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Aliases for SEC11C Gene

Aliases for SEC11C Gene

  • SEC11 Homolog C (S. Cerevisiae) 2 3
  • Microsomal Signal Peptidase 21 KDa Subunit 3 4
  • SEC11-Like Protein 3 3 4
  • SPase 21 KDa Subunit 3 4
  • SEC11L3 3 4
  • SPCS4C 3 4
  • SPC21 3 4
  • Signal Peptidase Complex Catalytic Subunit SEC11C 3
  • SEC11-Like 3 (S. Cerevisiae) 2
  • SEC11 Homolog C 4
  • SEC11-Like 3 3
  • EC 3.4.21.89 4

External Ids for SEC11C Gene

Previous HGNC Symbols for SEC11C Gene

  • SEC11L3

Previous GeneCards Identifiers for SEC11C Gene

  • GC18P054960
  • GC18P056807
  • GC18P053515

Summaries for SEC11C Gene

GeneCards Summary for SEC11C Gene

SEC11C (SEC11 Homolog C (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include serine-type peptidase activity. An important paralog of this gene is SEC11A.

UniProtKB/Swiss-Prot for SEC11C Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC11C Gene

Genomics for SEC11C Gene

Regulatory Elements for SEC11C Gene

Genomic Location for SEC11C Gene

Start:
59,139,477 bp from pter
End:
59,158,836 bp from pter
Size:
19,360 bases
Orientation:
Plus strand

Genomic View for SEC11C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC11C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC11C Gene

Proteins for SEC11C Gene

  • Protein details for SEC11C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY50-SC11C_HUMAN
    Recommended name:
    Signal peptidase complex catalytic subunit SEC11C
    Protein Accession:
    Q9BY50
    Secondary Accessions:
    • B2RAA3

    Protein attributes for SEC11C Gene

    Size:
    192 amino acids
    Molecular mass:
    21542 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

neXtProt entry for SEC11C Gene

Proteomics data for SEC11C Gene at MOPED

Post-translational modifications for SEC11C Gene

  • Ubiquitination at Lys98, Lys122, Lys126, and Lys139
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC11C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SEC11C Gene

Domains for SEC11C Gene

Suggested Antigen Peptide Sequences for SEC11C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY50

UniProtKB/Swiss-Prot:

SC11C_HUMAN :
  • Q9BY50
Family:
  • Belongs to the peptidase S26B family.
genes like me logo Genes that share domains with SEC11C: view

No data available for Gene Families for SEC11C Gene

Function for SEC11C Gene

Molecular function for SEC11C Gene

UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins
UniProtKB/Swiss-Prot Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SEC11C Gene

Gene Ontology (GO) - Molecular Function for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with SEC11C: view

miRNA for SEC11C Gene

miRTarBase miRNAs that target SEC11C

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC11C Gene

Localization for SEC11C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC11C Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC11C Gene COMPARTMENTS Subcellular localization image for SEC11C gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEC11C: view

Pathways for SEC11C Gene

genes like me logo Genes that share pathways with SEC11C: view

Pathways by source for SEC11C Gene

Gene Ontology (GO) - Biological Process for SEC11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006465 signal peptide processing IEA --
GO:0006508 proteolysis --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SEC11C: view

Transcripts for SEC11C Gene

Unigene Clusters for SEC11C Gene

SEC11 homolog C (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC11C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6:

Relevant External Links for SEC11C Gene

GeneLoc Exon Structure for
SEC11C
ECgene alternative splicing isoforms for
SEC11C

Expression for SEC11C Gene

mRNA expression in normal human tissues for SEC11C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC11C Gene

SOURCE GeneReport for Unigene cluster for SEC11C Gene Hs.45107

genes like me logo Genes that share expressions with SEC11C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEC11C Gene

Orthologs for SEC11C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC11C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC11C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC11C 35
  • 92.01 (n)
  • 98.44 (a)
SEC11C 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC11C 35
  • 93.06 (n)
  • 98.96 (a)
SEC11C 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec11c 35
  • 92.19 (n)
  • 97.92 (a)
Sec11c 16
Sec11c 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC11C 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC11C 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec11c 35
  • 91.15 (n)
  • 97.4 (a)
chicken
(Gallus gallus)
Aves SEC11C 35
  • 85.69 (n)
  • 94.35 (a)
SEC11C 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC11C 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec11c 35
  • 79.47 (n)
  • 93.79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003069 35
  • 66.08 (n)
  • 75.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta twr 35
  • 67.43 (n)
  • 76 (a)
twr 36
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54E10BR.5 35
  • 63.43 (n)
  • 72 (a)
Y54E10BR.5 36
  • 68 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR158W 35
  • 50.6 (n)
  • 49.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC11 35
  • 52.73 (n)
  • 48.48 (a)
SEC11 36
  • 46 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18261g 35
  • 54.82 (n)
  • 47.59 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15710 35
  • 61.74 (n)
  • 59.17 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2895 35
corn
(Zea mays)
Liliopsida Zm.1761 35
rice
(Oryza sativa)
Liliopsida Os.10990 35
wheat
(Triticum aestivum)
Liliopsida Ta.6431 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04519 35
  • 56.85 (n)
  • 53.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec11 35
  • 51.68 (n)
  • 47.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.133 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5539 36
  • 78 (a)
OneToMany
Species with no ortholog for SEC11C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • zebrafish (Danio rerio)

Evolution for SEC11C Gene

ENSEMBL:
Gene Tree for SEC11C (if available)
TreeFam:
Gene Tree for SEC11C (if available)

Paralogs for SEC11C Gene

Paralogs for SEC11C Gene

Selected SIMAP similar genes for SEC11C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SEC11C: view

Variants for SEC11C Gene

Sequence variations from dbSNP and Humsavar for SEC11C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs938680 -- 59,148,319(-) CGCAA(C/G)AGGGA intron-variant
rs938681 -- 59,148,198(-) ACAAT(C/T)CTGCA intron-variant
rs1130248 -- 59,157,633(+) TGGTC(A/C)CCATA reference, missense, intron-variant
rs1517028 -- 59,143,459(-) CATAA(A/G)TGAAT intron-variant
rs1517029 -- 59,142,346(-) GAACT(C/T)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC11C Gene

Variant ID Type Subtype PubMed ID
nsv909670 CNV Gain 21882294
esv268428 CNV Insertion 20981092

Relevant External Links for SEC11C Gene

HapMap Linkage Disequilibrium report
SEC11C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC11C Gene

Disorders for SEC11C Gene

Relevant External Links for SEC11C

Genetic Association Database (GAD)
SEC11C
genes like me logo Genes that share disorders with SEC11C: view

No data available for UniProtKB/Swiss-Prot for SEC11C Gene

Publications for SEC11C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for SEC11C Gene

Sources for SEC11C Gene

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