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Aliases for SEC24A Gene

Aliases for SEC24A Gene

  • SEC24 Homolog A, COPII Coat Complex Component 2 3 5
  • SEC24 (S. Cerevisiae) Related Gene Family, Member A 2
  • SEC24 Family, Member A (S. Cerevisiae) 2
  • SEC24-Related Protein A 4
  • SEC24 Family Member A 2

External Ids for SEC24A Gene

Previous GeneCards Identifiers for SEC24A Gene

  • GC05P133635
  • GC05P134498
  • GC05P134015
  • GC05P134055
  • GC05P134011
  • GC05P129170

Summaries for SEC24A Gene

Entrez Gene Summary for SEC24A Gene

  • The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SEC24A Gene

SEC24A (SEC24 Homolog A, COPII Coat Complex Component) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Innate Immune System. An important paralog of this gene is SEC24B.

UniProtKB/Swiss-Prot for SEC24A Gene

  • Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC24A Gene

Genomics for SEC24A Gene

Regulatory Elements for SEC24A Gene

Enhancers for SEC24A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G134546 2 FANTOM5 Ensembl ENCODE dbSUPER 11 -96.7 -96726 10.1 HDGF PKNOX1 ARNT SIN3A YBX1 ZBTB7B ZNF766 ZNF143 ZNF207 FOS CAMLG PPP2CA JADE2 SEC24A UBE2B TXNDC15 CDKL3 TCF7 GC05M134520 GC05M134578
GH05G134039 1.5 Ensembl ENCODE dbSUPER 10.7 -609.2 -609154 1.0 ATF1 MLX ARNT ARID4B SIN3A BRCA1 ZNF2 ZNF48 GTF3C2 SLC30A9 C5orf66 SEC24A GC05P134014 ENSG00000271128
GH05G134521 1.4 ENCODE dbSUPER 10.8 -123.3 -123262 7.3 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A FEZF1 DMAP1 C5orf66 RNU6-456P RPS10P11 CDKN2AIPNL SEC24A ENSG00000248559 LINC01843 JADE2 GC05M134520
GH05G134757 1.2 ENCODE 10.8 +110.4 110377 2.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 C5orf66 C5orf24 SEC24A CDKL3 DDX46 RPL34P13
GH05G134903 1.1 ENCODE 10.7 +256.6 256642 3.6 FOXA2 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 C5orf66 SEC24A TXNDC15 C5orf66-AS1 ENSG00000279799 MTCYBP18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC24A on UCSC Golden Path with GeneCards custom track

Promoters for SEC24A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187110 215 2801 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for SEC24A Gene

Chromosome:
5
Start:
134,648,785 bp from pter
End:
134,727,911 bp from pter
Size:
79,127 bases
Orientation:
Plus strand

Genomic View for SEC24A Gene

Genes around SEC24A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC24A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC24A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC24A Gene

Proteins for SEC24A Gene

  • Protein details for SEC24A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95486-SC24A_HUMAN
    Recommended name:
    Protein transport protein Sec24A
    Protein Accession:
    O95486
    Secondary Accessions:
    • A8MVW3
    • Q8WUV2
    • Q96GP7

    Protein attributes for SEC24A Gene

    Size:
    1093 amino acids
    Molecular mass:
    119749 Da
    Quaternary structure:
    • COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2.
    SequenceCaution:
    • Sequence=CAA10334.1; Type=Frameshift; Positions=68; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC24A Gene

    Alternative splice isoforms for SEC24A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC24A Gene

Post-translational modifications for SEC24A Gene

  • Ubiquitination at isoforms=650
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC24A Gene

No data available for DME Specific Peptides for SEC24A Gene

Domains & Families for SEC24A Gene

Suggested Antigen Peptide Sequences for SEC24A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95486

UniProtKB/Swiss-Prot:

SC24A_HUMAN :
  • Belongs to the SEC23/SEC24 family. SEC24 subfamily.
Family:
  • Belongs to the SEC23/SEC24 family. SEC24 subfamily.
genes like me logo Genes that share domains with SEC24A: view

No data available for Gene Families for SEC24A Gene

Function for SEC24A Gene

Molecular function for SEC24A Gene

GENATLAS Biochemistry:
SEC24 (S. cerevisiae) related gene family, member A
UniProtKB/Swiss-Prot Function:
Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Gene Ontology (GO) - Molecular Function for SEC24A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SEC24A: view
genes like me logo Genes that share phenotypes with SEC24A: view

Animal Models for SEC24A Gene

MGI Knock Outs for SEC24A:

Animal Model Products

CRISPR Products

miRNA for SEC24A Gene

miRTarBase miRNAs that target SEC24A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEC24A Gene

Localization for SEC24A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC24A Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane. Golgi apparatus membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC24A gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
golgi apparatus 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SEC24A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with SEC24A: view

Pathways & Interactions for SEC24A Gene

genes like me logo Genes that share pathways with SEC24A: view

Gene Ontology (GO) - Biological Process for SEC24A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS,IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SEC24A: view

No data available for SIGNOR curated interactions for SEC24A Gene

Drugs & Compounds for SEC24A Gene

No Compound Related Data Available

Transcripts for SEC24A Gene

Unigene Clusters for SEC24A Gene

SEC24 family, member A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC24A Gene

No ASD Table

Relevant External Links for SEC24A Gene

GeneLoc Exon Structure for
SEC24A
ECgene alternative splicing isoforms for
SEC24A

Expression for SEC24A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC24A Gene

Protein differential expression in normal tissues from HIPED for SEC24A Gene

This gene is overexpressed in Salivary gland (20.0) and Islet of Langerhans (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC24A Gene



Protein tissue co-expression partners for SEC24A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC24A Gene:

SEC24A

SOURCE GeneReport for Unigene cluster for SEC24A Gene:

Hs.595540

mRNA Expression by UniProt/SwissProt for SEC24A Gene:

O95486-SC24A_HUMAN
Tissue specificity: Expressed in fibroblasts, hepatocytes, and lymphocytes.

Evidence on tissue expression from TISSUES for SEC24A Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Eye(4.2)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with SEC24A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC24A Gene

Orthologs for SEC24A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC24A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC24A 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia SEC24A 34 35
  • 92.97 (n)
cow
(Bos Taurus)
Mammalia SEC24A 34 35
  • 91.54 (n)
mouse
(Mus musculus)
Mammalia Sec24a 34 16 35
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia Sec24a 34
  • 87.79 (n)
oppossum
(Monodelphis domestica)
Mammalia SEC24A 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC24A 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC24A 34 35
  • 75.05 (n)
lizard
(Anolis carolinensis)
Reptilia SEC24A 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec24a 34
  • 70.64 (n)
Str.6479 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7689 34
zebrafish
(Danio rerio)
Actinopterygii LOC100000526 34
  • 65.63 (n)
sec24a 35
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005263 34
  • 54.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec24 35
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-24.2 35
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFB2 35
  • 31 (a)
ManyToMany
SEC24 35
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ERMO2 34
  • 49.12 (n)
rice
(Oryza sativa)
Liliopsida Os04g0129500 34
  • 50.45 (n)
Os.8704 34
corn
(Zea mays)
Liliopsida Zm.6026 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9300 35
  • 56 (a)
OneToMany
Species where no ortholog for SEC24A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC24A Gene

ENSEMBL:
Gene Tree for SEC24A (if available)
TreeFam:
Gene Tree for SEC24A (if available)

Paralogs for SEC24A Gene

Paralogs for SEC24A Gene

(3) SIMAP similar genes for SEC24A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SEC24A Gene

genes like me logo Genes that share paralogs with SEC24A: view

Variants for SEC24A Gene

Sequence variations from dbSNP and Humsavar for SEC24A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000005511 -- 134,685,850(+) CGGGC(C/G)TGGTG intron-variant
rs1000066839 -- 134,655,269(+) TGCTG(A/G)TTGGG intron-variant
rs1000104272 -- 134,696,606(+) CCATT(C/G)TCCTG intron-variant
rs1000204922 -- 134,664,701(+) TTACA(C/T)GGCAA intron-variant
rs1000227641 -- 134,704,178(+) GATTC(C/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC24A Gene

Variant ID Type Subtype PubMed ID
esv3566677 CNV deletion 23714750
esv3575882 CNV gain 25503493
esv3606851 CNV loss 21293372
nsv1114731 CNV deletion 24896259
nsv5012 CNV deletion 18451855
nsv509088 CNV insertion 20534489
nsv830491 CNV loss 17160897
nsv830493 CNV loss 17160897

Variation tolerance for SEC24A Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC24A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC24A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC24A Gene

Disorders for SEC24A Gene

Relevant External Links for SEC24A

Genetic Association Database (GAD)
SEC24A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC24A

No disorders were found for SEC24A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC24A Gene

Publications for SEC24A Gene

  1. Sec24 proteins and sorting at the endoplasmic reticulum. (PMID: 10075675) Pagano A. … Paccaud J.-P. (J. Biol. Chem. 1999) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A family of mammalian proteins homologous to yeast Sec24p. (PMID: 10329445) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1999) 2 3 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SEC24A Gene

Sources for SEC24A Gene

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