SEC31A Gene
protein-coding GIFtS: 57
GCID: GC04M083739
|
|
SEC31 homolog A (S. cerevisiae)(Previous names: SEC31-like 1 (S. cerevisiae), Sec31 homolog A (S. cerevisiae)...)
(Previous symbol: SEC31L1)
| |
Aliases
for SEC31A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SEC31 Homolog A (S. Cerevisiae)1 2 | | SEC31-Like Protein 12 3 | | ABP1251 2 3 | | SEC31-Related Protein A2 3 | | ABP1301 2 3 | | SEC31-Like 1 (S. Cerevisiae)1 | | SEC31L11 2 3 | | HSPC3342 | | KIAA09051 3 | | Protein Transport Protein Sec31A2 | | Web1-Like Protein2 3 | | Yeast Sec31p Homolog2 |
Export aliases for SEC31A gene to outside databasesPrevious GC identifers: GC04M083958 GC04M079479 |
Summaries
for SEC31A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEC31A:
The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component ofthe COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein wasfound to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding tothe vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgitransport. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SC31A_HUMAN, O94979Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from theendoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulummembrane into vesicles and the selection of cargo molecules (By similarity)
Gene Wiki entry for SEC31A
|
Genomic Views
for SEC31A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEC31A gene promoter:
CBF-C AREB6 Max MZF-1 PPAR-gamma1 CBF-A CBF-B PPAR-gamma2 c-Myc CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEC31A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC31A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q21.22 Ensembl cytogenetic band: 4q21.22 HGNC cytogenetic band: 4q21.3SEC31A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M083739: view genomic region
(about GC identifiers)
Start:
|
83,739,814 bp from pter |
End:
|
83,822,319 bp from pter |
Size:
|
82,506 bases |
Orientation:
|
minus strand |
|
Proteins
for SEC31A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SC31A_HUMAN, O94979 (See
protein sequence)Recommended Name: Protein transport protein Sec31A Size: 1220 amino acids; 133015 Da
Subunit: COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiplecopies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6 ina calcium-dependent manner. Interacts with KLHL12
Subcellular location: Cytoplasm (By similarity). Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheralmembrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity).Note=Associates with membranes in a GTP-dependent manner (By similarity)
Sequence caution: Sequence=AAF28953.1; Type=Frameshift; Positions=857, 1079; Sequence=AAF29012.1; Type=Frameshift;Positions=922, 946, 1029, 1080; Sequence=CAI45995.1; Type=Erroneous termination; Positions=221; Note=Translated asTrp;
Secondary accessions: B4DIW6 B7ZKZ7 H7C2W3 Q17RR5 Q5H9P6 Q5XG74 Q659G7 Q6ZU90 Q7LCX9 Q86TJ0 Q8IZH4Q9P048 Q9P0A6 Q9UM05 Q9UM06Alternative splicing: 9 isoforms: O94979-1 O94979-2 O94979-3 O94979-4 O94979-5 O94979-6 O94979-7 O94979-8 O94979-9 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SEC31A: NX_O94979
Post-translational modifications:
Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94979
SEC31A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001070674.1 NP_001070675.1 NP_001070676.1 NP_001177978.1 NP_055748.2 NP_057295.2
ENSEMBL proteins: ENSP00000422371 ENSP00000337602 ENSP00000426886 ENSP00000378721 ENSP00000408027 ENSP00000426569 ENSP00000421633 ENSP00000421464 ENSP00000424635 ENSP00000347329 ENSP00000426943 ENSP00000264405 ENSP00000424451 ENSP00000425140 ENSP00000425999 ENSP00000426562 ENSP00000424336 ENSP00000422267 ENSP00000425056 ENSP00000421001 ENSP00000425555 ENSP00000426950 ENSP00000422797 ENSP00000422563 ENSP00000425095 ENSP00000425064 ENSP00000407944 ENSP00000400926 ENSP00000325087 ENSP00000309070 Reactome Protein details: O94979
Human Recombinant Protein Products for SEC31A:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
SEC31A for ontologies About GeneDecksing
SEC31A Antibody Products:
Assay Products for SEC31A: |
Protein
Domains /
Families
for SEC31A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEC31A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O94979ProtoNet protein and cluster: O94979 UniProtKB/Swiss-Prot: SC31A_HUMAN, O94979Similarity: Belongs to the WD repeat SEC31 familySimilarity: Contains 8 WD repeats |
Function
for SEC31A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SC31A_HUMAN, O94979Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from theendoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulummembrane into vesicles and the selection of cargo molecules (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SEC31A for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC31A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC31A (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): SEC31A (NM_016211) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC31A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC31A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC31A |
|
Pathways & Interactions
for SEC31A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | COPII (Coat Protein 2) Mediated Vesicle Transport | | | 2 | Clathrin-dependent protein traffic | | | 3 | Asparagine N-linked glycosylation | | | 4 | Activation of Chaperone Genes by XBP1(S) | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SEC31A
1 
Cell Signaling Technology (CST) Pathway for SEC31A
4  GeneGo (Thomson Reuters) Pathways for SEC31A
1  BioSystems Pathway for SEC31A
5/16 
Reactome Pathways for SEC31A (see all 16)
1 
Kegg Pathway (Kegg details for SEC31A):
SEC31A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEC31A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/134 Interacting proteins for SEC31A (O949791, 2, 3 ENSP000003473294) via UniProtKB, MINT, STRING, and/or I2D (see all 134)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
TAS | -- | | GO:0006888 | ER to Golgi vesicle-mediated transport |
TAS | -- | | GO:0006987 | activation of signaling protein activity involved in unfolded protein response |
TAS | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0016044 | cellular membrane organization |
TAS | -- |
SEC31A for ontologies About GeneDecksing
|
Drugs & Compounds
for SEC31A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEC31A
2 HMDB Compounds for SEC31A About this table
Search CenterWatch for drugs/clinical trials and news about SEC31A / SC31A
|
Transcripts
for SEC31A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEC31A gene (6 alternative transcripts): NM_001077206.2 NM_001077207.2 NM_001077208.2 NM_001191049.1 NM_014933.3 NM_016211.3 Unigene Cluster for SEC31A: SEC31 homolog A (S. cerevisiae) Hs.370024 [show with all ESTs]Unigene Representative Sequence: NM_01493318/43 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 43): ENST00000503937 ENST00000348405 ENST00000513858 ENST00000395310(uc003hnf.3 uc011ccn.2 uc011ccl.2 uc003hnl.3 uc003hng.3 uc011ccm.2 uc003hnh.3 uc003hni.3 uc003hnk.3)
ENST00000443462 ENST00000509142 ENST00000505472 ENST00000500777 ENST00000508502
ENST00000355196(uc003hnm.3) ENST00000515062 ENST00000264405(uc003hne.3)
ENST00000505479 ENST00000505984 ENST00000511338 ENST00000514362 ENST00000515749
ENST00000509691
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC31A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC31A (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): SEC31A (NM_016211) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC31A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC31A |
Additional cDNA sequence: AB018358.1 AB018359.1 AF139184.1 AF161393.1 AF161452.1 AK001014.1 AK225934.1 AK295810.1 AL049463.1 AY137583.1 BC031292.1 BC039834.1 BC047883.2 BC084583.1 BC117221.1 BC143489.1 BC143491.1 BC143492.2 CR933696.1 24/45 DOTS entries (see all 45): DT.95233055 DT.95179749 DT.95179771 DT.95302497 DT.95192148 DT.95179772 DT.100045598 DT.318707 DT.99983799 DT.95125557 DT.100883081 DT.95069249 DT.100883088 DT.101988033 DT.95179768 DT.100686311 DT.100883074 DT.100883076 DT.121263794 DT.40200796 DT.100883083 DT.121263755 DT.437578 DT.91768163 24/79 AceView cDNA sequences (see all 79): AA423899 AA232426 AA488663 CB528449 BF516091 BG390414 BE819473 CD109746 CD700779 BU429528 AA059442 BG938663 AW994510 CB269955 BQ890145 BG777014 AL575642 BU658156 BE742713 BF036212 BI544651 AA423860 AW068529 BI086333
GeneLoc Exon Structure
5/34 Alternative Splicing Database (ASD) splice patterns (SP) for SEC31A (see all 34) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ |
|---|
|
| SP1: | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP2: | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP3: | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP4: | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | |
| SP5: | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | |
| ExUns: | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | ^ | 33 | ^ | 34a | · | 34b | ^ | 35 | ^ | 36a | · | 36b | ^ | 37a | · | 37b | ^ | 38 | ^ | 39a | · | 39b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SEC31A
|
Expression
for SEC31A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEC31A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTCCCTAC
About this image
See SEC31A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC31A
SOURCE GeneReport for Unigene cluster: Hs.370024
UniProtKB/Swiss-Prot: SC31A_HUMAN, O94979Tissue specificity: Abundantly and ubiquitously expressed
SABiosciences Custom PCR Arrays for SEC31A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC31A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC31A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC31A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC31A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC31A |
Orthologs
for SEC31A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SEC31A gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SEC31A1 |
SEC31 homolog A (S. cerevisiae) |
74.35(n)
79.86(a) |
|
422597 NM_001031141.1 NP_001026312.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SEC31A6 |
-- |
78(a) |
1 ↔ 1 |
5(43083014-43126338) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.340772 |
Xenopus laevis transcribed sequence with weak similarity more |
78.19(n) |
|
BJ073036.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
sec31p2 |
sec31p homolog (yeast) |
75.43(n) |
|
266638 BC054909.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
sec311 |
CG8266-PA |
47.99(n)
39.63(a) |
|
35877 NM_165630.2 NP_724716.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
sec-316 |
-- |
18(a) |
possible ortholog |
IV(11365596-11371772) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SEC31(YDL195W)4
SEC311 |
Component of the Sec13p-Sec31p complex of the COPII more4
Sec31p1 |
43.13(n)1
28.47(a)1 |
|
4(107208-111029)4
8513321, 4 NP_010086.21 NP_010086.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G634606AT1G188306 |
transducin/WD-40 repeat-containing protein |
28(a)28(a) |
many ↔ manymany ↔ many |
3(23430642-23437374) 1(6489309-6494218) |
rice
(Oryza sativa) |
Liliopsida |
---- |
WD domain, G-beta repeat domain containing protein...WD domain, G-beta repeat domain containing protein... |
25(a)21(a) |
1 ↔ manypossible ortholog |
7(27654963-27664885) 2(1723476-1727642) |
ENSEMBL Gene Tree for SEC31A (if available)
TreeFam Gene Tree for SEC31A (if available) |
Paralogs
for SEC31A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEC31A gene
- SEC31B2
1 SIMAP similar gene for SEC31A using alignment to 19 protein entries: SC31A_HUMAN (see all proteins):SEC31B
SEC31A for paralogs About GeneDecksing
|
Genomic Variants
for SEC31A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEC31A (83739814 - 83822319 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEC31A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC31A |
|
Disorders
/ Diseases
for SEC31A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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|
SEC31A for disorders About GeneDecksing
OMIM gene information: 610257
OMIM disorders: --
UniProtKB/Swiss-Prot: SC31A_HUMAN, O94979
Note=A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs).Translocation t(2;4)(p23;q21) with ALK
6  diseases for SEC31A: About MalaCardsinflammatory myofibroblastic tumor b-cell lymphomas hodgkin's lymphoma stomatitis
choroiditis malaria
1 disease from the University of Copenhagen DISEASES database for SEC31A:Stomatitis Human Genome Epidemiology (HuGE) Navigator: SEC31A (1 document)
Export disorders for SEC31A gene to outside databases
|
Publications
for SEC31A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for SEC31A gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with SEC31A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport. (PubMed id 10788476)1, 2, 3 Tang B.L....Hong W. (2000)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner. (PubMed id 17196169)1, 2 Shibata H.... Maki M. (2007)
- Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor. (PubMed id 16161041)1, 2 Panagopoulos I.... Mandahl N. (2006)
- The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A. (PubMed id 16957052)1, 2 Yamasaki A.... Komada M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Ubiquitin-dependent regulation of COPII coat size and function. (PubMed id 22358839)2 Jin L.... Rape M. (2012)
- Epithelial organization and cyst lumen expansion requi re efficient Sec13-Sec31-driven secretion. (PubMed id 22331354)1 Townley A.K....Stephens D.J. (2012)
- Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
|
External Searches for SEC31A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing SEC31A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing SEC31A gene
(According to HUGE)
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| |
Specialized Databases showing SEC31A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for SEC31A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SEC31A gene:
Search GeneIP for patents involving SEC31A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SEC31A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SEC31A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC31A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC31A | | | OriGene Protein Over-expression Lysate for SEC31A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SEC31A | | OriGene 3'-UTR Clone for SEC31A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC31A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC31A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SEC31A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC31A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC31A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC31A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC31A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC31A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC31A |
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| | Antibodies & Assays for SEC31A (SEC31L1) |
| | | | Search Tocris compounds for SEC31A |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC31A |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC31A |
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