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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC24C Gene

protein-coding   GIFtS: 64
GCID: GC10P075504

SEC24 Family, Member C (S. Cerevisiae)

(Previous names: SEC24 (S. cerevisiae) related gene family, member C)
Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SEC24 Family, Member C (S. Cerevisiae)1 2
SEC24-Related Protein C2 3
SEC24 (S. Cerevisiae) Related Gene Family, Member C1
Protein Transport Protein Sec24C2
SEC24 Related Gene Family, Member C2
KIAA00793

External Ids:    HGNC: 107051   Entrez Gene: 96322   Ensembl: ENSG000001769867   OMIM: 6071855   UniProtKB: P539923   

Export aliases for SEC24C gene to outside databases

Previous GC identifers: GC10P074282 GC10P074607 GC10P075396 GC10P074848 GC10P075174 GC10P069499


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC24C Gene:
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved
in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat
protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping
the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding
the same protein have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEC24C Gene: 
SEC24C (SEC24 family, member C (S. cerevisiae)) is a protein-coding gene. Diseases associated with SEC24C include alzheimer's disease, and among its related super-pathways are COPII (Coat Protein 2) Mediated Vesicle Transport and Clathrin-dependent protein traffic. GO annotations related to this gene include molecular_function and zinc ion binding. An important paralog of this gene is SEC24A.

UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992
Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma
membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for SEC24C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC24C gene promoter:
         NF-YA   MyoD   PPAR-alpha   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC24C promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC24C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC24C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22

SEC24C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC24C gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P075504:  view genomic region     (about GC identifiers)

Start:
75,504,120 bp from pter      End:
75,531,933 bp from pter
Size:
27,814 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992 (See protein sequence)
Recommended Name: Protein transport protein Sec24C  
Size: 1094 amino acids; 118325 Da
Subunit: Interacts with SLC6A4 (By similarity). COPII is composed of at least five proteins: the Sec23/24 complex,
the Sec13/31 complex and Sar1. SEC24C is capable of forming heterodimers with SEC24A. Interacts with TMED2 and
TMED10
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane (Potential). Golgi
apparatus membrane (Potential)
Sequence caution: Sequence=BAA07558.2; Type=Frameshift; Positions=1041;
1 PDB 3D structure from and Proteopedia for SEC24C:
3EH2 (3D)    
Secondary accessions: Q8WV25

Explore the universe of human proteins at neXtProt for SEC24C: NX_P53992

Explore proteomics data for SEC24C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53992

  • SEC24C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEC24C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004913.2  NP_940999.1  

    ENSEMBL proteins: 
     ENSP00000437000   ENSP00000321845   ENSP00000343405   ENSP00000402913   ENSP00000446333  
     ENSP00000446174   ENSP00000445023  
    Reactome Protein details: P53992
    Human Recombinant Protein Products for SEC24C: 
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    Novus Biologicals SEC24C Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC24C 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005829cytosol TAS--

    SEC24C for ontologies           About GeneDecksing



    SEC24C Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR006900 Sec23/24_helical_dom
     IPR012990 Sec23_24_beta_S
     IPR006896 Sec23/24_trunk_dom
     IPR006895 Znf_Sec23_Sec24
     IPR007123 Gelsolin_dom

    Graphical View of Domain Structure for InterPro Entry P53992

    ProtoNet protein and cluster: P53992

    3 Blocks protein domains:
    IPB006895 Sec23/Sec24 zinc finger
    IPB006896 Sec23/Sec24 trunk domain
    IPB006900 Sec23/Sec24 helical domain


    UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992
    Similarity: Belongs to the SEC23/SEC24 family. SEC24 subfamily


    SEC24C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC24C_HUMAN, P53992
    Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
    reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma
    membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

         Genatlas biochemistry entry for SEC24C:
    SEC24 (S. cerevisiae) related gene family, member C

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI10075675
    GO:0008270zinc ion binding IEA--
         
    SEC24C for ontologies           About GeneDecksing


    Animal Models:
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    hsa-let-7d hsa-miR-25 hsa-miR-4267 hsa-let-7g hsa-miR-149 hsa-let-7a hsa-miR-92b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidSEC24C 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEC24C About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1COPII (Coat Protein 2) Mediated Vesicle Transport
    COPII (Coat Protein 2) Mediated Vesicle Transport0.36
    ER to Golgi Transport0.36
    Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC0.31
    Normal wtCFTR traffic / ER-to-Golgi 0.36
    2Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.67
    SREBP signalling0.37
    4Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SEC24C
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC24C
        SREBP Proteolysis

    1 Cell Signaling Technology (CST) Pathway for SEC24C
        Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for SEC24C
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SEC24C
        SREBP signalling

    5/18        Reactome Pathways for SEC24C (see all 18)
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Membrane Trafficking
    Metabolism
    COPII (Coat Protein 2) Mediated Vesicle Transport
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)


    1         Kegg Pathway  (Kegg details for SEC24C):
        Protein processing in endoplasmic reticulum


    SEC24C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC24C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/637 Interacting proteins for SEC24C (P539921, 2, 3 ENSP000003218454) via UniProtKB, MINT, STRING, and/or I2D (see all 637)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MIA3Q5JRA62, 3, ENSP000003409004MINT-7217922 I2D: score=1 STRING: ENSP00000340900
    SEC23AQ154361, 2, 3, ENSP000003068814EBI-81134,EBI-81088 MINT-7947479 I2D: score=3 STRING: ENSP00000306881
    CDC37Q165433, ENSP000002220054I2D: score=1 STRING: ENSP00000222005
    COPG2Q9UBF22, ENSP000003939124MINT-7947479 STRING: ENSP00000393912
    SEC23BQ154373, ENSP000002625444I2D: score=4 STRING: ENSP00000262544
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    SEC24C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC24C (SC24C)

    Search CenterWatch for drugs/clinical trials and news about SEC24C / SC24C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC24C gene (2 alternative transcripts): 
    NM_004922.3  NM_198597.2  

    Unigene Cluster for SEC24C:

    SEC24 family, member C (S. cerevisiae)
    Hs.81964  [show with all ESTs]
    Unigene Representative Sequence: AL832110
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465076 ENST00000345254(uc010qkn.2 uc009xrj.2 uc001jux.3 uc010qko.2 uc010qkq.2)
    ENST00000339365(uc001juw.3 uc010qkp.2) ENST00000477008 ENST00000496827
    ENST00000411652 ENST00000546025 ENST00000535742 ENST00000540668

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    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24C (see all 49):
    hsa-let-7d hsa-miR-25 hsa-miR-4267 hsa-let-7g hsa-miR-149 hsa-let-7a hsa-miR-92b hsa-miR-761
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    Additional mRNA sequence: 

    AK098512.1 AK126671.1 AK298598.1 AK299826.1 AK303085.1 AK309918.1 AK316451.1 AL832110.1 
    BC018928.2 D38555.1 

    21 DOTS entries:

    DT.453811  DT.92446143  DT.75188821  DT.97799630  DT.100694142  DT.95174703  DT.100818493  DT.87015860 
    DT.121302229  DT.95128223  DT.100705349  DT.92446145  DT.95258603  DT.100818486  DT.101973696  DT.418507 
    DT.427977  DT.92446142  DT.92446175  DT.95258606  DT.121302198 

    24/292 AceView cDNA sequences (see all 292):

    BC036037 BM829011 BI833237 BP353055 CK000598 AL545537 AI309532 BX384201 
    BM457859 BE292860 CA443438 AA262319 BQ222474 NM_004922 BU527005 BU737345 
    AW449995 CD672194 BG253956 F31338 BU161209 NM_198597 AI921038 BE674456 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SEC24C (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                    -                 -                                                     -                                                               
    SP2:                                      -                                                     -                                                               
    SP3:                    -                 -                 -                                                                                                   
    SP4:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:  -     -                                                               
    SP5:        -                                                               


    ECgene alternative splicing isoforms for SEC24C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC24C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGCTGAT
    SEC24C Expression
    About this image


    See SEC24C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC24C

    SOURCE GeneReport for Unigene cluster: Hs.81964

    UniProtKB/Swiss-Prot: SC24C_HUMAN, P53992
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC24C gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec24c1 , 5 Sec24 related gene family, member C (S. cerevisiae)1, 5 89.76(n)1
    92.6(a)1
      14 (11.53 cM)5
    2188111  NM_172596.21  NP_766184.21 
     206743215 
    chicken
    (Gallus gallus)
    Aves SEC24C1 SEC24 family, member C (S. cerevisiae) 71.72(n)
    79.6(a)
      423742  XM_421617.2  XP_421617.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC24C6
    SEC24 family, member C (S. cerevisiae)
    72(a)
    1 ↔ 1
    GL343196.1(1222810-1266575)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34332 Xenopus laevis transcribed sequence with moderate similarity more 72.97(n)    AW641035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sec24c1 SEC24 family, member C (S. cerevisiae) 67.22(n)
    69.89(a)
      571870  XM_695505.5  XP_700597.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108823
    gho1
    serine-type endopeptidase3
    ghost1
    52(a)3
    53.09(n)1
    50.42(a)1
      22D53
    334091  NM_134820.21  NP_608664.21 
    worm
    (Caenorhabditis elegans)
    Secernentea sec-24.11 , 3 Yeast hypothetical YIK9 protein like3
    Protein SEC-24.11
    45(a)3
    48.49(n)1
    44.41(a)1
      IV(11562517-11563694)3
    1780781  NM_069777.21  NP_502178.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SFB3(YHR098C)4
    SFB31
    Component of the Sec23p-Sfb3p heterodimer of the COPII more4
    Sfb3p1
    42.08(n)1
    27.92(a)1
      8(301934-299145)4
    8564981, 4  NP_011966.11, 4 


    ENSEMBL Gene Tree for SEC24C (if available)
    TreeFam Gene Tree for SEC24C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC24C gene
    SEC24A2  SEC24D2  SEC24B2  
    3 SIMAP similar genes for SEC24C using alignment to 5 protein entries:     SC24C_HUMAN (see all proteins):
    SEC24D    SEC24A    SEC24B

    SEC24C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/597 SNPs in SEC24C are shown (see all 597)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468758111,2
    C--75502163(+) CCCAGC/TACTTT 2 -- us2k10--------
    rs1848614231,2
    --75502175(+) GGAGGA/CCAAGG 2 -- us2k10--------
    rs1116105631,2
    F--75502339(+) GGAGGT/CGGAAG 2 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1429629531,2
    --75502377(+) CACTCC/TGGCCT 2 -- us2k10--------
    rs1446974271,2
    --75502414(+) CAAAAC/TAGAGG 2 -- us2k10--------
    rs1481078771,2
    --75502552(+) CAATAA/TTATGA 2 -- us2k10--------
    rs1889327461,2
    --75502758(+) ATTAGC/TCTCCC 2 -- us2k10--------
    rs1419174411,2
    --75502803(+) TTGGCA/GAGTAG 2 -- us2k10--------
    rs1817063821,2
    --75503051(+) GACTCC/TTGGAG 2 -- us2k10--------
    rs1507694441,2
    --75503140(+) CCAGGC/TAAGAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEC24C (75504120 - 75531933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SEC24C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv825468CNV Gain20364138
    nsv831912CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607185    OMIM disorders: --

    2 diseases for SEC24C:    About MalaCards
    alzheimer's disease    


    SEC24C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SEC24C
    Human Genome Epidemiology (HuGE) Navigator: SEC24C (1 document)

    Export disorders for SEC24C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC24C gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with SEC24C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p. (PubMed id 10214955)1, 2, 3 Tani K.... Tagaya M. (1999)
    2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N....Tabata S. (1994)
    3. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A family of mammalian proteins homologous to yeast Sec24p. (PubMed id 10329445)1, 2 Tang B.L....Hong W. (1999)
    6. Sec24 proteins and sorting at the endoplasmic reticulum. (PubMed id 10075675)1, 2 Pagano A....Paccaud J.P. (1999)
    7. Switching the clientele: a lysine residing in the C te rminus of the serotonin transporter specifies its preference for the coat protei n complex II component SEC24C. (PubMed id 23288844)1 Sucic S....Freissmuth M. (2013)
    8. A new class of endoplasmic reticulum export signal Phi XPhiXPhi for transmembrane proteins and its selective interaction with Sec24C. (PubMed id 23658022)1 Otsu W....Inaba M. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A triple arg motif mediates a(2B)-adrenergic receptor interaction with Sec24C/D and export. (PubMed id 22404651)1 Dong C....Wu G. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9632 HGNC: 10705 AceView: SEC24CandFUT11 Ensembl:ENSG00000176986 euGenes: HUgn9632
    ECgene: SEC24C Kegg: 9632 H-InvDB: SEC24C

    (According to HUGE)
    About This Section
    HUGE: KIAA0079

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC24C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC24C gene:
    Search GeneIP for patents involving SEC24C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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