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Aliases for SDR42E2 Gene

Aliases for SDR42E2 Gene

  • Short Chain Dehydrogenase/Reductase Family 42E, Member 2 2 3
  • EC 1.1.1.- 4

External Ids for SDR42E2 Gene

Previous GeneCards Identifiers for SDR42E2 Gene

  • GC00U922983
  • GC16P022086

Summaries for SDR42E2 Gene

GeneCards Summary for SDR42E2 Gene

SDR42E2 (Short Chain Dehydrogenase/Reductase Family 42E, Member 2) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is SDR42E1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDR42E2 Gene

Genomics for SDR42E2 Gene

Genomic Location for SDR42E2 Gene

22,162,438 bp from pter
22,191,856 bp from pter
29,419 bases
Plus strand

Genomic View for SDR42E2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SDR42E2 Gene

No data available for Regulatory Elements for SDR42E2 Gene

Proteins for SDR42E2 Gene

  • Protein details for SDR42E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative short-chain dehydrogenase/reductase family 42E member 2
    Protein Accession:

    Protein attributes for SDR42E2 Gene

    422 amino acids
    Molecular mass:
    46869 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SDR42E2 Gene

Proteomics data for SDR42E2 Gene at MOPED

Post-translational modifications for SDR42E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDR42E2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for SDR42E2 Gene

Domains & Families for SDR42E2 Gene

Gene Families for SDR42E2 Gene

Protein Domains for SDR42E2 Gene

Suggested Antigen Peptide Sequences for SDR42E2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 3-beta-HSD family.
  • Belongs to the 3-beta-HSD family.
genes like me logo Genes that share domains with SDR42E2: view

Function for SDR42E2 Gene

Enzyme Numbers (IUBMB) for SDR42E2 Gene

Gene Ontology (GO) - Molecular Function for SDR42E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
genes like me logo Genes that share ontologies with SDR42E2: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SDR42E2 Gene

Localization for SDR42E2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SDR42E2 Gene

Pathways & Interactions for SDR42E2 Gene

SuperPathways for SDR42E2 Gene

No Data Available

Interacting Proteins for SDR42E2 Gene

Gene Ontology (GO) - Biological Process for SDR42E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SDR42E2: view

No data available for Pathways by source and SIGNOR curated interactions for SDR42E2 Gene

Drugs & Compounds for SDR42E2 Gene

No Compound Related Data Available

Transcripts for SDR42E2 Gene

mRNA/cDNA for SDR42E2 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SDR42E2 Gene

No ASD Table

Relevant External Links for SDR42E2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDR42E2 Gene

mRNA expression in normal human tissues for SDR42E2 Gene

mRNA differential expression in normal tissues according to GTEx for SDR42E2 Gene

This gene is overexpressed in Testis (x8.1), Pituitary (x5.8), Brain - Hypothalamus (x4.3), and Brain - Caudate (basal ganglia) (x4.3).
genes like me logo Genes that share expression patterns with SDR42E2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SDR42E2 Gene

Orthologs for SDR42E2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDR42E2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SDR42E2 36
  • 86 (a)
(Monodelphis domestica)
Mammalia SDR42E2 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia SDR42E2 36
  • 72 (a)
(Pan troglodytes)
Mammalia SDR42E2 36
  • 98 (a)
(Gallus gallus)
Aves -- 36
  • 62 (a)
SDR42E2 36
  • 51 (a)
(Anolis carolinensis)
Reptilia SDR42E2 36
  • 47 (a)
(Danio rerio)
Actinopterygii sdr42e2 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea hsd-1 36
  • 24 (a)
hsd-2 36
  • 29 (a)
hsd-3 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG26 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9296 36
  • 41 (a)
Species with no ortholog for SDR42E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SDR42E2 Gene

Gene Tree for SDR42E2 (if available)
Gene Tree for SDR42E2 (if available)

Paralogs for SDR42E2 Gene

Paralogs for SDR42E2 Gene

(3) SIMAP similar genes for SDR42E2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SDR42E2: view

Variants for SDR42E2 Gene

Sequence variations from dbSNP and Humsavar for SDR42E2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs715462 -- 22,189,315(+) GGAGA(A/G)CATCT intron-variant
rs889371 -- 22,160,524(+) ccaag(A/G)tttaa upstream-variant-2KB
rs889404 -- 22,161,047(-) AAAAA(A/T)TACAA upstream-variant-2KB
rs929837 -- 22,161,287(+) ACAGG(A/G)AGAGT upstream-variant-2KB
rs929838 -- 22,161,310(+) AGAAG(C/G)AAGGA upstream-variant-2KB

Variation tolerance for SDR42E2 Gene

Gene Damage Index Score: 7.56; 82.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDR42E2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SDR42E2 Gene

Disorders for SDR42E2 Gene

genes like me logo Genes that share disorders with SDR42E2: view

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SDR42E2 Gene

Publications for SDR42E2 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 67
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 67

Products for SDR42E2 Gene

Sources for SDR42E2 Gene

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