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SEC22C Gene

protein-coding   GIFtS: 46
GCID: GC03M042589

SEC22 Vesicle Trafficking Protein Homolog C (S. Cerevisiae)

(Previous name: SEC22 vesicle trafficking protein-like 3 (S. cerevisiae))
(Previous symbol: SEC22L3)
  Search for SEC22C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SEC22 Vesicle Trafficking Protein Homolog C (S. Cerevisiae)1 2     Secretion Deficient 22C2
SEC22L31 2 3     Vesicle-Trafficking Protein SEC22c2
SEC22 Vesicle Trafficking Protein-Like 3 (S. Cerevisiae)1     SEC22 Vesicle-Trafficking Protein Homolog C3
SEC22 Vesicle Trafficking Protein-Like 32     SEC22 Vesicle-Trafficking Protein-Like 33

External Ids:    HGNC: 168281   Entrez Gene: 91172   Ensembl: ENSG000000931837   OMIM: 6040285   UniProtKB: Q9BRL73   

Export aliases for SEC22C gene to outside databases

Previous GC identifers: GC03M041894 GC03M042565


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEC22C Gene:
This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized
to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided
by RefSeq, Jan 2011)

GeneCards Summary for SEC22C Gene:
SEC22C (SEC22 vesicle trafficking protein homolog C (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is SEC22A.

UniProtKB/Swiss-Prot: SC22C_HUMAN, Q9BRL7
Function: May be involved in vesicle transport between the ER and the Golgi complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC22C gene promoter:
         HEN1   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEC22C promoter sequence
   Search Chromatin IP Primers for SEC22C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC22C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p24.3-p22.1

SEC22C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC22C gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M042589:  view genomic region     (about GC identifiers)

Start:
42,589,459 bp from pter      End:
42,642,572 bp from pter
Size:
53,114 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SC22C_HUMAN, Q9BRL7 (See protein sequence)
Recommended Name: Vesicle-trafficking protein SEC22c  
Size: 303 amino acids; 34269 Da
Secondary accessions: O95152 Q68CX3 Q6UW18
Alternative splicing: 3 isoforms:  Q9BRL7-1   Q9BRL7-2   Q9BRL7-3   

Explore the universe of human proteins at neXtProt for SEC22C: NX_Q9BRL7

Explore proteomics data for SEC22C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys297
  • Modification sites at PhosphoSitePlus

  • See SEC22C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001188501.1  NP_001188513.1  NP_004197.1  NP_116752.1  

    ENSEMBL proteins: 
     ENSP00000415969   ENSP00000414576   ENSP00000273156   ENSP00000407564   ENSP00000389589  
     ENSP00000264454   ENSP00000391170   ENSP00000373256   ENSP00000397170   ENSP00000404987  
     ENSP00000411725   ENSP00000391957   ENSP00000408242   ENSP00000439845  

    SEC22C Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SEC22C
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEC22C
    GenScript Custom Purified and Recombinant Proteins Services for SEC22C
    Novus Biologicals SEC22C Proteins
    Novus Biologicals SEC22C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC22C

     
    Search eBioscience for Proteins for SEC22C 

    SEC22C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals SEC22C Antibodies
    Search for Antibodies for SEC22C at Abcam
    Cloud-Clone Corp. Antibodies for SEC22C
    Search ThermoFisher Antibodies for SEC22C
    LSBio Antibodies in human, mouse, rat for SEC22C

    SEC22C Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SEC22C
    Cloud-Clone Corp. CLIAs for SEC22C
    Search eBioscience for ELISAs for SEC22C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010908 Longin_dom
     IPR011012 Longin-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9BRL7

    ProtoNet protein and cluster: Q9BRL7

    UniProtKB/Swiss-Prot: SC22C_HUMAN, Q9BRL7
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 longin domain


    Find genes that share domains with SEC22C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC22C_HUMAN, Q9BRL7
    Function: May be involved in vesicle transport between the ER and the Golgi complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IBA--
    GO:0005484SNAP receptor activity IBA--
         
    Find genes that share ontologies with SEC22C           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC22C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC22C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC22C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC22C

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC22C:
    hsa-mir-124-3p (MIRT022353)

    Block miRNA regulation of human, mouse, rat SEC22C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEC22C (see all 25):
    hsa-miR-30c hsa-miR-30d hsa-miR-888* hsa-miR-103a hsa-miR-10b* hsa-miR-548m hsa-miR-30a hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidSEC22C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEC22C
    Predesigned siRNA for gene silencing in human, mouse, rat SEC22C

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SEC22C

    Clone
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    OriGene clones in human, mouse for SEC22C (see all 13)
    OriGene ORF clones in mouse, rat for SEC22C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SEC22C (NM_004206)
    Sino Biological Human cDNA Clone for SEC22C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC22C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC22C

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SEC22C
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEC22C 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC22C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC22C_HUMAN, Q9BRL7: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    golgi apparatus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9501016
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031201SNARE complex IBA--

    Find genes that share ontologies with SEC22C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC22C
    Interactions:

        Search GeneGlobe Interaction Network for SEC22C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC22C (ENSP000002644544) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOSR2ENSP000002255674STRING: ENSP00000225567
    YKT6ENSP000002233694STRING: ENSP00000223369
    SCFD1ENSP000003907834STRING: ENSP00000390783
    RINT1ENSP000002577004STRING: ENSP00000257700
    USE1ENSP000002638974STRING: ENSP00000263897
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006887NOT exocytosis IBA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS9501016
    GO:0015031protein transport IEA--
    GO:0048280vesicle fusion with Golgi apparatus IBA--

    Find genes that share ontologies with SEC22C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC22C (SC22C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEC22C gene (4 alternative transcripts): 
    NM_001201572.1  NM_001201584.1  NM_004206.3  NM_032970.3  

    Unigene Cluster for SEC22C:

    SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
    Hs.445892  [show with all ESTs]
    Unigene Representative Sequence: NM_032970
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451653(uc003clj.3) ENST00000423701 ENST00000273156(uc003clh.3 uc010hic.3 uc011azo.2)
    ENST00000417572(uc003cli.3) ENST00000449617 ENST00000264454 ENST00000456515
    ENST00000493107 ENST00000383750 ENST00000450981 ENST00000445388 ENST00000454141
    ENST00000416880 ENST00000487701 ENST00000420163 ENST00000456222 ENST00000536332

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEC22C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEC22C (see all 25):
    hsa-miR-30c hsa-miR-30d hsa-miR-888* hsa-miR-103a hsa-miR-10b* hsa-miR-548m hsa-miR-30a hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidSEC22C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEC22C
    Predesigned siRNA for gene silencing in human, mouse, rat SEC22C
    Clone
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    OriGene clones in human, mouse for SEC22C (see all 13)
    OriGene ORF clones in mouse, rat for SEC22C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SEC22C (NM_004206)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC22C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC22C
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEC22C
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC22C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC22C
      QuantiTect SYBR Green Assays in human, mouse, rat SEC22C
      QuantiFast Probe-based Assays in human, mouse, rat SEC22C

    Additional mRNA sequence: 

    AF039568.1 AK074576.1 AK292856.1 AK293133.1 AY359041.1 BC006178.1 BC018437.1 CR749670.1 

    17 DOTS entries:

    DT.100024662  DT.100789027  DT.415411  DT.100774722  DT.100675624  DT.95303168  DT.97776290  DT.100742609 
    DT.120908124  DT.120908200  DT.120908182  DT.100774721  DT.102843513  DT.120908176  DT.75172280  DT.120908144 
    DT.92426366 

    Selected AceView cDNA sequences (see all 260):

    AI142871 AI922673 AK074576 BM310071 CA443113 AI304838 AW614723 BI837380 
    AA587335 AI784503 BU633359 NM_032970 CR595143 AL120708 BM700087 CR606001 
    BM849269 BU737888 BM126280 BX103947 BM996144 BM310340 AW516228 NM_004206 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEC22C (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^
    SP1:                                                              -     -                 -     -     -     -     -                                             
    SP2:                                                              -     -                 -     -     -     -     -                                             
    SP3:              -     -     -     -     -     -     -     -     -     -                 -     -     -     -     -                                             
    SP4:                                                              -     -                 -     -     -     -     -                                             
    SP5:                                                              -     -                 -     -     -     -     -                                             

    ExUns: 13 ^ 14 ^ 15
    SP1:        -         
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:  -     -         


    ECgene alternative splicing isoforms for SEC22C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEC22C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACACAAGC
    SEC22C Expression
    About this image

    SEC22C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC22C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445892

    UniProtKB/Swiss-Prot: SC22C_HUMAN, Q9BRL7
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for SEC22C
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    QuantiTect SYBR Green Assays in human, mouse, rat SEC22C
    QuantiFast Probe-based Assays in human, mouse, rat SEC22C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC22C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC22C gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec22c1 , 5 SEC22 vesicle trafficking protein homolog C (S. cerevisiae)1, 5 83.83(n)1
    81.52(a)1
      9 (72.54 cM)5
    2154741  NM_178677.41  NP_848792.21 
     1216830225 
    chicken
    (Gallus gallus)
    Aves SEC22C1 SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 71.18(n)
    67.33(a)
      420387  XM_004939070.1  XP_004939127.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC22C6
    SEC22 vesicle trafficking protein homolog C (S. ce...
    65(a)
    1 ↔ 1
    6(2611661-2623590)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sec22c1 SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 61.36(n)
    56.27(a)
      100488477  XM_002939307.2  XP_002939353.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sec22c1 SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 59.19(n)
    49.83(a)
      558856  XM_702251.4  XP_707343.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sec226
    --
    22(a)
    1 → many
    X(700109-702233)
    worm
    (Caenorhabditis elegans)
    Secernentea sec-226
    Protein SEC-22 (sec-22) mRNA, complete cds
    23(a)
    1 → many
    X(1035548-1037067) WBGene00018853
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC226
    R-SNARE protein; assembles into SNARE complex with...
    21(a)
    1 → many
    XII(680200-680844) YLR268W


    ENSEMBL Gene Tree for SEC22C (if available)
    TreeFam Gene Tree for SEC22C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEC22C gene
    SEC22A2  
    1 SIMAP similar gene for SEC22C using alignment to 10 protein entries:     SC22C_HUMAN (see all proteins):
    SEC22A

    Find genes that share paralogs with SEC22C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEC22C (see all 792)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1861410041,2
    --42588994(+) GAGGAC/TAGTGC 4 -- ds50010--------
    rs1394151101,2
    --42589018(+) CTGGGA/TATTTT 4 -- ds50010--------
    rs1434099171,2
    --42589038(+) TATAGA/GAACAG 4 -- ds50010--------
    rs794095391,2
    C,F--42589074(+) GGCTGG/CAAACC 4 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1914013331,2
    --42589159(+) CCTTCA/CCAGTA 4 -- ds50010--------
    rs730713781,2
    --42589165(+) CAGTAA/GACAAG 4 -- ds50010--------
    rs1841501171,2
    --42589170(+) GACAAC/GAGCCC 4 -- ds50010--------
    rs1471793581,2
    C--42589175(+) GAGCCC/TAAAAC 4 -- ds50010--------
    rs1403829281,2
    --42589320(+) CCTTGA/CGCCTG 4 -- ds50010--------
    rs771269021,2
    C,F--42589321(+) CTTGCG/ACCTGT 4 -- ds50011Minor allele frequency- A:0.08WA 118

    HapMap Linkage Disequilibrium report for SEC22C (42589459 - 42642572 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SEC22C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678489CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC22C
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC22C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604028    OMIM disorders: --


    Find genes that share disorders with SEC22C           About GenesLikeMe


    Export disorders for SEC22C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEC22C gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SEC22C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PubMed id 9501016)1, 2, 3 Tang B.L.... Hong W. (Biochem. Biophys. Res. Commun. 1998)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Topological restriction of SNARE-dependent membrane fusion. (PubMed id 11001058)3 Parlati F....Rothman J.E. (Nature 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9117 HGNC: 16828 AceView: SEC22L3 Ensembl:ENSG00000093183 euGenes: HUgn9117
    ECgene: SEC22C H-InvDB: SEC22C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SEC22C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SEC22C gene:
    Search GeneIP for patents involving SEC22C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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