Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEC24B Gene

Aliases for SEC24B Gene

  • SEC24 Homolog B, COPII Coat Complex Component 2 3 5
  • SEC24 (S. Cerevisiae) Related Gene Family, Member B 2
  • SEC24 Family, Member B (S. Cerevisiae) 2
  • SEC24 Related Gene Family, Member B 3
  • SEC24-Related Protein B 4
  • SEC24 Family Member B 2
  • Secretory Protein 24 3
  • SEC24 3

External Ids for SEC24B Gene

Previous GeneCards Identifiers for SEC24B Gene

  • GC04P110811
  • GC04P110664
  • GC04P110813
  • GC04P110712
  • GC04P110574
  • GC04P110354
  • GC04P106087

Summaries for SEC24B Gene

Entrez Gene Summary for SEC24B Gene

  • The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for SEC24B Gene

SEC24B (SEC24 Homolog B, COPII Coat Complex Component) is a Protein Coding gene. Diseases associated with SEC24B include neural tube defects. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transporter activity. An important paralog of this gene is SEC24D.

UniProtKB/Swiss-Prot for SEC24B Gene

  • Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Gene Wiki entry for SEC24B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC24B Gene

Genomics for SEC24B Gene

Regulatory Elements for SEC24B Gene

Promoters for SEC24B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC24B on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC24B Gene

Chromosome:
4
Start:
109,433,772 bp from pter
End:
109,540,896 bp from pter
Size:
107,125 bases
Orientation:
Plus strand

Genomic View for SEC24B Gene

Genes around SEC24B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC24B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC24B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC24B Gene

Proteins for SEC24B Gene

  • Protein details for SEC24B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95487-SC24B_HUMAN
    Recommended name:
    Protein transport protein Sec24B
    Protein Accession:
    O95487
    Secondary Accessions:
    • B7ZKM8
    • B7ZKN4
    • Q0VG08

    Protein attributes for SEC24B Gene

    Size:
    1268 amino acids
    Molecular mass:
    137418 Da
    Quaternary structure:
    • COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1. SEC24B is capable of forming heterodimers with SEC24A. Interacts with RNF139. Interacts with TMED2 and TMED10. Interacts with CNIH4 (PubMed:24405750).
    SequenceCaution:
    • Sequence=CAA10335.1; Type=Frameshift; Positions=459, 483; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC24B Gene

    Alternative splice isoforms for SEC24B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC24B Gene

Proteomics data for SEC24B Gene at MOPED

Post-translational modifications for SEC24B Gene

  • Glycosylation at Ser 139
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC24B Gene

No data available for DME Specific Peptides for SEC24B Gene

Domains & Families for SEC24B Gene

Suggested Antigen Peptide Sequences for SEC24B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95487

UniProtKB/Swiss-Prot:

SC24B_HUMAN :
  • Belongs to the SEC23/SEC24 family. SEC24 subfamily.
Family:
  • Belongs to the SEC23/SEC24 family. SEC24 subfamily.
genes like me logo Genes that share domains with SEC24B: view

No data available for Gene Families for SEC24B Gene

Function for SEC24B Gene

Molecular function for SEC24B Gene

GENATLAS Biochemistry:
SEC24 (S. cerevisiae) related gene family, member B
UniProtKB/Swiss-Prot Function:
Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
genes like me logo Genes that share phenotypes with SEC24B: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC24B Gene

Localization for SEC24B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC24B Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane. Golgi apparatus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC24B Gene COMPARTMENTS Subcellular localization image for SEC24B gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 4
nucleus 2

Gene Ontology (GO) - Cellular Components for SEC24B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 10075675
GO:0030127 COPII vesicle coat IEA --
genes like me logo Genes that share ontologies with SEC24B: view

Pathways & Interactions for SEC24B Gene

genes like me logo Genes that share pathways with SEC24B: view

Gene Ontology (GO) - Biological Process for SEC24B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002093 auditory receptor cell morphogenesis IEA --
GO:0003151 outflow tract morphogenesis IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0021747 cochlear nucleus development IEA --
genes like me logo Genes that share ontologies with SEC24B: view

No data available for SIGNOR curated interactions for SEC24B Gene

Drugs & Compounds for SEC24B Gene

No Compound Related Data Available

Transcripts for SEC24B Gene

Unigene Clusters for SEC24B Gene

SEC24 family, member B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC24B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13: - -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SEC24B Gene

GeneLoc Exon Structure for
SEC24B
ECgene alternative splicing isoforms for
SEC24B

Expression for SEC24B Gene

mRNA expression in normal human tissues for SEC24B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC24B Gene



SOURCE GeneReport for Unigene cluster for SEC24B Gene Hs.292472

mRNA Expression by UniProt/SwissProt for SEC24B Gene

O95487-SC24B_HUMAN
Tissue specificity: Expressed in fibroblasts, hepatocytes, and lymphocytes.
genes like me logo Genes that share expression patterns with SEC24B: view

Protein tissue co-expression partners for SEC24B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for SEC24B Gene

Orthologs for SEC24B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC24B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC24B 35
  • 91.19 (n)
  • 93.14 (a)
SEC24B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC24B 35
  • 92.41 (n)
  • 93.15 (a)
SEC24B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec24b 35
  • 83.37 (n)
  • 84.26 (a)
Sec24b 16
Sec24b 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC24B 35
  • 98.16 (n)
  • 97.63 (a)
SEC24B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec24b 35
  • 82.77 (n)
  • 84.09 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC24B 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves SEC24B 35
  • 76.27 (n)
  • 78.5 (a)
SEC24B 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC24B 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec24b 35
  • 68.87 (n)
  • 69.02 (a)
zebrafish
(Danio rerio)
Actinopterygii wu:fa16f04 35
  • 67.11 (n)
  • 74.42 (a)
SEC24B 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sec24 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-24.2 37
  • 42 (a)
sec-24.2 35
  • 51.94 (n)
  • 44.83 (a)
sec-24.2 36
  • 39 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL239C 35
  • 46 (n)
  • 36.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03729g 35
  • 47.98 (n)
  • 36.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC24 35
  • 45.75 (n)
  • 36.73 (a)
SEC24 36
  • 32 (a)
ManyToMany
SFB2 36
  • 32 (a)
ManyToMany
barley
(Hordeum vulgare)
Liliopsida Hv.745 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4768 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02391 35
  • 45.78 (n)
  • 37.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec24 35
  • 46.15 (n)
  • 35.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9300 36
  • 56 (a)
OneToMany
Species with no ortholog for SEC24B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC24B Gene

ENSEMBL:
Gene Tree for SEC24B (if available)
TreeFam:
Gene Tree for SEC24B (if available)

Paralogs for SEC24B Gene

Paralogs for SEC24B Gene

(3) SIMAP similar genes for SEC24B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC24B: view

Variants for SEC24B Gene

Sequence variations from dbSNP and Humsavar for SEC24B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs35705351 - 109,494,735(+) AATGG(C/G)TAAGC reference, missense
rs15821 -- 109,539,728(+) ATAAT(A/C)TGTCA utr-variant-3-prime
rs1396709 -- 109,457,532(+) tttat(A/G)tcaat intron-variant
rs1509314 -- 109,456,683(+) TAATA(C/T)GTTGA intron-variant
rs1509315 -- 109,457,126(+) CCCCA(A/T)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC24B Gene

Variant ID Type Subtype PubMed ID
nsv461613 CNV Gain 19166990
nsv4461 CNV Insertion 18451855
esv24031 CNV Loss 19812545
esv2677495 CNV Deletion 23128226
esv2667224 CNV Deletion 23128226
nsv525385 CNV Loss 19592680
nsv292772 CNV Insertion 16902084
esv270668 CNV Insertion 20981092
nsv4462 CNV Insertion 18451855

Variation tolerance for SEC24B Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC24B Gene

HapMap Linkage Disequilibrium report
SEC24B
Human Gene Mutation Database (HGMD)
SEC24B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC24B Gene

Disorders for SEC24B Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEC24B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • spina bifida
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SEC24B

Genetic Association Database (GAD)
SEC24B
Human Genome Epidemiology (HuGE) Navigator
SEC24B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC24B
genes like me logo Genes that share disorders with SEC24B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEC24B Gene

Publications for SEC24B Gene

  1. Sec24 proteins and sorting at the endoplasmic reticulum. (PMID: 10075675) Pagano A. … Paccaud J.-P. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. A family of mammalian proteins homologous to yeast Sec24p. (PMID: 10329445) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1999) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SEC24B Gene

Sources for SEC24B Gene

Back to Top

Content