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SEC11A Gene

protein-coding   GIFtS: 57
GCID: GC15M085212

SEC11 Homolog A (S. Cerevisiae)

(Previous name: SEC11-like 1 (S. cerevisiae))
(Previous symbol: SEC11L1)
  Search for SEC11A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SEC11 Homolog A (S. Cerevisiae)1 2     SEC11-Like 1 (S. Cerevisiae)1
SEC11L11 2 3     1810012E07Rik2
Endopeptidase SP182 3     sid28952
Microsomal Signal Peptidase 18 KDa Subunit2 3     Signal Peptidase Complex (18kD)2
SPC182 3     Signal Peptidase Complex Catalytic Subunit SEC11A2
SPCS4A2 3     EC 3.4.21.893
SEC11-Like Protein 12 3     SEC11 Homolog A3
SPase 18 KDa Subunit2 3     

External Ids:    HGNC: 177181   Entrez Gene: 234782   Ensembl: ENSG000001406127   UniProtKB: P678123   

Export aliases for SEC11A gene to outside databases

Previous GC identifer: GC15M083015


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEC11A Gene:
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal
peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis.
Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on
chromosome 8. (provided by RefSeq, Dec 2012)

GeneCards Summary for SEC11A Gene:
SEC11A (SEC11 homolog A (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include serine-type peptidase activity. An important paralog of this gene is SEC11C.

UniProtKB/Swiss-Prot: SC11A_HUMAN, P67812
Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins
as they are translocated into the lumen of the endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEC11A gene promoter:
         STAT1   AP-1   STAT1beta   c-Ets-1   Arnt   STAT1alpha   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEC11A promoter sequence
   Search Chromatin IP Primers for SEC11A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEC11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.3   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q25.2

SEC11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEC11A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M085212:  view genomic region     (about GC identifiers)

Start:
85,212,775 bp from pter      End:
85,259,947 bp from pter
Size:
47,173 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SC11A_HUMAN, P67812 (See protein sequence)
Recommended Name: Signal peptidase complex catalytic subunit SEC11A  
Size: 179 amino acids; 20625 Da
Subunit: Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C,
SPCS1, SPCS2 and SPCS3 (By similarity)
Secondary accessions: B2RAD7 O75957 P21378 Q53FQ8

Explore the universe of human proteins at neXtProt for SEC11A: NX_P67812

Explore proteomics data for SEC11A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys114, Lys127
  • Modification sites at PhosphoSitePlus

  • See SEC11A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001258847.1  NP_001258848.1  NP_001258849.1  NP_001258850.1  NP_001258851.1  NP_055115.1  

    ENSEMBL proteins: 
     ENSP00000452697   ENSP00000452684   ENSP00000268220   ENSP00000453930   ENSP00000413121  
     ENSP00000453997   ENSP00000452932   ENSP00000454193  
    Reactome Protein details: P67812

    SEC11A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEC11A
    GenScript Custom Purified and Recombinant Proteins Services for SEC11A
    Novus Biologicals SEC11A Protein
    Novus Biologicals SEC11A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEC11A

     
    Search eBioscience for Proteins for SEC11A 

    SEC11A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Abcam antibodies for SEC11A
    Cloud-Clone Corp. Antibodies for SEC11A
    Search ThermoFisher Antibodies for SEC11A
    LSBio Antibodies in human, mouse, rat for SEC11A

    SEC11A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEC11A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEC11A
    Cloud-Clone Corp. CLIAs for SEC11A
    Search eBioscience for ELISAs for SEC11A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR019759 Peptidase_S24_S26
     IPR001733 Peptidase_S26B
     IPR015927 Peptidase_S24_S26A/B/C
     IPR028360 Peptidase_S24/S26_b-rbn
     IPR019758 Pept_S26A_signal_pept_1_CS

    Graphical View of Domain Structure for InterPro Entry P67812

    ProtoNet protein and cluster: P67812

    2 Blocks protein domains:
    IPB000223 Bacterial leader peptidase 1 (S26) family signature
    IPB001733 Eukaryotic signal peptidase (S27) family signature


    UniProtKB/Swiss-Prot: SC11A_HUMAN, P67812
    Similarity: Belongs to the peptidase S26B family


    Find genes that share domains with SEC11A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SC11A_HUMAN, P67812
    Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins
    as they are translocated into the lumen of the endoplasmic reticulum (By similarity)
    Catalytic activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic
    proteins

         Enzyme Number (IUBMB): EC 3.4.21.891

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity ----
    GO:0008236serine-type peptidase activity IEA--
         
    Find genes that share ontologies with SEC11A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SEC11A:
     Increased cell number in G1, s 

         1 MGI phenotypic allele for Sec11a (no phenotypes)

    Find genes that share phenotypes with SEC11A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEC11A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEC11A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEC11A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEC11A

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEC11A:
    hsa-let-7b-5p (MIRT032228), hsa-mir-16-5p (MIRT031376), hsa-mir-484 (MIRT041796), hsa-mir-30a-5p (MIRT028396), hsa-mir-124-3p (MIRT004120)

    Block miRNA regulation of human, mouse, rat SEC11A using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SEC11A:
    hsa-miR-141 hsa-miR-4261 hsa-miR-19b hsa-miR-889 hsa-miR-200a hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidSEC11A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEC11A
    Predesigned siRNA for gene silencing in human, mouse, rat SEC11A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEC11A

    Clone
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    OriGene clones in human, mouse for SEC11A (see all 7)
    OriGene ORF clones in mouse, rat for SEC11A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC11A (NM_014300)
    Sino Biological Human cDNA Clone for SEC11A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC11A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC11A

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SEC11A
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEC11A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC11A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SC11A_HUMAN, P67812: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic
    reticulum membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SEC11A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEC11A About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Incretin Synthesis, Secretion, and Inactivation
    Incretin Synthesis, Secretion, and Inactivation0.88
    Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)0.00
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.88
    2Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    3Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Synthesis, Secretion, and Deacylation of Ghrelin0.00
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with SEC11A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for SEC11A
        Synthesis, secretion, and deacylation of Ghrelin
    Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    SRP-dependent cotranslational protein targeting to membrane
    Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)


    1 Kegg Pathway  (Kegg details for SEC11A):
        Protein export

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEC11A
    Interactions:

        Search GeneGlobe Interaction Network for SEC11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEC11A (P678122, 3 ENSP000002682204) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC35F6Q8N3572, 3MINT-64338 I2D: score=4 
    TNFRSF14Q929563, ENSP000003479484I2D: score=2 STRING: ENSP00000347948
    ARF6P623303, ENSP000002983164I2D: score=1 STRING: ENSP00000298316
    EIF1BO607393I2D: score=1 
    HLA-BP304803I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006465signal peptide processing IEA--
    GO:0006508proteolysis ----
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with SEC11A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEC11A (SC11A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEC11A gene (6 alternative transcripts): 
    NM_001271918.1  NM_001271919.1  NM_001271920.1  NM_001271921.1  NM_001271922.1  NM_014300.3  

    Unigene Cluster for SEC11A:

    SEC11 homolog A (S. cerevisiae)
    Hs.9534  [show with all ESTs]
    Unigene Representative Sequence: CR749656
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559376 ENST00000558134 ENST00000560266 ENST00000268220(uc002blb.1 uc002blc.1)
    ENST00000558217 ENST00000558924 ENST00000455959 ENST00000560409 ENST00000559729
    ENST00000558196
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate SEC11A:
    hsa-miR-141 hsa-miR-4261 hsa-miR-19b hsa-miR-889 hsa-miR-200a hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidSEC11A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEC11A
    Predesigned siRNA for gene silencing in human, mouse, rat SEC11A
    Clone
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    OriGene clones in human, mouse for SEC11A (see all 7)
    OriGene ORF clones in mouse, rat for SEC11A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEC11A (NM_014300)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEC11A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEC11A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEC11A
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC11A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC11A
      QuantiTect SYBR Green Assays in human, mouse, rat SEC11A
      QuantiFast Probe-based Assays in human, mouse, rat SEC11A

    Additional mRNA sequence: 

    AF061737.1 AF087906.1 AF090315.1 AF108945.1 AK223224.1 AK300693.1 AK314146.1 BC000359.2 
    BC014508.1 CR457127.1 CR749656.1 NR_073518.1 

    17 DOTS entries:

    DT.102828840  DT.418953  DT.100840712  DT.121014038  DT.75177571  DT.100840699  DT.100840709  DT.101987980 
    DT.95081982  DT.99976862  DT.100840700  DT.100840702  DT.101963682  DT.92460461  DT.121014076  DT.92460465 
    DT.40247520 

    Selected AceView cDNA sequences (see all 595):

    AA621876 AA459913 BX377158 AI051931 CA439388 BX425471 N36435 AA044237 
    BM985303 AI880297 BM511320 CR617421 N85136 CB243434 AI265903 BE856409 
    BI908422 AA465156 BQ012897 CF242835 CR620100 BX114200 BM760571 CR592431 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEC11A (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                                -                                                                     
    SP2:                                                        -                                             
    SP3:                                -                       -                                             
    SP4:                                -                 -     -                                             
    SP5:                                -                       -     -                                       


    ECgene alternative splicing isoforms for SEC11A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEC11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACCACAG
    SEC11A Expression
    About this image


    SEC11A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
     
     Amnion (Extraembryonic Tissues)
    SEC11A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEC11A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9534
        Custom PCR Arrays for SEC11A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEC11A
    OriGene qSTAR qPCR primer pairs in human, mouse for SEC11A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEC11A
    QuantiTect SYBR Green Assays in human, mouse, rat SEC11A
    QuantiFast Probe-based Assays in human, mouse, rat SEC11A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEC11A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEC11A gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sec11a1 , 5 SEC11 homolog A (S. cerevisiae)1, 5 90.88(n)1
    99.44(a)1
      7 (45.71 cM)5
    565291  NM_019951.11  NP_064335.11 
     809048895 
    chicken
    (Gallus gallus)
    Aves SEC11A1 SEC11 homolog A (S. cerevisiae) 82.12(n)
    97.77(a)
      415334  NM_001005802.1  NP_001005802.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEC11A6
    SEC11 homolog A (S. cerevisiae)
    82(a)
    1 ↔ 1
    GL343490.1(205540-213676)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF282622.12   -- 78.98(n)    CF282622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.74722 Transcribed sequence with strong similarity to protein more 80.76(n)    CK361126.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta twr6
    twisted bristles roughened eye
    72(a)
    1 → many
    3R(2483604-2485164)
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.56
    Protein Y54E10BR.5 (Y54E10BR.5) mRNA, complete cds...
    67(a)
    1 → many
    I(3028327-3031092) WBGene00021844
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC11(YIR022W)4 18kDa catalytic subunit of the Signal Peptidase Complex more   --   9(398733-399236) 854840  NP_012288.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G526001 AT1G52600 62.47(n)
    59.75(a)
      841692  NM_104138.4  NP_175669.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02738001 Os06g0273800 63.94(n)
    61.01(a)
      4340738  NM_001063906.1  NP_001057371.1 


    ENSEMBL Gene Tree for SEC11A (if available)
    TreeFam Gene Tree for SEC11A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEC11A gene
    SEC11C2  
    4 SIMAP similar genes for SEC11A using alignment to 8 protein entries:     SC11A_HUMAN (see all proteins):
    SPC18    SEC11L3    SEC11C    SEC11B

    Find genes that share paralogs with SEC11A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SEC11A
    PGOHUM00000262016


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEC11A (see all 911)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397521991,2
    --85212333(+) AAAGAC/TGCCAA 7 -- ds50010--------
    rs577534981,2
    C,F--85212485(+) CAACAC/TTAGCT 7 -- ds50012Minor allele frequency- T:0.06WA 120
    rs1872295841,2
    --85212571(+) CTTTTG/TCTTCA 7 -- ds50010--------
    rs2022464191,2
    C--85212612(-) TTTTGC/TGTGTG 7 -- ds50010--------
    rs1908493541,2
    --85212826(+) ACGACC/TACCTC 7 -- ut31 nc-transcript-variant0--------
    rs1162338981,2
    C,F--85213006(+) AAAAAT/ATTGAA 7 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.09WA 118
    rs169744891,2
    C,F,H--85213009(+) AATTTG/CAAAGT 7 -- ut31 nc-transcript-variant8Minor allele frequency- C:0.01NA NS EA 674
    rs1499618381,2
    --85213067(+) GCACTC/GTGTGG 7 -- ut31 nc-transcript-variant0--------
    rs1824773431,2
    C--85213240(+) AGCAAC/GGCAGG 8 A ut31 nc-transcript-variantsyn10--------
    rs2022388741,2
    --85213254(+) CTTACC/TCACGA 12 E G S mis1 ut310--------

    HapMap Linkage Disequilibrium report for SEC11A (85212775 - 85259947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SEC11A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672412CNV Deletion23128226
    esv2672879CNV Deletion23128226
    nsv428310CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEC11A
    DNA2.0 Custom Variant and Variant Library Synthesis for SEC11A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SEC11A           About GenesLikeMe

    Genetic Association Database (GAD): SEC11A

    Export disorders for SEC11A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEC11A gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with SEC11A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (Mol. Cell. Biochem. 2012)
    4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23478 HGNC: 17718 AceView: SPC18andNMB Ensembl:ENSG00000140612 euGenes: HUgn23478
    ECgene: SEC11A Kegg: 23478 H-InvDB: SEC11A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SEC11A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SEC11A gene:
    Search GeneIP for patents involving SEC11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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