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Aliases for SEC22C Gene

Aliases for SEC22C Gene

  • SEC22 Homolog C, Vesicle Trafficking Protein 2 3 5
  • SEC22L3 3 4
  • SEC22 Vesicle Trafficking Protein Homolog C (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like 3 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like Protein C 3
  • SEC22 Vesicle Trafficking Protein Homolog C 3
  • SEC22 Vesicle-Trafficking Protein Homolog C 4
  • SEC22 Vesicle Trafficking Protein-Like 3 3
  • SEC22 Vesicle-Trafficking Protein-Like 3 4
  • Secretion Deficient 22C 3

External Ids for SEC22C Gene

Previous HGNC Symbols for SEC22C Gene

  • SEC22L3

Previous GeneCards Identifiers for SEC22C Gene

  • GC03M041894
  • GC03M042565

Summaries for SEC22C Gene

Entrez Gene Summary for SEC22C Gene

  • This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for SEC22C Gene

SEC22C (SEC22 Homolog C, Vesicle Trafficking Protein) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is SEC22B.

UniProtKB/Swiss-Prot for SEC22C Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22C Gene

Genomics for SEC22C Gene

Regulatory Elements for SEC22C Gene

Enhancers for SEC22C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEC22C on UCSC Golden Path with GeneCards custom track

Promoters for SEC22C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC22C on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SEC22C gene promoter:

Genomic Location for SEC22C Gene

42,547,967 bp from pter
42,601,080 bp from pter
53,114 bases
Minus strand

Genomic View for SEC22C Gene

Genes around SEC22C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22C Gene

Proteins for SEC22C Gene

  • Protein details for SEC22C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle-trafficking protein SEC22c
    Protein Accession:
    Secondary Accessions:
    • O95152
    • Q68CX3
    • Q6UW18

    Protein attributes for SEC22C Gene

    303 amino acids
    Molecular mass:
    34269 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEC22C Gene


neXtProt entry for SEC22C Gene

Proteomics data for SEC22C Gene at MOPED

Post-translational modifications for SEC22C Gene

  • Ubiquitination at Lys 297
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC22C Gene

Domains & Families for SEC22C Gene

Gene Families for SEC22C Gene

Protein Domains for SEC22C Gene


Suggested Antigen Peptide Sequences for SEC22C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 longin domain.
  • Belongs to the synaptobrevin family.
  • Contains 1 longin domain.
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22C: view

Function for SEC22C Gene

Molecular function for SEC22C Gene

UniProtKB/Swiss-Prot Function:
May be involved in vesicle transport between the ER and the Golgi complex.

Gene Ontology (GO) - Molecular Function for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
genes like me logo Genes that share ontologies with SEC22C: view
genes like me logo Genes that share phenotypes with SEC22C: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC22C Gene

Localization for SEC22C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SEC22C Gene COMPARTMENTS Subcellular localization image for SEC22C gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 2
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for SEC22C Gene

Pathways & Interactions for SEC22C Gene

genes like me logo Genes that share pathways with SEC22C: view

Gene Ontology (GO) - Biological Process for SEC22C Gene


No data available for SIGNOR curated interactions for SEC22C Gene

Drugs & Compounds for SEC22C Gene

No Compound Related Data Available

Transcripts for SEC22C Gene

Unigene Clusters for SEC22C Gene

SEC22 vesicle trafficking protein homolog C (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - - -

ExUns: 13 ^ 14 ^ 15
SP1: -
SP5: - -

Relevant External Links for SEC22C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC22C Gene

mRNA expression in normal human tissues for SEC22C Gene

SOURCE GeneReport for Unigene cluster for SEC22C Gene Hs.445892

mRNA Expression by UniProt/SwissProt for SEC22C Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SEC22C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SEC22C Gene

Orthologs for SEC22C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEC22C 35
  • 90.32 (n)
  • 92.08 (a)
SEC22C 36
  • 92 (a)
(Canis familiaris)
Mammalia SEC22C 35
  • 91.2 (n)
  • 90.76 (a)
SEC22C 36
  • 91 (a)
(Mus musculus)
Mammalia Sec22c 35
  • 83.83 (n)
  • 81.52 (a)
Sec22c 16
Sec22c 36
  • 82 (a)
(Pan troglodytes)
Mammalia SEC22C 35
  • 99.56 (n)
  • 99.67 (a)
SEC22C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC687022 35
  • 74.64 (n)
  • 71.04 (a)
(Monodelphis domestica)
Mammalia SEC22C 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia SEC22C 36
  • 65 (a)
(Gallus gallus)
Aves SEC22C 35
  • 71.18 (n)
  • 67.33 (a)
SEC22C 36
  • 68 (a)
(Anolis carolinensis)
Reptilia SEC22C 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22c 35
  • 61.36 (n)
  • 56.27 (a)
(Danio rerio)
Actinopterygii sec22c 35
  • 59.19 (n)
  • 49.83 (a)
sec22c 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sec22 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea sec-22 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for SEC22C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22C Gene

Gene Tree for SEC22C (if available)
Gene Tree for SEC22C (if available)

Paralogs for SEC22C Gene

Paralogs for SEC22C Gene

(1) SIMAP similar genes for SEC22C Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SEC22C: view

Variants for SEC22C Gene

Sequence variations from dbSNP and Humsavar for SEC22C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs704979 -- 42,596,172(-) TGGTG(C/G)CACAT intron-variant
rs342534 -- 42,550,464(-) TCATC(C/T)GAGGG intron-variant, utr-variant-3-prime
rs342535 -- 42,550,646(-) GATAT(C/T)AGTTA intron-variant, utr-variant-3-prime
rs342536 -- 42,550,827(-) TTCCT(A/G)TGTGG intron-variant, utr-variant-3-prime
rs342537 -- 42,551,382(-) CCTGC(A/G)TGACA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEC22C Gene

Variant ID Type Subtype PubMed ID
esv2678489 CNV Deletion 23128226

Variation tolerance for SEC22C Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SEC22C Gene

Disorders for SEC22C Gene

Relevant External Links for SEC22C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC22C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22C Gene

Publications for SEC22C Gene

  1. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Protein phosphatase 2B inhibition promotes the secretion of von Willebrand factor from endothelial cells. (PMID: 19344364) Nolasco L.H. … Vijayan K.V. (J. Thromb. Haemost. 2009) 23

Products for SEC22C Gene

Sources for SEC22C Gene