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Aliases for SEC31A Gene

Aliases for SEC31A Gene

  • SEC31 Homolog A, COPII Coat Complex Component 2 3 5
  • SEC31-Related Protein A 3 4
  • SEC31-Like Protein 1 3 4
  • Web1-Like Protein 3 4
  • SEC31L1 3 4
  • ABP125 3 4
  • ABP130 3 4
  • SEC31 Homolog A, COPII Coating Complex Component 3
  • Sec31 Homolog A (S. Cerevisiae) 2
  • SEC31-Like 1 (S. Cerevisiae) 2
  • Yeast Sec31p Homolog 3
  • KIAA0905 4
  • HSPC275 3
  • HSPC334 3

External Ids for SEC31A Gene

Previous HGNC Symbols for SEC31A Gene

  • SEC31L1

Previous GeneCards Identifiers for SEC31A Gene

  • GC04M083958
  • GC04M083739
  • GC04M079479

Summaries for SEC31A Gene

Entrez Gene Summary for SEC31A Gene

  • The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for SEC31A Gene

SEC31A (SEC31 Homolog A, COPII Coat Complex Component) is a Protein Coding gene. Diseases associated with SEC31A include inflammatory myofibroblastic tumor. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is SEC31B.

UniProtKB/Swiss-Prot for SEC31A Gene

  • Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).

Gene Wiki entry for SEC31A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC31A Gene

Genomics for SEC31A Gene

Regulatory Elements for SEC31A Gene

Promoters for SEC31A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC31A on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC31A Gene

Chromosome:
4
Start:
82,818,661 bp from pter
End:
82,901,166 bp from pter
Size:
82,506 bases
Orientation:
Minus strand

Genomic View for SEC31A Gene

Genes around SEC31A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC31A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC31A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC31A Gene

Proteins for SEC31A Gene

  • Protein details for SEC31A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94979-SC31A_HUMAN
    Recommended name:
    Protein transport protein Sec31A
    Protein Accession:
    O94979
    Secondary Accessions:
    • B4DIW6
    • B7ZKZ7
    • B7ZL00
    • H7C2W3
    • Q17RR5
    • Q5H9P6
    • Q5XG74
    • Q659G7
    • Q6ZU90
    • Q7LCX9
    • Q86TJ0
    • Q8IZH4
    • Q9P048
    • Q9P0A6
    • Q9UM05
    • Q9UM06

    Protein attributes for SEC31A Gene

    Size:
    1220 amino acids
    Molecular mass:
    133015 Da
    Quaternary structure:
    • COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12.
    SequenceCaution:
    • Sequence=AAF28953.1; Type=Frameshift; Positions=857, 1079; Evidence={ECO:0000305}; Sequence=AAF29012.1; Type=Frameshift; Positions=922, 946, 1029, 1080; Evidence={ECO:0000305}; Sequence=CAI45995.1; Type=Erroneous termination; Positions=221; Note=Translated as Trp.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC31A Gene

    Alternative splice isoforms for SEC31A Gene

neXtProt entry for SEC31A Gene

Proteomics data for SEC31A Gene at MOPED

Post-translational modifications for SEC31A Gene

  • Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.
  • Ubiquitination at Lys 111, Lys 488, Lys 647, Lys 729, and Lys 1217
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SEC31A (SEC31A)

No data available for DME Specific Peptides for SEC31A Gene

Domains & Families for SEC31A Gene

Gene Families for SEC31A Gene

Protein Domains for SEC31A Gene

Suggested Antigen Peptide Sequences for SEC31A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94979

UniProtKB/Swiss-Prot:

SC31A_HUMAN :
  • Belongs to the WD repeat SEC31 family.
  • Contains 8 WD repeats.
Family:
  • Belongs to the WD repeat SEC31 family.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with SEC31A: view

Function for SEC31A Gene

Molecular function for SEC31A Gene

UniProtKB/Swiss-Prot Function:
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).

Phenotypes for SEC31A Gene

GenomeRNAi human phenotypes for SEC31A:
genes like me logo Genes that share phenotypes with SEC31A: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC31A Gene

Localization for SEC31A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC31A Gene

Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Associates with membranes in a GTP-dependent manner. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC31A Gene COMPARTMENTS Subcellular localization image for SEC31A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 3

Gene Ontology (GO) - Cellular Components for SEC31A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0030134 ER to Golgi transport vesicle IDA 22358839
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0048471 perinuclear region of cytoplasm IDA 17196169
genes like me logo Genes that share ontologies with SEC31A: view

Pathways & Interactions for SEC31A Gene

genes like me logo Genes that share pathways with SEC31A: view

Gene Ontology (GO) - Biological Process for SEC31A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0015031 protein transport IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SEC31A: view

No data available for SIGNOR curated interactions for SEC31A Gene

Drugs & Compounds for SEC31A Gene

(2) Drugs for SEC31A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0
genes like me logo Genes that share compounds with SEC31A: view

Transcripts for SEC31A Gene

Unigene Clusters for SEC31A Gene

SEC31 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC31A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d · 7e ^
SP1: - - - - - - - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - - -
SP15: - - - - - -
SP16:
SP17:
SP18:
SP19:
SP20: - - - - - - -
SP21: - - - - - - - - - - - - - - - - - -
SP22: - - - - - - -
SP23: - - - - - - - - - - - - - - - - - - -
SP24:
SP25:
SP26: - - - - -
SP27: - - - -
SP28: - - - - - - - -
SP29: - -
SP30: - - - - - - - - -
SP31:
SP32: -
SP33: - - - - - - - -
SP34:

ExUns: 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - - - - - - - - - - - - - -
SP8:
SP9: - - - - - -
SP10:
SP11: - - - - -
SP12: - - - - -
SP13: - - - -
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21: - - - -
SP22:
SP23: - - - -
SP24:
SP25: -
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36a · 36b ^ 37a · 37b ^ 38 ^ 39a · 39b
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - -
SP7:
SP8: -
SP9:
SP10: - - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - -
SP17: - -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34: - -

Relevant External Links for SEC31A Gene

GeneLoc Exon Structure for
SEC31A
ECgene alternative splicing isoforms for
SEC31A

Expression for SEC31A Gene

mRNA expression in normal human tissues for SEC31A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC31A Gene

This gene is overexpressed in Bone marrow stromal cell (13.8) and Salivary gland (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC31A Gene



SOURCE GeneReport for Unigene cluster for SEC31A Gene Hs.370024

mRNA Expression by UniProt/SwissProt for SEC31A Gene

O94979-SC31A_HUMAN
Tissue specificity: Abundantly and ubiquitously expressed.
genes like me logo Genes that share expression patterns with SEC31A: view

Protein tissue co-expression partners for SEC31A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SEC31A Gene

Orthologs for SEC31A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC31A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC31A 35
  • 91.01 (n)
  • 93.36 (a)
SEC31A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC31A 35
  • 93.17 (n)
  • 94.27 (a)
SEC31A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec31a 35
  • 87.16 (n)
  • 91.93 (a)
Sec31a 16
Sec31a 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC31A 35
  • 99.83 (n)
  • 99.83 (a)
SEC31A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec31a 35
  • 85.72 (n)
  • 89.27 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC31A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC31A 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC31A 35
  • 73.99 (n)
  • 78.71 (a)
SEC31A 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC31A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec31a 35
  • 70.38 (n)
  • 72.88 (a)
Str.16319 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34077 35
zebrafish
(Danio rerio)
Actinopterygii sec31a 35
  • 63.99 (n)
  • 65.76 (a)
sec31p 35
sec31a 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2762 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011551 35
  • 48.39 (n)
  • 42.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec31 35
  • 47.98 (n)
  • 39.04 (a)
sec31 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-31 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC31 36
  • 22 (a)
OneToMany
SEC31 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5079 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8708 36
  • 42 (a)
OneToMany
Species with no ortholog for SEC31A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC31A Gene

ENSEMBL:
Gene Tree for SEC31A (if available)
TreeFam:
Gene Tree for SEC31A (if available)

Paralogs for SEC31A Gene

Paralogs for SEC31A Gene

genes like me logo Genes that share paralogs with SEC31A: view

Variants for SEC31A Gene

Sequence variations from dbSNP and Humsavar for SEC31A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs34554214 - 82,870,420(+) CAAAA(C/T)CCCCC reference, missense
rs35579207 - 82,844,490(+) AACCC(A/G)GAGGT reference, missense
rs35739017 - 82,827,497(+) ATGTG(G/T)CTGTG reference, missense
rs3797036 - 82,864,428(+) CAATA(A/C)TTGAT reference, missense
rs9690 -- 82,843,897(+) GATGT(A/C)AATAG intron-variant

Variation tolerance for SEC31A Gene

Residual Variation Intolerance Score: 9.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC31A Gene

HapMap Linkage Disequilibrium report
SEC31A
Human Gene Mutation Database (HGMD)
SEC31A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SEC31A Gene

Disorders for SEC31A Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEC31A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inflammatory myofibroblastic tumor
  • inflammatory fibrosarcoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SC31A_HUMAN
  • Note=A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.

Relevant External Links for SEC31A

Genetic Association Database (GAD)
SEC31A
Human Genome Epidemiology (HuGE) Navigator
SEC31A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC31A
genes like me logo Genes that share disorders with SEC31A: view

No data available for Genatlas for SEC31A Gene

Publications for SEC31A Gene

  1. Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport. (PMID: 10788476) Tang B.L. … Hong W. (J. Biol. Chem. 2000) 2 3 4 67
  2. Structural basis for cargo regulation of COPII coat assembly. (PMID: 18692470) Stagg S.M. … Balch W.E. (Cell 2008) 2 3
  3. A new role for annexin A11 in the early secretory pathway via stabilizing Sec31A protein at the endoplasmic reticulum exit sites (ERES). (PMID: 25540196) Shibata H. … Maki M. (J. Biol. Chem. 2015) 3
  4. Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2. (PMID: 25667979) Takahashi T. … Maki M. (Int J Mol Sci 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for SEC31A Gene

Sources for SEC31A Gene

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