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Aliases for SEC24A Gene

Aliases for SEC24A Gene

  • SEC24 Homolog A, COPII Coat Complex Component 2 3
  • SEC24 (S. Cerevisiae) Related Gene Family, Member A 2
  • SEC24 Family, Member A (S. Cerevisiae) 2
  • SEC24-Related Protein A 4
  • SEC24 Family Member A 2

External Ids for SEC24A Gene

Previous GeneCards Identifiers for SEC24A Gene

  • GC05P133635
  • GC05P134498
  • GC05P134015
  • GC05P134055
  • GC05P134011
  • GC05P129170

Summaries for SEC24A Gene

Entrez Gene Summary for SEC24A Gene

  • The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SEC24A Gene

SEC24A (SEC24 Homolog A, COPII Coat Complex Component) is a Protein Coding gene. Among its related pathways are Immune System and Transport to the Golgi and subsequent modification. An important paralog of this gene is SEC24D.

UniProtKB/Swiss-Prot for SEC24A Gene

  • Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC24A Gene

Genomics for SEC24A Gene

Regulatory Elements for SEC24A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC24A Gene

Chromosome:
5
Start:
134,648,785 bp from pter
End:
134,727,911 bp from pter
Size:
79,127 bases
Orientation:
Plus strand

Genomic View for SEC24A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC24A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC24A Gene

Proteins for SEC24A Gene

  • Protein details for SEC24A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95486-SC24A_HUMAN
    Recommended name:
    Protein transport protein Sec24A
    Protein Accession:
    O95486
    Secondary Accessions:
    • A8MVW3
    • Q8WUV2
    • Q96GP7

    Protein attributes for SEC24A Gene

    Size:
    1093 amino acids
    Molecular mass:
    119749 Da
    Quaternary structure:
    • COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2.
    SequenceCaution:
    • Sequence=CAA10334.1; Type=Frameshift; Positions=68; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC24A Gene

    Alternative splice isoforms for SEC24A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC24A Gene

Proteomics data for SEC24A Gene at MOPED

Post-translational modifications for SEC24A Gene

  • Ubiquitination at Lys 650
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC24A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SEC24A (SEC24A)

No data available for DME Specific Peptides for SEC24A Gene

Domains & Families for SEC24A Gene

Suggested Antigen Peptide Sequences for SEC24A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95486

UniProtKB/Swiss-Prot:

SC24A_HUMAN :
  • Belongs to the SEC23/SEC24 family. SEC24 subfamily.
Family:
  • Belongs to the SEC23/SEC24 family. SEC24 subfamily.
genes like me logo Genes that share domains with SEC24A: view

No data available for Gene Families for SEC24A Gene

Function for SEC24A Gene

Molecular function for SEC24A Gene

GENATLAS Biochemistry:
SEC24 (S. cerevisiae) related gene family, member A
UniProtKB/Swiss-Prot Function:
Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Ontology (GO) - Molecular Function for SEC24A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SEC24A: view

Phenotypes for SEC24A Gene

genes like me logo Genes that share phenotypes with SEC24A: view

Animal Model Products

miRNA for SEC24A Gene

miRTarBase miRNAs that target SEC24A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC24A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC24A Gene

Localization for SEC24A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC24A Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane. Golgi apparatus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC24A Gene COMPARTMENTS Subcellular localization image for SEC24A gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for SEC24A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0030127 COPII vesicle coat IEA --
genes like me logo Genes that share ontologies with SEC24A: view

Pathways & Interactions for SEC24A Gene

genes like me logo Genes that share pathways with SEC24A: view

Pathways by source for SEC24A Gene

1 Qiagen pathway for SEC24A Gene
1 Cell Signaling Technology pathway for SEC24A Gene
1 BioSystems pathway for SEC24A Gene

Gene Ontology (GO) - Biological Process for SEC24A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with SEC24A: view

No data available for SIGNOR curated interactions for SEC24A Gene

Drugs & Compounds for SEC24A Gene

No Compound Related Data Available

Transcripts for SEC24A Gene

Unigene Clusters for SEC24A Gene

SEC24 family, member A (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC24A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC24A Gene

No ASD Table

Relevant External Links for SEC24A Gene

GeneLoc Exon Structure for
SEC24A
ECgene alternative splicing isoforms for
SEC24A

Expression for SEC24A Gene

mRNA expression in normal human tissues for SEC24A Gene

Protein differential expression in normal tissues from HIPED for SEC24A Gene

This gene is overexpressed in Salivary gland (20.0) and Islet of Langerhans (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC24A Gene



SOURCE GeneReport for Unigene cluster for SEC24A Gene Hs.595540

mRNA Expression by UniProt/SwissProt for SEC24A Gene

O95486-SC24A_HUMAN
Tissue specificity: Expressed in fibroblasts, hepatocytes, and lymphocytes
genes like me logo Genes that share expression patterns with SEC24A: view

Protein tissue co-expression partners for SEC24A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SEC24A Gene

Orthologs for SEC24A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC24A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC24A 35
  • 91.54 (n)
  • 91.64 (a)
SEC24A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC24A 35
  • 92.97 (n)
  • 92.94 (a)
SEC24A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec24a 35
  • 88.1 (n)
  • 88.81 (a)
Sec24a 16
Sec24a 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC24A 35
  • 99.63 (n)
  • 99.45 (a)
SEC24A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec24a 35
  • 87.79 (n)
  • 88.8 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC24A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC24A 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC24A 35
  • 75.05 (n)
  • 77.27 (a)
SEC24A 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC24A 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec24a 35
  • 70.64 (n)
  • 74.15 (a)
Str.6479 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7689 35
zebrafish
(Danio rerio)
Actinopterygii LOC100000526 35
  • 65.63 (n)
  • 74.94 (a)
sec24a 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005263 35
  • 54.46 (n)
  • 54.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec24 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-24.2 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC24 36
  • 30 (a)
ManyToMany
SFB2 36
  • 31 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ERMO2 35
  • 49.12 (n)
  • 41.06 (a)
rice
(Oryza sativa)
Liliopsida Os.8704 35
Os04g0129500 35
  • 50.45 (n)
  • 43.67 (a)
corn
(Zea mays)
Liliopsida Zm.6026 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9300 36
  • 56 (a)
OneToMany
Species with no ortholog for SEC24A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC24A Gene

ENSEMBL:
Gene Tree for SEC24A (if available)
TreeFam:
Gene Tree for SEC24A (if available)

Paralogs for SEC24A Gene

Paralogs for SEC24A Gene

(3) SIMAP similar genes for SEC24A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SEC24A Gene

genes like me logo Genes that share paralogs with SEC24A: view

Variants for SEC24A Gene

Sequence variations from dbSNP and Humsavar for SEC24A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_037253 -
VAR_037254 -
VAR_037255 -

Structural Variations from Database of Genomic Variants (DGV) for SEC24A Gene

Variant ID Type Subtype PubMed ID
nsv830491 CNV Loss 17160897
nsv5012 CNV Loss 18451855
nsv830493 CNV Loss 17160897
nsv509088 CNV Insertion 20534489

Variation tolerance for SEC24A Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC24A Gene

HapMap Linkage Disequilibrium report
SEC24A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC24A Gene

Disorders for SEC24A Gene

Relevant External Links for SEC24A

Genetic Association Database (GAD)
SEC24A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC24A
genes like me logo Genes that share disorders with SEC24A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC24A Gene

Publications for SEC24A Gene

  1. Sec24 proteins and sorting at the endoplasmic reticulum. (PMID: 10075675) Pagano A. … Paccaud J.-P. (J. Biol. Chem. 1999) 2 67
  2. A family of mammalian proteins homologous to yeast Sec24p. (PMID: 10329445) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1999) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for SEC24A Gene

Sources for SEC24A Gene

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