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Aliases for SDR9C7 Gene

Aliases for SDR9C7 Gene

  • Short Chain Dehydrogenase/Reductase Family 9C Member 7 2 3 5
  • Orphan Short-Chain Dehydrogenase/Reductase 3 4
  • RDH-S 3 4
  • SDR-O 3 4
  • RDHS 3 4
  • SDRO 3 4
  • Short Chain Dehydrogenase/Reductase Family 9C, Member 7 2
  • Short-Chain Dehydrogenase/Reductase Family 9C Member 7 3
  • Orphan Short-Chain Dehydrogenase / Reductase 3
  • Retinol Dehydrogenase Similar Protein 3
  • EC 1.1.1.- 4
  • EC 1.1.1 61

External Ids for SDR9C7 Gene

Previous GeneCards Identifiers for SDR9C7 Gene

  • GC12M055604
  • GC12M057316
  • GC12M054355

Summaries for SDR9C7 Gene

Entrez Gene Summary for SDR9C7 Gene

  • This gene encodes a protein with similarity to the short-chain dehydrogenase/reductase (SDR) family but has not been shown to have retinoid or dehydrogenase activities. [provided by RefSeq, Apr 2010]

GeneCards Summary for SDR9C7 Gene

SDR9C7 (Short Chain Dehydrogenase/Reductase Family 9C Member 7) is a Protein Coding gene. Diseases associated with SDR9C7 include Ichthyosis, Congenital, Autosomal Recessive 7 and Ichthyosis, Congenital, Autosomal Recessive 1. Among its related pathways are the visual cycle I (vertebrates) and Metabolism of fat-soluble vitamins. GO annotations related to this gene include oxidoreductase activity and retinol dehydrogenase activity. An important paralog of this gene is RDH16.

UniProtKB/Swiss-Prot for SDR9C7 Gene

  • Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDR9C7 Gene

Genomics for SDR9C7 Gene

Regulatory Elements for SDR9C7 Gene

Enhancers for SDR9C7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G056987 1.3 Ensembl ENCODE 16 -54.1 -54073 2.2 PKNOX1 ARNT ARID4B ZNF766 CBX5 ZNF143 DEK REST SMARCB1 ZNF592 MYO1A SDR9C7 ESYT1 CTDSP2 RDH16 LOC390332 GPR182
GH12G056985 1.1 Ensembl ENCODE 15.5 -51.6 -51588 1.5 CTCF PKNOX1 NFIB JUN SIN3A RAD21 TEAD3 FOSL1 GATA3 FOSL2 SDR9C7 LOC390332 GPR182
GH12G056835 1.3 Ensembl ENCODE 10.3 +97.7 97713 1.4 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS SP3 ANKRD52 NEMP1 TSPAN31 ENSG00000212383 BAZ2A GPR182 RDH16 ENSG00000224713 SDR9C7 ENSG00000273536
GH12G057001 1 ENCODE 10.1 -67.2 -67217 0.2 HDGF FOXA2 MLX ARID4B SIN3A ZNF2 ZNF48 ZNF143 REST MIER2 MYO1A NAB2 SDR9C7 MARCH9 NACA HBCBP PIR61192
GH12G056930 1.4 FANTOM5 Ensembl ENCODE 7.2 +2.0 1970 2.9 HDGF HDAC1 CBX3 RB1 TBL1XR1 NFRKB DEAF1 CHAMP1 GATA2 ZNF548 NEMP1 BAZ2A CTDSP2 ENSG00000258317 RN7SL809P RNU6-343P STAT2 RBMS2 ZC3H10 CDK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDR9C7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SDR9C7 Gene

Chromosome:
12
Start:
56,923,154 bp from pter
End:
56,934,405 bp from pter
Size:
11,252 bases
Orientation:
Minus strand

Genomic View for SDR9C7 Gene

Genes around SDR9C7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDR9C7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDR9C7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDR9C7 Gene

Proteins for SDR9C7 Gene

  • Protein details for SDR9C7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEX9-DR9C7_HUMAN
    Recommended name:
    Short-chain dehydrogenase/reductase family 9C member 7
    Protein Accession:
    Q8NEX9
    Secondary Accessions:
    • B3KVB4

    Protein attributes for SDR9C7 Gene

    Size:
    313 amino acids
    Molecular mass:
    35263 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SDR9C7 Gene

Selected DME Specific Peptides for SDR9C7 Gene

Q8NEX9:
  • GVEAFSD
  • TGCDSGFG

Post-translational modifications for SDR9C7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDR9C7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SDR9C7 Gene

Gene Families for SDR9C7 Gene

Suggested Antigen Peptide Sequences for SDR9C7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEX9

UniProtKB/Swiss-Prot:

DR9C7_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with SDR9C7: view

Function for SDR9C7 Gene

Molecular function for SDR9C7 Gene

UniProtKB/Swiss-Prot Function:
Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity.

Enzyme Numbers (IUBMB) for SDR9C7 Gene

Gene Ontology (GO) - Molecular Function for SDR9C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity IDA 19703561
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with SDR9C7: view
genes like me logo Genes that share phenotypes with SDR9C7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SDR9C7

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDR9C7 Gene

Localization for SDR9C7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDR9C7 Gene

Cytoplasm. Note=Granular distribution in the whole cell.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDR9C7 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SDR9C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SDR9C7: view

Pathways & Interactions for SDR9C7 Gene

genes like me logo Genes that share pathways with SDR9C7: view

Pathways by source for SDR9C7 Gene

Gene Ontology (GO) - Biological Process for SDR9C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA,IDA 19703561
genes like me logo Genes that share ontologies with SDR9C7: view

No data available for SIGNOR curated interactions for SDR9C7 Gene

Drugs & Compounds for SDR9C7 Gene

No Compound Related Data Available

Transcripts for SDR9C7 Gene

mRNA/cDNA for SDR9C7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SDR9C7 Gene

Short chain dehydrogenase/reductase family 9C, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDR9C7 Gene

No ASD Table

Relevant External Links for SDR9C7 Gene

GeneLoc Exon Structure for
SDR9C7
ECgene alternative splicing isoforms for
SDR9C7

Expression for SDR9C7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDR9C7 Gene

mRNA differential expression in normal tissues according to GTEx for SDR9C7 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x17.8), Skin - Not Sun Exposed (Suprapubic) (x15.4), Vagina (x7.0), and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for SDR9C7 Gene

This gene is overexpressed in Cervix (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SDR9C7 Gene



Protein tissue co-expression partners for SDR9C7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SDR9C7 Gene:

SDR9C7

SOURCE GeneReport for Unigene cluster for SDR9C7 Gene:

Hs.380178

mRNA Expression by UniProt/SwissProt for SDR9C7 Gene:

Q8NEX9-DR9C7_HUMAN
Tissue specificity: Highly expressed in liver.

Evidence on tissue expression from TISSUES for SDR9C7 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with SDR9C7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDR9C7 Gene

Orthologs for SDR9C7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SDR9C7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDR9C7 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia SDR9C7 34 35
  • 89.56 (n)
cow
(Bos Taurus)
Mammalia SDR9C7 34 35
  • 89.03 (n)
mouse
(Mus musculus)
Mammalia Sdr9c7 34 16 35
  • 83.6 (n)
rat
(Rattus norvegicus)
Mammalia Sdr9c7 34
  • 83.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SDR9C7 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dhrs9 35
  • 45 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.691 34
Species where no ortholog for SDR9C7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDR9C7 Gene

ENSEMBL:
Gene Tree for SDR9C7 (if available)
TreeFam:
Gene Tree for SDR9C7 (if available)

Paralogs for SDR9C7 Gene

(7) SIMAP similar genes for SDR9C7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SDR9C7: view

Variants for SDR9C7 Gene

Sequence variations from dbSNP and Humsavar for SDR9C7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000083970 -- 56,932,836(+) AATCT(A/G)TTGTA intron-variant
rs1000226111 -- 56,928,935(+) CTAAC(C/T)CTCAT intron-variant
rs1000389090 -- 56,926,238(+) CGATG(A/C)TCTAG intron-variant
rs1000458918 -- 56,935,445(+) ATGAG(C/T)CTGGT upstream-variant-2KB
rs1000501566 -- 56,923,827(+) TCCTC(C/T)CCAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SDR9C7 Gene

Variant ID Type Subtype PubMed ID
nsv1043846 CNV gain 25217958
nsv438213 CNV loss 16468122
nsv482992 CNV gain+loss 15286789

Variation tolerance for SDR9C7 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDR9C7 Gene

Human Gene Mutation Database (HGMD)
SDR9C7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDR9C7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDR9C7 Gene

Disorders for SDR9C7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SDR9C7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ichthyosis, congenital, autosomal recessive 7
  • autosomal recessive congenital ichthyosis 7
ichthyosis, congenital, autosomal recessive 1
  • autosomal recessive congenital ichthyosis 1
autosomal recessive congenital ichthyosis
  • arci
fundus dystrophy
  • retinal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SDR9C7

Genetic Association Database (GAD)
SDR9C7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDR9C7
genes like me logo Genes that share disorders with SDR9C7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SDR9C7 Gene

Publications for SDR9C7 Gene

  1. SDR-O: an orphan short-chain dehydrogenase/reductase localized at mouse chromosome 10/human chromosome 12. (PMID: 12234675) Chen W. … Napoli J.L. (Gene 2002) 2 3 4 22 64
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4 64
  3. In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O). (PMID: 19703561) Kowalik D. … Moeller G. (J. Steroid Biochem. Mol. Biol. 2009) 3 4 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SDR9C7 Gene

Sources for SDR9C7 Gene

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