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Aliases for SEC14L1 Gene

Aliases for SEC14L1 Gene

  • SEC14-Like 1 (S. Cerevisiae) 2 3
  • SEC14L 3 4 6
  • SEC14 (S. Cerevisiae)-Like 1 2
  • SEC14-Like Protein 1 3
  • PRELID4A 3

External Ids for SEC14L1 Gene

Previous HGNC Symbols for SEC14L1 Gene

  • SEC14L

Previous GeneCards Identifiers for SEC14L1 Gene

  • GC17P074969
  • GC17P078129
  • GC17P075601
  • GC17P075734
  • GC17P072648
  • GC17P075137
  • GC17P070565
  • GC17P075089
  • GC17P075090
  • GC17P075092
  • GC17P075093
  • GC17P075096
  • GC17P075101

Summaries for SEC14L1 Gene

Entrez Gene Summary for SEC14L1 Gene

  • The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]

GeneCards Summary for SEC14L1 Gene

SEC14L1 (SEC14-Like 1 (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with SEC14L1 include brachial plexus neuropathy. An important paralog of this gene is SEC14L6.

Gene Wiki entry for SEC14L1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC14L1 Gene

Genomics for SEC14L1 Gene

Regulatory Elements for SEC14L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEC14L1 Gene

Start:
77,086,716 bp from pter
End:
77,217,101 bp from pter
Size:
130,386 bases
Orientation:
Plus strand

Genomic View for SEC14L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC14L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC14L1 Gene

Proteins for SEC14L1 Gene

  • Protein details for SEC14L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92503-S14L1_HUMAN
    Recommended name:
    SEC14-like protein 1
    Protein Accession:
    Q92503
    Secondary Accessions:
    • A8K4E8
    • B4DDI5
    • D5G3K1
    • Q99780

    Protein attributes for SEC14L1 Gene

    Size:
    715 amino acids
    Molecular mass:
    81250 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEC14L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC14L1 Gene

Proteomics data for SEC14L1 Gene at MOPED

Post-translational modifications for SEC14L1 Gene

  • Ubiquitination at Lys160 and Lys597
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SEC14L1 Gene

Domains for SEC14L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92503

UniProtKB/Swiss-Prot:

S14L1_HUMAN :
  • Q92503
Domain:
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 GOLD domain.
  • Contains 1 PRELI/MSF1 domain.
genes like me logo Genes that share domains with SEC14L1: view

No data available for Gene Families for SEC14L1 Gene

Function for SEC14L1 Gene

Molecular function for SEC14L1 Gene

GENATLAS Biochemistry:
yeast (S cerevisiae) SEC14-like 1,putatively involved in intracellulair transport system,ubiquitously expressed

Phenotypes for SEC14L1 Gene

GenomeRNAi human phenotypes for SEC14L1:
genes like me logo Genes that share phenotypes with SEC14L1: view

Animal Model Products

CRISPR Products

miRNA for SEC14L1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC14L1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC14L1 Gene

Localization for SEC14L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC14L1 Gene COMPARTMENTS Subcellular localization image for SEC14L1 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SEC14L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 8697811
GO:0016020 membrane TAS 8697811
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC14L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEC14L1 Gene

Pathways for SEC14L1 Gene

SuperPathways for SEC14L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEC14L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SEC14L1: view

No data available for Pathways by source for SEC14L1 Gene

Transcripts for SEC14L1 Gene

Unigene Clusters for SEC14L1 Gene

SEC14-like 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEC14L1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC14L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -
SP6:

Relevant External Links for SEC14L1 Gene

GeneLoc Exon Structure for
SEC14L1
ECgene alternative splicing isoforms for
SEC14L1

Expression for SEC14L1 Gene

mRNA expression in normal human tissues for SEC14L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEC14L1 Gene

This gene is overexpressed in Whole Blood (5.3).

Protein differential expression in normal tissues for SEC14L1 Gene

This gene is overexpressed in Bone (40.0) and Adrenal (22.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC14L1 Gene

SOURCE GeneReport for Unigene cluster for SEC14L1 Gene Hs.464184

mRNA Expression by UniProt/SwissProt for SEC14L1 Gene

Q92503-S14L1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with SEC14L1: view

In Situ Assay Products

No data available for Expression partners for SEC14L1 Gene

Orthologs for SEC14L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC14L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEC14L1 35
  • 88.22 (n)
  • 94.97 (a)
SEC14L1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC14L1 35
  • 88.89 (n)
  • 95.8 (a)
SEC14L1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec14l1 35
  • 86.42 (n)
  • 94.7 (a)
Sec14l1 16
Sec14l1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEC14L1 35
  • 99.58 (n)
  • 99.72 (a)
SEC14L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec14l1 35
  • 87.2 (n)
  • 94.71 (a)
oppossum
(Monodelphis domestica)
Mammalia SEC14L1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC14L1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC14L1 35
  • 80.28 (n)
  • 92.06 (a)
SEC14L1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC14L1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec14l5 35
  • 74.39 (n)
  • 86.47 (a)
Str.7219 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6996 35
zebrafish
(Danio rerio)
Actinopterygii sec14l1 35
  • 71.87 (n)
  • 78.5 (a)
zgc55783 35
sec14l1 36
  • 71 (a)
OneToMany
SEC14L1 (2 of 2) 36
  • 88 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9528 37
  • 44 (a)
retm 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T23G5.2 37
  • 46 (a)
T23G5.2 35
  • 54.26 (n)
  • 51.32 (a)
T23G5.2 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
ManyToMany
SEC14 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10399 36
  • 54 (a)
OneToMany
Species with no ortholog for SEC14L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC14L1 Gene

ENSEMBL:
Gene Tree for SEC14L1 (if available)
TreeFam:
Gene Tree for SEC14L1 (if available)

Paralogs for SEC14L1 Gene

Paralogs for SEC14L1 Gene

Pseudogenes.org Pseudogenes for SEC14L1 Gene

genes like me logo Genes that share paralogs with SEC14L1: view

Variants for SEC14L1 Gene

Sequence variations from dbSNP and Humsavar for SEC14L1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12263 -- 77,216,831(+) TATGG(G/T)TTGAG utr-variant-3-prime
rs472359 -- 77,095,842(+) TTACT(G/T)AAATA intron-variant
rs485018 -- 77,118,645(+) CCCCA(A/G)CCAGA intron-variant
rs485450 -- 77,131,856(-) CCTTC(C/T)TTCAG intron-variant
rs485500 -- 77,131,840(-) CCTTC(C/G)TACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC14L1 Gene

Variant ID Type Subtype PubMed ID
esv34174 CNV Loss 18971310
esv2635212 CNV Insertion 19546169
nsv513482 CNV Insertion 21212237
nsv2147 CNV Insertion 18451855
dgv1000e1 CNV Complex 17122850
nsv833551 CNV Gain 17160897
nsv908842 CNV Loss 21882294
nsv908843 CNV Loss 21882294
nsv2148 CNV Insertion 18451855
esv6153 CNV Loss 19470904
esv2716266 CNV Deletion 23290073
esv2675918 CNV Deletion 23128226
esv2050948 CNV Deletion 18987734
esv2716267 CNV Deletion 23290073

Relevant External Links for SEC14L1 Gene

HapMap Linkage Disequilibrium report
SEC14L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC14L1 Gene

Disorders for SEC14L1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SEC14L1 Gene in MalaCards »

(1) Diseases for SEC14L1 Gene including...

(2) University of Copenhagen DISEASES for SEC14L1 Gene

Relevant External Links for SEC14L1

Genetic Association Database (GAD)
SEC14L1
Human Genome Epidemiology (HuGE) Navigator
SEC14L1
genes like me logo Genes that share disorders with SEC14L1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SEC14L1 Gene

Publications for SEC14L1 Gene

  1. Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region. (PMID: 8697811) Chinen K. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 2 3 4 23
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for SEC14L1 Gene

Sources for SEC14L1 Gene

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