Aliases for SEC14L1 Gene
External Ids for SEC14L1 Gene
Previous HGNC Symbols for SEC14L1 Gene
Previous GeneCards Identifiers for SEC14L1 Gene
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]
GeneCards Summary for SEC14L1 Gene
SEC14L1 (SEC14 Like Lipid Binding 1) is a Protein Coding gene. An important paralog of this gene is SEC14L5.
UniProtKB/Swiss-Prot for SEC14L1 Gene
May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).