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Aliases for SEC14L6 Gene

Aliases for SEC14L6 Gene

  • SEC14 Like Lipid Binding 6 2 3 5
  • SEC14-Like 6 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 6 2
  • SEC14-Like 6 2

External Ids for SEC14L6 Gene

Previous GeneCards Identifiers for SEC14L6 Gene

  • GC22M030921

Summaries for SEC14L6 Gene

GeneCards Summary for SEC14L6 Gene

SEC14L6 (SEC14 Like Lipid Binding 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SEC14L4.

Additional gene information for SEC14L6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L6 Gene

Genomics for SEC14L6 Gene

GeneHancer (GH) Regulatory Elements for SEC14L6 Gene

Promoters and enhancers for SEC14L6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I030546 Promoter 0.7 EPDnew 550.8 0.0 -44 0.1 SCRT1 SCRT2 SEC14L6 GAL3ST1
GH22I030415 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.8 +125.3 125278 11.6 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 RNF215 ENSG00000272689 ENSG00000273350 MTFP1 RNU6-564P TUG1 SF3A1 TBC1D10A SEC14L3 PES1
GH22I030605 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 6.6 -61.4 -61354 5.5 PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF766 ZNF143 FOS SP5 JUNB TCN2 PES1 TUG1 MORC2 OSM SLC35E4 ENSG00000250318 SEC14L6 SMTN DUSP18
GH22I030355 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.5 +190.2 190206 2.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 CCDC157 SF3A1 RNF215 CASTOR1 SEC14L6 TBC1D10A
GH22I030385 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 6.3 +159.7 159720 2.1 HDGF ARNT INSM2 ARID4B KLF17 ZNF2 RAD21 ZNF335 GLIS2 ARID2 RNF215 CASTOR1 ENSG00000249590 TBC1D10A ENSG00000248751 OSM CCDC157 SF3A1 LIF ENSG00000181123
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEC14L6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SEC14L6 Gene

Genomic Locations for SEC14L6 Gene
chr22:30,522,799-30,546,717
(GRCh38/hg38)
Size:
23,919 bases
Orientation:
Minus strand
chr22:30,918,786-30,942,669
(GRCh37/hg19)

Genomic View for SEC14L6 Gene

Genes around SEC14L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L6 Gene

Proteins for SEC14L6 Gene

  • Protein details for SEC14L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B5MCN3-S14L6_HUMAN
    Recommended name:
    Putative SEC14-like protein 6
    Protein Accession:
    B5MCN3

    Protein attributes for SEC14L6 Gene

    Size:
    397 amino acids
    Molecular mass:
    45364 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEC14L6 Gene

Post-translational modifications for SEC14L6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SEC14L6 Gene

Domains & Families for SEC14L6 Gene

Gene Families for SEC14L6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SEC14L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SEC14L6: view

No data available for UniProtKB/Swiss-Prot for SEC14L6 Gene

Function for SEC14L6 Gene

Phenotypes From GWAS Catalog for SEC14L6 Gene

Phenotypes for SEC14L6 Gene

GenomeRNAi human phenotypes for SEC14L6:
genes like me logo Genes that share phenotypes with SEC14L6: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L6 Gene

Localization for SEC14L6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L6 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SEC14L6 Gene

Pathways & Interactions for SEC14L6 Gene

SuperPathways for SEC14L6 Gene

No Data Available

Interacting Proteins for SEC14L6 Gene

Gene Ontology (GO) - Biological Process for SEC14L6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SEC14L6 Gene

Drugs & Compounds for SEC14L6 Gene

No Compound Related Data Available

Transcripts for SEC14L6 Gene

mRNA/cDNA for SEC14L6 Gene

(10) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEC14L6 Gene

SEC14-like 6 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L6 Gene

No ASD Table

Relevant External Links for SEC14L6 Gene

GeneLoc Exon Structure for
SEC14L6
ECgene alternative splicing isoforms for
SEC14L6

Expression for SEC14L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC14L6 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L6 Gene

This gene is overexpressed in Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for SEC14L6 Gene

This gene is overexpressed in Adipocyte (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEC14L6 Gene



Protein tissue co-expression partners for SEC14L6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC14L6 Gene:

SEC14L6

SOURCE GeneReport for Unigene cluster for SEC14L6 Gene:

Hs.505605
genes like me logo Genes that share expression patterns with SEC14L6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC14L6 Gene

Orthologs for SEC14L6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC14L6 33 34
  • 98.24 (n)
cow
(Bos Taurus)
Mammalia SEC14L6 33
  • 85.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-89f7.1 34
  • 57 (a)
ManyToMany
FP016199.1 34
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13893 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ctg-1 34
  • 26 (a)
ManyToMany
F20G2.3 34
  • 24 (a)
ManyToMany
ctg-2 34
  • 23 (a)
ManyToMany
cgr-1 34
  • 21 (a)
ManyToMany
F28H7.8 34
  • 21 (a)
ManyToMany
H41C03.1 34
  • 21 (a)
ManyToMany
R03A10.5 34
  • 20 (a)
ManyToMany
F18A11.2 34
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC14 34
  • 25 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
Species where no ortholog for SEC14L6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SEC14L6 Gene

ENSEMBL:
Gene Tree for SEC14L6 (if available)
TreeFam:
Gene Tree for SEC14L6 (if available)

Paralogs for SEC14L6 Gene

Paralogs for SEC14L6 Gene

(4) SIMAP similar genes for SEC14L6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC14L6: view

Variants for SEC14L6 Gene

Sequence variations from dbSNP and Humsavar for SEC14L6 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000027493 -- 30,545,441(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000280726 -- 30,547,692(-) A/G upstream_transcript_variant
rs1000312466 -- 30,543,583(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000387926 -- 30,541,490(-) C/T intron_variant
rs1000440377 -- 30,541,759(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L6 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv966101 CNV duplication 23825009

Variation tolerance for SEC14L6 Gene

Gene Damage Index Score: 3.36; 53.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC14L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC14L6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L6 Gene

Disorders for SEC14L6 Gene

Additional Disease Information for SEC14L6

No disorders were found for SEC14L6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC14L6 Gene

Publications for SEC14L6 Gene

  1. The lipid-binding SEC14 domain. (PMID: 17428729) Saito K … Mustelin T (Biochimica et biophysica acta 2007) 2 3 58
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 58

Products for SEC14L6 Gene

Sources for SEC14L6 Gene

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