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SDSL Gene

protein-coding   GIFtS: 57
GCID: GC12P113860

Serine Dehydratase-Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine Dehydratase-Like1 2     SDH 22 3
Serine Dehydratase 22 3     SDH2
TDH2 3     SDS-RS12
L-Serine Deaminase2 3     Serine Dehydratase Related Sequence 12
L-Serine Dehydratase/L-Threonine Deaminase2 3     EC 4.3.1.173
L-Threonine Dehydratase2 3     EC 4.3.1.193

External Ids:    HGNC: 304041   Entrez Gene: 1136752   Ensembl: ENSG000001394107   UniProtKB: Q96GA73   

Export aliases for SDSL gene to outside databases

Previous GC identifers: GC12P112273 GC12P112322 GC12P110871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SDSL Gene:
SDSL (serine dehydratase-like) is a protein-coding gene. Diseases associated with SDSL include schizoaffective disorder. GO annotations related to this gene include pyridoxal phosphate binding and L-threonine ammonia-lyase activity. An important paralog of this gene is SDS.

UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7
Function: Has low serine dehydratase and threonine dehydratase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SDSL gene promoter:
         TBP   MAZR   ATF-2   Tal-1beta   PPAR-alpha   PPAR-gamma1   c-Jun   PPAR-gamma2   ITF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDSL promoter sequence
   Search Chromatin IP Primers for SDSL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDSL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.21

SDSL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDSL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113860:  view genomic region     (about GC identifiers)

Start:
113,860,042 bp from pter      End:
113,876,081 bp from pter
Size:
16,040 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7 (See protein sequence)
Recommended Name: Serine dehydratase-like  
Size: 329 amino acids; 34674 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer (Probable)
1 PDB 3D structure from and Proteopedia for SDSL:
2RKB (3D)    

Explore the universe of human proteins at neXtProt for SDSL: NX_Q96GA7

Explore proteomics data for SDSL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys227
  • Modification sites at PhosphoSitePlus

  • See SDSL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612441.1  
    ENSEMBL proteins: 
     ENSP00000385790   ENSP00000448868   ENSP00000341117   ENSP00000446867   ENSP00000449136  
     ENSP00000448950  

    SDSL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for SDSL
    OriGene Protein Over-expression Lysate for SDSL
    OriGene MassSpec for SDSL
    OriGene Custom Protein Services for SDSL
    GenScript Custom Purified and Recombinant Proteins Services for SDSL
    Novus Biologicals SDSL Proteins
    Novus Biologicals SDSL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SDSL
    Cloud-Clone Corp. Proteins for SDSL

    SDSL Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SDSL
    OriGene Custom Antibody Services for SDSL
    Novus Biologicals SDSL Antibodies
    Abcam antibodies for SDSL
    Cloud-Clone Corp. Antibodies for SDSL
    Search ThermoFisher Antibodies for SDSL
    LSBio Antibodies in human, mouse, rat for SDSL

    SDSL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SDSL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SDSL
    Cloud-Clone Corp. CLIAs for SDSL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF

    Graphical View of Domain Structure for InterPro Entry Q96GA7

    ProtoNet protein and cluster: Q96GA7

    2 Blocks protein domains:
    IPB000634 Serine/threonine dehydratase
    IPB001926 Pyridoxal-5'-phosphate-dependent enzyme


    UniProtKB/Swiss-Prot: SDSL_HUMAN, Q96GA7
    Similarity: Belongs to the serine/threonine dehydratase family


    SDSL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDSL_HUMAN, Q96GA7
    Function: Has low serine dehydratase and threonine dehydratase activity
    Catalytic activity: L-serine = pyruvate + NH(3)
    Catalytic activity: L-threonine = 2-oxobutanoate + NH(3)
    Biophysicochemical properties: Kinetic parameters: KM=30 mM for serine; KM=7 mM for threonine;

         Enzyme Numbers (IUBMB): EC 4.3.1.171 EC 4.3.1.191

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003941L-serine ammonia-lyase activity IEA--
    GO:0004794L-threonine ammonia-lyase activity IEA--
    GO:0030170pyridoxal phosphate binding IEA--
         
    SDSL for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Sdsl (no phenotypes)

    SDSL for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDSL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SDSL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SDSL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SDSL

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SDSL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SDSL
    SwitchGear 3'UTR luciferase reporter plasmidSDSL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SDSL
    Predesigned siRNA for gene silencing in human, mouse, rat SDSL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SDSL

    Clone
    Products:
         
    OriGene clones in human, mouse for SDSL (see all 7)
    OriGene ORF clones in mouse, rat for SDSL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SDSL (NM_138432)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDSL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDSL

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SDSL
    Browse ESI BIO Cell Lines and PureStem Progenitors for SDSL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDSL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--

    SDSL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SDSL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Carbon metabolism
    Biosynthesis of amino acids0.38
    Valine, leucine and isoleucine biosynthesis0.00
    Carbon metabolism0.38
    L-serine degradation0.00
    2Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism
    glycine betaine degradation0.00
    3Metabolism
    Metabolic pathways0.38
    4Sulfur amino acid metabolism
    Cysteine and methionine metabolism0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SDSL
        glycine betaine degradation
    L-serine degradation


    Selected Kegg Pathways  (Kegg details for SDSL) (see all 6):
        Glycine, serine and threonine metabolism
    Cysteine and methionine metabolism
    Valine, leucine and isoleucine biosynthesis
    Metabolic pathways
    Carbon metabolism


    SDSL for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SDSL
    Interactions:

        Search GeneGlobe Interaction Network for SDSL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SDSL (Q96GA72, 3 ENSP000003411174) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TUBGCP4Q9UGJ12, 3, ENSP000002603834MINT-66914 I2D: score=4 STRING: ENSP00000260383
    SDSLQ96GA72MINT-66506
    SHMT1ENSP000003188684STRING: ENSP00000318868
    SHMT2ENSP000003336674STRING: ENSP00000333667
    EEF2ENSP000003079404STRING: ENSP00000307940
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process IEA--
    GO:0008150biological_process ND--

    SDSL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SDSL

    1 HMDB Compound for SDSL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    1 DrugBank Compound for SDSL    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SDSL gene: 
    NM_138432.2  

    Unigene Cluster for SDSL:

    Serine dehydratase-like
    Hs.337594  [show with all ESTs]
    Unigene Representative Sequence: BC009849
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403593(uc009zwh.3) ENST00000553248 ENST00000345635(uc001tvi.3)
    ENST00000547802 ENST00000546672 ENST00000551760
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SDSL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SDSL
    SwitchGear 3'UTR luciferase reporter plasmidSDSL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SDSL
    Predesigned siRNA for gene silencing in human, mouse, rat SDSL
    Clone
    Products:
         
    OriGene clones in human, mouse for SDSL (see all 7)
    OriGene ORF clones in mouse, rat for SDSL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SDSL (NM_138432)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDSL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDSL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SDSL
    OriGene qSTAR qPCR primer pairs in human, mouse for SDSL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SDSL
      QuantiTect SYBR Green Assays in human, mouse, rat SDSL
      QuantiFast Probe-based Assays in human, mouse, rat SDSL

    Additional mRNA sequence: 

    AF134473.1 BC009849.2 BC091479.1 

    4 DOTS entries:

    DT.101977468  DT.100714735  DT.40204959  DT.121186756 

    Selected AceView cDNA sequences (see all 64):

    CK819531 CB988193 C16636 CB960840 BU543274 BX092907 BU902368 BG679339 
    AI971693 BF064129 CA432646 BE222929 BU542644 BE273896 BQ279051 BG912245 
    AI524349 BQ951062 BG774012 BC009849 NM_138432 BU540522 BM463961 BQ434406 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SDSL (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
    SP1:              -                                                                 -               
    SP2:              -     -                                                           -               
    SP3:              -     -     -     -                                                               
    SP4:                                            -                                   -               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SDSL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SDSL expression in normal human tissues (normalized intensities)      SDSL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGTCCTG
    SDSL Expression
    About this image


    SDSL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    SDSL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SDSL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.337594
        Custom PCR Arrays for SDSL
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SDSL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDSL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SDSL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdsl1 , 5 serine dehydratase-like1, 5 81.14(n)1
    81.04(a)1
      5 (60.62 cM)5
    2576351  NM_133902.21  NP_598663.21 
     1204581865 
    chicken
    (Gallus gallus)
    Aves SDSL1 serine dehydratase-like 69.93(n)
    65.93(a)
      417030  NM_001198643.1  NP_001185572.1 
    lizard
    (Anolis carolinensis)
    Reptilia SDSL6
    serine dehydratase-like
    64(a)
    1 ↔ 1
    GL343338.1(897252-907224)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687902 hypothetical protein MGC68790 74.43(n)    BC060346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5636421 serine dehydratase-like 58.84(n)
    57.14(a)
      563642  XM_005169843.1  XP_005169900.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CHA1(YCL064C)4
    CHA11
    Catabolic L-serine (L-threonine) deaminase, catalyzes more4
    CHA11
    44.3(n)1
    35.22(a)1
      3(16880-15798)4
    8502951, 4  NP_001018030.11, 4 


    ENSEMBL Gene Tree for SDSL (if available)
    TreeFam Gene Tree for SDSL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SDSL gene
    SDS2  
    1 SIMAP similar gene for SDSL using alignment to 5 protein entries:     SDSL_HUMAN (see all proteins):
    SDS

    SDSL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SDSL (see all 434)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11097911,2
    C,F,H--113858243(+) gcagcA/Gcagtg 1 -- us2k113Minor allele frequency- G:0.09NS EA NA CSA WA 774
    rs58009871,2
    C,F--113858266(+) ttGTaAAAC/-  
            
    aaaca
    1 -- us2k1 tfbs32Minor allele frequency- -:0.50NA CSA 4
    rs11097921,2
    C,F,H--113858310(+) GGTTAC/TGCTGG 1 -- us2k111Minor allele frequency- T:0.03NS EA NA WA 772
    rs1871927731,2
    --113858388(+) CTGAGA/CTGTGT 1 -- us2k10--------
    rs1904883251,2
    --113858390(+) GAGCTA/GTGTGC 1 -- us2k10--------
    rs1413380361,2
    --113858407(+) TCTGCC/TTACTT 1 -- us2k10--------
    rs1452779801,2
    --113858435(+) TCTTGC/TCCCAT 1 -- us2k10--------
    rs71323401,2
    C,F,A,H--113858486(+) TAGGAA/GGTGTT 1 -- us2k112Minor allele frequency- G:0.08NA EA CSA WA 730
    rs1830889171,2
    --113858602(+) GACAAA/GGCACC 1 -- us2k10--------
    rs1877950361,2
    --113858706(+) AAGTGA/GCTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SDSL (113860042 - 113876081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SDSL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519540CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SDSL
    DNA2.0 Custom Variant and Variant Library Synthesis for SDSL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SDSL:    About MalaCards
    schizoaffective disorder

    1 disease from the University of Copenhagen DISEASES database for SDSL:
    Schizoaffective disorder

    SDSL for disorders           About GeneDecksing

    Genetic Association Database (GAD): SDSL
    Human Genome Epidemiology (HuGE) Navigator: SDSL (1 document)

    Export disorders for SDSL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SDSL gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SDSL)
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    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PubMed id 18342636)1, 2 Yamada T....Takusagawa F. (Biochim. Biophys. Acta 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    9. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 113675 HGNC: 30404 AceView: SDSL Ensembl:ENSG00000139410 euGenes: HUgn113675
    ECgene: SDSL Kegg: 113675 H-InvDB: SDSL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SDSL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SDSL gene:
    Search GeneIP for patents involving SDSL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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