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Aliases for SEC22C Gene

Aliases for SEC22C Gene

  • SEC22 Vesicle Trafficking Protein Homolog C (S. Cerevisiae) 2 3
  • SEC22L3 3 4
  • SEC22 Vesicle Trafficking Protein-Like 3 (S. Cerevisiae) 2
  • SEC22 Vesicle-Trafficking Protein Homolog C 4
  • SEC22 Vesicle Trafficking Protein-Like 3 3
  • SEC22 Vesicle-Trafficking Protein-Like 3 4
  • Vesicle-Trafficking Protein SEC22c 3
  • Secretion Deficient 22C 3

External Ids for SEC22C Gene

Previous HGNC Symbols for SEC22C Gene

  • SEC22L3

Previous GeneCards Identifiers for SEC22C Gene

  • GC03M041894
  • GC03M042565

Summaries for SEC22C Gene

Entrez Gene Summary for SEC22C Gene

  • This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for SEC22C Gene

SEC22C (SEC22 Vesicle Trafficking Protein Homolog C (S. Cerevisiae)) is a Protein Coding gene. An important paralog of this gene is SEC22A.

UniProtKB/Swiss-Prot for SEC22C Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22C Gene

Genomics for SEC22C Gene

Regulatory Elements for SEC22C Gene

Transcription factor binding sites by QIAGEN in the SEC22C gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC22C Gene

Start:
42,547,967 bp from pter
End:
42,601,080 bp from pter
Size:
53,114 bases
Orientation:
Minus strand

Genomic View for SEC22C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC22C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22C Gene

Proteins for SEC22C Gene

  • Protein details for SEC22C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRL7-SC22C_HUMAN
    Recommended name:
    Vesicle-trafficking protein SEC22c
    Protein Accession:
    Q9BRL7
    Secondary Accessions:
    • O95152
    • Q68CX3
    • Q6UW18

    Protein attributes for SEC22C Gene

    Size:
    303 amino acids
    Molecular mass:
    34269 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEC22C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC22C Gene

Proteomics data for SEC22C Gene at MOPED

Post-translational modifications for SEC22C Gene

  • Ubiquitination at Lys297
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC22C Gene

Domains for SEC22C Gene

Protein Domains for SEC22C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SEC22C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRL7

UniProtKB/Swiss-Prot:

SC22C_HUMAN :
  • Q9BRL7
Domain:
  • Contains 1 longin domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22C: view

No data available for Gene Families for SEC22C Gene

Function for SEC22C Gene

Molecular function for SEC22C Gene

UniProtKB/Swiss-Prot Function: May be involved in vesicle transport between the ER and the Golgi complex.

Gene Ontology (GO) - Molecular Function for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SEC22C: view

Animal Model Products

CRISPR Products

miRNA for SEC22C Gene

miRTarBase miRNAs that target SEC22C

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC22C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC22C Gene

Localization for SEC22C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC22C Gene COMPARTMENTS Subcellular localization image for SEC22C gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9501016
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with SEC22C: view

Pathways for SEC22C Gene

SuperPathways for SEC22C Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006887 NOT exocytosis IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS 9501016
GO:0015031 protein transport IEA --
GO:0048280 vesicle fusion with Golgi apparatus IBA --
genes like me logo Genes that share ontologies with SEC22C: view

No data available for Pathways by source for SEC22C Gene

Transcripts for SEC22C Gene

Unigene Clusters for SEC22C Gene

SEC22 vesicle trafficking protein homolog C (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC22C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - - -
SP16:

ExUns: 13 ^ 14 ^ 15
SP1: -
SP2:
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for SEC22C Gene

GeneLoc Exon Structure for
SEC22C
ECgene alternative splicing isoforms for
SEC22C

Expression for SEC22C Gene

mRNA expression in normal human tissues for SEC22C Gene

SOURCE GeneReport for Unigene cluster for SEC22C Gene Hs.445892

mRNA Expression by UniProt/SwissProt for SEC22C Gene

Q9BRL7-SC22C_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SEC22C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for SEC22C Gene

Orthologs for SEC22C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC22C 35
  • 99.56 (n)
  • 99.67 (a)
SEC22C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC22C 35
  • 90.32 (n)
  • 92.08 (a)
SEC22C 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC22C 35
  • 91.2 (n)
  • 90.76 (a)
SEC22C 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec22c 35
  • 83.83 (n)
  • 81.52 (a)
Sec22c 16
Sec22c 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC22C 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC22C 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC687022 35
  • 74.64 (n)
  • 71.04 (a)
chicken
(Gallus gallus)
Aves SEC22C 35
  • 71.18 (n)
  • 67.33 (a)
SEC22C 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC22C 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22c 35
  • 61.36 (n)
  • 56.27 (a)
zebrafish
(Danio rerio)
Actinopterygii sec22c 35
  • 59.19 (n)
  • 49.83 (a)
sec22c 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sec22 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-22 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for SEC22C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22C Gene

ENSEMBL:
Gene Tree for SEC22C (if available)
TreeFam:
Gene Tree for SEC22C (if available)

Paralogs for SEC22C Gene

Paralogs for SEC22C Gene

Selected SIMAP similar genes for SEC22C Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SEC22C: view

Variants for SEC22C Gene

Sequence variations from dbSNP and Humsavar for SEC22C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs237064 -- 42,549,954(-) TGGCA(C/T)TCCCT intron-variant, utr-variant-3-prime
rs342534 -- 42,550,464(-) TCATC(C/T)GAGGG intron-variant, utr-variant-3-prime
rs342535 -- 42,550,646(-) GATAT(C/T)AGTTA intron-variant, utr-variant-3-prime
rs342536 -- 42,550,827(-) TTCCT(A/G)TGTGG intron-variant, utr-variant-3-prime
rs342537 -- 42,551,382(-) CCTGC(A/G)TGACA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEC22C Gene

Variant ID Type Subtype PubMed ID
esv2678489 CNV Deletion 23128226

Relevant External Links for SEC22C Gene

HapMap Linkage Disequilibrium report
SEC22C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC22C Gene

Disorders for SEC22C Gene

No disorders were found for SEC22C Gene.

No data available for UniProtKB/Swiss-Prot for SEC22C Gene

Publications for SEC22C Gene

  1. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  5. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3

Products for SEC22C Gene

Sources for SEC22C Gene

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