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Aliases for SEC11C Gene

Aliases for SEC11C Gene

  • SEC11 Homolog C, Signal Peptidase Complex Subunit 2 3 5
  • Microsomal Signal Peptidase 21 KDa Subunit 3 4
  • Signal Peptidase Complex 21 2 3
  • SEC11-Like Protein 3 3 4
  • SPase 21 KDa Subunit 3 4
  • SEC11L3 3 4
  • SPCS4C 3 4
  • SPC21 3 4
  • Signal Peptidase Complex Catalytic Subunit SEC11C 3
  • SEC11 Homolog C (S. Cerevisiae) 2
  • SEC11-Like 3 (S. Cerevisiae) 2
  • SEC11 Homolog C 4
  • SEC11-Like 3 3
  • EC 3.4.21.89 4

External Ids for SEC11C Gene

Previous HGNC Symbols for SEC11C Gene

  • SEC11L3

Previous GeneCards Identifiers for SEC11C Gene

  • GC18P054960
  • GC18P056807
  • GC18P053515

Summaries for SEC11C Gene

GeneCards Summary for SEC11C Gene

SEC11C (SEC11 Homolog C, Signal Peptidase Complex Subunit) is a Protein Coding gene. Among its related pathways are Incretin synthesis, secretion, and inactivation and Gene Expression. GO annotations related to this gene include peptidase activity and serine-type peptidase activity. An important paralog of this gene is SEC11A.

UniProtKB/Swiss-Prot for SEC11C Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC11C Gene

Genomics for SEC11C Gene

Regulatory Elements for SEC11C Gene

Enhancers for SEC11C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G059138 1.1 ENCODE 11.8 +1.8 1816 4.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 SEC11C ZNF532 GRP LOC100286992
GH18G059123 0.6 ENCODE 10.3 -15.6 -15631 1.1 JUND ZBTB48 SIN3A JUNB FOS ZNF398 SP7 SEC11C ENSG00000267215
GH18G059155 0.6 ENCODE 0.4 +15.9 15907 0.2 JUND BHLHE40 SIN3A FOS MAFK NFE2L2 GRP LOC100286992 SEC11C
GH18G059084 1 ENCODE dbSUPER 0.2 -55.1 -55124 0.2 CTCF ZNF654 ETV1 ZSCAN4 TRIM22 ZFP37 ZNF501 RAD21 RFX5 ETV4 ENSG00000267215 SEC11C
GH18G059093 0.4 dbSUPER 0.2 -45.0 -45032 1.9 ZNF7 FOXA1 ENSG00000267215 SEC11C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEC11C on UCSC Golden Path with GeneCards custom track

Promoters for SEC11C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000104073 424 1800 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766

Genomic Location for SEC11C Gene

Chromosome:
18
Start:
59,139,477 bp from pter
End:
59,158,837 bp from pter
Size:
19,361 bases
Orientation:
Plus strand

Genomic View for SEC11C Gene

Genes around SEC11C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC11C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC11C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC11C Gene

Proteins for SEC11C Gene

  • Protein details for SEC11C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY50-SC11C_HUMAN
    Recommended name:
    Signal peptidase complex catalytic subunit SEC11C
    Protein Accession:
    Q9BY50
    Secondary Accessions:
    • B2RAA3

    Protein attributes for SEC11C Gene

    Size:
    192 amino acids
    Molecular mass:
    21542 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

neXtProt entry for SEC11C Gene

Post-translational modifications for SEC11C Gene

  • Ubiquitination at Lys98, Lys122, Lys126, and isoforms=139
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC11C Gene

No data available for DME Specific Peptides for SEC11C Gene

Domains & Families for SEC11C Gene

Suggested Antigen Peptide Sequences for SEC11C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY50

UniProtKB/Swiss-Prot:

SC11C_HUMAN :
  • Belongs to the peptidase S26B family.
Family:
  • Belongs to the peptidase S26B family.
genes like me logo Genes that share domains with SEC11C: view

No data available for Gene Families for SEC11C Gene

Function for SEC11C Gene

Molecular function for SEC11C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
UniProtKB/Swiss-Prot Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SEC11C Gene

Gene Ontology (GO) - Molecular Function for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA,IBA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SEC11C: view
genes like me logo Genes that share phenotypes with SEC11C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEC11C

CRISPR Products

miRNA for SEC11C Gene

miRTarBase miRNAs that target SEC11C

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC11C Gene

Localization for SEC11C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC11C Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC11C gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005787 signal peptidase complex IBA --
GO:0005789 endoplasmic reticulum membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with SEC11C: view

Pathways & Interactions for SEC11C Gene

genes like me logo Genes that share pathways with SEC11C: view

Gene Ontology (GO) - Biological Process for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IBA,IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with SEC11C: view

No data available for SIGNOR curated interactions for SEC11C Gene

Transcripts for SEC11C Gene

Unigene Clusters for SEC11C Gene

SEC11 homolog C (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEC11C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6:

Relevant External Links for SEC11C Gene

GeneLoc Exon Structure for
SEC11C
ECgene alternative splicing isoforms for
SEC11C

Expression for SEC11C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC11C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC11C Gene

This gene is overexpressed in Nasal epithelium (42.3) and Salivary gland (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEC11C Gene



NURSA nuclear receptor signaling pathways regulating expression of SEC11C Gene:

SEC11C

SOURCE GeneReport for Unigene cluster for SEC11C Gene:

Hs.45107

Evidence on tissue expression from TISSUES for SEC11C Gene

  • Pancreas(4.7)
  • Nervous system(4.6)
  • Liver(2.6)
  • Lung(2.4)
  • Spleen(2.1)
  • Kidney(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SEC11C: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC11C Gene

Orthologs for SEC11C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC11C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC11C 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC11C 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC11C 34 35
  • 93.06 (n)
mouse
(Mus musculus)
Mammalia Sec11c 34 16 35
  • 92.19 (n)
cow
(Bos Taurus)
Mammalia SEC11C 34 35
  • 92.01 (n)
rat
(Rattus norvegicus)
Mammalia Sec11c 34
  • 91.15 (n)
oppossum
(Monodelphis domestica)
Mammalia SEC11C 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC11C 34 35
  • 85.69 (n)
lizard
(Anolis carolinensis)
Reptilia SEC11C 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec11c 34
  • 79.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta twr 34 35
  • 67.43 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003069 34
  • 66.08 (n)
worm
(Caenorhabditis elegans)
Secernentea Y54E10BR.5 35
  • 68 (a)
OneToMany
CELE_Y54E10BR.5 34
  • 63.43 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18261g 34
  • 54.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC11 34 35
  • 52.73 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR158W 34
  • 50.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15710 34
  • 61.74 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2895 34
rice
(Oryza sativa)
Liliopsida Os.10990 34
wheat
(Triticum aestivum)
Liliopsida Ta.6431 34
corn
(Zea mays)
Liliopsida Zm.1761 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5539 35
  • 78 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04519 34
  • 56.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec11 34
  • 51.68 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.133 34
Species where no ortholog for SEC11C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • zebrafish (Danio rerio)

Evolution for SEC11C Gene

ENSEMBL:
Gene Tree for SEC11C (if available)
TreeFam:
Gene Tree for SEC11C (if available)

Paralogs for SEC11C Gene

Paralogs for SEC11C Gene

(4) SIMAP similar genes for SEC11C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC11C: view

Variants for SEC11C Gene

Sequence variations from dbSNP and Humsavar for SEC11C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000206906 -- 59,144,801(+) GCAGG(A/T)TTATT intron-variant
rs1000297906 -- 59,150,744(+) AAGGC(C/T)TTTTT intron-variant
rs1000393005 -- 59,150,474(+) GCACA(C/G)TTCTA intron-variant
rs1000429786 -- 59,158,944(+) AGGCT(A/G)TTTAG downstream-variant-500B
rs1000459211 -- 59,157,841(+) TATTT(A/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC11C Gene

Variant ID Type Subtype PubMed ID
esv3304149 CNV mobile element insertion 20981092
esv3402573 CNV insertion 20981092

Variation tolerance for SEC11C Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEC11C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC11C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC11C Gene

Disorders for SEC11C Gene

Relevant External Links for SEC11C

Genetic Association Database (GAD)
SEC11C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEC11C

No disorders were found for SEC11C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC11C Gene

Publications for SEC11C Gene

  1. Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-I+ secretion in gastric cancer. (PMID: 23995782) Oue N. … Yasui W. (Oncogene 2014) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein. (PMID: 2188978) Shelness G.S. … Blobel G. (J. Biol. Chem. 1990) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. (PMID: 26272612) Dai F.F. … Wheeler M.B. (J. Biol. Chem. 2015) 3 64

Products for SEC11C Gene

Sources for SEC11C Gene

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