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Aliases for SEC14L6 Gene

Aliases for SEC14L6 Gene

  • SEC14 Like Lipid Binding 6 2 3 5
  • SEC14-Like 6 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 6 2
  • SEC14-Like 6 2

External Ids for SEC14L6 Gene

Previous GeneCards Identifiers for SEC14L6 Gene

  • GC22M030921

Summaries for SEC14L6 Gene

GeneCards Summary for SEC14L6 Gene

SEC14L6 (SEC14 Like Lipid Binding 6) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SEC14L4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L6 Gene

Genomics for SEC14L6 Gene

Regulatory Elements for SEC14L6 Gene

Enhancers for SEC14L6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G030415 1.4 ENCODE dbSUPER 7.8 +125.3 125278 11.6 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RNF215 TUG1 SEC14L3 CASTOR1 MORC2 SEC14L2 CCDC157 SEC14L6 SMTN RNU6-564P
GH22G030705 0.9 ENCODE 10.3 -159.6 -159602 1.7 PKNOX1 FOXA2 WRNIP1 ARID4B ZNF48 GLIS2 FOS TBX21 MIER3 SMARCA4 OSBP2 DUSP18 GAL3ST1 SEC14L6 ENSG00000249590 SEC14L2 MIR3200
GH22G030605 1.4 FANTOM5 ENCODE 6.6 -61.4 -61354 5.5 PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF766 ZNF143 FOS ZNF263 SP5 TCN2 OSM SLC35E4 ENSG00000250318 SEC14L6 SMTN DUSP18 TBC1D10A CCDC157 SF3A1
GH22G029820 1.6 Ensembl ENCODE dbSUPER 4.6 +725.0 724961 2.4 FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ASCC2 MGC20647 SEC14L6 UQCR10
GH22G030355 1.1 ENCODE 6.5 +190.3 190313 2.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 RNF215 CASTOR1 CCDC157 SEC14L6 TBC1D10A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC14L6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC14L6 Gene

30,522,799 bp from pter
30,546,717 bp from pter
23,919 bases
Minus strand

Genomic View for SEC14L6 Gene

Genes around SEC14L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L6 Gene

Proteins for SEC14L6 Gene

  • Protein details for SEC14L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative SEC14-like protein 6
    Protein Accession:

    Protein attributes for SEC14L6 Gene

    397 amino acids
    Molecular mass:
    45364 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEC14L6 Gene

Post-translational modifications for SEC14L6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC14L6 Gene

Domains & Families for SEC14L6 Gene

Gene Families for SEC14L6 Gene

Protein Domains for SEC14L6 Gene

Suggested Antigen Peptide Sequences for SEC14L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SEC14L6: view

No data available for UniProtKB/Swiss-Prot for SEC14L6 Gene

Function for SEC14L6 Gene

Gene Ontology (GO) - Molecular Function for SEC14L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SEC14L6: view

Phenotypes for SEC14L6 Gene

GenomeRNAi human phenotypes for SEC14L6:
genes like me logo Genes that share phenotypes with SEC14L6: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L6 Gene

Localization for SEC14L6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L6 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SEC14L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC14L6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEC14L6 Gene

Pathways & Interactions for SEC14L6 Gene

SuperPathways for SEC14L6 Gene

No Data Available

Interacting Proteins for SEC14L6 Gene

Gene Ontology (GO) - Biological Process for SEC14L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SEC14L6: view

No data available for Pathways by source and SIGNOR curated interactions for SEC14L6 Gene

Drugs & Compounds for SEC14L6 Gene

No Compound Related Data Available

Transcripts for SEC14L6 Gene

mRNA/cDNA for SEC14L6 Gene

(8) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEC14L6 Gene

SEC14-like 6 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L6 Gene

No ASD Table

Relevant External Links for SEC14L6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC14L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC14L6 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L6 Gene

This gene is overexpressed in Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for SEC14L6 Gene

This gene is overexpressed in Adipocyte (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEC14L6 Gene

Protein tissue co-expression partners for SEC14L6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC14L6 Gene:


SOURCE GeneReport for Unigene cluster for SEC14L6 Gene:

genes like me logo Genes that share expression patterns with SEC14L6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC14L6 Gene

Orthologs for SEC14L6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC14L6 34 35
  • 98.24 (n)
(Bos Taurus)
Mammalia SEC14L6 34
  • 85.23 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
(Gallus gallus)
Aves -- 35
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
(Danio rerio)
Actinopterygii si:ch211-89f7.1 35
  • 57 (a)
FP016199.1 35
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13893 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea ctg-1 35
  • 26 (a)
F20G2.3 35
  • 24 (a)
ctg-2 35
  • 23 (a)
cgr-1 35
  • 21 (a)
F28H7.8 35
  • 21 (a)
H41C03.1 35
  • 21 (a)
R03A10.5 35
  • 20 (a)
F18A11.2 35
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC14 35
  • 25 (a)
-- 35
  • 23 (a)
Species where no ortholog for SEC14L6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SEC14L6 Gene

Gene Tree for SEC14L6 (if available)
Gene Tree for SEC14L6 (if available)

Paralogs for SEC14L6 Gene

Paralogs for SEC14L6 Gene

(4) SIMAP similar genes for SEC14L6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC14L6: view

Variants for SEC14L6 Gene

Sequence variations from dbSNP and Humsavar for SEC14L6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000027493 -- 30,545,441(+) CCAGG(C/T)TGGAG intron-variant
rs1000280726 -- 30,547,692(+) TGTCA(A/G)TTCTG upstream-variant-2KB
rs1000312466 -- 30,543,583(+) GGCAG(C/T)CAGCG intron-variant, upstream-variant-2KB
rs1000387926 -- 30,541,490(+) CCCGT(C/T)TCTAC intron-variant
rs1000440377 -- 30,541,759(+) GCCCA(C/G)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L6 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv966101 CNV duplication 23825009

Variation tolerance for SEC14L6 Gene

Gene Damage Index Score: 3.36; 53.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC14L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L6 Gene

Disorders for SEC14L6 Gene

Relevant External Links for SEC14L6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC14L6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC14L6 Gene

Publications for SEC14L6 Gene

  1. The lipid-binding SEC14 domain. (PMID: 17428729) Saito K. … Mustelin T. (Biochim. Biophys. Acta 2007) 2 3 64
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4 64

Products for SEC14L6 Gene

Sources for SEC14L6 Gene

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