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Aliases for SEC16A Gene

Aliases for SEC16A Gene

  • SEC16 Homolog A (S. Cerevisiae) 2 3
  • KIAA0310 2 3 4 6
  • SEC16L 3 4 6
  • P250 3 6
  • Protein Transport Protein Sec16A 3
  • Protein SEC16 Homolog A 3
  • SEC16 Homolog A 4
  • SEC16 4

External Ids for SEC16A Gene

Previous HGNC Symbols for SEC16A Gene

  • KIAA0310

Previous GeneCards Identifiers for SEC16A Gene

  • GC09M138455
  • GC09M139334
  • GC09M108793

Summaries for SEC16A Gene

Entrez Gene Summary for SEC16A Gene

  • This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]

GeneCards Summary for SEC16A Gene

SEC16A (SEC16 Homolog A (S. Cerevisiae)) is a Protein Coding gene. An important paralog of this gene is SEC16B.

UniProtKB/Swiss-Prot for SEC16A Gene

  • Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization.

Gene Wiki entry for SEC16A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC16A Gene

Genomics for SEC16A Gene

Regulatory Elements for SEC16A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC16A Gene

Start:
136,440,096 bp from pter
End:
136,484,840 bp from pter
Size:
44,745 bases
Orientation:
Minus strand

Genomic View for SEC16A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC16A Gene

Proteins for SEC16A Gene

  • Protein details for SEC16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15027-SC16A_HUMAN
    Recommended name:
    Protein transport protein Sec16A
    Protein Accession:
    O15027
    Secondary Accessions:
    • A1YCA4
    • Q4G0D7
    • Q5SXP0
    • Q5SXP1
    • Q8N347
    • Q96HP1

    Protein attributes for SEC16A Gene

    Size:
    2179 amino acids
    Molecular mass:
    233517 Da
    Quaternary structure:
    • SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with SEC23A.
    SequenceCaution:
    • Sequence=BAA20769.4; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13949.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13951.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SEC16A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC16A Gene

Proteomics data for SEC16A Gene at MOPED

Post-translational modifications for SEC16A Gene

No data available for DME Specific Peptides for SEC16A Gene

Domains for SEC16A Gene

Protein Domains for SEC16A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15027

UniProtKB/Swiss-Prot:

SC16A_HUMAN :
  • O15027
Family:
  • Belongs to the SEC16 family.
genes like me logo Genes that share domains with SEC16A: view

No data available for Gene Families for SEC16A Gene

Function for SEC16A Gene

Molecular function for SEC16A Gene

UniProtKB/Swiss-Prot Function: Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization.

Gene Ontology (GO) - Molecular Function for SEC16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25201882
genes like me logo Genes that share ontologies with SEC16A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC16A Gene

Localization for SEC16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC16A Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC16A Gene COMPARTMENTS Subcellular localization image for SEC16A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 3

Gene Ontology (GO) - Cellular Components for SEC16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with SEC16A: view

Pathways for SEC16A Gene

SuperPathways for SEC16A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEC16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007029 endoplasmic reticulum organization IDA 21768384
GO:0015031 protein transport IEA --
GO:0021762 substantia nigra development IEP 22926577
GO:0048208 COPII vesicle coating IEA --
genes like me logo Genes that share ontologies with SEC16A: view

No data available for Pathways by source for SEC16A Gene

Compounds for SEC16A Gene

(1) HMDB Compounds for SEC16A Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with SEC16A: view

Transcripts for SEC16A Gene

Unigene Clusters for SEC16A Gene

SEC16 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC16A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEC16A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC16A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - - - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b · 29c · 29d ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34a · 34b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - - - -
SP13: -
SP14: - - - - - -
SP15: - - -
SP16: -
SP17: -
SP18:
SP19:

ExUns: 34c · 34d · 34e · 34f · 34g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for SEC16A Gene

GeneLoc Exon Structure for
SEC16A
ECgene alternative splicing isoforms for
SEC16A

Expression for SEC16A Gene

mRNA expression in normal human tissues for SEC16A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC16A Gene

SOURCE GeneReport for Unigene cluster for SEC16A Gene Hs.522500

mRNA Expression by UniProt/SwissProt for SEC16A Gene

O15027-SC16A_HUMAN
Tissue specificity: Ubiquitous. Expressed at higher levels in the pancreas.
genes like me logo Genes that share expressions with SEC16A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SEC16A Gene

Orthologs for SEC16A Gene

This gene was present in the common ancestor of animals.

Orthologs for SEC16A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC16A 35
  • 98.02 (n)
  • 97.32 (a)
cow
(Bos Taurus)
Mammalia SEC16A 35
  • 74.34 (n)
  • 69.67 (a)
SEC16A 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC16A 35
  • 77.45 (n)
  • 72.37 (a)
SEC16A 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec16a 35
  • 76.08 (n)
  • 71.25 (a)
Sec16a 16
Sec16a 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC16A 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC16A 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec16a 35
  • 75.73 (n)
  • 71.3 (a)
chicken
(Gallus gallus)
Aves SEC16A 35
  • 61.94 (n)
  • 56.5 (a)
SEC16A 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC16A 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec16a 35
  • 52.42 (n)
  • 40.46 (a)
Str.20474 35
zebrafish
(Danio rerio)
Actinopterygii LOC567075 35
  • 52.98 (n)
  • 49.28 (a)
SEC16A 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sec16 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13B9.1 36
  • 15 (a)
ManyToMany
sec-16 36
  • 17 (a)
ManyToMany
Species with no ortholog for SEC16A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC16A Gene

ENSEMBL:
Gene Tree for SEC16A (if available)
TreeFam:
Gene Tree for SEC16A (if available)

Paralogs for SEC16A Gene

Paralogs for SEC16A Gene

Selected SIMAP similar genes for SEC16A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SEC16A: view

Variants for SEC16A Gene

Sequence variations from dbSNP and Humsavar for SEC16A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3124590 -- 136,465,902(+) ATGCC(A/G)GGCTG intron-variant
rs3124615 -- 136,443,450(+) gaagc(C/T)gaggt intron-variant
rs3124996 -- 136,443,286(+) CACGG(C/T)GGGCC intron-variant
rs3124997 -- 136,449,267(+) GTTTT(C/T)TGAGA intron-variant
rs3812591 -- 136,447,160(+) ACTCA(C/T)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC16A Gene

Variant ID Type Subtype PubMed ID
nsv825173 CNV Gain 20364138
nsv894294 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
dgv8386n71 CNV Loss 21882294
dgv8390n71 CNV Loss 21882294
dgv8392n71 CNV Loss 21882294
nsv509333 CNV Insertion 20534489
nsv482928 CNV Loss 15286789
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
dgv8394n71 CNV Loss 21882294
nsv831760 CNV Loss 17160897
nsv894365 CNV Loss 21882294
nsv894367 CNV Loss 21882294
nsv6766 CNV Insertion 18451855
dgv8395n71 CNV Loss 21882294
dgv8396n71 CNV Loss 21882294
dgv8397n71 CNV Gain 21882294
nsv894373 CNV Loss 21882294
nsv894376 CNV Gain+Loss 21882294
esv30005 CNV Loss 17803354
nsv894377 CNV Loss 21882294
dgv8398n71 CNV Gain 21882294
nsv894379 CNV Gain+Loss 21882294
dgv8399n71 CNV Loss 21882294
dgv8400n71 CNV Loss 21882294
nsv894386 CNV Loss 21882294
nsv894387 CNV Gain 21882294

Relevant External Links for SEC16A Gene

HapMap Linkage Disequilibrium report
SEC16A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC16A Gene

Disorders for SEC16A Gene

No disorders were found for SEC16A Gene.

No data available for UniProtKB/Swiss-Prot for SEC16A Gene

Publications for SEC16A Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for SEC16A Gene

Sources for SEC16A Gene

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