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Aliases for SEBOX Gene

Aliases for SEBOX Gene

  • SEBOX Homeobox 2 3 5
  • Skin-, Embryo-, Brain- And Oocyte-Specific Homeobox 3 4
  • Homeobox OG-9 3 4
  • OG9X 3 4
  • OG-9 3
  • OG9 3

External Ids for SEBOX Gene

Previous GeneCards Identifiers for SEBOX Gene

  • GC17M023716
  • GC17M026691
  • GC17M028367
  • GC17M028456

Summaries for SEBOX Gene

Entrez Gene Summary for SEBOX Gene

  • Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SEBOX Gene

SEBOX (SEBOX Homeobox) is a Protein Coding gene. An important paralog of this gene is PITX3.

UniProtKB/Swiss-Prot for SEBOX Gene

  • Probable transcription factor involved in the control of specification of mesoderm and endoderm.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEBOX Gene

Genomics for SEBOX Gene

Regulatory Elements for SEBOX Gene

Genomic Location for SEBOX Gene

28,364,268 bp from pter
28,365,244 bp from pter
977 bases
Minus strand

Genomic View for SEBOX Gene

Genes around SEBOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEBOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEBOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEBOX Gene

Proteins for SEBOX Gene

  • Protein details for SEBOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein SEBOX
    Protein Accession:

    Protein attributes for SEBOX Gene

    216 amino acids
    Molecular mass:
    22879 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG14458.1; Type=Frameshift; Positions=9; Evidence={ECO:0000305}; Sequence=EAW51081.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SEBOX Gene

Proteomics data for SEBOX Gene at MOPED

Post-translational modifications for SEBOX Gene

No Post-translational modifications

Other Protein References for SEBOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEBOX Gene

Domains & Families for SEBOX Gene

Gene Families for SEBOX Gene

Protein Domains for SEBOX Gene


Suggested Antigen Peptide Sequences for SEBOX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with SEBOX: view

Function for SEBOX Gene

Molecular function for SEBOX Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in the control of specification of mesoderm and endoderm.

Phenotypes for SEBOX Gene

MGI mutant phenotypes for SEBOX:
inferred from 1 alleles
GenomeRNAi human phenotypes for SEBOX:
genes like me logo Genes that share phenotypes with SEBOX: view

Animal Models for SEBOX Gene

MGI Knock Outs for SEBOX:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SEBOX Gene

Localization for SEBOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEBOX Gene

Subcellular locations from

Jensen Localization Image for SEBOX Gene COMPARTMENTS Subcellular localization image for SEBOX gene
Compartment Confidence
extracellular 3
nucleus 3
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SEBOX Gene

Pathways & Interactions for SEBOX Gene

SuperPathways for SEBOX Gene

No Data Available

Interacting Proteins for SEBOX Gene

Gene Ontology (GO) - Biological Process for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SEBOX: view

No data available for Pathways by source and SIGNOR curated interactions for SEBOX Gene

Drugs & Compounds for SEBOX Gene

No Compound Related Data Available

Transcripts for SEBOX Gene

mRNA/cDNA for SEBOX Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SEBOX Gene

No ASD Table

Relevant External Links for SEBOX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEBOX Gene

mRNA expression in normal human tissues for SEBOX Gene

mRNA expression in normal human tissues for SEBOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SEBOX Gene Hs.728714

genes like me logo Genes that share expression patterns with SEBOX: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SEBOX Gene

Orthologs for SEBOX Gene

This gene was present in the common ancestor of mammals.

Orthologs for SEBOX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEBOX 35
  • 82.3 (n)
  • 72.32 (a)
(Canis familiaris)
Mammalia SEBOX 35
  • 83.95 (n)
  • 72.49 (a)
(Mus musculus)
Mammalia Sebox 35
  • 75 (n)
  • 63.3 (a)
Sebox 16
(Pan troglodytes)
Mammalia SEBOX 35
  • 97.96 (n)
  • 94.81 (a)
(Rattus norvegicus)
Mammalia Sebox 35
  • 74.51 (n)
  • 64.71 (a)
Species with no ortholog for SEBOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEBOX Gene

Gene Tree for SEBOX (if available)
Gene Tree for SEBOX (if available)

Paralogs for SEBOX Gene

Paralogs for SEBOX Gene

(3) SIMAP similar genes for SEBOX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SEBOX: view

Variants for SEBOX Gene

Sequence variations from dbSNP and Humsavar for SEBOX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9910163 - 28,364,299(+) TGGCC(A/G)AGGCA reference, missense
rs2227732 -- 28,366,697(-) GCACA(C/T)ACTTC upstream-variant-2KB
rs2227733 -- 28,366,596(-) ACTCT(A/G)TCTCT upstream-variant-2KB
rs2227734 -- 28,366,377(-) AGCTA(C/T)TTAGG upstream-variant-2KB
rs2227735 -- 28,366,237(-) cctgt(A/G)gtccc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEBOX Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680

Variation tolerance for SEBOX Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEBOX Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEBOX Gene

Disorders for SEBOX Gene

Relevant External Links for SEBOX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEBOX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEBOX Gene

Publications for SEBOX Gene

  1. Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. (PMID: 10922053) Cinquanta M. … Nirenberg M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 67
  2. Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. (PMID: 25080503) Kwan J.S. … Kung A.W. (Hum. Mol. Genet. 2014) 3
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for SEBOX Gene

Sources for SEBOX Gene

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