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Aliases for SEBOX Gene

Aliases for SEBOX Gene

  • SEBOX Homeobox 2 3
  • Skin-, Embryo-, Brain- And Oocyte-Specific Homeobox 3 4
  • Homeobox OG-9 3 4
  • OG9X 3 4
  • OG-9 3
  • OG9 3

External Ids for SEBOX Gene

Previous GeneCards Identifiers for SEBOX Gene

  • GC17M023716
  • GC17M026691
  • GC17M028367

Summaries for SEBOX Gene

Entrez Gene Summary for SEBOX Gene

  • Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SEBOX Gene

SEBOX (SEBOX Homeobox) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SEBOX Gene

  • Probable transcription factor involved in the control of specification of mesoderm and endoderm.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEBOX Gene

Genomics for SEBOX Gene

Regulatory Elements for SEBOX Gene

Genomic Location for SEBOX Gene

Chromosome:
17
Start:
28,364,268 bp from pter
End:
28,365,244 bp from pter
Size:
977 bases
Orientation:
Minus strand

Genomic View for SEBOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEBOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEBOX Gene

Proteins for SEBOX Gene

  • Protein details for SEBOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB31-SEBOX_HUMAN
    Recommended name:
    Homeobox protein SEBOX
    Protein Accession:
    Q9HB31

    Protein attributes for SEBOX Gene

    Size:
    216 amino acids
    Molecular mass:
    22879 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG14458.1; Type=Frameshift; Positions=9; Evidence={ECO:0000305}; Sequence=EAW51081.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SEBOX Gene

Proteomics data for SEBOX Gene at MOPED

Post-translational modifications for SEBOX Gene

No Post-translational modifications

Other Protein References for SEBOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEBOX Gene

Domains & Families for SEBOX Gene

Gene Families for SEBOX Gene

Protein Domains for SEBOX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SEBOX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB31

UniProtKB/Swiss-Prot:

SEBOX_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with SEBOX: view

Function for SEBOX Gene

Molecular function for SEBOX Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in the control of specification of mesoderm and endoderm.

Gene Ontology (GO) - Molecular Function for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with SEBOX: view

Phenotypes for SEBOX Gene

MGI mutant phenotypes for SEBOX:
inferred from 1 alleles
GenomeRNAi human phenotypes for SEBOX:
genes like me logo Genes that share phenotypes with SEBOX: view

Animal Models for SEBOX Gene

MGI Knock Outs for SEBOX:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEBOX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SEBOX Gene

Localization for SEBOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEBOX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEBOX Gene COMPARTMENTS Subcellular localization image for SEBOX gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SEBOX: view

Pathways & Interactions for SEBOX Gene

SuperPathways for SEBOX Gene

No Data Available

Interacting Proteins for SEBOX Gene

Gene Ontology (GO) - Biological Process for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0008150 biological_process ND --
GO:0009792 embryo development ending in birth or egg hatching --
genes like me logo Genes that share ontologies with SEBOX: view

No data available for Pathways by source and SIGNOR curated interactions for SEBOX Gene

Drugs & Compounds for SEBOX Gene

No Compound Related Data Available

Transcripts for SEBOX Gene

mRNA/cDNA for SEBOX Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEBOX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEBOX Gene

No ASD Table

Relevant External Links for SEBOX Gene

GeneLoc Exon Structure for
SEBOX
ECgene alternative splicing isoforms for
SEBOX

Expression for SEBOX Gene

mRNA expression in normal human tissues for SEBOX Gene

mRNA expression in normal human tissues for SEBOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SEBOX Gene Hs.728714

genes like me logo Genes that share expression patterns with SEBOX: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SEBOX Gene

Orthologs for SEBOX Gene

This gene was present in the common ancestor of mammals.

Orthologs for SEBOX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEBOX 35
  • 82.3 (n)
  • 72.32 (a)
dog
(Canis familiaris)
Mammalia SEBOX 35
  • 83.95 (n)
  • 72.49 (a)
mouse
(Mus musculus)
Mammalia Sebox 35
  • 75 (n)
  • 63.3 (a)
Sebox 16
chimpanzee
(Pan troglodytes)
Mammalia SEBOX 35
  • 97.96 (n)
  • 94.81 (a)
rat
(Rattus norvegicus)
Mammalia Sebox 35
  • 74.51 (n)
  • 64.71 (a)
Species with no ortholog for SEBOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEBOX Gene

ENSEMBL:
Gene Tree for SEBOX (if available)
TreeFam:
Gene Tree for SEBOX (if available)

Paralogs for SEBOX Gene

(3) SIMAP similar genes for SEBOX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SEBOX: view

No data available for Paralogs for SEBOX Gene

Variants for SEBOX Gene

Sequence variations from dbSNP and Humsavar for SEBOX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2227735 -- 28,366,237(-) cctgt(A/G)gtccc upstream-variant-2KB
rs2227736 -- 28,366,210(-) aaggc(C/G)cgtgg upstream-variant-2KB
rs2227738 -- 28,366,191(-) gttag(A/G)agttc upstream-variant-2KB
rs2277667 -- 28,364,894(-) CAGCT(A/G)CTGGA reference, synonymous-codon
rs2277668 -- 28,364,738(-) CCCTT(C/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEBOX Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680

Variation tolerance for SEBOX Gene

Residual Variation Intolerance Score: 94.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEBOX Gene

HapMap Linkage Disequilibrium report
SEBOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEBOX Gene

Disorders for SEBOX Gene

Relevant External Links for SEBOX

Genetic Association Database (GAD)
SEBOX
Human Genome Epidemiology (HuGE) Navigator
SEBOX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEBOX
genes like me logo Genes that share disorders with SEBOX: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEBOX Gene

Publications for SEBOX Gene

  1. Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. (PMID: 10922053) Cinquanta M. … Nirenberg M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 67
  2. Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. (PMID: 25080503) Kwan J.S. … Kung A.W. (Hum. Mol. Genet. 2014) 67
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 67
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 67
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 67

Products for SEBOX Gene

Sources for SEBOX Gene

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