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Aliases for SDS Gene

Aliases for SDS Gene

  • Serine Dehydratase 2 3 5
  • L-Threonine Dehydratase 3 4
  • L-Serine Ammonia-Lyase 2 3
  • L-Serine Deaminase 3 4
  • SDH 3 4
  • TDH 3 4
  • L-Serine Dehydratase/L-Threonine Deaminase 3
  • L-Serine Dehydratase 3
  • EC 4
  • EC 4

External Ids for SDS Gene

Previous GeneCards Identifiers for SDS Gene

  • GC12M112739
  • GC12M113349
  • GC12M113613
  • GC12M112242
  • GC12M112292
  • GC12M113830
  • GC12M110841

Summaries for SDS Gene

Entrez Gene Summary for SDS Gene

  • This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDS Gene

SDS (Serine Dehydratase) is a Protein Coding gene. Diseases associated with SDS include Autosomal Dominant Nonsyndromic Deafness 69. Among its related pathways are Metabolism and threonine degradation. GO annotations related to this gene include protein homodimerization activity and L-serine ammonia-lyase activity. An important paralog of this gene is SDSL.

Additional gene information for SDS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDS Gene

Genomics for SDS Gene

Regulatory Elements for SDS Gene

Enhancers for SDS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H113417 1.5 FANTOM5 Ensembl ENCODE 1.9 +7.9 7889 1 ELF3 FOXA2 ARID4B DNMT3B RAD21 RARA YY1 RCOR1 ATF7 THAP11 SDSL PLBD2 SLC8B1 SDS OAS2 OAS3 LOC105369989
GH12H113141 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +283.8 283795 2.1 ZNF121 POLR2A ZMYM3 MNT SDSL RASAL1 SLC8B1 CFAP73 OAS2 OAS3 OAS1 SDS
GH12H113356 1.3 FANTOM5 ENCODE 1.4 +67.7 67696 4 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 SP3 RBM19 PLBD2 DDX54 SDSL RITA1 ENSG00000201208 RPL6 SLC8B1 SDS
GH12H113425 1.1 Ensembl ENCODE 0.7 +0.5 491 1.3 HDGF PTBP1 RB1 NFXL1 BATF RAD21 EGR1 ZNF143 RUNX3 IKZF2 SDSL SDS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDS on UCSC Golden Path with GeneCards custom track

Genomic Locations for SDS Gene

Genomic Locations for SDS Gene
33,857 bases
Minus strand

Genomic View for SDS Gene

Genes around SDS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDS Gene

Proteins for SDS Gene

  • Protein details for SDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    L-serine dehydratase/L-threonine deaminase
    Protein Accession:
    Secondary Accessions:
    • A8K9P5

    Protein attributes for SDS Gene

    328 amino acids
    Molecular mass:
    34625 Da
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SDS Gene

neXtProt entry for SDS Gene

Post-translational modifications for SDS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDS Gene

Domains & Families for SDS Gene

Gene Families for SDS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SDS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serine/threonine dehydratase family.
  • Belongs to the serine/threonine dehydratase family.
genes like me logo Genes that share domains with SDS: view

Function for SDS Gene

Molecular function for SDS Gene

GENATLAS Biochemistry:
serine dehydratase,liver,murine ortholog
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=23 mM for serine {ECO:0000269 PubMed:18342636}; KM=31 mM for threonine {ECO:0000269 PubMed:18342636};
UniProtKB/Swiss-Prot CatalyticActivity:
L-serine = pyruvate + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
L-threonine = 2-oxobutanoate + NH(3).

Enzyme Numbers (IUBMB) for SDS Gene

Phenotypes From GWAS Catalog for SDS Gene

Gene Ontology (GO) - Molecular Function for SDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003941 L-serine ammonia-lyase activity IDA 15689518
GO:0004794 L-threonine ammonia-lyase activity IEA --
GO:0016829 lyase activity IEA --
GO:0030170 pyridoxal phosphate binding IDA,IEA 15689518
GO:0042803 protein homodimerization activity IDA 15689518
genes like me logo Genes that share ontologies with SDS: view
genes like me logo Genes that share phenotypes with SDS: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SDS Gene

Localization for SDS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDS gene
Compartment Confidence
mitochondrion 5
cytosol 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SDS: view

Pathways & Interactions for SDS Gene

genes like me logo Genes that share pathways with SDS: view

UniProtKB/Swiss-Prot P20132-SDHL_HUMAN

  • Pathway: Carbohydrate biosynthesis; gluconeogenesis.

Gene Ontology (GO) - Biological Process for SDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis IEA --
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006565 L-serine catabolic process IDA 15689518
GO:0042866 pyruvate biosynthetic process IDA 15689518
genes like me logo Genes that share ontologies with SDS: view

No data available for SIGNOR curated interactions for SDS Gene

Drugs & Compounds for SDS Gene

(32) Drugs for SDS Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist, Target 0
Citalopram Approved Pharma 520
Ammonia Approved Pharma 0
Water Approved Pharma 0
L-Threonine Approved Nutra 0

(3) Additional Compounds for SDS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Aminoacrylic acid
  • (alpha)-(beta)-di-dehydroalanine
  • 2-Aminoacrylate
  • 2-Aminoacrylic acid
  • a-b-Di-dehydroalanine
  • alpha-beta-Di-dehydroalanine
genes like me logo Genes that share compounds with SDS: view

Transcripts for SDS Gene

Unigene Clusters for SDS Gene

Serine dehydratase:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2: - -
SP3: -
SP4: - - - - -

Relevant External Links for SDS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDS Gene

This gene is overexpressed in Liver (x40.9).

Protein differential expression in normal tissues from HIPED for SDS Gene

This gene is overexpressed in Liver (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SDS Gene

Protein tissue co-expression partners for SDS Gene

NURSA nuclear receptor signaling pathways regulating expression of SDS Gene:


SOURCE GeneReport for Unigene cluster for SDS Gene:


Evidence on tissue expression from TISSUES for SDS Gene

  • Liver(4.9)
  • Lung(4.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SDS: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDS Gene

Orthologs for SDS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SDS 33 34
  • 99.49 (n)
(Bos Taurus)
Mammalia SDS 33 34
  • 83.75 (n)
(Mus musculus)
Mammalia Sds 33 16 34
  • 82.57 (n)
(Rattus norvegicus)
Mammalia Sds 33
  • 81.8 (n)
(Monodelphis domestica)
Mammalia SDS 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SDS 34
  • 67 (a)
(Anolis carolinensis)
Reptilia SDS 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sds 33
  • 67.29 (n)
Str.12213 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1669 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHA1 34
  • 31 (a)
SDL1 36
bread mold
(Neurospora crassa)
Ascomycetes NCU03761 33
  • 49.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
Species where no ortholog for SDS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SDS Gene

Gene Tree for SDS (if available)
Gene Tree for SDS (if available)

Paralogs for SDS Gene

Paralogs for SDS Gene

(1) SIMAP similar genes for SDS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SDS: view

Variants for SDS Gene

Sequence variations from dbSNP and Humsavar for SDS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000213283 -- 113,403,972(+) CCCCT(C/T)CCTCC upstream-variant-2KB
rs1000263857 -- 113,404,158(+) GACCC(C/T)CAACT upstream-variant-2KB
rs1000541369 -- 113,399,440(+) CTTGC(A/G)GGGAG intron-variant
rs1000914192 -- 113,404,252(+) TCAGA(C/G/T)GAAAG upstream-variant-2KB
rs1001137862 -- 113,393,201(+) GTGCA(C/T)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDS Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV gain+loss 19592680
esv3892265 CNV gain 25118596
esv3630792 CNV gain 21293372

Variation tolerance for SDS Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDS Gene

Disorders for SDS Gene

MalaCards: The human disease database

(1) MalaCards diseases for SDS Gene - From: DISEASES

Disorder Aliases PubMed IDs
autosomal dominant nonsyndromic deafness 69
  • autosomal dominant deafness 69
- elite association - COSMIC cancer census association via MalaCards
Search SDS in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SDS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDS Gene

Publications for SDS Gene

  1. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PMID: 18342636) Yamada T … Takusagawa F (Biochimica et biophysica acta 2008) 3 4 22 60
  2. Crystallization and preliminary crystallographic analysis of human serine dehydratase. (PMID: 14646100) Sun L … Rao Z (Acta crystallographica. Section D, Biological crystallography 2003) 3 4 22 60
  3. Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources. (PMID: 2674117) Ogawa H … Fujioka M (The Journal of biological chemistry 1989) 2 3 4 60
  4. Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy. (PMID: 18289528) Szaflik JP … Blasiak J (Experimental eye research 2008) 3 45 60
  5. Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver. (PMID: 15689518) Sun L … Rao Z (Protein science : a publication of the Protein Society 2005) 3 22 60

Products for SDS Gene

Sources for SDS Gene

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