Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEC16B Gene

protein-coding   GIFtS: 53
GCID: GC01M177896

SEC16 Homolog B (S. Cerevisiae)

(Previous name: leucine zipper transcription regulator 2)
(Previous symbol: LZTR2)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SEC16 Homolog B (S. Cerevisiae)1 2     RGPR-p1172 3
LZTR21 2 3 5     PGPR-p1172
Leucine Zipper Transcription Regulator 21 2 3     Protein SEC16 Homolog B2
RGPR2 3 5     Protein Transport Protein Sec16B2
SEC16S2 3 5     KIAA19283
Regucalcin Gene Promotor Region Related Protein1 2     SEC16 Homolog B3
Regucalcin Gene Promoter Region-Related Protein P1172 3     

External Ids:    HGNC: 303011   Entrez Gene: 898662   Ensembl: ENSG000001203417   OMIM: 6128555   UniProtKB: Q96JE73   

Export aliases for SEC16B gene to outside databases

Previous GC identifers: GC01M176166 GC01M149125


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEC16B Gene:
SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic
reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 (PubMed 17192411)).(supplied by OMIM, Jun
2009)

GeneCards Summary for SEC16B Gene:
SEC16B (SEC16 homolog B (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is SEC16A.

UniProtKB/Swiss-Prot: SC16B_HUMAN, Q96JE7
Function: Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for
normal transitional endoplasmic reticulum (tER) organization

Gene Wiki entry for SEC16B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC16B gene promoter:
         TBP   HFH-3   STAT5B   Pbx1a   POU3F1   Brachyury   FOXI1   CREB   deltaCREB   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC16B promoter sequence
   Search Chromatin IP Primers for SEC16B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC16B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

SEC16B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC16B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M177896:  view genomic region     (about GC identifiers)

Start:
177,893,091 bp from pter      End:
177,953,438 bp from pter
Size:
60,348 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SC16B_HUMAN, Q96JE7 (See protein sequence)
Recommended Name: Protein transport protein Sec16B  
Size: 1060 amino acids; 116604 Da
Subunit: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex
Secondary accessions: A3EYF1 Q5HYF6 Q8N7D6 Q96GX6
Alternative splicing: 3 isoforms:  Q96JE7-1   Q96JE7-2   Q96JE7-3   

Explore the universe of human proteins at neXtProt for SEC16B: NX_Q96JE7

Explore proteomics data for SEC16B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SEC16B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149118.2  
    ENSEMBL proteins: 
     ENSP00000308339   ENSP00000475522   ENSP00000431727   ENSP00000435101  

    SEC16B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SEC16B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEC16B
    GenScript Custom Purified and Recombinant Proteins Services for SEC16B
    Novus Biologicals SEC16B Proteins
    Novus Biologicals SEC16B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SEC16B 

    SEC16B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SEC16B
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SEC16B
    OriGene Custom Antibody Services for SEC16B
    Novus Biologicals SEC16B Antibodies
    Abcam antibodies for SEC16B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SEC16B
    LSBio Antibodies in human, mouse, rat for SEC16B

    SEC16B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEC16B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEC16B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SEC16B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR024880 Sec16
     IPR024340 Sec16_CCD

    Graphical View of Domain Structure for InterPro Entry Q96JE7

    ProtoNet protein and cluster: Q96JE7

    1 Blocks protein domain: IPB006162 Phosphopantetheine attachment site

    UniProtKB/Swiss-Prot: SC16B_HUMAN, Q96JE7
    Similarity: Belongs to the SEC16 family


    Find genes that share domains with SEC16B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC16B_HUMAN, Q96JE7
    Function: Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for
    normal transitional endoplasmic reticulum (tER) organization

    Phenotypes:
         2 GenomeRNAi human phenotypes for SEC16B:

     Increased G1 DNA content  Increased circadian period len 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sec16b):
     homeostasis/metabolism 

    Find genes that share phenotypes with SEC16B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC16B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC16B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC16B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC16B

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC16B:
    hsa-mir-335-5p (MIRT017884)

    Block miRNA regulation of human, mouse, rat SEC16B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEC16B (see all 18):
    hsa-miR-199b-3p hsa-miR-539 hsa-miR-24-1* hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-24-2* hsa-miR-1244 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidSEC16B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEC16B
    Predesigned siRNA for gene silencing in human, mouse, rat SEC16B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC16B

    Clone
    Products:
         
    OriGene clones in human, mouse for SEC16B (see all 9)
    OriGene ORF clones in mouse, rat for SEC16B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC16B (NM_033127)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC16B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC16B
    Addgene plasmids for SEC16B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEC16B
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEC16B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC16B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SC16B_HUMAN, Q96JE7: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Golgi apparatus
    membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with SEC16B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC16B
    Interactions:

        Search GeneGlobe Interaction Network for SEC16B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC16B (Q96JE73 ENSP000003083394) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEC13P557353, ENSP000003121224I2D: score=3 STRING: ENSP00000312122
    PSMF1Q925303I2D: score=1 
    USO1ENSP000004116984STRING: ENSP00000411698
    SEC31AENSP000003473294STRING: ENSP00000347329
    SEC31BENSP000003593704STRING: ENSP00000359370
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007029endoplasmic reticulum organization IDA--
    GO:0007031peroxisome organization IDA--
    GO:0010628positive regulation of gene expression IMP--
    GO:0015031protein transport IEA--
    GO:0016559peroxisome fission IMP--

    Find genes that share ontologies with SEC16B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC16B (SC16B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEC16B gene: 
    NM_033127.2  

    Unigene Cluster for SEC16B:

    SEC16 homolog B (S. cerevisiae)
    Hs.149540  [show with all ESTs]
    Unigene Representative Sequence: NM_033127
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441371 ENST00000495165 ENST00000308284 ENST00000327037 ENST00000528461
    ENST00000526773 ENST00000464631(uc001gll.4) ENST00000527976
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEC16B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEC16B (see all 18):
    hsa-miR-199b-3p hsa-miR-539 hsa-miR-24-1* hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-24-2* hsa-miR-1244 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidSEC16B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEC16B
    Predesigned siRNA for gene silencing in human, mouse, rat SEC16B
    Clone
    Products:
         
    OriGene clones in human, mouse for SEC16B (see all 9)
    OriGene ORF clones in mouse, rat for SEC16B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC16B (NM_033127)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC16B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC16B
    Addgene plasmids for SEC16B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEC16B
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC16B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC16B
      QuantiTect SYBR Green Assays in human, mouse, rat SEC16B
      QuantiFast Probe-based Assays in human, mouse, rat SEC16B

    Additional mRNA sequence: 

    AB063357.1 AK074451.1 AK090971.1 AK093939.1 AK098627.1 AK314585.1 BC009106.1 BC108267.1 
    EF125213.1 

    8 DOTS entries:

    DT.95180203  DT.95267557  DT.100781524  DT.100023126  DT.121327632  DT.70103139  DT.95267560  DT.100652491 

    Selected AceView cDNA sequences (see all 131):

    AX748374 AA336017 BX509240 AK098627 AA235344 BM471388 AI925437 BX509870 
    AI431750 AK093939 BP370620 BM127583 AA460256 AI950524 AI804404 AA235749 
    BM717557 AI553689 AW778810 AV647413 AI128692 AW137403 BI550762 AA100264 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEC16B (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
    SP1:                                -     -     -     -     -     -           -     -     -     -                                                     -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                  -         
    SP5:                                                        -                                                                                                   

    ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b · 39c · 39d ^ 40
    SP1:                          -                 -                                                                                                   
    SP2:                          -                 -                                                                                                   
    SP3:                                            -                                                     -                                             
    SP4:                          -                                                                                                                     
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for SEC16B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEC16B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTGGCAC
    SEC16B Expression
    About this image


    SEC16B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Bone (Muscoskeletal System)
             Rib
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Liver (Hepatobiliary System)
    SEC16B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC16B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149540

    UniProtKB/Swiss-Prot: SC16B_HUMAN, Q96JE7
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for SEC16B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEC16B
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC16B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC16B
    QuantiTect SYBR Green Assays in human, mouse, rat SEC16B
    QuantiFast Probe-based Assays in human, mouse, rat SEC16B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC16B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SEC16B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec16b1 , 5 SEC16 homolog B (S. cerevisiae)1, 5 79.93(n)1
    74.21(a)1
      1 (68.00 cM)5
    898671  NM_001159986.11  NP_001153458.11 
     1575067285 
    chicken
    (Gallus gallus)
    Aves SEC16B1 SEC16 homolog B (S. cerevisiae) 61.08(n)
    56(a)
      424431  NM_001031269.1  NP_001026440.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC16B6
    SEC16 homolog B (S. cerevisiae)
    66(a)
    1 ↔ 1
    GL343300.1(57305-116059)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sec16b1 SEC16 homolog B (S. cerevisiae) 54.57(n)
    48.18(a)
      100488357  XM_004914026.1  XP_004914083.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SEC16B6
    SEC16 homolog B (S. cerevisiae)
    33(a)
    1 ↔ 1
    6(20034682-20074894) ENSDARG00000052046
    fruit fly
    (Drosophila melanogaster)
    Insecta Sec166
    Sec16
    10(a)
    1 → many
    X(12490080-12503943)
    worm
    (Caenorhabditis elegans)
    Secernentea sec-166
    F13B9.16
    Protein SEC-16 (sec-16) mRNA, complete cds
    Protein F13B9.1, isoform a (F13B9.1) mRNA, complet...
    15(a)
    11(a)
    many ↔ many
    many ↔ many
    III(9125839-9130810) WBGene00013985
    X(8287261-8294515) WBGene00017419


    ENSEMBL Gene Tree for SEC16B (if available)
    TreeFam Gene Tree for SEC16B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEC16B gene
    SEC16A2  
    2 SIMAP similar genes for SEC16B using alignment to 4 protein entries:     SC16B_HUMAN (see all proteins):
    FLJ00305    KIAA1928

    Find genes that share paralogs with SEC16B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEC16B (see all 1091)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878488611,2
    --177897796(+) ATTCCC/TCATTA 1 -- ds50010--------
    rs168521531,2
    C,F,H--177897850(+) AACCAT/CTATTA 1 -- ds500110Minor allele frequency- C:0.05NA NS EA 996
    rs1895892401,2
    --177897896(+) CTTCCC/TCTGTA 1 -- ds50010--------
    rs82231,2
    C,F,A,H--177897959(+) ATCAAC/TATCAG 1 -- ds500129Minor allele frequency- T:0.38MN NA NS EA WA CSA 2661
    rs80301,2
    C,F,A,H--177897975(+) TAGAAC/TATTAA 1 -- ds5001 ese335Minor allele frequency- T:0.36MN NA EA NS WA CSA 3575
    rs1822069481,2
    --177897982(+) TTAACA/GTACTA 1 -- ds50010--------
    rs1880459061,2
    --177897993(+) AACCTA/GTATTT 1 -- ds50010--------
    rs1926681741,2
    --177897994(+) ACCTGA/TATTTA 1 -- ds50010--------
    rs120274261,2
    C,H--177898116(+) AAGACG/ACCCCC 1 -- ds5001 ese34Minor allele frequency- A:0.00NS EA 416
    rs1487412381,2
    --177898352(+) GCCACA/GTGCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SEC16B (177893091 - 177953438 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SEC16B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719829CNV Deletion23290073
    esv2663986CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC16B
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC16B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612855    OMIM disorders: --


    Find genes that share disorders with SEC16B           About GenesLikeMe

    Genetic Association Database (GAD): SEC16B
    Human Genome Epidemiology (HuGE) Navigator: SEC16B (15 documents)

    Export disorders for SEC16B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEC16B gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with SEC16B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. (PubMed id 11605020)1, 2, 3, 9 Misawa H. and Yamaguchi M. (Int. J. Mol. Med. 2001)
    2. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. (PubMed id 20724581)1, 4 den Hoed M....Loos R.J. (Diabetes 2010)
    3. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. (PubMed id 19812171)1, 4 Li S....Loos R.J. (Am. J. Clin. Nutr. 2010)
    4. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PubMed id 20215397)1, 4 Ng M.C....Ma R.C. (J. Clin. Endocrinol. Metab. 2010)
    5. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    6. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    7. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (PubMed id 20712903)1, 4 Morgan A.R....Mitchell E.A. (BMC Med. Genet. 2010)
    8. Evaluation of genetic susceptibility loci for obesity in Chinese women. (PubMed id 20616199)1, 4 Shi J....Shu X.O. (Am. J. Epidemiol. 2010)
    9. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PubMed id 19851340)1, 4 Hotta K....Nakamura Y. (J. Hum. Genet. 2009)
    10. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PubMed id 19079260)1, 4 Thorleifsson G....Stefansson K. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 89866 HGNC: 30301 AceView: RGPR Ensembl:ENSG00000120341 euGenes: HUgn89866
    ECgene: SEC16B H-InvDB: SEC16B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1928

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEC16B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEC16B gene:
    Search GeneIP for patents involving SEC16B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SEC16B
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SEC16B   OriGene RNAi products in human, mouse, rat for SEC16B  
     OriGene qPCR primer pairs and template standards for SEC16B   OriGene Protein Over-expression Lysate for SEC16B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SEC16B  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEC16B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SEC16B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEC16B   OriGene Custom Protein Services for SEC16B  

     
     
     Block miRNA regulation of human, mouse, rat SEC16B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEC16B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC16B Predesigned siRNA for gene silencing in human, mouse, rat SEC16B
     QuantiFast Probe-based Assays in human, mouse, rat SEC16B QuantiTect SYBR Green Assays in human, mouse, rat SEC16B
     Custom PCR Arrays for SEC16B Search Chromatin IP Primers for SEC16B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC16B  Search GeneGlobe Interaction Network for SEC16B
     Regulatory tfbs in SEC16B promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEC16B GenScript cDNA clones with any tag delivered in your preferred vector for SEC16B
     GenScript Custom Assay Services for SEC16B GenScript Custom overexpressing Cell Line Services for SEC16B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEC16B (SC16B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEC16B antibodies
     SEC16B proteins
     SEC16B lysates
     Antibodies for SEC16B
     See all of Abcam's Antibodies, Kits and Proteins for SEC16B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEC16B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC16B
     SwitchGear 3'UTR luciferase reporter plasmids for SEC16B
     SwitchGear Promoter luciferase reporter plasmids for SEC16B
     ThermoFisher Antibodies for SEC16B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC16B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC16B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC16B
     LSBio Antibodies in human, mouse, rat for SEC16B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for SEC16B
      Search eBioscience for proteins for SEC16B
      Search eBioscience for elisas for SEC16B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEC16B gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4