Aliases for SEC31A Gene
External Ids for SEC31A Gene
Previous HGNC Symbols for SEC31A Gene
Previous GeneCards Identifiers for SEC31A Gene
The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEC31A Gene
SEC31A (SEC31 Homolog A (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with SEC31A include alk-positive large b-cell lymphoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). GO annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is SEC31B.
UniProtKB/Swiss-Prot for SEC31A Gene
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).