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Aliases for SEC16B Gene

Aliases for SEC16B Gene

  • SEC16 Homolog B, Endoplasmic Reticulum Export Factor 2 3 5
  • Leucine Zipper Transcription Regulator 2 2 3 4
  • Regucalcin Gene Promoter Region-Related Protein P117 3 4
  • Regucalcin Gene Promotor Region Related Protein 2 3
  • SEC16 Homolog B 3 4
  • RGPR-P117 3 4
  • SEC16S 3 4
  • LZTR2 3 4
  • RGPR 3 4
  • SEC16 Homolog B (S. Cerevisiae) 2
  • Protein SEC16 Homolog B 3
  • PGPR-P117 3
  • KIAA1928 4

External Ids for SEC16B Gene

Previous HGNC Symbols for SEC16B Gene

  • LZTR2

Previous GeneCards Identifiers for SEC16B Gene

  • GC01M176166
  • GC01M177896
  • GC01M149125

Summaries for SEC16B Gene

Entrez Gene Summary for SEC16B Gene

  • SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SEC16B Gene

SEC16B (SEC16 Homolog B, Endoplasmic Reticulum Export Factor) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. An important paralog of this gene is SEC16A.

UniProtKB/Swiss-Prot for SEC16B Gene

  • Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization.

Gene Wiki entry for SEC16B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC16B Gene

Genomics for SEC16B Gene

Regulatory Elements for SEC16B Gene

Promoters for SEC16B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEC16B on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC16B Gene

Chromosome:
1
Start:
177,923,956 bp from pter
End:
177,984,303 bp from pter
Size:
60,348 bases
Orientation:
Minus strand

Genomic View for SEC16B Gene

Genes around SEC16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC16B Gene

Proteins for SEC16B Gene

  • Protein details for SEC16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JE7-SC16B_HUMAN
    Recommended name:
    Protein transport protein Sec16B
    Protein Accession:
    Q96JE7
    Secondary Accessions:
    • A3EYF1
    • Q5HYF6
    • Q8N7D6
    • Q96GX6

    Protein attributes for SEC16B Gene

    Size:
    1060 amino acids
    Molecular mass:
    116604 Da
    Quaternary structure:
    • SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

    Alternative splice isoforms for SEC16B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC16B Gene

Proteomics data for SEC16B Gene at MOPED

Post-translational modifications for SEC16B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC16B Gene

Antibody Products

No data available for DME Specific Peptides for SEC16B Gene

Domains & Families for SEC16B Gene

Protein Domains for SEC16B Gene

Graphical View of Domain Structure for InterPro Entry

Q96JE7

UniProtKB/Swiss-Prot:

SC16B_HUMAN :
  • Belongs to the SEC16 family.
Family:
  • Belongs to the SEC16 family.
genes like me logo Genes that share domains with SEC16B: view

No data available for Gene Families for SEC16B Gene

Function for SEC16B Gene

Molecular function for SEC16B Gene

UniProtKB/Swiss-Prot Function:
Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization.
genes like me logo Genes that share phenotypes with SEC16B: view

Animal Models for SEC16B Gene

MGI Knock Outs for SEC16B:

Animal Model Products

miRNA for SEC16B Gene

miRTarBase miRNAs that target SEC16B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEC16B Gene

Localization for SEC16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC16B Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC16B Gene COMPARTMENTS Subcellular localization image for SEC16B gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
golgi apparatus 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SEC16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SEC16B: view

Pathways & Interactions for SEC16B Gene

genes like me logo Genes that share pathways with SEC16B: view

Interacting Proteins for SEC16B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308339%0d%0a9606.ENSP00000312122%0d%0a
Selected Interacting proteins: Q96JE7-SC16B_HUMAN ENSP00000308339 for SEC16B Gene via UniProtKB I2D STRING

SIGNOR curated interactions for SEC16B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SEC16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007031 peroxisome organization IDA 21768384
GO:0015031 protein transport IEA --
GO:0016559 peroxisome fission IMP 21768384
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SEC16B: view

Drugs & Compounds for SEC16B Gene

No Compound Related Data Available

Transcripts for SEC16B Gene

Unigene Clusters for SEC16B Gene

SEC16 homolog B (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC16B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - - - - - - - - - -
SP2: -
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - - -
SP8: - - - - - - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b · 39c · 39d ^ 40
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SEC16B Gene

GeneLoc Exon Structure for
SEC16B
ECgene alternative splicing isoforms for
SEC16B

Expression for SEC16B Gene

mRNA expression in normal human tissues for SEC16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEC16B Gene

This gene is overexpressed in Liver (x14.1).

Protein differential expression in normal tissues from HIPED for SEC16B Gene

This gene is overexpressed in Liver (42.3), Fetal Liver (16.4), and Pancreas (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEC16B Gene



SOURCE GeneReport for Unigene cluster for SEC16B Gene Hs.149540

mRNA Expression by UniProt/SwissProt for SEC16B Gene

Q96JE7-SC16B_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SEC16B: view

Protein tissue co-expression partners for SEC16B Gene

Primer Products

In Situ Assay Products

Orthologs for SEC16B Gene

This gene was present in the common ancestor of animals.

Orthologs for SEC16B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC16B 35
  • 83.48 (n)
  • 77.61 (a)
SEC16B 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC16B 35
  • 82.98 (n)
  • 77.31 (a)
SEC16B 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec16b 35
  • 79.93 (n)
  • 74.21 (a)
Sec16b 16
Sec16b 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC16B 35
  • 97.79 (n)
  • 96.55 (a)
rat
(Rattus norvegicus)
Mammalia Sec16b 35
  • 79.58 (n)
  • 72.61 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC16B 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC16B 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC16B 35
  • 61.08 (n)
  • 56 (a)
SEC16B 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC16B 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec16b 35
  • 54.57 (n)
  • 48.18 (a)
zebrafish
(Danio rerio)
Actinopterygii SEC16B 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sec16 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13B9.1 36
  • 11 (a)
ManyToMany
sec-16 36
  • 15 (a)
ManyToMany
Species with no ortholog for SEC16B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC16B Gene

ENSEMBL:
Gene Tree for SEC16B (if available)
TreeFam:
Gene Tree for SEC16B (if available)

Paralogs for SEC16B Gene

Paralogs for SEC16B Gene

(2) SIMAP similar genes for SEC16B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SEC16B: view

Variants for SEC16B Gene

Sequence variations from dbSNP and Humsavar for SEC16B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12040910 - 177,960,852(+) CTACA(C/T)GCACC reference, missense
rs943762 - 177,939,717(+) TCCTC(C/T)GGCTC reference, missense
rs7522194 - 177,936,334(+) GGAGG(A/C)TGGGA reference, missense
rs591120 - 177,933,618(+) TCGTG(A/C/G)TCTAG reference, missense
rs3813649 - 177,933,590(-) CGCCA(A/C/G/T)TTCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SEC16B Gene

Variant ID Type Subtype PubMed ID
esv2719829 CNV Deletion 23290073
esv2663986 CNV Deletion 23128226

Variation tolerance for SEC16B Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.53; 95.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC16B Gene

HapMap Linkage Disequilibrium report
SEC16B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC16B Gene

Disorders for SEC16B Gene

Relevant External Links for SEC16B

Genetic Association Database (GAD)
SEC16B
Human Genome Epidemiology (HuGE) Navigator
SEC16B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC16B

No disorders were found for SEC16B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC16B Gene

Publications for SEC16B Gene

  1. Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. (PMID: 11605020) Misawa H. … Yamaguchi M. (Int. J. Mol. Med. 2001) 2 3 4 23 67
  2. Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells. (PMID: 21768384) Yonekawa S. … Tani K. (Proc. Natl. Acad. Sci. U.S.A. 2011) 2 3
  3. Novel protein RGPR-p117: its role as the regucalcin gene transcription factor. (PMID: 19214710) Yamaguchi M. (Mol. Cell. Biochem. 2009) 3 23
  4. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization. (PMID: 17192411) Bhattacharyya D. … Glick B.S. (Mol. Biol. Cell 2007) 2 3
  5. Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population. (PMID: 25637721) Lv D. … Zhu Y.M. (Gene 2015) 3

Products for SEC16B Gene

Sources for SEC16B Gene

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