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Aliases for SEC11A Gene

Aliases for SEC11A Gene

  • SEC11 Homolog A (S. Cerevisiae) 2 3
  • Microsomal Signal Peptidase 18 KDa Subunit 3 4
  • SEC11-Like Protein 1 3 4
  • SPase 18 KDa Subunit 3 4
  • Endopeptidase SP18 3 4
  • SEC11L1 3 4
  • SPCS4A 3 4
  • SPC18 3 4
  • Signal Peptidase Complex Catalytic Subunit SEC11A 3
  • Signal Peptidase Complex (18kD) 3
  • SEC11-Like 1 (S. Cerevisiae) 2
  • SEC11 Homolog A 4
  • 1810012E07Rik 3
  • EC 3.4.21.89 4
  • Sid2895 3

External Ids for SEC11A Gene

Previous Symbols for SEC11A Gene

  • SEC11L1

Summaries for SEC11A Gene

Entrez Gene Summary for SEC11A Gene

  • This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]

GeneCards Summary for SEC11A Gene

SEC11A (SEC11 Homolog A (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include serine-type peptidase activity. An important paralog of this gene is SEC11C.

UniProtKB/Swiss-Prot for SEC11A Gene

  • Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC11A Gene

Genomics for SEC11A Gene

Genomic Location for SEC11A Gene

Start:
84,669,537 bp from pter
End:
84,716,716 bp from pter
Size:
47,180 bases
Orientation:
Minus strand

Genomic View for SEC11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEC11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC11A Gene

Regulatory Elements for SEC11A Gene

Proteins for SEC11A Gene

  • Protein details for SEC11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67812-SC11A_HUMAN
    Recommended name:
    Signal peptidase complex catalytic subunit SEC11A
    Protein Accession:
    P67812
    Secondary Accessions:
    • B2RAD7
    • B4DUL4
    • H0YK72
    • H0YK83
    • O75957
    • P21378
    • Q53FQ8

    Protein attributes for SEC11A Gene

    Size:
    179 amino acids
    Molecular mass:
    20625 Da
    Quaternary structure:
    • Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

    Alternative splice isoforms for SEC11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEC11A Gene

Proteomics data for SEC11A Gene at MOPED

Post-translational modifications for SEC11A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys114 and Lys127

No data available for DME Specific Peptides for SEC11A Gene

Domains for SEC11A Gene

UniProtKB/Swiss-Prot:

SC11A_HUMAN
Family:
  • Belongs to the peptidase S26B family.:
    • P67812
genes like me logo Genes that share domains with SEC11A: view

No data available for Gene Families for SEC11A Gene

Function for SEC11A Gene

Molecular function for SEC11A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins
UniProtKB/Swiss-Prot Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for SEC11A Gene

Gene Ontology (GO) - Molecular Function for SEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with SEC11A: view

Phenotypes for SEC11A Gene

GenomeRNAi human phenotypes for SEC11A:
genes like me logo Genes that share phenotypes with SEC11A: view

miRNA for SEC11A Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SEC11A Gene

Localization for SEC11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC11A Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEC11A Gene COMPARTMENTS Subcellular localization image for SEC11A gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SEC11A: view

Pathways for SEC11A Gene

genes like me logo Genes that share pathways with SEC11A: view

Pathways by source for SEC11A Gene

Gene Ontology (GO) - Biological Process for SEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006465 signal peptide processing IEA --
GO:0006508 proteolysis --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SEC11A: view

Transcripts for SEC11A Gene

Unigene Clusters for SEC11A Gene

SEC11 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEC11A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -

Relevant External Links for SEC11A Gene

GeneLoc Exon Structure for
SEC11A
ECgene alternative splicing isoforms for
SEC11A

Expression for SEC11A Gene

mRNA expression in normal human tissues for SEC11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEC11A Gene

SOURCE GeneReport for Unigene cluster for SEC11A Gene Hs.9534

genes like me logo Genes that share expressions with SEC11A: view

Orthologs for SEC11A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEC11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC11A 36
  • 99.63 (n)
  • 100 (a)
SEC11A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEC11A 36
  • 97.02 (n)
  • 100 (a)
SEC11A 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEC11A 36
  • 95.34 (n)
  • 100 (a)
SEC11A 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sec11a 36
  • 90.88 (n)
  • 99.44 (a)
Sec11a 16
Sec11a 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEC11A 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC11A 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec11a 36
  • 90.32 (n)
  • 99.44 (a)
chicken
(Gallus gallus)
Aves SEC11A 36
  • 82.12 (n)
  • 97.77 (a)
SEC11A 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC11A 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76332 36
sec11a 36
  • 78.77 (n)
  • 97.21 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.7472 36
sec11a 36
  • 80.45 (n)
  • 96.65 (a)
sec11a 37
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta twr 37
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54E10BR.5 37
  • 67 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC11 37
  • 46 (a)
OneToMany
SEC11 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G52600 36
  • 62.47 (n)
  • 59.75 (a)
rice
(Oryza sativa)
Liliopsida Os06g0273800 36
  • 63.94 (n)
  • 61.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5539 37
  • 76 (a)
OneToMany
Species with no ortholog for SEC11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC11A Gene

ENSEMBL:
Gene Tree for SEC11A (if available)
TreeFam:
Gene Tree for SEC11A (if available)

Paralogs for SEC11A Gene

Paralogs for SEC11A Gene

Selected SIMAP similar genes for SEC11A Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for SEC11A Gene

genes like me logo Genes that share paralogs with SEC11A: view

Variants for SEC11A Gene

Sequence variations from dbSNP and Humsavar for SEC11A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs921094 -- 84,706,791(+) CAAAT(C/G)CCCTT intron-variant
rs1268453 -- 84,712,078(+) tctac(A/T)aaaaa intron-variant
rs1984829 -- 84,708,482(-) TAATA(G/T)GAATA intron-variant
rs2218577 -- 84,674,046(+) ACAAT(C/T)TTAGT intron-variant
rs4280214 -- 84,673,033(+) cagcc(A/G)cccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEC11A Gene

Variant ID Type Subtype PubMed ID
nsv428310 CNV Gain+Loss 18775914
esv2672879 CNV Deletion 23128226
esv2672412 CNV Deletion 23128226

Relevant External Links for SEC11A Gene

HapMap Linkage Disequilibrium report
SEC11A

Disorders for SEC11A Gene

Relevant External Links for SEC11A

Genetic Association Database (GAD)
SEC11A
genes like me logo Genes that share disorders with SEC11A: view

No data available for UniProtKB/Swiss-Prot for SEC11A Gene

Publications for SEC11A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  5. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PMID: 18781797) Meierhofer D. … Kaiser P. (J. Proteome Res. 2008) 3

Products for SEC11A Gene

Sources for SEC11A Gene

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