKB, MINT, STRING, and/or I2D (see all 629)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEC23BQ154372, ENSP000002625444MINT-7945693 STRING: ENSP00000262544
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    CCT6AP402272, ENSP000002756034MINT-7945693 STRING: ENSP00000275603
    CLP1Q929892, ENSP000003047044MINT-7945693 STRING: ENSP00000304704
    DDX17Q928412, ENSP000003800334MINT-7945693 STRING: ENSP00000380033
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--

    Find genes that share ontologies with SEC31B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC31B (SC31B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEC31B gene (2 alternative transcripts): 
    NM_015490.3  NM_198138.1  

    Unigene Cluster for SEC31B:

    SEC31 homolog B (S. cerevisiae)
    Hs.18889  [show with all ESTs]
    Unigene Representative Sequence: BC071580
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370345(uc010qpo.1 uc001krc.1) ENST00000485800 ENST00000492667
    ENST00000479697(uc001krd.1 uc001krf.1) ENST00000462434(uc001kre.1 uc010qpp.1 uc009xwn.1)
    ENST00000469546 ENST00000482456 ENST00000484848(uc001krg.1) ENST00000469824
    ENST00000498298 ENST00000494350 ENST00000490567 ENST00000480905 ENST00000451524
    ENST00000370329 ENST00000535773
    miRNA
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    hsa-miR-34b* hsa-miR-137 hsa-let-7d hsa-miR-25 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidSEC31B 3' UTR sequence
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    Additional mRNA sequence: 

    AF274863.1 AK128343.1 AK289975.1 AK294551.1 AL080141.1 BC034946.1 BC053949.1 BC071580.1 
    BC144312.1 BC144313.1 BX640914.1 

    18 DOTS entries:

    DT.414090  DT.100777583  DT.95144885  DT.101971667  DT.100023015  DT.92016427  DT.87011974  DT.97827424 
    DT.121302765  DT.100737571  DT.102835184  DT.121302720  DT.121302739  DT.91866804  DT.100882005  DT.121302789 
    DT.121302791  DT.92004038 

    Selected AceView cDNA sequences (see all 681):

    N51696 BQ422508 BM919847 BM888513 BM876468 BM988836 BM697067 BQ878253 
    AL080141 BM553550 CF127298 AI369318 BU624098 CF130051 BP378103 CD673094 
    CF130332 BM853119 CF129608 CF130331 CR592473 CK824041 BM314721 CF130641 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEC31B (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b · 15c ^
    SP1:              -                       -           -                       -                                                                             -   
    SP2:              -                                   -                       -                                                     -     -                 -   
    SP3:              -     -                             -                       -                                                     -                       -   
    SP4:                                      -           -                       -                                                     -                       -   
    SP5:                                                                    -     -                                                     -     -                 -   

    ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28 ^
    SP1:              -     -                             -                 -           -           -     -                       -                 -               
    SP2:              -     -                             -                 -           -           -     -                       -                 -               
    SP3:              -     -                             -                 -           -           -     -     -     -           -                 -               
    SP4:              -     -                             -                 -           -           -     -     -     -           -                 -               
    SP5:              -     -                             -                 -                                                                                       

    ExUns: 29a · 29b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SEC31B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SEC31B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEC31B Expression
    About this image

    SEC31B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC31B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18889

    UniProtKB/Swiss-Prot: SC31B_HUMAN, Q9NQW1
    Tissue specificity: Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed
    in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and
    granular cells (at protein level)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC31B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC31B gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec31b1 , 5 Sec31 homolog B (S. cerevisiae)1, 5 82.66(n)1
    79.57(a)1
      19 (37.98 cM)5
    2406671  NM_001033343.11  NP_001028515.11 
     445169575 
    chicken
    (Gallus gallus)
    Aves SEC31B1 SEC31 homolog B (S. cerevisiae) 65.3(n)
    59.74(a)
      423764  XM_001232875.3  XP_001232876.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sec31b1 SEC31 homolog B (S. cerevisiae) 60.58(n)
    57.53(a)
      100497536  XM_004915940.1  XP_004915997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sec31b1 Sec31 homolog B (S. cerevisiae) 58.82(n)
    53.46(a)
      100148383  XM_005173004.1  XP_005173061.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec316
    sec31
    30(a)
    1 → many
    2R(4781129-4786303)
    worm
    (Caenorhabditis elegans)
    Secernentea sec-316
    Protein SEC-31 (sec-31) mRNA, complete cds
    22(a)
    1 → many
    IV(11365618-11371792) WBGene00011338
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC311 SEC31 41.41(n)
    28.29(a)
      851332   NP_010086.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G634601 AT3G63460 47(n)
    37.02(a)
      825521  NM_180693.1  NP_851024.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06572001 Os07g0657200 44.59(n)
    34.44(a)
      4344154  NM_001067045.1  NP_001060510.1 


    ENSEMBL Gene Tree for SEC31B (if available)
    TreeFam Gene Tree for SEC31B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEC31B gene
    SEC31A2  
    1 SIMAP similar gene for SEC31B using alignment to 5 protein entries:     SC31B_HUMAN (see all proteins):
    SEC31A

    Find genes that share paralogs with SEC31B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEC31B (see all 819)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492126761,2
    --102246040(+) AGCCCG/TCAGAC 1 -- ds50010--------
    rs1876295661,2
    --102246079(+) TAGCAA/TCCCCT 1 -- ds50010--------
    rs94198971,2
    C,A,H--102246125(+) AGCCCT/CGAAGT 1 -- ds50016Minor allele frequency- C:0.20NA CSA WA EA 363
    rs1908491201,2
    --102246166(+) AGGCAC/TGGATG 1 -- ds50010--------
    rs1424825221,2
    --102246167(+) GGCACA/GGATGA 1 -- ds50010--------
    rs1834709661,2
    --102246335(+) GAATAA/GAGAGG 1 -- ds50010--------
    rs1877541081,2
    --102246372(+) CCCAGA/GGGAGG 1 -- ds50010--------
    rs753679211,2
    C,F--102246430(+) GCACCA/GTTAAG 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs29701,2
    C,F,O,A,H--102246512(+) GGCTGC/TGAGGG 1 -- ut31 ese323Minor allele frequency- T:0.28MN EA NS NA WA 4228
    rs1468446751,2
    --102246696(+) CACAGC/TCTAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SEC31B (102246399 - 102289628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SEC31B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7519CNV Insertion18451855
    nsv831963CNV Loss17160897
    dgv811n71CNV Loss21882294
    nsv895957CNV Gain21882294
    nsv818783CNV Gain17921354
    esv34217CNV Gain17911159
    nsv831962CNV Gain17160897
    nsv8723CNV Gain18304495
    essv24916CNV CNV17122850
    dgv318e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC31B
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC31B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610258    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SEC31B:
    Stomatitis

    Find genes that share disorders with SEC31B           About GenesLikeMe

    Genetic Association Database (GAD): SEC31B
    Human Genome Epidemiology (HuGE) Navigator: SEC31B (1 document)

    Export disorders for SEC31B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEC31B gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SEC31B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Sec31B: a family of new mammalian orthologues of yeast Sec31p that associate with the COPII coat. (PubMed id 16495487)1, 2, 3 Stankewich M.C.... Morrow J.S. (J. Cell Sci. 2006)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport. (PubMed id 10788476)1, 2 Tang B.L.... Hong W. (J. Biol. Chem. 2000)
    4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (Circ Cardiovasc Genet 2013)
    5. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
    6. Ubiquitin-dependent regulation of COPII coat size and function. (PubMed id 22358839)2 Jin L.... Rape M. (Nature 2012)
    7. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (Cell Cycle 2010)
    8. Composition and three-dimensional EM structure of double affinity- purified, human prespliceosomal A complexes. (PubMed id 17332742)1 Behzadnia N.... Luehrmann R. (EMBO J. 2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25956 HGNC: 23197 AceView: NDUFB8andSEC31L2 Ensembl:ENSG00000075826 euGenes: HUgn25956
    ECgene: SEC31B Kegg: 25956 H-InvDB: SEC31B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SEC31B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEC31B gene:
    Search GeneIP for patents involving SEC31B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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