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Aliases for SEC14L3 Gene

Aliases for SEC14L3 Gene

  • SEC14-Like 3 (S. Cerevisiae) 2 3
  • TAP2 3 4 6
  • Tocopherol-Associated Protein 2 3 4
  • SEC14p-Like Protein TAP2 3
  • SEC14-Like Protein 3 3

External Ids for SEC14L3 Gene

Previous GeneCards Identifiers for SEC14L3 Gene

  • GC22U990252
  • GC22M027553
  • GC22M029180
  • GC22M029179
  • GC22M030843
  • GC22M013816

Summaries for SEC14L3 Gene

Entrez Gene Summary for SEC14L3 Gene

  • The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for SEC14L3 Gene

SEC14L3 (SEC14-Like 3 (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is SEC14L6.

UniProtKB/Swiss-Prot for SEC14L3 Gene

  • Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L3 Gene

Genomics for SEC14L3 Gene

Regulatory Elements for SEC14L3 Gene

Genomic Location for SEC14L3 Gene

Start:
30,447,959 bp from pter
End:
30,472,049 bp from pter
Size:
24,091 bases
Orientation:
Minus strand

Genomic View for SEC14L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC14L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L3 Gene

Proteins for SEC14L3 Gene

  • Protein details for SEC14L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDX4-S14L3_HUMAN
    Recommended name:
    SEC14-like protein 3
    Protein Accession:
    Q9UDX4
    Secondary Accessions:
    • E7EN74
    • E9PE57
    • Q495V8
    • Q495W0
    • Q495W1

    Protein attributes for SEC14L3 Gene

    Size:
    400 amino acids
    Molecular mass:
    46048 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SEC14L3 Gene

    Alternative splice isoforms for SEC14L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC14L3 Gene

Proteomics data for SEC14L3 Gene at MOPED

Post-translational modifications for SEC14L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SEC14L3 Gene

Domains for SEC14L3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UDX4

UniProtKB/Swiss-Prot:

S14L3_HUMAN :
  • Q9UDX4
Domain:
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 GOLD domain.
genes like me logo Genes that share domains with SEC14L3: view

No data available for Gene Families for SEC14L3 Gene

Function for SEC14L3 Gene

Molecular function for SEC14L3 Gene

UniProtKB/Swiss-Prot Function:
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids

Gene Ontology (GO) - Molecular Function for SEC14L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with SEC14L3: view

Phenotypes for SEC14L3 Gene

GenomeRNAi human phenotypes for SEC14L3:
genes like me logo Genes that share phenotypes with SEC14L3: view

Animal Model Products

CRISPR Products

miRNA for SEC14L3 Gene

miRTarBase miRNAs that target SEC14L3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC14L3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC14L3 Gene

Localization for SEC14L3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC14L3 Gene COMPARTMENTS Subcellular localization image for SEC14L3 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEC14L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SEC14L3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEC14L3 Gene

Pathways for SEC14L3 Gene

genes like me logo Genes that share pathways with SEC14L3: view

Interacting Proteins for SEC14L3 Gene

Gene Ontology (GO) - Biological Process for SEC14L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SEC14L3: view

Compounds for SEC14L3 Gene

(1) HMDB Compounds for SEC14L3 Gene

Compound Synonyms Cas Number PubMed IDs
Squalene
  • (E,E,E,E)-Squalene
111-02-4

(1) Drugbank Compounds for SEC14L3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin E
  • alpha-Tocopherol
59-02-9 target
genes like me logo Genes that share compounds with SEC14L3: view

Transcripts for SEC14L3 Gene

Unigene Clusters for SEC14L3 Gene

SEC14-like 3 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC14L3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3: - -
SP4: - - -

Relevant External Links for SEC14L3 Gene

GeneLoc Exon Structure for
SEC14L3
ECgene alternative splicing isoforms for
SEC14L3

Expression for SEC14L3 Gene

mRNA expression in normal human tissues for SEC14L3 Gene

mRNA differential expression in normal tissues according to GTEx for SEC14L3 Gene

This gene is overexpressed in Liver (26.9), Lung (6.2), and Testis (4.1).

Protein differential expression in normal tissues for SEC14L3 Gene

This gene is overexpressed in Heart (39.6), Brain (12.5), Gallbladder (8.9), and Retina (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEC14L3 Gene

SOURCE GeneReport for Unigene cluster for SEC14L3 Gene Hs.505601

genes like me logo Genes that share expressions with SEC14L3: view

Expression partners for SEC14L3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SEC14L3 Gene

Orthologs for SEC14L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC14L3 35
  • 91.42 (n)
  • 96 (a)
SEC14L3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC14L3 35
  • 91.25 (n)
  • 97.75 (a)
SEC14L3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec14l3 35
  • 90.58 (n)
  • 97 (a)
Sec14l3 16
Sec14l3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC14L3 35
  • 99.25 (n)
  • 98.75 (a)
SEC14L3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec14l3 35
  • 90.25 (n)
  • 96.5 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC14L3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC14L3 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FP016199.1 36
  • 55 (a)
ManyToMany
si:ch211-89f7.1 36
  • 67 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13893 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cgr-1 36
  • 23 (a)
ManyToMany
ctg-1 36
  • 27 (a)
ManyToMany
ctg-2 36
  • 24 (a)
ManyToMany
F18A11.2 36
  • 19 (a)
ManyToMany
F20G2.3 36
  • 20 (a)
ManyToMany
F28H7.8 36
  • 22 (a)
ManyToMany
H41C03.1 36
  • 23 (a)
ManyToMany
R03A10.5 36
  • 20 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 25 (a)
ManyToMany
SEC14 36
  • 27 (a)
ManyToMany
Species with no ortholog for SEC14L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SEC14L3 Gene

ENSEMBL:
Gene Tree for SEC14L3 (if available)
TreeFam:
Gene Tree for SEC14L3 (if available)

Paralogs for SEC14L3 Gene

Paralogs for SEC14L3 Gene

genes like me logo Genes that share paralogs with SEC14L3: view

Variants for SEC14L3 Gene

Sequence variations from dbSNP and Humsavar for SEC14L3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs714456 -- 30,472,431(-) ACCCT(G/T)TCAGA upstream-variant-2KB
rs757661 -- 30,454,727(+) ataat(A/C)tataa intron-variant
rs757662 -- 30,466,644(+) CTGTT(G/T)ATTAA intron-variant
rs757663 -- 30,466,776(+) TGGAA(C/T)GTGTG intron-variant
rs1047917 -- 30,466,159(+) CCAAC(A/C)CTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L3 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138

Relevant External Links for SEC14L3 Gene

HapMap Linkage Disequilibrium report
SEC14L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L3 Gene

Disorders for SEC14L3 Gene

(1) University of Copenhagen DISEASES for SEC14L3 Gene

Relevant External Links for SEC14L3

Genetic Association Database (GAD)
SEC14L3
genes like me logo Genes that share disorders with SEC14L3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SEC14L3 Gene

Publications for SEC14L3 Gene

  1. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. (PMID: 15040456) Ye X. … Mao Y. (Mol. Biol. Rep. 2004) 3 23 25
  2. Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. (PMID: 12757856) Kempna P. … Azzi A. (Free Radic. Biol. Med. 2003) 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A. (PMID: 15033454) Mokashi V. … Porter T.D. (Biochem. Biophys. Res. Commun. 2004) 3

Products for SEC14L3 Gene

Sources for SEC14L3 Gene

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