Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEC14L3 Gene

protein-coding   GIFtS: 51
GCID: GC22M030843

SEC14-Like 3 (S. Cerevisiae)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SEC14-Like 3 (S. Cerevisiae)1 2
TAP22 3 5
Tocopherol-Associated Protein 22 3
SEC14-Like Protein 32
SEC14p-Like Protein TAP22

External Ids:    HGNC: 186551   Entrez Gene: 2666292   Ensembl: ENSG000001000127   OMIM: 6128245   UniProtKB: Q9UDX43   

Export aliases for SEC14L3 gene to outside databases

Previous GC identifers: GC22U990252 GC22M027553 GC22M029180 GC22M029179 GC22M013816


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEC14L3 Gene:
The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14
gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of
Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi
complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for SEC14L3 Gene:
SEC14L3 (SEC14-like 3 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SEC14L3 include silicosis. GO annotations related to this gene include lipid binding and transporter activity. An important paralog of this gene is ENSG00000249590.

UniProtKB/Swiss-Prot: S14L3_HUMAN, Q9UDX4
Function: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands
like tocopherol, squalene and phospholipids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC14L3 gene promoter:
         HEN1   NF-1   AML1a   NRSF form 1   RelA   Pax-4a   NRSF form 2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC14L3 promoter sequence
   Search Chromatin IP Primers for SEC14L3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC14L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

SEC14L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC14L3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M030843:  view genomic region     (about GC identifiers)

Start:
30,843,946 bp from pter      End:
30,868,036 bp from pter
Size:
24,091 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S14L3_HUMAN, Q9UDX4 (See protein sequence)
Recommended Name: SEC14-like protein 3  
Size: 400 amino acids; 46048 Da
Secondary accessions: E7EN74 E9PE57 Q495V8 Q495W0 Q495W1
Alternative splicing: 3 isoforms:  Q9UDX4-1   Q9UDX4-2   Q9UDX4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC14L3: NX_Q9UDX4

Explore proteomics data for SEC14L3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SEC14L3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001244307.1  NP_001244308.1  NP_001244311.1  NP_777635.1  

    ENSEMBL proteins: 
     ENSP00000385941   ENSP00000215812   ENSP00000385004   ENSP00000405055   ENSP00000383896  
     ENSP00000402986   ENSP00000401864   ENSP00000444691   ENSP00000439752  

    SEC14L3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SEC14L3
    OriGene Protein Over-expression Lysate for SEC14L3
    OriGene MassSpec for SEC14L3
    OriGene Custom Protein Services for SEC14L3
    GenScript Custom Purified and Recombinant Proteins Services for SEC14L3
    Novus Biologicals SEC14L3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC14L3

    SEC14L3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEC14L3
    Novus Biologicals SEC14L3 Antibodies
    Search for Antibodies for SEC14L3 at Abcam
    Cloud-Clone Corp. Antibodies for SEC14L3
    Search ThermoFisher Antibodies for SEC14L3
    Search LSBio for Antibodies for SEC14L3

    SEC14L3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEC14L3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEC14L3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEC14L3
    Cloud-Clone Corp. CLIAs for SEC14L3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR001071 CRAL-bd_toc_tran
     IPR001251 CRAL-TRIO_dom
     IPR009038 GOLD
     IPR011074 CRAL/TRIO_N_dom

    Graphical View of Domain Structure for InterPro Entry Q9UDX4

    ProtoNet protein and cluster: Q9UDX4

    3 Blocks protein domains:
    IPB001071 Cellular retinaldehyde-binding protein signature
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
    IPB008273 Cellular retinaldehyde-binding/triple function


    UniProtKB/Swiss-Prot: S14L3_HUMAN, Q9UDX4
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 GOLD domain


    SEC14L3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S14L3_HUMAN, Q9UDX4
    Function: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands
    like tocopherol, squalene and phospholipids

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0008289lipid binding IEA--
         
    SEC14L3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SEC14L3:
     Decreased viability  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC14L3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC14L3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC14L3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC14L3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC14L3:
    hsa-mir-124-3p (MIRT022957), hsa-mir-335-5p (MIRT018600)

    Block miRNA regulation of human, mouse, rat SEC14L3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SEC14L3:
    hsa-miR-18a hsa-miR-593 hsa-miR-4251 hsa-miR-18b hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidSEC14L3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEC14L3
    Predesigned siRNA for gene silencing in human, mouse, rat SEC14L3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC14L3

    Clone
    Products:
         
    OriGene clones in human, mouse for SEC14L3 (see all 5)
    OriGene ORF clones in mouse, rat for SEC14L3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC14L3 (NM_174975)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC14L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC14L3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEC14L3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEC14L3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0016021integral component of membrane IEA--

    SEC14L3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC14L3
    Interactions:

        Search GeneGlobe Interaction Network for SEC14L3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC14L3 (ENSP000002158124) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOSPD2ENSP000003698604STRING: ENSP00000369860
    PFDN5ENSP000003341884STRING: ENSP00000334188
    TRAPPC6BENSP000003302894STRING: ENSP00000330289
    VBP1ENSP000002864284STRING: ENSP00000286428
    TREHENSP000002640294STRING: ENSP00000264029
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----

    SEC14L3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC14L3 (S14L3)

    1 HMDB Compound for SEC14L3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Squalene(E,E,E,E)-Squalene (see all 10)111-02-4--

    1 DrugBank Compound for SEC14L3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--15040456 17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEC14L3 gene (4 alternative transcripts): 
    NM_001257378.1  NM_001257379.1  NM_001257382.1  NM_174975.4  

    Unigene Cluster for SEC14L3:

    SEC14-like 3 (S. cerevisiae)
    Hs.505601  [show with all ESTs]
    Unigene Representative Sequence: AK131358
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403066 ENST00000215812(uc003ahy.3 uc003ahz.3 uc003aia.3 uc003aib.3)
    ENST00000402286 ENST00000434642 ENST00000401751 ENST00000435069 ENST00000415957
    ENST00000539629 ENST00000540910
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEC14L3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SEC14L3:
    hsa-miR-18a hsa-miR-593 hsa-miR-4251 hsa-miR-18b hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidSEC14L3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEC14L3
    Predesigned siRNA for gene silencing in human, mouse, rat SEC14L3
    Clone
    Products:
         
    OriGene clones in human, mouse for SEC14L3 (see all 5)
    OriGene ORF clones in mouse, rat for SEC14L3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC14L3 (NM_174975)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC14L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC14L3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC14L3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC14L3
      QuantiTect SYBR Green Assays in human, mouse, rat SEC14L3
      QuantiFast Probe-based Assays in human, mouse, rat SEC14L3

    Additional mRNA sequence: 

    AK131358.1 AK298079.1 AY158086.1 AY240872.1 BC069641.1 BC101001.2 BC101002.1 BC101003.1 
    BC101004.1 

    5 DOTS entries:

    DT.86837519  DT.86844316  DT.403868  DT.75136622  DT.40228318 

    17 AceView cDNA sequences:

    BE550715 BE465278 AY158086 NM_174975 BE348662 BE669543 BU584931 AK131358 
    BC069641 BU584962 BQ186227 AY240872 BE644691 AW291493 AW339509 BE219833 
    CD694547 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -                                                                                       
    SP2:                                            -                                                         
    SP3:              -                             -                                                         
    SP4:              -     -                       -                                                         


    ECgene alternative splicing isoforms for SEC14L3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEC14L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCTGATAG
    SEC14L3 Expression
    About this image

    SEC14L3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC14L3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505601
        Custom PCR Arrays for SEC14L3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC14L3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC14L3
    QuantiTect SYBR Green Assays in human, mouse, rat SEC14L3
    QuantiFast Probe-based Assays in human, mouse, rat SEC14L3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC14L3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec14l31 , 5 SEC14-like 3 (S. cerevisiae)1, 5 90.58(n)1
    97(a)1
      11 (2.86 cM)5
    3806831  NM_001029937.21  NP_001025108.11 
     40648415 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    59(a)
    1 → many
    15(10804520-10813425)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    GL343417.1(136904-146295)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-89f7.16
    FP016199.16
    Uncharacterized protein
    67(a)
    55(a)
    many ↔ many
    many ↔ many
    5(14630172-14671653) ENSDARG00000059729
    11(21334779-21347504) ENSDARG00000074570
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138936
    --
    29(a)
    1 → many
    3L(599094-604001)
    worm
    (Caenorhabditis elegans)
    Secernentea ctg-16
    ctg-26
    (see all 8)
    Protein CTG-1, isoform c (ctg-1) mRNA, complete cd...
    Protein CTG-2, isoform b (ctg-2) mRNA, complete cd...
    (see all 8)
    27(a)
    24(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    I(7005443-7009175) WBGene00010370
    II(8514826-8517106) WBGene00011756
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC146
    --
    Phosphatidylinositol/phosphatidylcholine transfer ...
    Putative homolog of Sec14p, which is a phosphatidy...
    27(a)
    25(a)
    many ↔ many
    many ↔ many
    XIII(424989-426059) YMR079W
    XI(269718-270650) YKL091C


    ENSEMBL Gene Tree for SEC14L3 (if available)
    TreeFam Gene Tree for SEC14L3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEC14L3 gene
    ENSG000002495902  SEC14L12  SEC14L62  SEC14L52  SEC14L22  SEC14L42  
    Selected SIMAP similar genes for SEC14L3 using alignment to 6 protein entries:     S14L3_HUMAN (see all proteins) (see all similar genes):
    TCTEX1D2    TM4SF19    SEC14L2    SNRPF    SEC14L4    FTSJ2
    NDC80    UBXN4    SEC14L6    C12orf76    IK    ZNF85
    DOCK8    DYNC2LI1    GNB2L1    LSM12    RHBG    ZNF66

    SEC14L3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEC14L3 (see all 429)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58449101,2
    C,F--13823928(+) AAGTA-/TCCCTA 4 -- int14Minor allele frequency- T:0.17NA CSA 12
    rs351099291,2
    C--13825514(+) AAAAAG/-GAGGG 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs1116166001,2
    C--13825515(+) AAAAAA/GAGGGT 4 -- int11Minor allele frequency- G:0.00CSA 1
    rs104278431,2
    C,A,H--13825516(+) AAAAGG/AGGGTT 4 -- int1 trp32Minor allele frequency- A:0.33NA CSA 3
    rs2003107851,2
    --13825516(+) AAAAG-/AGGGTT 4 -- int10--------
    rs48208551,2
    A--13826539(+) aaaaaA/Gaaaaa 4 -- int1 trp30--------
    rs1131320411,2
    C--13826539(+) AAAAAG/-AAAAA 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs1470751971,2
    C--14777210(+) TCCCAA/GCACTT 4 -- ds5001 int10--------
    rs96209931,2
    H--14777223(+) ggaggC/Ttgatg 4 -- ds5001 int15Minor allele frequency- T:0.00NS EA NA 422
    rs764216161,2
    C--14777227(+) CTGAT-/GGGGGG 4 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for SEC14L3 (30843946 - 30868036 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SEC14L3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829171CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC14L3
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC14L3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612824    OMIM disorders: --

    1 disease for SEC14L3:    
    About MalaCards
    silicosis

    1 disease from the University of Copenhagen DISEASES database for SEC14L3:
    Silicosis

    SEC14L3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEC14L3

    Export disorders for SEC14L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEC14L3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SEC14L3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. (PubMed id 15040456)1, 7, 9 Ye X.... Mao Y. (Mol. Biol. Rep. 2004)
    2. Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PubMed id 12757856)1, 2 Kempna P.... Azzi A. (Free Radic. Biol. Med. 2003)
    3. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    4. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    5. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A. (PubMed id 15033454)1 Mokashi V....Porter T.D. (Biochem. Biophys. Res. Commun. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    10. Recombinant SEC14-like proteins (TAP) possess GTPase activity. (PubMed id 15567179)9 Habermehl D....Zingg J.M. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 266629 HGNC: 18655 AceView: SEC14L3 Ensembl:ENSG00000100012 euGenes: HUgn266629
    ECgene: SEC14L3 H-InvDB: SEC14L3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEC14L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEC14L3 gene:
    Search GeneIP for patents involving SEC14L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEC14L3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SEC14L3  
     OriGene MassSpec something-or-other for SEC14L3   OriGene clones in human, mouse for SEC14L3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEC14L3   OriGene Purified Protein for SEC14L3  
     OriGene ORF clones in mouse, rat for SEC14L3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEC14L3   OriGene Custom Protein Services for SEC14L3  

     
     
     Block miRNA regulation of human, mouse, rat SEC14L3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEC14L3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC14L3 Predesigned siRNA for gene silencing in human, mouse, rat SEC14L3
     QuantiFast Probe-based Assays in human, mouse, rat SEC14L3 QuantiTect SYBR Green Assays in human, mouse, rat SEC14L3
     Custom PCR Arrays for SEC14L3 Search Chromatin IP Primers for SEC14L3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC14L3  Search GeneGlobe Interaction Network for SEC14L3
     Regulatory tfbs in SEC14L3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEC14L3 GenScript cDNA clones with any tag delivered in your preferred vector for SEC14L3
     GenScript Custom Assay Services for SEC14L3 GenScript Custom overexpressing Cell Line Services for SEC14L3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEC14L3 (S14L3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEC14L3 antibodies
     SEC14L3 lysates
     Search for Antibodies for SEC14L3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SEC14L3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SEC14L3
     Antibodies for SEC14L3
     ELISAs for SEC14L3
     CLIAs for SEC14L3



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEC14L3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L3
     SwitchGear 3'UTR luciferase reporter plasmids for SEC14L3
     SwitchGear Promoter luciferase reporter plasmids for SEC14L3
     Search ThermoFisher Antibodies for SEC14L3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC14L3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC14L3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC14L3
     Search LSBio for Antibodies for SEC14L3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEC14L3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4