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SEC14L2 Gene

protein-coding   GIFtS: 59
GCID: GC22P030792

SEC14-Like 2 (S. Cerevisiae)

(Previous name: SEC14 (S. cerevisiae)-like 2)
(Previous symbol: C22orf6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SEC14-Like 2 (S. Cerevisiae)1 2     KIAA11863 5
C22orf61 2 3     SEC14 (S. Cerevisiae)-Like 21
Supernatant Protein Factor1 2 3     TAP12
TAP2 3 5     SEC14-Like Protein 22
Alpha-Tocopherol-Associated Protein2 3     Tocopherol-Associated Protein2
Squalene Transfer Protein2 3     KIAA16583
SPF2 3     hTAP3

External Ids:    HGNC: 106991   Entrez Gene: 235412   Ensembl: ENSG000001000037   OMIM: 6075585   UniProtKB: O760543   

Export aliases for SEC14L2 gene to outside databases

Previous GC identifers: GC22P027488 GC22P029117 GC22P013754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEC14L2 Gene:
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p,
alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene
monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced
transcript variants encoding different isoforms have been identified for this gene. (provided by RefSeq, Oct
2008)

GeneCards Summary for SEC14L2 Gene:
SEC14L2 (SEC14-like 2 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and vitamin E binding. An important paralog of this gene is ENSG00000249590.

UniProtKB/Swiss-Prot: S14L2_HUMAN, O76054
Function: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different
cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other
tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with
alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate
cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell

Gene Wiki entry for SEC14L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC14L2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC14L2 promoter sequence
   Search Chromatin IP Primers for SEC14L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC14L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

SEC14L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC14L2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P030792:  view genomic region     (about GC identifiers)

Start:
30,792,846 bp from pter      End:
30,821,305 bp from pter
Size:
28,460 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S14L2_HUMAN, O76054 (See protein sequence)
Recommended Name: SEC14-like protein 2  
Size: 403 amino acids; 46145 Da
Subunit: Monomer (By similarity)
Developmental stage: Low expression in fetal tissues
Sequence caution: Sequence=BAA86500.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for SEC14L2:
1O6U (3D)        1OLM (3D)    
Secondary accessions: B7Z8Q1 F5H3U4 Q53EQ2 Q6PD61 Q9ULN4
Alternative splicing: 3 isoforms:  O76054-1   O76054-4   O76054-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC14L2: NX_O76054

Explore proteomics data for SEC14L2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys196
  • Modification sites at PhosphoSitePlus

  • See SEC14L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001191133.1  NP_036561.1  NP_203740.1  

    ENSEMBL proteins: 
     ENSP00000316203   ENSP00000387781   ENSP00000383993   ENSP00000388719   ENSP00000388888  
     ENSP00000385186   ENSP00000407857   ENSP00000399596   ENSP00000383882  

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    Novus Biologicals SEC14L2 Proteins
    Novus Biologicals SEC14L2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SEC14L2 

     
    antibodies-online proteins for SEC14L2 (8 products) 

     
    antibodies-online peptides for SEC14L2

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    antibodies-online antibodies for SEC14L2 (35 products) 

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    antibodies-online kits for SEC14L2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001071 CRAL-bd_toc_tran
     IPR001251 CRAL-TRIO_dom
     IPR009038 GOLD
     IPR011074 CRAL/TRIO_N_dom

    Graphical View of Domain Structure for InterPro Entry O76054

    ProtoNet protein and cluster: O76054

    3 Blocks protein domains:
    IPB001071 Cellular retinaldehyde-binding protein signature
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
    IPB008273 Cellular retinaldehyde-binding/triple function


    UniProtKB/Swiss-Prot: S14L2_HUMAN, O76054
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 GOLD domain


    Find genes that share domains with SEC14L2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S14L2_HUMAN, O76054
    Function: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different
    cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other
    tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with
    alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate
    cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell

         Genatlas biochemistry entry for SEC14L2:
    yeast (S cerevisiae) SEC14-like 2,widely expressed

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005543phospholipid binding NAS7364757
    GO:0008431vitamin E binding NAS10829015
         
    Find genes that share ontologies with SEC14L2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SEC14L2:
     Increased G2M DNA content, inc 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sec14l2):
     homeostasis/metabolism 

    Find genes that share phenotypes with SEC14L2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sec14l2tm1Arai for SEC14L2

       genOway: Develop your customized and physiologically relevant rodent model for SEC14L2

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    hsa-mir-346 (MIRT006669)

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    Selected qRT-PCR Assays for microRNAs that regulate SEC14L2 (see all 23):
    hsa-miR-3685 hsa-miR-30c hsa-miR-631 hsa-miR-1271 hsa-miR-30d hsa-miR-3661 hsa-miR-766 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSEC14L2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S14L2_HUMAN, O76054: Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence
    of alpha-tocopherol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS11444841
    GO:0005737cytoplasm NAS10829015
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SEC14L2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC14L2
    Interactions:

        GeneGlobe Interaction Network for SEC14L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC14L2 (O760543 ENSP000003162034) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3CGP487363, ENSP000003521214I2D: score=1 STRING: ENSP00000352121
    MOSPD2ENSP000003698604STRING: ENSP00000369860
    PFDN5ENSP000003341884STRING: ENSP00000334188
    TRAPPC6BENSP000003302894STRING: ENSP00000330289
    VBP1ENSP000002864284STRING: ENSP00000286428
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006810transport ----
    GO:0045540regulation of cholesterol biosynthetic process NAS11226224
    GO:0045893positive regulation of transcription, DNA-templated NAS11444841

    Find genes that share ontologies with SEC14L2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC14L2 (S14L2)

    2 DrugBank Compounds for SEC14L2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3target--17139284 17016423
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17252538 16579965

    Selected Novoseek inferred chemical compound relationships for SEC14L2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    squalene 83.8 21 11226224 (4), 12454003 (3), 12559471 (2), 15680919 (1) (see all 9)
    tocopherol 82.9 15 12559471 (3), 10829015 (2), 11444841 (1), 17252538 (1) (see all 9)
    alpha tocopherol 77.9 49 11444841 (4), 12559471 (4), 19190344 (2), 12767229 (2) (see all 16)
    lanosterol 74.7 5 11226224 (1), 12559471 (1), 15040456 (1), 15753133 (1)
    vitamin-e 66.6 12 16267002 (3), 19190344 (1), 12972248 (1), 15814460 (1) (see all 5)
    25-hydroxyvitamin d 36.6 2 8968701 (1), 11127208 (1)
    cholesterol 28 32 15680919 (8), 11226224 (4), 12972248 (3), 12559471 (3) (see all 7)
    phosphatidylinositol 26.2 4 12767229 (2), 12429094 (1)
    lipid 16.8 3 12767229 (1), 12429094 (1)
    atp 0 6 12454003 (3), 17252538 (1)



    Find genes that share compounds with SEC14L2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEC14L2 gene (3 alternative transcripts): 
    NM_001204204.1  NM_012429.3  NM_033382.2  

    Unigene Cluster for SEC14L2:

    SEC14-like 2 (S. cerevisiae)
    Hs.335614  [show with all ESTs]
    Unigene Representative Sequence: NM_012429
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312932(uc003ahr.3 uc011aky.2 uc011akx.2 uc003ahs.3 uc003aht.3 uc010gvv.3)
    ENST00000428195 ENST00000403484 ENST00000467218 ENST00000416523 ENST00000437022
    ENST00000452649 ENST00000405717(uc003ahq.3) ENST00000459728 ENST00000429917
    ENST00000415072 ENST00000485482 ENST00000484486 ENST00000464335 ENST00000483116
    ENST00000478762 ENST00000402592(uc003ahu.3)
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    hsa-miR-3685 hsa-miR-30c hsa-miR-631 hsa-miR-1271 hsa-miR-30d hsa-miR-3661 hsa-miR-766 hsa-miR-30a
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    Additional mRNA sequence: 

    AB033012.2 AK056163.1 AK091402.1 AK092576.1 AK223587.1 AK296540.1 AK303751.1 AK314390.1 
    AL096881.1 AY203959.1 AY927429.1 AY927430.1 AY927434.1 AY927435.1 AY927436.1 AY927437.1 
    AY927438.1 AY927439.1 AY927441.1 BC048337.1 BC058915.1 CR456571.1 

    Selected DOTS entries (see all 25):

    DT.100728352  DT.445968  DT.91648524  DT.40242710  DT.95371481  DT.95371482  DT.120634076  DT.92014051 
    DT.401358  DT.120634059  DT.95135743  DT.40259941  DT.120634067  DT.100786798  DT.120633969  DT.120633977 
    DT.120634004  DT.120634096  DT.95237664  DT.120633972  DT.120633997  DT.40259922  DT.95371483  DT.100671004 

    Selected AceView cDNA sequences (see all 205):

    BM699779 BP350381 BX091297 BQ940934 AL096881 AA610131 AI202053 BU737593 
    R50869 BC058915 BM842564 H55520 BM705532 CR456571 BM708135 BM678036 
    BU584483 NM_012429 CB850890 AA626379 R49914 BC048337 BQ007531 BQ773720 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                                                                                -                                 
    SP2:                                      -     -     -                                                               
    SP3:                                      -                                                                           
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for SEC14L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEC14L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGACTGGCA
    SEC14L2 Expression
    About this image


    SEC14L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
     
     Liver (Hepatobiliary System)
    SEC14L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC14L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335614

    UniProtKB/Swiss-Prot: S14L2_HUMAN, O76054
    Tissue specificity: Widely expressed. Strong expression in liver, brain and prostate

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC14L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEC14L2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec14l21 , 5 SEC14-like 2 (S. cerevisiae)1, 5 88.75(n)1
    93.3(a)1
      11 (2.87 cM)5
    678151  NM_144520.21  NP_653103.11 
     40970395 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    65(a)
    1 → many
    15(10804520-10813425)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    70(a)
    1 → many
    GL343417.1(136904-146295)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX759336.12   -- 78.65(n)    BX759336.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-89f7.11 si:ch211-89f7.1 69.99(n)
    67.52(a)
      558964  NM_001099993.2  NP_001093463.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138933   -- 31(a)   61C6   --
    worm
    (Caenorhabditis elegans)
    Secernentea H06O01.33
    ctg-11
    retinal-binding protein like3
    ctg-11
    30(a)
    (best of 2)3
    44.13(n)1
    30.73(a)1
      I(7013786-7017132)3
    1724311  NM_059592.51  NP_491993.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC141 SEC14 44.87(n)
    31.22(a)
      855103   NP_013796.1 


    ENSEMBL Gene Tree for SEC14L2 (if available)
    TreeFam Gene Tree for SEC14L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEC14L2 gene
    ENSG000002495902  SEC14L12  SEC14L62  SEC14L52  SEC14L32  SEC14L42  
    7 SIMAP similar genes for SEC14L2 using alignment to 7 protein entries:     S14L2_HUMAN (see all proteins):
    SEC14L3    SEC14L4    SEC14L6    SEC14L1    DKFZp686C06176    SEC14L5
    Em

    Find genes that share paralogs with SEC14L2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEC14L2 (see all 592)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898081541,2
    --30790957(+) AAGGGA/CAGGCC 3 -- us2k10--------
    rs1173410841,2
    F--30791010(+) AGATGC/TGGGGA 3 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1401397251,2
    --30791242(+) AAGTGA/TCAAGC 3 -- us2k10--------
    rs1814160391,2
    --30791335(+) TGTTTG/TTTTTT 3 -- us2k10--------
    rs1503172811,2
    C--30791382(+) GTACAA/CTGGTG 3 -- us2k10--------
    rs1859994151,2
    --30791514(+) AGAGAC/TGGGGT 3 -- us2k10--------
    rs1379995621,2
    --30791617(+) CACCGC/TGCCCG 3 -- us2k10--------
    rs1881780661,2
    --30791758(+) CCCCAA/GGCCAG 3 -- us2k10--------
    rs10762711,2
    C,F,H--30791827(-) TGAGGC/TCCCCA 3 -- us2k119Minor allele frequency- T:0.15NA EA NS WA 1218
    rs1435901451,2
    --30791867(+) CTATGA/GAGGGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEC14L2 (30792846 - 30821305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SEC14L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829171CNV Loss20364138
    nsv914970CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC14L2
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC14L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607558    OMIM disorders: --


    Find genes that share disorders with SEC14L2           About GenesLikeMe

    3 Novoseek inferred disease relationships for SEC14L2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 30 19 16267002 (5), 19190344 (4), 17334589 (3)
    tumors 0 3 16267002 (3)
    cancer 0 1 16267002 (1)

    Genetic Association Database (GAD): SEC14L2
    Human Genome Epidemiology (HuGE) Navigator: SEC14L2 (5 documents)

    Export disorders for SEC14L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEC14L2 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with SEC14L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. (PubMed id 11226224)1, 2, 9 Shibata N.... Arai H. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    3. A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. (PubMed id 10829015)1, 2, 9 Zimmer S....Azzi A. (J. Biol. Chem. 2000)
    4. Crystal structure of the human supernatant protein factor. (PubMed id 12429094)1, 2, 9 Stocker A.... Baumann U. (Structure 2002)
    5. Tocopherol-associated protein is a ligand-dependent transcriptional activator. (PubMed id 11444841)1, 2, 9 Yamauchi J.... Esashi T. (Biochem. Biophys. Res. Commun. 2001)
    6. Association of variants in two vitamin e transport genes with circulating vitamin e concentrations and prostate cancer risk. (PubMed id 19190344)1, 4, 9 Wright M.E....Albanes D. (Cancer Res. 2009)
    7. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    8. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    9. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    10. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23541 HGNC: 10699 AceView: SEC14L2 Ensembl:ENSG00000100003 euGenes: HUgn23541
    ECgene: SEC14L2 H-InvDB: SEC14L2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1186 KIAA1658

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SEC14L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SEC14L2 gene:
    Search GeneIP for patents involving SEC14L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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