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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC14L5 Gene

protein-coding   GIFtS: 41
GCID: GC16P005008

SEC14-Like 5 (S. Cerevisiae)

  Search for SEC14L5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SEC14-Like 5 (S. Cerevisiae)1 2
PRELID4B2
SEC14-Like Protein 52
KIAA04203

External Ids:    HGNC: 290321   Entrez Gene: 97172   Ensembl: ENSG000001031847   UniProtKB: O433043   

Export aliases for SEC14L5 gene to outside databases

Previous GC identifer: GC16P004932


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SEC14L5 Gene: 
SEC14L5 (SEC14-like 5 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is ENSG00000249590.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC14L5 gene promoter:
         MAZR   NF-AT   NF-AT2   POU2F1   POU2F1b   POU2F1a   NF-AT3   ARP-1   POU2F1c   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SEC14L5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC14L5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

SEC14L5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC14L5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P005008:  view genomic region     (about GC identifiers)

Start:
5,008,318 bp from pter      End:
5,069,159 bp from pter
Size:
60,842 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S14L5_HUMAN, O43304 (See protein sequence)
Recommended Name: SEC14-like protein 5  
Size: 696 amino acids; 78942 Da
Sequence caution: Sequence=BAA24850.2; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for SEC14L5: NX_O43304

Explore proteomics data for SEC14L5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43304

  • SEC14L5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEC14L5 Protein Expression
    REFSEQ proteins: NP_055507.1  
    ENSEMBL proteins: 
     ENSP00000251170   ENSP00000468423  

    Human Recombinant Protein Products for SEC14L5: 
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    Cloud-Clone Corp. Proteins for SEC14L5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0016021integral to membrane IEA--

    SEC14L5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR006797 PRELI/MSF1
     IPR001071 CRAL-bd_toc_tran
     IPR009038 GOLD
     IPR011074 CRAL/TRIO_N_dom
     IPR001251 CRAL-TRIO_dom

    Graphical View of Domain Structure for InterPro Entry O43304

    ProtoNet protein and cluster: O43304

    4 Blocks protein domains:
    IPB001071 Cellular retinaldehyde-binding protein signature
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
    IPB006797 MSF1-like conserved region
    IPB008273 Cellular retinaldehyde-binding/triple function


    UniProtKB/Swiss-Prot: S14L5_HUMAN, O43304
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 GOLD domain
    Similarity: Contains 1 PRELI/MSF1 domain


    SEC14L5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
         
    SEC14L5 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC14L5

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----

    SEC14L5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Search CenterWatch for drugs/clinical trials and news about SEC14L5 / S14L5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for SEC14L5 gene: 
    NM_014692.1  

    Unigene Cluster for SEC14L5:

    SEC14-like 5 (S. cerevisiae)
    Hs.512856  [show with all ESTs]
    Unigene Representative Sequence: NM_014692
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251170(uc002cye.2) ENST00000587469
    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC14L5 (see all 31):
    hsa-miR-4254 hsa-miR-4286 hsa-miR-185* hsa-let-7d hsa-miR-202 hsa-miR-3614-3p hsa-let-7c hsa-miR-548s
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Additional mRNA sequence: 

    AB007880.2 BC045685.1 

    1 DOTS entry:

    DT.111637 

    24/242 AceView cDNA sequences (see all 242):

    BM852978 AY359073 BM791409 CR619322 CA495409 CB124924 AI371094 AA700910 
    NM_019109 BM725132 BM801720 AI273221 BX376384 H42894 CB158360 CA391104 
    AA380399 BM559894 CB993327 CB108493 BF438369 AL539861 BQ935553 BQ688685 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC14L5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEC14L5 Expression
    About this image


    See SEC14L5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC14L5

    SOURCE GeneReport for Unigene cluster: Hs.512856
        SABiosciences Custom PCR Arrays for SEC14L5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC14L5 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec14l51 , 5 SEC14-like 5 (S. cerevisiae)1, 5 84.39(n)1
    88.07(a)1
      16 (2.50 cM)5
    6651191  NM_001127725.11  NP_001121197.11 
     51471095 
    chicken
    (Gallus gallus)
    Aves SEC14L51 SEC14-like 5 (S. cerevisiae) 74.8(n)
    77.92(a)
      416396  XM_414710.3  XP_414710.3 
    lizard
    (Anolis carolinensis)
    Reptilia SEC14L56
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343263.1(1040129-1070363)
    fruit fly
    (Drosophila melanogaster)
    Insecta retm1 real-time 57.11(n)
    49.29(a)
      33899  NM_135184.2  NP_609028.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T23G5.26
    CRAL-TRIO domain-containing protein T23G5.2
    45(a)
    1 → many
    III(9231393-9236323)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YKL091C)4 Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine more   --   11(270650-269718) 853771  NP_012832.1 


    ENSEMBL Gene Tree for SEC14L5 (if available)
    TreeFam Gene Tree for SEC14L5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC14L5 gene
    ENSG000002495902  SEC14L12  SEC14L62  SEC14L22  SEC14L32  SEC14L42  
    6 SIMAP similar genes for SEC14L5 using alignment to 2 protein entries:     S14L5_HUMAN (see all proteins):
    SEC14L1    DKFZp686C06176    SEC14L2    SEC14L3    SEC14L4    Em

    SEC14L5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1975 SNPs in SEC14L5 are shown (see all 1975)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797607101,2
    F--5006375(+) ATTTCC/TGCCCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1113276801,2
    C,F--5006389(+) TTACCT/GAAGCC 1 -- us2k12Minor allele frequency- G:0.05CSA WA 120
    rs1452985701,2
    --5006476(+) AGGCAC/GCCACT 1 -- us2k10--------
    rs584823491,2
    C--5006502(+) GCTCA-/CAGTCTC 1 -- us2k11Minor allele frequency- CA:0.00NA 2
    rs129254841,2
    C,F,H--5006524(+) GACCTC/GCAGGA 1 -- us2k111Minor allele frequency- G:0.26NS EA NA WA 762
    rs596406581,2
    C,F--5006541(+) AGATAT/CATAAA 1 -- us2k17Minor allele frequency- C:0.28NA WA EA 366
    rs340465271,2
    C--5006557(+) TAAAT-/GCAATAT 1 -- us2k11Minor allele frequency- GC:0.00NA 2
    rs129297161,2
    C,F--5006600(+) AGGTGA/GTTTTC 1 -- us2k19Minor allele frequency- G:0.26NA WA EA 498
    rs1917208661,2
    C--5006676(+) CCCCTG/TCTTGA 1 -- us2k10--------
    rs1825421251,2
    --5006681(+) GCTTGA/GAGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEC14L5 (5008318 - 5069159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for SEC14L5 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750431CNV Deletion23290073
    esv2422516CNV Deletion17116639
    esv2750432CNV Deletion23290073
    nsv905254CNV Loss21882294
    nsv905255CNV Loss21882294
    nsv9339CNV Loss18304495
    nsv457360CNV Loss19166990
    nsv528586CNV Gain19592680
    nsv817715CNV Gain17921354
    esv25186CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC14L5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SEC14L5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
    2. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (2013)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9717 HGNC: 29032 AceView: ALG1andKIAA0420 Ensembl:ENSG00000103184 euGenes: HUgn9717
    ECgene: SEC14L5 H-InvDB: SEC14L5

    (According to HUGE)
    About This Section
    HUGE: KIAA0420

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC14L5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC14L5 gene:
    Search GeneIP for patents involving SEC14L5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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