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Aliases for SEC24B Gene

Aliases for SEC24B Gene

  • SEC24 Family Member B 2 3
  • SEC24 (S. Cerevisiae) Related Gene Family, Member B 2
  • SEC24 Family, Member B (S. Cerevisiae) 2
  • SEC24 Related Gene Family, Member B 3
  • Protein Transport Protein Sec24B 3
  • SEC24-Related Protein B 4
  • Secretory Protein 24 3
  • SEC24 3

External Ids for SEC24B Gene

Summaries for SEC24B Gene

Entrez Gene Summary for SEC24B Gene

  • The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC24B Gene

SEC24B (SEC24 Family Member B) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). GO annotations related to this gene include transporter activity. An important paralog of this gene is SEC24D.

UniProtKB/Swiss-Prot for SEC24B Gene

  • Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for SEC24B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC24B Gene

Genomics for SEC24B Gene

Genomic Location for SEC24B Gene

Start:
109,433,772 bp from pter
End:
109,540,896 bp from pter
Size:
107,125 bases
Orientation:
Plus strand

Genomic View for SEC24B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC24B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC24B Gene

Regulatory Elements for SEC24B Gene

Proteins for SEC24B Gene

  • Protein details for SEC24B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95487-SC24B_HUMAN
    Recommended name:
    Protein transport protein Sec24B
    Protein Accession:
    O95487
    Secondary Accessions:
    • B7ZKM8
    • B7ZKN4
    • Q0VG08

    Protein attributes for SEC24B Gene

    Size:
    1268 amino acids
    Molecular mass:
    137418 Da
    Quaternary structure:
    • COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1. SEC24B is capable of forming heterodimers with SEC24A. Interacts with RNF139. Interacts with TMED2 and TMED10. Interacts with CNIH4 (PubMed:24405750).
    SequenceCaution:
    • Sequence=CAA10335.1; Type=Frameshift; Positions=459, 483; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC24B Gene

    Alternative splice isoforms for SEC24B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC24B Gene

Proteomics data for SEC24B Gene at MOPED

Post-translational modifications for SEC24B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys625
  • Glycosylation at Ser139 and Ser149

Other Protein References for SEC24B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC24B Gene

Domains for SEC24B Gene

UniProtKB/Swiss-Prot:

SC24B_HUMAN
Family:
  • Belongs to the SEC23/SEC24 family. SEC24 subfamily.:
    • O95487
genes like me logo Genes that share domains with SEC24B: view

No data available for Gene Families for SEC24B Gene

Function for SEC24B Gene

Molecular function for SEC24B Gene

GENATLAS Biochemistry: SEC24 (S. cerevisiae) related gene family, member B
UniProtKB/Swiss-Prot Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Ontology (GO) - Molecular Function for SEC24B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 10075675
GO:0005515 protein binding IPI 19706601
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SEC24B: view
genes like me logo Genes that share phenotypes with SEC24B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC24B Gene

Localization for SEC24B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC24B Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane. Golgi apparatus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC24B Gene COMPARTMENTS Subcellular localization image for SEC24B gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
golgi apparatus 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SEC24B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0016020 membrane TAS 10075675
genes like me logo Genes that share ontologies with SEC24B: view

Pathways for SEC24B Gene

genes like me logo Genes that share pathways with SEC24B: view

Pathways by source for SEC24B Gene

1 Qiagen pathway for SEC24B Gene
1 Cell Signaling Technology pathway for SEC24B Gene

Gene Ontology (GO) - Biological Process for SEC24B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0002093 auditory receptor cell morphogenesis --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0003151 outflow tract morphogenesis IEA --
GO:0006886 intracellular protein transport IEA --
genes like me logo Genes that share ontologies with SEC24B: view

Transcripts for SEC24B Gene

Unigene Clusters for SEC24B Gene

SEC24 family, member B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC24B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13: - -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SEC24B Gene

GeneLoc Exon Structure for
SEC24B
ECgene alternative splicing isoforms for
SEC24B

Expression for SEC24B Gene

mRNA expression in normal human tissues for SEC24B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC24B Gene

SOURCE GeneReport for Unigene cluster for SEC24B Gene Hs.292472

mRNA Expression by UniProt/SwissProt for SEC24B Gene

O95487-SC24B_HUMAN
Tissue specificity: Expressed in fibroblasts, hepatocytes, and lymphocytes
genes like me logo Genes that share expressions with SEC24B: view

Orthologs for SEC24B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC24B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC24B 36
  • 98.16 (n)
  • 97.63 (a)
SEC24B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC24B 36
  • 91.19 (n)
  • 93.14 (a)
SEC24B 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC24B 36
  • 92.41 (n)
  • 93.15 (a)
SEC24B 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec24b 36
  • 83.37 (n)
  • 84.26 (a)
Sec24b 16
Sec24b 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC24B 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sec24b 36
  • 82.77 (n)
  • 84.09 (a)
chicken
(Gallus gallus)
Aves SEC24B 36
  • 76.27 (n)
  • 78.5 (a)
SEC24B 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC24B 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec24b 36
  • 68.87 (n)
  • 69.02 (a)
zebrafish
(Danio rerio)
Actinopterygii SEC24B 37
  • 62 (a)
OneToOne
wu:fa16f04 36
  • 67.11 (n)
  • 74.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec24 37
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-24.2 36
  • 51.94 (n)
  • 44.83 (a)
sec-24.2 37
  • 39 (a)
OneToMany
sec-24.2 38
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL239C 36
  • 46 (n)
  • 36.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC24 36
  • 45.75 (n)
  • 36.73 (a)
SEC24 37
  • 32 (a)
ManyToMany
SFB2 37
  • 32 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03729g 36
  • 47.98 (n)
  • 36.91 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.745 36
bread mold
(Neurospora crassa)
Ascomycetes NCU02391 36
  • 45.78 (n)
  • 37.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec24 36
  • 46.15 (n)
  • 35.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4768 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9300 37
  • 56 (a)
OneToMany
Species with no ortholog for SEC24B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC24B Gene

ENSEMBL:
Gene Tree for SEC24B (if available)
TreeFam:
Gene Tree for SEC24B (if available)

Paralogs for SEC24B Gene

Paralogs for SEC24B Gene

Selected SIMAP similar genes for SEC24B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC24B: view

Variants for SEC24B Gene

Sequence variations from dbSNP and Humsavar for SEC24B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs15821 -- 109,539,728(+) ATAAT(A/C)TGTCA utr-variant-3-prime
rs952100 -- 109,517,426(-) tactc(C/T)ctact intron-variant
rs1043659 -- 109,491,351(+) CACAA(A/G)CAGTG missense, reference
rs1396709 -- 109,457,532(+) tttat(A/G)tcaat intron-variant
rs1509314 -- 109,456,683(+) TAATA(C/T)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC24B Gene

Variant ID Type Subtype PubMed ID
nsv461613 CNV Gain 19166990
nsv4461 CNV Insertion 18451855
esv24031 CNV Loss 19812545
esv2677495 CNV Deletion 23128226
esv2667224 CNV Deletion 23128226
nsv525385 CNV Loss 19592680
nsv292772 CNV Insertion 16902084
esv270668 CNV Insertion 20981092
nsv4462 CNV Insertion 18451855

Relevant External Links for SEC24B Gene

HapMap Linkage Disequilibrium report
SEC24B
Human Gene Mutation Database (HGMD)
SEC24B

Disorders for SEC24B Gene

(1) University of Copenhagen DISEASES for SEC24B Gene

Relevant External Links for SEC24B

Genetic Association Database (GAD)
SEC24B
Human Genome Epidemiology (HuGE) Navigator
SEC24B
genes like me logo Genes that share disorders with SEC24B: view

No data available for UniProtKB/Swiss-Prot for SEC24B Gene

Publications for SEC24B Gene

  1. Sec24 proteins and sorting at the endoplasmic reticulum. (PMID: 10075675) Pagano A. … Paccaud J.-P. (J. Biol. Chem. 1999) 2 3 4 23
  2. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. (PMID: 20427317) Bonnon C. … Hauri H.P. (J. Cell Sci. 2010) 4 23
  3. A family of mammalian proteins homologous to yeast Sec24p. (PMID: 10329445) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1999) 2 3
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. (PMID: 19706601) Irisawa M. … Sato R. (J. Biol. Chem. 2009) 3 4

Products for SEC24B Gene

Sources for SEC24B Gene

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