Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC11C Gene

protein-coding   GIFtS: 50
GCID: GC18P056807

SEC11 homolog C (S. cerevisiae)

(Previous name: SEC11-like 3 (S. cerevisiae) )
(Previous symbol: SEC11L3)
 Explore 1 disease affiliated with
SEC11C via our new
 Human Malady Compendium 
Biological research products
for SEC11C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SEC11 Homolog C (S. Cerevisiae)1 2     SPase 21 KDa Subunit2 3
SEC11L31 2 3     SEC11-Like 3 (S. Cerevisiae)1
SPC211 2 3     SEC11-Like 32
SPCS4C1 2 3     Signal Peptidase Complex Catalytic Subunit SEC11C2
Microsomal Signal Peptidase 21 KDa Subunit2 3     EC 3.4.21.893
SEC11-Like Protein 32 3     SEC11 Homolog C3

External Ids:    HGNC: 234001   Entrez Gene: 907012   Ensembl: ENSG000001665627   UniProtKB: Q9BY503   

Export aliases for SEC11C gene to outside databases

Previous GC identifers: GC18P054960 GC18P053515


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SC11C_HUMAN, Q9BY50
Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as
they are translocated into the lumen of the endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC11C gene promoter:
         HSF1 (long)   Pax-2   Pax-2a   Egr-4   POU2F1   HSF2   POU2F1a   SEF-1 (1)   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC11C promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC11C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC11C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.32   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21.32

SEC11C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC11C gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P056807:  view genomic region     (about GC identifiers)

Start:
56,806,709 bp from pter      End:
56,826,068 bp from pter
Size:
19,360 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SC11C_HUMAN, Q9BY50 (See protein sequence)
Recommended Name: Signal peptidase complex catalytic subunit SEC11C  
Size: 192 amino acids; 21542 Da
Subunit: Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1,
SPCS2 and SPCS3 (By similarity)
Subcellular location: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum
membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: B2RAA3

Explore the universe of human proteins at neXtProt for SEC11C: NX_Q9BY50

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BY50

  • SEC11C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_150596.1  
    ENSEMBL proteins: 
     ENSP00000468633   ENSP00000299714   ENSP00000465281  
    Reactome Protein details: Q9BY50
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SEC11C
    OriGene Protein Over-expression Lysate: SEC11C
    OriGene Custom Protein Services for SEC11C 
    GenScript Custom Purified and Recombinant Proteins Services for SEC11C
    Novus Biologicals SEC11C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEC11C

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--


    SEC11C for ontologies           About GeneDecksing



    SEC11C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEC11C 
    GenScript Custom Superior Antibodies Services for SEC11C
    Novus Biologicals SEC11C Antibodies
    Search for Antibodies for SEC11C at Abcam  
    Uscn Antibodies for SEC11C
    ThermoFisher Antibodies for SEC11C

    Assay Products for SEC11C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEC11C
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SEC11C


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SEC11C for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR019759 Peptidase_S24_S26
     IPR001733 Peptidase_S26B
     IPR015927 Peptidase_S24_S26A/B/C
     IPR011056 Peptidase_S24_S26A/B/C_b-rbn
     IPR019758 Pept_S26A_signal_pept_1_CS

    Graphical View of Domain Structure for InterPro Entry Q9BY50

    ProtoNet protein and cluster: Q9BY50

    2 Blocks protein families:
    IPB000223 Bacterial leader peptidase 1 (S26) family signature
    IPB001733 Eukaryotic signal peptidase (S27) family signature


    UniProtKB/Swiss-Prot: SC11C_HUMAN, Q9BY50
    Similarity: Belongs to the peptidase S26B family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SC11C_HUMAN, Q9BY50
    Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as
    they are translocated into the lumen of the endoplasmic reticulum (By similarity)
    Catalytic activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic
    proteins

    Enzyme Number (IUBMB): EC 3.4.21.891

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC11C:
    hsa-mir-30a (MIRT005192)

    OriGene 3'-UTR Clone: SEC11C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC11C
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SEC11C:
    hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidSEC11C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC11C (see all 7)
    OriGene shRNA RFP: SEC11C
    OriGene siRNA: SEC11C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC11C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC11C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC11C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC11C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEC11C (NM_033280)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC11C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC11C 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEC11C
    Search LifeMap BioReagents cell lines for SEC11C

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC11C

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008236serine-type peptidase activity IEA--


    SEC11C for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)1.00
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.78
    Incretin Synthesis, Secretion, and Inactivation0.89
    Synthesis, Secretion, and Deacylation of Ghrelin0.46
    2Synthesis of PB1-F2
    SRP-dependent cotranslational protein targeting to membrane0.77
    Translation0.57
    3Protein export
    Protein export1.00
    4Generic Transcription Pathway
    Gene Expression0.46
    5Insulin Processing
    Peptide hormone metabolism0.39

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/9        Reactome Pathways for SEC11C (see all 9)
        Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Incretin Synthesis, Secretion, and Inactivation
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Synthesis, Secretion, and Deacylation of Ghrelin


    1         Kegg Pathway  (Kegg details for SEC11C):
        Protein export


    SEC11C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC11C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/120 Interacting proteins for SEC11C (Q9BY503 ENSP000002997144) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    RER1O152583, ENSP000003020884I2D: score=1 STRING: ENSP00000302088
    UBA52P629873, ENSP000003881074I2D: score=1 STRING: ENSP00000388107
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    COPB1P536183, ENSP000002499234I2D: score=1 STRING: ENSP00000249923
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006412translation TAS--
    GO:0006465signal peptide processing IEA--
    GO:0006508proteolysis IEA--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--


    SEC11C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC11C
    Search CenterWatch for drugs/clinical trials and news about SEC11C / SC11C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC11C gene: 
    NM_033280.2  

    Unigene Cluster for SEC11C:

    SEC11 homolog C (S. cerevisiae)
    Hs.45107  [show with all ESTs]
    Unigene Representative Sequence: AK295346
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587834 ENST00000509791(uc010xej.1) ENST00000299714(uc010dpo.1 uc002lht.3)
    ENST00000585864 ENST00000593132 ENST00000592774 ENST00000588875 ENST00000591406


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SEC11C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEC11C
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SEC11C:
    hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidSEC11C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC11C (see all 7)
    OriGene shRNA RFP: SEC11C
    OriGene siRNA: SEC11C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC11C
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC11C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC11C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEC11C (NM_033280)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC11C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC11C 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC11C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC11C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC11C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC11C

    Additional cDNA sequence: 

    AF212233.1 AK295346.1 AK307127.1 AK314107.1 BC009703.1 

    7 DOTS entries:

    DT.114271  DT.92424588  DT.100722149  DT.121102693  DT.454030  DT.121102711  DT.110084 

    24/190 AceView cDNA sequences (see all 190):

    BF055352 AA417644 BQ417397 AI815497 BE620995 BM468471 BF513795 AA299888 
    AA644345 CD678962 CD239949 BM311420 AI816219 BX280064 AA419548 CD634956 
    BQ417149 BU167523 BU784611 AI698157 BM760252 N45014 BM971968 AI740538 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEC11C (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                    -     -     -     -                 -           -                     
    SP2:                    -     -     -     -                 -           -     -               
    SP3:                    -     -     -     -                 -                                 
    SP4:                    -     -     -     -                                                   
    SP5:                    -     -                                                               


    ECgene alternative splicing isoforms for SEC11C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC11C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAAGATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SEC11C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC11C

    SOURCE GeneReport for Unigene cluster: Hs.45107
        SABiosciences Custom PCR Arrays for SEC11C
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC11C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEC11C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC11C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC11C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC11C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC11C gene from 7/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SEC11C1 SEC11 homolog C (S. cerevisiae) 85.27(n)
    92.82(a)
      426850  XM_424458.3  XP_424458.3 
    lizard
    (Anolis carolinensis)
    Reptilia SEC11C6
    --
    89(a)
    1 ↔ 1
    GL343335.1(1112073-1125532)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX852927.12   -- 80.37(n)    BX852927.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta twr1 twisted bristles roughened eye 67.43(n)
    76(a)
      40815  NM_141419.4  NP_649676.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y54E10BR.51 Protein Y54E10BR.5 63.43(n)
    72(a)
      171876  NM_058691.3  NP_491092.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G157101 signal peptidase, endoplasmic reticulum-type 61.74(n)
    59.17(a)
      820814  NM_112441.3  NP_566523.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109902 Oryza sativa (japonica cultivar-group) cDNA clone0 more 77.78(n)    AK106215.1 


    ENSEMBL Gene Tree for SEC11C (if available)
    TreeFam Gene Tree for SEC11C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC11C gene
    SEC11A2  
    5 SIMAP similar genes for SEC11C using alignment to 2 protein entries:     SC11C_HUMAN (see all proteins):
    SEC11L3    SEC11L1    SPC18    SEC11B    SEC11A

    SEC11C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/413 NCBI SNPs in SEC11C are shown (see all 413    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs602090091,2
    F,--56805131(+) CCCAAT/CGTCTT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1512752801,2
    --56805184(+) TGGAGA/GCTGGG 1 -- us2k10--------
    rs1405232021,2
    --56805185(+) GGAGGA/CTGGGC 1 -- us2k10--------
    rs1854092991,2
    --56805194(+) GCCAAA/TGGTTC 1 -- us2k10--------
    rs1459339241,2
    --56805323(+) CCTTCC/TAGTTC 1 -- us2k10--------
    rs1902709211,2
    --56805390(+) ATTTAC/TTCTTT 1 -- us2k10--------
    rs778405941,2
    F,--56805426(+) CAAAAT/CGTATC 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1828818731,2
    --56805476(+) AATTAC/TTAGTG 1 -- us2k10--------
    rs1388631241,2
    --56805551(+) TACATA/CTGATA 1 -- us2k10--------
    rs583820111,2
    C,F,--56805684(+) CAGTGG/AGACTT 1 -- us2k19Minor allele frequency- A:0.31WA NA CSA EA 369

    HapMap Linkage Disequilibrium report for SEC11C (56806709 - 56826068 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SEC11C: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC11C
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC11C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEC11C for disorders           About GeneDecksing

    1 disease for SEC11C:    About MalaCards
    malaria


    Export disorders for SEC11C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC11C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SEC11C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    9. The role of assembly in insulin's biosynthesis. (PubMed id 9631292)1 Dodson G. and Steiner D. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90701 HGNC: 23400 AceView: LOC90701 Ensembl:ENSG00000166562 euGenes: HUgn90701
    ECgene: SEC11C Kegg: 90701 H-InvDB: SEC11C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC11C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC11C gene:
    Search GeneIP for patents involving SEC11C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SEC11C  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEC11C   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEC11C  
     OriGene Protein Over-expression Lysate for SEC11C   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SEC11C   OriGene 3'-UTR Clone for SEC11C  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEC11C   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEC11C  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SEC11C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEC11C   OriGene Custom Protein Services for SEC11C  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEC11C
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEC11C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC11C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEC11C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEC11C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEC11C
     GenScript Custom Purified and Recombinant Proteins Services for SEC11C GenScript cDNA clones with any tag delivered in your preferred vector for SEC11C
     GenScript Custom Assay Services for SEC11C GenScript Custom Superior Antibodies Services for SEC11C
     GenScript Custom overexpressing Cell Line Services for SEC11C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SEC11C promoter
     Search Chromatin IP Primers for SEC11C
     RT2 qPCR Primer Assay in human, mouse, rat SEC11C
     Search GNC Networks for SEC11C
     SABiosciences Custom PCR Arrays for SEC11C
     Search Tocris compounds for SEC11C
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SEC11C antibodies
     SEC11C lysates
     Search for Antibodies for SEC11C at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SEC11C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SEC11C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SEC11C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC11C
     SwitchGear 3'UTR luciferase reporter plasmids for SEC11C
     SwitchGear Promoter luciferase reporter plasmids for SEC11C
     ThermoFisher Antibodies for SEC11C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC11C
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEC11C gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4