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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC14L4 Gene

protein-coding   GIFtS: 49
GCID: GC22M030884

SEC14-like 4 (S. cerevisiae)

  Search for SEC14L4
in our new
 Human Malady Compendium 
Biological research products
for SEC14L4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SEC14-Like 4 (S. Cerevisiae)1 2
TAP31 2 3 5
Tocopherol-Associated Protein 32 3
DJ130H16.51
SEC14-Like Protein 42
SEC14p-Like Protein TAP32

External Ids:    HGNC: 206271   Entrez Gene: 2849042   Ensembl: ENSG000001334887   OMIM: 6128255   UniProtKB: Q9UDX33   

Export aliases for SEC14L4 gene to outside databases

Previous GC identifers: GC22M027579 GC22M029209 GC22M013847


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC14L4:
The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene.
The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived
transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The
specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: S14L4_HUMAN, Q9UDX3
Function: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like
tocopherol, squalene and phospholipids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC14L4 gene promoter:
         STAT5B   GR   GCNF   GR-beta   Max   GCNF-1   c-Myb   GR-alpha   GCNF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC14L4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC14L4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC14L4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.1

SEC14L4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC14L4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M030884:  view genomic region     (about GC identifiers)

Start:
30,884,889 bp from pter      End:
30,901,698 bp from pter
Size:
16,810 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S14L4_HUMAN, Q9UDX3 (See protein sequence)
Recommended Name: SEC14-like protein 4  
Size: 406 amino acids; 46644 Da
Secondary accessions: A5D6W7 A6NCV4
Alternative splicing: 2 isoforms:  Q9UDX3-1   Q9UDX3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC14L4: NX_Q9UDX3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UDX3

  • SEC14L4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001154840.1  NP_777637.1  

    ENSEMBL proteins: 
     ENSP00000255858   ENSP00000317617   ENSP00000314163   ENSP00000371412   ENSP00000440848  
     ENSP00000376525  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEC14L4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0016021integral to membrane IEA--


    SEC14L4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SEC14L4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001071 CRAL-bd_toc_tran
     IPR009038 GOLD
     IPR011074 CRAL/TRIO_N_dom
     IPR001251 CRAL-TRIO_dom

    Graphical View of Domain Structure for InterPro Entry Q9UDX3

    ProtoNet protein and cluster: Q9UDX3

    3 Blocks protein families:
    IPB001071 Cellular retinaldehyde-binding protein signature
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
    IPB008273 Cellular retinaldehyde-binding/triple function


    UniProtKB/Swiss-Prot: S14L4_HUMAN, Q9UDX3
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 GOLD domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: S14L4_HUMAN, Q9UDX3
    Function: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like
    tocopherol, squalene and phospholipids

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0008289lipid binding IEA--


    SEC14L4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SEC14L4:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC14L4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SEC14L4 (ENSP000002558584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----


    SEC14L4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC14L4

    1 HMDB Compound for SEC14L4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Squalene(E,E,E,E)-Squalene (see all 10)111-02-4--

    1 DrugBank Compound for SEC14L4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about SEC14L4 / S14L4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC14L4 gene (2 alternative transcripts): 
    NM_001161368.1  NM_174977.3  

    Unigene Cluster for SEC14L4:

    SEC14-like 4 (S. cerevisiae)
    Hs.517541  [show with all ESTs]
    Unigene Representative Sequence: AK093418
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255858 ENST00000321205 ENST00000320982 ENST00000381982 ENST00000540456(uc003aid.2 uc011akz.1 uc003aie.2)
    ENST00000392772(uc003aif.2)

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    hsa-miR-3119 hsa-miR-766
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    Additional cDNA sequence: 

    AK092002.1 AK093418.1 AK093448.1 AY158085.1 BC136358.1 BC136359.1 BC139912.1 CR456346.1 
    FJ824055.1 

    4 DOTS entries:

    DT.109027  DT.100020119  DT.120641042  DT.100751285 

    21 AceView cDNA sequences:

    AA813154 AY158085 NM_174977 CR456346 BX284067 AX747303 AK093448 BU584107 
    AK093418 BU584108 AX748114 AK092002 AA025930 T72380 BG740064 R12499 
    BX090813 AI016396 BU584106 AA025889 R09898 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
    SP1:              -                                 
    SP2:                                                


    ECgene alternative splicing isoforms for SEC14L4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC14L4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTGCATATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SEC14L4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SEC14L4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC14L4

    SOURCE GeneReport for Unigene cluster: Hs.517541
        SABiosciences Custom PCR Arrays for SEC14L4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC14L4 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SEC14L26
    Uncharacterized protein
    64(a)
    1 → many
    15(11138837-11143355)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    65(a)
    1 → many
    GL343417.1(136996-146283)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-89f7.16
    FP016199.16
    --
    59(a)
    51(a)
    many ↔ many
    many ↔ many
    5(14630172-14671653)
    11(21334779-21347504)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138936
    --
    31(a)
    possible ortholog
    3L(599094-604001)
    worm
    (Caenorhabditis elegans)
    Secernentea ctg-16
    CRAL/TRIO and GOLD domain containing family member...
    29(a)
    possible ortholog
    I(7005442-7009174)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G558406
    AT5G477306
    sec.4-like phosphatidylinositol transfer protein
    putative sec14p-like phosphatidylinositol transfer...
    22(a)
    19(a)
    many ↔ many
    many ↔ many
    1(20873602-20876272)
    5(19334250-19337101)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    CRAL/TRIO domain containing protein, expressed
    (see all 3)
    20(a)
    19(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    9(4348564-4354226)
    2(5604236-5609533)


    ENSEMBL Gene Tree for SEC14L4 (if available)
    TreeFam Gene Tree for SEC14L4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC14L4 gene
    ENSG000002495902  SEC14L12  SEC14L62  SEC14L22  SEC14L52  SEC14L32  
    7 SIMAP similar genes for SEC14L4 using alignment to 6 protein entries:     S14L4_HUMAN (see all proteins):
    SEC14L6    SEC14L3    SEC14L2    SEC14L1    DKFZp686C06176    SEC14L5
    Em

    SEC14L4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SEC14L4
    PGOHUM00000250323


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/416 NCBI SNPs in SEC14L4 are shown (see all 416    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs413046751,2
    --30884400(+) GATCAC/TGGCCC 2 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1512278891,2
    --30884401(+) ATCACA/GGCCCT 2 -- ds50010--------
    rs81387591,2
    C,F,A,H,--30884427(+) GGAAAC/TACTTG 2 -- ds500121Minor allele frequency- T:0.12NA NS EA WA 2366
    rs169887081,2
    C,F,H,--30884500(+) AATCGG/CCTGTA 2 -- ds50019Minor allele frequency- C:0.03NA NS EA WA 680
    rs1409109271,2
    --30884624(+) CAACCA/GGTGGG 2 -- ds50010--------
    rs1450000531,2
    --30884627(+) CCGGTA/GGGCCT 2 -- ds50010--------
    rs1847507361,2
    --30884658(+) CTCCCA/GGCTCC 2 -- ds50010--------
    rs1388362641,2
    --30884765(+) AACAGA/GGTAGT 2 -- ds50010--------
    rs96067351,2
    C,F,A,H,--30884831(+) TGTGAC/TTCTTG 2 -- ds500111Minor allele frequency- T:0.10NS EA NA WA 784
    rs96089401,2
    C,F,A,--30884870(+) CCAGCG/ACAGCC 2 -- ds50017Minor allele frequency- A:0.33WA NA CSA 247

    HapMap Linkage Disequilibrium report for SEC14L4 (30884889 - 30901698 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SEC14L4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC14L4
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC14L4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEC14L4 for disorders           About MalaCards

    SEC14L4 for disorders           About GeneDecksing

    OMIM gene information: 612825    OMIM disorders: --


    Export disorders for SEC14L4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC14L4 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SEC14L4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PubMed id 12757856)1, 2 Kempna P.... Azzi A. (2003)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Alternative splicing and gene polymorphism of the human TAP3/SEC14L4 gene. (PubMed id 20012369)1 Kempna P.... Zingg J.M. (2009)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    8. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284904 HGNC: 20627 AceView: SEC14L4 Ensembl:ENSG00000133488 euGenes: HUgn284904
    ECgene: SEC14L4 H-InvDB: SEC14L4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC14L4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC14L4 gene:
    Search GeneIP for patents involving SEC14L4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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