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SEC22B Gene

protein-coding   GIFtS: 48
GCID: GC01P145096

SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae)...

(Previous names: SEC22, vesicle trafficking protein (S. cerevisiae)-like...)
(Previous symbol: SEC22L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae)
(Gene/Pseudogene)1 2
     SEC22 Vesicle Trafficking Protein-Like 1 (S. Cerevisiae)1
SEC22L11 2 3 5     SEC22, Vesicle Trafficking Protein (S. Cerevisiae)-Like 11
ERS-242 3     SEC22 Vesicle Trafficking Protein-Like 12
ER-Golgi SNARE Of 24 KDa2 3     Vesicle-Trafficking Protein SEC22b2
SEC22 Vesicle-Trafficking Protein Homolog B2 3     ERS243
SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae)1     SEC22 Vesicle-Trafficking Protein-Like 13

External Ids:    HGNC: 107001   Entrez Gene: 95542   Ensembl: ENSG000002233807   OMIM: 6040295   UniProtKB: O753963   

Export aliases for SEC22B gene to outside databases

Previous GC identifer: GC01P143807


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEC22B Gene:
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to
complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong
similarity to Mus musculus and Cricetulus griseus proteins.(provided by RefSeq, Sep 2009)

GeneCards Summary for SEC22B Gene:
SEC22B (SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)) is a protein-coding gene.

UniProtKB/Swiss-Prot: SC22B_HUMAN, O75396
Function: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well
as Golgi-derived retrograde transport vesicles with the ER

Gene Wiki entry for SEC22B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC22B gene promoter:
         TBP   Pax-6   MEF-2A   Ik-2   POU2F1   POU2F1a   Cart-1   aMEF-2   ZID   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC22B promoter sequence
   Search Chromatin IP Primers for SEC22B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC22B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

SEC22B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC22B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P145096:  view genomic region     (about GC identifiers)

Start:
145,096,220 bp from pter      End:
145,116,922 bp from pter
Size:
20,703 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SC22B_HUMAN, O75396 (See protein sequence)
Recommended Name: Vesicle-trafficking protein SEC22b  
Size: 215 amino acids; 24593 Da
Subunit: Interacts with STX17 (By similarity). Component of two distinct SNARE complexes consisting of STX5,
GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either
complex
Caution: The reference genome displays a polymorphic premature stop codon in position 39
Sequence caution: Sequence=AL359758; Type=Erroneous termination; Positions=39; Note=Translated as Gln;
4 PDB 3D structures from and Proteopedia for SEC22B:
2NUP (3D)        2NUT (3D)        3EGD (3D)        3EGX (3D)    
Secondary accessions: A8K1G0

Explore the universe of human proteins at neXtProt for SEC22B: NX_O75396

Explore proteomics data for SEC22B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38, Lys169
  • Modification sites at PhosphoSitePlus

  • See SEC22B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004883.3  

    SEC22B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SEC22B

     
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    antibodies-online proteins for SEC22B (9 products) 

     
    antibodies-online peptides for SEC22B

    SEC22B Antibody Products:

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    SEC22B Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010908 Longin_dom
     IPR011012 Longin-like_dom
     IPR001388 Synaptobrevin

    Graphical View of Domain Structure for InterPro Entry O75396

    ProtoNet protein and cluster: O75396

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: SC22B_HUMAN, O75396
    Similarity: Belongs to the synaptobrevin family
    Similarity: Contains 1 longin domain
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    Find genes that share domains with SEC22B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC22B_HUMAN, O75396
    Function: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well
    as Golgi-derived retrograde transport vesicles with the ER

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15272311
         
    Find genes that share ontologies with SEC22B           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sec22b):
     mortality/aging 

    Find genes that share phenotypes with SEC22B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC22B
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SEC22B (see all 27):
    hsa-miR-3910 hsa-miR-134 hsa-miR-374c hsa-miR-298 hsa-miR-924 hsa-miR-3118 hsa-miR-580 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidSEC22B 3' UTR sequence
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    Sino Biological Human cDNA Clone for SEC22B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC22B_HUMAN, O75396: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity).
    Endoplasmic reticulum-Golgi intermediate compartment membrane (By similarity). Golgi apparatus, cis-Golgi network
    membrane (By similarity). Golgi apparatus, trans-Golgi network membrane (By similarity). Melanosome.
    Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2.
    Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in
    melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA15308636
    GO:0005794Golgi apparatus IEA--
    GO:0016021integral component of membrane IEA--
    GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane IEA--

    Find genes that share ontologies with SEC22B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEC22B About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Phagosome
    Phagosome
    3Legionellosis
    Legionellosis


    Find genes that share SuperPaths with SEC22B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SEC22B
        Epithelial Tight Junctions


    1 PharmGKB Pathway for SEC22B
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    3 Kegg Pathways  (Kegg details for SEC22B):
        SNARE interactions in vesicular transport
    Phagosome
    Legionellosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC22B
    Interactions:

        Search GeneGlobe Interaction Network for SEC22B

    Selected Interacting proteins for SEC22B (O753963) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX5Q131903I2D: score=9 
    SAR1BQ9Y6B63I2D: score=4 
    SEC23AQ154363I2D: score=4 
    COG3Q96JB23I2D: score=3 
    GOSR1O952493I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006888ER to Golgi vesicle-mediated transport TAS9094723
    GO:0015031protein transport IEA--

    Find genes that share ontologies with SEC22B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC22B (SC22B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEC22B gene: 
    NM_004892.5  

    Unigene Cluster for SEC22B:

    SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
    Hs.632438  [show with all ESTs]
    Unigene Representative Sequence: NM_004892
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453618(processed_transcript) ENST00000500203(processed_transcript)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SEC22B (see all 27):
    hsa-miR-3910 hsa-miR-134 hsa-miR-374c hsa-miR-298 hsa-miR-924 hsa-miR-3118 hsa-miR-580 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidSEC22B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SEC22B (NM_004892)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC22B
    Primer
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    OriGene qPCR primer pairs and template standards for SEC22B
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC22B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC22B
      QuantiTect SYBR Green Assays in human, mouse, rat SEC22B
      QuantiFast Probe-based Assays in human, mouse, rat SEC22B

    Additional mRNA sequence: 

    AF047442.1 AK289875.1 BC001364.2 XR_159107.1 

    16 DOTS entries:

    DT.115647  DT.100790831  DT.100683099  DT.100808467  DT.95333547  DT.121436036  DT.95333557  DT.95333563 
    DT.121435880  DT.121436003  DT.91725514  DT.92469472  DT.95333559  DT.121435423  DT.121435751  DT.86821317 

    Selected AceView cDNA sequences (see all 200):

    CR595545 CR624978 AW959818 BX487780 BV188341 AA442691 BQ433298 AA234796 
    BU161394 AI160782 AI978980 BX339506 BM681993 BU508124 BI092644 BE275338 
    BM874246 AI582119 BV198003 AI674473 AV731568 AI902726 H25258 BG573124 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEC22B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACAAAGG
    SEC22B Expression
    About this image

    SEC22B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC22B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632438
        Custom PCR Arrays for SEC22B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC22B gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec22b1 , 5 SEC22 vesicle trafficking protein homolog B (S. cerevisiae)1, 5 93.02(n)1
    100(a)1
      3 (42.35 cM)5
    203331  NM_011342.41  NP_035472.11 
     979011905 
    chicken
    (Gallus gallus)
    Aves SEC22B1 SEC22 vesicle trafficking protein homolog B (S. cerevisiae) 83.26(n)
    98.14(a)
      424377  NM_001031266.2  NP_001026437.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054298.12   -- 85.15(n)    BC054298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sec22l1b2 SEC22, vesicle trafficking protein (S. cerevisiae)-like more 77.16(n)   327277  BC055515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sec221 Sec22 57.66(n)
    57.82(a)
      31030  NM_001272174.1  NP_001259103.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sec-221 sec-22 52.07(n)
    50.25(a)
      180456  NM_075797.4  NP_508198.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC221 SEC22 51.05(n)
    40.58(a)
      850973   NP_013370.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SEC221 SEC22 54.11(n)
    49.28(a)
      837737  NM_101060.3  NP_172653.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07915001 Os03g0791500 53.23(n)
    45.16(a)
      4334384  NM_001058055.2  NP_001051520.2 


    ENSEMBL Gene Tree for SEC22B (if available)
    TreeFam Gene Tree for SEC22B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEC22B gene
    1 SIMAP similar gene for SEC22B using alignment to 6 protein entries:     SC22B_HUMAN (see all proteins):
    SEC22A

    Find genes that share paralogs with SEC22B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    6 SNPs for SEC22B    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25963311,2,4
    ----see VAR_0603112 mis40--------
    rs75344441,2,4
    ----see VAR_0573442 mis40--------
    rs25901311,2,4
    ----see VAR_0603132 mis40--------
    rs26555571,2,4
    ----see VAR_0603142 mis40--------
    rs27940531,2,4
    ----see VAR_0603122 mis40--------
    rs26555511,2,4
    ----see VAR_0573432 mis40--------

    HapMap Linkage Disequilibrium report for SEC22B (145096220 - 145116922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SEC22B (see all 40):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv18n16CNV Deletion17901297
    esv2548575CNV Deletion19546169
    dgv66e199CNV Deletion23128226
    dgv46e201CNV Deletion23290073
    esv2717363CNV Deletion23290073
    dgv7e180CNV Deletion20482838
    dgv17n16CNV Deletion17901297
    esv2717206CNV Deletion23290073
    dgv15n16CNV Deletion17901297
    esv2229660CNV Deletion18987734

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SEC22B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604029    OMIM disorders: --


    Find genes that share disorders with SEC22B           About GenesLikeMe


    Export disorders for SEC22B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEC22B gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with SEC22B)
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    1. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    2. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PubMed id 16354670)1, 3 Okumura A.J....Wada I. (J. Biol. Chem. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 2 Nakajima K.... Tagaya M. (EMBO J. 2004)
    5. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    6. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. (PubMed id 9094723)1, 3 Hay J.C....Scheller R.H. (Cell 1997)
    7. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    8. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9554 HGNC: 10700 AceView: SEC22L1 Ensembl:ENSG00000223380 euGenes: HUgn9554
    ECgene: SEC22B Kegg: 9554 H-InvDB: SEC22B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEC22B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEC22B gene:
    Search GeneIP for patents involving SEC22B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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