Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC24D Gene

protein-coding   GIFtS: 68
GCID: GC04M119643

SEC24 Family, Member D (S. Cerevisiae)

(Previous names: SEC24 (S. cerevisiae) related gene family, member D)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SEC24 Family, Member D (S. Cerevisiae)1 2
SEC24-Related Protein D2 3
SEC24 (S. Cerevisiae) Related Gene Family, Member D1
Protein Transport Protein Sec24D2
SEC24 Related Gene Family, Member D2
KIAA07553

External Ids:    HGNC: 107061   Entrez Gene: 98712   Ensembl: ENSG000001509617   OMIM: 6071865   UniProtKB: O948553   

Export aliases for SEC24D gene to outside databases

Previous GC identifers: GC04M120402 GC04M119924 GC04M120037 GC04M120102 GC04M120001 GC04M115365


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC24D Gene:
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved
in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat
protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of
the vesicle, and also in cargo selection and concentration. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEC24D Gene: 
SEC24D (SEC24 family, member D (S. cerevisiae)) is a protein-coding gene. Diseases associated with SEC24D include liddle syndrome, and alcohol dependence, and among its related super-pathways are COPII (Coat Protein 2) Mediated Vesicle Transport and Clathrin-dependent protein traffic. GO annotations related to this gene include molecular_function and zinc ion binding. An important paralog of this gene is SEC24A.

UniProtKB/Swiss-Prot: SC24D_HUMAN, O94855
Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma
membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for SEC24D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC24D gene promoter:
         AREB6   c-Rel   PPAR-gamma1   RFX1   Pax-3   AP-1   Bach2   PPAR-gamma2   Nkx5-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC24D promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC24D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC24D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

SEC24D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC24D gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M119643:  view genomic region     (about GC identifiers)

Start:
119,643,978 bp from pter      End:
119,759,838 bp from pter
Size:
115,861 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SC24D_HUMAN, O94855 (See protein sequence)
Recommended Name: Protein transport protein Sec24D  
Size: 1032 amino acids; 113010 Da
Subunit: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1.
Interacts with TMED2 and TMED10
Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Endoplasmic
reticulum membrane (By similarity). Golgi apparatus membrane (By similarity)
Sequence caution: Sequence=BAA34475.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for SEC24D:
3EFO (3D)        3EG9 (3D)    
Secondary accessions: Q8IYI7
Alternative splicing: 2 isoforms:  O94855-1   O94855-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC24D: NX_O94855

Explore proteomics data for SEC24D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94855

  • SEC24D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEC24D Protein Expression
    REFSEQ proteins: NP_055637.2  
    ENSEMBL proteins: 
     ENSP00000280551   ENSP00000425491   ENSP00000422717   ENSP00000424085   ENSP00000427249  
     ENSP00000426309   ENSP00000369059   ENSP00000409775   ENSP00000388324  
    Reactome Protein details: O94855
    Human Recombinant Protein Products for SEC24D: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SEC24D
    OriGene Protein Over-expression Lysate for SEC24D
    OriGene MassSpec for SEC24D 
    OriGene Custom Protein Services for SEC24D
    GenScript Custom Purified and Recombinant Proteins Services for SEC24D
    Novus Biologicals SEC24D Protein
    Novus Biologicals SEC24D Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC24D 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005829cytosol TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0030127COPII vesicle coat NAS10329445

    SEC24D for ontologies           About GeneDecksing



    SEC24D Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SEC24D 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEC24D
    GenScript Custom Superior Antibodies Services for SEC24D
    Novus Biologicals SEC24D Antibodies
    Abcam antibodies for SEC24D
    Cloud-Clone Corp. Antibodies for SEC24D 
    ThermoFisher Antibodies for SEC24D
    LSBio Antibodies in human, mouse, rat for SEC24D 

    Assay Products for SEC24D: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEC24D
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEC24D
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEC24D 
    Cloud-Clone Corp. CLIAs for SEC24D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR006900 Sec23/24_helical_dom
     IPR012990 Sec23_24_beta_S
     IPR006896 Sec23/24_trunk_dom
     IPR006895 Znf_Sec23_Sec24
     IPR007123 Gelsolin_dom

    Graphical View of Domain Structure for InterPro Entry O94855

    ProtoNet protein and cluster: O94855

    3 Blocks protein domains:
    IPB006895 Sec23/Sec24 zinc finger
    IPB006896 Sec23/Sec24 trunk domain
    IPB006900 Sec23/Sec24 helical domain


    UniProtKB/Swiss-Prot: SC24D_HUMAN, O94855
    Similarity: Belongs to the SEC23/SEC24 family. SEC24 subfamily


    SEC24D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC24D_HUMAN, O94855
    Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
    reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma
    membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

         Genatlas biochemistry entry for SEC24D:
    SEC24 (S. cerevisiae) related gene family, member D

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008270zinc ion binding IEA--
         
    SEC24D for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SEC24D:
     Increased G1 DNA content  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEC24D 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEC24D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC24D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC24D 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC24D:
    hsa-mir-605 (MIRT001230)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC24D
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24D:
    hsa-miR-3607-3p hsa-miR-204 hsa-miR-1284 hsa-miR-211 hsa-miR-3144-3p
    SwitchGear 3'UTR luciferase reporter plasmidSEC24D 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEC24D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC24D

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC24D
    Sirion Biotech Customized adenovirus for overexpression of SEC24D

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SEC24D (see all 9)
    OriGene ORF clones in mouse, rat for SEC24D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC24D (NM_014822)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC24D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24D
    Sirion Biotech Customized lentivirus for stable overexpression of SEC24D 
                         Customized lentivirus expression plasmids for stable overexpression of SEC24D 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEC24D
    Search LifeMap BioReagents cell lines for SEC24D
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEC24D About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1COPII (Coat Protein 2) Mediated Vesicle Transport
    COPII (Coat Protein 2) Mediated Vesicle Transport0.36
    ER to Golgi Transport0.36
    Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC0.31
    Normal wtCFTR traffic / ER-to-Golgi 0.36
    2Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.67
    SREBP signalling0.37
    4Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SEC24D
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC24D
        SREBP Proteolysis

    1 Cell Signaling Technology (CST) Pathway for SEC24D
        Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for SEC24D
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SEC24D
        SREBP signalling

    5/18        Reactome Pathways for SEC24D (see all 18)
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Membrane Trafficking
    Metabolism
    COPII (Coat Protein 2) Mediated Vesicle Transport
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)


    1         Kegg Pathway  (Kegg details for SEC24D):
        Protein processing in endoplasmic reticulum


    SEC24D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEC24D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for SEC24D (O948552, 3 ENSP000002805514) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO4P619682, 3MINT-60898 I2D: score=3 
    SEC23AQ154362, 3, ENSP000003068814MINT-7299563 I2D: score=1 STRING: ENSP00000306881
    SEC23BQ154373, ENSP000002625444I2D: score=5 STRING: ENSP00000262544
    CDK16Q005363, ENSP000004057984I2D: score=1 STRING: ENSP00000405798
    DCTN1Q142033, ENSP000003547914I2D: score=1 STRING: ENSP00000354791
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    SEC24D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC24D (SC24D)

    Search CenterWatch for drugs/clinical trials and news about SEC24D / SC24D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC24D gene: 
    NM_014822.2  

    Unigene Cluster for SEC24D:

    SEC24 family, member D (S. cerevisiae)
    Hs.189641  [show with all ESTs]
    Unigene Representative Sequence: NM_014822
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280551 ENST00000505134(uc003ich.4) ENST00000511481 ENST00000502830
    ENST00000511715(uc003ick.2) ENST00000514561(uc003icl.2) ENST00000502526
    ENST00000511033 ENST00000509818(uc010imz.1) ENST00000514418 ENST00000506622(uc011cgg.1)
    ENST00000503683 ENST00000505280 ENST00000379735(uc003ici.4 uc003icj.4)
    ENST00000429811 ENST00000419654
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC24D
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24D:
    hsa-miR-3607-3p hsa-miR-204 hsa-miR-1284 hsa-miR-211 hsa-miR-3144-3p
    SwitchGear 3'UTR luciferase reporter plasmidSEC24D 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEC24D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC24D
    Clone
    Products:
         
    OriGene clones in human, mouse for SEC24D (see all 9)
    OriGene ORF clones in mouse, rat for SEC24D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC24D (NM_014822)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC24D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24D
    Sirion Biotech Customized lentivirus for stable overexpression of SEC24D 
                         Customized lentivirus expression plasmids for stable overexpression of SEC24D 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC24D
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC24D
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC24D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC24D

    Additional mRNA sequence: 

    AB018298.1 AF130464.2 AK000883.1 AK001390.1 AK125962.1 AK291765.1 AK302479.1 AK309960.1 
    AK310259.1 BC035761.1 BC037736.1 

    19 DOTS entries:

    DT.417374  DT.75134464  DT.100662404  DT.91878300  DT.121234119  DT.91858537  DT.92440019  DT.121234093 
    DT.91716167  DT.92440021  DT.100788803  DT.121234057  DT.121234074  DT.121234092  DT.121234100  DT.75105122 
    DT.75131798  DT.95184497  DT.97821473 

    24/256 AceView cDNA sequences (see all 256):

    BM457291 AW954175 AA732906 BM710726 CB265904 AL599106 CB158675 AI087408 
    AK001390 BU736336 BM982217 BE673206 BC035761 BX486015 BI492231 BX088911 
    BX281586 AV716555 BG163382 AW473323 Z38445 BQ269854 BM979461 BX282071 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SEC24D    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                          -                                                           -     -     -                                                         
    SP2:                          -                                                           -     -     -                                                         
    SP3:        -     -                                                                       -                                                                     
    SP4:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:  -                           
    SP2:  -                           
    SP3:                              
    SP4:                              


    ECgene alternative splicing isoforms for SEC24D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC24D expression in normal human tissues (normalized intensities)      SEC24D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTCCATT
    SEC24D Expression
    About this image


    SEC24D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             optic nerve head astrocytes   
     
     Testis (Reproductive System)
             sperm   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   
     
     Eye (Sensory Organs)
             optic nerve head astrocytes   

    See SEC24D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC24D

    SOURCE GeneReport for Unigene cluster: Hs.189641

    UniProtKB/Swiss-Prot: SC24D_HUMAN, O94855
    Tissue specificity: Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver

        SABiosciences Custom PCR Arrays for SEC24D
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC24D
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC24D
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC24D
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC24D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC24D gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec24d1 , 5 Sec24 related gene family, member D (S. cerevisiae)1, 5 83.72(n)1
    88.35(a)1
      3 (53.82 cM)5
    696081  NM_027135.21  NP_081411.21 
     1232674965 
    chicken
    (Gallus gallus)
    Aves SEC24D1 SEC24 family, member D (S. cerevisiae) 73.97(n)
    76.61(a)
      422683  XM_420635.3  XP_420635.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEC24D6
    SEC24 family, member D (S. cerevisiae)
    73(a)
    1 ↔ 1
    5(140305566-140373809)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377097502   -- 77.11(n)    137709750 
    zebrafish
    (Danio rerio)
    Actinopterygii sec24d1 SEC24 family, member D (S. cerevisiae) 67.07(n)
    67.77(a)
      553407  NM_001177932.1  NP_001171403.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108823 serine-type endopeptidase 48(a)   22D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea sec-24.13 Yeast hypothetical YIK9 protein like 40(a)   IV(11562517-11563694)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SFB26
    SEC246
    Component of the Sec23p-Sfb2p heterodimer of the C...
    Component of the Sec23p-Sec24p heterodimer of the ...
    23(a)
    23(a)
    many ↔ many
    many ↔ many
    XIV(535281-537911)
    IX(157385-160165)


    ENSEMBL Gene Tree for SEC24D (if available)
    TreeFam Gene Tree for SEC24D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC24D gene
    SEC24A2  SEC24C2  SEC24B2  
    3 SIMAP similar genes for SEC24D using alignment to 9 protein entries:     SC24D_HUMAN (see all proteins):
    SEC24C    SEC24A    SEC24B

    SEC24D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2283 SNPs in SEC24D are shown (see all 2283)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423729781,2
    --119643582(+) GACACA/GATATG 1 -- ds50010--------
    rs1509830801,2
    --119643672(+) TGACAG/TCACTC 1 -- ds50010--------
    rs1497798311,2
    C--119643739(+) TCTAT-/TTATTATT 1 -- cds10--------
    rs1829382941,2
    --119643807(+) GTTTCC/TTAGAT 1 -- ds50010--------
    rs764968241,2
    C,F--119643863(+) TGTTTT/CCCTGA 1 -- ds50011Minor allele frequency- C:0.11WA 118
    rs1395453171,2
    --119643968(+) AATAAA/GTCTAC 1 -- ds50010--------
    rs1497224071,2
    C--119643989(+) TATACA/GAAGTG 1 -- ut310--------
    rs1869285961,2
    --119644000(+) ATTTAC/TTGATA 1 -- ut310--------
    rs1467464491,2
    --119644046(+) CAAAAC/TTGTAC 1 -- ut310--------
    rs1918319891,2
    --119644055(+) ACAAAC/GAACCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SEC24D (119643978 - 119759838 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEC24D:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519017CNV Loss19592680
    nsv516777CNV Gain19592680
    essv11621CNV CNV17122850
    dgv1668e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC24D
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC24D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607186    OMIM disorders: --

    3 diseases for SEC24D:    About MalaCards
    liddle syndrome    alcohol dependence    alcoholism

    1 disease from the University of Copenhagen DISEASES database for SEC24D:
    Liddle syndrome

    SEC24D for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEC24D
    Human Genome Epidemiology (HuGE) Navigator: SEC24D (2 documents)

    Export disorders for SEC24D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC24D gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SEC24D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A family of mammalian proteins homologous to yeast Sec24p. (PubMed id 10329445)1, 2 Tang B.L....Hong W. (1999)
    5. Sec24 proteins and sorting at the endoplasmic reticulum. (PubMed id 10075675)1, 3 Pagano A....Paccaud J.P. (1999)
    6. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. (PubMed id 20427317)2, 9 Bonnon C....Hauri H.P. (2010)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A triple arg motif mediates a(2B)-adrenergic receptor interaction with Sec24C/D and export. (PubMed id 22404651)1 Dong C....Wu G. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9871 HGNC: 10706 AceView: SEC24D Ensembl:ENSG00000150961 euGenes: HUgn9871
    ECgene: SEC24D Kegg: 9871 H-InvDB: SEC24D

    (According to HUGE)
    About This Section
    HUGE: KIAA0755

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC24D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC24D gene:
    Search GeneIP for patents involving SEC24D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEC24D  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SEC24D  
     OriGene MassSpec something-or-other for SEC24D   OriGene clones in human, mouse for SEC24D  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEC24D   OriGene Purified Protein for SEC24D  
     OriGene ORF clones in mouse, rat for SEC24D   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEC24D   OriGene Custom Protein Services for SEC24D  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC24D
     QIAGEN SeqTarget long-range PCR primers for resequencing SEC24D
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC24D
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC24D
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC24D
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC24D
     GenScript Custom Purified and Recombinant Proteins Services for SEC24D GenScript cDNA clones with any tag delivered in your preferred vector for SEC24D
     GenScript Custom Assay Services for SEC24D GenScript Custom Superior Antibodies Services for SEC24D
     GenScript Custom overexpressing Cell Line Services for SEC24D CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SEC24D 

     Regulatory tfbs in SEC24D promoter
     Search Chromatin IP Primers for SEC24D
     RT2 qPCR Primer Assay in human, mouse, rat SEC24D
     GNC Network for SEC24D
     SABiosciences PCR Arrays including human, mouse, rat SEC24D
     Search Tocris compounds for SEC24D (SC24D)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SEC24D antibodies
     SEC24D proteins
     SEC24D lysates
     Antibodies for SEC24D
     See all of Abcam's Antibodies, Kits and Proteins for SEC24D
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SEC24D
     Antibodies for SEC24D
     ELISAs for SEC24D
     CLIAs for SEC24D
     Search LifeMap BioReagents cell lines for SEC24D
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24D
     SwitchGear 3'UTR luciferase reporter plasmids for SEC24D
     SwitchGear Promoter luciferase reporter plasmids for SEC24D
     ThermoFisher Antibodies for SEC24D
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24D
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SEC24D
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEC24D
    Customized:
     lentivirus for stable overexpression of SEC24D
     lentivirus expression plasmids for stable overexpression of SEC24D
     adenovirus for overexpression of SEC24D
     LSBio Antibodies in human, mouse, rat for SEC24D
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEC24D gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4