SDR9C7 Gene
protein-coding GIFtS : 48
GCID: GC12 M057316
short chain dehydrogenase/reductase family 9C, member 7
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Aliasesfor SDR9C7 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Short Chain Dehydrogenase/Reductase Family 9C, Member 7 1 2 Orphan Short-Chain Dehydrogenase / Reductase2 RDHS1 2 3 Retinol Dehydrogenase Similar Protein2 SDR-O1 2 3 Short-Chain Dehydrogenase/Reductase Family 9C Member 72 SDRO2 3 5 EC 1.1.1.-3 Orphan Short-Chain Dehydrogenase/Reductase2 3 EC 1.1.18 RDH-S2 3
Export aliases for SDR9C7 gene to outside databases Previous GC identifers: GC12M055604 GC12M054355
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Summariesfor SDR9C7 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SDR9C7 : This gene encodes a protein with similarity to the short-chain dehydrogenase/reductase (SDR) family but has not been shown to have retinoid or dehydrogenase activities. (provided by RefSeq, Apr 2010) UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9 Function : Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently nosteroid dehydrogenase activity
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Genomic Viewsfor SDR9C7 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SDR9C7 gene promoter: c-Fos p53 Pax-5 AP-1 HNF-1A Ik-2 FOXO4 HNF-1 c-Jun AP-2alpha Other transcription factors Search SABiosciences Chromatin IP Primers for SDR9C7 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDR9C7
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3 SDR9C7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M057316: view genomic region
(about GC identifiers )
Start:
57,316,938 bp from pter
End:
57,328,189 bp from pter
Size:
11,252 bases
Orientation:
minus strand
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Proteinsfor SDR9C7 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9 (See
protein sequence )Recommended Name: Short-chain dehydrogenase/reductase family 9C member 7 Size : 313 amino acids; 35263 Da
Subcellular location : Cytoplasm. Note=Granular distribution in the whole cell
Secondary accessions : B3KVB4Explore the universe of human proteins at neXtProt for SDR9C7: NX_Q8NEX9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8NEX9 2 DME Specific Peptides for SDR9C7 (Q8NEX9 ) SDR9C7 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_683695.1 ENSEMBL proteins: ENSP00000293502 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
SDR9C7 for ontologies About GeneDecksing SDR9C7 Antibody Products: Assay Products for SDR9C7:
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Protein
Domains / Familiesfor SDR9C7 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SDR9C7 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8NEX9 ProtoNet protein and cluster: Q8NEX9
2 Blocks protein families : IPB002198 Short-chain dehydrogenase/reductase SDR IPB002347 Glucose/ribitol dehydrogenase family signature UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9 Similarity : Belongs to the short-chain dehydrogenases/reductases (SDR) family
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Functionfor SDR9C7 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9 Function : Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently nosteroid dehydrogenase activity Enzyme Numbers (IUBMB): EC 1.1.1 2 EC 1.1.1.- 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SDR9C7 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SDR9C7OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SDR9C7 (NM_148897 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDR9C7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SDR9C7
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR9C7
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
SDR9C7 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for SDR9C7 :
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Pathways & Interactionsfor SDR9C7 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDR9C7 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
SDR9C7 for ontologies About GeneDecksing
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Drugs & Compoundsfor SDR9C7 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SDR9C7 Search CenterWatch for drugs/clinical trials and news about SDR9C7 / DR9C7
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Transcriptsfor SDR9C7 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SDR9C7 gene: NM_148897.2 Unigene Cluster for SDR9C7:
Short chain dehydrogenase/reductase family 9C, member 7 Hs.380178 [show with all ESTs ] Unigene Representative Sequence: AK122782 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000293502 (uc010sqw.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SDR9C7 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SDR9C7OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SDR9C7 (NM_148897 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDR9C7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SDR9C7
Additional cDNA sequence: AK122782.1 AY044434.1 BC101551.1 BC101553.1
1 DOTS entry : DT.100000554
4 AceView cDNA sequences :
AY044434 NM_148897 AK122782 BU531963 GeneLoc Exon Structure
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Expression for SDR9C7 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SDR9C7 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAATAACATT
About this image SDR9C7 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor EN2 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SDR9C7 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SDR9C7 SOURCE GeneReport for Unigene cluster: Hs.380178 UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9 Tissue specificity : Highly expressed in liver SABiosciences Custom PCR Arrays for SDR9C7 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SDR9C7Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SDR9C7 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SDR9C7 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SDR9C7 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR9C7
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Orthologsfor SDR9C7 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SDR9C7 gene from 7/20 species (see all 20 ) About this table
ENSEMBL Gene Tree for SDR9C7 (if available)TreeFam Gene Tree for SDR9C7 (if available)
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Paralogsfor SDR9C7 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SDR9C7 gene DHRS9 2 HSD11B2 2 HSD17B6 2 HSD17B2 2 BDH1 2 RDH8 2 RDH16 2 DHRS7 2 DHRS7B 2 HSD17B1 2 KDSR 2 DHRS7C 2 RDH5 2 7 SIMAP similar genes for SDR9C7 using alignment to 1 protein entry: DR9C7_HUMAN :RDH16 HSD17B6 RDHL RDH5 DHRS9 BDH1 HSD17B2
SDR9C7 for paralogs About GeneDecksing
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Genomic Variantsfor SDR9C7 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SDR9C7 (57316938 - 57328189 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for SDR9C7 1 CNV : 1914
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SDR9C7
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Disorders
/ Diseasesfor SDR9C7 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SDR9C7 for disorders About GeneDecksing
OMIM gene information: 609769
OMIM disorders : --6 diseases for SDR9C7 : About MalaCards fundus albipunctatus leber congenital amaurosis fundus dystrophy retinitis tuberculosis mycobacterium tuberculosis 1 disease from the University of Copenhagen DISEASES database for SDR9C7 :Fundus dystrophy Export disorders for SDR9C7 gene to outside databases
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Publicationsfor SDR9C7 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SDR9C7 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with SDR9C7) Utopia : connect your pdf to the dynamic world of online information
SDR-O: an orphan short-chain dehydrogenase/reductase localized at mouse chromosome 10/human chromosome 12. (PubMed id 12234675) 1 , 2 , 3, 9 Chen W.... Napoli J.L. (2002) The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726) 1 , 2 , 3 Persson B.... Oppermann U. (2009) In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O). (PubMed id 19703561) 1 , 2 , 9 Kowalik D.... Moeller G. (2009) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism. (PubMed id 19011747) 9 ParAcs X....Duester G. (2008) Redundant and unique roles of retinol dehydrogenases in the mouse retina. (PubMed id 18048336) 9 Maeda A....Palczewski K. (2007) Rdh12 activity and effects on retinoid processing in the murine retina. (PubMed id 19506076) 9 Chrispell J.D....Thompson D.A. (2009)
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External Searches for SDR9C7 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SDR9C7 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SDR9C7 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SDR9C7 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SDR9C7 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SDR9C7 gene: Search GeneIP for patents involving SDR9C7 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SDR9C7 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for SDR9C7 OriGene shRNA RFP for SDR9C7 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SDR9C7 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SDR9C7 OriGene Protein Over-expression Lysate for SDR9C7 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SDR9C7 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SDR9C7 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SDR9C7 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SDR9C7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SDR9C7 OriGene Custom Protein Services for SDR9C7 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDR9C7 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SDR9C7 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDR9C7 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SDR9C7 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SDR9C7 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SDR9C7
Search Tocris compounds for SDR9C7
SDR9C7 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR9C7
Search ThermoFisher Antibodies for SDR9C7
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SDR9C7
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