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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC23IP Gene

protein-coding   GIFtS: 51
GCID: GC10P121642

SEC23 interacting protein

 Explore 4 diseases affiliated with
SEC23IP via our new
 Human Malady Compendium 
Biological research products
for SEC23IP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SEC23 Interacting Protein1 2
P1252
P1252
P125A2
SEC23-Interacting Protein2

External Ids:    HGNC: 170181   Entrez Gene: 111962   Ensembl: ENSG000001076517   UniProtKB: Q9Y6Y83   

Export aliases for SEC23IP gene to outside databases

Previous GC identifers: GC10P120895 GC10P121783 GC10P121316 GC10P115281


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC23IP:
This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is
localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the
multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development,
suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced
transcript variants have been observed for this gene. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: S23IP_HUMAN, Q9Y6Y8
Function: Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to
phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol
5-phosphate (PI(5)P)

Gene Wiki entry for SEC23IP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC23IP gene promoter:
         AhR   USF1   Sox5   Elk-1   USF2   Arnt   AREB6   Hlf   Ik-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC23IP promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC23IP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC23IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25-q26   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.11-q26.12

SEC23IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC23IP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P121642:  view genomic region     (about GC identifiers)

Start:
121,652,223 bp from pter      End:
121,702,014 bp from pter
Size:
49,792 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S23IP_HUMAN, Q9Y6Y8 (See protein sequence)
Recommended Name: SEC23-interacting protein  
Size: 1000 amino acids; 111076 Da
Subunit: Interacts with SEC23A
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic
side. Endoplasmic reticulum (Probable)
Caution: Although belonging to the PA-PL1 family, does not seem to have any phospholipase activity
Sequence caution: Sequence=AAP35401.1; Type=Frameshift; Positions=471;
Secondary accessions: D3DRD2 Q8IXH5 Q9BUK5
Alternative splicing: 2 isoforms:  Q9Y6Y8-1   Q9Y6Y8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC23IP: NX_Q9Y6Y8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6Y8

  • SEC23IP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009121.1  
    ENSEMBL proteins: 
     ENSP00000358071   ENSP00000416723   ENSP00000396906   ENSP00000438773  

    Human Recombinant Protein Products: 
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    Novus Biologicals SEC23IP Protein
    Novus Biologicals SEC23IP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEC23IP

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10400679
    GO:0005783endoplasmic reticulum IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment TAS10400679
    GO:0012507ER to Golgi transport vesicle membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    SEC23IP for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SEC23IP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SEC23IP for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR004177 DDHD
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021129 SAM_type1

    Graphical View of Domain Structure for InterPro Entry Q9Y6Y8

    ProtoNet protein and cluster: Q9Y6Y8

    1 Blocks protein family: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: S23IP_HUMAN, Q9Y6Y8
    Similarity: Belongs to the PA-PLA1 family
    Similarity: Contains 1 DDHD domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: S23IP_HUMAN, Q9Y6Y8
    Function: Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to
    phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol
    5-phosphate (PI(5)P)

    miRNA
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    miRTarBase miRNAs that target SEC23IP:
    hsa-mir-1 (MIRT001336)

    OriGene 3'-UTR Clone: SEC23IP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC23IP
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC23IP (see all 65):
    hsa-miR-411* hsa-miR-549 hsa-miR-607 hsa-miR-146a hsa-miR-485-3p hsa-miR-30d hsa-miR-374a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidSEC23IP 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC23IP

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC23IP 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC23IP

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--


    SEC23IP for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SEC23IP:
     Decreased cilium length  Decreased cilium length after  

    Animal Models:
         Mouse knock-out Sec23iptm1.1Katn for SEC23IP
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sec23ip):
     no phenotypic analysis  reproductive system 

    SEC23IP for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEC23IP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/11 Interacting proteins for SEC23IP (Q9Y6Y83 ENSP000003580714) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    POLD4Q9HCU83, ENSP000003113684I2D: score=2 STRING: ENSP00000311368
    CLK1P497593I2D: score=1 
    IP6K3Q96PC23I2D: score=1 
    ITGB2P051073I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport TAS10400679
    GO:0007030Golgi organization TAS10400679


    SEC23IP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEC23IP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC23IP
    3 Novoseek chemical compound relationships for SEC23IP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostaglandin f2alpha 59.5 1 10893233 (1)
    tyrosine 54 13 8314789 (2), 10585482 (1), 15174097 (1), 10652210 (1) (see all 10)
    calcium 20 2 8666584 (1)

    Search CenterWatch for drugs/clinical trials and news about SEC23IP / S23IP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC23IP gene: 
    NM_007190.3  

    Unigene Cluster for SEC23IP:

    SEC23 interacting protein
    Hs.435004  [show with all ESTs]
    Unigene Representative Sequence: NM_007190
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369075(uc001leu.2 uc010qtc.2 uc009xzk.2) ENST00000470478
    ENST00000442952 ENST00000446561 ENST00000462222 ENST00000475542 ENST00000483890
    ENST00000543134

    miRNA
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    OriGene 3'-UTR Clone: SEC23IP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC23IP
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC23IP (see all 65):
    hsa-miR-411* hsa-miR-549 hsa-miR-607 hsa-miR-146a hsa-miR-485-3p hsa-miR-30d hsa-miR-374a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidSEC23IP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC23IP (see all 7)
    OriGene shRNA RFP: SEC23IP
    OriGene siRNA: SEC23IP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC23IP
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC23IP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC23IP (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEC23IP (NM_007190)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC23IP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC23IP 
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC23IP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC23IP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC23IP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC23IP

    Additional cDNA sequence: 

    AB019435.1 AK000698.1 AK001135.1 AK021846.1 AK023238.1 AK301517.1 AK307286.1 AK314592.1 
    AL832521.1 BC002540.2 BC063800.1 BT006755.1 BX649119.1 NR_037771.1 

    21 DOTS entries:

    DT.214789  DT.100820547  DT.100820548  DT.95228347  DT.100820545  DT.40126195  DT.100820546  DT.121268561 
    DT.40122871  DT.40274000  DT.95228354  DT.121268558  DT.91752409  DT.100729609  DT.95126966  DT.95198651 
    DT.121268437  DT.121268550  DT.95358898  DT.97861929  DT.92058583 

    24/311 AceView cDNA sequences (see all 311):

    AU102485 AU098378 AW178300 BM505218 CA427409 BP364535 CB990785 AA884713 
    CR619756 AL043488 BC002540 BC063800 BP355532 CB994752 BT006755 BU628561 
    BM055172 BM931940 BF197752 AI373493 CA844062 AA279964 AW178313 BQ437131 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SEC23IP (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:              -                                               -                                                                 -     -                     
    SP2:              -                 -     -     -     -     -     -     -     -                                                     -     -                     
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                                                                            

    ExUns: 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
    SP1:              -                             -                                             
    SP2:              -                                                                           
    SP3:              -                                                                           
    SP4:  -     -     -                             -                                             
    SP5:              -                             -                                             


    ECgene alternative splicing isoforms for SEC23IP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC23IP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAATTTTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SEC23IP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC23IP

    SOURCE GeneReport for Unigene cluster: Hs.435004

    UniProtKB/Swiss-Prot: S23IP_HUMAN, Q9Y6Y8
    Tissue specificity: Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle

        SABiosciences Custom PCR Arrays for SEC23IP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC23IP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SEC23IP gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec23ip1 , 5 Sec23 interacting protein1, 5 84.97(n)1
    86.95(a)1
      7 (70.51 cM)5
    2073521  NM_001029982.21  NP_001025153.21 
     1287448705 
    chicken
    (Gallus gallus)
    Aves SEC23IP1 SEC23 interacting protein 74.12(n)
    76.22(a)
      423934  XM_421794.3  XP_421794.3 
    lizard
    (Anolis carolinensis)
    Reptilia SEC23IP6
    --
    72(a)
    1 ↔ 1
    3(66139227-66170633)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.174542 Xenopus laevis transcribed sequence with weak similarity more 74.47(n)    BJ619249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sec23ip1 SEC23 interacting protein 64.71(n)
    67.51(a)
      560750  NM_001077379.1  NP_001070847.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85521 CG8552 47.7(n)
    41.46(a)
      34109  NM_135341.1  NP_609185.1 


    ENSEMBL Gene Tree for SEC23IP (if available)
    TreeFam Gene Tree for SEC23IP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC23IP gene
    DDHD22  DDHD12  
    1 SIMAP similar gene for SEC23IP using alignment to 4 protein entries:     S23IP_HUMAN (see all proteins):
    DDHD2

    SEC23IP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1045 NCBI SNPs in SEC23IP are shown (see all 1045    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164502971,2
    F,--121650097(+) CCAATA/C/TAGCGC 2 -- us2k11WA 118
    rs1854639391,2
    --121650100(+) ATCAGC/TGCTCT 2 -- us2k10--------
    rs24753081,2
    C,A,--121650101(-) CAGAGC/TGCTGA 2 -- us2k14Minor allele frequency- T:0.42NA WA EA 360
    rs1495050191,2
    --121650227(+) TCTTTC/TGCTCT 2 -- us2k10--------
    rs1441774111,2
    --121650491(+) CACCAC/TTGCTT 2 -- us2k10--------
    rs774594421,2
    C,F,--121650546(+) TTAACA/CCACCC 2 -- us2k11Minor allele frequency- C:0.18EA 120
    rs767736251,2
    --121650616(+) ACACCA/CCAGCC 2 -- us2k10--------
    rs1181670911,2
    --121650656(+) CAAAGT/CTGTGT 2 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1875179091,2
    --121650730(+) TTTAAC/TGAGTG 2 -- us2k10--------
    rs757734211,2
    C,F,--121650752(+) AAATTT/CTTCTT 2 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for SEC23IP (121652223 - 121702014 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SEC23IP: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEC23IP for disorders           About GeneDecksing

    4 diseases for SEC23IP:    About MalaCards
    waardenburg's syndrome    nodular malignant melanoma    alzheimer's disease    melanoma

    1 disease from the University of Copenhagen DISEASES database for SEC23IP:
    Nodular malignant melanoma
    Human Genome Epidemiology (HuGE) Navigator: SEC23IP (2 documents)

    Export disorders for SEC23IP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC23IP gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with SEC23IP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins. (PubMed id 10400679)1, 2, 3 Tani K.... Tagaya M. (1999)
    2. p125 is localized in endoplasmic reticulum exit sites and involved in their organization. (PubMed id 15623529)1, 2, 9 Shimoi W.... Tani K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein. (PubMed id 11112430)1, 9 Mizoguchi T....Tani K. (2000)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Roles of SAM and DDHD domains in mammalian intracellul ar phospholipase A1 KIAA0725p. (PubMed id 22922100)2 Inoue H....Tani K. (2012)
    8. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1 Al-Hakim A.K....Pelletier L. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11196 HGNC: 17018 AceView: SEC23IP Ensembl:ENSG00000107651 euGenes: HUgn11196
    ECgene: SEC23IP H-InvDB: SEC23IP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC23IP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC23IP gene:
    Search GeneIP for patents involving SEC23IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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     Regulatory tfbs in SEC23IP promoter
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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