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Aliases for SDSL Gene

Aliases for SDSL Gene

  • Serine Dehydratase Like 2 3 5
  • L-Serine Dehydratase/L-Threonine Deaminase 3 4
  • L-Threonine Dehydratase 3 4
  • Serine Dehydratase-Like 2 3
  • Serine Dehydratase 2 3 4
  • L-Serine Deaminase 3 4
  • SDH 2 3 4
  • TDH 3 4
  • Serine Dehydratase Related Sequence 1 3
  • EC 4
  • EC 4
  • SDS-RS1 3
  • CSDH 3

External Ids for SDSL Gene

Previous GeneCards Identifiers for SDSL Gene

  • GC12P112273
  • GC12P112322
  • GC12P113860
  • GC12P110871

Summaries for SDSL Gene

GeneCards Summary for SDSL Gene

SDSL (Serine Dehydratase Like) is a Protein Coding gene. Diseases associated with SDSL include Subdural Empyema and Brain Compression. Among its related pathways are threonine degradation and Carbon metabolism. GO annotations related to this gene include pyridoxal phosphate binding and L-threonine ammonia-lyase activity. An important paralog of this gene is SDS.

UniProtKB/Swiss-Prot for SDSL Gene

  • Has low serine dehydratase and threonine dehydratase activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDSL Gene

Genomics for SDSL Gene

Regulatory Elements for SDSL Gene

Enhancers for SDSL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G113417 1.5 FANTOM5 Ensembl ENCODE 31.3 -3.8 -3825 1.0 ELF3 PKNOX1 ARID4B DNMT3B RAD21 RARA YY1 THAP11 SP5 MXD4 SDSL PLBD2 SLC8B1 SDS OAS2 OAS3 LOC105369989
GH12G113270 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.2 -150.2 -150199 2.3 ELF3 ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 EGR1 EGR2 USF2 CEBPB SDSL RASAL1 RITA1 SLC8B1 OAS2 OAS3 OAS1 PLBD2 SDS GC12M113256
GH12G113141 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.8 -279.7 -279731 2.1 ZMYM3 MNT REST ATF2 ZNF121 KDM1A HNRNPL TRIM28 SDSL RASAL1 SLC8B1 CFAP73 OAS2 OAS3 OAS1 SDS
GH12G113356 1.4 FANTOM5 ENCODE 20.8 -63.6 -63632 4.0 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 PLBD2 DDX54 SDSL RBM19 RITA1 ENSG00000201208 SLC8B1 SDS
GH12G113415 1.2 Ensembl ENCODE 20.2 -6.0 -5954 1.2 PKNOX1 ATF1 TCF12 ZNF766 KDM4B MEF2D SREBF1 MAFF ZNF610 SMARCA4 SDSL LOC105369989
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDSL on UCSC Golden Path with GeneCards custom track

Promoters for SDSL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057635 263 1001 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF766 FOS ZNF263 SP3 JUNB

Genomic Location for SDSL Gene

113,422,237 bp from pter
113,438,277 bp from pter
16,041 bases
Plus strand

Genomic View for SDSL Gene

Genes around SDSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDSL Gene

Proteins for SDSL Gene

  • Protein details for SDSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine dehydratase-like
    Protein Accession:

    Protein attributes for SDSL Gene

    329 amino acids
    Molecular mass:
    34674 Da
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SDSL Gene

neXtProt entry for SDSL Gene

Post-translational modifications for SDSL Gene

  • Ubiquitination at isoforms=227
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SDSL Gene

Domains & Families for SDSL Gene

Suggested Antigen Peptide Sequences for SDSL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serine/threonine dehydratase family.
  • Belongs to the serine/threonine dehydratase family.
genes like me logo Genes that share domains with SDSL: view

No data available for Gene Families for SDSL Gene

Function for SDSL Gene

Molecular function for SDSL Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 mM for serine; KM=7 mM for threonine;
UniProtKB/Swiss-Prot CatalyticActivity:
L-serine = pyruvate + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
L-threonine = 2-oxobutanoate + NH(3).
UniProtKB/Swiss-Prot Function:
Has low serine dehydratase and threonine dehydratase activity.

Enzyme Numbers (IUBMB) for SDSL Gene

Gene Ontology (GO) - Molecular Function for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003941 L-serine ammonia-lyase activity IEA --
GO:0004794 L-threonine ammonia-lyase activity IEA --
GO:0016829 lyase activity IEA --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with SDSL: view
genes like me logo Genes that share phenotypes with SDSL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SDSL

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SDSL Gene

Localization for SDSL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDSL gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 2
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SDSL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SDSL Gene

Pathways & Interactions for SDSL Gene

genes like me logo Genes that share pathways with SDSL: view

Gene Ontology (GO) - Biological Process for SDSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SDSL: view

No data available for SIGNOR curated interactions for SDSL Gene

Drugs & Compounds for SDSL Gene

(5) Drugs for SDSL Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist Weak endogenous glycine receptor agonist 0
L-Threonine Approved Nutra 0
Pyruvic acid Approved Nutra 0
2-Ketobutyric acid Experimental Pharma 0
Pyridoxal Phosphate Nutra Target, cofactor 15

(1) Additional Compounds for SDSL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
genes like me logo Genes that share compounds with SDSL: view

Transcripts for SDSL Gene

Unigene Clusters for SDSL Gene

Serine dehydratase-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SDSL

Alternative Splicing Database (ASD) splice patterns (SP) for SDSL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP6: -

Relevant External Links for SDSL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDSL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDSL Gene

This gene is overexpressed in Liver (x11.6).

Protein differential expression in normal tissues from HIPED for SDSL Gene

This gene is overexpressed in Liver (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDSL Gene

Protein tissue co-expression partners for SDSL Gene

NURSA nuclear receptor signaling pathways regulating expression of SDSL Gene:


SOURCE GeneReport for Unigene cluster for SDSL Gene:


Evidence on tissue expression from TISSUES for SDSL Gene

  • Liver(4.2)
  • Lung(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with SDSL: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDSL Gene

Orthologs for SDSL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDSL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SDSL 34 35
  • 99.19 (n)
(Bos Taurus)
Mammalia SDSL 34 35
  • 84.65 (n)
(Canis familiaris)
Mammalia SDSL 34 35
  • 84.45 (n)
(Rattus norvegicus)
Mammalia Sdsl 34
  • 81.19 (n)
(Mus musculus)
Mammalia Sdsl 34 16 35
  • 81.14 (n)
(Monodelphis domestica)
Mammalia SDSL 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SDSL 35
  • 61 (a)
(Gallus gallus)
Aves SDSL 34 35
  • 69.93 (n)
(Anolis carolinensis)
Reptilia SDSL 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sdsl 34
  • 63.85 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68790 34
(Danio rerio)
Actinopterygii LOC563642 34
  • 58.84 (n)
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5154 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHA1 34 35 37
  • 44.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00440g 34
  • 42.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
Species where no ortholog for SDSL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDSL Gene

Gene Tree for SDSL (if available)
Gene Tree for SDSL (if available)

Paralogs for SDSL Gene

Paralogs for SDSL Gene

(1) SIMAP similar genes for SDSL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SDSL: view

Variants for SDSL Gene

Sequence variations from dbSNP and Humsavar for SDSL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000047804 -- 113,434,078(+) GCTCC(A/G)GCCTC intron-variant
rs1000071921 -- 113,431,862(+) GCCTC(C/G)CGAGT intron-variant
rs1000078800 -- 113,433,795(+) AGGGG(A/G)CTTCT intron-variant
rs1000181880 -- 113,427,391(+) CAGGC(A/G)TGAGC intron-variant
rs1000383268 -- 113,421,789(+) GAGTT(C/T)GAGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDSL Gene

Variant ID Type Subtype PubMed ID
esv3630792 CNV gain 21293372
esv3892265 CNV gain 25118596
nsv1118505 CNV duplication 24896259
nsv519540 CNV gain+loss 19592680

Variation tolerance for SDSL Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDSL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDSL Gene

Disorders for SDSL Gene

MalaCards: The human disease database

(3) MalaCards diseases for SDSL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
subdural empyema
  • subdural abscess
brain compression
  • compression of brain
vertebral artery occlusion
  • occlusion and stenosis of vertebral artery
- elite association - COSMIC cancer census association via MalaCards
Search SDSL in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDSL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SDSL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDSL Gene

Publications for SDSL Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PMID: 18342636) Yamada T. … Takusagawa F. (Biochim. Biophys. Acta 2008) 3 4 64
  3. Enzymatic and biochemical properties of a novel human serine dehydratase isoform. (PMID: 16580895) Ogawa H. … Kobayashi M. (Biochim. Biophys. Acta 2006) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SDSL Gene

Sources for SDSL Gene

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