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Aliases for SEC22B Gene

Aliases for SEC22B Gene

  • SEC22 Homolog B, Vesicle Trafficking Protein (Gene/Pseudogene) 2 3 5
  • SEC22 Vesicle-Trafficking Protein Homolog B 3 4
  • ER-Golgi SNARE Of 24 KDa 3 4
  • SEC22L1 3 4
  • ERS-24 3 4
  • SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) (Gene/Pseudogene) 2
  • SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) 2
  • SEC22, Vesicle Trafficking Protein (S. Cerevisiae)-Like 1 2
  • SEC22 Vesicle Trafficking Protein-Like 1 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein Homolog B 3
  • SEC22 Vesicle Trafficking Protein-Like 1 3
  • SEC22 Vesicle-Trafficking Protein-Like 1 4
  • ERS24 4

External Ids for SEC22B Gene

Previous HGNC Symbols for SEC22B Gene

  • SEC22L1

Previous GeneCards Identifiers for SEC22B Gene

  • GC01P143807
  • GC01P145096

Summaries for SEC22B Gene

Entrez Gene Summary for SEC22B Gene

  • The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]

GeneCards Summary for SEC22B Gene

SEC22B (SEC22 Homolog B, Vesicle Trafficking Protein (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Phagosome. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is SEC22C.

UniProtKB/Swiss-Prot for SEC22B Gene

  • SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Gene Wiki entry for SEC22B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22B Gene

Genomics for SEC22B Gene

Regulatory Elements for SEC22B Gene

Enhancers for SEC22B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEC22B on UCSC Golden Path with GeneCards custom track

Promoters for SEC22B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC22B on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC22B Gene

Chromosome:
1
Start:
120,150,898 bp from pter
End:
120,176,521 bp from pter
Size:
25,624 bases
Orientation:
Minus strand

Genomic View for SEC22B Gene

Genes around SEC22B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22B Gene

Proteins for SEC22B Gene

  • Protein details for SEC22B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75396-SC22B_HUMAN
    Recommended name:
    Vesicle-trafficking protein SEC22b
    Protein Accession:
    O75396
    Secondary Accessions:
    • A8K1G0

    Protein attributes for SEC22B Gene

    Size:
    215 amino acids
    Molecular mass:
    24593 Da
    Quaternary structure:
    • Interacts with STX17 (By similarity). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex.
    SequenceCaution:
    • Sequence=AL359758; Type=Erroneous termination; Positions=39; Note=Translated as Gln.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC22B Gene

neXtProt entry for SEC22B Gene

Proteomics data for SEC22B Gene at MOPED

Post-translational modifications for SEC22B Gene

  • Ubiquitination at Lys 169
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC22B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC22B Gene

Domains & Families for SEC22B Gene

Gene Families for SEC22B Gene

Protein Domains for SEC22B Gene

Suggested Antigen Peptide Sequences for SEC22B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75396

UniProtKB/Swiss-Prot:

SC22B_HUMAN :
  • Contains 1 longin domain.
  • Belongs to the synaptobrevin family.
Domain:
  • Contains 1 longin domain.
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22B: view

Function for SEC22B Gene

Molecular function for SEC22B Gene

UniProtKB/Swiss-Prot Function:
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Gene Ontology (GO) - Molecular Function for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with SEC22B: view

Phenotypes for SEC22B Gene

MGI mutant phenotypes for SEC22B:
inferred from 1 alleles
GenomeRNAi human phenotypes for SEC22B:
genes like me logo Genes that share phenotypes with SEC22B: view

Animal Models for SEC22B Gene

MGI Knock Outs for SEC22B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SEC22B Gene

Localization for SEC22B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22B Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Gene Ontology (GO) - Cellular Components for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS --
genes like me logo Genes that share ontologies with SEC22B: view

No data available for Subcellular locations from COMPARTMENTS for SEC22B Gene

Pathways & Interactions for SEC22B Gene

genes like me logo Genes that share pathways with SEC22B: view

Interacting Proteins for SEC22B Gene

Gene Ontology (GO) - Biological Process for SEC22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 NOT exocytosis IBA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0033043 regulation of organelle organization IMP 21242315
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SEC22B: view

No data available for SIGNOR curated interactions for SEC22B Gene

Drugs & Compounds for SEC22B Gene

No Compound Related Data Available

Transcripts for SEC22B Gene

mRNA/cDNA for SEC22B Gene

Unigene Clusters for SEC22B Gene

SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22B Gene

No ASD Table

Relevant External Links for SEC22B Gene

GeneLoc Exon Structure for
SEC22B
ECgene alternative splicing isoforms for
SEC22B

Expression for SEC22B Gene

mRNA expression in normal human tissues for SEC22B Gene

Protein differential expression in normal tissues from HIPED for SEC22B Gene

This gene is overexpressed in Bone (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SEC22B Gene



SOURCE GeneReport for Unigene cluster for SEC22B Gene Hs.632438

genes like me logo Genes that share expression patterns with SEC22B: view

Protein tissue co-expression partners for SEC22B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC22B Gene

Orthologs for SEC22B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC22B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC614775 35
  • 93.05 (n)
  • 98.58 (a)
dog
(Canis familiaris)
Mammalia LOC475816 35
  • 94.42 (n)
  • 99.53 (a)
mouse
(Mus musculus)
Mammalia Sec22b 35
  • 93.02 (n)
  • 100 (a)
Sec22b 16
rat
(Rattus norvegicus)
Mammalia Sec22b 35
  • 91.63 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SEC22B 35
  • 83.26 (n)
  • 98.14 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22b 35
  • 80 (n)
  • 93.02 (a)
Sec22l1-prov 35
zebrafish
(Danio rerio)
Actinopterygii LOC100535340 35
  • 76.59 (n)
  • 90.23 (a)
sec22l1b 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9851 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012717 35
  • 60.61 (n)
  • 58.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sec22 35
  • 57.66 (n)
  • 57.82 (a)
worm
(Caenorhabditis elegans)
Secernentea sec-22 35
  • 52.07 (n)
  • 50.25 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR267W 35
  • 51.46 (n)
  • 42.72 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20251g 35
  • 48.31 (n)
  • 39.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 35
  • 51.05 (n)
  • 40.58 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC22 35
  • 54.11 (n)
  • 49.28 (a)
rice
(Oryza sativa)
Liliopsida Os03g0791500 35
  • 53.23 (n)
  • 45.16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12748 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06708 35
  • 46.93 (n)
  • 39.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec22 35
  • 48.8 (n)
  • 42.11 (a)
Species with no ortholog for SEC22B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22B Gene

ENSEMBL:
Gene Tree for SEC22B (if available)
TreeFam:
Gene Tree for SEC22B (if available)

Paralogs for SEC22B Gene

Paralogs for SEC22B Gene

(1) SIMAP similar genes for SEC22B Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SEC22B Gene

genes like me logo Genes that share paralogs with SEC22B: view

Variants for SEC22B Gene

Sequence variations from dbSNP and Humsavar for SEC22B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_057343 -
VAR_057344 -
VAR_060311 -
VAR_060312 -
VAR_060313 -

Structural Variations from Database of Genomic Variants (DGV) for SEC22B Gene

Variant ID Type Subtype PubMed ID
nsv428212 CNV Gain 18775914
nsv872203 CNV Gain 21882294
dgv103e1 CNV Complex 17122850
dgv104e1 CNV Complex 17122850
nsv7181 OTHER Inversion 18451855
nsv436028 CNV Insertion 17901297
esv2717206 CNV Deletion 23290073
dgv66e199 CNV Deletion 23128226
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
nsv510962 CNV Complex 20534489
nsv509457 CNV Insertion 20534489
nsv872214 CNV Gain 21882294
dgv105e1 CNV Complex 17122850
dgv106e1 CNV Complex 17122850
dgv107e1 CNV Complex 17122850
dgv108e1 CNV Complex 17122850
dgv110e1 CNV Complex 17122850
dgv344n71 CNV Gain 21882294
nsv2644 CNV Loss 18451855
nsv872222 CNV Gain 21882294
dgv17n16 CNV Deletion 17901297
dgv111e1 CNV Complex 17122850
esv2593580 CNV Gain 19546169
dgv18n16 CNV Deletion 17901297
esv2548575 CNV Deletion 19546169
esv2229660 CNV Deletion 18987734
dgv7e180 CNV Deletion 20482838
nsv511713 CNV Loss 21212237
esv2717351 CNV Deletion 23290073
esv5594 CNV Loss 19470904
nsv161167 CNV Loss 16902084
esv2460355 OTHER Inversion 19546169
esv268838 CNV Insertion 20981092
esv274269 CNV Insertion 20981092
esv2581967 CNV Gain 19546169
essv1329 CNV CNV 17122850
essv18481 CNV CNV 17122850
esv2717363 CNV Deletion 23290073
esv2509949 CNV Deletion 19546169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for SEC22B Gene

Disorders for SEC22B Gene

Relevant External Links for SEC22B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC22B

No disorders were found for SEC22B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22B Gene

Publications for SEC22B Gene

  1. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4 67
  2. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PMID: 16354670) Okumura A.J. … Wada I. (J. Biol. Chem. 2006) 2 3
  3. Morphological and functional association of Sec22b/ERS-24 with the pre-Golgi intermediate compartment. (PMID: 9950687) Zhang T. … Hong W. (Mol. Biol. Cell 1999) 2 3
  4. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. (PMID: 9094723) Hay J.C. … Scheller R.H. (Cell 1997) 2 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for SEC22B Gene

Sources for SEC22B Gene

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