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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SDSL Gene

protein-coding   GIFtS: 53
GCID: GC12P113860

serine dehydratase-like
  Search for SDSL
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SDSL    

Aliases
for SDSL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serine Dehydratase-Like1 2     L-Threonine Dehydratase2 3
SDS-RS11 2     SDH 22 3
Serine Dehydratase 22 3     SDH2
TDH2 3     Serine Dehydratase Related Sequence 12
L-Serine Deaminase2 3     EC 4.3.1.173
L-Serine Dehydratase/L-Threonine Deaminase2 3     EC 4.3.1.193

External Ids:    HGNC: 304041   Entrez Gene: 1136752   Ensembl: ENSG000001394107   UniProtKB: Q96GA73   

Export aliases for SDSL gene to outside databases

Previous GC identifers: GC12P112273 GC12P112322 GC12P110871


Summaries
for SDSL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7
Function: Has low serine dehydratase and threonine dehydratase activity




Genomic Views
for SDSL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SDSL gene promoter:
         TBP   MAZR   ATF-2   Tal-1beta   PPAR-alpha   PPAR-gamma1   c-Jun   PPAR-gamma2   ITF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SDSL promoter sequence
   Search SABiosciences Chromatin IP Primers for SDSL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDSL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.21

SDSL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDSL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113860:  view genomic region     (about GC identifiers)

Start:
 113,860,042 bp from pter      End:
 113,876,081 bp from pter
Size:
 16,040 bases      Orientation:
 plus strand

Proteins
for SDSL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7 (See protein sequence)
Recommended Name: Serine dehydratase-like  
Size: 329 amino acids; 34674 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer (Probable)
1 PDB 3D structure from and Proteopedia for SDSL:
2RKB (3D)    

Explore the universe of human proteins at neXtProt for SDSL: NX_Q96GA7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96GA7

    • SDSL Protein expression data from MOPED and PaxDb:    About this image 
    SDSL Protein Expression
    REFSEQ proteins: NP_612441.1  
    ENSEMBL proteins: 
     ENSP00000385790   ENSP00000448868   ENSP00000341117   ENSP00000446867   ENSP00000449136  
     ENSP00000448950  

    Human Recombinant Protein Products for SDSL: 
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    OriGene Protein Over-expression Lysate: SDSL
    OriGene Custom Protein Services for SDSL 
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    Novus Biologicals SDSL Proteins
    Novus Biologicals SDSL Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SDSL
    Uscn Proteins for SDSL

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--

    SDSL for ontologies           About GeneDecksing



    SDSL Antibody Products: 
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    Novus Biologicals SDSL Antibodies
    Abcam antibodies for SDSL 
    Uscn Antibodies for SDSL
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    Assay Products for SDSL: 
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    Uscn ELISAs and CLIAs for SDSL

    Protein Domains /
    Families
    for SDSL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SDSL for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF

    Graphical View of Domain Structure for InterPro Entry Q96GA7

    ProtoNet protein and cluster: Q96GA7

    2 Blocks protein families:
    IPB000634 Serine/threonine dehydratase
    IPB001926 Pyridoxal-5'-phosphate-dependent enzyme


    UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7
    Similarity: Belongs to the serine/threonine dehydratase family


    Function
    for SDSL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDSL_HUMAN, Q96GA7
    Function: Has low serine dehydratase and threonine dehydratase activity
    Catalytic activity: L-serine = pyruvate + NH(3)
    Catalytic activity: L-threonine = 2-oxobutanoate + NH(3)
    Biophysicochemical properties: Kinetic parameters: KM=30 mM for serine; KM=7 mM for threonine;

         Enzyme Numbers (IUBMB): EC 4.3.1.171 EC 4.3.1.191

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity ----
    GO:0003941L-serine ammonia-lyase activity IEA--
    GO:0004794L-threonine ammonia-lyase activity IEA--
    GO:0030170pyridoxal phosphate binding IEA--
         
    SDSL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SDSL 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SDSL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDSL
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SDSL
    SwitchGear 3'UTR luciferase reporter plasmid: SDSL 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDSL (see all 7)
    OriGene shRNA RFP: SDSL
    OriGene siRNA: SDSL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDSL
    Sirion Biotech Custom design and validation of potent shRNA sequences against SDSL 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SDSL
    Sirion Biotech Customized adenovirus for overexpression of SDSL 
    Sirion Biotech Customized adenovirus for potent knockdown of SDSL

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDSL (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDSL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SDSL (NM_138432)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDSL 

    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for SDSL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDSL


    Pathways & Interactions
    for SDSL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1glycine betaine degradation
    		glycine betaine degradation1.00
    2L-serine degradation
    		L-serine degradation1.00


    2 BioSystems Pathways for SDSL 
        glycine betaine degradation
    L-serine degradation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDSL

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for SDSL (Q96GA72, 3 ENSP000003411174) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TUBGCP4Q9UGJ12, 3, ENSP000002603834MINT-66914 I2D: score=4 STRING: ENSP00000260383
    SDSLQ96GA72MINT-66506
    SHMT1ENSP000003188684STRING: ENSP00000318868
    SHMT2ENSP000003336674STRING: ENSP00000333667
    SDAD1ENSP000003485964STRING: ENSP00000348596
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process IEA--
    GO:0008150biological_process ND--

    SDSL for ontologies           About GeneDecksing



    Drugs & Compounds
    for SDSL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SDSL

    1 HMDB Compound for SDSL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    1 DrugBank Compound for SDSL    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about SDSL 

    Transcripts
    for SDSL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SDSL gene: 
    NM_138432.2  

    Unigene Cluster for SDSL:

    Serine dehydratase-like
    Hs.337594  [show with all ESTs]
    Unigene Representative Sequence: BC009849
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403593(uc009zwh.3) ENST00000553248 ENST00000345635(uc001tvi.3)
    ENST00000547802 ENST00000546672 ENST00000551760

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SDSL
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDSL
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SDSL
    SwitchGear 3'UTR luciferase reporter plasmid: SDSL 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDSL (see all 7)
    OriGene shRNA RFP: SDSL
    OriGene siRNA: SDSL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDSL
    Sirion Biotech Custom design and validation of potent shRNA sequences against SDSL 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDSL (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDSL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SDSL (NM_138432)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDSL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDSL 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDSL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDSL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDSL

    Additional cDNA sequence: 

    AF134473.1 BC009849.2 BC091479.1 

    4 DOTS entries:

    DT.101977468  DT.100714735  DT.40204959  DT.121186756 

    24/64 AceView cDNA sequences (see all 64):

    BX092907 CB988193 BU902368 BE222929 BF064129 AI971693 BG679339 CA432646 
    CK819531 CB960840 BU543274 C16636 AI742027 BI670014 AI344703 BM129226 
    AI953998 BE273896 BQ930721 AI241423 BQ431764 BQ927418 BG473546 BM463961 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SDSL (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
    SP1:              -                                                                 -               
    SP2:              -     -                                                           -               
    SP3:              -     -     -     -                                                               
    SP4:                                            -                                   -               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SDSL

    Expression
    for SDSL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SDSL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACAGTCCTG
    SDSL Expression
    About this image

    SDSL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See SDSL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SDSL

    SOURCE GeneReport for Unigene cluster: Hs.337594
        SABiosciences Custom PCR Arrays for SDSL
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDSL

    Orthologs
    for SDSL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SDSL gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sdsl1 , 5 serine dehydratase-like1, 5 81.14(n)1
    81.04(a)1    		   5 (60.62 cM)5
    2576351  NM_133902.21  NP_598663.21 
     1204581865 
    chicken
    (Gallus gallus)    		 Aves SDSL1 serine dehydratase-like 69.93(n)
    65.93(a)    		   417030  NM_001198643.1  NP_001185572.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SDSL6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343338.1(898624-903092)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC687902 hypothetical protein MGC68790 74.43(n)    BC060346.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5636421 l-serine dehydratase/L-threonine deaminase-like 58.84(n)
    57.14(a)    		   563642  XM_686998.4  XP_692090.3 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CHA1(YCL064C)4
    CHA11    		 Catabolic L-serine (L-threonine) deaminase, catalyzes more4
    Cha1p1    		 45.64(n)1
    38.93(a)1    		   3(16880-15798)4
    8502951, 4  NP_001018030.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G728106
    MTO26
    		 threonine synthase 1
    		 10(a)
    10(a)
    		 possible ortholog
    possible ortholog
    		 1(27398591-27400417)
    4(14599216-14601055)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 threonine synthase, chloroplast precursor, putativ...
    threonine synthase, chloroplast precursor, putativ...
    		 11(a)
    10(a)
    		 possible ortholog
    possible ortholog
    		 1(28652918-28654903)
    5(27227914-27229941)


    ENSEMBL Gene Tree for SDSL (if available)
    TreeFam Gene Tree for SDSL (if available) 

    Paralogs
    for SDSL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SDSL gene
    ENSG000002576062  SDS2  
    1 SIMAP similar gene for SDSL using alignment to 5 protein entries:     SDSL_HUMAN (see all proteins):
    SDS

    SDSL for paralogs           About GeneDecksing



    Genomic Variants
    for SDSL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/354 NCBI SNPs in SDSL are shown (see all 354)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs11097911,2
    		C,F,H--113858243(+) GCAGCA/GCAGTG 1 -- us2k113Minor allele frequency- G:0.09NS EA NA CSA WA 774
    rs58009871,2
    		C,F--113858263(+) ttGTaAAAC/-  
                aaaca     		1 -- us2k1 tfbs32Minor allele frequency- -:0.50NA CSA 4
    rs11097921,2
    		C,F,H--113858310(+) GGTTAC/TGCTGG 1 -- us2k111Minor allele frequency- T:0.03NS EA NA WA 772
    rs1871927731,2
    		--113858388(+) CTGAGA/CTGTGT 1 -- us2k10--------
    rs1904883251,2
    		--113858390(+) GAGCTA/GTGTGC 1 -- us2k10--------
    rs1413380361,2
    		--113858407(+) TCTGCC/TTACTT 1 -- us2k10--------
    rs1452779801,2
    		--113858435(+) TCTTGC/TCCCAT 1 -- us2k10--------
    rs71323401,2
    		C,F,A,H--113858486(+) TAGGAA/GGTGTT 1 -- us2k112Minor allele frequency- G:0.08NA EA CSA WA 730
    rs1830889171,2
    		--113858602(+) GACAAA/GGCACC 1 -- us2k10--------
    rs1877950361,2
    		--113858706(+) AAGTGA/GCTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SDSL (113860042 - 113876081 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SDSL: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDSL
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    Disorders / Diseases
    for SDSL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SDSL for disorders           About MalaCards

    SDSL for disorders           About GeneDecksing

    1 disease from the University of Copenhagen DISEASES database for SDSL:
    Schizoaffective disorder
    Human Genome Epidemiology (HuGE) Navigator: SDSL (1 document)

    Export disorders for SDSL gene to outside databases

    Publications
    for SDSL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SDSL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SDSL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PubMed id 18342636)1, 2 Yamada T....Takusagawa F. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    6. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    7. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for SDSL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SDSL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113675 HGNC: 30404 AceView: SDSL Ensembl:ENSG00000139410 euGenes: HUgn113675
    ECgene: SDSL H-InvDB: SDSL

    Other Databases showing SDSL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SDSL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SDSL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SDSL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SDSL gene:
    Search GeneIP for patents involving SDSL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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