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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SDSL Gene

protein-coding   GIFtS: 56
GCID: GC12P113860

Serine Dehydratase-Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine Dehydratase-Like1 2     SDH 22 3
Serine Dehydratase 22 3     SDH2
TDH2 3     SDS-RS12
L-Serine Deaminase2 3     Serine Dehydratase Related Sequence 12
L-Serine Dehydratase/L-Threonine Deaminase2 3     EC 4.3.1.173
L-Threonine Dehydratase2 3     EC 4.3.1.193

External Ids:    HGNC: 304041   Entrez Gene: 1136752   Ensembl: ENSG000001394107   UniProtKB: Q96GA73   

Export aliases for SDSL gene to outside databases

Previous GC identifers: GC12P112273 GC12P112322 GC12P110871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SDSL Gene: 
SDSL (serine dehydratase-like) is a protein-coding gene. Diseases associated with SDSL include schizoaffective disorder. GO annotations related to this gene include L-serine ammonia-lyase activity and molecular_function. An important paralog of this gene is SDS.

UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7
Function: Has low serine dehydratase and threonine dehydratase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SDSL gene promoter:
         TBP   MAZR   ATF-2   Tal-1beta   PPAR-alpha   PPAR-gamma1   c-Jun   PPAR-gamma2   ITF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDSL promoter sequence
   Search SABiosciences Chromatin IP Primers for SDSL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDSL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.21

SDSL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDSL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113860:  view genomic region     (about GC identifiers)

Start:
113,860,042 bp from pter      End:
113,876,081 bp from pter
Size:
16,040 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7 (See protein sequence)
Recommended Name: Serine dehydratase-like  
Size: 329 amino acids; 34674 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer (Probable)
1 PDB 3D structure from and Proteopedia for SDSL:
2RKB (3D)    

Explore the universe of human proteins at neXtProt for SDSL: NX_Q96GA7

Explore proteomics data for SDSL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GA7

  • SDSL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SDSL Protein Expression
    REFSEQ proteins: NP_612441.1  
    ENSEMBL proteins: 
     ENSP00000385790   ENSP00000448868   ENSP00000341117   ENSP00000446867   ENSP00000449136  
     ENSP00000448950  

    Human Recombinant Protein Products for SDSL: 
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    OriGene MassSpec for SDSL 
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    Novus Biologicals SDSL Proteins
    Novus Biologicals SDSL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SDSL
    Cloud-Clone Corp. Proteins for SDSL 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--

    SDSL for ontologies           About GeneDecksing



    SDSL Antibody Products: 
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    Cloud-Clone Corp. Antibodies for SDSL 
    Search ThermoFisher Antibodies for SDSL
    LSBio Antibodies in human, mouse, rat for SDSL 

    Assay Products for SDSL: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SDSL 
    Cloud-Clone Corp. CLIAs for SDSL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF

    Graphical View of Domain Structure for InterPro Entry Q96GA7

    ProtoNet protein and cluster: Q96GA7

    2 Blocks protein domains:
    IPB000634 Serine/threonine dehydratase
    IPB001926 Pyridoxal-5'-phosphate-dependent enzyme


    UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7
    Similarity: Belongs to the serine/threonine dehydratase family


    SDSL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDSL_HUMAN, Q96GA7
    Function: Has low serine dehydratase and threonine dehydratase activity
    Catalytic activity: L-serine = pyruvate + NH(3)
    Catalytic activity: L-threonine = 2-oxobutanoate + NH(3)
    Biophysicochemical properties: Kinetic parameters: KM=30 mM for serine; KM=7 mM for threonine;

         Enzyme Numbers (IUBMB): EC 4.3.1.171 EC 4.3.1.191

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003941L-serine ammonia-lyase activity IEA--
    GO:0004794L-threonine ammonia-lyase activity IEA--
    GO:0030170pyridoxal phosphate binding IEA--
         
    SDSL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SDSL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SDSL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SDSL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SDSL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDSL
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SDSL
    SwitchGear 3'UTR luciferase reporter plasmidSDSL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SDSL

    Clone
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    OriGene clones in human, mouse for SDSL (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SDSL (NM_138432)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDSL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDSL
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                         Customized lentivirus expression plasmids for stable overexpression of SDSL 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDSL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SDSL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1glycine betaine degradation
    glycine betaine degradation
    2L-serine degradation
    L-serine degradation


    2 BioSystems Pathways for SDSL
        glycine betaine degradation
    L-serine degradation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDSL

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for SDSL (Q96GA72, 3 ENSP000003411174) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TUBGCP4Q9UGJ12, 3, ENSP000002603834MINT-66914 I2D: score=4 STRING: ENSP00000260383
    SDSLQ96GA72MINT-66506
    SHMT1ENSP000003188684STRING: ENSP00000318868
    SHMT2ENSP000003336674STRING: ENSP00000333667
    SDAD1ENSP000003485964STRING: ENSP00000348596
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process IEA--
    GO:0008150biological_process ND--

    SDSL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SDSL

    1 HMDB Compound for SDSL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    1 DrugBank Compound for SDSL    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about SDSL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SDSL gene: 
    NM_138432.2  

    Unigene Cluster for SDSL:

    Serine dehydratase-like
    Hs.337594  [show with all ESTs]
    Unigene Representative Sequence: BC009849
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403593(uc009zwh.3) ENST00000553248 ENST00000345635(uc001tvi.3)
    ENST00000547802 ENST00000546672 ENST00000551760
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDSL
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SDSL
    SwitchGear 3'UTR luciferase reporter plasmidSDSL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SDSL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDSL
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    OriGene ORF clones in mouse, rat for SDSL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SDSL (NM_138432)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDSL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDSL
    Sirion Biotech Customized lentivirus for stable overexpression of SDSL 
                         Customized lentivirus expression plasmids for stable overexpression of SDSL 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SDSL
    OriGene qSTAR qPCR primer pairs in human, mouse for SDSL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDSL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDSL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDSL

    Additional mRNA sequence: 

    AF134473.1 BC009849.2 BC091479.1 

    4 DOTS entries:

    DT.101977468  DT.100714735  DT.40204959  DT.121186756 

    24/64 AceView cDNA sequences (see all 64):

    BX092907 CK819531 BF064129 AI971693 CA432646 CB988193 BG679339 BE222929 
    BU902368 CB960840 C16636 BU543274 BG473546 AW613258 BQ951062 BC009849 
    BU542644 AF134473 BG749122 BU540522 BU845952 BM129278 BQ951402 BG774012 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SDSL (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
    SP1:              -                                                                 -               
    SP2:              -     -                                                           -               
    SP3:              -     -     -     -                                                               
    SP4:                                            -                                   -               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SDSL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SDSL expression in normal human tissues (normalized intensities)      SDSL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGTCCTG
    SDSL Expression
    About this image


    SDSL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             monocyte-derived macrophage   
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Lung (Respiratory System)
             alveolar macrophages   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See SDSL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SDSL

    SOURCE GeneReport for Unigene cluster: Hs.337594
        SABiosciences Custom PCR Arrays for SDSL
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SDSL gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdsl1 , 5 serine dehydratase-like1, 5 81.14(n)1
    81.04(a)1
      5 (60.62 cM)5
    2576351  NM_133902.21  NP_598663.21 
     1204581865 
    chicken
    (Gallus gallus)
    Aves SDSL1 serine dehydratase-like 69.93(n)
    65.93(a)
      417030  NM_001198643.1  NP_001185572.1 
    lizard
    (Anolis carolinensis)
    Reptilia SDSL6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343338.1(897252-907224)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687902 hypothetical protein MGC68790 74.43(n)    BC060346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5636421 l-serine dehydratase/L-threonine deaminase-like 58.84(n)
    57.14(a)
      563642  XM_686998.4  XP_692090.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CHA1(YCL064C)4
    CHA11
    Catabolic L-serine (L-threonine) deaminase, catalyzes more4
    Cha1p1
    45.64(n)1
    38.93(a)1
      3(16880-15798)4
    8502951, 4  NP_001018030.11, 4 


    ENSEMBL Gene Tree for SDSL (if available)
    TreeFam Gene Tree for SDSL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SDSL gene
    SDS2  
    1 SIMAP similar gene for SDSL using alignment to 5 protein entries:     SDSL_HUMAN (see all proteins):
    SDS

    SDSL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/434 SNPs in SDSL are shown (see all 434)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11097911,2
    C,F,H--113858243(+) gcagcA/Gcagtg 1 -- us2k113Minor allele frequency- G:0.09NS EA NA CSA WA 774
    rs58009871,2
    C,F--113858266(+) ttGTaAAAC/-  
            
    aaaca
    1 -- us2k1 tfbs32Minor allele frequency- -:0.50NA CSA 4
    rs11097921,2
    C,F,H--113858310(+) GGTTAC/TGCTGG 1 -- us2k111Minor allele frequency- T:0.03NS EA NA WA 772
    rs1871927731,2
    --113858388(+) CTGAGA/CTGTGT 1 -- us2k10--------
    rs1904883251,2
    --113858390(+) GAGCTA/GTGTGC 1 -- us2k10--------
    rs1413380361,2
    --113858407(+) TCTGCC/TTACTT 1 -- us2k10--------
    rs1452779801,2
    --113858435(+) TCTTGC/TCCCAT 1 -- us2k10--------
    rs71323401,2
    C,F,A,H--113858486(+) TAGGAA/GGTGTT 1 -- us2k112Minor allele frequency- G:0.08NA EA CSA WA 730
    rs1830889171,2
    --113858602(+) GACAAA/GGCACC 1 -- us2k10--------
    rs1877950361,2
    --113858706(+) AAGTGA/GCTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SDSL (113860042 - 113876081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SDSL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519540CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SDSL
    DNA2.0 Custom Variant and Variant Library Synthesis for SDSL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SDSL:    About MalaCards
    schizoaffective disorder    

    1 disease from the University of Copenhagen DISEASES database for SDSL:
    Schizoaffective disorder

    SDSL for disorders           About GeneDecksing

    Genetic Association Database (GAD): SDSL
    Human Genome Epidemiology (HuGE) Navigator: SDSL (1 document)

    Export disorders for SDSL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SDSL gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SDSL)
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    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PubMed id 18342636)1, 2 Yamada T....Takusagawa F. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    8. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 113675 HGNC: 30404 AceView: SDSL Ensembl:ENSG00000139410 euGenes: HUgn113675
    ECgene: SDSL H-InvDB: SDSL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SDSL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SDSL gene:
    Search GeneIP for patents involving SDSL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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