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Aliases for SDS Gene

Aliases for SDS Gene

  • Serine Dehydratase 2 3
  • SDH 3 4 6
  • L-Threonine Dehydratase 3 4
  • L-Serine Ammonia-Lyase 2 3
  • L-Serine Deaminase 3 4
  • TDH 3 4
  • L-Serine Dehydratase/L-Threonine Deaminase 3
  • L-Serine Dehydratase 3
  • EC 4
  • EC 4

External Ids for SDS Gene

Previous GeneCards Identifiers for SDS Gene

  • GC12M112739
  • GC12M113613
  • GC12M112242
  • GC12M112292
  • GC12M113830
  • GC12M110841

Summaries for SDS Gene

Entrez Gene Summary for SDS Gene

  • This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDS Gene

SDS (Serine Dehydratase) is a Protein Coding gene. Diseases associated with SDS include shwachman-bodian-diamond syndrome. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and L-serine ammonia-lyase activity. An important paralog of this gene is SDSL.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDS Gene

Genomics for SDS Gene

Regulatory Elements for SDS Gene

Genomic Location for SDS Gene

113,392,445 bp from pter
113,426,301 bp from pter
33,857 bases
Minus strand

Genomic View for SDS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDS Gene

Proteins for SDS Gene

  • Protein details for SDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    L-serine dehydratase/L-threonine deaminase
    Protein Accession:
    Secondary Accessions:
    • A8K9P5

    Protein attributes for SDS Gene

    328 amino acids
    Molecular mass:
    34625 Da
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SDS Gene

neXtProt entry for SDS Gene

Proteomics data for SDS Gene at MOPED

Post-translational modifications for SDS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SDS Gene

Domains for SDS Gene

Suggested Antigen Peptide Sequences for SDS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serine/threonine dehydratase family.
  • Belongs to the serine/threonine dehydratase family.
genes like me logo Genes that share domains with SDS: view

No data available for Gene Families for SDS Gene

Function for SDS Gene

Molecular function for SDS Gene

GENATLAS Biochemistry:
serine dehydratase,liver,murine ortholog
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=23 mM for serine {ECO:0000269 PubMed:18342636}; KM=31 mM for threonine {ECO:0000269 PubMed:18342636};
UniProtKB/Swiss-Prot CatalyticActivity:
L-serine = pyruvate + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
L-threonine = 2-oxobutanoate + NH(3).

Enzyme Numbers (IUBMB) for SDS Gene

Gene Ontology (GO) - Molecular Function for SDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003941 L-serine ammonia-lyase activity IDA 15689518
GO:0004794 L-threonine ammonia-lyase activity IBA --
GO:0030170 pyridoxal phosphate binding IDA 15689518
GO:0042803 protein homodimerization activity IDA 15689518
genes like me logo Genes that share ontologies with SDS: view

Phenotypes for SDS Gene

GenomeRNAi human phenotypes for SDS:
genes like me logo Genes that share phenotypes with SDS: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SDS Gene

Localization for SDS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDS Gene


Subcellular locations from

Jensen Localization Image for SDS Gene COMPARTMENTS Subcellular localization image for SDS gene
Compartment Confidence
mitochondrion 4
cytosol 3
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with SDS: view

Pathways for SDS Gene

genes like me logo Genes that share pathways with SDS: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P20132-SDHL_HUMAN

  • Pathway: Carbohydrate biosynthesis; gluconeogenesis

Gene Ontology (GO) - Biological Process for SDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis IEA --
GO:0006520 cellular amino acid metabolic process --
GO:0006565 L-serine catabolic process IDA 15689518
GO:0006567 threonine catabolic process IBA --
GO:0042866 pyruvate biosynthetic process IDA 15689518
genes like me logo Genes that share ontologies with SDS: view

Drugs for SDS Gene

(2) Drugbank Compounds for SDS Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2S)-2-amino-3-Hydroxypropanoic acid
56-45-1 Target approved, nutraceutical
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 1051 Target cofactor nutraceutical

(8) HMDB Compounds for SDS Gene

Compound Synonyms Cas Number PubMed IDs
2-Aminoacrylic acid
  • (alpha)-(beta)-di-dehydroalanine
2-Ketobutyric acid
  • 2-Ketobutanoate
  • Ammonia anhydrous
  • (-)-Serine
  • (2S,3R)-(-)-Threonine

(6) Novoseek inferred chemical compound relationships for SDS Gene

Compound -log(P) Hits PubMed IDs
acetoacetate 70.6 2
pyridoxal 5-phosphate 68.3 3
serine 68.2 26
pyruvate 64.7 7
phosphoenolpyruvate 48.5 1
genes like me logo Genes that share compounds with SDS: view

Transcripts for SDS Gene

Unigene Clusters for SDS Gene

Serine dehydratase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2: - -
SP3: -
SP4: - - - - -

Relevant External Links for SDS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDS Gene

mRNA expression in normal human tissues for SDS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDS Gene

This gene is overexpressed in Liver (40.9).

Protein differential expression in normal tissues for SDS Gene

This gene is overexpressed in Liver (65.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SDS Gene

SOURCE GeneReport for Unigene cluster for SDS Gene Hs.439023

genes like me logo Genes that share expressions with SDS: view

Expression partners for SDS Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SDS Gene

Orthologs for SDS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SDS 35
  • 83.75 (n)
  • 83.23 (a)
SDS 36
  • 82 (a)
(Mus musculus)
Mammalia Sds 35
  • 82.57 (n)
  • 83.79 (a)
Sds 16
Sds 36
  • 83 (a)
(Pan troglodytes)
Mammalia SDS 35
  • 99.49 (n)
  • 99.09 (a)
SDS 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sds 35
  • 81.8 (n)
  • 84.36 (a)
(Monodelphis domestica)
Mammalia SDS 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SDS 36
  • 67 (a)
(Anolis carolinensis)
Reptilia SDS 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sds 35
  • 67.29 (n)
  • 73.04 (a)
Str.12213 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1669 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHA1 36
  • 31 (a)
SDL1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU03761 35
  • 49.2 (n)
  • 39.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for SDS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SDS Gene

Gene Tree for SDS (if available)
Gene Tree for SDS (if available)

Paralogs for SDS Gene

Paralogs for SDS Gene

(1) SIMAP similar genes for SDS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SDS: view

Variants for SDS Gene

Sequence variations from dbSNP and Humsavar for SDS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1050062 -- 113,393,982(-) TGGGG(G/T)CTCAG reference, missense
rs2069251 -- 113,399,323(+) TGGCT(C/T)AGGAA intron-variant
rs2303622 -- 113,399,551(+) GGTCC(C/T)GTACC intron-variant
rs3794315 -- 113,398,190(+) CTTAG(C/T)CTCCC intron-variant
rs3812826 -- 113,392,852(+) CTCAG(C/T)CAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SDS Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV Gain+Loss 19592680
nsv899528 CNV Loss 21882294

Relevant External Links for SDS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDS Gene

Disorders for SDS Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SDS Gene in MalaCards »

(1) Disease for SDS Gene

Relevant External Links for SDS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SDS: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SDS Gene

Publications for SDS Gene

  1. Crystallization and preliminary crystallographic analysis of human serine dehydratase. (PMID: 14646100) Sun L. … Rao Z. (Acta Crystallogr. D 2003) 3 4 23 25
  2. Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources. (PMID: 2674117) Ogawa H. … Fujioka M. (J. Biol. Chem. 1989) 2 3 4
  3. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. (PMID: 18342636) Yamada T. … Takusagawa F. (Biochim. Biophys. Acta 2008) 3 4 23
  4. Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver. (PMID: 15689518) Sun L. … Rao Z. (Protein Sci. 2005) 3 23 25
  5. Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy. (PMID: 18289528) Szaflik J.P. … Blasiak J. (Exp. Eye Res. 2008) 3 48

Products for SDS Gene

Sources for SDS Gene

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