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Aliases for SEC22A Gene

Aliases for SEC22A Gene

  • SEC22 Homolog A, Vesicle Trafficking Protein 2 3 5
  • SEC22L2 3 4
  • SEC22 Vesicle Trafficking Protein Homolog A (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein-Like 2 (S. Cerevisiae) 2
  • SEC22 Vesicle Trafficking Protein Homolog A 3
  • SEC22 Vesicle-Trafficking Protein Homolog A 4
  • SEC22 Vesicle Trafficking Protein-Like 2 3
  • SEC22 Vesicle-Trafficking Protein-Like 2 4
  • Vesicle-Trafficking Protein SEC22a 3

External Ids for SEC22A Gene

Previous HGNC Symbols for SEC22A Gene

  • SEC22L2

Previous GeneCards Identifiers for SEC22A Gene

  • GC03P119643
  • GC03P124404
  • GC03P122920
  • GC03P120295

Summaries for SEC22A Gene

Entrez Gene Summary for SEC22A Gene

  • The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]

GeneCards Summary for SEC22A Gene

SEC22A (SEC22 Homolog A, Vesicle Trafficking Protein) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transporter activity and SNAP receptor activity. An important paralog of this gene is SEC22C.

UniProtKB/Swiss-Prot for SEC22A Gene

  • May be involved in vesicle transport between the ER and the Golgi complex.

Gene Wiki entry for SEC22A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC22A Gene

Genomics for SEC22A Gene

Regulatory Elements for SEC22A Gene

Enhancers for SEC22A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G122645 1.3 Ensembl ENCODE 33.5 -555.2 -555210 1.5 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 FOS JUNB SEC22A ENSG00000273454 PARP14 LOC102723582 EIF4BP8 PIR41127
GH03G123272 1 Ensembl ENCODE 40.6 +71.4 71370 1.6 NFIB JUN ZFHX2 POLR2A NFE2 MAFK NFE2L2 EGR2 NFIA MNT SEC22A ENSG00000273454
GH03G123200 1 ENCODE 30.6 +0.0 41 2.1 PKNOX1 ATF1 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 SEC22A ENSG00000273454
GH03G123426 1 dbSUPER 29.9 +229.2 229228 9.4 HDGF PKNOX1 FOXA2 ZFP64 FEZF1 YBX1 ZNF2 ZNF121 KLF7 TSHZ1 SEC22A MYLK-AS1 ENSG00000273454 ADCY5 GC03P123375
GH03G123341 1.1 dbSUPER 21.5 +146.3 146312 13.6 PKNOX1 FOXA2 CREB3L1 MLX ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 SEC22A LOC102723582 ADCY5 PARP9 DTX3L PIR43483 GC03P123375
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC22A on UCSC Golden Path with GeneCards custom track

Promoters for SEC22A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157425 173 1401 PKNOX1 ATF1 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1

Genomic Location for SEC22A Gene

123,201,927 bp from pter
123,274,136 bp from pter
72,210 bases
Plus strand

Genomic View for SEC22A Gene

Genes around SEC22A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC22A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC22A Gene

Proteins for SEC22A Gene

  • Protein details for SEC22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle-trafficking protein SEC22a
    Protein Accession:
    Secondary Accessions:
    • B2RE26
    • Q9Y682

    Protein attributes for SEC22A Gene

    307 amino acids
    Molecular mass:
    34948 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD43013.1; Type=Frameshift; Positions=265, 288; Evidence={ECO:0000305};

neXtProt entry for SEC22A Gene

Post-translational modifications for SEC22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC22A Gene

Domains & Families for SEC22A Gene

Gene Families for SEC22A Gene

Protein Domains for SEC22A Gene

Suggested Antigen Peptide Sequences for SEC22A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptobrevin family.
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with SEC22A: view

Function for SEC22A Gene

Molecular function for SEC22A Gene

UniProtKB/Swiss-Prot Function:
May be involved in vesicle transport between the ER and the Golgi complex.

Gene Ontology (GO) - Molecular Function for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005215 transporter activity TAS 8621431
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SEC22A: view

Phenotypes for SEC22A Gene

genes like me logo Genes that share phenotypes with SEC22A: view

Animal Model Products

CRISPR Products

miRNA for SEC22A Gene

miRTarBase miRNAs that target SEC22A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC22A Gene

Localization for SEC22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC22A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC22A gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with SEC22A: view

Pathways & Interactions for SEC22A Gene

genes like me logo Genes that share pathways with SEC22A: view

Gene Ontology (GO) - Biological Process for SEC22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 NOT exocytosis IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS,IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SEC22A: view

No data available for SIGNOR curated interactions for SEC22A Gene

Drugs & Compounds for SEC22A Gene

No Compound Related Data Available

Transcripts for SEC22A Gene

Unigene Clusters for SEC22A Gene

SEC22 vesicle trafficking protein homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC22A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP8: - -
SP9: -
SP10: -

Relevant External Links for SEC22A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC22A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC22A Gene

Protein differential expression in normal tissues from HIPED for SEC22A Gene

This gene is overexpressed in Islet of Langerhans (21.1) and Testis (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC22A Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC22A Gene:


SOURCE GeneReport for Unigene cluster for SEC22A Gene:


Evidence on tissue expression from TISSUES for SEC22A Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with SEC22A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC22A Gene

Orthologs for SEC22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC22A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC22A 34 35
  • 99.89 (n)
(Bos Taurus)
Mammalia SEC22A 34 35
  • 95.55 (n)
(Canis familiaris)
Mammalia SEC22A 34 35
  • 95.11 (n)
(Mus musculus)
Mammalia Sec22a 34 16 35
  • 93.38 (n)
(Rattus norvegicus)
Mammalia Sec22a 34
  • 92.73 (n)
(Monodelphis domestica)
Mammalia SEC22A 35
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SEC22A 35
  • 56 (a)
(Gallus gallus)
Aves SEC22A 34 35
  • 81.22 (n)
(Anolis carolinensis)
Reptilia SEC22A 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec22l2 34
  • 66.45 (n)
Str.10293 34
(Danio rerio)
Actinopterygii sec22a 34 35
  • 68.21 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Sec22 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea sec-22 35
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC22 35 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
Species where no ortholog for SEC22A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC22A Gene

Gene Tree for SEC22A (if available)
Gene Tree for SEC22A (if available)

Paralogs for SEC22A Gene

Paralogs for SEC22A Gene

(2) SIMAP similar genes for SEC22A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SEC22A: view

Variants for SEC22A Gene

Sequence variations from dbSNP and Humsavar for SEC22A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000079850 -- 123,219,489(+) ATCCT(A/G)TCTTT intron-variant
rs1000109860 -- 123,235,473(+) AATTA(C/G)AAGTA intron-variant
rs1000131704 -- 123,248,321(+) TTTCT(A/G)TGTAG intron-variant
rs1000167391 -- 123,223,278(+) TATAT(C/T)CATTC intron-variant
rs1000212545 -- 123,237,272(+) GGTAA(A/G)AGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC22A Gene

Variant ID Type Subtype PubMed ID
dgv297n21 CNV loss 19592680
esv275521 CNV gain+loss 21479260
nsv1003681 CNV gain 25217958
nsv1013747 CNV loss 25217958
nsv1127990 CNV deletion 24896259
nsv3976 CNV insertion 18451855
nsv524614 CNV loss 19592680

Variation tolerance for SEC22A Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC22A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC22A Gene

Disorders for SEC22A Gene

Relevant External Links for SEC22A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC22A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC22A Gene

Publications for SEC22A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  5. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. (PMID: 9501016) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1998) 2 3 64

Products for SEC22A Gene

Sources for SEC22A Gene

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