SEC14L3 Gene
protein-coding GIFtS: 50
GCID: GC22M030843
|
|
SEC14-like 3 (S. cerevisiae)
| |
Aliases
for SEC14L3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SEC14-Like 3 (S. Cerevisiae)1 2 | | TAP21 2 3 5 | | Tocopherol-Associated Protein 22 3 | | SEC14-Like Protein 32 | | SEC14p-Like Protein TAP22 |
Export aliases for SEC14L3 gene to outside databasesPrevious GC identifers: GC22U990252 GC22M027553 GC22M029180 GC22M029179 GC22M013816 |
Summaries
for SEC14L3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEC14L3:
The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene.The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derivedtransport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. Thespecific function of this protein has not yet been determined. Alternatively spliced transcript variants encodingmultiple isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)
UniProtKB/Swiss-Prot: S14L3_HUMAN, Q9UDX4Function: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands liketocopherol, squalene and phospholipids
|
Genomic Views
for SEC14L3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEC14L3 gene promoter:
HEN1 NF-1 AML1a NRSF form 1 RelA Pax-4a NRSF form 2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEC14L3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC14L3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC chromosome: 22SEC14L3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M030843: view genomic region
(about GC identifiers)
Start:
|
30,843,946 bp from pter |
End:
|
30,868,036 bp from pter |
Size:
|
24,091 bases |
Orientation:
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minus strand |
|
Proteins
for SEC14L3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S14L3_HUMAN, Q9UDX4 (See
protein sequence)Recommended Name: SEC14-like protein 3 Size: 400 amino acids; 46048 Da
Secondary accessions: E7EN74 E9PE57 Q495V8 Q495W0 Q495W1Alternative splicing: 3 isoforms: Q9UDX4-1 Q9UDX4-2 Q9UDX4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SEC14L3: NX_Q9UDX4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UDX4
SEC14L3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001244307.1 NP_001244308.1 NP_001244311.1 NP_777635.1
ENSEMBL proteins: ENSP00000385941 ENSP00000215812 ENSP00000385004 ENSP00000405055 ENSP00000383896 ENSP00000402986 ENSP00000401864 ENSP00000444691 ENSP00000439752
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SEC14L3 for ontologies About GeneDecksing
SEC14L3 Antibody Products:
Assay Products for SEC14L3: |
Protein
Domains /
Families
for SEC14L3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEC14L3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UDX4ProtoNet protein and cluster: Q9UDX4 3 Blocks protein families: IPB001071 Cellular retinaldehyde-binding protein signature IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) IPB008273 Cellular retinaldehyde-binding/triple function
UniProtKB/Swiss-Prot: S14L3_HUMAN, Q9UDX4Similarity: Contains 1 CRAL-TRIO domainSimilarity: Contains 1 GOLD domain |
Function
for SEC14L3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S14L3_HUMAN, Q9UDX4Function: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands liketocopherol, squalene and phospholipids
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC14L3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC14L3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SEC14L3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC14L3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- | | GO:0008289 | lipid binding |
IEA | -- |
SEC14L3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SEC14L3:
|
Pathways & Interactions
for SEC14L3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC14L3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
-- | -- |
SEC14L3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SEC14L3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEC14L3
1 HMDB Compound for SEC14L3 About this table
1 DrugBank Compound for SEC14L3 About this table
Search CenterWatch for drugs/clinical trials and news about SEC14L3 / S14L3
|
Transcripts
for SEC14L3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEC14L3 gene (4 alternative transcripts): NM_001257378.1 NM_001257379.1 NM_001257382.1 NM_174975.4 Unigene Cluster for SEC14L3: SEC14-like 3 (S. cerevisiae) Hs.505601 [show with all ESTs]Unigene Representative Sequence: AK1313589 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000403066 ENST00000215812(uc003ahy.3 uc003ahz.3 uc003aia.3 uc003aib.3)
ENST00000402286 ENST00000434642 ENST00000401751 ENST00000435069 ENST00000415957
ENST00000539629 ENST00000540910
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC14L3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC14L3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SEC14L3 (NM_174975) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEC14L3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC14L3 |
Additional cDNA sequence: AK131358.1 AK298079.1 AY158086.1 AY240872.1 BC069641.1 BC101001.2 BC101002.1 BC101003.1 BC101004.1 5 DOTS entries: DT.86837519 DT.86844316 DT.403868 DT.75136622 DT.40228318 17 AceView cDNA sequences: BE465278 BE550715 AY158086 BE348662 NM_174975 AW339509 BQ186227 AY240872 BE644691 BU584962 BC069641 AW291493 BU584931 AK131358 BE669543 BE219833 CD694547
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SEC14L3
|
Expression
for SEC14L3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEC14L3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCTGATAG
About this image
See SEC14L3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC14L3
SOURCE GeneReport for Unigene cluster: Hs.505601
SABiosciences Custom PCR Arrays for SEC14L3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC14L3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC14L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC14L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC14L3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L3 |
Orthologs
for SEC14L3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SEC14L3 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for SEC14L3 (if available)
TreeFam Gene Tree for SEC14L3 (if available) |
Paralogs
for SEC14L3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEC14L3 gene
- ENSG000002495902 SEC14L12 SEC14L62 SEC14L22 SEC14L52 SEC14L42
18/84 SIMAP similar genes for SEC14L3 using alignment to 6 protein entries: S14L3_HUMAN (see all proteins)
(see all similar genes):TCTEX1D2 TM4SF19 SEC14L2 SNRPF SEC14L4 FTSJ2
NDC80 UBXN4 SEC14L6 MSH5 C12orf76 IK
DOCK8 DYNC2LI1 GNB2L1 KIAA0101 LSM12 RHBG
SEC14L3 for paralogs About GeneDecksing
|
Genomic Variants
for SEC14L3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEC14L3 (30843946 - 30868036 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for SEC14L3
2 CNVs: 79545 91025
8 Indels: 91024 79547 91028 91027 79546 79549 91026 79548 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC14L3 |
|
Disorders
/ Diseases
for SEC14L3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SEC14L3 for disorders About GeneDecksing
OMIM gene information: 612824
OMIM disorders: --
1  disease for SEC14L3: About MalaCardssilicosis
1 disease from the University of Copenhagen DISEASES database for SEC14L3:Silicosis Export disorders for SEC14L3 gene to outside databases
|
Publications
for SEC14L3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEC14L3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SEC14L3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. (PubMed id 15040456)1, 7, 9 Ye X.... Mao Y. (2004)
- Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PubMed id 12757856)1, 2 Kempna P.... Azzi A. (2003)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
- How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A. (PubMed id 15033454)1 Mokashi V....Porter T.D. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- Recombinant SEC14-like proteins (TAP) possess GTPase activity. (PubMed id 15567179)9 Habermehl D....Zingg J.M. (2005)
|
External Searches for SEC14L3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SEC14L3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SEC14L3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SEC14L3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SEC14L3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SEC14L3 gene:
Search GeneIP for patents involving SEC14L3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SEC14L3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC14L3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC14L3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC14L3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC14L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC14L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC14L3 |
| |
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| |  |  |  |  | | | | |
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 | | | SEC14L3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L3 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC14L3 |
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