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Aliases for SEC31A Gene

Aliases for SEC31A Gene

  • SEC31 Homolog A (S. Cerevisiae) 2 3
  • SEC31L1 3 4 6
  • SEC31-Related Protein A 3 4
  • SEC31-Like Protein 1 3 4
  • Web1-Like Protein 3 4
  • KIAA0905 4 6
  • ABP125 3 4
  • ABP130 3 4
  • Protein Transport Protein Sec31A 3
  • SEC31-Like 1 (S. Cerevisiae) 2
  • Yeast Sec31p Homolog 3
  • HSPC275 3
  • HSPC334 3

External Ids for SEC31A Gene

Previous HGNC Symbols for SEC31A Gene

  • SEC31L1

Previous GeneCards Identifiers for SEC31A Gene

  • GC04M083958
  • GC04M083739
  • GC04M079479

Summaries for SEC31A Gene

Entrez Gene Summary for SEC31A Gene

  • The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC31A Gene

SEC31A (SEC31 Homolog A (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with SEC31A include alk-positive large b-cell lymphoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). GO annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is SEC31B.

UniProtKB/Swiss-Prot for SEC31A Gene

  • Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).

Gene Wiki entry for SEC31A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC31A Gene

Genomics for SEC31A Gene

Regulatory Elements for SEC31A Gene

Genomic Location for SEC31A Gene

Start:
82,818,661 bp from pter
End:
82,901,166 bp from pter
Size:
82,506 bases
Orientation:
Minus strand

Genomic View for SEC31A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC31A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC31A Gene

Proteins for SEC31A Gene

  • Protein details for SEC31A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94979-SC31A_HUMAN
    Recommended name:
    Protein transport protein Sec31A
    Protein Accession:
    O94979
    Secondary Accessions:
    • B4DIW6
    • B7ZKZ7
    • B7ZL00
    • H7C2W3
    • Q17RR5
    • Q5H9P6
    • Q5XG74
    • Q659G7
    • Q6ZU90
    • Q7LCX9
    • Q86TJ0
    • Q8IZH4
    • Q9P048
    • Q9P0A6
    • Q9UM05
    • Q9UM06

    Protein attributes for SEC31A Gene

    Size:
    1220 amino acids
    Molecular mass:
    133015 Da
    Quaternary structure:
    • COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12.
    SequenceCaution:
    • Sequence=AAF28953.1; Type=Frameshift; Positions=857, 1079; Evidence={ECO:0000305}; Sequence=AAF29012.1; Type=Frameshift; Positions=922, 946, 1029, 1080; Evidence={ECO:0000305}; Sequence=CAI45995.1; Type=Erroneous termination; Positions=221; Note=Translated as Trp.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC31A Gene

    Alternative splice isoforms for SEC31A Gene

neXtProt entry for SEC31A Gene

Proteomics data for SEC31A Gene at MOPED

Post-translational modifications for SEC31A Gene

  • Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.
  • Ubiquitination at Lys111, Lys488, Lys647, Lys729, and Lys1217
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC31A Gene

Domains for SEC31A Gene

Gene Families for SEC31A Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for SEC31A Gene

Suggested Antigen Peptide Sequences for SEC31A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94979

UniProtKB/Swiss-Prot:

SC31A_HUMAN :
  • O94979
Family:
  • Belongs to the WD repeat SEC31 family.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with SEC31A: view

Function for SEC31A Gene

Molecular function for SEC31A Gene

UniProtKB/Swiss-Prot Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).

Gene Ontology (GO) - Molecular Function for SEC31A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16957052
GO:0048306 calcium-dependent protein binding IPI 16957052
genes like me logo Genes that share ontologies with SEC31A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC31A Gene

Localization for SEC31A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC31A Gene

Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Associates with membranes in a GTP-dependent manner. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC31A Gene COMPARTMENTS Subcellular localization image for SEC31A gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC31A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IDA 17196169
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SEC31A: view

Pathways for SEC31A Gene

genes like me logo Genes that share pathways with SEC31A: view

Gene Ontology (GO) - Biological Process for SEC31A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0015031 protein transport IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with SEC31A: view

Compounds for SEC31A Gene

(2) HMDB Compounds for SEC31A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with SEC31A: view

Transcripts for SEC31A Gene

Unigene Clusters for SEC31A Gene

SEC31 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC31A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d · 7e ^
SP1: - - - - - - - - - - - - - - - - - -
SP2:
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SP14: - - - - -
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SP20: - - - - - - -
SP21: - - - - - - - - - - - - - - - - - -
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SP23: - - - - - - - - - - - - - - - - - - -
SP24:
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SP26: - - - - -
SP27: - - - -
SP28: - - - - - - - -
SP29: - -
SP30: - - - - - - - - -
SP31:
SP32: -
SP33: - - - - - - - -
SP34:

ExUns: 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - - - - - - - - - - - - - -
SP8:
SP9: - - - - - -
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SP12: - - - - -
SP13: - - - -
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SP18: - -
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SP21: - - - -
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SP23: - - - -
SP24:
SP25: -
SP26:
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SP28:
SP29:
SP30:
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SP32:
SP33:
SP34:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36a · 36b ^ 37a · 37b ^ 38 ^ 39a · 39b
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - -
SP7:
SP8: -
SP9:
SP10: - - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - -
SP17: - -
SP18:
SP19:
SP20:
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SP23:
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SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34: - -

Relevant External Links for SEC31A Gene

GeneLoc Exon Structure for
SEC31A
ECgene alternative splicing isoforms for
SEC31A

Expression for SEC31A Gene

mRNA expression in normal human tissues for SEC31A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC31A Gene

SOURCE GeneReport for Unigene cluster for SEC31A Gene Hs.370024

mRNA Expression by UniProt/SwissProt for SEC31A Gene

O94979-SC31A_HUMAN
Tissue specificity: Abundantly and ubiquitously expressed.
genes like me logo Genes that share expressions with SEC31A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SEC31A Gene

Orthologs for SEC31A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC31A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC31A 35
  • 99.83 (n)
  • 99.83 (a)
SEC31A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC31A 35
  • 91.01 (n)
  • 93.36 (a)
SEC31A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC31A 35
  • 93.17 (n)
  • 94.27 (a)
SEC31A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec31a 35
  • 87.16 (n)
  • 91.93 (a)
Sec31a 16
Sec31a 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC31A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC31A 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec31a 35
  • 85.72 (n)
  • 89.27 (a)
chicken
(Gallus gallus)
Aves SEC31A 35
  • 73.99 (n)
  • 78.71 (a)
SEC31A 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC31A 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34077 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sec31a 35
  • 70.38 (n)
  • 72.88 (a)
Str.16319 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2762 35
zebrafish
(Danio rerio)
Actinopterygii sec31a 35
  • 63.99 (n)
  • 65.76 (a)
sec31a 36
  • 60 (a)
OneToOne
sec31p 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011551 35
  • 48.39 (n)
  • 42.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec31 35
  • 47.98 (n)
  • 39.04 (a)
sec31 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-31 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC31 36
  • 22 (a)
OneToMany
SEC31 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5079 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8708 36
  • 42 (a)
OneToMany
Species with no ortholog for SEC31A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC31A Gene

ENSEMBL:
Gene Tree for SEC31A (if available)
TreeFam:
Gene Tree for SEC31A (if available)

Paralogs for SEC31A Gene

Paralogs for SEC31A Gene

genes like me logo Genes that share paralogs with SEC31A: view

Variants for SEC31A Gene

Sequence variations from dbSNP and Humsavar for SEC31A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs9690 -- 82,843,897(+) GATGT(A/C)AATAG intron-variant
rs12490 -- 82,844,116(+) AATCA(C/T)GGGAC intron-variant
rs1020748 -- 82,892,865(+) cactg(A/G)tattt upstream-variant-2KB
rs1136882 -- 82,837,674(-) GTGAC(A/G)TGCTA intron-variant
rs1136884 -- 82,837,524(-) TGCCT(A/G)TATTC intron-variant

Relevant External Links for SEC31A Gene

HapMap Linkage Disequilibrium report
SEC31A
Human Gene Mutation Database (HGMD)
SEC31A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SEC31A Gene

Disorders for SEC31A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SEC31A Gene including...

Search for SEC31A Gene in MalaCards »

UniProtKB/Swiss-Prot

SC31A_HUMAN
  • Note=A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.

(1) University of Copenhagen DISEASES for SEC31A Gene

Relevant External Links for SEC31A

Genetic Association Database (GAD)
SEC31A
Human Genome Epidemiology (HuGE) Navigator
SEC31A
genes like me logo Genes that share disorders with SEC31A: view

Publications for SEC31A Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport. (PMID: 10788476) Tang B.L. … Hong W. (J. Biol. Chem. 2000) 2 3 4
  3. The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A. (PMID: 16957052) Yamasaki A. … Komada M. (Mol. Biol. Cell 2006) 3 4
  4. ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner. (PMID: 17196169) Shibata H. … Maki M. (Biochem. Biophys. Res. Commun. 2007) 3 4
  5. Ubiquitin-dependent regulation of COPII coat size and function. (PMID: 22358839) Jin L. … Rape M. (Nature 2012) 3 4

Products for SEC31A Gene

Sources for SEC31A Gene

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