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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEC24C Gene

protein-coding GIFtS: 61
GCID: GC10P075504

SEC24 family, member C (S. cerevisiae)

(Previous names: SEC24 (S. cerevisiae) related gene family, member C )

Explore 2 diseases affiliated with
SEC24C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SEC24 Family, Member C (S. Cerevisiae)¹ ²
KIAA0079¹ ³
SEC24-Related Protein C² ³
SEC24 (S. Cerevisiae) Related Gene Family, Member C¹
Protein Transport Protein Sec24C²
SEC24 Related Gene Family, Member C²

External Ids:	HGNC: 10705¹	Entrez Gene: 9632²	Ensembl: ENSG00000176986⁷	OMIM: 607185⁵	UniProtKB: P53992³

Export aliases for SEC24C gene to outside databases

Previous GC identifers: GC10P074282 GC10P074607 GC10P075396 GC10P074848 GC10P075174 GC10P069499

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC24C:

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in

vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein

complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle,

as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein

have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992

Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic

reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane,

and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for SEC24C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEC24C gene promoter:
NF-YA MyoD PPAR-alpha NF-YB CBF-A CBF-B CP1A NF-Y CBF(2) En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEC24C promoter sequence

Search SABiosciences Chromatin IP Primers for SEC24C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC24C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2 Ensembl cytogenetic band: 10q22.2 HGNC cytogenetic band: 10q22

SEC24C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC24C gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P075504: view genomic region (about GC identifiers)

Start:	75,504,120 bp from pter	End:	75,531,919 bp from pter
Size:	27,800 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992 (See protein sequence)

Recommended Name: Protein transport protein Sec24C

Size: 1094 amino acids; 118325 Da

Subunit: Interacts with SLC6A4 (By similarity). COPII is composed of at least five proteins: the Sec23/24 complex, the

Sec13/31 complex and Sar1. SEC24C is capable of forming heterodimers with SEC24A. Interacts with TMED2 and TMED10

Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane (Potential). Golgi

apparatus membrane (Potential)

Sequence caution: Sequence=BAA07558.2; Type=Frameshift; Positions=1041;

1 PDB 3D structure from and Proteopedia for SEC24C:

3EH2 (3D)

Secondary accessions: Q8WV25

Explore the universe of human proteins at neXtProt for SEC24C: NX_P53992

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53992

SEC24C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004913.2 NP_940999.1

ENSEMBL proteins:

ENSP00000437000 ENSP00000321845 ENSP00000343405 ENSP00000402913 ENSP00000446333

ENSP00000446174 ENSP00000445023

Reactome Protein details: P53992
Human Recombinant Protein Products:

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	Novus Biologicals SEC24C Protein Novus Biologicals SEC24C Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEC24C

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005829	cytosol	TAS	--

SEC24C for ontologies About GeneDecksing

SEC24C Antibody Products:

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Assay Products for SEC24C:

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	Uscn ELISAs and CLIAs for SEC24C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEC24C for domains About GeneDecksing

5 InterPro domains/families:

IPR006900 Sec23/24_helical_dom

IPR012990 Sec23_24_beta_S

IPR006896 Sec23/24_trunk_dom

IPR006895 Znf_Sec23_Sec24

IPR007123 Gelsolin_dom

Graphical View of Domain Structure for InterPro Entry P53992

ProtoNet protein and cluster: P53992

3 Blocks protein families:

IPB006895 Sec23/Sec24 zinc finger

IPB006896 Sec23/Sec24 trunk domain

IPB006900 Sec23/Sec24 helical domain

UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992

Similarity: Belongs to the SEC23/SEC24 family. SEC24 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992

Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic

reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane,

and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Genatlas biochemistry entry for SEC24C:

SEC24 (S. cerevisiae) related gene family, member C

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEC24C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC24C
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24C (see all 49):
		hsa-let-7d hsa-miR-25 hsa-miR-4267 hsa-let-7g hsa-miR-149 hsa-let-7a hsa-miR-92b hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: SEC24C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC24C (see all 7) OriGene shRNA RFP: SEC24C OriGene siRNA: SEC24C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC24C

Gene Editing
Products:

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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24C (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24C (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SEC24C (NM_004922)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEC24C
		Search LifeMap BioReagents cell lines for SEC24C

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24C

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IPI	18692470
GO:0008270	zinc ion binding	IEA	--

SEC24C for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

COPII (Coat Protein 2) Mediated Vesicle Transport

COPII (Coat Protein 2) Mediated Vesicle Transport	1.00	SREBP1A/1C/2:SCAP Transits to the Golgi	0.50
ER to Golgi Transport	1.00	Delta508-CFTR traffic / ER-to-Golgi in CF	0.36
SREBP1A/1C/2:SCAP Binds CopII Coat Complex	0.50	Normal wtCFTR traffic / ER-to-Golgi	0.36

Clathrin-dependent protein traffic

	Clathrin-dependent protein traffic	1.00			wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)	0.37
	Transport_Clathrin-coated vesicle cycle	0.66

Asparagine N-linked glycosylation

	Asparagine N-linked glycosylation	1.00			Metabolism of proteins	0.15
	Post-translational protein modification	0.44

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

1.00

SREBP signalling

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SEC24C

Clathrin-dependent protein traffic

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC24C

SREBP Proteolysis

1 Cell Signaling Technology (CST) Pathway for SEC24C

Cytoskeletal Signaling

4 GeneGo (Thomson Reuters) Pathways for SEC24C

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Delta508-CFTR traffic / ER-to-Golgi in CF
	Normal wtCFTR traffic / ER-to-Golgi
	Transport Clathrin-coated vesicle cycle

1 BioSystems Pathway for SEC24C

SREBP signalling

5/19 Reactome Pathways for SEC24C (see all 19)

	SREBP2:SCAP Binds CopII Coat Complex
	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
	Membrane Trafficking
	Metabolism
	COPII (Coat Protein 2) Mediated Vesicle Transport

1 Kegg Pathway (Kegg details for SEC24C):

Protein processing in endoplasmic reticulum

SEC24C for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEC24C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/610 Interacting proteins for SEC24C (P53992^{1, 2, 3} ENSP00000321845⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 610)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MIA3	Q5JRA6²^,³, ENSP00000340900⁴	MINT-7217922 I2D: score=1 STRING: ENSP00000340900
SEC23A	Q15436¹^,²^,³, ENSP00000306881⁴	EBI-81134,EBI-81088 MINT-7947479 I2D: score=3 STRING: ENSP00000306881
CDC37	Q16543³, ENSP00000222005⁴	I2D: score=1 STRING: ENSP00000222005
COPG2	Q9UBF2², ENSP00000393912⁴	MINT-7947479 STRING: ENSP00000393912
SEC23B	Q15437³, ENSP00000262544⁴	I2D: score=4 STRING: ENSP00000262544

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0006886	intracellular protein transport	IEA	--
GO:0006888	ER to Golgi vesicle-mediated transport	TAS	--
GO:0016044	cellular membrane organization	TAS	--
GO:0018279	protein N-linked glycosylation via asparagine	TAS	--

SEC24C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEC24C
Search CenterWatch for drugs/clinical trials and news about SEC24C / SC24C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEC24C gene (2 alternative transcripts):

NM_004922.3 NM_198597.2

Unigene Cluster for SEC24C:

SEC24 family, member C (S. cerevisiae)

Hs.81964 [show with all ESTs]

Unigene Representative Sequence: AL832110

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000465076 ENST00000345254(uc010qkn.2 uc009xrj.2 uc001jux.3 uc010qko.2 uc010qkq.2)

ENST00000339365(uc001juw.3 uc010qkp.2) ENST00000477008 ENST00000496827

ENST00000411652 ENST00000546025 ENST00000535742 ENST00000540668

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEC24C Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC24C
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24C (see all 49):
		hsa-let-7d hsa-miR-25 hsa-miR-4267 hsa-let-7g hsa-miR-149 hsa-let-7a hsa-miR-92b hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: SEC24C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC24C (see all 7) OriGene shRNA RFP: SEC24C OriGene siRNA: SEC24C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC24C

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24C (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24C (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SEC24C (NM_004922)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC24C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC24C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEC24C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC24C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC24C

Additional cDNA sequence:

AK098512.1 AK126671.1 AK298598.1 AK299826.1 AK303085.1 AK309918.1 AK316451.1 AL832110.1

BC018928.2 D38555.1

21 DOTS entries:

DT.453811 DT.92446143 DT.75188821 DT.97799630 DT.100694142 DT.95174703 DT.100818493 DT.87015860

DT.121302229 DT.95128223 DT.100705349 DT.92446145 DT.95258603 DT.100818486 DT.101973696 DT.418507

DT.427977 DT.92446142 DT.92446175 DT.95258606 DT.121302198

24/292 AceView cDNA sequences (see all 292):

AA262319 BM966952 F31338 CA443438 BQ722013 CA396439 BU180505 AA928412

BP353055 CA448456 AI925366 AA694487 AI990404 BU527005 NM_198597 CD672194

BQ222474 CA445963 NM_173540 BC036037 CF144056 CD366442 BM829011 BM457859

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SEC24C (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·
SP1:							-						-																		-
SP2:													-																		-
SP3:							-						-						-
SP4:											-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:

ExUns:	19b	·	19c	^	20a	·	20b	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27
SP1:
SP2:
SP3:
SP4:	-		-
SP5:			-

ECgene alternative splicing isoforms for SEC24C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEC24C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTGCTGAT

About this image
See SEC24C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC24C

SOURCE GeneReport for Unigene cluster: Hs.81964

UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for SEC24C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC24C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEC24C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC24C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC24C

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC24C gene from 9/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEC24C¹	SEC24 family, member C (S. cerevisiae)	71.72(n) 79.6(a)		423742 XM_421617.2 XP_421617.1
lizard (Anolis carolinensis)	Reptilia	SEC24C⁶	--	71(a)	1 ↔ 1	GL343196.1(1222839-1266575)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3433²	Xenopus laevis transcribed sequence with moderate similarity to protein refNP_004913.1 (H.sapiens) Sec24-related protein C; SEC24 (S. cerevisiae) related gene family, member C; SEC24 (S. cerevisiae) homolog C; protein transport protein Sec24C [Homo sapi less	72.97(n)		AW641035.1
zebrafish (Danio rerio)	Actinopterygii	sec24c¹	SEC24 family, member C (S. cerevisiae)	67.22(n) 69.89(a)		571870 XM_695505.5 XP_700597.5
fruit fly (Drosophila melanogaster)	Insecta	CG10882³ gho¹	serine-type endopeptidase³ ghost¹	52(a)³ 53.09(n)¹ 50.42(a)¹		22D5³ 33409¹ NM_134820.2¹ NP_608664.2¹
worm (Caenorhabditis elegans)	Secernentea	sec-24.1^{1 , 3}	Yeast hypothetical YIK9 protein like³ Protein SEC-24.1¹	45(a)³ 48.49(n)¹ 44.41(a)¹		IV(11562517-11563694)³ 178078¹ NM_069777.2¹ NP_502178.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SFB3(YHR098C)⁴ SFB3¹	Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p less⁴ Sfb3p¹	42.08(n)¹ 27.92(a)¹		8(301934-299145)⁴ 856498^{1, 4} NP_011966.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	CEF⁶ AT4G32640⁶	sec24-like transport protein	29(a) 28(a)	many ↔ many many ↔ many	3(16011621-16020254) 4(15742001-15750862)
rice (Oryza sativa)	Liliopsida	-- --	protein transport protein, putative, expressed retrotransposon protein, putative, unclassified, e...	36(a) 28(a)	many ↔ many many ↔ many	11(16460663-16472036) 12(13813000-13827130)

ENSEMBL Gene Tree for SEC24C (if available)
TreeFam Gene Tree for SEC24C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEC24C gene

SEC24A² SEC24D² SEC24B²

3 SIMAP similar genes for SEC24C using alignment to 5 protein entries: SC24C_HUMAN (see all proteins):

SEC24D SEC24A SEC24B

SEC24C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs146875811^1,2	--	75502163(+)	`CCCAGC/TACTTT`	2	--	us2k¹		0	--	--	--	--
rs184861423^1,2	--	75502175(+)	`GGAGGA/CCAAGG`	2	--	us2k¹		0	--	--	--	--
rs111610563^1,2	--	75502339(+)	`GGAGGT/CGGAAG`	2	--	us2k¹		1		CSA	1
rs142962953^1,2	--	75502377(+)	`CACTCC/TGGCCT`	2	--	us2k¹		0	--	--	--	--
rs144697427^1,2	--	75502414(+)	`CAAAAC/TAGAGG`	2	--	us2k¹		0	--	--	--	--
rs148107877^1,2	--	75502552(+)	`CAATAA/TTATGA`	2	--	us2k¹		0	--	--	--	--
rs188932746^1,2	--	75502758(+)	`ATTAGC/TCTCCC`	2	--	us2k¹		0	--	--	--	--
rs141917441^1,2	--	75502803(+)	`TTGGCA/GAGTAG`	2	--	us2k¹		0	--	--	--	--
rs181706382^1,2	--	75503051(+)	`GACTCC/TTGGAG`	2	--	us2k¹		0	--	--	--	--
rs150769444^1,2	--	75503140(+)	`CCAGGC/TAAGAA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEC24C (75504120 - 75531919 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEC24C: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC24C

DNA2.0 Custom Variant and Variant Library Synthesis for SEC24C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SEC24C for disorders           About GeneDecksing

OMIM gene information: 607185    OMIM disorders: --

2 diseases for SEC24C:    About MalaCards

alzheimer's disease malaria

Human Genome Epidemiology (HuGE) Navigator: SEC24C (1 document)

Export disorders for SEC24C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SEC24C gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with SEC24C)

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Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p. (PubMed id 10214955)^{1, 2, 3} Tani K.... Tagaya M. (1999)
Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)^{1, 2, 3} Nomura N....Tabata S. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A family of mammalian proteins homologous to yeast Sec24p. (PubMed id 10329445)^{1, 2} Tang B.L....Hong W. (1999)
Sec24 proteins and sorting at the endoplasmic reticulum. (PubMed id 10075675)^{1, 2} Pagano A....Paccaud J.P. (1999)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A triple arg motif mediates a(2B)-adrenergic receptor interaction with Sec24C/D and export. (PubMed id 22404651)¹ Dong C....Wu G. (2012)
A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)¹ Long P....Rose S. (2012)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9632	HGNC: 10705	AceView: SEC24CandFUT11	Ensembl:ENSG00000176986	euGenes: HUgn9632
ECgene: SEC24C	Kegg: 9632	H-InvDB: SEC24C

(According to HUGE)
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HUGE: KIAA0079

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEC24C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEC24C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEC24C gene:
Search GeneIP for patents involving SEC24C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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SEC24C Gene

SEC24 family, member C (S. cerevisiae)

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SEC24C Gene

SEC24 family, member C (S. cerevisiae)

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