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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEC13 Gene

protein-coding GIFtS: 63
GCID: GC03M010337

SEC13 homolog (S. cerevisiae)

(Previous names: SEC13 (S. cerevisiae)-like 1, SEC13-like 1 (S. cerevisiae)...)
(Previous symbols: D3S1231E, SEC13L1)

Explore 6 diseases affiliated with
SEC13 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
SEC13 Homolog (S. Cerevisiae)¹ ²		SEC13-Related Protein² ³
D3S1231E¹ ² ³ ⁵		SEC13 (S. Cerevisiae)-Like 1¹
SEC13L1¹ ² ³ ⁵		SEC13-Like 1 (S. Cerevisiae)¹
SEC13R¹ ² ³ ⁵		Protein SEC13 Homolog²
Npp-20¹		SEC13-Like 1 Isoform²
SEC13-Like Protein 1² ³

External Ids:	HGNC: 10697¹	Entrez Gene: 6396²	Ensembl: ENSG00000157020⁷	OMIM: 600152⁵	UniProtKB: P55735³

ORGUL members:
	NONCODE:n406834 n335700 n406833

Export aliases for SEC13 gene to outside databases

Previous GC identifers: GC03M010318 GC03M010335

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC13:

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the

endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required

for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced

transcript variants have been found. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: SEC13_HUMAN, P55735

Function: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum,

SEC13 is involved in the biogenesis of COPII-coated vesicles

Gene Wiki entry for SEC13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEC13 gene promoter:
E2F-3a E2F-4 E2F-5 RP58 CUTL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEC13 promoter sequence

Search SABiosciences Chromatin IP Primers for SEC13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25-p24 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25-p24

SEC13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC13 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M010337: view genomic region (about GC identifiers)

Start:	10,334,815 bp from pter	End:	10,362,862 bp from pter
Size:	28,048 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

n406834
n406833
n335700

lncRNA
Full Legend

10342614 10352736 10362858 chr3

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEC13_HUMAN, P55735 (See protein sequence)

Recommended Name: Protein SEC13 homolog

Size: 322 amino acids; 35541 Da

Subunit: At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The

Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. At the COPII coat

complex: interacts with SEC31A and SEC31B

Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic

side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex.

Note=In interphase, localizes at both sides of the NPC

Sequence caution: Sequence=AAH02634.2; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for SEC13:

3BG0 (3D)

3BG1 (3D)

Secondary accessions: A8MV37 Q5BJF0 Q9BRM6 Q9BUG7

Alternative splicing: 2 isoforms: P55735-1 P55735-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC13: NX_P55735

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55735

SEC13 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001129704.1 NP_899195.1

ENSEMBL proteins:

ENSP00000380298 ENSP00000336566 ENSP00000312122 ENSP00000380306 ENSP00000373312

ENSP00000401368 ENSP00000400260 ENSP00000398623 ENSP00000404141

Reactome Protein details: P55735
Human Recombinant Protein Products:

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	Novus Biologicals SEC13 Proteins Novus Biologicals SEC13 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SEC13
	Uscn Proteins for SEC13

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000776	colocalizes with kinetochore	IDA	15146057
GO:0005635	nuclear envelope	IDA	15146057
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005829	cytosol	TAS	--
GO:0012507	ER to Golgi transport vesicle membrane	TAS	--

SEC13 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SEC13

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEC13 for domains About GeneDecksing

3 InterPro domains/families:

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry P55735

ProtoNet protein and cluster: P55735

1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: SEC13_HUMAN, P55735

Similarity: Belongs to the WD repeat SEC13 family

Similarity: Contains 6 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SEC13_HUMAN, P55735

Function: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum,

SEC13 is involved in the biogenesis of COPII-coated vesicles

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEC13 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC13
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC13:
		hsa-miR-3910 hsa-miR-4261 hsa-miR-124 hsa-miR-1207-3p hsa-miR-506 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: SEC13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEC13
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC13

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18160040

SEC13 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for SEC13:

Decreased Salmonella enterica	Decreased Salmonella enterica	Increased circadian period len	Nuclear 60S biogenesis defects
Nucleoplasmic pre-40S maturati	Synthetic lethal with Ras

Animal Models:
1 MGI phenotypic allele

for Sec13 (no phenotypes)

SEC13 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

COPII (Coat Protein 2) Mediated Vesicle Transport

	COPII (Coat Protein 2) Mediated Vesicle Transport	1.00			Normal wtCFTR traffic / ER-to-Golgi	0.36
	ER to Golgi Transport	1.00			Delta508-CFTR traffic / ER-to-Golgi in CF	0.36

Clathrin-dependent protein traffic

	Clathrin-dependent protein traffic	1.00			wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)	0.37
	Transport_Clathrin-coated vesicle cycle	0.66

Asparagine N-linked glycosylation

	Asparagine N-linked glycosylation	1.00			Metabolism of proteins	0.15
	Post-translational protein modification	0.44

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SEC13

Clathrin-dependent protein traffic

4 GeneGo (Thomson Reuters) Pathways for SEC13

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Delta508-CFTR traffic / ER-to-Golgi in CF
	Normal wtCFTR traffic / ER-to-Golgi
	Transport Clathrin-coated vesicle cycle

1 BioSystems Pathway for SEC13

SREBP signalling

5/22 Reactome Pathways for SEC13 (see all 22)

	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Membrane Trafficking
	Cell Cycle

2 Kegg Pathways (Kegg details for SEC13):

	RNA transport
	Protein processing in endoplasmic reticulum

SEC13 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEC13

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/171 Interacting proteins for SEC13 (P55735^{1, 2, 3} ENSP00000312122⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 171)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TAB2	Q9NYJ8²^,³	MINT-49202 I2D: score=2
TAF9	Q9Y3D8³, ENSP00000370201⁴	I2D: score=5 STRING: ENSP00000370201
RPN1	P04843³, ENSP00000296255⁴	I2D: score=4 STRING: ENSP00000296255
COPS5	Q92905³, ENSP00000350512⁴	I2D: score=2 STRING: ENSP00000350512
MLST8	Q9BVC4³, ENSP00000371888⁴	I2D: score=2 STRING: ENSP00000371888

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0006886	intracellular protein transport	NAS	7987303

SEC13 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEC13
Search CenterWatch for drugs/clinical trials and news about SEC13

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEC13 gene (4 alternative transcripts):

NM_001136232.1 NM_183352.1 NM_001136026.1 NM_030673.2

Unigene Cluster for SEC13:

SEC13 homolog (S. cerevisiae)

Hs.166924 [show with all ESTs]

Unigene Representative Sequence: NR_024272

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000492602 ENST00000397109(uc003bvm.3) ENST00000337354 ENST00000350697(uc003bvp.3 uc003bvn.3)

ENST00000479868(uc003bvl.3) ENST00000397117 ENST00000383801(uc003bvo.3)

ENST00000477547(uc003bvr.1) ENST00000476597 ENST00000490283 ENST00000482647

ENST00000397105(uc011aul.2) ENST00000431352 ENST00000397102 ENST00000397101

ENST00000397099 ENST00000428626 ENST00000445064

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEC13 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC13
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC13:
		hsa-miR-3910 hsa-miR-4261 hsa-miR-124 hsa-miR-1207-3p hsa-miR-506 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: SEC13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AF052155.1 AK223019.1 AK294662.1 AK301999.1 BC002634.2 BC006167.1 BC091506.1 EF036494.1

L09260.1 NR_024272.1 NR_024273.1

24/28 DOTS entries (see all 28):

DT.100823965 DT.449941 DT.102832646 DT.95159599 DT.95159600 DT.92445337 DT.100823964 DT.100804630

DT.100823960 DT.100823969 DT.100823962 DT.97862198 DT.100701826 DT.100823968 DT.120907303 DT.100823955

DT.100823963 DT.40122936 DT.92032339 DT.92445352 DT.95159607 DT.100702383 DT.120907313 DT.120907319

24/488 AceView cDNA sequences (see all 488):

BG759809 BM920251 BM669432 BM449663 AU142469 BM821708 BP336840 CA397118

AI923709 BX460874 AU122171 CB163160 CR606959 BP382364 CB161683 BQ954044

BM352654 F31621 BU845967 NM_030673 CA432105 W72857 BM800472 BQ671421

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for SEC13 (see all 18) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	^	12	^
SP1:									-		-		-		-		-		-		-		-								-		-		-		-												-
SP2:													-		-		-		-		-		-								-		-		-		-												-
SP3:																															-		-		-		-												-
SP4:									-		-		-		-		-		-												-		-		-		-												-
SP5:																															-		-		-		-												-

ExUns:	13a	·	13b	^	14a	·	14b	^	15	^	16
SP1:							-
SP2:							-
SP3:							-
SP4:
SP5:

ECgene alternative splicing isoforms for SEC13

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEC13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACGAGGAA

About this image

SEC13 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Rostral Endochondral Facial Bones

Bone

Rostral Skull Membranous Bones

Bone

Cartilage

Caudal Synchondroses

Cartilage

Chondrocranium

Cartilage

Rostral Chondrocranium

Cartilage

Rostral Synchondroses

Cartilage

Synchondroses

Cartilage

Head Mesenchyme

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEC13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEC13

SOURCE GeneReport for Unigene cluster: Hs.166924

SABiosciences Custom PCR Arrays for SEC13

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC13 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC13

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC13 gene from 10/40 species (see all 40) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sec13^{1 , 5}	SEC13 homolog (S. cerevisiae)^{1, 5}	89.44(n)¹ 96.89(a)¹		6 (52.84 cM)⁵ 110379¹ NM_024206.4¹ NP_077168.2¹ 113728067⁵
chicken (Gallus gallus)	Aves	SEC13¹	SEC13 homolog (S. cerevisiae)	80.94(n) 94.06(a)		416119 XM_414450.3 XP_414450.3
lizard (Anolis carolinensis)	Reptilia	SEC13⁶	--	92(a)	1 ↔ 1	GL343273.1(845097-854389)
African clawed frog (Xenopus laevis)	Amphibia	BC043755.1²	--	79.34(n)		BC043755.1
zebrafish (Danio rerio)	Actinopterygii	wufa08f09²	Danio rerio cDNA clone MGC63980 IMAGE6792353, complete cds less	81.44(n)		BC054585.1
fruit fly (Drosophila melanogaster)	Insecta	sec13¹	CG6773-PA	61.52(n) 59.73(a)		44437 NM_143720.3 NP_651977.1
worm (Caenorhabditis elegans)	Secernentea	npp-20¹	Protein NPP-20	49.61(n) 43.89(a)		176957 NM_067685.2 NP_500086.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SEC13(YLR208W)⁴ SEC13¹	Component of the Nup84 nuclear pore sub-complex, the Sec13p-Sec31p complex of the COPII vesicle coat, and the SEA (Seh1-associated) complex; required for vesicle formation in ER to Golgi transport and nuclear pore complex organization; the Nup84 subcomplex has a role in transcription elongation less⁴ Sec13p¹	54.98(n)¹ 52.58(a)¹		12(559551-560444)⁴ 850905^{1, 4} NP_013309.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G30050¹	protein transport protein SEC13	58.42(n) 56.36(a)		817556 NM_128560.2 NP_180566.1
rice (Oryza sativa)	Liliopsida	Os.8830²	Oryza sativa mRNA for Sec13p, complete cds	72.27(n)		AK112028.1

ENSEMBL Gene Tree for SEC13 (if available)
TreeFam Gene Tree for SEC13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SEC13 gene

3 SIMAP similar genes for SEC13 using alignment to 7 protein entries: SEC13_HUMAN (see all proteins):

SEH1L PF20 RBBP4

SEC13 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SEC13
PGOHUM00000237987 PGOHUM00000236259

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116935409^1,2	F,	--	10342127(+)	`GGTGAT/CACCTG`	4	--	ds500¹		1		EA	120
rs190208880^1,2		--	10342164(+)	`ATGGGC/GCCCTC`	4	--	ds500¹		0	--	--	--	--
rs183413961^1,2		--	10342170(+)	`CCCTCC/TTTTTC`	4	--	ds500¹		0	--	--	--	--
rs145701984^1,2		--	10342181(+)	`CTGACA/GGGGTC`	4	--	ds500¹		0	--	--	--	--
rs147324045^1,2		--	10342255(+)	`TACCAC/TGTTGC`	4	--	ds500¹		0	--	--	--	--
rs149162^1,2	C,F,A,H,	--	10342262(+)	`TTGCAT/CCTGCG`	4	--	ds500¹ ese³		26		NS EA NA WA CSA	2351
rs148783581^1,2		--	10342388(+)	`GCAGAC/TCCAGG`	4	--	ds500¹		0	--	--	--	--
rs139572180^1,2	C,	--	10342417(+)	`AAGGC-/TGAG TGAGT`	4	--	ds500¹		0	--	--	--	--
rs188811483^1,2		--	10342559(+)	`TGGACC/TGACAA`	4	--	ds500¹		0	--	--	--	--
rs2287545^1,2	C,F,	--	10342571(+)	`AGTCAA/CACTGA`	4	--	ds500¹ ese³		2		EA	1614

HapMap Linkage Disequilibrium report for SEC13 (10334815 - 10362862 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEC13: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC13

DNA2.0 Custom Variant and Variant Library Synthesis for SEC13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SEC13 for disorders           About GeneDecksing

OMIM gene information: 600152    OMIM disorders: --

6 diseases for SEC13:    About MalaCards

atrioventricular septal defect congenital dyserythropoietic anemia dyserythropoietic anemia stomatitis

anemia malaria

Human Genome Epidemiology (HuGE) Navigator: SEC13 (1 document)

Export disorders for SEC13 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SEC13 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with SEC13)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6. (PubMed id 7987303)^{1, 2, 3, 9} Swaroop A.... Smith D.I. (1994)
Architecture of a coat for the nuclear pore membrane. (PubMed id 18160040)^{1, 2} Hsia K.C....Hoelz A. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex. (PubMed id 14517296)^{1, 2} Enninga J....Fontoura B.M. (2003)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{1, 2} Yu W.... Gibbs R.A. (1997)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Epithelial organization and cyst lumen expansion requi re efficient Sec13-Sec31-driven secretion. (PubMed id 22331354)¹ Townley A.K....Stephens D.J. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6396	HGNC: 10697	AceView: SEC13L1	Ensembl:ENSG00000157020	euGenes: HUgn6396
ECgene: SEC13	Kegg: 6396	H-InvDB: SEC13

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEC13	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEC13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEC13 gene:
Search GeneIP for patents involving SEC13

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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SEC13 homolog (S. cerevisiae)

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