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SDS Gene

protein-coding   GIFtS: 58
GCID: GC12M113830

Serine Dehydratase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine Dehydratase1 2     L-Serine Ammonia-Lyase2
SDH2 3 5     L-Serine Dehydratase2
TDH2 3     L-Serine Dehydratase/L-Threonine Deaminase2
L-Serine Deaminase2 3     EC 4.3.1.173
L-Threonine Dehydratase2 3     EC 4.3.1.193

External Ids:    HGNC: 106911   Entrez Gene: 109932   Ensembl: ENSG000001350947   OMIM: 1821285   UniProtKB: P201323   

Export aliases for SDS gene to outside databases

Previous GC identifers: GC12M112739 GC12M113349 GC12M113613 GC12M112242 GC12M112292 GC12M110841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SDS Gene:
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase
converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can
also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SDS Gene:
SDS (serine dehydratase) is a protein-coding gene. Diseases associated with SDS include shwachman-diamond syndrome, and hypervitaminosis a. GO annotations related to this gene include L-serine ammonia-lyase activity and protein homodimerization activity. An important paralog of this gene is SDSL.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SDS gene promoter:
         TBP   Spz1   AP-2alpha isoform 3   AP-1   ATF-2   AP-2alpha isoform 2   c-Jun   AP-2alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDS promoter sequence
   Search Chromatin IP Primers for SDS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.13

SDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M113830:  view genomic region     (about GC identifiers)

Start:
113,830,250 bp from pter      End:
113,864,106 bp from pter
Size:
33,857 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SDHL_HUMAN, P20132 (See protein sequence)
Recommended Name: L-serine dehydratase/L-threonine deaminase  
Size: 328 amino acids; 34625 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for SDS:
1P5J (3D)        4H27 (3D)    
Secondary accessions: A8K9P5

Explore the universe of human proteins at neXtProt for SDS: NX_P20132

Explore proteomics data for SDS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SDS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006834.2  
    ENSEMBL proteins: 
     ENSP00000257549   ENSP00000449833   ENSP00000449061  

    SDS Human Recombinant Protein Products:

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    Novus Biologicals SDS Protein
    Novus Biologicals SDS Lysates
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for SDS

    SDS Antibody Products:

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    SDS Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SDS
    Cloud-Clone Corp. CLIAs for SDS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF

    Graphical View of Domain Structure for InterPro Entry P20132

    ProtoNet protein and cluster: P20132

    2 Blocks protein domains:
    IPB000634 Serine/threonine dehydratase
    IPB001926 Pyridoxal-5'-phosphate-dependent enzyme


    UniProtKB/Swiss-Prot: SDHL_HUMAN, P20132
    Similarity: Belongs to the serine/threonine dehydratase family


    SDS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDHL_HUMAN, P20132
    Catalytic activity: L-serine = pyruvate + NH(3)
    Catalytic activity: L-threonine = 2-oxobutanoate + NH(3)
    Biophysicochemical properties: Kinetic parameters: KM=23 mM for serine; KM=31 mM for threonine;

         Genatlas biochemistry entry for SDS:
    serine dehydratase,liver,murine ortholog

         Enzyme Numbers (IUBMB): EC 4.3.1.171 EC 4.3.1.191

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003941L-serine ammonia-lyase activity IDA15689518
    GO:0004794L-threonine ammonia-lyase activity IEA--
    GO:0030170pyridoxal phosphate binding IDA15689518
    GO:0042803protein homodimerization activity IDA15689518
    GO:0046983protein dimerization activity ----
         
    SDS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SDS:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDS
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SDS
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    miRNA
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    Block miRNA regulation of human, mouse, rat SDS using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SDS:
    hsa-miR-508-5p hsa-miR-1261
    SwitchGear 3'UTR luciferase reporter plasmidSDS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SDS
    Predesigned siRNA for gene silencing in human, mouse, rat SDS

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SDHL_HUMAN, P20132: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol3
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    SDS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SDS About    
    See pathways by source

    SuperPathContained pathways About
    1Carbon metabolism
    Biosynthesis of amino acids0.38
    Valine, leucine and isoleucine biosynthesis0.00
    Carbon metabolism0.38
    L-serine degradation0.00
    2Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism
    glycine betaine degradation0.00
    3Metabolism
    Metabolic pathways0.38
    4Sulfur amino acid metabolism
    Cysteine and methionine metabolism0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SDS
        glycine betaine degradation
    L-serine degradation


    Selected Kegg Pathways  (Kegg details for SDS) (see all 6):
        Glycine, serine and threonine metabolism
    Cysteine and methionine metabolism
    Valine, leucine and isoleucine biosynthesis
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: SDHL_HUMAN, P20132
    Pathway: Carbohydrate biosynthesis; gluconeogenesis


    SDS for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SDS: 

              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SDS (P201323 ENSP000002575494) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006094gluconeogenesis IEA--
    GO:0006520cellular amino acid metabolic process ----
    GO:0006565L-serine catabolic process IDA15689518
    GO:0031667response to nutrient levels ----
    GO:0033590response to cobalamin IEA--

    SDS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SDS (SDHL)

    6 HMDB Compounds for SDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Aminoacrylic acidDehydroalanine (see all 6)----
    AmmoniaNH3 (see all 31)7664-41-7--
    L-Serine(-)-Serine (see all 26)56-45-1--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for SDS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Serine(-)-Serine (see all 11)56-45-1target--14688104 17139284 4377655 500557 17016423
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor14596599 15155761 15689518 16580895 14646100

    6 Novoseek inferred chemical compound relationships for SDS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetoacetate 70.6 5 15689518 (1), 18342636 (1)
    pyridoxal 5-phosphate 68.3 12 16580895 (1), 14646100 (1), 18342636 (1)
    serine 68.2 50 14646100 (3), 15618015 (3), 19887726 (2), 15689518 (2) (see all 17)
    pyruvate 64.7 14 19887726 (1), 17949340 (1), 14646100 (1), 15689518 (1) (see all 7)
    phosphoenolpyruvate 48.5 1 9239284 (1)
    threonine 45 4 16580895 (1), 15689518 (1), 8452219 (1)



    SDS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SDS gene: 
    NM_006843.2  

    Unigene Cluster for SDS:

    Serine dehydratase
    Hs.439023  [show with all ESTs]
    Unigene Representative Sequence: AK124290
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257549(uc001tvg.3) ENST00000553112(uc001tvh.1) ENST00000552280
    ENST00000547342 ENST00000546639 ENST00000546785
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SDS:
    hsa-miR-508-5p hsa-miR-1261
    SwitchGear 3'UTR luciferase reporter plasmidSDS 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK124290.1 AK292760.1 BC020750.1 J05037.1 

    5 DOTS entries:

    DT.95156558  DT.97838379  DT.99927232  DT.91981767  DT.121186761 

    Selected AceView cDNA sequences (see all 109):

    CR609930 BM727512 BQ184190 BM805738 CB161430 AK124290 AA427533 CB133212 
    BM856186 BX645273 CA307012 CB155931 CD623369 BM931914 BU740747 BX104228 
    BM684964 T28649 AW206387 F04480 CB163864 BG566257 CB138228 NM_006843 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SDS    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                    -           -                                       
    SP2:                    -           -                                       
    SP3:                    -                                                   
    SP4:                    -     -     -     -     -                           
    SP5:                                                                        


    ECgene alternative splicing isoforms for SDS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SDS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAACCCA
    SDS Expression
    About this image


    SDS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Periportal Hepatocytes Liver Lobule
             Human Hepatocyte (HH)   
    SDS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SDS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439023
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SDS: 
              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SDS gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sds1 , 5 serine dehydratase1, 5 82.57(n)1
    83.79(a)1
      5 (60.63 cM)5
    2316911  NM_145565.11  NP_663540.11 
     1204765315 
    lizard
    (Anolis carolinensis)
    Reptilia SDS6
    serine dehydratase
    59(a)
    1 ↔ 1
    GL343338.1(883486-895273)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16692 Xenopus laevis cDNA clone IMAGE6880181 72.55(n)    BC058326.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SDL1(YIL167W)4 Open reading frame, unlikely to produce a functional more   --   9(29416-30048)


    ENSEMBL Gene Tree for SDS (if available)
    TreeFam Gene Tree for SDS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SDS gene
    SDSL2  
    1 SIMAP similar gene for SDS using alignment to 3 protein entries:     SDHL_HUMAN (see all proteins):
    SDSL

    SDS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SDS (see all 359)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893492661,2
    --113829787(+) TGATAC/TGGGCT 1 -- ds50010--------
    rs340992851,2
    C,F--113829927(+) GGGAGG/CGGGCC 1 -- ds50014Minor allele frequency- C:0.07NA EA 248
    rs1384438881,2
    --113830035(+) CCTTCA/TGCGGA 1 -- ds50010--------
    rs1820075261,2
    --113830164(+) GGCCCC/TAGTTG 1 -- ds50010--------
    rs575702451,2
    C,F--113830266(+) AATATG/ATTTTA 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1837227021,2
    --113830329(+) GGCTTC/GCTGGG 1 -- ut310--------
    rs1884332661,2
    --113830338(+) GGAGGA/GTGGCT 1 -- ut310--------
    rs1461540981,2
    C--113830364(+) CCCTGA/GTTGGT 1 -- ut310--------
    rs1813087391,2
    --113830384(+) GACCTG/TCACTG 1 -- ut310--------
    rs1162775941,2
    C,F--113830444(+) GTGATT/GCAGGT 1 -- ut311Minor allele frequency- G:0.09WA 118

    HapMap Linkage Disequilibrium report for SDS (113830250 - 113864106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SDS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899528CNV Loss21882294
    nsv519540CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SDS
    DNA2.0 Custom Variant and Variant Library Synthesis for SDS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182128    OMIM disorders: --

    4 diseases for SDS:    
    About MalaCards
    shwachman-diamond syndrome    hypervitaminosis a    neuromuscular disease    diabetic retinopathy


    SDS for disorders           About GeneDecksing

    Genetic Association Database (GAD): SDS
    Human Genome Epidemiology (HuGE) Navigator: SDS (104 documents)

    Export disorders for SDS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SDS gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SDS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystallization and preliminary crystallographic analysis of human serine dehydratase. (PubMed id 14646100)1, 2, 7, 9 Sun L....Rao Z. (Acta Crystallogr. D 2003)
    2. Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources. (PubMed id 2674117)1, 2, 3 Ogawa H.... Fujioka M. (J. Biol. Chem. 1989)
    3. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PubMed id 18342636)1, 2, 9 Yamada T....Takusagawa F. (Biochim. Biophys. Acta 2008)
    4. Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver. (PubMed id 15689518)1, 7, 9 Sun L....Rao Z. (Protein Sci. 2005)
    5. Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy. (PubMed id 18289528)1, 4 Szaflik J.P....Blasiak J. (Exp. Eye Res. 2008)
    6. Enzymatic and biochemical properties of a novel human serine dehydratase isoform. (PubMed id 16580895)7, 9 Ogawa H....Kobayashi M. (Biochim. Biophys. Acta 2006)
    7. Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase. (PubMed id 10347152)1, 9 Xue H.H....Ichiyama A. (J. Biol. Chem. 1999)
    8. Modulating the function of human serine racemase and human serine dehydratase by protein engineering. (PubMed id 23112234)1 Wang C.Y....Wang A.H. (amp 2012)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10993 HGNC: 10691 AceView: SDS Ensembl:ENSG00000135094 euGenes: HUgn10993
    ECgene: SDS Kegg: 10993 H-InvDB: SDS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SDS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SDS gene:
    Search GeneIP for patents involving SDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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