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SEC14L5 Gene

protein-coding   GIFtS: 43
GCID: GC16P005008

SEC14-Like 5 (S. Cerevisiae)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SEC14-Like 5 (S. Cerevisiae)1 2
PRELID4B2
SEC14-Like Protein 52
KIAA04203

External Ids:    HGNC: 290321   Entrez Gene: 97172   Ensembl: ENSG000001031847   UniProtKB: O433043   

Export aliases for SEC14L5 gene to outside databases

Previous GC identifer: GC16P004932


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SEC14L5 Gene:
SEC14L5 (SEC14-like 5 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is ENSG00000249590.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC14L5 gene promoter:
         MAZR   NF-AT   NF-AT2   POU2F1   POU2F1b   POU2F1a   NF-AT3   ARP-1   POU2F1c   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEC14L5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC14L5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

SEC14L5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC14L5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P005008:  view genomic region     (about GC identifiers)

Start:
5,008,318 bp from pter      End:
5,069,159 bp from pter
Size:
60,842 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S14L5_HUMAN, O43304 (See protein sequence)
Recommended Name: SEC14-like protein 5  
Size: 696 amino acids; 78942 Da
Sequence caution: Sequence=BAA24850.2; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for SEC14L5: NX_O43304

Explore proteomics data for SEC14L5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SEC14L5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055507.1  
    ENSEMBL proteins: 
     ENSP00000251170   ENSP00000468423  

    SEC14L5 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC14L5

     
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    LSBio Antibodies in human, mouse, rat for SEC14L5

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    Cloud-Clone Corp. ELISAs for SEC14L5
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    Search eBioscience for ELISAs for SEC14L5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR006797 PRELI/MSF1
     IPR001071 CRAL-bd_toc_tran
     IPR001251 CRAL-TRIO_dom
     IPR009038 GOLD
     IPR011074 CRAL/TRIO_N_dom

    Graphical View of Domain Structure for InterPro Entry O43304

    ProtoNet protein and cluster: O43304

    4 Blocks protein domains:
    IPB001071 Cellular retinaldehyde-binding protein signature
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
    IPB006797 MSF1-like conserved region
    IPB008273 Cellular retinaldehyde-binding/triple function


    UniProtKB/Swiss-Prot: S14L5_HUMAN, O43304
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 GOLD domain
    Similarity: Contains 1 PRELI/MSF1 domain


    Find genes that share domains with SEC14L5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
         
    Find genes that share ontologies with SEC14L5           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC14L5
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SEC14L5 (see all 31):
    hsa-miR-4254 hsa-miR-4286 hsa-miR-185* hsa-let-7d hsa-miR-202 hsa-miR-3614-3p hsa-let-7c hsa-miR-548s
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SEC14L5

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC14L5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SEC14L5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC14L5
    Interactions:

        Search GeneGlobe Interaction Network for SEC14L5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC14L5 (ENSP000002511704) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARFGAP1ENSP000003146154STRING: ENSP00000314615
    ARFRP1ENSP000003268844STRING: ENSP00000326884
    ARL1ENSP000002616364STRING: ENSP00000261636
    MOSPD2ENSP000003698604STRING: ENSP00000369860
    PFDN5ENSP000003341884STRING: ENSP00000334188
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----

    Find genes that share ontologies with SEC14L5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC14L5 (S14L5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEC14L5 gene: 
    NM_014692.1  

    Unigene Cluster for SEC14L5:

    SEC14-like 5 (S. cerevisiae)
    Hs.512856  [show with all ESTs]
    Unigene Representative Sequence: NM_014692
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251170(uc002cye.2) ENST00000587469
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SEC14L5 (see all 31):
    hsa-miR-4254 hsa-miR-4286 hsa-miR-185* hsa-let-7d hsa-miR-202 hsa-miR-3614-3p hsa-let-7c hsa-miR-548s
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat SEC14L5
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC14L5 (NM_014692)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC14L5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC14L5
      QuantiTect SYBR Green Assays in human, mouse, rat SEC14L5
      QuantiFast Probe-based Assays in human, mouse, rat SEC14L5

    Additional mRNA sequence: 

    AB007880.2 BC045685.1 

    1 DOTS entry:

    DT.111637 

    Selected AceView cDNA sequences (see all 242):

    BM852978 AY359073 BM791409 CR619322 CA495409 CB124924 AI371094 AA700910 
    NM_019109 BM725132 BM801720 AI273221 BX376384 H42894 CB158360 CA391104 
    AA380399 BM559894 CB993327 CB108493 BF438369 AL539861 BQ935553 BQ688685 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEC14L5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEC14L5 Expression
    About this image

    SEC14L5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC14L5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512856
        Custom PCR Arrays for SEC14L5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC14L5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec14l51 , 5 SEC14-like 5 (S. cerevisiae)1, 5 84.45(n)1
    88.11(a)1
      16 (2.50 cM)5
    6651191  NM_001127725.11  NP_001121197.11 
     51471095 
    chicken
    (Gallus gallus)
    Aves SEC14L51 SEC14-like 5 (S. cerevisiae) 74.95(n)
    78.27(a)
      416396  XM_414710.4  XP_414710.3 
    lizard
    (Anolis carolinensis)
    Reptilia SEC14L56
    SEC14-like 5 (S. cerevisiae)
    66(a)
    1 ↔ 1
    GL343263.1(1040129-1070363)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sec14l11 SEC14-like 1 72.79(n)
    74.93(a)
      100124776  NM_001102755.1  NP_001096225.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-237i9.16
    si:dkey-237i9.1
    65(a)
    many ↔ many
    6(19781671-19798787) ENSDARG00000070336
    fruit fly
    (Drosophila melanogaster)
    Insecta retm1 real-time 57.7(n)
    49.28(a)
      33899  NM_135184.3  NP_609028.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T23G5.26
    Protein T23G5.2, isoform a
    45(a)
    1 → many
    III(9231393-9236322) WBGene00011962
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YKL091C)4
    YKL091C1
    Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine more4
    YKL091C1
    39.34(n)1
    29.1(a)1
      11(270650-269718)4
    8537711, 4  NP_012832.11, 4 


    ENSEMBL Gene Tree for SEC14L5 (if available)
    TreeFam Gene Tree for SEC14L5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEC14L5 gene
    ENSG000002495902  SEC14L12  SEC14L62  SEC14L22  SEC14L32  SEC14L42  
    6 SIMAP similar genes for SEC14L5 using alignment to 2 protein entries:     S14L5_HUMAN (see all proteins):
    SEC14L1    DKFZp686C06176    SEC14L2    SEC14L3    SEC14L4    Em

    Find genes that share paralogs with SEC14L5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEC14L5 (see all 1975)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797607101,2
    F--5006375(+) ATTTCC/TGCCCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1113276801,2
    C,F--5006389(+) TTACCT/GAAGCC 1 -- us2k12Minor allele frequency- G:0.05CSA WA 120
    rs1452985701,2
    --5006476(+) AGGCAC/GCCACT 1 -- us2k10--------
    rs584823491,2
    C--5006502(+) GCTCA-/CAGTCTC 1 -- us2k11Minor allele frequency- CA:0.00NA 2
    rs129254841,2
    C,F,H--5006524(+) GACCTC/GCAGGA 1 -- us2k111Minor allele frequency- G:0.26NS EA NA WA 762
    rs596406581,2
    C,F--5006541(+) AGATAT/CATAAA 1 -- us2k17Minor allele frequency- C:0.28NA WA EA 366
    rs340465271,2
    C--5006557(+) TAAAT-/GCAATAT 1 -- us2k11Minor allele frequency- GC:0.00NA 2
    rs129297161,2
    C,F--5006600(+) AGGTGA/GTTTTC 1 -- us2k19Minor allele frequency- G:0.26NA WA EA 498
    rs1917208661,2
    C--5006676(+) CCCCTG/TCTTGA 1 -- us2k10--------
    rs1825421251,2
    --5006681(+) GCTTGA/GAGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEC14L5 (5008318 - 5069159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SEC14L5 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750431CNV Deletion23290073
    esv2422516CNV Deletion17116639
    esv2750432CNV Deletion23290073
    nsv905254CNV Loss21882294
    nsv905255CNV Loss21882294
    nsv9339CNV Loss18304495
    nsv457360CNV Loss19166990
    nsv528586CNV Gain19592680
    nsv817715CNV Gain17921354
    esv25186CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEC14L5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SEC14L5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    2. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (Mol. Psychiatry 2013)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (DNA Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9717 HGNC: 29032 AceView: ALG1andKIAA0420 Ensembl:ENSG00000103184 euGenes: HUgn9717
    ECgene: SEC14L5 H-InvDB: SEC14L5

    (According to HUGE)
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    HUGE: KIAA0420

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEC14L5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEC14L5 gene:
    Search GeneIP for patents involving SEC14L5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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