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Aliases for SEBOX Gene

Aliases for SEBOX Gene

  • SEBOX Homeobox 2 3
  • Skin-, Embryo-, Brain- And Oocyte-Specific Homeobox 3 4
  • Homeobox OG-9 3 4
  • OG9X 3 4
  • OG9 3 6
  • Homeobox Protein SEBOX 3
  • OG-9 3

External Ids for SEBOX Gene

Previous GeneCards Identifiers for SEBOX Gene

  • GC17M023716
  • GC17M026691

Summaries for SEBOX Gene

Entrez Gene Summary for SEBOX Gene

  • Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SEBOX Gene

SEBOX (SEBOX Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SEBOX Gene

  • Probable transcription factor involved in the control of specification of mesoderm and endoderm.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEBOX Gene

Genomics for SEBOX Gene

Regulatory Elements for SEBOX Gene

Genomic Location for SEBOX Gene

28,364,268 bp from pter
28,365,244 bp from pter
977 bases
Minus strand

Genomic View for SEBOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEBOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEBOX Gene

Proteins for SEBOX Gene

  • Protein details for SEBOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein SEBOX
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SEBOX Gene

    216 amino acids
    Molecular mass:
    22879 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG14458.1; Type=Frameshift; Positions=9; Evidence={ECO:0000305}; Sequence=EAW51081.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SEBOX Gene

Proteomics data for SEBOX Gene at MOPED

Post-translational modifications for SEBOX Gene

No Post-translational modifications

Other Protein References for SEBOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEBOX Gene

Domains for SEBOX Gene

Gene Families for SEBOX Gene

  • PRD :Homeoboxes / PRD class

Protein Domains for SEBOX Gene


Suggested Antigen Peptide Sequences for SEBOX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9HB31
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with SEBOX: view

Function for SEBOX Gene

Molecular function for SEBOX Gene

UniProtKB/Swiss-Prot Function: Probable transcription factor involved in the control of specification of mesoderm and endoderm.

Gene Ontology (GO) - Molecular Function for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with SEBOX: view

Phenotypes for SEBOX Gene

MGI mutant phenotypes for SEBOX:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SEBOX: view

Animal Models for SEBOX Gene

MGI Knock Outs for SEBOX:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SEBOX Gene

Localization for SEBOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEBOX Gene

Subcellular locations from

Jensen Localization Image for SEBOX Gene COMPARTMENTS Subcellular localization image for SEBOX gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SEBOX: view

Pathways for SEBOX Gene

SuperPathways for SEBOX Gene

No Data Available

Interacting Proteins for SEBOX Gene

Gene Ontology (GO) - Biological Process for SEBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development --
GO:0008150 biological_process ND --
GO:0009792 embryo development ending in birth or egg hatching IEA --
genes like me logo Genes that share ontologies with SEBOX: view

No data available for Pathways by source for SEBOX Gene

Transcripts for SEBOX Gene

mRNA/cDNA for SEBOX Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEBOX

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEBOX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEBOX Gene

No ASD Table

Relevant External Links for SEBOX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEBOX Gene

mRNA expression in normal human tissues for SEBOX Gene

mRNA expression in normal human tissues for SEBOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SEBOX Gene Hs.728714

genes like me logo Genes that share expressions with SEBOX: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for SEBOX Gene

Orthologs for SEBOX Gene

This gene was present in the common ancestor of mammals.

Orthologs for SEBOX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEBOX 35
  • 97.96 (n)
  • 94.81 (a)
(Bos Taurus)
Mammalia SEBOX 35
  • 82.3 (n)
  • 72.32 (a)
(Canis familiaris)
Mammalia SEBOX 35
  • 83.95 (n)
  • 72.49 (a)
(Mus musculus)
Mammalia Sebox 35
  • 75 (n)
  • 63.3 (a)
Sebox 16
(Rattus norvegicus)
Mammalia Sebox 35
  • 74.51 (n)
  • 64.71 (a)
Species with no ortholog for SEBOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEBOX Gene

Gene Tree for SEBOX (if available)
Gene Tree for SEBOX (if available)

Paralogs for SEBOX Gene

Selected SIMAP similar genes for SEBOX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SEBOX: view

No data available for Paralogs for SEBOX Gene

Variants for SEBOX Gene

Sequence variations from dbSNP and Humsavar for SEBOX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2227732 -- 28,366,697(-) GCACA(C/T)ACTTC upstream-variant-2KB
rs2227733 -- 28,366,596(-) ACTCT(A/G)TCTCT upstream-variant-2KB
rs2227734 -- 28,366,377(-) AGCTA(C/T)TTAGG upstream-variant-2KB
rs2227735 -- 28,366,237(-) cctgt(A/G)gtccc upstream-variant-2KB
rs2227736 -- 28,366,210(-) aaggc(C/G)cgtgg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEBOX Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680

Relevant External Links for SEBOX Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEBOX Gene

Disorders for SEBOX Gene

(2) University of Copenhagen DISEASES for SEBOX Gene

Relevant External Links for SEBOX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SEBOX: view

No data available for UniProtKB/Swiss-Prot for SEBOX Gene

Publications for SEBOX Gene

  1. Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. (PMID: 10922053) Cinquanta M. … Nirenberg M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for SEBOX Gene

Sources for SEBOX Gene

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