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Aliases for SEC22C Gene

Aliases for SEC22C Gene

  • SEC22 Homolog C, Vesicle Trafficking Protein 2 3 5
  • SEC22L3 3 4
  • SEC22 Vesicle Trafficking Protein Homolog C (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like 3 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like Protein C 3
  • SEC22 Vesicle Trafficking Protein Homolog C 3
  • SEC22 Vesicle-Trafficking Protein Homolog C 4
  • SEC22 Vesicle Trafficking Protein-Like 3 3
  • SEC22 Vesicle-Trafficking Protein-Like 3 4
  • Vesicle-Trafficking Protein SEC22c 3
  • Secretion Deficient 22C 3

External Ids for SEC22C Gene

Previous HGNC Symbols for SEC22C Gene

  • SEC22L3

Previous GeneCards Identifiers for SEC22C Gene

  • GC03M041894
  • GC03M042565

Summaries for SEC22C Gene

Entrez Gene Summary for SEC22C Gene

  • This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for SEC22C Gene

SEC22C (SEC22 Homolog C, Vesicle Trafficking Protein) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is SEC22A.

UniProtKB/Swiss-Prot for SEC22C Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

Additional gene information for SEC22C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22C Gene

Genomics for SEC22C Gene

Regulatory Elements for SEC22C Gene

Enhancers for SEC22C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H042650 1.6 FANTOM5 ENCODE dbSUPER 40.2 -52.7 -52749 6 HDGF PKNOX1 ATF1 ARNT ZFP64 SIN3A DMAP1 ZNF121 GLIS2 CBX5 SEC22C NKTR SS18L2 HHATL FAM198A ZBTB47 LOC101928323
GH03H042544 1.2 Ensembl ENCODE dbSUPER 50.9 +55.9 55922 1 ELF3 SOX13 GATAD2A CTCF FOXA2 NFIA FOXA3 REST NR3C1 NR2F2 SEC22C NKTR SS18L2 VIPR1 CCDC13 CCDC13-AS1 VIPR1-AS1
GH03H042599 1.4 Ensembl ENCODE 41.8 -0.1 -55 3 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 NKTR SEC22C SNRK-AS1 ZBTB47
GH03H042682 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.8 -84.1 -84059 4 FOXA2 ATF1 ARNT INSM2 EGR1 FOS CREM SMARCA5 ZNF362 CEBPB SEC22C HHATL LYZL4 NKTR CCDC13 CCK KRBOX1 KLHL40 RN7SL567P
GH03H042589 1 ENCODE 41.4 +10.1 10115 2 HDGF PKNOX1 ATF1 BRCA1 YY1 GTF3C2 GLIS2 ZNF143 ZNF207 FOS NKTR SEC22C CCDC13-AS1 CCDC13 SNRK-AS1 SS18L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC22C on UCSC Golden Path with GeneCards custom track

Promoters for SEC22C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151381 179 2600 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Transcription factor binding sites by QIAGEN in the SEC22C gene promoter:

Genomic Location for SEC22C Gene

Chromosome:
3
Start:
42,547,967 bp from pter
End:
42,601,080 bp from pter
Size:
53,114 bases
Orientation:
Minus strand

Genomic View for SEC22C Gene

Genes around SEC22C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22C Gene

Proteins for SEC22C Gene

  • Protein details for SEC22C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRL7-SC22C_HUMAN
    Recommended name:
    Vesicle-trafficking protein SEC22c
    Protein Accession:
    Q9BRL7
    Secondary Accessions:
    • O95152
    • Q68CX3
    • Q6UW18

    Protein attributes for SEC22C Gene

    Size:
    303 amino acids
    Molecular mass:
    34269 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEC22C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC22C Gene

Post-translational modifications for SEC22C Gene

  • Ubiquitination at Lys297
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC22C Gene

Domains & Families for SEC22C Gene

Gene Families for SEC22C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SEC22C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SEC22C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRL7

UniProtKB/Swiss-Prot:

SC22C_HUMAN :
  • Belongs to the synaptobrevin family.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22C: view

Function for SEC22C Gene

Molecular function for SEC22C Gene

UniProtKB/Swiss-Prot Function:
May be involved in vesicle transport between the ER and the Golgi complex.

Phenotypes From GWAS Catalog for SEC22C Gene

Gene Ontology (GO) - Molecular Function for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SEC22C: view
genes like me logo Genes that share phenotypes with SEC22C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SEC22C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC22C Gene

Localization for SEC22C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC22C gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9501016
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with SEC22C: view

Pathways & Interactions for SEC22C Gene

genes like me logo Genes that share pathways with SEC22C: view

Gene Ontology (GO) - Biological Process for SEC22C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 NOT exocytosis IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS 9501016
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SEC22C: view

No data available for SIGNOR curated interactions for SEC22C Gene

Drugs & Compounds for SEC22C Gene

No Compound Related Data Available

Transcripts for SEC22C Gene

Unigene Clusters for SEC22C Gene

SEC22 vesicle trafficking protein homolog C (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SEC22C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - - -
SP16:

ExUns: 13 ^ 14 ^ 15
SP1: -
SP2:
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for SEC22C Gene

GeneLoc Exon Structure for
SEC22C
ECgene alternative splicing isoforms for
SEC22C

Expression for SEC22C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC22C Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC22C Gene:

SEC22C

SOURCE GeneReport for Unigene cluster for SEC22C Gene:

Hs.445892

mRNA Expression by UniProt/SwissProt for SEC22C Gene:

Q9BRL7-SC22C_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SEC22C Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with SEC22C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC22C Gene

Orthologs for SEC22C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC22C 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia SEC22C 33 34
  • 91.2 (n)
cow
(Bos Taurus)
Mammalia SEC22C 33 34
  • 90.32 (n)
mouse
(Mus musculus)
Mammalia Sec22c 33 16 34
  • 83.83 (n)
rat
(Rattus norvegicus)
Mammalia LOC687022 33
  • 74.64 (n)
oppossum
(Monodelphis domestica)
Mammalia SEC22C 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC22C 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC22C 33 34
  • 71.18 (n)
lizard
(Anolis carolinensis)
Reptilia SEC22C 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22c 33
  • 61.36 (n)
zebrafish
(Danio rerio)
Actinopterygii sec22c 33 34
  • 59.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sec22 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-22 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for SEC22C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22C Gene

ENSEMBL:
Gene Tree for SEC22C (if available)
TreeFam:
Gene Tree for SEC22C (if available)

Paralogs for SEC22C Gene

Paralogs for SEC22C Gene

(1) SIMAP similar genes for SEC22C Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SEC22C: view

Variants for SEC22C Gene

Sequence variations from dbSNP and Humsavar for SEC22C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000031355 -- 42,587,536(+) ATCCT(A/G)GCTAA intron-variant
rs1000047793 -- 42,594,248(+) AGAAT(C/G)GGTGA intron-variant
rs1000079707 -- 42,570,638(+) TTGCA(A/G)CACCA intron-variant
rs1000115352 -- 42,589,997(+) CTGCC(C/G)GTATT intron-variant, utr-variant-5-prime
rs1000183047 -- 42,591,523(+) CTTTC(A/T)GCTCC intron-variant, splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC22C Gene

Variant ID Type Subtype PubMed ID
esv2678489 CNV deletion 23128226
esv3596001 CNV loss 21293372
esv3596002 CNV loss 21293372

Variation tolerance for SEC22C Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC22C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC22C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC22C Gene

Disorders for SEC22C Gene

Relevant External Links for SEC22C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC22C

No disorders were found for SEC22C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22C Gene

Publications for SEC22C Gene

  1. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang BL … Hong W (Biochemical and biophysical research communications 1998) 2 3 4 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The number of the C-terminal transmembrane domains has the potency to specify subcellular localization of Sec22c. (PMID: 28414125) Yamamoto Y … Sakisaka T (Biochemical and biophysical research communications 2017) 3 60
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 60

Products for SEC22C Gene

Sources for SEC22C Gene

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