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Aliases for SEC22A Gene

Aliases for SEC22A Gene

  • SEC22 Vesicle Trafficking Protein Homolog A (S. Cerevisiae) 2 3
  • SEC22L2 3 4 6
  • SEC22 Vesicle-Trafficking Protein Homolog A 3 4
  • SEC22 Vesicle-Trafficking Protein-Like 2 3 4
  • SEC22 Vesicle Trafficking Protein-Like 2 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like 2 3
  • Vesicle-Trafficking Protein SEC22a 3
  • Sec22 Homolog 3

External Ids for SEC22A Gene

Previous HGNC Symbols for SEC22A Gene

  • SEC22L2

Previous GeneCards Identifiers for SEC22A Gene

  • GC03P119643
  • GC03P124404
  • GC03P122920
  • GC03P120295

Summaries for SEC22A Gene

Entrez Gene Summary for SEC22A Gene

  • The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]

GeneCards Summary for SEC22A Gene

SEC22A (SEC22 Vesicle Trafficking Protein Homolog A (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include transporter activity. An important paralog of this gene is SEC22C.

UniProtKB/Swiss-Prot for SEC22A Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

Gene Wiki entry for SEC22A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22A Gene

Genomics for SEC22A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC22A Gene

Start:
123,201,927 bp from pter
End:
123,274,136 bp from pter
Size:
72,210 bases
Orientation:
Plus strand

Genomic View for SEC22A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22A Gene

Proteins for SEC22A Gene

  • Protein details for SEC22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IW7-SC22A_HUMAN
    Recommended name:
    Vesicle-trafficking protein SEC22a
    Protein Accession:
    Q96IW7
    Secondary Accessions:
    • B2RE26
    • Q9Y682

    Protein attributes for SEC22A Gene

    Size:
    307 amino acids
    Molecular mass:
    34948 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD43013.1; Type=Frameshift; Positions=265, 288; Evidence={ECO:0000305};

neXtProt entry for SEC22A Gene

Proteomics data for SEC22A Gene at MOPED

Post-translational modifications for SEC22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC22A Gene

Domains for SEC22A Gene

Protein Domains for SEC22A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SEC22A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IW7

UniProtKB/Swiss-Prot:

SC22A_HUMAN :
  • Q96IW7
Domain:
  • Contains 1 longin domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22A: view

No data available for Gene Families for SEC22A Gene

Function for SEC22A Gene

Molecular function for SEC22A Gene

UniProtKB/Swiss-Prot Function: May be involved in vesicle transport between the ER and the Golgi complex.

Gene Ontology (GO) - Molecular Function for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005215 transporter activity TAS 8621431
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SEC22A: view

Animal Model Products

CRISPR Products

miRNA for SEC22A Gene

miRTarBase miRNAs that target SEC22A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC22A Gene

Localization for SEC22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC22A Gene COMPARTMENTS Subcellular localization image for SEC22A gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with SEC22A: view

Pathways for SEC22A Gene

genes like me logo Genes that share pathways with SEC22A: view

Pathways by source for SEC22A Gene

Gene Ontology (GO) - Biological Process for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006887 NOT exocytosis IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0015031 protein transport IEA --
GO:0048280 vesicle fusion with Golgi apparatus IBA --
genes like me logo Genes that share ontologies with SEC22A: view

Transcripts for SEC22A Gene

Unigene Clusters for SEC22A Gene

SEC22 vesicle trafficking protein homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC22A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP7:
SP8: - -
SP9: -
SP10: -

Relevant External Links for SEC22A Gene

GeneLoc Exon Structure for
SEC22A
ECgene alternative splicing isoforms for
SEC22A

Expression for SEC22A Gene

mRNA expression in normal human tissues for SEC22A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC22A Gene

SOURCE GeneReport for Unigene cluster for SEC22A Gene Hs.477361

genes like me logo Genes that share expressions with SEC22A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC22A Gene

Orthologs for SEC22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC22A 35
  • 99.89 (n)
  • 100 (a)
SEC22A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC22A 35
  • 95.55 (n)
  • 96.09 (a)
SEC22A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC22A 35
  • 95.11 (n)
  • 95.77 (a)
SEC22A 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec22a 35
  • 93.38 (n)
  • 96.74 (a)
Sec22a 16
Sec22a 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC22A 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC22A 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec22a 35
  • 92.73 (n)
  • 95.11 (a)
chicken
(Gallus gallus)
Aves SEC22A 35
  • 81.22 (n)
  • 86.64 (a)
SEC22A 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC22A 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22l2 35
  • 66.45 (n)
  • 70.53 (a)
Str.10293 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
sec22a 35
  • 68.21 (n)
  • 70.63 (a)
sec22a 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sec22 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-22 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 36
  • 25 (a)
OneToMany
SEC22 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for SEC22A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22A Gene

ENSEMBL:
Gene Tree for SEC22A (if available)
TreeFam:
Gene Tree for SEC22A (if available)

Paralogs for SEC22A Gene

Paralogs for SEC22A Gene

Selected SIMAP similar genes for SEC22A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SEC22A: view

Variants for SEC22A Gene

Sequence variations from dbSNP and Humsavar for SEC22A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1204 -- 123,272,388(-) ATTTC(A/G)AAAGA utr-variant-3-prime
rs1944 -- 123,271,887(-) GGACT(C/T)TTCCA utr-variant-3-prime
rs15662 -- 123,271,994(-) GCCAA(G/T)ACTTC utr-variant-3-prime
rs16335 -- 123,271,888(+) GAAGA(-/CCTGCTAGGAAAA)GTCCT utr-variant-3-prime
rs950972 -- 123,255,855(-) AACTT(C/T)TCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC22A Gene

Variant ID Type Subtype PubMed ID
nsv877394 CNV Gain 21882294
nsv524614 CNV Loss 19592680
dgv297n21 CNV Loss 19592680
esv275521 CNV Gain+Loss 21479260
nsv3976 CNV Insertion 18451855
nsv877395 CNV Gain 21882294

Relevant External Links for SEC22A Gene

HapMap Linkage Disequilibrium report
SEC22A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC22A Gene

Disorders for SEC22A Gene

Relevant External Links for SEC22A

Genetic Association Database (GAD)
SEC22A
Human Genome Epidemiology (HuGE) Navigator
SEC22A
genes like me logo Genes that share disorders with SEC22A: view

No data available for UniProtKB/Swiss-Prot for SEC22A Gene

Publications for SEC22A Gene

  1. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. (PMID: 9094723) Hay J.C. … Scheller R.H. (Cell 1997) 2 3
  2. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1998) 2 3
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SEC22A Gene

Sources for SEC22A Gene

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