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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SDR9C7 Gene

protein-coding   GIFtS: 48
GCID: GC12M057316

short chain dehydrogenase/reductase family 9C, member 7

 Explore 6 diseases affiliated with
SDR9C7 via our new
 Human Malady Compendium 
Biological research products
for SDR9C7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Short Chain Dehydrogenase/Reductase Family 9C, Member 71 2     Orphan Short-Chain Dehydrogenase / Reductase2
RDHS1 2 3     Retinol Dehydrogenase Similar Protein2
SDR-O1 2 3     Short-Chain Dehydrogenase/Reductase Family 9C Member 72
SDRO2 3 5     EC 1.1.1.-3
Orphan Short-Chain Dehydrogenase/Reductase2 3     EC 1.1.18
RDH-S2 3     

External Ids:    HGNC: 299581   Entrez Gene: 1212142   Ensembl: ENSG000001704267   OMIM: 6097695   UniProtKB: Q8NEX93   

Export aliases for SDR9C7 gene to outside databases

Previous GC identifers: GC12M055604 GC12M054355


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SDR9C7:
This gene encodes a protein with similarity to the short-chain dehydrogenase/reductase (SDR) family but has not been
shown to have retinoid or dehydrogenase activities. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9
Function: Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no
steroid dehydrogenase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SDR9C7 gene promoter:
         c-Fos   p53   Pax-5   AP-1   HNF-1A   Ik-2   FOXO4   HNF-1   c-Jun   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDR9C7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SDR9C7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDR9C7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

SDR9C7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDR9C7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057316:  view genomic region     (about GC identifiers)

Start:
57,316,938 bp from pter      End:
57,328,189 bp from pter
Size:
11,252 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9 (See protein sequence)
Recommended Name: Short-chain dehydrogenase/reductase family 9C member 7  
Size: 313 amino acids; 35263 Da
Subcellular location: Cytoplasm. Note=Granular distribution in the whole cell
Secondary accessions: B3KVB4

Explore the universe of human proteins at neXtProt for SDR9C7: NX_Q8NEX9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NEX9

  • 2 DME Specific Peptides for SDR9C7 (Q8NEX9)
     GVEAFSD  TGCDSGFG 

    SDR9C7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_683695.1  
    ENSEMBL proteins: 
     ENSP00000293502  

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    Uscn Proteins for SDR9C7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--


    SDR9C7 for ontologies           About GeneDecksing



    SDR9C7 Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SDR9C7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8NEX9

    ProtoNet protein and cluster: Q8NEX9

    2 Blocks protein families:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9
    Function: Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no
    steroid dehydrogenase activity

    Enzyme Numbers (IUBMB): EC 1.1.12 EC 1.1.1.-1

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0004745retinol dehydrogenase activity IDA19703561


    SDR9C7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SDR9C7:
     Decreased cilium length after  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDR9C7

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process IDA19703561


    SDR9C7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SDR9C7
    Search CenterWatch for drugs/clinical trials and news about SDR9C7 / DR9C7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SDR9C7 gene: 
    NM_148897.2  

    Unigene Cluster for SDR9C7:

    Short chain dehydrogenase/reductase family 9C, member 7
    Hs.380178  [show with all ESTs]
    Unigene Representative Sequence: AK122782
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000293502(uc010sqw.2)

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    Additional cDNA sequence: 

    AK122782.1 AY044434.1 BC101551.1 BC101553.1 

    1 DOTS entry:

    DT.100000554 

    4 AceView cDNA sequences:

    AY044434 NM_148897 AK122782 BU531963 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SDR9C7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATAACATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SDR9C7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SDR9C7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SDR9C7

    SOURCE GeneReport for Unigene cluster: Hs.380178

    UniProtKB/Swiss-Prot: DR9C7_HUMAN, Q8NEX9
    Tissue specificity: Highly expressed in liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR9C7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SDR9C7 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves F1NB59_CHICK6
    Uncharacterized protein
    20(a)
    possible ortholog
    8(14638970-14645915)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 10)
    --
    55(a)
    55(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    2(95003068-95011458)
    2(95074571-95078789)
    zebrafish
    (Danio rerio)
    Actinopterygii hsd17b16
    rdh8b6
    (see all 6)
    retinol dehydrogenase 8b
    (see all 6)
    25(a)
    22(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    3(17769528-17776030)
    1(60269731-60279318)
    worm
    (Caenorhabditis elegans)
    Secernentea F55E10.66
    dhs-206
    (see all 4)
    Protein F55E10.6
    DeHydrogenases, Short chain family member (dhs-20)...
    (see all 4)
    33(a)
    32(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(8344648-8346307)
    V(11602294-11604545)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G652056
    AT5G100506
    1-acylglycerone phosphate reductase
    21(a)
    21(a)
    possible ortholog
    possible ortholog
    5(26050810-26052034)
    5(3144200-3145730)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    oxidoreductase, short chain dehydrogenase/reductas...
    oxidoreductase, short chain dehydrogenase/reductas...
    22(a)
    21(a)
    possible ortholog
    possible ortholog
    12(27135120-27136028)
    4(22652738-22655412)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria ybbO6
    predicted oxidoreductase with NAD(P)-binding Rossm...
    26(a)
    possible ortholog
    Chromosome(517564-518373)


    ENSEMBL Gene Tree for SDR9C7 (if available)
    TreeFam Gene Tree for SDR9C7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SDR9C7 gene
    DHRS92  HSD11B22  HSD17B62  HSD17B22  BDH12  RDH82  RDH162  DHRS72  
    DHRS7B2  HSD17B12  KDSR2  DHRS7C2  RDH52  
    7 SIMAP similar genes for SDR9C7 using alignment to 1 protein entry:     DR9C7_HUMAN:
    RDH16    HSD17B6    RDHL    RDH5    DHRS9    BDH1
    HSD17B2

    SDR9C7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/256 NCBI SNPs in SDR9C7 are shown (see all 256    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772181701,2
    F,--57316470(+) AATTTG/CAGAAA 1 -- ds50013Minor allele frequency- C:0.22CSA WA 122
    rs1815058251,2
    --57316581(+) TTCCCA/CCTCTG 1 -- ds50010--------
    rs1170275761,2
    C,F,--57316603(+) NNNNAT/GTCTAT 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1868071081,2
    --57316614(+) GGAATA/TATTGG 1 -- ds50010--------
    rs1489688411,2
    --57316623(+) GGTGGC/TTCCAA 1 -- ds50010--------
    rs1921112301,2
    --57316632(+) AAGTTG/TCTCGG 1 -- ds50010--------
    rs1821260051,2
    --57316635(+) TTGCTC/TGGGTG 1 -- ds50010--------
    rs1437687761,2
    --57316659(+) TAGGTC/GCTTGT 1 -- ds50010--------
    rs1876728031,2
    --57316693(+) TATCTC/TAGTCC 1 -- ds50010--------
    rs1166481401,2
    --57316852(+) CTTCTA/GTCGCT 1 -- ds50011Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for SDR9C7 (57316938 - 57328189 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SDR9C7
         1 CNV: 1914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SDR9C7 for disorders           About GeneDecksing

    OMIM gene information: 609769    OMIM disorders: --

    6 diseases for SDR9C7:    About MalaCards
    fundus albipunctatus    leber congenital amaurosis    fundus dystrophy    retinitis
    tuberculosis    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for SDR9C7:
    Fundus dystrophy

    Export disorders for SDR9C7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SDR9C7 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with SDR9C7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SDR-O: an orphan short-chain dehydrogenase/reductase localized at mouse chromosome 10/human chromosome 12. (PubMed id 12234675)1, 2, 3, 9 Chen W.... Napoli J.L. (2002)
    2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 2, 3 Persson B.... Oppermann U. (2009)
    3. In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O). (PubMed id 19703561)1, 2, 9 Kowalik D.... Moeller G. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism. (PubMed id 19011747)9 ParAcs X....Duester G. (2008)
    9. Redundant and unique roles of retinol dehydrogenases in the mouse retina. (PubMed id 18048336)9 Maeda A....Palczewski K. (2007)
    10. Rdh12 activity and effects on retinoid processing in the murine retina. (PubMed id 19506076)9 Chrispell J.D....Thompson D.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 121214 HGNC: 29958 AceView: SDR-O Ensembl:ENSG00000170426 euGenes: HUgn121214
    ECgene: SDR9C7 H-InvDB: SDR9C7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SDR9C7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SDR9C7 gene:
    Search GeneIP for patents involving SDR9C7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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