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Aliases for SEC24D Gene

Aliases for SEC24D Gene

  • SEC24 Family Member D 2 3
  • SEC24-Related Protein D 3 4
  • SEC24 (S. Cerevisiae) Related Gene Family, Member D 2
  • SEC24 Family, Member D (S. Cerevisiae) 2
  • SEC24 Related Gene Family, Member D 3
  • Protein Transport Protein Sec24D 3
  • KIAA0755 4
  • CLCRP2 3

External Ids for SEC24D Gene

Summaries for SEC24D Gene

Entrez Gene Summary for SEC24D Gene

  • The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC24D Gene

SEC24D (SEC24 Family Member D) is a Protein Coding gene. Diseases associated with SEC24D include liddle syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). An important paralog of this gene is SEC24B.

UniProtKB/Swiss-Prot for SEC24D Gene

  • Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for SEC24D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC24D Gene

Genomics for SEC24D Gene

Genomic Location for SEC24D Gene

Start:
118,722,823 bp from pter
End:
118,838,683 bp from pter
Size:
115,861 bases
Orientation:
Minus strand

Genomic View for SEC24D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC24D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC24D Gene

Regulatory Elements for SEC24D Gene

Proteins for SEC24D Gene

  • Protein details for SEC24D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94855-SC24D_HUMAN
    Recommended name:
    Protein transport protein Sec24D
    Protein Accession:
    O94855
    Secondary Accessions:
    • Q8IYI7

    Protein attributes for SEC24D Gene

    Size:
    1032 amino acids
    Molecular mass:
    113010 Da
    Quaternary structure:
    • COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with TMED2 and TMED10. Interacts with CNIH4 (PubMed:24405750).
    SequenceCaution:
    • Sequence=BAA34475.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC24D Gene

    Alternative splice isoforms for SEC24D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC24D Gene

Proteomics data for SEC24D Gene at MOPED

Post-translational modifications for SEC24D Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys795

Other Protein References for SEC24D Gene

No data available for DME Specific Peptides for SEC24D Gene

Domains for SEC24D Gene

UniProtKB/Swiss-Prot:

SC24D_HUMAN
Family:
  • Belongs to the SEC23/SEC24 family. SEC24 subfamily.:
    • O94855
genes like me logo Genes that share domains with SEC24D: view

No data available for Gene Families for SEC24D Gene

Function for SEC24D Gene

Molecular function for SEC24D Gene

GENATLAS Biochemistry: SEC24 (S. cerevisiae) related gene family, member D
UniProtKB/Swiss-Prot Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Ontology (GO) - Molecular Function for SEC24D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SEC24D: view

Phenotypes for SEC24D Gene

genes like me logo Genes that share phenotypes with SEC24D: view

miRNA for SEC24D Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC24D Gene

Localization for SEC24D Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC24D Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane. Golgi apparatus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC24D Gene COMPARTMENTS Subcellular localization image for SEC24D gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
golgi apparatus 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEC24D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0030127 COPII vesicle coat NAS 10329445
genes like me logo Genes that share ontologies with SEC24D: view

Pathways for SEC24D Gene

genes like me logo Genes that share pathways with SEC24D: view

Pathways by source for SEC24D Gene

1 Qiagen pathway for SEC24D Gene
1 Cell Signaling Technology pathway for SEC24D Gene

Gene Ontology (GO) - Biological Process for SEC24D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with SEC24D: view

Transcripts for SEC24D Gene

Unigene Clusters for SEC24D Gene

SEC24 family, member D (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC24D Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for SEC24D Gene

GeneLoc Exon Structure for
SEC24D
ECgene alternative splicing isoforms for
SEC24D

Expression for SEC24D Gene

mRNA expression in normal human tissues for SEC24D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC24D Gene

SOURCE GeneReport for Unigene cluster for SEC24D Gene Hs.189641

mRNA Expression by UniProt/SwissProt for SEC24D Gene

O94855-SC24D_HUMAN
Tissue specificity: Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver
genes like me logo Genes that share expressions with SEC24D: view

Orthologs for SEC24D Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC24D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC24D 36
  • 97.47 (n)
  • 97.37 (a)
cow
(Bos Taurus)
Mammalia SEC24D 36
  • 87.14 (n)
  • 91.76 (a)
SEC24D 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC24D 36
  • 90.36 (n)
  • 92.5 (a)
SEC24D 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec24d 36
  • 83.72 (n)
  • 88.35 (a)
Sec24d 16
Sec24d 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC24D 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC24D 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec24d 36
  • 83.56 (n)
  • 88.18 (a)
chicken
(Gallus gallus)
Aves SEC24D 36
  • 74.63 (n)
  • 78.1 (a)
SEC24D 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC24D 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec24d 36
  • 69.61 (n)
  • 69.74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10576 36
zebrafish
(Danio rerio)
Actinopterygii sec24d 36
  • 66.24 (n)
  • 66.73 (a)
sec24d 37
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gho 37
  • 39 (a)
OneToMany
CG10882 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea sec-24.1 37
  • 35 (a)
OneToMany
sec-24.1 38
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC24 37
  • 23 (a)
ManyToMany
SFB2 37
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9094 37
  • 52 (a)
OneToMany
Species with no ortholog for SEC24D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC24D Gene

ENSEMBL:
Gene Tree for SEC24D (if available)
TreeFam:
Gene Tree for SEC24D (if available)

Paralogs for SEC24D Gene

Paralogs for SEC24D Gene

Selected SIMAP similar genes for SEC24D Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SEC24D: view

Variants for SEC24D Gene

Sequence variations from dbSNP and Humsavar for SEC24D Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs15128 -- 118,722,972(-) TTATA(C/T)ATTGT utr-variant-3-prime
rs298987 -- 118,727,489(-) GCAGA(A/G)AAGAG intron-variant
rs298988 -- 118,727,244(-) TACTA(C/T)CTGCA intron-variant
rs298989 -- 118,725,718(-) CAAGG(C/G)TGACA intron-variant
rs298990 -- 118,725,518(-) TGGAA(C/T)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC24D Gene

Variant ID Type Subtype PubMed ID
dgv1668e1 CNV Complex 17122850
nsv519017 CNV Loss 19592680
essv11621 CNV CNV 17122850
nsv516777 CNV Gain 19592680

Relevant External Links for SEC24D Gene

HapMap Linkage Disequilibrium report
SEC24D
Human Gene Mutation Database (HGMD)
SEC24D

Disorders for SEC24D Gene

(1) MalaCards Diseases for SEC24D Gene

Search for SEC24D Gene in MalaCards »

(1) University of Copenhagen DISEASES for SEC24D Gene

Relevant External Links for SEC24D

Genetic Association Database (GAD)
SEC24D
Human Genome Epidemiology (HuGE) Navigator
SEC24D
genes like me logo Genes that share disorders with SEC24D: view

No data available for UniProtKB/Swiss-Prot for SEC24D Gene

Publications for SEC24D Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Sec24 proteins and sorting at the endoplasmic reticulum. (PMID: 10075675) Pagano A. … Paccaud J.-P. (J. Biol. Chem. 1999) 2 3
  3. A family of mammalian proteins homologous to yeast Sec24p. (PMID: 10329445) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1999) 3 4
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for SEC24D Gene

Sources for SEC24D Gene

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