Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEC13 Gene

protein-coding   GIFtS: 64
GCID: GC03M010350

SEC13 Homolog (S. Cerevisiae)

(Previous names: SEC13 (S. cerevisiae)-like 1, SEC13-like 1 (S. cerevisiae))
(Previous symbols: D3S1231E, SEC13L1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SEC13 Homolog (S. Cerevisiae)1 2     SEC13 (S. Cerevisiae)-Like 11
D3S1231E1 2 3 5     SEC13-Like 1 (S. Cerevisiae)1
SEC13L11 2 3 5     npp-202
SEC13R2 3 5     Protein SEC13 Homolog2
SEC13-Like Protein 12 3     SEC13-Like 1 Isoform2
SEC13-Related Protein2 3     

External Ids:    HGNC: 106971   Entrez Gene: 63962   Ensembl: ENSG000001570207   OMIM: 6001525   UniProtKB: P557353   

Export aliases for SEC13 gene to outside databases

Previous GC identifers: GC03M010318 GC03M010335 GC03M010337


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEC13 Gene:
The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the
endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is
required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple
alternatively spliced transcript variants have been found. (provided by RefSeq, Oct 2008)

GeneCards Summary for SEC13 Gene:
SEC13 (SEC13 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SEC13 include atrioventricular septal defect, and congenital dyserythropoietic anemia.

UniProtKB/Swiss-Prot: SEC13_HUMAN, P55735
Function: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic
reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. As a component of the GATOR2 complex,
inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway

Gene Wiki entry for SEC13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC13 gene promoter:
         E2F-3a   E2F-4   E2F-5   RP58   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC13 promoter sequence
   Search Chromatin IP Primers for SEC13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25-p24   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25-p24

SEC13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC13 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M010350:  view genomic region     (about GC identifiers)

Start:
10,334,815 bp from pter      End:
10,362,862 bp from pter
Size:
28,048 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SEC13

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SEC13_HUMAN, P55735 (See protein sequence)
Recommended Name: Protein SEC13 homolog  
Size: 322 amino acids; 35541 Da
Subunit: At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC).
The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. At the
COPII coat complex: interacts with SEC31A and SEC31B. Within the GATOR complex, component of the GATOR2
subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC
and RRAGB/RRAGC heterodimers
Sequence caution: Sequence=AAH02634.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for SEC13:
3BG0 (3D)        3BG1 (3D)    
Secondary accessions: A8MV37 Q5BJF0 Q9BRM6 Q9BUG7
Alternative splicing: 2 isoforms:  P55735-1   P55735-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEC13: NX_P55735

Explore proteomics data for SEC13 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38
  • Modification sites at PhosphoSitePlus

  • See SEC13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001129498.1  NP_001129704.1  NP_001265875.1  NP_109598.2  NP_899195.1  

    ENSEMBL proteins: 
     ENSP00000380298   ENSP00000336566   ENSP00000312122   ENSP00000380306   ENSP00000373312  
     ENSP00000401368   ENSP00000400260   ENSP00000398623   ENSP00000404141  
    Reactome Protein details: P55735

    SEC13 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SEC13
    OriGene Protein Over-expression Lysate for SEC13
    OriGene MassSpec for SEC13
    OriGene Custom Protein Services for SEC13
    GenScript Custom Purified and Recombinant Proteins Services for SEC13
    Novus Biologicals SEC13 Proteins
    Novus Biologicals SEC13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SEC13
    Cloud-Clone Corp. Proteins for SEC13

    SEC13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SEC13
    OriGene Custom Antibody Services for SEC13
    Novus Biologicals SEC13 Antibodies
    Abcam antibodies for SEC13
    Cloud-Clone Corp. Antibodies for SEC13
    ThermoFisher Antibodies for SEC13
    LSBio Antibodies in human, mouse, rat for SEC13

    SEC13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEC13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEC13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEC13
    Cloud-Clone Corp. CLIAs for SEC13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry P55735

    ProtoNet protein and cluster: P55735

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: SEC13_HUMAN, P55735
    Similarity: Belongs to the WD repeat SEC13 family
    Similarity: Contains 6 WD repeats


    SEC13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEC13_HUMAN, P55735
    Function: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic
    reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. As a component of the GATOR2 complex,
    inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15146057
         
    SEC13 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for SEC13:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Increased circadian period len  Nuclear 60S biogenesis defects 
     Nucleoplasmic pre-40S maturati  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Sec13 (no phenotypes)

    SEC13 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC13

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC13:
    hsa-mir-99a-5p (MIRT048659), hsa-mir-505-3p (MIRT041012), hsa-mir-652-3p (MIRT039516)

    Block miRNA regulation of human, mouse, rat SEC13 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SEC13:
    hsa-miR-3910 hsa-miR-4261 hsa-miR-124 hsa-miR-1207-3p hsa-miR-506 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidSEC13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEC13
    Predesigned siRNA for gene silencing in human, mouse, rat SEC13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC13

    Clone
    Products:
         
    OriGene clones in human, mouse for SEC13 (see all 12)
    OriGene ORF clones in mouse, rat for SEC13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEC13 (NM_183352)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEC13
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEC13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SEC13_HUMAN, P55735: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic
    side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore
    complex. Note=In interphase, localizes at both sides of the NPC
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol4
    cytoskeleton2
    golgi apparatus2
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0000776colocalizes with kinetochore IDA15146057
    GO:0005635nuclear envelope IDA15146057
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005829cytosol TAS--

    SEC13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SEC13 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1ER to Golgi Transport
    ER to Golgi Transport0.36
    Antigen Presentation- Folding, assembly and peptide loading of class I MHC0.32
    Delta508 CFTR traffic ER to Golgi in CF0.36
    COPII (Coat Protein 2) Mediated Vesicle Transport0.00
    Normal wtCFTR traffic ER to Golgi 0.36
    2Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Transport to the Golgi and subsequent modification0.40
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 GeneGo (Thomson Reuters) Pathways for SEC13
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SEC13
        SREBP signalling

    Selected Reactome Pathways for SEC13 (see all 6)
        Resolution of Sister Chromatid Cohesion
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Mitotic Prometaphase
    Separation of Sister Chromatids
    COPII (Coat Protein 2) Mediated Vesicle Transport


    2 Kegg Pathways  (Kegg details for SEC13):
        RNA transport
    Protein processing in endoplasmic reticulum


    SEC13 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC13
    Interactions:

        Search GeneGlobe Interaction Network for SEC13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC13 (P557351, 2, 3 ENSP000003121224) via UniProtKB, MINT, STRING, and/or I2D (see all 214)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB2Q9NYJ82, 3MINT-49202 I2D: score=2 
    RPN1P048433, ENSP000002962554I2D: score=4 STRING: ENSP00000296255
    SEC16BQ96JE73, ENSP000003083394I2D: score=3 STRING: ENSP00000308339
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    MLST8Q9BVC43, ENSP000003718884I2D: score=2 STRING: ENSP00000371888
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006886intracellular protein transport NAS7987303
    GO:0006888ER to Golgi vesicle-mediated transport TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    SEC13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC13



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEC13 gene (5 alternative transcripts): 
    NM_001136026.2  NM_001136232.2  NM_001278946.1  NM_030673.3  NM_183352.2  

    Unigene Cluster for SEC13:

    SEC13 homolog (S. cerevisiae)
    Hs.166924  [show with all ESTs]
    Unigene Representative Sequence: NR_024272
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000492602 ENST00000397109(uc003bvm.3) ENST00000337354 ENST00000350697(uc003bvp.3 uc003bvn.3)
    ENST00000479868(uc003bvl.3) ENST00000397117 ENST00000383801(uc003bvo.3)
    ENST00000477547(uc003bvr.1) ENST00000476597 ENST00000490283 ENST00000482647
    ENST00000397105(uc011aul.2) ENST00000431352 ENST00000397102 ENST00000397101
    ENST00000397099 ENST00000428626 ENST00000445064
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEC13 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SEC13:
    hsa-miR-3910 hsa-miR-4261 hsa-miR-124 hsa-miR-1207-3p hsa-miR-506 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidSEC13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEC13
    Predesigned siRNA for gene silencing in human, mouse, rat SEC13
    Clone
    Products:
         
    OriGene clones in human, mouse for SEC13 (see all 12)
    OriGene ORF clones in mouse, rat for SEC13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEC13 (NM_183352)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC13
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEC13
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC13
      QuantiTect SYBR Green Assays in human, mouse, rat SEC13
      QuantiFast Probe-based Assays in human, mouse, rat SEC13

    Additional mRNA sequence: 

    AF052155.1 AK223019.1 AK294662.1 AK301999.1 BC002634.2 BC006167.1 BC091506.1 EF036494.1 
    L09260.1 NR_024272.1 NR_024273.1 

    Selected DOTS entries (see all 28):

    DT.100823965  DT.449941  DT.102832646  DT.95159599  DT.95159600  DT.100823964  DT.92445337  DT.100804630 
    DT.100823960  DT.100823969  DT.97862198  DT.100701826  DT.100823962  DT.100823968  DT.120907303  DT.100823955 
    DT.100823963  DT.40122936  DT.92032339  DT.92445352  DT.100702383  DT.120907313  DT.120907319  DT.120907328 

    Selected AceView cDNA sequences (see all 488):

    BU845967 AI923709 CR620379 CR606959 AW952593 AU122171 CB163160 W72857 
    W76281 BM800472 CB161683 BM669432 BQ671421 AI206685 CA432105 F31621 
    BM920251 NM_030673 BM982378 BM704734 BQ954044 CA397118 BM352654 AW439640 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEC13 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^
    SP1:                          -     -     -     -     -     -     -     -                       -     -     -     -                                   -         
    SP2:                                      -     -     -     -     -     -                       -     -     -     -                                   -         
    SP3:                                                                                            -     -     -     -                                   -         
    SP4:                          -     -     -     -     -     -                                   -     -     -     -                                   -         
    SP5:                                                                                            -     -     -     -                                   -         

    ExUns: 13a · 13b ^ 14a · 14b ^ 15 ^ 16
    SP1:                    -               
    SP2:                    -               
    SP3:                    -               
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SEC13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEC13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACGAGGAA
    SEC13 Expression
    About this image

    SEC13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.166924
        Custom PCR Arrays for SEC13
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEC13
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC13
    QuantiTect SYBR Green Assays in human, mouse, rat SEC13
    QuantiFast Probe-based Assays in human, mouse, rat SEC13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC13 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec131 , 5 SEC13 homolog (S. cerevisiae)1, 5 89.44(n)1
    96.89(a)1
      6 (52.84 cM)5
    1103791  NM_024206.41  NP_077168.21 
     1137280675 
    chicken
    (Gallus gallus)
    Aves SEC131 SEC13 homolog (S. cerevisiae) 80.94(n)
    94.06(a)
      416119  NM_001277841.1  NP_001264770.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC136
    SEC13 homolog (S. cerevisiae)
    82(a)
    1 ↔ 1
    GL343273.1(842316-855490)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043755.12   -- 79.34(n)    BC043755.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa08f092 Danio rerio cDNA clone MGC63980 IMAGE6792353, complete more 81.44(n)    BC054585.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec131 sec13 61.63(n)
    59.73(a)
      44437  NM_143720.4  NP_651977.1 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-201 npp-20 50.06(n)
    43.89(a)
      176957  NM_067685.3  NP_500086.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC13(YLR208W)4
    SEC131
    Component of the Nup84 nuclear pore sub-complex, the more4
    SEC131
    55.22(n)1
    53.06(a)1
      12(559551-560444)4
    8509051, 4  NP_013309.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G300501 AT2G30050 58.42(n)
    56.36(a)
      817556  NM_128560.2  NP_180566.1 
    rice
    (Oryza sativa)
    Liliopsida Os.88302 Oryza sativa mRNA for Sec13p, complete cds 72.27(n)    AK112028.1 


    ENSEMBL Gene Tree for SEC13 (if available)
    TreeFam Gene Tree for SEC13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEC13 gene
    3 SIMAP similar genes for SEC13 using alignment to 7 protein entries:     SEC13_HUMAN (see all proteins):
    SEH1L    PF20    RBBP4

    SEC13 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SEC13
    PGOHUM00000237987 PGOHUM00000236259


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEC13 (see all 588)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000660641,2
    C--10300200(+) GCTGT-/AGGGTAT 2 -- us2k10--------
    rs1169354091,2
    F--10342127(+) GGTGAT/CACCTG 4 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1902088801,2
    --10342164(+) ATGGGC/GCCCTC 4 -- ds50010--------
    rs1834139611,2
    --10342170(+) CCCTCC/TTTTTC 4 -- ds50010--------
    rs1457019841,2
    C--10342181(+) CTGACA/GGGGTC 4 -- ds50010--------
    rs1473240451,2
    C--10342255(+) TACCAC/TGTTGC 4 -- ds50010--------
    rs1491621,2
    C,F,A,H--10342262(+) TTGCAT/CCTGCG 4 -- ds5001 ese326Minor allele frequency- C:0.17NS EA NA WA CSA 2351
    rs1487835811,2
    --10342388(+) GCAGAC/TCCAGG 4 -- ds50010--------
    rs1395721801,2
    C--10342417(+) AAGGC-/TGAG  
            
    TGAGT
    4 -- ds50010--------
    rs1888114831,2
    --10342559(+) TGGACC/TGACAA 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for SEC13 (10334815 - 10362862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SEC13:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv809e201CNV Deletion23290073
    nsv436362CNV Deletion17901297
    esv2556727CNV Deletion19546169
    nsv508903CNV Insertion20534489
    nsv436869CNV Insertion17901297
    esv4117CNV Complex18987735

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC13
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600152    OMIM disorders: --

    3 diseases for SEC13:    About MalaCards
    atrioventricular septal defect    congenital dyserythropoietic anemia    malaria


    SEC13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEC13
    Human Genome Epidemiology (HuGE) Navigator: SEC13 (1 document)

    Export disorders for SEC13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEC13 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with SEC13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6. (PubMed id 7987303)1, 2, 3, 9 Swaroop A.... Smith D.I. (Hum. Mol. Genet. 1994)
    2. Architecture of a coat for the nuclear pore membrane. (PubMed id 18160040)1, 2 Hsia K.C.... Hoelz A. (Cell 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex. (PubMed id 14517296)1, 2 Enninga J.... Fontoura B.M. (Mol. Cell. Biol. 2003)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    6. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (Genome Res. 1997)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. (PubMed id 23723238)2 Bar-Peled L....Sabatini D.M. (Science 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6396 HGNC: 10697 AceView: SEC13L1 Ensembl:ENSG00000157020 euGenes: HUgn6396
    ECgene: SEC13 Kegg: 6396 H-InvDB: SEC13

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEC13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEC13 gene:
    Search GeneIP for patents involving SEC13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SEC13   OriGene RNAi products in human, mouse, rat for SEC13  
     OriGene qPCR primer pairs and template standards for SEC13   OriGene Protein Over-expression Lysate for SEC13  
     OriGene MassSpec something-or-other for SEC13   OriGene clones in human, mouse for SEC13  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEC13   OriGene Purified Protein for SEC13  
     OriGene ORF clones in mouse, rat for SEC13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEC13   OriGene Custom Protein Services for SEC13  

     
     
     Block miRNA regulation of human, mouse, rat SEC13 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEC13
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC13 Predesigned siRNA for gene silencing in human, mouse, rat SEC13
     QuantiFast Probe-based Assays in human, mouse, rat SEC13 QuantiTect SYBR Green Assays in human, mouse, rat SEC13
     Custom PCR Arrays for SEC13 Search Chromatin IP Primers for SEC13
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC13  Search GeneGlobe Interaction Network for SEC13
     Regulatory tfbs in SEC13 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEC13 GenScript cDNA clones with any tag delivered in your preferred vector for SEC13
     GenScript Custom Assay Services for SEC13 GenScript Custom overexpressing Cell Line Services for SEC13
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEC13
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEC13 antibodies
     SEC13 proteins
     SEC13 lysates
     Antibodies for SEC13
     See all of Abcam's Antibodies, Kits and Proteins for SEC13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SEC13
     Proteins for SEC13
     Antibodies for SEC13
     ELISAs for SEC13
     CLIAs for SEC13



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEC13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC13
     SwitchGear 3'UTR luciferase reporter plasmids for SEC13
     SwitchGear Promoter luciferase reporter plasmids for SEC13
     ThermoFisher Antibodies for SEC13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC13
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC13
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC13
     LSBio Antibodies in human, mouse, rat for SEC13
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEC13 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4