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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEC24D Gene

protein-coding GIFtS: 65
GCID: GC04M119643

SEC24 family, member D (S. cerevisiae)

(Previous names: SEC24 (S. cerevisiae) related gene family, member D )

Explore 4 diseases affiliated with
SEC24D via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SEC24 Family, Member D (S. Cerevisiae)¹ ²
KIAA0755¹ ³
SEC24-Related Protein D² ³
SEC24 (S. Cerevisiae) Related Gene Family, Member D¹
Protein Transport Protein Sec24D²
SEC24 Related Gene Family, Member D²

External Ids:	HGNC: 10706¹	Entrez Gene: 9871²	Ensembl: ENSG00000150961⁷	OMIM: 607186⁵	UniProtKB: O94855³

Export aliases for SEC24D gene to outside databases

Previous GC identifers: GC04M120402 GC04M119924 GC04M120037 GC04M120102 GC04M120001 GC04M115365

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC24D:

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in

vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein

complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle,

and also in cargo selection and concentration. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SC24D_HUMAN, O94855

Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic

reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane,

and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for SEC24D

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEC24D gene promoter:
AREB6 c-Rel PPAR-gamma1 RFX1 Pax-3 AP-1 Bach2 PPAR-gamma2 Nkx5-1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEC24D promoter sequence

Search SABiosciences Chromatin IP Primers for SEC24D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC24D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26 Ensembl cytogenetic band: 4q26 HGNC cytogenetic band: 4q26

SEC24D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC24D gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M119643: view genomic region (about GC identifiers)

Start:	119,643,978 bp from pter	End:	119,759,838 bp from pter
Size:	115,861 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SC24D_HUMAN, O94855 (See protein sequence)

Recommended Name: Protein transport protein Sec24D

Size: 1032 amino acids; 113010 Da

Subunit: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts

with TMED2 and TMED10

Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Endoplasmic reticulum

membrane (By similarity). Golgi apparatus membrane (By similarity)

Sequence caution: Sequence=BAA34475.2; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for SEC24D:

3EFO (3D)

3EG9 (3D)

Secondary accessions: Q8IYI7

Alternative splicing: 2 isoforms: O94855-1 O94855-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC24D: NX_O94855

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94855

SEC24D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055637.2

ENSEMBL proteins:

ENSP00000280551 ENSP00000425491 ENSP00000422717 ENSP00000424085 ENSP00000427249

ENSP00000426309 ENSP00000369059 ENSP00000409775 ENSP00000388324

Reactome Protein details: O94855
Human Recombinant Protein Products for SEC24D:

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	Novus Biologicals SEC24D Protein Novus Biologicals SEC24D Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEC24D

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005829	cytosol	TAS	--
GO:0012507	ER to Golgi transport vesicle membrane	TAS	--
GO:0030127	COPII vesicle coat	NAS	10329445

SEC24D for ontologies About GeneDecksing

SEC24D Antibody Products:

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Assay Products for SEC24D:

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	Uscn ELISAs and CLIAs for SEC24D

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEC24D for domains About GeneDecksing

5 InterPro domains/families:

IPR006900 Sec23/24_helical_dom

IPR012990 Sec23_24_beta_S

IPR006896 Sec23/24_trunk_dom

IPR006895 Znf_Sec23_Sec24

IPR007123 Gelsolin_dom

Graphical View of Domain Structure for InterPro Entry O94855

ProtoNet protein and cluster: O94855

3 Blocks protein families:

IPB006895 Sec23/Sec24 zinc finger

IPB006896 Sec23/Sec24 trunk domain

IPB006900 Sec23/Sec24 helical domain

UniProtKB/Swiss-Prot: SC24D_HUMAN, O94855

Similarity: Belongs to the SEC23/SEC24 family. SEC24 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SC24D_HUMAN, O94855

Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic

reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane,

and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Genatlas biochemistry entry for SEC24D:

SEC24 (S. cerevisiae) related gene family, member D

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0008270	zinc ion binding	IEA	--

SEC24D for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SEC24D:

Increased G1 DNA content

Increased number of cells in m

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEC24D

miRNA Products:		miRTarBase miRNAs that target SEC24D: hsa-mir-605 (MIRT001230)

		OriGene 3'-UTR Clone: SEC24D Browse MicroRNA Expression Plasmids
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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24D:
		hsa-miR-3607-3p hsa-miR-204 hsa-miR-1284 hsa-miR-211 hsa-miR-3144-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SEC24D 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC24D (see all 7) OriGene shRNA RFP: SEC24D OriGene siRNA: SEC24D
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24D

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

COPII (Coat Protein 2) Mediated Vesicle Transport

COPII (Coat Protein 2) Mediated Vesicle Transport	1.00	SREBP1A/1C/2:SCAP Transits to the Golgi	0.50
ER to Golgi Transport	1.00	Delta508-CFTR traffic / ER-to-Golgi in CF	0.36
SREBP1A/1C/2:SCAP Binds CopII Coat Complex	0.50	Normal wtCFTR traffic / ER-to-Golgi	0.36

Clathrin-dependent protein traffic

	Clathrin-dependent protein traffic	1.00			wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)	0.37
	Transport_Clathrin-coated vesicle cycle	0.66

Asparagine N-linked glycosylation

	Asparagine N-linked glycosylation	1.00			Metabolism of proteins	0.15
	Post-translational protein modification	0.44

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

1.00

SREBP signalling

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SEC24D

Clathrin-dependent protein traffic

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC24D

SREBP Proteolysis

1 Cell Signaling Technology (CST) Pathway for SEC24D

Cytoskeletal Signaling

4 GeneGo (Thomson Reuters) Pathways for SEC24D

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Delta508-CFTR traffic / ER-to-Golgi in CF
	Normal wtCFTR traffic / ER-to-Golgi
	Transport Clathrin-coated vesicle cycle

1 BioSystems Pathway for SEC24D

SREBP signalling

5/17 Reactome Pathways for SEC24D (see all 17)

	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
	Membrane Trafficking
	Metabolism
	COPII (Coat Protein 2) Mediated Vesicle Transport
	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

1 Kegg Pathway (Kegg details for SEC24D):

Protein processing in endoplasmic reticulum

SEC24D for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SEC24D

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/73 Interacting proteins for SEC24D (O94855^{2, 3} ENSP00000280551⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 73)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LMO4	P61968²^,³	MINT-60898 I2D: score=3
SEC23A	Q15436²^,³, ENSP00000306881⁴	MINT-7299563 I2D: score=1 STRING: ENSP00000306881
SEC23B	Q15437³, ENSP00000262544⁴	I2D: score=5 STRING: ENSP00000262544
CDK16	Q00536³, ENSP00000405798⁴	I2D: score=1 STRING: ENSP00000405798
DCTN1	Q14203³, ENSP00000354791⁴	I2D: score=1 STRING: ENSP00000354791

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0006886	intracellular protein transport	IEA	--
GO:0006888	ER to Golgi vesicle-mediated transport	TAS	--
GO:0016044	cellular membrane organization	TAS	--
GO:0018279	protein N-linked glycosylation via asparagine	TAS	--

SEC24D for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEC24D
Search CenterWatch for drugs/clinical trials and news about SEC24D / SC24D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEC24D gene:

NM_014822.2

Unigene Cluster for SEC24D:

SEC24 family, member D (S. cerevisiae)

Hs.189641 [show with all ESTs]

Unigene Representative Sequence: NM_014822

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000280551 ENST00000505134(uc003ich.4) ENST00000511481 ENST00000502830

ENST00000511715(uc003ick.2) ENST00000514561(uc003icl.2) ENST00000502526

ENST00000511033 ENST00000509818(uc010imz.1) ENST00000514418 ENST00000506622(uc011cgg.1)

ENST00000503683 ENST00000505280 ENST00000379735(uc003ici.4 uc003icj.4)

ENST00000429811 ENST00000419654

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		hsa-miR-3607-3p hsa-miR-204 hsa-miR-1284 hsa-miR-211 hsa-miR-3144-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SEC24D 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB018298.1 AF130464.2 AK000883.1 AK001390.1 AK125962.1 AK291765.1 AK302479.1 AK309960.1

AK310259.1 BC035761.1 BC037736.1

19 DOTS entries:

DT.417374 DT.75134464 DT.100662404 DT.91878300 DT.121234119 DT.91858537 DT.92440019 DT.121234093

DT.91716167 DT.92440021 DT.100788803 DT.121234057 DT.121234074 DT.121234092 DT.121234100 DT.75105122

DT.75131798 DT.95184497 DT.97821473

24/256 AceView cDNA sequences (see all 256):

BU626249 AL599106 AK001390 CA446443 CK821540 AW954175 BG163382 BG679441

BE302288 BI492231 BX486015 BE673206 BM982217 BG527683 BU736336 CB158675

AV716555 BQ269854 BM661808 AU126034 CB265904 BM457291 AI952893 AA814666

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SEC24D About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:									-																				-		-		-
SP2:									-																				-		-		-
SP3:			-		-																								-
SP4:

ExUns:	24	^	25	^	26	^	27	^	28
SP1:	-
SP2:	-
SP3:
SP4:

ECgene alternative splicing isoforms for SEC24D

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEC24D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACTCCATT

About this image

SEC24D expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Cerebral Cortex

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEC24D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC24D

SOURCE GeneReport for Unigene cluster: Hs.189641

UniProtKB/Swiss-Prot: SC24D_HUMAN, O94855

Tissue specificity: Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver

SABiosciences Custom PCR Arrays for SEC24D

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24D

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC24D gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEC24D¹	SEC24 family, member D (S. cerevisiae)	73.97(n) 76.61(a)		422683 XM_420635.3 XP_420635.2
lizard (Anolis carolinensis)	Reptilia	SEC24D⁶	--	71(a)	1 ↔ 1	5(140317119-140373086)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137709750²	--	77.11(n)		137709750
zebrafish (Danio rerio)	Actinopterygii	sec24d¹	SEC24 family, member D (S. cerevisiae)	67.07(n) 67.77(a)		553407 NM_001177932.1 NP_001171403.1
fruit fly (Drosophila melanogaster)	Insecta	CG10882³	serine-type endopeptidase	48(a)		22D5 --
worm (Caenorhabditis elegans)	Secernentea	sec-24.1³	Yeast hypothetical YIK9 protein like	40(a)		IV(11562517-11563694) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G32640⁶ CEF⁶	transport protein sec24-like CEF	26(a) 26(a)	many ↔ many many ↔ many	4(15742001-15750862) 3(16011621-16020254)
rice (Oryza sativa)	Liliopsida	-- --	protein transport protein, putative, expressed retrotransposon protein, putative, unclassified, e...	33(a) 23(a)	many ↔ many many ↔ many	11(16460663-16472036) 12(13813000-13827130)

ENSEMBL Gene Tree for SEC24D (if available)
TreeFam Gene Tree for SEC24D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEC24D gene

SEC24A² SEC24C² SEC24B²

3 SIMAP similar genes for SEC24D using alignment to 9 protein entries: SC24D_HUMAN (see all proteins):

SEC24C SEC24A SEC24B

SEC24D for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142372978^1,2		--	119643582(+)	`GACACA/GATATG`	1	--	ds500¹		0	--	--	--	--
rs150983080^1,2		--	119643672(+)	`TGACAG/TCACTC`	1	--	ds500¹		0	--	--	--	--
rs149779831^1,2	C	--	119643739(+)	`TCTAT-/TTATTATT`	1	--	ds500¹		0	--	--	--	--
rs182938294^1,2		--	119643807(+)	`GTTTCC/TTAGAT`	1	--	ds500¹		0	--	--	--	--
rs76496824^1,2	C,F	--	119643863(+)	`TGTTTT/CCCTGA`	1	--	ds500¹		1		WA	118
rs139545317^1,2		--	119643968(+)	`AATAAA/GTCTAC`	1	--	ds500¹		0	--	--	--	--
rs149722407^1,2		--	119643989(+)	`TATACA/GAAGTG`	1	--	ut3¹		0	--	--	--	--
rs186928596^1,2		--	119644000(+)	`ATTTAC/TTGATA`	1	--	ut3¹		0	--	--	--	--
rs146746449^1,2		--	119644046(+)	`CAAAAC/TTGTAC`	1	--	ut3¹		0	--	--	--	--
rs191831989^1,2		--	119644055(+)	`ACAAAC/GAACCA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEC24D (119643978 - 119759838 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SEC24D
2 CNVs: 3511 51227

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC24D

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SEC24D for disorders           About GeneDecksing

OMIM gene information: 607186    OMIM disorders: --

4 diseases for SEC24D:    About MalaCards

liddle syndrome alcohol dependence alcoholism malaria

1 disease from the University of Copenhagen DISEASES database for SEC24D:

Liddle syndrome

Human Genome Epidemiology (HuGE) Navigator: SEC24D (2 documents)

Export disorders for SEC24D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SEC24D gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with SEC24D)

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world of online information

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2, 3} Nagase T.... Ohara O. (1998)
A family of mammalian proteins homologous to yeast Sec24p. (PubMed id 10329445)^{1, 2} Tang B.L....Hong W. (1999)
Sec24 proteins and sorting at the endoplasmic reticulum. (PubMed id 10075675)^{1, 3} Pagano A....Paccaud J.P. (1999)
Selective export of human GPI-anchored proteins from the endoplasmic reticulum. (PubMed id 20427317)^{2, 9} Bonnon C....Hauri H.P. (2010)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A triple arg motif mediates a(2B)-adrenergic receptor interaction with Sec24C/D and export. (PubMed id 22404651)¹ Dong C....Wu G. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9871	HGNC: 10706	AceView: SEC24D	Ensembl:ENSG00000150961	euGenes: HUgn9871
ECgene: SEC24D	Kegg: 9871	H-InvDB: SEC24D

(According to HUGE)
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HUGE: KIAA0755

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEC24D	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEC24D gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEC24D gene:
Search GeneIP for patents involving SEC24D

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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SEC24 family, member D (S. cerevisiae)

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SEC24D Gene

SEC24 family, member D (S. cerevisiae)

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