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Aliases for SEC14L5 Gene

Aliases for SEC14L5 Gene

  • SEC14 Like Lipid Binding 5 2 3 5
  • SEC14-Like 5 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 5 2
  • SEC14-Like Protein 5 3
  • SEC14-Like 5 3
  • PRELID4B 3
  • KIAA0420 4

External Ids for SEC14L5 Gene

Previous GeneCards Identifiers for SEC14L5 Gene

  • GC16P004932
  • GC16P005008

Summaries for SEC14L5 Gene

GeneCards Summary for SEC14L5 Gene

SEC14L5 (SEC14 Like Lipid Binding 5) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SEC14L1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L5 Gene

Genomics for SEC14L5 Gene

Regulatory Elements for SEC14L5 Gene

Enhancers for SEC14L5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F004611 1.2 ENCODE 10.4 -342.7 -342746 9.1 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF500 CREBBP MGRN1 VASN ALG1 SEC14L5 GLIS2 HMOX2 GC16M004615
GH16F004942 1.7 FANTOM5 Ensembl ENCODE 5.5 -13.9 -13945 4.4 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS ZNF263 ZNF500 LOC105371067 LOC105371066 ENSG00000261789 LINC01570 ENSG00000261442 SEPT12 SEC14L5 MGRN1 PPL
GH16F004976 1 Ensembl ENCODE 7.8 +18.5 18485 1.3 TFAP4 SAP130 ARID4B MAX RAD21 SLC30A9 CBX5 POLR2A ZNF26 CREM ZNF500 SEC14L5 GC16P004970 ENSG00000267072
GH16F004957 1 ENCODE 7.3 -0.3 -321 1.5 PKNOX1 ZNF133 ZFP64 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF263 SP3 SEC14L5 SEPT12 GC16M004952
GH16F004956 1.3 Ensembl ENCODE 5.5 -1.9 -1862 0.9 MLX ARID4B SIN3A ZNF48 ZNF2 ZNF121 SLC30A9 ZNF143 DEK ZNF263 SEC14L5 GC16M004952
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC14L5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEC14L5 Gene

4,958,317 bp from pter
5,019,158 bp from pter
60,842 bases
Plus strand

Genomic View for SEC14L5 Gene

Genes around SEC14L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L5 Gene

Proteins for SEC14L5 Gene

  • Protein details for SEC14L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SEC14-like protein 5
    Protein Accession:

    Protein attributes for SEC14L5 Gene

    696 amino acids
    Molecular mass:
    78942 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA24850.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SEC14L5 Gene

Post-translational modifications for SEC14L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEC14L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC14L5 Gene

Domains & Families for SEC14L5 Gene

Gene Families for SEC14L5 Gene

Suggested Antigen Peptide Sequences for SEC14L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 GOLD domain.
  • Contains 1 PRELI/MSF1 domain.
genes like me logo Genes that share domains with SEC14L5: view

Function for SEC14L5 Gene

Gene Ontology (GO) - Molecular Function for SEC14L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SEC14L5: view

Phenotypes for SEC14L5 Gene

GenomeRNAi human phenotypes for SEC14L5:
genes like me logo Genes that share phenotypes with SEC14L5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L5 Gene

Localization for SEC14L5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L5 gene
Compartment Confidence
cytosol 4
golgi apparatus 3
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SEC14L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC14L5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEC14L5 Gene

Pathways & Interactions for SEC14L5 Gene

SuperPathways for SEC14L5 Gene

No Data Available

Interacting Proteins for SEC14L5 Gene

Gene Ontology (GO) - Biological Process for SEC14L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SEC14L5: view

No data available for Pathways by source and SIGNOR curated interactions for SEC14L5 Gene

Transcripts for SEC14L5 Gene

mRNA/cDNA for SEC14L5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(242) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEC14L5 Gene

SEC14-like 5 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L5 Gene

No ASD Table

Relevant External Links for SEC14L5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC14L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC14L5 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x5.2), Brain - Putamen (basal ganglia) (x4.9), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for SEC14L5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.8) and Adipocyte (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEC14L5 Gene

Protein tissue co-expression partners for SEC14L5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC14L5 Gene:


SOURCE GeneReport for Unigene cluster for SEC14L5 Gene:

genes like me logo Genes that share expression patterns with SEC14L5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SEC14L5 Gene

Orthologs for SEC14L5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC14L5 34 35
  • 96.79 (n)
(Canis familiaris)
Mammalia SEC14L5 34 35
  • 89.3 (n)
(Bos Taurus)
Mammalia SEC14L5 34 35
  • 88.26 (n)
(Mus musculus)
Mammalia Sec14l5 34 16 35
  • 84.45 (n)
(Rattus norvegicus)
Mammalia Sec14l5 34
  • 84.2 (n)
(Monodelphis domestica)
Mammalia SEC14L5 35
  • 78 (a)
(Gallus gallus)
Aves SEC14L5 34 35
  • 74.95 (n)
(Anolis carolinensis)
Reptilia SEC14L5 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sec14l1 34
  • 72.79 (n)
(Danio rerio)
Actinopterygii si:dkey-237i9.1 35
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta retm 34 35
  • 57.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RETM_ANOGA 34
  • 54.69 (n)
(Caenorhabditis elegans)
Secernentea T23G5.2 35
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKL091C 34
  • 39.34 (n)
SEC14 35
  • 28 (a)
-- 35
  • 25 (a)
-- 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10399 35
  • 53 (a)
Species where no ortholog for SEC14L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC14L5 Gene

Gene Tree for SEC14L5 (if available)
Gene Tree for SEC14L5 (if available)

Paralogs for SEC14L5 Gene

Paralogs for SEC14L5 Gene

(6) SIMAP similar genes for SEC14L5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC14L5: view

Variants for SEC14L5 Gene

Sequence variations from dbSNP and Humsavar for SEC14L5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1008072 -- 5,015,355(+) CTCCC(C/T)GCAGC utr-variant-3-prime
rs10153168 -- 4,960,734(+) atcct(C/G)gtgtc intron-variant
rs1019251 -- 4,964,678(-) CAGGA(A/G)GATCA intron-variant
rs1019252 -- 4,960,119(-) GGGTG(A/C)AAAGA intron-variant
rs10852645 -- 4,961,485(+) CACCA(C/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L5 Gene

Variant ID Type Subtype PubMed ID
esv2422516 CNV deletion 17116639
esv25186 CNV gain 19812545
esv2750431 CNV deletion 23290073
esv2750432 CNV deletion 23290073
esv2760069 CNV gain+loss 17122850
esv2761893 CNV loss 21179565
nsv9339 CNV loss 18304495
nsv817715 CNV gain 17921354
nsv571303 CNV loss 21841781
nsv528586 CNV gain 19592680
nsv457360 CNV loss 19166990
nsv428318 CNV gain 18775914
nsv1131222 CNV deletion 24896259
nsv1046986 CNV gain 25217958
nsv1042612 CNV loss 25217958
nsv1039730 CNV loss 25217958
nsv1039432 CNV loss 25217958
nsv1038475 CNV gain 25217958
esv3892763 CNV loss 25118596
esv3892762 CNV gain 25118596
esv3637714 CNV gain 21293372
esv3637713 CNV gain 21293372
esv34300 CNV gain 17911159

Variation tolerance for SEC14L5 Gene

Residual Variation Intolerance Score: 5.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC14L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L5 Gene

Disorders for SEC14L5 Gene

Relevant External Links for SEC14L5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC14L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC14L5 Gene

Publications for SEC14L5 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. The lipid-binding SEC14 domain. (PMID: 17428729) Saito K. … Mustelin T. (Biochim. Biophys. Acta 2007) 2 3 64
  3. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx J.J. … Ophoff R.A. (Mol. Psychiatry 2013) 3 64
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 4 64

Products for SEC14L5 Gene

Sources for SEC14L5 Gene

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