SEC14L4 Gene
protein-coding GIFtS : 49
GCID: GC22 M030884
SEC14-like 4 (S. cerevisiae)
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Aliasesfor SEC14L4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases SEC14-Like 4 (S. Cerevisiae) 1 2 TAP31 2 3 5 Tocopherol-Associated Protein 32 3 DJ130H16.51 SEC14-Like Protein 42 SEC14p-Like Protein TAP32
Export aliases for SEC14L4 gene to outside databases Previous GC identifers: GC22M027579 GC22M029209 GC22M013847
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Summariesfor SEC14L4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SEC14L4 : The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2009) UniProtKB/Swiss-Prot: S14L4_HUMAN, Q9UDX3 Function : Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands liketocopherol, squalene and phospholipids
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Genomic Viewsfor SEC14L4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000022.10 NC_018933.1 NT_011520.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SEC14L4 gene promoter: STAT5B GR GCNF GR-beta Max GCNF-1 c-Myb GR-alpha GCNF-2 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for SEC14L4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC14L4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.1 SEC14L4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22M030884: view genomic region
(about GC identifiers )
Start:
30,884,889 bp from pter
End:
30,901,698 bp from pter
Size:
16,810 bases
Orientation:
minus strand
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Proteinsfor SEC14L4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: S14L4_HUMAN, Q9UDX3 (See
protein sequence )Recommended Name: SEC14-like protein 4 Size : 406 amino acids; 46644 Da
Secondary accessions : A5D6W7 A6NCV4Alternative splicing : 2 isoforms : Q9UDX3-1 Q9UDX3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SEC14L4: NX_Q9UDX3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UDX3 SEC14L4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001154840.1 NP_777637.1 ENSEMBL proteins: ENSP00000255858 ENSP00000317617 ENSP00000314163 ENSP00000371412 ENSP00000440848 ENSP00000376525 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA -- GO:0016021 integral to membrane
IEA --
SEC14L4 for ontologies About GeneDecksing SEC14L4 Antibody Products: Assay Products for SEC14L4:
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Protein
Domains / Familiesfor SEC14L4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SEC14L4 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9UDX3 ProtoNet protein and cluster: Q9UDX3
3 Blocks protein families : IPB001071 Cellular retinaldehyde-binding protein signature IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) IPB008273 Cellular retinaldehyde-binding/triple function UniProtKB/Swiss-Prot: S14L4_HUMAN, Q9UDX3 Similarity : Contains 1 CRAL-TRIO domainSimilarity : Contains 1 GOLD domain
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Functionfor SEC14L4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: S14L4_HUMAN, Q9UDX3 Function : Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands liketocopherol, squalene and phospholipids
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SEC14L4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SEC14L4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SEC14L4 (NM_174977 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC14L4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SEC14L4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L4
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005215 transporter activity
IEA -- GO:0008289 lipid binding
IEA --
SEC14L4 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for SEC14L4 :
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Pathways & Interactionsfor SEC14L4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC14L4 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for SEC14L4 (ENSP00000255858 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006810 transport
-- --
SEC14L4 for ontologies About GeneDecksing
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Drugs & Compoundsfor SEC14L4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SEC14L4 1 HMDB Compound for SEC14L4 About this table 1 DrugBank Compound for SEC14L4 About this table Search CenterWatch for drugs/clinical trials and news about SEC14L4 / S14L4
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Transcriptsfor SEC14L4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SEC14L4 gene (2 alternative transcripts): NM_001161368.1 NM_174977.3 Unigene Cluster for SEC14L4:
SEC14-like 4 (S. cerevisiae) Hs.517541 [show with all ESTs ] Unigene Representative Sequence: AK093418 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000255858 ENST00000321205 ENST00000320982 ENST00000381982 ENST00000540456 (uc003aid.2 uc011akz.1 uc003aie.2 )ENST00000392772 (uc003aif.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SEC14L4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SEC14L4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SEC14L4 (NM_174977 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC14L4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SEC14L4
Additional cDNA sequence: AK092002.1 AK093418.1 AK093448.1 AY158085.1 BC136358.1 BC136359.1 BC139912.1 CR456346.1 FJ824055.1
4 DOTS entries : DT.109027 DT.100020119
DT.120641042 DT.100751285 21 AceView cDNA sequences :
AA813154 AY158085 NM_174977 CR456346 BX284067 AX747303 AK093448 BU584107 AK093418 BU584108 AX748114 AK092002 AA025930 T72380 BG740064 R12499 BX090813 AI016396 BU584106 AA025889 R09898 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L4 About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 SP1 :     -             SP2 :                
ECgene alternative splicing isoforms for SEC14L4
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Expression for SEC14L4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SEC14L4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGTGCATATA
About this image SEC14L4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Bone Zeugopod Growth Plate Bone Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SEC14L4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SEC14L4 SOURCE GeneReport for Unigene cluster: Hs.517541 SABiosciences Custom PCR Arrays for SEC14L4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SEC14L4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SEC14L4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SEC14L4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SEC14L4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L4
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Orthologsfor SEC14L4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for SEC14L4 gene from 7/20 species (see all 20 ) About this table
ENSEMBL Gene Tree for SEC14L4 (if available)TreeFam Gene Tree for SEC14L4 (if available)
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Paralogsfor SEC14L4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SEC14L4 gene ENSG00000249590 2 SEC14L1 2 SEC14L6 2 SEC14L2 2 SEC14L5 2 SEC14L3 2 7 SIMAP similar genes for SEC14L4 using alignment to 6 protein entries: S14L4_HUMAN (see all proteins ):SEC14L6 SEC14L3 SEC14L2 SEC14L1 DKFZp686C06176 SEC14L5 Em
SEC14L4 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for SEC14L4 PGOHUM00000250323
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Genomic Variantsfor SEC14L4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 22 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SEC14L4 (30884889 - 30901698 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SEC14L4: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SEC14L4
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Disorders
/ Diseasesfor SEC14L4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SEC14L4 for disorders About MalaCards
SEC14L4 for disorders About GeneDecksing
OMIM gene information: 612825
OMIM disorders : --Export disorders for SEC14L4 gene to outside databases
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Publicationsfor SEC14L4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SEC14L4 gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with SEC14L4) Utopia : connect your pdf to the dynamic world of online information
Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PubMed id 12757856) 1 , 2 Kempna P.... Azzi A. (2003) The DNA sequence of human chromosome 22. (PubMed id 10591208) 1 , 2 Dunham I....O'Brien K.P. (1999) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Alternative splicing and gene polymorphism of the human TAP3/SEC14L4 gene. (PubMed id 20012369) 1 Kempna P.... Zingg J.M. (2009) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423) 7 Imming P....Meyer A. (2006) How many drug targets are there? (PubMed id 17139284) 7 Overington J.P....Hopkins A.L. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004)
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External Searches for SEC14L4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SEC14L4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SEC14L4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SEC14L4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SEC14L4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SEC14L4 gene: Search GeneIP for patents involving SEC14L4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SEC14L4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SEC14L4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SEC14L4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SEC14L4 OriGene Protein Over-expression Lysate for SEC14L4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SEC14L4 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SEC14L4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SEC14L4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SEC14L4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SEC14L4 OriGene Custom Protein Services for SEC14L4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC14L4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SEC14L4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC14L4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SEC14L4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SEC14L4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SEC14L4
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SEC14L4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L4
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SEC14L4
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