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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC24A Gene

protein-coding   GIFtS: 57
GCID: GC05P134011

SEC24 Family, Member A (S. Cerevisiae)

(Previous names: SEC24 (S. cerevisiae) related gene family, member A)
  Search for SEC24A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SEC24 Family, Member A (S. Cerevisiae)1 2
SEC24-Related Protein A2 3
SEC24 (S. Cerevisiae) Related Gene Family, Member A1
Protein Transport Protein Sec24A2
SEC24 Related Gene Family, Member A2

External Ids:    HGNC: 107031   Entrez Gene: 108022   Ensembl: ENSG000001136157   OMIM: 6071835   UniProtKB: O954863   

Export aliases for SEC24A gene to outside databases

Previous GC identifers: GC05P133635 GC05P134498 GC05P134015 GC05P134055 GC05P129170


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC24A Gene:
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein
is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic
reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar
proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for SEC24A Gene: 
SEC24A (SEC24 family, member A (S. cerevisiae)) is a protein-coding gene. Among its related super-pathways are COPII (Coat Protein 2) Mediated Vesicle Transport and Clathrin-dependent protein traffic. GO annotations related to this gene include molecular_function and zinc ion binding. An important paralog of this gene is SEC24C.

UniProtKB/Swiss-Prot: SC24A_HUMAN, O95486
Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma
membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC24A gene promoter:
         TBP   RFX1   USF1   Bach2   FOXL1   AREB6   CREB   USF-1   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SEC24A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC24A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

SEC24A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC24A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P134011:  view genomic region     (about GC identifiers)

Start:
133,984,479 bp from pter      End:
134,063,601 bp from pter
Size:
79,123 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SC24A_HUMAN, O95486 (See protein sequence)
Recommended Name: Protein transport protein Sec24A  
Size: 1093 amino acids; 119749 Da
Subunit: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A
is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2
Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Endoplasmic
reticulum membrane (By similarity). Golgi apparatus membrane (By similarity)
Sequence caution: Sequence=CAA10334.1; Type=Frameshift; Positions=68;
4 PDB 3D structures from and Proteopedia for SEC24A:
2NUP (3D)        2NUT (3D)        3EGD (3D)        3EGX (3D)    
Secondary accessions: A8MVW3 Q8WUV2 Q96GP7
Alternative splicing: 2 isoforms:  O95486-1   O95486-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC24A: NX_O95486

Explore proteomics data for SEC24A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95486

  • SEC24A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEC24A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001239160.1  NP_068817.1  

    ENSEMBL proteins: 
     ENSP00000381823   ENSP00000321749   ENSP00000424273  
    Reactome Protein details: O95486
    Human Recombinant Protein Products for SEC24A: 
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    Novus Biologicals SEC24A Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC24A 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005829cytosol TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0030127COPII vesicle coat NAS--

    SEC24A for ontologies           About GeneDecksing



    SEC24A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR006900 Sec23/24_helical_dom
     IPR012990 Sec23_24_beta_S
     IPR006896 Sec23/24_trunk_dom
     IPR006895 Znf_Sec23_Sec24
     IPR007123 Gelsolin_dom

    Graphical View of Domain Structure for InterPro Entry O95486

    ProtoNet protein and cluster: O95486

    4 Blocks protein domains:
    IPB006895 Sec23/Sec24 zinc finger
    IPB006896 Sec23/Sec24 trunk domain
    IPB006900 Sec23/Sec24 helical domain
    IPB007123 Gelsolin region


    UniProtKB/Swiss-Prot: SC24A_HUMAN, O95486
    Similarity: Belongs to the SEC23/SEC24 family. SEC24 subfamily


    SEC24A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC24A_HUMAN, O95486
    Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
    reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma
    membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

         Genatlas biochemistry entry for SEC24A:
    SEC24 (S. cerevisiae) related gene family, member A

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008270zinc ion binding IEA--
         
    SEC24A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEC24A:
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sec24a):
     homeostasis/metabolism 

    SEC24A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEC24A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEC24A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC24A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC24A 

    miRNA
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    miRTarBase miRNAs that target SEC24A:
    hsa-mir-16 (MIRT001420)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC24A
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24A (see all 29):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-16-2* hsa-miR-429 hsa-miR-128 hsa-miR-944 hsa-miR-30d hsa-miR-1244
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: SEC24A (NM_021982)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEC24A About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1COPII (Coat Protein 2) Mediated Vesicle Transport
    COPII (Coat Protein 2) Mediated Vesicle Transport0.36
    ER to Golgi Transport0.36
    Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC0.31
    Normal wtCFTR traffic / ER-to-Golgi 0.36
    2Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.67
    SREBP signalling0.37
    4Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SEC24A
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC24A
        SREBP Proteolysis

    1 Cell Signaling Technology (CST) Pathway for SEC24A
        Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for SEC24A
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SEC24A
        SREBP signalling

    5/18        Reactome Pathways for SEC24A (see all 18)
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Membrane Trafficking
    Metabolism
    COPII (Coat Protein 2) Mediated Vesicle Transport
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)


    1         Kegg Pathway  (Kegg details for SEC24A):
        Protein processing in endoplasmic reticulum


    SEC24A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC24A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/83 Interacting proteins for SEC24A (O954862, 3 ENSP000003818234) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156452, 3, ENSP000001663454MINT-67638 I2D: score=5 STRING: ENSP00000166345
    MLST8Q9BVC43, ENSP000003718884I2D: score=1 STRING: ENSP00000371888
    DDA1Q9BW613I2D: score=1 
    FYCO1Q9BQS83I2D: score=1 
    GABARAPO951663I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    SEC24A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC24A (SC24A)

    Search CenterWatch for drugs/clinical trials and news about SEC24A / SC24A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC24A gene (2 alternative transcripts): 
    NM_001252231.1  NM_021982.2  

    Unigene Cluster for SEC24A:

    SEC24 family, member A (S. cerevisiae)
    Hs.595540  [show with all ESTs]
    Unigene Representative Sequence: NM_021982
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398844(uc003kzs.3 uc011cxu.2) ENST00000322887(uc021ydr.1)
    ENST00000513123
    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC24A (see all 29):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-16-2* hsa-miR-429 hsa-miR-128 hsa-miR-944 hsa-miR-30d hsa-miR-1244
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC24A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24A
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    Additional mRNA sequence: 

    AJ131244.1 AK026545.1 AK123149.1 AK304060.1 AL080064.1 AL080165.1 AL137677.1 BC009325.2 
    BC019341.1 

    11 DOTS entries:

    DT.311607  DT.91753010  DT.100798517  DT.100730897  DT.91701935  DT.40264068  DT.97841988  DT.311609 
    DT.439549  DT.86852916  DT.91753007 

    24/149 AceView cDNA sequences (see all 149):

    CD644395 BG058644 BU624058 AA233470 AL043181 CA421918 CB994055 AA278351 
    CD655025 CB136949 Z40364 AI754055 CB157979 BU508559 AA309113 AA329146 
    CD677660 BM795190 AA252104 BQ214308 AI421248 CD109783 BQ188389 BC009325 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC24A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGACCATTG
    SEC24A Expression
    About this image


    See SEC24A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC24A

    SOURCE GeneReport for Unigene cluster: Hs.595540

    UniProtKB/Swiss-Prot: SC24A_HUMAN, O95486
    Tissue specificity: Expressed in fibroblasts, hepatocytes, and lymphocytes

        SABiosciences Custom PCR Arrays for SEC24A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC24A gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec24a1 , 5 Sec24 related gene family, member A (S. cerevisiae)1, 5 87.98(n)1
    88.72(a)1
      11 (31.28 cM)5
    773711  NM_175255.31  NP_780464.21 
     516922645 
    chicken
    (Gallus gallus)
    Aves SEC24A1 SEC24 family, member A (S. cerevisiae) 75.39(n)
    77.72(a)
      416313  XM_414630.3  XP_414630.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEC24A6
    SEC24 family, member A (S. cerevisiae)
    75(a)
    1 ↔ 1
    GL343223.1(177015-217799)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76892 Xenopus laevis transcribed sequence with moderate similarity more 77.89(n)    BJ057794.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000005261 protein transport protein Sec24A-like 59.91(n)
    64.96(a)
      100000526  XM_001340672.3  XP_001340708.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec246
    sec24
    38(a)
    1 → many
    2R(5763737-5769858)
    worm
    (Caenorhabditis elegans)
    Secernentea sec-24.21 Protein SEC-24.2 49.48(n)
    42.38(a)
      178183  NM_069953.6  NP_502354.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SFB21 Sfb2p 46.44(n)
    35.72(a)
      855678   NP_014349.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ERMO21 sec24-like transport protein 47.11(n)
    38.91(a)
      819896  NM_111590.3  NP_187366.2 
    rice
    (Oryza sativa)
    Liliopsida Os.87042 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.01(n)    AK120404.1 


    ENSEMBL Gene Tree for SEC24A (if available)
    TreeFam Gene Tree for SEC24A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC24A gene
    SEC24C2  SEC24D2  SEC24B2  
    3 SIMAP similar genes for SEC24A using alignment to 2 protein entries:     SC24A_HUMAN (see all proteins):
    SEC24B    SEC24D    SEC24C

    SEC24A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SEC24A
    PGOHUM00000237170


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1484 SNPs in SEC24A are shown (see all 1484)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818615511,2
    --133982634(+) GTTTTA/GAACTC 2 -- us2k10--------
    rs1400756441,2
    --133982710(+) CGCCCA/GAGCAA 2 -- us2k10--------
    rs1854520841,2
    --133982784(+) TAGTTA/GTTTGA 2 -- us2k10--------
    rs1882523301,2
    --133982850(+) AGAGAA/CAAGAT 2 -- us2k10--------
    rs1814362441,2
    --133982873(+) TGCAGA/GCTGGA 2 -- us2k10--------
    rs1863245921,2
    --133983324(+) TATATA/TTATTT 2 -- us2k10--------
    rs606328421,2
    C,F--133983326(+) TATATA/TTTTTT 2 -- us2k13Minor allele frequency- T:0.17WA NA EA 358
    rs2008211711,2
    --133983327(+) ATATA-/TTTTTT 2 -- us2k10--------
    rs1131544501,2
    F--133983328(+) TATATT/ATTTTA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1437389141,2
    C--133983599(+) GTACAA/GATCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEC24A (133984479 - 134063601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEC24A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509088CNV Insertion20534489
    nsv830491CNV Loss17160897
    nsv5012CNV Loss18451855
    nsv830493CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEC24A for disorders           About MalaCards
    OMIM gene information: 607183    OMIM disorders: --


    SEC24A for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEC24A

    Export disorders for SEC24A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC24A gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SEC24A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sec24 proteins and sorting at the endoplasmic reticulum. (PubMed id 10075675)1, 2, 3 Pagano A....Paccaud J.P. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A family of mammalian proteins homologous to yeast Sec24p. (PubMed id 10329445)1, 3 Tang B.L....Hong W. (1999)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. A Brucella abortus cstA mutant is defective for associ ation with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells. (PubMed id 22820839)1 de Barsy M....De Bolle X. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10802 HGNC: 10703 AceView: SEC24A Ensembl:ENSG00000113615 euGenes: HUgn10802
    ECgene: SEC24A Kegg: 10802 H-InvDB: SEC24A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC24A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/COPII

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC24A gene:
    Search GeneIP for patents involving SEC24A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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