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Aliases for SEC22A Gene

Aliases for SEC22A Gene

  • SEC22 Homolog A, Vesicle Trafficking Protein 2 3 5
  • SEC22 Vesicle-Trafficking Protein Homolog A 3 4
  • SEC22 Vesicle-Trafficking Protein-Like 2 3 4
  • SEC22L2 3 4
  • SEC22 Vesicle Trafficking Protein Homolog A (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like 2 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein Homolog A 3
  • SEC22 Vesicle Trafficking Protein-Like 2 3
  • Sec22 Homolog 3

External Ids for SEC22A Gene

Previous HGNC Symbols for SEC22A Gene

  • SEC22L2

Previous GeneCards Identifiers for SEC22A Gene

  • GC03P119643
  • GC03P124404
  • GC03P122920
  • GC03P120295

Summaries for SEC22A Gene

Entrez Gene Summary for SEC22A Gene

  • The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]

GeneCards Summary for SEC22A Gene

SEC22A (SEC22 Homolog A, Vesicle Trafficking Protein) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include transporter activity and SNAP receptor activity. An important paralog of this gene is SEC22C.

UniProtKB/Swiss-Prot for SEC22A Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

Gene Wiki entry for SEC22A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22A Gene

Genomics for SEC22A Gene

Regulatory Elements for SEC22A Gene

Enhancers for SEC22A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEC22A on UCSC Golden Path with GeneCards custom track

Promoters for SEC22A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC22A on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC22A Gene

123,201,927 bp from pter
123,274,136 bp from pter
72,210 bases
Plus strand

Genomic View for SEC22A Gene

Genes around SEC22A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22A Gene

Proteins for SEC22A Gene

  • Protein details for SEC22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle-trafficking protein SEC22a
    Protein Accession:
    Secondary Accessions:
    • B2RE26
    • Q9Y682

    Protein attributes for SEC22A Gene

    307 amino acids
    Molecular mass:
    34948 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD43013.1; Type=Frameshift; Positions=265, 288; Evidence={ECO:0000305};

neXtProt entry for SEC22A Gene

Proteomics data for SEC22A Gene at MOPED

Post-translational modifications for SEC22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC22A Gene

Domains & Families for SEC22A Gene

Gene Families for SEC22A Gene

Protein Domains for SEC22A Gene


Suggested Antigen Peptide Sequences for SEC22A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 longin domain.
  • Belongs to the synaptobrevin family.
  • Contains 1 longin domain.
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22A: view

Function for SEC22A Gene

Molecular function for SEC22A Gene

UniProtKB/Swiss-Prot Function:
May be involved in vesicle transport between the ER and the Golgi complex.

Gene Ontology (GO) - Molecular Function for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
genes like me logo Genes that share ontologies with SEC22A: view

Phenotypes for SEC22A Gene

genes like me logo Genes that share phenotypes with SEC22A: view

Animal Model Products

miRNA for SEC22A Gene

miRTarBase miRNAs that target SEC22A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC22A Gene

Localization for SEC22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SEC22A Gene COMPARTMENTS Subcellular localization image for SEC22A gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for SEC22A Gene

Pathways & Interactions for SEC22A Gene

genes like me logo Genes that share pathways with SEC22A: view

Gene Ontology (GO) - Biological Process for SEC22A Gene


No data available for SIGNOR curated interactions for SEC22A Gene

Drugs & Compounds for SEC22A Gene

No Compound Related Data Available

Transcripts for SEC22A Gene

Unigene Clusters for SEC22A Gene

SEC22 vesicle trafficking protein homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP8: - -
SP9: -
SP10: -

Relevant External Links for SEC22A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC22A Gene

mRNA expression in normal human tissues for SEC22A Gene

Protein differential expression in normal tissues from HIPED for SEC22A Gene

This gene is overexpressed in Islet of Langerhans (21.1) and Testis (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC22A Gene

SOURCE GeneReport for Unigene cluster for SEC22A Gene Hs.477361

genes like me logo Genes that share expression patterns with SEC22A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SEC22A Gene

Orthologs for SEC22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEC22A 35
  • 95.55 (n)
  • 96.09 (a)
SEC22A 36
  • 87 (a)
(Canis familiaris)
Mammalia SEC22A 35
  • 95.11 (n)
  • 95.77 (a)
SEC22A 36
  • 78 (a)
(Mus musculus)
Mammalia Sec22a 35
  • 93.38 (n)
  • 96.74 (a)
Sec22a 16
Sec22a 36
  • 97 (a)
(Pan troglodytes)
Mammalia SEC22A 35
  • 99.89 (n)
  • 100 (a)
SEC22A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sec22a 35
  • 92.73 (n)
  • 95.11 (a)
(Monodelphis domestica)
Mammalia SEC22A 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SEC22A 36
  • 56 (a)
(Gallus gallus)
Aves SEC22A 35
  • 81.22 (n)
  • 86.64 (a)
SEC22A 36
  • 86 (a)
(Anolis carolinensis)
Reptilia SEC22A 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22l2 35
  • 66.45 (n)
  • 70.53 (a)
Str.10293 35
(Danio rerio)
Actinopterygii -- 35
sec22a 35
  • 68.21 (n)
  • 70.63 (a)
sec22a 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sec22 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea sec-22 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 36
  • 25 (a)
SEC22 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for SEC22A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22A Gene

Gene Tree for SEC22A (if available)
Gene Tree for SEC22A (if available)

Paralogs for SEC22A Gene

Paralogs for SEC22A Gene

(2) SIMAP similar genes for SEC22A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SEC22A: view

Variants for SEC22A Gene

Sequence variations from dbSNP and Humsavar for SEC22A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1877970 -- 123,203,033(-) TGATG(G/T)TTTTA intron-variant, upstream-variant-2KB
rs1877971 -- 123,203,028(-) GTTTT(A/C)AACAT intron-variant, upstream-variant-2KB
rs2332472 -- 123,210,209(-) cactt(C/T)ctcct intron-variant
rs1969261 -- 123,245,200(-) ATTTT(A/T)AAGTA intron-variant
rs4432576 -- 123,203,054(+) GTGCC(C/T)TTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEC22A Gene

Variant ID Type Subtype PubMed ID
nsv877394 CNV Gain 21882294
nsv524614 CNV Loss 19592680
dgv297n21 CNV Loss 19592680
esv275521 CNV Gain+Loss 21479260
nsv3976 CNV Insertion 18451855
nsv877395 CNV Gain 21882294

Variation tolerance for SEC22A Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SEC22A Gene

Disorders for SEC22A Gene

Relevant External Links for SEC22A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC22A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22A Gene

Publications for SEC22A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1998) 2 3
  3. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. (PMID: 9094723) Hay J.C. … Scheller R.H. (Cell 1997) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SEC22A Gene

Sources for SEC22A Gene