SEC22B Gene
protein-coding GIFtS: 45
GCID: GC01P145096
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SEC22 vesicle trafficking protein homolog B (S. cerevisiae)...(Previous names: SEC22, vesicle trafficking protein (S. cerevisiae)-like...)
(Previous symbol: SEC22L1)
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Aliases
for SEC22B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae)(Gene/Pseudogene)1 2 | | SEC22, Vesicle Trafficking Protein (S. Cerevisiae)-Like 11 | | SEC22L11 2 3 5 | | Sec22b1 | | ERS-241 2 3 | | SEC22 Vesicle Trafficking Protein-Like 12 | | ER-Golgi SNARE Of 24 KDa2 3 | | Vesicle-Trafficking Protein SEC22b2 | | SEC22 Vesicle-Trafficking Protein Homolog B2 3 | | ERS243 | | SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae)1 | | SEC22 Vesicle-Trafficking Protein-Like 13 | | SEC22 Vesicle Trafficking Protein-Like 1 (S. Cerevisiae)1 | | |
Export aliases for SEC22B gene to outside databasesPrevious GC identifer: GC01P143807 |
Summaries
for SEC22B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEC22B:
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complexwith SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity toMus musculus and Cricetulus griseus proteins.(provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: SC22B_HUMAN, O75396Function: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well asGolgi-derived retrograde transport vesicles with the ER
Gene Wiki entry for SEC22B
|
Genomic Views
for SEC22B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:NC_018912.1 Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEC22B gene promoter:
TBP Pax-6 MEF-2A Ik-2 POU2F1 POU2F1a Cart-1 aMEF-2 ZID ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEC22B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC22B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1SEC22B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P145096: view genomic region
(about GC identifiers)
Start:
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145,096,220 bp from pter |
End:
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145,116,922 bp from pter |
Size:
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20,703 bases |
Orientation:
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plus strand |
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Proteins
for SEC22B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SC22B_HUMAN, O75396 (See
protein sequence)Recommended Name: Vesicle-trafficking protein SEC22b Size: 215 amino acids; 24593 Da
Subunit: Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L,BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membraneprotein (By similarity). Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Endoplasmicreticulum membrane; Single-pass type IV membrane protein (By similarity). Melanosome. Note=Identified by massspectrometry in melanosome fractions from stage I to stage IV
Caution: The reference genome displays a polymorphic premature stop codon in position 39
Sequence caution: Sequence=AL359758; Type=Erroneous termination; Positions=39; Note=Translated as Gln;
4 PDB 3D structures from  and Proteopedia  for SEC22B:2NUP (3D)
2NUT (3D)
3EGD (3D)
3EGX (3D)
Secondary accessions: A8K1G0Explore the universe of human proteins at neXtProt for SEC22B: NX_O75396
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75396
SEC22B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004883.3
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000139 | Golgi membrane |
IEA | -- | | GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
IDA | 15308636 | | GO:0016021 | integral to membrane |
IEA | -- | | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
IEA | -- |
SEC22B for ontologies About GeneDecksing
SEC22B Antibody Products:
Assay Products for SEC22B: |
Protein
Domains /
Families
for SEC22B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEC22B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75396ProtoNet protein and cluster: O75396 1 Blocks protein family: IPB001388 Synaptobrevin
UniProtKB/Swiss-Prot: SC22B_HUMAN, O75396Similarity: Belongs to the synaptobrevin familySimilarity: Contains 1 longin domainSimilarity: Contains 1 v-SNARE coiled-coil homology domain |
Function
for SEC22B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SC22B_HUMAN, O75396Function: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well asGolgi-derived retrograde transport vesicles with the ER
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC22B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC22B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: SEC22B (NM_004892) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC22B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC22B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC22B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SEC22B for ontologies About GeneDecksing
|
Pathways & Interactions
for SEC22B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | | | 2 | Phagosome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  PharmGKB Pathway for SEC22B
2 
Kegg Pathways (Kegg details for SEC22B):
SEC22B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC22B
5/140 Interacting proteins for SEC22B (O753963) via UniProtKB, MINT, STRING, and/or I2D (see all 140)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SEC22B for ontologies About GeneDecksing
|
Drugs & Compounds
for SEC22B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEC22B
Search CenterWatch for drugs/clinical trials and news about SEC22B / SC22B
|
Transcripts
for SEC22B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEC22B gene: NM_004892.5 Unigene Cluster for SEC22B: SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) Hs.632438 [show with all ESTs]Unigene Representative Sequence: NM_0048922 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000453618(lincRNA)(uc001eml.1) ENST00000500203(lincRNA)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC22B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC22B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SEC22B (NM_004892) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC22B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC22B |
Additional cDNA sequence: AF047442.1 AK289875.1 BC001364.2 XR_159107.1 16 DOTS entries: DT.115647 DT.100790831 DT.100683099 DT.100808467 DT.95333547 DT.121436036 DT.95333557 DT.95333563 DT.121435880 DT.121436003 DT.91725514 DT.92469472 DT.95333559 DT.121435423 DT.121435751 DT.86821317 24/200 AceView cDNA sequences (see all 200): CR595545 CR624978 BQ717920 AI493027 AI752847 BX438985 BI260001 AA234796 AI523459 AI085383 BE728614 CA443902 AA455917 AA456385 BE276993 BM807249 BX384476 BF897499 BV188340 BM874246 H25258 AI582119 AV731568 BI092644
GeneLoc Exon Structure
|
Expression
for SEC22B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEC22B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAACAAAGG
About this image
See SEC22B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC22B
SOURCE GeneReport for Unigene cluster: Hs.632438
SABiosciences Custom PCR Arrays for SEC22B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC22B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC22B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC22B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC22B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC22B |
Orthologs
for SEC22B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SEC22B gene from 3/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Sec22b5 |
SEC22 vesicle trafficking protein homolog B (S. cerevisiae) |
-- |
|
3 (42.35 cM) 97901190 |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC054298.12 |
-- |
85.15(n) |
|
BC054298.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
sec22l1b2 |
SEC22, vesicle trafficking protein (S. cerevisiae)-like more |
77.16(n) |
|
327277 BC055515.1 |
ENSEMBL Gene Tree for SEC22B (if available)
TreeFam Gene Tree for SEC22B (if available) |
Paralogs
for SEC22B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SEC22B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for SEC22B
15/16 CNVs (see all 16): 22945 97500 97499 97501 43738 5514 2324 23251 84515 23009 22602 84516 97502 34696 60885
1 Inversion: 103308 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SEC22B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SEC22B for disorders About MalaCards
SEC22B for disorders About GeneDecksing
OMIM gene information: 604029
OMIM disorders: --
Export disorders for SEC22B gene to outside databases
|
Publications
for SEC22B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEC22B gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with SEC22B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
- Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PubMed id 16354670)1, 3 Okumura A.J....Wada I. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 2 Nakajima K.... Tagaya M. (2004)
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (1998)
- Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. (PubMed id 9094723)1, 3 Hay J.C....Scheller R.H. (1997)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion. (PubMed id 22264512)1 Arasaki K....Roy C.R. (2012)
|
External Searches for SEC22B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SEC22B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SEC22B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SEC22B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SEC22B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SEC22B gene:
Search GeneIP for patents involving SEC22B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SEC22B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC22B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC22B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC22B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC22B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC22B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC22B |
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 |  |  |  | |
| | | | Search Tocris compounds for SEC22B |
| |  |  |  |  | | | | |
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 | | | SEC22B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC22B |
|  |  |  | | | | ThermoFisher Antibody for SEC22B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC22B |
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