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Aliases for SEC23A Gene

Aliases for SEC23A Gene

  • Sec23 Homolog A (S. Cerevisiae) 2 3
  • SEC23-Related Protein A 3 4
  • CLSD 3 6
  • Protein Transport Protein Sec23A 3
  • Sec23 (S. Cerevisiae) Homolog A 2

External Ids for SEC23A Gene

Summaries for SEC23A Gene

Entrez Gene Summary for SEC23A Gene

  • The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC23A Gene

SEC23A (Sec23 Homolog A (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with SEC23A include craniolenticulosutural dysplasia. Among its related pathways are Class I MHC mediated antigen processing and presentation and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). An important paralog of this gene is SEC23B.

UniProtKB/Swiss-Prot for SEC23A Gene

  • Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for SEC23A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC23A Gene

Genomics for SEC23A Gene

Genomic Location for SEC23A Gene

Start:
39,031,919 bp from pter
End:
39,109,646 bp from pter
Size:
77,728 bases
Orientation:
Minus strand

Genomic View for SEC23A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC23A Gene

Regulatory Elements for SEC23A Gene

Proteins for SEC23A Gene

  • Protein details for SEC23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15436-SC23A_HUMAN
    Recommended name:
    Protein transport protein Sec23A
    Protein Accession:
    Q15436
    Secondary Accessions:
    • B2R5P4
    • B3KXI2
    • Q8NE16

    Protein attributes for SEC23A Gene

    Size:
    765 amino acids
    Molecular mass:
    86161 Da
    Quaternary structure:
    • COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4 (By similarity). Interacts with SLC6A4 (By similarity). Interacts with SEC16A.

    Three dimensional structures from OCA and Proteopedia for SEC23A Gene

    Alternative splice isoforms for SEC23A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC23A Gene

Proteomics data for SEC23A Gene at MOPED

Post-translational modifications for SEC23A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys46 and Lys669

Other Protein References for SEC23A Gene

No data available for DME Specific Peptides for SEC23A Gene

Domains for SEC23A Gene

UniProtKB/Swiss-Prot:

SC23A_HUMAN
Family:
  • Belongs to the SEC23/SEC24 family. SEC23 subfamily.:
    • Q15436
genes like me logo Genes that share domains with SEC23A: view

No data available for Gene Families for SEC23A Gene

Function for SEC23A Gene

Molecular function for SEC23A Gene

UniProtKB/Swiss-Prot Function: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex

Gene Ontology (GO) - Molecular Function for SEC23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10075675
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SEC23A: view

Phenotypes for SEC23A Gene

MGI mutant phenotypes for SEC23A:
inferred from 1 alleles
GenomeRNAi human phenotypes for SEC23A:
genes like me logo Genes that share phenotypes with SEC23A: view

miRNA for SEC23A Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC23A Gene

Localization for SEC23A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC23A Gene

Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=In the ribosome-free transitional face of the ER and associated vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC23A Gene COMPARTMENTS Subcellular localization image for SEC23A gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 4
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEC23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum TAS 8898360
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
genes like me logo Genes that share ontologies with SEC23A: view

Pathways for SEC23A Gene

genes like me logo Genes that share pathways with SEC23A: view

Pathways by source for SEC23A Gene

1 Qiagen pathway for SEC23A Gene
1 Cell Signaling Technology pathway for SEC23A Gene

Gene Ontology (GO) - Biological Process for SEC23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0016192 vesicle-mediated transport TAS 8898360
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with SEC23A: view

Transcripts for SEC23A Gene

Unigene Clusters for SEC23A Gene

Sec23 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC23A Gene

No ASD Table

Relevant External Links for SEC23A Gene

GeneLoc Exon Structure for
SEC23A
ECgene alternative splicing isoforms for
SEC23A

Expression for SEC23A Gene

mRNA expression in normal human tissues for SEC23A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC23A Gene

SOURCE GeneReport for Unigene cluster for SEC23A Gene Hs.272927

genes like me logo Genes that share expressions with SEC23A: view

Orthologs for SEC23A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC23A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC23A 36
  • 99.65 (n)
  • 99.87 (a)
SEC23A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC23A 36
  • 94.33 (n)
  • 99.47 (a)
SEC23A 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC23A 36
  • 95.03 (n)
  • 99.48 (a)
SEC23A 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec23a 36
  • 91.24 (n)
  • 98.95 (a)
Sec23a 16
Sec23a 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC23A 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sec23a 36
  • 91.29 (n)
  • 98.95 (a)
chicken
(Gallus gallus)
Aves SEC23A 36
  • 83.36 (n)
  • 96.21 (a)
SEC23A 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC23A 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec23a 36
  • 79.08 (n)
  • 93.33 (a)
zebrafish
(Danio rerio)
Actinopterygii sec23a 36
  • 76.3 (n)
  • 90.98 (a)
sec23a 37
  • 91 (a)
OneToOne
wufc10f08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001759 36
  • 63.13 (n)
  • 74.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec23 36
  • 65.04 (n)
  • 75.63 (a)
sec23 37
  • 73 (a)
OneToMany
sec23 38
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea sec-23 36
  • 59.49 (n)
  • 60.76 (a)
sec-23 37
  • 56 (a)
OneToMany
sec-23 38
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL272W 36
  • 53.44 (n)
  • 52.41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC23 36
  • 53.66 (n)
  • 51.13 (a)
SEC23 37
  • 50 (a)
OneToMany
SEC23 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04885g 36
  • 54.51 (n)
  • 51.74 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G21630 36
  • 53.6 (n)
  • 47.73 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12907 36
corn
(Zea mays)
Liliopsida Zm.7720 36
rice
(Oryza sativa)
Liliopsida Os08g0474700 36
  • 53.46 (n)
  • 47.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01318 36
  • 56.66 (n)
  • 58.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec231 36
  • 58.14 (n)
  • 57.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1036 37
  • 74 (a)
OneToMany
Species with no ortholog for SEC23A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC23A Gene

ENSEMBL:
Gene Tree for SEC23A (if available)
TreeFam:
Gene Tree for SEC23A (if available)

Paralogs for SEC23A Gene

Paralogs for SEC23A Gene

genes like me logo Genes that share paralogs with SEC23A: view

Variants for SEC23A Gene

Sequence variations from dbSNP and Humsavar for SEC23A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1135659 -- 39,037,536(-) aaaaa(A/G)aaaaa intron-variant
rs1555257 -- 39,038,863(-) TAGGA(A/C)AAAAG intron-variant
rs1884383 -- 39,078,422(-) TTTGG(G/T)CATCC intron-variant
rs1884384 -- 39,045,027(-) CTATT(A/T)ATGTA intron-variant
rs1884385 -- 39,039,403(-) CAAGT(A/G)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC23A Gene

Variant ID Type Subtype PubMed ID
esv259479 OTHER Complex 20981092
esv259821 OTHER Complex 20981092
nsv85298 CNV Insertion 16902084
esv8908 CNV Gain 19470904
nsv85182 CNV Insertion 16902084
esv273969 CNV Insertion 20981092
esv268040 CNV Insertion 20981092
esv997844 CNV Insertion 20482838
nsv85230 CNV Loss 16902084
esv1683314 CNV Deletion 17803354

Relevant External Links for SEC23A Gene

HapMap Linkage Disequilibrium report
SEC23A
Human Gene Mutation Database (HGMD)
SEC23A

Disorders for SEC23A Gene

(1) OMIM Diseases for SEC23A Gene (610511)

UniProtKB/Swiss-Prot

SC23A_HUMAN
  • Craniolenticulosutural dysplasia (CLSD) [MIM:607812]: Autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects. {ECO:0000269 PubMed:16980979}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SEC23A Gene

Relevant External Links for SEC23A

Genetic Association Database (GAD)
SEC23A
Human Genome Epidemiology (HuGE) Navigator
SEC23A
genes like me logo Genes that share disorders with SEC23A: view

Publications for SEC23A Gene

  1. Cloning and functional characterization of mammalian homologues of the COPII component Sec23. (PMID: 8898360) Paccaud J.-P. … Orci L. (Mol. Biol. Cell 1996) 2 3 4
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  3. A family of mammalian proteins homologous to yeast Sec24p. (PMID: 10329445) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1999) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SEC23A Gene

Sources for SEC23A Gene

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