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Aliases for SEC14L4 Gene

Aliases for SEC14L4 Gene

  • SEC14 Like Lipid Binding 4 2 3 5
  • Tocopherol-Associated Protein 3 2 3 4
  • TAP3 3 4
  • SEC14-Like 4 (S. Cerevisiae) 2
  • SEC14-Like Lipid Binding 4 2
  • SEC14p-Like Protein TAP3 3
  • SEC14-Like Protein 4 3
  • SEC14-Like 4 3

External Ids for SEC14L4 Gene

Previous GeneCards Identifiers for SEC14L4 Gene

  • GC22M027579
  • GC22M029209
  • GC22M030884
  • GC22M013847

Summaries for SEC14L4 Gene

Entrez Gene Summary for SEC14L4 Gene

  • The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]

GeneCards Summary for SEC14L4 Gene

SEC14L4 (SEC14 Like Lipid Binding 4) is a Protein Coding gene. GO annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is SEC14L6.

UniProtKB/Swiss-Prot for SEC14L4 Gene

  • Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L4 Gene

Genomics for SEC14L4 Gene

Regulatory Elements for SEC14L4 Gene

Enhancers for SEC14L4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F030505 0.9 ENCODE 24.3 +0.2 156 0.7 ELF3 ATF1 MLX DMAP1 THRB ZSCAN9 RAD21 RARA GATA4 CREM SEC14L4 SDC4P
GH22F030234 1.8 FANTOM5 Ensembl ENCODE 7.6 +259.0 258981 24.6 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF416 ZNF143 FOS TUG1 HORMAD2-AS1 LIF MGC20647 MORC2 SEC14L4 DUSP18 THOC5 ENSG00000181123 ASCC2
GH22F030275 1.5 FANTOM5 Ensembl ENCODE 7.5 +227.7 227711 4.8 ATF1 ZNF121 GLIS2 CREM EGR2 ZNF362 NR2F2 SMARCA4 ZNF341 GLIS1 OSM LIF TBC1D10A ENSG00000248751 SEC14L2 ENSG00000232530 ENSG00000249590 SLC35E4 SEC14L4 RNF215
GH22F030223 1.2 Ensembl ENCODE 6.7 +279.3 279308 6.5 ELF3 PKNOX1 INSM2 GLI4 RAD21 ZEB1 RFX5 GLIS2 ZNF366 RCOR1 LIF TBC1D10A ENSG00000248751 SEC14L2 ENSG00000249590 SEC14L4 MTMR3 THOC5 ENSG00000181123 ENSG00000232530
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC14L4 on UCSC Golden Path with GeneCards custom track

Promoters for SEC14L4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001842944 11 201 KLF1 ZNF511 POLR2A MXD3 MXD4 DMAP1

Genomic Location for SEC14L4 Gene

30,488,890 bp from pter
30,505,711 bp from pter
16,822 bases
Minus strand

Genomic View for SEC14L4 Gene

Genes around SEC14L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC14L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC14L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L4 Gene

Proteins for SEC14L4 Gene

  • Protein details for SEC14L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SEC14-like protein 4
    Protein Accession:
    Secondary Accessions:
    • A5D6W7
    • A6NCV4

    Protein attributes for SEC14L4 Gene

    406 amino acids
    Molecular mass:
    46644 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SEC14L4 Gene

    Alternative splice isoforms for SEC14L4 Gene


neXtProt entry for SEC14L4 Gene

Post-translational modifications for SEC14L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEC14L4 Gene

Domains & Families for SEC14L4 Gene

Gene Families for SEC14L4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 GOLD domain.
genes like me logo Genes that share domains with SEC14L4: view

Function for SEC14L4 Gene

Molecular function for SEC14L4 Gene

UniProtKB/Swiss-Prot Function:
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Gene Ontology (GO) - Molecular Function for SEC14L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with SEC14L4: view
genes like me logo Genes that share phenotypes with SEC14L4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC14L4 Gene

Localization for SEC14L4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC14L4 gene
Compartment Confidence
cytosol 3
peroxisome 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC14L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC14L4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEC14L4 Gene

Pathways & Interactions for SEC14L4 Gene

SuperPathways for SEC14L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEC14L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SEC14L4: view

No data available for Pathways by source and SIGNOR curated interactions for SEC14L4 Gene

Drugs & Compounds for SEC14L4 Gene

(1) Drugs for SEC14L4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 406,403

(1) Additional Compounds for SEC14L4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-Tetracosahexaene
  • (E,E,E,E)-Squalene
  • 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • All-trans-Squalene
  • Nikko Squalane EX
genes like me logo Genes that share compounds with SEC14L4: view

Transcripts for SEC14L4 Gene

Unigene Clusters for SEC14L4 Gene

SEC14-like 4 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: -

Relevant External Links for SEC14L4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEC14L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEC14L4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEC14L4 Gene

This gene is overexpressed in Liver (x29.4), Testis (x7.3), and Lung (x4.2).

Protein differential expression in normal tissues from HIPED for SEC14L4 Gene

This gene is overexpressed in Liver (20.7), Testis (16.5), Gallbladder (9.9), Ovary (9.2), and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC14L4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEC14L4 Gene:


SOURCE GeneReport for Unigene cluster for SEC14L4 Gene:

genes like me logo Genes that share expression patterns with SEC14L4: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SEC14L4 Gene

Orthologs for SEC14L4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEC14L4 34 35
  • 98.93 (n)
(Canis familiaris)
Mammalia SEC14L4 34 35
  • 86.78 (n)
(Bos Taurus)
Mammalia SEC14L4 34 35
  • 86.28 (n)
(Mus musculus)
Mammalia Sec14l4 34 16 35
  • 85.32 (n)
(Rattus norvegicus)
Mammalia Sec14l4 34
  • 83.42 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
(Gallus gallus)
Aves -- 35
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
(Danio rerio)
Actinopterygii si:ch211-89f7.1 35
  • 59 (a)
FP016199.1 35
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005701 34
  • 52.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13893 34 35
  • 49.16 (n)
(Caenorhabditis elegans)
Secernentea ctg-1 35
  • 28 (a)
ctg-2 35
  • 24 (a)
H41C03.1 35
  • 23 (a)
cgr-1 35
  • 22 (a)
F20G2.3 35
  • 22 (a)
F18A11.2 35
  • 20 (a)
F28H7.8 35
  • 19 (a)
R03A10.5 35
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC14 35
  • 27 (a)
-- 35
  • 26 (a)
Species where no ortholog for SEC14L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SEC14L4 Gene

Gene Tree for SEC14L4 (if available)
Gene Tree for SEC14L4 (if available)

Paralogs for SEC14L4 Gene

Paralogs for SEC14L4 Gene

(7) SIMAP similar genes for SEC14L4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SEC14L4: view

Variants for SEC14L4 Gene

Sequence variations from dbSNP and Humsavar for SEC14L4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10543659 -- 30,502,854(+) CTTGT(-/TA)TTATT intron-variant, upstream-variant-2KB
rs10558789 -- 30,501,847(+) CGCAC(-/AT)ATATA intron-variant, upstream-variant-2KB
rs10593638 -- 30,493,100(+) AAAAA(-/AA)GAAAA intron-variant
rs111263559 -- 30,491,427(+) AGGTA(A/G)GGGCC intron-variant
rs111316604 -- 30,499,333(+) CTGCT(G/T)CGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L4 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv955507 CNV deletion 24416366

Variation tolerance for SEC14L4 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.84; 97.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC14L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L4 Gene

Disorders for SEC14L4 Gene

Relevant External Links for SEC14L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEC14L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC14L4 Gene

Publications for SEC14L4 Gene

  1. Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PMID: 12757856) Kempna P. … Azzi A. (Free Radic. Biol. Med. 2003) 2 3 4 64
  2. Alternative splicing and gene polymorphism of the human TAP3/SEC14L4 gene. (PMID: 20012369) Kempna P. … Zingg J.M. (Mol. Biol. Rep. 2010) 2 3 64
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SEC14L4 Gene

Sources for SEC14L4 Gene

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