Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEC24A Gene

protein-coding   GIFtS: 57
GCID: GC05P134011

SEC24 Family Member A

(Previous names: SEC24 (S. cerevisiae) related gene family, member A, SEC24...)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SEC24 Family Member A1 2     Protein Transport Protein Sec24A2
SEC24-Related Protein A2 3     SEC24 Family, Member A2
SEC24 (S. Cerevisiae) Related Gene Family, Member A1     SEC24 Related Gene Family, Member A2
SEC24 Family, Member A (S. Cerevisiae)1     

External Ids:    HGNC: 107031   Entrez Gene: 108022   Ensembl: ENSG000001136157   OMIM: 6071835   UniProtKB: O954863   

Export aliases for SEC24A gene to outside databases

Previous GC identifers: GC05P133635 GC05P134498 GC05P134015 GC05P134055 GC05P129170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEC24A Gene:
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein
is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic
reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar
proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for SEC24A Gene:
SEC24A (SEC24 family member A) is a protein-coding gene. An important paralog of this gene is SEC24C.

UniProtKB/Swiss-Prot: SC24A_HUMAN, O95486
Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma
membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC24A gene promoter:
         TBP   RFX1   USF1   Bach2   FOXL1   AREB6   CREB   USF-1   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEC24A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC24A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

SEC24A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC24A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P134011:  view genomic region     (about GC identifiers)

Start:
133,984,479 bp from pter      End:
134,063,601 bp from pter
Size:
79,123 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SC24A_HUMAN, O95486 (See protein sequence)
Recommended Name: Protein transport protein Sec24A  
Size: 1093 amino acids; 119749 Da
Subunit: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A
is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2
Sequence caution: Sequence=CAA10334.1; Type=Frameshift; Positions=68;
4 PDB 3D structures from and Proteopedia for SEC24A:
2NUP (3D)        2NUT (3D)        3EGD (3D)        3EGX (3D)    
Secondary accessions: A8MVW3 Q8WUV2 Q96GP7
Alternative splicing: 2 isoforms:  O95486-1   O95486-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC24A: NX_O95486

Explore proteomics data for SEC24A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys451, Lys650
  • Modification sites at PhosphoSitePlus

  • See SEC24A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239160.1  NP_068817.1  

    ENSEMBL proteins: 
     ENSP00000381823   ENSP00000321749   ENSP00000424273  
    Reactome Protein details: O95486

    SEC24A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEC24A
    GenScript Custom Purified and Recombinant Proteins Services for SEC24A
    Novus Biologicals SEC24A Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC24A

     
    Search eBioscience for Proteins for SEC24A 

    SEC24A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SEC24A 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEC24A
    Novus Biologicals SEC24A Antibodies
    Abcam antibodies for SEC24A
    Cloud-Clone Corp. Antibodies for SEC24A
    ThermoFisher Antibodies for SEC24A
    LSBio Antibodies in human, mouse, rat for SEC24A

    SEC24A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEC24A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEC24A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEC24A
    Cloud-Clone Corp. CLIAs for SEC24A
    Search eBioscience for ELISAs for SEC24A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR006900 Sec23/24_helical_dom
     IPR012990 Sec23_24_beta_S
     IPR006896 Sec23/24_trunk_dom
     IPR006895 Znf_Sec23_Sec24
     IPR007123 Gelsolin_dom

    Graphical View of Domain Structure for InterPro Entry O95486

    ProtoNet protein and cluster: O95486

    4 Blocks protein domains:
    IPB006895 Sec23/Sec24 zinc finger
    IPB006896 Sec23/Sec24 trunk domain
    IPB006900 Sec23/Sec24 helical domain
    IPB007123 Gelsolin region


    UniProtKB/Swiss-Prot: SC24A_HUMAN, O95486
    Similarity: Belongs to the SEC23/SEC24 family. SEC24 subfamily


    Find genes that share domains with SEC24A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC24A_HUMAN, O95486
    Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic
    reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma
    membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

         Genatlas biochemistry entry for SEC24A:
    SEC24 (S. cerevisiae) related gene family, member A

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with SEC24A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SEC24A:
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sec24a):
     homeostasis/metabolism 

    Find genes that share phenotypes with SEC24A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC24A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC24A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC24A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC24A

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC24A:
    hsa-mir-320a (MIRT044746), hsa-mir-92a-3p (MIRT049703), hsa-mir-125b-5p (MIRT046042), hsa-mir-30a-5p (MIRT028545), hsa-mir-16-5p (MIRT001420)

    Block miRNA regulation of human, mouse, rat SEC24A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEC24A (see all 29):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-16-2* hsa-miR-429 hsa-miR-128 hsa-miR-944 hsa-miR-30d hsa-miR-1244
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEC24A
    Predesigned siRNA for gene silencing in human, mouse, rat SEC24A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC24A

    Clone
    Products:
         
    OriGene clones in human, mouse for SEC24A (see all 6)
    OriGene ORF clones in mouse, rat for SEC24A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC24A (NM_021982)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC24A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEC24A
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEC24A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SC24A_HUMAN, O95486: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Endoplasmic
    reticulum membrane (By similarity). Golgi apparatus membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum4
    golgi apparatus2
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005829cytosol TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0030127COPII vesicle coat IEA--

    Find genes that share ontologies with SEC24A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SEC24A About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1ER to Golgi Transport
    ER to Golgi Transport0.36
    Antigen Presentation- Folding, assembly and peptide loading of class I MHC0.32
    Delta508 CFTR traffic ER to Golgi in CF0.36
    COPII (Coat Protein 2) Mediated Vesicle Transport0.00
    Normal wtCFTR traffic ER to Golgi 0.36
    2Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    SREBP signalling0.31
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Transport to the Golgi and subsequent modification0.40
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41


    Find genes that share SuperPaths with SEC24A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SEC24A
        SREBP Proteolysis

    1 Cell Signaling Technology (CST) Pathway for SEC24A
        Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for SEC24A
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SEC24A
        SREBP signalling

    4 Reactome Pathways for SEC24A
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    COPII (Coat Protein 2) Mediated Vesicle Transport
    Regulation of cholesterol biosynthesis by SREBP (SREBF)
    MHC class II antigen presentation


    1 Kegg Pathway  (Kegg details for SEC24A):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC24A
    Interactions:

        Search GeneGlobe Interaction Network for SEC24A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC24A (O954862, 3 ENSP000003818234) via UniProtKB, MINT, STRING, and/or I2D (see all 131)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156452, 3, ENSP000001663454MINT-67638 I2D: score=5 STRING: ENSP00000166345
    MLST8Q9BVC43, ENSP000003718884I2D: score=1 STRING: ENSP00000371888
    DDA1Q9BW613I2D: score=1 
    FYCO1Q9BQS83I2D: score=1 
    GABARAPO951663I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with SEC24A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC24A (SC24A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEC24A gene (2 alternative transcripts): 
    NM_001252231.1  NM_021982.2  

    Unigene Cluster for SEC24A:

    SEC24 family, member A (S. cerevisiae)
    Hs.595540  [show with all ESTs]
    Unigene Representative Sequence: NM_021982
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398844(uc003kzs.3 uc011cxu.2) ENST00000322887(uc021ydr.1)
    ENST00000513123
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEC24A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEC24A (see all 29):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-16-2* hsa-miR-429 hsa-miR-128 hsa-miR-944 hsa-miR-30d hsa-miR-1244
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEC24A
    Predesigned siRNA for gene silencing in human, mouse, rat SEC24A
    Clone
    Products:
         
    OriGene clones in human, mouse for SEC24A (see all 6)
    OriGene ORF clones in mouse, rat for SEC24A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC24A (NM_021982)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC24A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC24A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC24A
      QuantiTect SYBR Green Assays in human, mouse, rat SEC24A
      QuantiFast Probe-based Assays in human, mouse, rat SEC24A

    Additional mRNA sequence: 

    AJ131244.1 AK026545.1 AK123149.1 AK304060.1 AL080064.1 AL080165.1 AL137677.1 BC009325.2 
    BC019341.1 

    11 DOTS entries:

    DT.311607  DT.91753010  DT.100798517  DT.100730897  DT.91701935  DT.40264068  DT.97841988  DT.311609 
    DT.439549  DT.86852916  DT.91753007 

    Selected AceView cDNA sequences (see all 149):

    BU624058 BX470927 BQ773544 CD677660 CB157979 AI754055 AK026545 CA421918 
    BU627141 BC019341 BG058644 BX481102 AA278351 AA233470 AA252104 CB992156 
    BQ188389 CN480649 AK123149 BM795190 CB136949 AI421248 AL043181 BQ214308 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEC24A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGACCATTG
    SEC24A Expression
    About this image

    SEC24A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC24A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.595540

    UniProtKB/Swiss-Prot: SC24A_HUMAN, O95486
    Tissue specificity: Expressed in fibroblasts, hepatocytes, and lymphocytes

        Custom PCR Arrays for SEC24A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC24A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC24A
    QuantiTect SYBR Green Assays in human, mouse, rat SEC24A
    QuantiFast Probe-based Assays in human, mouse, rat SEC24A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC24A gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec24a1 , 5 Sec24 related gene family, member A (S. cerevisiae)1, 5 88.1(n)1
    88.81(a)1
      11 (31.28 cM)5
    773711  NM_175255.31  NP_780464.21 
     516922645 
    chicken
    (Gallus gallus)
    Aves SEC24A1 SEC24 family, member A (S. cerevisiae) 75.05(n)
    77.27(a)
      416313  XM_414630.4  XP_414630.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEC24A6
    SEC24 family member A
    75(a)
    1 ↔ 1
    GL343223.1(177015-217799)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76892 Xenopus laevis transcribed sequence with moderate similarity more 77.89(n)    BJ057794.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000005261 protein transport protein Sec24A-like 65.63(n)
    74.94(a)
      100000526  XM_001340672.4  XP_001340708.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec246
    sec24
    40(a)
    1 → many
    2R(5763737-5769858)
    worm
    (Caenorhabditis elegans)
    Secernentea sec-24.26
    Protein SEC-24.2 (sec-24.2) mRNA, complete cds
    38(a)
    1 → many
    IV(12355711-12360792) WBGene00004756
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SFB26
    SEC246
    Component of the Sec23p-Sfb2p heterodimer of the C...
    Component of the Sec23p-Sec24p heterodimer of the ...
    31(a)
    30(a)
    many ↔ many
    many ↔ many
    XIV(535281-537911) YNL049C
    IX(157385-160165) YIL109C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ERMO21 ERMO2 49.12(n)
    41.06(a)
      819896  NM_111590.3  NP_187366.2 
    rice
    (Oryza sativa)
    Liliopsida Os.87042 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.01(n)    AK120404.1 


    ENSEMBL Gene Tree for SEC24A (if available)
    TreeFam Gene Tree for SEC24A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEC24A gene
    SEC24C2  SEC24D2  SEC24B2  
    3 SIMAP similar genes for SEC24A using alignment to 2 protein entries:     SC24A_HUMAN (see all proteins):
    SEC24B    SEC24D    SEC24C

    Find genes that share paralogs with SEC24A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SEC24A
    PGOHUM00000237170


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEC24A (see all 1484)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818615511,2
    --133982634(+) GTTTTA/GAACTC 2 -- us2k10--------
    rs1400756441,2
    --133982710(+) CGCCCA/GAGCAA 2 -- us2k10--------
    rs1854520841,2
    --133982784(+) TAGTTA/GTTTGA 2 -- us2k10--------
    rs1882523301,2
    --133982850(+) AGAGAA/CAAGAT 2 -- us2k10--------
    rs1814362441,2
    --133982873(+) TGCAGA/GCTGGA 2 -- us2k10--------
    rs1863245921,2
    --133983324(+) TATATA/TTATTT 2 -- us2k10--------
    rs606328421,2
    C,F--133983326(+) TATATA/TTTTTT 2 -- us2k13Minor allele frequency- T:0.17WA NA EA 358
    rs2008211711,2
    --133983327(+) ATATA-/TTTTTT 2 -- us2k10--------
    rs1131544501,2
    F--133983328(+) TATATT/ATTTTA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1437389141,2
    C--133983599(+) GTACAA/GATCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEC24A (133984479 - 134063601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEC24A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509088CNV Insertion20534489
    nsv830491CNV Loss17160897
    nsv5012CNV Loss18451855
    nsv830493CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC24A
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC24A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607183    OMIM disorders: --


    Find genes that share disorders with SEC24A           About GenesLikeMe

    Genetic Association Database (GAD): SEC24A

    Export disorders for SEC24A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEC24A gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SEC24A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sec24 proteins and sorting at the endoplasmic reticulum. (PubMed id 10075675)1, 2, 3 Pagano A.... Paccaud J.-P. (J. Biol. Chem. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A family of mammalian proteins homologous to yeast Sec24p. (PubMed id 10329445)1, 3 Tang B.L.... Hong W. (Biochem. Biophys. Res. Commun. 1999)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells. (PubMed id 22820839)1 de Barsy M....De Bolle X. (Microbiology (Reading, Engl.) 2012)
    6. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10802 HGNC: 10703 AceView: SEC24A Ensembl:ENSG00000113615 euGenes: HUgn10802
    ECgene: SEC24A Kegg: 10802 H-InvDB: SEC24A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEC24A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/COPII

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEC24A gene:
    Search GeneIP for patents involving SEC24A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEC24A  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SEC24A  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEC24A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SEC24A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEC24A   OriGene Custom Protein Services for SEC24A  

     
     
     Block miRNA regulation of human, mouse, rat SEC24A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEC24A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC24A Predesigned siRNA for gene silencing in human, mouse, rat SEC24A
     QuantiFast Probe-based Assays in human, mouse, rat SEC24A QuantiTect SYBR Green Assays in human, mouse, rat SEC24A
     Custom PCR Arrays for SEC24A Search Chromatin IP Primers for SEC24A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC24A  Search GeneGlobe Interaction Network for SEC24A
     Regulatory tfbs in SEC24A promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEC24A GenScript cDNA clones with any tag delivered in your preferred vector for SEC24A
     GenScript Custom Assay Services for SEC24A GenScript Custom overexpressing Cell Line Services for SEC24A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for SEC24A 

     Search Tocris compounds for SEC24A (SC24A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEC24A antibodies
     SEC24A proteins
     Antibodies for SEC24A
     See all of Abcam's Antibodies, Kits and Proteins for SEC24A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SEC24A
     Antibodies for SEC24A
     ELISAs for SEC24A
     CLIAs for SEC24A



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEC24A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC24A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SEC24A
     Browse SwitchGear Promoter luciferase reporter plasmids for SEC24A
     ThermoFisher Antibodies for SEC24A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC24A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC24A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC24A
     LSBio Antibodies in human, mouse, rat for SEC24A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SEC24A
      Search eBioscience for proteins for SEC24A
      Search eBioscience for elisas for SEC24A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEC24A gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4