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Aliases for SDR42E2 Gene

Aliases for SDR42E2 Gene

  • Short Chain Dehydrogenase/Reductase Family 42E, Member 2 2 3 5
  • EC 1.1.1.- 4

External Ids for SDR42E2 Gene

Previous GeneCards Identifiers for SDR42E2 Gene

  • GC00U922983
  • GC16P022086

Summaries for SDR42E2 Gene

GeneCards Summary for SDR42E2 Gene

SDR42E2 (Short Chain Dehydrogenase/Reductase Family 42E, Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is SDR42E1.

Additional gene information for SDR42E2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDR42E2 Gene

Genomics for SDR42E2 Gene

GeneHancer (GH) Regulatory Elements for SDR42E2 Gene

Promoters and enhancers for SDR42E2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I022162 Enhancer 0.6 Ensembl 550.8 +0.1 97 0.8 BCOR ZNF282 MAZ SP3 ZNF140 SP2 SP1 POLR2A EZH2 SDR42E2 NPIPB4 NPIPB5 MFSD13B NPIPB3 RRN3P1 ENSG00000260905 ENSG00000260306 ENSG00000260635 GC16P022190
GH16I022099 Enhancer 1 Ensembl ENCODE 11.7 -63.3 -63303 0.3 ELF3 PKNOX1 RB1 ARID4B RAD21 RFX5 ZNF121 ARID2 ZNF143 KLF11 SDR42E2 PDZD9 GC16P022106 PIR50524 LOC105371129 VWA3A
GH16I022024 Enhancer 1 Ensembl ENCODE 11.1 -135.7 -135703 4.3 FOXA2 INSM2 RARA ZNF121 SCRT2 FOS IKZF2 RUNX3 SP5 JUNB PDZD9 SDR42E2 VWA3A C16orf52 RRN3P1 ENSG00000260306 NPIPB3 NPIPB4 NPIPB5 GC16P022022
GH16I022077 Enhancer 0.7 ENCODE 11.7 -84.6 -84553 0.2 SMARCA5 CTCF ZNF654 RB1 ZNF511 SOX6 TRIM22 REST RAD21 TGIF2 GC16P022079 PDZD9 SDR42E2 GC16P022057 C16orf52
GH16I022029 Enhancer 0.7 ENCODE 11.4 -132.5 -132508 1.6 ELF3 SOX13 FOXA2 ZNF792 CEBPG KMT2B TEAD3 NR2F6 CREM HOMEZ PDZD9 SDR42E2 VWA3A GC16P022032 GC16P022022 C16orf52
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SDR42E2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SDR42E2 Gene

Genomic Locations for SDR42E2 Gene
chr16:22,162,438-22,191,856
(GRCh38/hg38)
Size:
29,419 bases
Orientation:
Plus strand
chr16:22,177,618-22,203,075
(GRCh37/hg19)

Genomic View for SDR42E2 Gene

Genes around SDR42E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDR42E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDR42E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDR42E2 Gene

Proteins for SDR42E2 Gene

  • Protein details for SDR42E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKP2-D42E2_HUMAN
    Recommended name:
    Putative short-chain dehydrogenase/reductase family 42E member 2
    Protein Accession:
    A6NKP2

    Protein attributes for SDR42E2 Gene

    Size:
    422 amino acids
    Molecular mass:
    46869 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SDR42E2 Gene

Post-translational modifications for SDR42E2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SDR42E2 Gene

Domains & Families for SDR42E2 Gene

Gene Families for SDR42E2 Gene

Protein Domains for SDR42E2 Gene

Suggested Antigen Peptide Sequences for SDR42E2 Gene

Graphical View of Domain Structure for InterPro Entry

A6NKP2

UniProtKB/Swiss-Prot:

D42E2_HUMAN :
  • Belongs to the 3-beta-HSD family.
Family:
  • Belongs to the 3-beta-HSD family.
genes like me logo Genes that share domains with SDR42E2: view

Function for SDR42E2 Gene

Enzyme Numbers (IUBMB) for SDR42E2 Gene

Phenotypes From GWAS Catalog for SDR42E2 Gene

Gene Ontology (GO) - Molecular Function for SDR42E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with SDR42E2: view

Animal Model Products

No data available for Molecular function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SDR42E2 Gene

Localization for SDR42E2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDR42E2 gene
Compartment Confidence
peroxisome 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SDR42E2 Gene

Pathways & Interactions for SDR42E2 Gene

SuperPathways for SDR42E2 Gene

No Data Available

Interacting Proteins for SDR42E2 Gene

Gene Ontology (GO) - Biological Process for SDR42E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SDR42E2: view

No data available for Pathways by source and SIGNOR curated interactions for SDR42E2 Gene

Drugs & Compounds for SDR42E2 Gene

No Compound Related Data Available

Transcripts for SDR42E2 Gene

mRNA/cDNA for SDR42E2 Gene

(12) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SDR42E2 Gene

No ASD Table

Relevant External Links for SDR42E2 Gene

GeneLoc Exon Structure for
SDR42E2
ECgene alternative splicing isoforms for
SDR42E2

Expression for SDR42E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDR42E2 Gene

mRNA differential expression in normal tissues according to GTEx for SDR42E2 Gene

This gene is overexpressed in Testis (x8.1), Pituitary (x5.8), Brain - Hypothalamus (x4.3), and Brain - Caudate (basal ganglia) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of SDR42E2 Gene:

SDR42E2
genes like me logo Genes that share expression patterns with SDR42E2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDR42E2 Gene

Orthologs for SDR42E2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SDR42E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDR42E2 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SDR42E2 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDR42E2 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDR42E2 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 62 (a)
OneToMany
SDR42E2 34
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SDR42E2 34
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sdr42e2 34
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hsd-2 34
  • 29 (a)
ManyToMany
hsd-3 34
  • 28 (a)
ManyToMany
hsd-1 34
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG26 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9296 34
  • 41 (a)
OneToMany
Species where no ortholog for SDR42E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SDR42E2 Gene

ENSEMBL:
Gene Tree for SDR42E2 (if available)
TreeFam:
Gene Tree for SDR42E2 (if available)

Paralogs for SDR42E2 Gene

Paralogs for SDR42E2 Gene

(3) SIMAP similar genes for SDR42E2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SDR42E2: view

Variants for SDR42E2 Gene

Sequence variations from dbSNP and Humsavar for SDR42E2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000076903 -- 22,164,345(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000175416 -- 22,161,429(+) T/C upstream_transcript_variant
rs1000300266 -- 22,188,939(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000637056 -- 22,169,264(+) C/G intron_variant
rs1000717056 -- 22,185,422(+) C/T genic_downstream_transcript_variant, intron_variant

Variation tolerance for SDR42E2 Gene

Gene Damage Index Score: 7.56; 82.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SDR42E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDR42E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SDR42E2 Gene

Disorders for SDR42E2 Gene

No disorders were found for SDR42E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SDR42E2 Gene

Publications for SDR42E2 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 4 58
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58

Products for SDR42E2 Gene

Sources for SDR42E2 Gene

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