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Aliases for SDSL Gene

Aliases for SDSL Gene

  • Serine Dehydratase-Like 2 3
  • L-Serine Dehydratase/L-Threonine Deaminase 3 4
  • L-Threonine Dehydratase 3 4
  • Serine Dehydratase 2 3 4
  • L-Serine Deaminase 3 4
  • SDH 2 3 4
  • TDH 3 4
  • Serine Dehydratase Related Sequence 1 3
  • EC 4.3.1.19 4
  • EC 4.3.1.17 4
  • SDS-RS1 3
  • CSDH 3

External Ids for SDSL Gene

Summaries for SDSL Gene

GeneCards Summary for SDSL Gene

SDSL (Serine Dehydratase-Like) is a Protein Coding gene. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include pyridoxal phosphate binding and L-threonine ammonia-lyase activity. An important paralog of this gene is SDS.

UniProtKB/Swiss-Prot for SDSL Gene

  • Has low serine dehydratase and threonine dehydratase activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDSL Gene

Genomics for SDSL Gene

Genomic Location for SDSL Gene

Start:
113,422,237 bp from pter
End:
113,438,277 bp from pter
Size:
16,041 bases
Orientation:
Plus strand

Genomic View for SDSL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDSL Gene

Regulatory Elements for SDSL Gene

Proteins for SDSL Gene

  • Protein details for SDSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GA7-SDSL_HUMAN
    Recommended name:
    Serine dehydratase-like
    Protein Accession:
    Q96GA7
    Secondary Accessions:

    Protein attributes for SDSL Gene

    Size:
    329 amino acids
    Molecular mass:
    34674 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SDSL Gene

neXtProt entry for SDSL Gene

Proteomics data for SDSL Gene at MOPED

Post-translational modifications for SDSL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys227

Other Protein References for SDSL Gene

No data available for DME Specific Peptides for SDSL Gene

Domains for SDSL Gene

UniProtKB/Swiss-Prot:

SDSL_HUMAN
Family:
  • Belongs to the serine/threonine dehydratase family.:
    • Q96GA7
genes like me logo Genes that share domains with SDSL: view

No data available for Gene Families for SDSL Gene

Function for SDSL Gene

Molecular function for SDSL Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=30 mM for serine; KM=7 mM for threonine;
UniProtKB/Swiss-Prot CatalyticActivity: L-serine = pyruvate + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity: L-threonine = 2-oxobutanoate + NH(3).
UniProtKB/Swiss-Prot Function: Has low serine dehydratase and threonine dehydratase activity

Enzyme Numbers (IUBMB) for SDSL Gene

Gene Ontology (GO) - Molecular Function for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003941 L-serine ammonia-lyase activity IBA --
GO:0004794 L-threonine ammonia-lyase activity IBA --
GO:0030170 pyridoxal phosphate binding IBA --
genes like me logo Genes that share ontologies with SDSL: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SDSL Gene

Localization for SDSL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDSL Gene COMPARTMENTS Subcellular localization image for SDSL gene
Compartment Confidence
cytosol 3
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SDSL: view

Pathways for SDSL Gene

genes like me logo Genes that share pathways with SDSL: view

Gene Ontology (GO) - Biological Process for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process --
GO:0006565 L-serine catabolic process IBA --
GO:0006567 threonine catabolic process IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SDSL: view

Compounds for SDSL Gene

(1) HMDB Compounds for SDSL Gene

Compound Synonyms Cas Number PubMed IDs
Pyridoxal 5'-phosphate
  • Apolon B6
54-47-7

(1) Drugbank Compounds for SDSL Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor
genes like me logo Genes that share compounds with SDSL: view

Transcripts for SDSL Gene

Unigene Clusters for SDSL Gene

Serine dehydratase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDSL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:
SP6: -

Relevant External Links for SDSL Gene

GeneLoc Exon Structure for
SDSL
ECgene alternative splicing isoforms for
SDSL

Expression for SDSL Gene

mRNA expression in normal human tissues for SDSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDSL Gene

This gene is overexpressed in Liver (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDSL Gene

SOURCE GeneReport for Unigene cluster for SDSL Gene Hs.337594

genes like me logo Genes that share expressions with SDSL: view

Orthologs for SDSL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDSL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDSL 36
  • 99.19 (n)
  • 99.09 (a)
SDSL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SDSL 36
  • 84.65 (n)
  • 83.23 (a)
SDSL 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SDSL 36
  • 84.45 (n)
  • 83.54 (a)
SDSL 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdsl 36
  • 81.14 (n)
  • 81.04 (a)
Sdsl 16
Sdsl 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDSL 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDSL 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdsl 36
  • 81.19 (n)
  • 81.6 (a)
chicken
(Gallus gallus)
Aves SDSL 36
  • 69.93 (n)
  • 65.93 (a)
SDSL 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDSL 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68790 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sdsl 36
  • 63.85 (n)
  • 60.62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5154 36
zebrafish
(Danio rerio)
Actinopterygii LOC563642 36
  • 58.84 (n)
  • 57.14 (a)
SDSL 37
  • 54 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHA1 36
  • 44.3 (n)
  • 35.22 (a)
CHA1 37
  • 30 (a)
OneToMany
CHA1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00440g 36
  • 42.65 (n)
  • 35.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for SDSL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDSL Gene

ENSEMBL:
Gene Tree for SDSL (if available)
TreeFam:
Gene Tree for SDSL (if available)

Paralogs for SDSL Gene

Paralogs for SDSL Gene

Selected SIMAP similar genes for SDSL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SDSL: view

Variants for SDSL Gene

Sequence variations from dbSNP and Humsavar for SDSL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs734070 -- 113,421,646(+) GGAGA(A/G)GTGCT upstream-variant-2KB
rs875137 -- 113,421,255(-) caggg(A/T)agtat upstream-variant-2KB
rs1109791 -- 113,420,438(+) gcagc(A/G)cagtg upstream-variant-2KB
rs1109792 -- 113,420,505(+) GGTTA(C/T)GCTGG upstream-variant-2KB
rs1465542 -- 113,425,138(-) CCCAA(A/G)CAAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDSL Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV Gain+Loss 19592680

Relevant External Links for SDSL Gene

HapMap Linkage Disequilibrium report
SDSL

Disorders for SDSL Gene

(1) University of Copenhagen DISEASES for SDSL Gene

Relevant External Links for SDSL

Genetic Association Database (GAD)
SDSL
Human Genome Epidemiology (HuGE) Navigator
SDSL
genes like me logo Genes that share disorders with SDSL: view

No data available for UniProtKB/Swiss-Prot for SDSL Gene

Publications for SDSL Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Enzymatic and biochemical properties of a novel human serine dehydratase isoform. (PMID: 16580895) Ogawa H. … Kobayashi M. (Biochim. Biophys. Acta 2006) 2 3
  4. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PMID: 18342636) Yamada T. … Takusagawa F. (Biochim. Biophys. Acta 2008) 3 4
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3

Products for SDSL Gene

Sources for SDSL Gene

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