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Aliases for SEC14L2 Gene

Aliases for SEC14L2 Gene

  • SEC14-Like Lipid Binding 2 2 3
  • Supernatant Protein Factor 2 3 4
  • Alpha-Tocopherol-Associated Protein 3 4
  • Squalene Transfer Protein 3 4
  • C22orf6 3 4
  • TAP 3 4
  • SPF 3 4
  • Tocopherol-Associated Protein 1 2
  • Tocopherol-Associated Protein 3
  • SEC14 (S. Cerevisiae)-Like 2 2
  • SEC14-Like 2 (S. Cerevisiae) 2
  • KIAA1186 4
  • KIAA1658 4
  • TAP1 3
  • HTAP 4

External Ids for SEC14L2 Gene

Previous HGNC Symbols for SEC14L2 Gene

  • C22orf6

Previous GeneCards Identifiers for SEC14L2 Gene

  • GC22P027488
  • GC22P029117
  • GC22P030792
  • GC22P013754

Summaries for SEC14L2 Gene

Entrez Gene Summary for SEC14L2 Gene

  • This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for SEC14L2 Gene

SEC14L2 (SEC14-Like Lipid Binding 2) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include transporter activity and vitamin E binding. An important paralog of this gene is SEC14L6.

UniProtKB/Swiss-Prot for SEC14L2 Gene

  • Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell

Gene Wiki entry for SEC14L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L2 Gene

Genomics for SEC14L2 Gene

Regulatory Elements for SEC14L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC14L2 Gene

Chromosome:
22
Start:
30,396,857 bp from pter
End:
30,425,317 bp from pter
Size:
28,461 bases
Orientation:
Plus strand

Genomic View for SEC14L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC14L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L2 Gene

Proteins for SEC14L2 Gene

  • Protein details for SEC14L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76054-S14L2_HUMAN
    Recommended name:
    SEC14-like protein 2
    Protein Accession:
    O76054
    Secondary Accessions:
    • B7Z8Q1
    • F5H3U4
    • Q53EQ2
    • Q6PD61
    • Q9ULN4

    Protein attributes for SEC14L2 Gene

    Size:
    403 amino acids
    Molecular mass:
    46145 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=BAA86500.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEC14L2 Gene

    Alternative splice isoforms for SEC14L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC14L2 Gene

Proteomics data for SEC14L2 Gene at MOPED

Post-translational modifications for SEC14L2 Gene

  • Ubiquitination at Lys 196
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEC14L2 Gene

Domains & Families for SEC14L2 Gene

Gene Families for SEC14L2 Gene

Graphical View of Domain Structure for InterPro Entry

O76054

UniProtKB/Swiss-Prot:

S14L2_HUMAN :
  • Contains 1 CRAL-TRIO domain.
Domain:
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 GOLD domain.
genes like me logo Genes that share domains with SEC14L2: view

Function for SEC14L2 Gene

Molecular function for SEC14L2 Gene

GENATLAS Biochemistry:
yeast (S cerevisiae) SEC14-like 2,widely expressed
UniProtKB/Swiss-Prot Function:
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell

Gene Ontology (GO) - Molecular Function for SEC14L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005543 phospholipid binding NAS 7364757
GO:0008047 enzyme activator activity IEA --
GO:0008431 vitamin E binding NAS 10829015
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups IEA --
genes like me logo Genes that share ontologies with SEC14L2: view

Phenotypes for SEC14L2 Gene

genes like me logo Genes that share phenotypes with SEC14L2: view

Animal Models for SEC14L2 Gene

MGI Knock Outs for SEC14L2:

Animal Model Products

CRISPR Products

miRNA for SEC14L2 Gene

miRTarBase miRNAs that target SEC14L2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC14L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SEC14L2 Gene

Localization for SEC14L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC14L2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC14L2 Gene COMPARTMENTS Subcellular localization image for SEC14L2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SEC14L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus NAS 11444841
GO:0005737 cytoplasm NAS 10829015
GO:0005829 cytosol IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC14L2: view

Pathways & Interactions for SEC14L2 Gene

genes like me logo Genes that share pathways with SEC14L2: view

Interacting Proteins for SEC14L2 Gene

Selected Interacting proteins: O76054-S14L2_HUMAN for SEC14L2 Gene via I2D

Symbol External ID(s) Details
PIK3CG

Gene Ontology (GO) - Biological Process for SEC14L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006810 transport IEA --
GO:0008152 metabolic process --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0045540 regulation of cholesterol biosynthetic process NAS 11226224
genes like me logo Genes that share ontologies with SEC14L2: view

No data available for SIGNOR curated interactions for SEC14L2 Gene

Drugs & Compounds for SEC14L2 Gene

(8) Drugs for SEC14L2 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved Nutra Target 350,355
Palmitic Acid Experimental Pharma Full agonist, Agonist, Target 20
cholesterol Experimental Pharma Agonist 0
Lanosterin Experimental Pharma 0
ATP Pharma Activator 0

(6) Additional Compounds for SEC14L2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
25-hydroxyvitamin d
alpha tocopherol
LIPID
Phosphatidylinositol
squalene
  • (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-Tetracosahexaene
  • (E,E,E,E)-Squalene
  • 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • All-trans-Squalene
  • Nikko Squalane EX
111-02-4
genes like me logo Genes that share compounds with SEC14L2: view

Transcripts for SEC14L2 Gene

Unigene Clusters for SEC14L2 Gene

SEC14-like 2 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC14L2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: - - - -
SP7: - -
SP8: - - - - -

Relevant External Links for SEC14L2 Gene

GeneLoc Exon Structure for
SEC14L2
ECgene alternative splicing isoforms for
SEC14L2

Expression for SEC14L2 Gene

mRNA expression in normal human tissues for SEC14L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEC14L2 Gene

This gene is overexpressed in Liver (x11.1).

Protein differential expression in normal tissues from HIPED for SEC14L2 Gene

This gene is overexpressed in Liver (18.5), Liver, secretome (17.0), and Retina (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SEC14L2 Gene



SOURCE GeneReport for Unigene cluster for SEC14L2 Gene Hs.335614

mRNA Expression by UniProt/SwissProt for SEC14L2 Gene

O76054-S14L2_HUMAN
Tissue specificity: Widely expressed. Strong expression in liver, brain and prostate.
genes like me logo Genes that share expression patterns with SEC14L2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SEC14L2 Gene

Orthologs for SEC14L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC14L2 36
  • 99 (a)
OneToOne
SEC14L2 35
  • 99.5 (n)
  • 99.26 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Sec14l2 36
  • 93 (a)
OneToOne
Sec14l2 16
Sec14l2 35
  • 88.75 (n)
  • 93.3 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SEC14L2 36
  • 91 (a)
OneToOne
SEC14L2 35
  • 92.06 (n)
  • 92.56 (a)
cow
(Bos Taurus)
Mammalia SEC14L2 36
  • 91 (a)
OneToOne
SEC14L2 35
  • 89.41 (n)
  • 90.82 (a)
rat
(Rattus norvegicus)
Mammalia Sec14l2 35
  • 89.58 (n)
  • 93.8 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sec14l3 35
  • 72.29 (n)
  • 75.31 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-89f7.1 36
  • 67 (a)
ManyToMany
FP016199.1 36
  • 59 (a)
ManyToMany
si:ch211-89f7.1 35
  • 69.99 (n)
  • 67.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13893 36
  • 29 (a)
OneToMany
CG13893 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea R03A10.5 36
  • 20 (a)
ManyToMany
H41C03.1 36
  • 23 (a)
ManyToMany
F28H7.8 36
  • 20 (a)
ManyToMany
F20G2.3 36
  • 22 (a)
ManyToMany
F18A11.2 36
  • 19 (a)
ManyToMany
ctg-2 36
  • 24 (a)
ManyToMany
ctg-1 36
  • 27 (a)
ManyToMany
cgr-1 36
  • 22 (a)
ManyToMany
ctg-1 35
  • 44.13 (n)
  • 30.73 (a)
T13H5.2 37
  • 27 (a)
H06O01.3 37
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC14 36
  • 27 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
SEC14 35
  • 44.87 (n)
  • 31.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06479g 35
  • 42.19 (n)
  • 29.46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR020W 35
  • 46.13 (n)
  • 29.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spo20 35
  • 44.76 (n)
  • 34.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02263 35
  • 46.61 (n)
  • 33.77 (a)
Species with no ortholog for SEC14L2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC14L2 Gene

ENSEMBL:
Gene Tree for SEC14L2 (if available)
TreeFam:
Gene Tree for SEC14L2 (if available)

Paralogs for SEC14L2 Gene

Paralogs for SEC14L2 Gene

genes like me logo Genes that share paralogs with SEC14L2: view

Variants for SEC14L2 Gene

Sequence variations from dbSNP and Humsavar for SEC14L2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs715504 -- 30,396,126(+) GTGGG(C/T)ACTCC upstream-variant-2KB
rs737723 -- 30,406,040(+) GAGGA(C/G)GGAAG intron-variant
rs740084 -- 30,396,925(-) GGCGC(C/G)GAAGG upstream-variant-2KB
rs744308 -- 30,397,965(-) AGGGG(G/T)GACAG intron-variant
rs757660 - 30,397,148(+) CCCCA(A/G)GCAGA missense, reference, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SEC14L2 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
nsv914970 CNV Loss 21882294

Variation tolerance for SEC14L2 Gene

Residual Variation Intolerance Score: 41.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.58; 93.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC14L2 Gene

HapMap Linkage Disequilibrium report
SEC14L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L2 Gene

Disorders for SEC14L2 Gene

Relevant External Links for SEC14L2

Genetic Association Database (GAD)
SEC14L2
Human Genome Epidemiology (HuGE) Navigator
SEC14L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC14L2
genes like me logo Genes that share disorders with SEC14L2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC14L2 Gene

Publications for SEC14L2 Gene

  1. Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells. (PMID: 17252538) Ni J. … Yeh S. (Prostate 2007) 23 25 67
  2. A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. (PMID: 10829015) Zimmer S. … Azzi A. (J. Biol. Chem. 2000) 2 23 67
  3. Towards the interaction mechanism of tocopherols and tocotrienols (vitamin E) with selected metabolizing enzymes. (PMID: 19707294) Upadhyay J. … Misra K. (Bioinformation 2009) 23 67
  4. Association of variants in two vitamin e transport genes with circulating vitamin e concentrations and prostate cancer risk. (PMID: 19190344) Wright M.E. … Albanes D. (Cancer Res. 2009) 23 67
  5. Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry. (PMID: 18446792) Weinzierl A.O. … StevanoviA8 S. (Eur. J. Immunol. 2008) 23 67

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