Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC24B Gene

protein-coding   GIFtS: 60
GCID: GC04P110354

SEC24 family, member B (S. cerevisiae)

(Previous names: SEC24 (S. cerevisiae) related gene family, member B, SEC24...)
 Explore 7 diseases affiliated with
SEC24B via our new
 Human Malady Compendium 
Biological research products
for SEC24B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SEC24 Family, Member B (S. Cerevisiae)1 2     SEC242
SEC24-Related Protein B2 3     Protein Transport Protein Sec24B2
SEC24 (S. Cerevisiae) Related Gene Family, Member B1     SEC24 Related Gene Family, Member B2
SEC24 Related Gene Family, Member B (S. Cerevisiae)1     Secretory Protein 242

External Ids:    HGNC: 107041   Entrez Gene: 104272   Ensembl: ENSG000001388027   OMIM: 6071845   UniProtKB: O954873   

Export aliases for SEC24B gene to outside databases

Previous GC identifers: GC04P110811 GC04P110664 GC04P110813 GC04P110712 GC04P110574 GC04P106087


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC24B:
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in
vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein
complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the
vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SC24B_HUMAN, O95487
Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane,
and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for SEC24B


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC24B gene promoter:
         C/EBPbeta   ISGF-3   Arnt   GATA-2   CREB   HEN1   POU2F1   E2F-1   E2F   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC24B promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC24B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC24B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

SEC24B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC24B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P110354:  view genomic region     (about GC identifiers)

Start:
110,354,928 bp from pter      End:
110,461,615 bp from pter
Size:
106,688 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SC24B_HUMAN, O95487 (See protein sequence)
Recommended Name: Protein transport protein Sec24B  
Size: 1268 amino acids; 137418 Da
Subunit: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1. SEC24B is
capable of forming heterodimers with SEC24A. Interacts with RNF139. Interacts with TMED2 and TMED10
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane (Potential). Golgi
apparatus membrane (Potential). Golgi apparatus membrane (By similarity)
Sequence caution: Sequence=CAA10335.1; Type=Frameshift; Positions=459, 483;
1 PDB 3D structure from and Proteopedia for SEC24B:
3EH1 (3D)    
Secondary accessions: B7ZKN4 Q0VG08
Alternative splicing: 2 isoforms:  O95487-1   O95487-2   

Explore the universe of human proteins at neXtProt for SEC24B: NX_O95487

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95487

  • SEC24B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036199.1  NP_006314.2  

    ENSEMBL proteins: 
     ENSP00000428564   ENSP00000382051   ENSP00000265175  
    Reactome Protein details: O95487
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SEC24B
    OriGene Protein Over-expression Lysate: SEC24B
    OriGene Custom Protein Services for SEC24B 
    GenScript Custom Purified and Recombinant Proteins Services for SEC24B
    Novus Biologicals SEC24B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEC24B

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005829cytosol TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0016020membrane TAS10075675


    SEC24B for ontologies           About GeneDecksing



    SEC24B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SEC24B 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEC24B 
    GenScript Custom Superior Antibodies Services for SEC24B
    Novus Biologicals SEC24B Antibody
    Search for Antibodies for SEC24B at Abcam  
    Uscn Antibodies for SEC24B
    Search ThermoFisher Antibodies for SEC24B

    Assay Products for SEC24B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEC24B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SEC24B


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SEC24B for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR006900 Sec23/24_helical_dom
     IPR012990 Sec23_24_beta_S
     IPR006896 Sec23/24_trunk_dom
     IPR006895 Znf_Sec23_Sec24
     IPR007123 Gelsolin_dom

    Graphical View of Domain Structure for InterPro Entry O95487

    ProtoNet protein and cluster: O95487

    5 Blocks protein families:
    IPB000425 MIP family
    IPB006895 Sec23/Sec24 zinc finger
    IPB006896 Sec23/Sec24 trunk domain
    IPB006900 Sec23/Sec24 helical domain
    IPB007123 Gelsolin region


    UniProtKB/Swiss-Prot: SC24B_HUMAN, O95487
    Similarity: Belongs to the SEC23/SEC24 family. SEC24 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SC24B_HUMAN, O95487
    Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
    reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane,
    and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

         Genatlas biochemistry entry for SEC24B:
    SEC24 (S. cerevisiae) related gene family, member B

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): SEC24B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC24B
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24B:
    hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidSEC24B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC24B (see all 7)
    OriGene shRNA RFP: SEC24B
    OriGene siRNA: SEC24B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC24B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC24B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24B (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24B (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SEC24B (NM_006323)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC24B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEC24B
    Search LifeMap BioReagents cell lines for SEC24B

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24B

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS10075675
    GO:0005515protein binding IPI19706601
    GO:0008270zinc ion binding IEA--


    SEC24B for ontologies           About GeneDecksing


    Animal Models:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sec24b):
     cardiovascular system  embryogenesis  growth/size  hearing/vestibular/ear  mortality/aging 
     nervous system  respiratory system  vision/eye 

    SEC24B for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1COPII (Coat Protein 2) Mediated Vesicle Transport
    COPII (Coat Protein 2) Mediated Vesicle Transport1.00
    SREBP1A/1C/2:SCAP Transits to the Golgi0.50
    ER to Golgi Transport1.00
    Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    SREBP1A/1C/2:SCAP Binds CopII Coat Complex0.50
    Normal wtCFTR traffic / ER-to-Golgi 0.36
    2Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic1.00
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport_Clathrin-coated vesicle cycle0.66
    3Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation1.00
    Metabolism of proteins0.15
    Post-translational protein modification0.44
    4Immune System
    Immune System1.00
    Adaptive Immune System0.59
    5Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)1.00
    SREBP signalling0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SEC24B
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC24B
        SREBP Proteolysis

    1 Cell Signaling Technology (CST) Pathway for SEC24B
        Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for SEC24B
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SEC24B 
        SREBP signalling

    5/17        Reactome Pathways for SEC24B (see all 17)
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Membrane Trafficking
    Metabolism
    COPII (Coat Protein 2) Mediated Vesicle Transport
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)


    1         Kegg Pathway  (Kegg details for SEC24B):
        Protein processing in endoplasmic reticulum


    SEC24B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC24B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/104 Interacting proteins for SEC24B (O954873 ENSP000002651754) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYCO1Q9BQS83, ENSP000002961374I2D: score=3 STRING: ENSP00000296137
    TMED2Q153633, ENSP000002622254I2D: score=3 STRING: ENSP00000262225
    SEC13P557353, ENSP000003121224I2D: score=2 STRING: ENSP00000312122
    MLST8Q9BVC43, ENSP000003718884I2D: score=1 STRING: ENSP00000371888
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--
    GO:0016044cellular membrane organization TAS--
    GO:0016192vesicle-mediated transport TAS10075675


    SEC24B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC24B
    Search CenterWatch for drugs/clinical trials and news about SEC24B / SC24B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC24B gene (2 alternative transcripts): 
    NM_001042734.1  NM_006323.2  

    Unigene Cluster for SEC24B:

    SEC24 family, member B (S. cerevisiae)
    Hs.292472  [show with all ESTs]
    Unigene Representative Sequence: AJ131245
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504968 ENST00000399100 ENST00000265175(uc003hzk.3 uc003hzl.3 uc011cfp.2 uc011cfq.2 uc011cfr.2)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): SEC24B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC24B
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24B:
    hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidSEC24B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC24B (see all 7)
    OriGene shRNA RFP: SEC24B
    OriGene siRNA: SEC24B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC24B
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24B (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24B (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SEC24B (NM_006323)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC24B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24B 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC24B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SEC24B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC24B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC24B

    Additional cDNA sequence: 

    AJ131245.1 AK300278.1 AK304234.1 BC040137.1 BC117135.1 BC143268.1 BC143269.1 BC143276.1 

    9 DOTS entries:

    DT.217246  DT.91745497  DT.91699533  DT.40250563  DT.95306813  DT.95076348  DT.95304362  DT.40192305 
    DT.95351792 

    24/216 AceView cDNA sequences (see all 216):

    AI400478 AA318705 R37704 CD107859 Z43797 AI432147 BM837102 AW770467 
    AA234430 F03103 AI521142 AA234343 CR605949 BG575679 CN479501 Z39864 
    AI674128 CA449375 AI225122 BM022005 BM719316 BM354227 AI521685 NM_006323 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SEC24B (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SEC24B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC24B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACTATAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SEC24B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC24B

    SOURCE GeneReport for Unigene cluster: Hs.292472

    UniProtKB/Swiss-Prot: SC24B_HUMAN, O95487
    Tissue specificity: Expressed in fibroblasts, hepatocytes, and lymphocytes

        SABiosciences Custom PCR Arrays for SEC24B
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC24B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SEC24B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC24B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC24B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC24B gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SEC24B1 SEC24 family, member B (S. cerevisiae) 76.44(n)
    78.79(a)
      422523  NM_001031135.1  NP_001026306.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC24B6
    --
    69(a)
    1 ↔ 1
    5(144556379-144591995)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA987060.12   -- 77.68(n)    CA987060.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF996861.12   -- 74.31(n)    CF996861.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec241 CG1472-PA 48.68(n)
    44.87(a)
      36025  NM_136687.4  NP_610531.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sec-24.23 Yeast YIK9 like 42(a)   IV(12356456-12360940)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC241 Sec24p 44.96(n)
    35.66(a)
      854697   NP_012157.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SEC24A6
    sec24-like transport protein
    31(a)
    1 → many
    3(2245164-2250699)
    rice
    (Oryza sativa)
    Liliopsida --
    protein transport protein Sec24-like, putative, ex...
    31(a)
    1 → many
    4(1853511-1860834)


    ENSEMBL Gene Tree for SEC24B (if available)
    TreeFam Gene Tree for SEC24B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC24B gene
    SEC24A2  SEC24C2  SEC24D2  
    3 SIMAP similar genes for SEC24B using alignment to 2 protein entries:     SC24B_HUMAN (see all proteins):
    SEC24A    SEC24D    SEC24C

    SEC24B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SEC24B
         1 CNV: 68784
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC24B
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC24B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEC24B for disorders           About GeneDecksing

    OMIM gene information: 607184    OMIM disorders: --

    7 diseases for SEC24B:    About MalaCards
    situs inversus    congenital dyserythropoietic anemia    dyserythropoietic anemia    alcohol dependence
    alcoholism    anemia    malaria

    1 disease from the University of Copenhagen DISEASES database for SEC24B:
    Congenital dyserythropoietic anemia
    Human Genome Epidemiology (HuGE) Navigator: SEC24B (1 document)

    Export disorders for SEC24B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC24B gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with SEC24B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sec24 proteins and sorting at the endoplasmic reticulum. (PubMed id 10075675)1, 2, 3, 9 Pagano A....Paccaud J.P. (1999)
    2. The sterol-sensing endoplasmic reticulum (ER) membran e protein TRC8 hampers ER to Golgi transport of sterol regulatory element-bindi ng protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cle avage. (PubMed id 19706601)1, 2 Irisawa M....Sato R. (2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. A family of mammalian proteins homologous to yeast Sec24p. (PubMed id 10329445)1, 3 Tang B.L....Hong W. (1999)
    5. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. (PubMed id 20427317)2, 9 Bonnon C....Hauri H.P. (2010)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
    10. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10427 HGNC: 10704 AceView: SEC24B Ensembl:ENSG00000138802 euGenes: HUgn10427
    ECgene: SEC24B Kegg: 10427 H-InvDB: SEC24B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC24B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC24B gene:
    Search GeneIP for patents involving SEC24B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SEC24B  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC24B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC24B  
     OriGene Protein Over-expression Lysate for SEC24B   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SEC24B   OriGene 3'-UTR Clone for SEC24B  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC24B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SEC24B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEC24B   OriGene Custom Protein Services for SEC24B  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC24B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC24B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC24B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC24B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC24B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC24B
     GenScript Custom Purified and Recombinant Proteins Services for SEC24B GenScript cDNA clones with any tag delivered in your preferred vector for SEC24B
     GenScript Custom Assay Services for SEC24B GenScript Custom Superior Antibodies Services for SEC24B
     GenScript Custom overexpressing Cell Line Services for SEC24B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SEC24B 

     Regulatory tfbs in SEC24B promoter
     Search Chromatin IP Primers for SEC24B
     RT2 qPCR Primer Assay in human, mouse / rat SEC24B
     Search GNC Networks for SEC24B
     SABiosciences PCR Arrays including human, mouse, rat SEC24B
     Search Tocris compounds for SEC24B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SEC24B antibodies
     SEC24B lysates
     Search for Antibodies for SEC24B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SEC24B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SEC24B Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SEC24B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24B
     SwitchGear 3'UTR luciferase reporter plasmids for SEC24B
     SwitchGear Promoter luciferase reporter plasmids for SEC24B
     Search ThermoFisher Antibodies for SEC24B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24B
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEC24B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4