SEC23B Gene
protein-coding GIFtS: 60
GCID: GC20P018488
|
|
Sec23 homolog B (S. cerevisiae)(Previous names: Sec23 (S. cerevisiae) homolog B, congenital dyserythropoietic...)
(Previous symbol: CDAN2)
| |
Aliases
for SEC23B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sec23 Homolog B (S. Cerevisiae)1 2 | | Congenital Dyserythropoietic Anemia, Type II1 | | CDAN21 2 5 | | Sec23 (S. Cerevisiae) Homolog B1 | | HEMPAS1 2 5 | | Protein Transport Protein Sec23B2 | | CDA-II1 2 | | SEC23-Like Protein B2 | | CDAII1 2 | | Transport Protein SEC23B2 | | SEC23-Related Protein B2 3 | | |
Export aliases for SEC23B gene to outside databasesPrevious GC identifers: GC20P018476 GC20P018483 GC20P018437 GC20P018439 GC20P018441 GC20P018444 GC20P018447 GC20P018452 |
Summaries
for SEC23B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEC23B:
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved invesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat proteincomplex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargoselection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene.(provided by RefSeq, Feb 2010)
UniProtKB/Swiss-Prot: SC23B_HUMAN, Q15437Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmicreticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane,and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity)
Gene Wiki entry for SEC23B
|
Genomic Views
for SEC23B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEC23B gene promoter:
STAT5B Nkx2-5 RORalpha2 GATA-2 AREB6 CBF-B CBF-A CP1A CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEC23B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC23B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.23 Ensembl cytogenetic band: 20p11.23 HGNC cytogenetic band: 20p11.23SEC23B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P018488: view genomic region
(about GC identifiers)
Start:
|
18,488,137 bp from pter |
End:
|
18,542,059 bp from pter |
Size:
|
53,923 bases |
Orientation:
|
plus strand |
|
Proteins
for SEC23B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SC23B_HUMAN, Q15437 (See
protein sequence)Recommended Name: Protein transport protein Sec23B Size: 767 amino acids; 86479 Da
Subunit: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (Bysimilarity)
Subcellular location: Golgi apparatus membrane (By similarity). Endoplasmic reticulum membrane (By similarity).Endoplasmic reticulum-Golgi intermediate compartment membrane (By similarity)
Secondary accessions: D3DW33 Q503A9 Q5W183 Q9BS15 Q9BSI2 Q9H1D7Explore the universe of human proteins at neXtProt for SEC23B: NX_Q15437
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15437
SEC23B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001166216.1 NP_001166217.1 NP_006354.2 NP_116780.1 NP_116781.1
ENSEMBL proteins: ENSP00000403971 ENSP00000262544 ENSP00000338844 ENSP00000366695 ENSP00000366685 ENSP00000409882
Human Recombinant Protein Products for SEC23B:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
SEC23B for ontologies About GeneDecksing
SEC23B Antibody Products:
Assay Products for SEC23B: |
Protein
Domains /
Families
for SEC23B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEC23B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15437ProtoNet protein and cluster: Q15437 4 Blocks protein families: IPB006895 Sec23/Sec24 zinc finger IPB006896 Sec23/Sec24 trunk domain IPB006900 Sec23/Sec24 helical domain IPB007123 Gelsolin region
UniProtKB/Swiss-Prot: SC23B_HUMAN, Q15437Similarity: Belongs to the SEC23/SEC24 family. SEC23 subfamily |
Function
for SEC23B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SC23B_HUMAN, Q15437Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmicreticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane,and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
SEC23B for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for SEC23B:
11 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Sec23b):
SEC23B for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC23B (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC23B (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): SEC23B (NM_006363) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC23B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC23B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC23B |
|
Pathways & Interactions
for SEC23B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin-dependent protein traffic | | | 2 | COPII (Coat Protein 2) Mediated Vesicle Transport | | | 3 | Protein processing in endoplasmic reticulum | | | 4 | Regulation of Cholesterol Biosynthesis by SREBP (SREBF) | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SEC23B
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEC23B
4  GeneGo (Thomson Reuters) Pathways for SEC23B
1  BioSystems Pathway for SEC23B
1 
Kegg Pathway (Kegg details for SEC23B):
SEC23B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC23B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/620 Interacting proteins for SEC23B (Q154372, 3 ENSP000002625444) via UniProtKB, MINT, STRING, and/or I2D (see all 620)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006886 | intracellular protein transport |
IEA | -- | | GO:0006888 | ER to Golgi vesicle-mediated transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
TAS | 8898360 |
SEC23B for ontologies About GeneDecksing
|
Drugs & Compounds
for SEC23B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEC23B
Search CenterWatch for drugs/clinical trials and news about SEC23B / SC23B
|
Transcripts
for SEC23B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEC23B gene (5 alternative transcripts): NM_001172745.1 NM_001172746.1 NM_006363.4 NM_032985.4 NM_032986.3 Unigene Cluster for SEC23B: Sec23 homolog B (S. cerevisiae) Hs.369373 [show with all ESTs]Unigene Representative Sequence: NM_0329858 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450074 ENST00000262544 ENST00000336714(uc010zsb.2 uc002wra.2 uc002wrb.2 uc002wqz.2)
ENST00000377475 ENST00000474619 ENST00000377465(uc002wrc.2) ENST00000494645
ENST00000422877
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC23B (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC23B (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): SEC23B (NM_006363) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC23B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC23B |
Additional cDNA sequence: AK296270.1 AK299171.1 BC001151.1 BC001575.1 BC005032.1 BC005404.1 BC095404.1 X97065.1 21 DOTS entries: DT.95229103 DT.95154176 DT.100827989 DT.404422 DT.92449091 DT.120829868 DT.95154172 DT.102831487 DT.100827986 DT.120829870 DT.100827994 DT.120829852 DT.100737488 DT.100827990 DT.100827998 DT.100828000 DT.91892657 DT.92449108 DT.95154173 DT.95154177 DT.40233612 24/368 AceView cDNA sequences (see all 368): AI261619 AA634360 BM471654 T34277 BQ644118 BG261063 BM756308 CA487782 N73718 BM473799 BU159069 CN482478 AA331500 AI371199 BU508952 BM786209 BM834020 CA488609 NM_032986 BI087115 BQ182360 BQ011410 AU130930 BE835189
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SEC23B (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | · | 25c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SEC23B
|
Expression
for SEC23B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEC23B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SEC23B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC23B
SOURCE GeneReport for Unigene cluster: Hs.369373
SABiosciences Custom PCR Arrays for SEC23B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC23B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC23B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC23B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC23B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC23B |
Orthologs
for SEC23B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SEC23B gene from 9/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Sec23b1 , 5 |
SEC23B (S. cerevisiae)1, 5 |
90.64(n)1
97.26(a)1 |
|
2 (71.02 cM)5
270541 NM_019787.41 NP_062761.21
1445562295 |
chicken
(Gallus gallus) |
Aves |
SEC23B1 |
Sec23 homolog B (S. cerevisiae) |
79.77(n)
93.21(a) |
|
416724 NM_001006179.1 NP_001006179.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SEC23B6 |
-- |
92(a) |
1 ↔ 1 |
4(79952615-79970498) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BX849742.12 |
-- |
78.48(n) |
|
BX849742.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC045394.12 |
-- |
76.9(n) |
|
327268 BC045394.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
sec233 |
ER to Golgi transport GTPase activator |
71(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
sec-233 |
-- |
62(a) |
|
V(20083371-20097668) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G216301 |
sec23/sec24-like transport protein |
52.06(n)
45.7(a) |
|
816701 NM_127734.2 NP_179757.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.99632 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73(n) |
|
AK064878.1 |
ENSEMBL Gene Tree for SEC23B (if available)
TreeFam Gene Tree for SEC23B (if available) |
Paralogs
for SEC23B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEC23B gene
- SEC23A2
1 SIMAP similar gene for SEC23B using alignment to 3 protein entries: SC23B_HUMAN (see all proteins):SEC23A
SEC23B for paralogs About GeneDecksing
|
Genomic Variants
for SEC23B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEC23B (18488137 - 18542059 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEC23B: --
Human Gene Mutation Database (HGMD): SEC23B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC23B |
|
Disorders
/ Diseases
for SEC23B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SEC23B for disorders About GeneDecksing
OMIM gene information: 610512
OMIM disorders: 224100
UniProtKB/Swiss-Prot: SC23B_HUMAN, Q15437
Defects in SEC23B are the cause of congenital dyserythropoietic anemia type 2 (CDA2) [MIM:224100]. Anautosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffectiveerythropoiesis, normocytic anemia, iron overload, jaundice, and variable splenomegaly. Ultrastructural featuresinclude bi- or multinucleated erythroblasts in bone marrow, karyorrhexis, and the presence of Gaucher-like bone marrowhistiocytes. The main biochemical feature of the disease is defective glycosylation of some red blood cells membraneproteins
10  diseases for SEC23B: About MalaCardscongenital dyserythropoietic anemia dyserythropoietic anemia anemia congenital dyserythropoietic anemia ii
iron overload siderosis blood disorders splenomegaly
jaundice malaria
2 diseases from the University of Copenhagen DISEASES database for SEC23B:Anemia Siderosis Human Genome Epidemiology (HuGE) Navigator: SEC23B (2 documents)
Export disorders for SEC23B gene to outside databases
|
Publications
for SEC23B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEC23B gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with SEC23B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Congenital dyserythropoietic anemia type II (CDAII) i s caused by mutations in the SEC23B gene. (PubMed id 19621418)1, 2, 3, 9 Bianchi P....Zanella A. (2009)
- Cloning and functional characterization of mammalian homologues of the COPII component Sec23. (PubMed id 8898360)1, 2, 3 Paccaud J.-P.... Orci L. (1996)
- Mutations affecting the secretory COPII coat componen t SEC23B cause congenital dyserythropoietic anemia type II. (PubMed id 19561605)1, 2 Schwarz K....Heimpel H. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A family of mammalian proteins homologous to yeast Sec24p. (PubMed id 10329445)1, 3 Tang B.L....Hong W. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation. (PubMed id 22267732)1 de Castro R.O....Siraganian R.P. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
|
External Searches for SEC23B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SEC23B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SEC23B gene
(According to HUGE)
About This Section
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Specialized Databases showing SEC23B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SEC23B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SEC23B gene:
Search GeneIP for patents involving SEC23B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SEC23B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SEC23B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC23B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC23B | | | OriGene Protein Over-expression Lysate for SEC23B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SEC23B | | OriGene 3'-UTR Clone for SEC23B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC23B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC23B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SEC23B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SEC23B | | OriGene Custom Protein Services for SEC23B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC23B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC23B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC23B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC23B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC23B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC23B |
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| | | | Search Tocris compounds for SEC23B |
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 | | | SEC23B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC23B |
|  |  |  |  | | | | ThermoFisher Antibodies for SEC23B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC23B |
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