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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEC11A Gene

protein-coding   GIFtS: 57
GCID: GC15M085212

SEC11 Homolog A (S. Cerevisiae)

(Previous name: SEC11-like 1 (S. cerevisiae))
(Previous symbol: SEC11L1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SEC11 Homolog A (S. Cerevisiae)1 2     SEC11-Like 1 (S. Cerevisiae)1
SEC11L11 2 3     1810012E07Rik2
Endopeptidase SP182 3     sid28952
Microsomal Signal Peptidase 18 KDa Subunit2 3     Signal Peptidase Complex (18kD)2
SPC182 3     Signal Peptidase Complex Catalytic Subunit SEC11A2
SPCS4A2 3     EC 3.4.21.893
SEC11-Like Protein 12 3     SEC11 Homolog A3
SPase 18 KDa Subunit2 3     

External Ids:    HGNC: 177181   Entrez Gene: 234782   Ensembl: ENSG000001406127   UniProtKB: P678123   

Export aliases for SEC11A gene to outside databases

Previous GC identifer: GC15M083015


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEC11A Gene:
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal
peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis.
Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on
chromosome 8. (provided by RefSeq, Dec 2012)

GeneCards Summary for SEC11A Gene: 
SEC11A (SEC11 homolog A (S. cerevisiae)) is a protein-coding gene. Diseases associated with SEC11A include gastric cancer, and among its related super-pathways are Incretin Synthesis, Secretion, and Inactivation and Viral mRNA Translation. GO annotations related to this gene include serine-type peptidase activity. An important paralog of this gene is SEC11C.

UniProtKB/Swiss-Prot: SC11A_HUMAN, P67812
Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins
as they are translocated into the lumen of the endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEC11A gene promoter:
         STAT1   AP-1   STAT1beta   c-Ets-1   Arnt   STAT1alpha   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC11A promoter sequence
   Search SABiosciences Chromatin IP Primers for SEC11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEC11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.3   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q25.2

SEC11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC11A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M085212:  view genomic region     (about GC identifiers)

Start:
85,212,775 bp from pter      End:
85,259,947 bp from pter
Size:
47,173 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SC11A_HUMAN, P67812 (See protein sequence)
Recommended Name: Signal peptidase complex catalytic subunit SEC11A  
Size: 179 amino acids; 20625 Da
Subunit: Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C,
SPCS1, SPCS2 and SPCS3 (By similarity)
Subcellular location: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic
reticulum membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: B2RAD7 O75957 P21378 Q53FQ8

Explore the universe of human proteins at neXtProt for SEC11A: NX_P67812

Explore proteomics data for SEC11A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P67812

  • SEC11A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEC11A Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001258847.1  NP_001258848.1  NP_001258849.1  NP_001258850.1  NP_001258851.1  NP_055115.1  

    ENSEMBL proteins: 
     ENSP00000452697   ENSP00000452684   ENSP00000268220   ENSP00000453930   ENSP00000413121  
     ENSP00000453997   ENSP00000452932   ENSP00000454193  
    Reactome Protein details: P67812
    Human Recombinant Protein Products for SEC11A: 
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    Novus Biologicals SEC11A Protein
    Novus Biologicals SEC11A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC11A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SEC11A for ontologies           About GeneDecksing



    SEC11A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR019759 Peptidase_S24_S26
     IPR001733 Peptidase_S26B
     IPR015927 Peptidase_S24_S26A/B/C
     IPR011056 Peptidase_S24_S26A/B/C_b-rbn
     IPR019758 Pept_S26A_signal_pept_1_CS

    Graphical View of Domain Structure for InterPro Entry P67812

    ProtoNet protein and cluster: P67812

    2 Blocks protein domains:
    IPB000223 Bacterial leader peptidase 1 (S26) family signature
    IPB001733 Eukaryotic signal peptidase (S27) family signature


    UniProtKB/Swiss-Prot: SC11A_HUMAN, P67812
    Similarity: Belongs to the peptidase S26B family


    SEC11A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC11A_HUMAN, P67812
    Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins
    as they are translocated into the lumen of the endoplasmic reticulum (By similarity)
    Catalytic activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic
    proteins

         Enzyme Number (IUBMB): EC 3.4.21.891

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity ----
    GO:0008236serine-type peptidase activity IEA--
         
    SEC11A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEC11A:
     Increased cell number in G1, s 

         1 MGI phenotypic allele for Sec11a (no phenotypes)

    SEC11A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEC11A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC11A 
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    miRNA
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    miRTarBase miRNAs that target SEC11A:
    hsa-mir-124 (MIRT004120)

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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC11A:
    hsa-miR-141 hsa-miR-4261 hsa-miR-19b hsa-miR-889 hsa-miR-200a hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidSEC11A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEC11A About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.89
    Incretin Synthesis, Secretion, and Inactivation0.89
    Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)0.89
    Synthesis, Secretion, and Deacylation of Ghrelin0.46
    2Viral mRNA Translation
    Translation0.78
    SRP-dependent cotranslational protein targeting to membrane0.77
    3Generic Transcription Pathway
    Gene Expression0.47
    4Insulin Processing
    Peptide hormone metabolism0.39
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/9        Reactome Pathways for SEC11A (see all 9)
        Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Incretin Synthesis, Secretion, and Inactivation
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Synthesis, Secretion, and Deacylation of Ghrelin


    1         Kegg Pathway  (Kegg details for SEC11A):
        Protein export


    SEC11A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEC11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for SEC11A (P678122, 3 ENSP000002682204) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC35F6Q8N3572, 3MINT-64338 I2D: score=4 
    TNFRSF14Q929563, ENSP000003479484I2D: score=2 STRING: ENSP00000347948
    ARF6P623303, ENSP000002983164I2D: score=1 STRING: ENSP00000298316
    EIF1BO607393I2D: score=1 
    HLA-BP304803I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006465signal peptide processing IEA--
    GO:0006508proteolysis IEA--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--

    SEC11A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEC11A (SC11A)

    Search CenterWatch for drugs/clinical trials and news about SEC11A / SC11A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEC11A gene (6 alternative transcripts): 
    NM_001271918.1  NM_001271919.1  NM_001271920.1  NM_001271921.1  NM_001271922.1  NM_014300.3  

    Unigene Cluster for SEC11A:

    SEC11 homolog A (S. cerevisiae)
    Hs.9534  [show with all ESTs]
    Unigene Representative Sequence: CR749656
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559376 ENST00000558134 ENST00000560266 ENST00000268220(uc002blb.1 uc002blc.1)
    ENST00000558217 ENST00000558924 ENST00000455959 ENST00000560409 ENST00000559729
    ENST00000558196
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SEC11A:
    hsa-miR-141 hsa-miR-4261 hsa-miR-19b hsa-miR-889 hsa-miR-200a hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidSEC11A 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC11A
    Sirion Biotech Customized lentivirus for stable overexpression of SEC11A 
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    Primer
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    Additional mRNA sequence: 

    AF061737.1 AF087906.1 AF090315.1 AF108945.1 AK223224.1 AK300693.1 AK314146.1 BC000359.2 
    BC014508.1 CR457127.1 CR749656.1 NR_073518.1 

    17 DOTS entries:

    DT.102828840  DT.418953  DT.100840712  DT.121014038  DT.75177571  DT.100840699  DT.100840709  DT.101987980 
    DT.95081982  DT.99976862  DT.100840700  DT.100840702  DT.101963682  DT.92460461  DT.121014076  DT.92460465 
    DT.40247520 

    24/595 AceView cDNA sequences (see all 595):

    AA044318 BC014508 CR602988 BX114200 CR617421 AA593571 N36435 AA151792 
    CR596388 BM272565 CF242835 AI582279 CR610378 BF984922 BI962836 AA465269 
    N44890 AA044237 BF727377 AA459913 BU786014 BM969997 AI004157 BX279605 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEC11A (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                                -                                                                     
    SP2:                                                        -                                             
    SP3:                                -                       -                                             
    SP4:                                -                 -     -                                             
    SP5:                                -                       -     -                                       


    ECgene alternative splicing isoforms for SEC11A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEC11A expression in normal human tissues (normalized intensities)      SEC11A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACCACAG
    SEC11A Expression
    About this image


    SEC11A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See SEC11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEC11A

    SOURCE GeneReport for Unigene cluster: Hs.9534
        SABiosciences Custom PCR Arrays for SEC11A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC11A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC11A gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec11a1 , 5 SEC11 homolog A (S. cerevisiae)1, 5 90.88(n)1
    99.44(a)1
      7 (45.71 cM)5
    565291  NM_019951.11  NP_064335.11 
     809048895 
    chicken
    (Gallus gallus)
    Aves SEC11A1 SEC11 homolog A (S. cerevisiae) 82.12(n)
    97.77(a)
      415334  NM_001005802.1  NP_001005802.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC11A6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343490.1(205540-213676)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF282622.12   -- 78.98(n)    CF282622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.74722 Transcribed sequence with strong similarity to protein more 80.76(n)    CK361126.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta twr6
    twisted bristles roughened eye
    71(a)
    1 → many
    3R(2483604-2485164)
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.56
    Protein Y54E10BR.5
    67(a)
    1 → many
    I(3028327-3031094)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC11(YIR022W)4
    SEC111
    18kDa catalytic subunit of the Signal Peptidase Complex more4
    Sec11p1
    53.41(n)1
    48.19(a)1
      9(398733-399236)4
    8548401, 4  NP_012288.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G526001 signal peptidase, endoplasmic reticulum-type 60.66(n)
    57.56(a)
      841692  NM_104138.4  NP_175669.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02738001 hypothetical protein 61.88(n)
    58.62(a)
      4340738  NM_001063906.1  NP_001057371.1 


    ENSEMBL Gene Tree for SEC11A (if available)
    TreeFam Gene Tree for SEC11A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEC11A gene
    SEC11C2  
    4 SIMAP similar genes for SEC11A using alignment to 8 protein entries:     SC11A_HUMAN (see all proteins):
    SPC18    SEC11L3    SEC11C    SEC11B

    SEC11A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SEC11A
    PGOHUM00000262016


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/911 SNPs in SEC11A are shown (see all 911)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397521991,2
    --85212333(+) AAAGAC/TGCCAA 7 -- ds50010--------
    rs577534981,2
    C,F--85212485(+) CAACAC/TTAGCT 7 -- ds50012Minor allele frequency- T:0.06WA 120
    rs1872295841,2
    --85212571(+) CTTTTG/TCTTCA 7 -- ds50010--------
    rs2022464191,2
    C--85212612(-) TTTTGC/TGTGTG 7 -- ds50010--------
    rs1908493541,2
    --85212826(+) ACGACC/TACCTC 7 -- ut31 nc-transcript-variant0--------
    rs1162338981,2
    C,F--85213006(+) AAAAAT/ATTGAA 7 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.09WA 118
    rs169744891,2
    C,F,H--85213009(+) AATTTG/CAAAGT 7 -- ut31 nc-transcript-variant8Minor allele frequency- C:0.01NA NS EA 674
    rs1499618381,2
    --85213067(+) GCACTC/GTGTGG 7 -- ut31 nc-transcript-variant0--------
    rs1824773431,2
    C--85213240(+) AGCAAC/GGCAGG 8 A ut31 nc-transcript-variantsyn10--------
    rs2022388741,2
    --85213254(+) CTTACC/TCACGA 12 E G S mis1 ut310--------

    HapMap Linkage Disequilibrium report for SEC11A (85212775 - 85259947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SEC11A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672412CNV Deletion23128226
    esv2672879CNV Deletion23128226
    nsv428310CNV Gain+Loss18775914

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC11A
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC11A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SEC11A:    About MalaCards
    gastric cancer    


    SEC11A for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEC11A

    Export disorders for SEC11A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEC11A gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with SEC11A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23478 HGNC: 17718 AceView: SPC18andNMB Ensembl:ENSG00000140612 euGenes: HUgn23478
    ECgene: SEC11A Kegg: 23478 H-InvDB: SEC11A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEC11A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEC11A gene:
    Search GeneIP for patents involving SEC11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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