Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SDS Gene

protein-coding   GIFtS: 59
GCID: GC12M113830

serine dehydratase
 Explore 3 diseases affiliated with
SDS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SDS    

Aliases
for SDS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serine Dehydratase1 2     L-Serine Ammonia-Lyase2
SDH1 2 3     L-Serine Dehydratase2
TDH2 3     L-Serine Dehydratase/L-Threonine Deaminase2
L-Serine Deaminase2 3     EC 4.3.1.173
L-Threonine Dehydratase2 3     EC 4.3.1.193

External Ids:    HGNC: 106911   Entrez Gene: 109932   Ensembl: ENSG000001350947   OMIM: 1821285   UniProtKB: P201323   

Export aliases for SDS gene to outside databases

Previous GC identifers: GC12M112739 GC12M113349 GC12M113613 GC12M112242 GC12M112292 GC12M110841


Summaries
for SDS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SDS:
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase
converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also
metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. (provided by
RefSeq, Jul 2008)




Genomic Views
for SDS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SDS gene promoter:
         TBP   Spz1   AP-2alpha isoform 3   AP-1   ATF-2   AP-2alpha isoform 2   c-Jun   AP-2alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SDS promoter sequence
   Search SABiosciences Chromatin IP Primers for SDS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.13

SDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M113830:  view genomic region     (about GC identifiers)

Start:
 113,830,250 bp from pter      End:
 113,841,693 bp from pter
Size:
 11,444 bases      Orientation:
 minus strand

Proteins
for SDS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SDHL_HUMAN, P20132 (See protein sequence)
Recommended Name: L-serine dehydratase/L-threonine deaminase  
Size: 328 amino acids; 34625 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for SDS:
1P5J (3D)        4H27 (3D)    
Secondary accessions: A8K9P5

Explore the universe of human proteins at neXtProt for SDS: NX_P20132

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P20132

    • SDS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006834.2  
    ENSEMBL proteins: 
     ENSP00000257549   ENSP00000449833  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SDS
    OriGene Protein Over-expression Lysate: SDS
    OriGene Custom Protein Services for SDS 
    GenScript Custom Purified and Recombinant Proteins Services for SDS
    Novus Biologicals SDS Protein
    Novus Biologicals SDS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SDS

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ----
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--


    SDS for ontologies           About GeneDecksing



    SDS Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 9): SDS
    OriGene Custom Antibody Services for SDS 
    GenScript Superior Antibodies for SDS
    Novus Biologicals SDS Antibodies
    Search for Antibodies for SDS at Abcam  
    Uscn Antibodies for SDS
    ThermoFisher Antibodies for SDS

    Assay Products for SDS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SDS
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SDS

    Protein Domains /
    Families
    for SDS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SDS for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF

    Graphical View of Domain Structure for InterPro Entry P20132

    ProtoNet protein and cluster: P20132

    2 Blocks protein families:
    IPB000634 Serine/threonine dehydratase
    IPB001926 Pyridoxal-5'-phosphate-dependent enzyme


    UniProtKB/Swiss-Prot: SDHL_HUMAN, P20132
    Similarity: Belongs to the serine/threonine dehydratase family


    Function
    for SDS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SDHL_HUMAN, P20132
    Catalytic activity: L-serine = pyruvate + NH(3)
    Catalytic activity: L-threonine = 2-oxobutanoate + NH(3)
    Biophysicochemical properties: Kinetic parameters: KM=23 mM for serine; KM=31 mM for threonine;

         Genatlas biochemistry entry for SDS:
    serine dehydratase,liver,murine ortholog

    Enzyme Numbers (IUBMB): EC 4.3.1.171 EC 4.3.1.191

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SDS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDS
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SDS:
    hsa-miR-508-5p hsa-miR-1261
    SwitchGear 3'UTR luciferase reporter plasmid: SDS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDS (see all 7)
    OriGene shRNA RFP: SDS
    OriGene siRNA: SDS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SDS

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SDS (NM_006843)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDS 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SDS
    Search LifeMap BioReagents cell lines for SDS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDS

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0003941L-serine ammonia-lyase activity IDA15689518
    GO:0004794L-threonine ammonia-lyase activity IEA--
    GO:0030170pyridoxal phosphate binding IDA15689518
    GO:0042803protein homodimerization activity IDA15689518


    SDS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SDS:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for SDS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1L-serine degradation
    		L-serine degradation1.00
    2glycine betaine degradation
    		glycine betaine degradation1.00
    3Glycine, serine and threonine metabolism
    		Glycine, serine and threonine metabolism1.00
    4Metabolism
    		Metabolic pathways0.38
    5Sulfur amino acid metabolism
    		Cysteine and methionine metabolism0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for SDS 
        glycine betaine degradation
    L-serine degradation


    3         Kegg Pathways  (Kegg details for SDS):
        Glycine, serine and threonine metabolism
    Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SDHL_HUMAN, P20132
    Pathway: Carbohydrate biosynthesis; gluconeogenesis


    SDS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/32 Interacting proteins for SDS (P201323 ENSP000002575494) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006094gluconeogenesis IEA--
    GO:0006520cellular amino acid metabolic process ----
    GO:0006565L-serine catabolic process IDA15689518
    GO:0033590response to cobalamin IEA--
    GO:0042866pyruvate biosynthetic process IDA15689518


    SDS for ontologies           About GeneDecksing



    Drugs & Compounds
    for SDS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SDS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SDS

    6 HMDB Compounds for SDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Aminoacrylic acidDehydroalanine (see all 6)----
    AmmoniaNH3 (see all 31)7664-41-7--
    L-Serine(-)-Serine (see all 26)56-45-1--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for SDS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Serine(-)-Serine (see all 11)56-45-1target--14688104 17139284 4377655 500557 17016423
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor14596599 15155761 15689518 16580895 14646100

    6 Novoseek chemical compound relationships for SDS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetoacetate 70.6 5 15689518 (1), 18342636 (1)
    pyridoxal 5-phosphate 68.3 12 16580895 (1), 14646100 (1), 18342636 (1)
    serine 68.2 50 14646100 (3), 15618015 (3), 19887726 (2), 15689518 (2) (see all 17)
    pyruvate 64.7 14 19887726 (1), 17949340 (1), 14646100 (1), 15689518 (1) (see all 7)
    phosphoenolpyruvate 48.5 1 9239284 (1)
    threonine 45 4 16580895 (1), 15689518 (1), 8452219 (1)

    Search CenterWatch for drugs/clinical trials and news about SDS / SDHL 

    Transcripts
    for SDS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SDS gene: 
    NM_006843.2  

    Unigene Cluster for SDS:

    Serine dehydratase
    Hs.439023  [show with all ESTs]
    Unigene Representative Sequence: AK124290
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257549(uc001tvg.3) ENST00000553112(uc001tvh.1) ENST00000552280
    ENST00000546639 ENST00000546785

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SDS
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDS
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SDS:
    hsa-miR-508-5p hsa-miR-1261
    SwitchGear 3'UTR luciferase reporter plasmid: SDS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDS (see all 7)
    OriGene shRNA RFP: SDS
    OriGene siRNA: SDS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDS
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SDS (NM_006843)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDS 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDS
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDS

    Additional cDNA sequence: 

    AK124290.1 AK292760.1 BC020750.1 J05037.1 

    5 DOTS entries:

    DT.95156558  DT.97838379  DT.99927232  DT.91981767  DT.121186761 

    24/109 AceView cDNA sequences (see all 109):

    F04480 CD623369 NM_006843 CB163864 AW206387 CB133212 CB161430 BG566257 
    CR609930 CA307012 BM856186 CB138228 BQ184190 AA427533 BM727512 BM805738 
    T28649 AK124290 BX104228 BM684964 CB155931 BU740747 BM931914 BX645273 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SDS    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                    -           -                                       
    SP2:                    -           -                                       
    SP3:                    -                                                   
    SP4:                    -     -     -     -     -                           
    SP5:                                                                        


    ECgene alternative splicing isoforms for SDS

    Expression
    for SDS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SDS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGAAACCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SDS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SDS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SDS

    SOURCE GeneReport for Unigene cluster: Hs.439023
        SABiosciences Expression via Pathway-Focused PCR Arrays including SDS: 
              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDS
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDS
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDS
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDS

    Orthologs
    for SDS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SDS gene from 5/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SDS6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343338.1(886298-890277)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.16692 Xenopus laevis cDNA clone IMAGE6880181 72.55(n)    BC058326.1 
    A. gossypii yeast
    (Ashbya gossypii)    		 Saccharomycetes AGOS_AFR747W1 AFR747Wp 48.07(n)
    42.86(a)    		   4622587  NM_212432.1  NP_986296.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MTO26
    AT1G728106
    		 threonine synthase 2
    		 9(a)
    9(a)
    		 possible ortholog
    possible ortholog
    		 4(14599216-14601055)
    1(27398591-27400417)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 threonine synthase, chloroplast precursor, putativ...
    threonine synthase, chloroplast precursor, putativ...
    		 9(a)
    10(a)
    		 possible ortholog
    possible ortholog
    		 1(28652918-28654903)
    5(27227914-27229941)


    ENSEMBL Gene Tree for SDS (if available)
    TreeFam Gene Tree for SDS (if available) 

    Paralogs
    for SDS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SDS gene
    SDSL2  ENSG000002576062  
    1 SIMAP similar gene for SDS using alignment to 3 protein entries:     SDHL_HUMAN (see all proteins):
    SDSL

    SDS for paralogs           About GeneDecksing



    Genomic Variants
    for SDS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 NCBI SNPs in SDS are shown (see all 302)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1893492661,2
    		--113829787(+) TGATAC/TGGGCT 1 -- ds50010--------
    rs340992851,2
    		C,F,--113829927(+) GGGAGG/CGGGCC 1 -- ds50014Minor allele frequency- C:0.07NA EA 248
    rs1384438881,2
    		--113830035(+) CCTTCA/TGCGGA 1 -- ds50010--------
    rs1820075261,2
    		--113830164(+) GGCCCC/TAGTTG 1 -- ds50010--------
    rs575702451,2
    		C,--113830266(+) AATATG/ATTTTA 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1837227021,2
    		--113830329(+) GGCTTC/GCTGGG 1 -- ut310--------
    rs1884332661,2
    		--113830338(+) GGAGGA/GTGGCT 1 -- ut310--------
    rs1461540981,2
    		--113830364(+) CCCTGA/GTTGGT 1 -- ut310--------
    rs1813087391,2
    		--113830384(+) GACCTG/TCACTG 1 -- ut310--------
    rs1162775941,2
    		C,F,--113830444(+) GTGATT/GCAGGT 1 -- ut311Minor allele frequency- G:0.09WA 118

    HapMap Linkage Disequilibrium report for SDS (113830250 - 113841693 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SDS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDS
    DNA2.0 Custom Variant and Variant Library Synthesis for SDS

    Disorders / Diseases
    for SDS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SDS for disorders           About GeneDecksing

    OMIM gene information: 182128    OMIM disorders: --

    3 diseases for SDS:    About MalaCards
    hypervitaminosis a    neuromuscular disease    diabetic retinopathy

    1 disease from the University of Copenhagen DISEASES database for SDS:
    Hypervitaminosis A
    Human Genome Epidemiology (HuGE) Navigator: SDS (104 documents)

    Export disorders for SDS gene to outside databases

    Publications
    for SDS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SDS gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with SDS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystallization and preliminary crystallographic analysis of human serine dehydratase. (PubMed id 14646100)1, 2, 7, 9 Sun L....Rao Z. (2003)
    2. Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources. (PubMed id 2674117)1, 2, 3 Ogawa H.... Fujioka M. (1989)
    3. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PubMed id 18342636)1, 2, 9 Yamada T....Takusagawa F. (2008)
    4. Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver. (PubMed id 15689518)1, 7, 9 Sun L....Rao Z. (2005)
    5. Enzymatic and biochemical properties of a novel human serine dehydratase isoform. (PubMed id 16580895)7, 9 Ogawa H....Kobayashi M. (2006)
    6. Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase. (PubMed id 10347152)1, 9 Xue H.H....Ichiyama A. (1999)
    7. Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy. (PubMed id 18289528)1 Szaflik J.P....Blasiak J. (2008)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    10. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)

    External Searches for SDS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SDS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10993 HGNC: 10691 AceView: SDS Ensembl:ENSG00000135094 euGenes: HUgn10993
    ECgene: SDS Kegg: 10993 H-InvDB: SDS

    Other Databases showing SDS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SDS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SDS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SDS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SDS gene:
    Search GeneIP for patents involving SDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SDS gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SDS   OriGene shRNA RFP for SDS  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDS   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDS  
     OriGene Protein Over-expression Lysate for SDS   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SDS   OriGene 3'-UTR Clone for SDS  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDS   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDS  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SDS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SDS   OriGene Custom Protein Services for SDS  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDS
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDS
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDS
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDS
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDS
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDS
     GenScript Custom Purified and Recombinant Proteins Services for SDS GenScript cDNA clones with any tag delivered in your preferred vector for SDS
     GenScript Custom Assay Services for SDS GenScript Superior Antibodies for SDS
     GenScript Custom overexpressing Cell Line Services for SDS CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SDS promoter
     Search Chromatin IP Primers for SDS
     RT2 qPCR Primer Assay in human, mouse, rat SDS
     Search GNC Networks for SDS
     SABiosciences PCR Arrays including human, mouse, rat SDS
     Search Tocris compounds for SDS
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SDS antibodies
     SDS proteins
     SDS lysates
     Search for Antibodies for SDS at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SDS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SDS Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SDS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDS
     SwitchGear 3'UTR luciferase reporter plasmids for SDS
     SwitchGear Promoter luciferase reporter plasmids for SDS
     ThermoFisher Antibodies for SDS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDS
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SDS gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4