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Aliases for SDS Gene

Aliases for SDS Gene

  • Serine Dehydratase 2 3 5
  • L-Threonine Dehydratase 3 4
  • L-Serine Ammonia-Lyase 2 3
  • L-Serine Deaminase 3 4
  • SDH 3 4
  • TDH 3 4
  • L-Serine Dehydratase 3
  • EC 4.3.1.17 4
  • EC 4.3.1.19 4

External Ids for SDS Gene

Previous GeneCards Identifiers for SDS Gene

  • GC12M112739
  • GC12M113349
  • GC12M113613
  • GC12M112242
  • GC12M112292
  • GC12M113830
  • GC12M110841

Summaries for SDS Gene

Entrez Gene Summary for SDS Gene

  • This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDS Gene

SDS (Serine Dehydratase) is a Protein Coding gene. Diseases associated with SDS include Shwachman-Diamond Syndrome and Aplastic Anemia. Among its related pathways are Sulfur amino acid metabolism and Carbon metabolism. GO annotations related to this gene include protein homodimerization activity and L-serine ammonia-lyase activity. An important paralog of this gene is SDSL.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDS Gene

Genomics for SDS Gene

Regulatory Elements for SDS Gene

Enhancers for SDS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SDS on UCSC Golden Path with GeneCards custom track

Genomic Location for SDS Gene

Chromosome:
12
Start:
113,392,445 bp from pter
End:
113,426,301 bp from pter
Size:
33,857 bases
Orientation:
Minus strand

Genomic View for SDS Gene

Genes around SDS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDS Gene

Proteins for SDS Gene

  • Protein details for SDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20132-SDHL_HUMAN
    Recommended name:
    L-serine dehydratase/L-threonine deaminase
    Protein Accession:
    P20132
    Secondary Accessions:
    • A8K9P5

    Protein attributes for SDS Gene

    Size:
    328 amino acids
    Molecular mass:
    34625 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SDS Gene

neXtProt entry for SDS Gene

Proteomics data for SDS Gene at MOPED

Post-translational modifications for SDS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDS Gene

Domains & Families for SDS Gene

Suggested Antigen Peptide Sequences for SDS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20132

UniProtKB/Swiss-Prot:

SDHL_HUMAN :
  • Belongs to the serine/threonine dehydratase family.
Family:
  • Belongs to the serine/threonine dehydratase family.
genes like me logo Genes that share domains with SDS: view

No data available for Gene Families for SDS Gene

Function for SDS Gene

Molecular function for SDS Gene

GENATLAS Biochemistry:
serine dehydratase,liver,murine ortholog
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=23 mM for serine {ECO:0000269 PubMed:18342636}; KM=31 mM for threonine {ECO:0000269 PubMed:18342636};
UniProtKB/Swiss-Prot CatalyticActivity:
L-serine = pyruvate + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
L-threonine = 2-oxobutanoate + NH(3).

Enzyme Numbers (IUBMB) for SDS Gene

Gene Ontology (GO) - Molecular Function for SDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003941 L-serine ammonia-lyase activity IDA 15689518
GO:0042803 protein homodimerization activity IDA 15689518
genes like me logo Genes that share ontologies with SDS: view
genes like me logo Genes that share phenotypes with SDS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SDS

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SDS Gene

Localization for SDS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDS Gene COMPARTMENTS Subcellular localization image for SDS gene
Compartment Confidence
mitochondrion 5
cytosol 4
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for SDS Gene

Pathways & Interactions for SDS Gene

genes like me logo Genes that share pathways with SDS: view

UniProtKB/Swiss-Prot P20132-SDHL_HUMAN

  • Pathway: Carbohydrate biosynthesis; gluconeogenesis.

Gene Ontology (GO) - Biological Process for SDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis IEA --
GO:0006565 L-serine catabolic process IDA 15689518
genes like me logo Genes that share ontologies with SDS: view

No data available for SIGNOR curated interactions for SDS Gene

Drugs & Compounds for SDS Gene

(29) Drugs for SDS Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist, Target 0
Citalopram Approved Pharma 497
L-Threonine Approved Nutra 0
Pyruvic acid Approved Nutra 0
2-Ketobutyric acid Experimental Pharma 0

(5) Additional Compounds for SDS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Aminoacrylic acid
  • (alpha)-(beta)-di-dehydroalanine
  • 2-Aminoacrylate
  • 2-Aminoacrylic acid
  • a-b-Di-dehydroalanine
  • alpha-beta-Di-dehydroalanine
28453-71-6
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with SDS: view

Transcripts for SDS Gene

Unigene Clusters for SDS Gene

Serine dehydratase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2: - -
SP3: -
SP4: - - - - -
SP5:

Relevant External Links for SDS Gene

GeneLoc Exon Structure for
SDS
ECgene alternative splicing isoforms for
SDS

Expression for SDS Gene

mRNA expression in normal human tissues for SDS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDS Gene

This gene is overexpressed in Liver (x40.9).

Protein differential expression in normal tissues from HIPED for SDS Gene

This gene is overexpressed in Liver (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SDS Gene



SOURCE GeneReport for Unigene cluster for SDS Gene Hs.439023

genes like me logo Genes that share expression patterns with SDS: view

Protein tissue co-expression partners for SDS Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SDS Gene

Orthologs for SDS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SDS 35
  • 83.75 (n)
  • 83.23 (a)
SDS 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sds 35
  • 82.57 (n)
  • 83.79 (a)
Sds 16
Sds 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SDS 35
  • 99.49 (n)
  • 99.09 (a)
SDS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sds 35
  • 81.8 (n)
  • 84.36 (a)
oppossum
(Monodelphis domestica)
Mammalia SDS 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDS 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDS 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sds 35
  • 67.29 (n)
  • 73.04 (a)
Str.12213 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1669 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHA1 36
  • 31 (a)
OneToMany
SDL1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU03761 35
  • 49.2 (n)
  • 39.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SDS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SDS Gene

ENSEMBL:
Gene Tree for SDS (if available)
TreeFam:
Gene Tree for SDS (if available)

Paralogs for SDS Gene

Paralogs for SDS Gene

(1) SIMAP similar genes for SDS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SDS: view

Variants for SDS Gene

Sequence variations from dbSNP and Humsavar for SDS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2069251 -- 113,399,323(+) TGGCT(C/T)AGGAA intron-variant
rs7135256 -- 113,405,318(+) ctttt(C/T)tgcgt upstream-variant-2KB
rs7135290 -- 113,405,393(+) ccttt(C/T)tggag upstream-variant-2KB
rs7135421 -- 113,405,515(+) ctggt(C/T)ttaat upstream-variant-2KB
rs7135675 -- 113,405,668(+) caaat(C/T)tgaag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDS Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV Gain+Loss 19592680
nsv899528 CNV Loss 21882294

Variation tolerance for SDS Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SDS Gene

Disorders for SDS Gene

MalaCards: The human disease database

(2) MalaCards diseases for SDS Gene - From: OMIM

Disorder Aliases PubMed IDs
shwachman-diamond syndrome
  • pancreatic insufficiency and bone marrow dysfunction
aplastic anemia
  • pulmonary fibrosis, idiopathic
- elite association - COSMIC cancer census association via MalaCards
Search SDS in MalaCards View complete list of genes associated with diseases

Relevant External Links for SDS

Genetic Association Database (GAD)
SDS
Human Genome Epidemiology (HuGE) Navigator
SDS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDS
genes like me logo Genes that share disorders with SDS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDS Gene

Publications for SDS Gene

  1. Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources. (PMID: 2674117) Ogawa H. … Fujioka M. (J. Biol. Chem. 1989) 2 3 4 67
  2. Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver. (PMID: 15689518) Sun L. … Rao Z. (Protein Sci. 2005) 3 23 25
  3. Crystallization and preliminary crystallographic analysis of human serine dehydratase. (PMID: 14646100) Sun L. … Rao Z. (Acta Crystallogr. D 2003) 3 23 25
  4. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PMID: 18342636) Yamada T. … Takusagawa F. (Biochim. Biophys. Acta 2008) 3 23
  5. Enzymatic and biochemical properties of a novel human serine dehydratase isoform. (PMID: 16580895) Ogawa H. … Kobayashi M. (Biochim. Biophys. Acta 2006) 23 25

Products for SDS Gene

Sources for SDS Gene

Content