Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SDR42E1 Gene

Aliases for SDR42E1 Gene

  • Short Chain Dehydrogenase/Reductase Family 42E, Member 1 2 3 5
  • EC 1.1.1.37 63
  • EC 1.1.1.- 4
  • EC 1.1.1 63
  • HSpc105 3

External Ids for SDR42E1 Gene

Previous GeneCards Identifiers for SDR42E1 Gene

  • GC16M080590
  • GC16M082031
  • GC16M067784

Summaries for SDR42E1 Gene

GeneCards Summary for SDR42E1 Gene

SDR42E1 (Short Chain Dehydrogenase/Reductase Family 42E, Member 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and 3-beta-hydroxy-delta5-steroid dehydrogenase activity. An important paralog of this gene is NSDHL.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDR42E1 Gene

Genomics for SDR42E1 Gene

Regulatory Elements for SDR42E1 Gene

Promoters for SDR42E1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SDR42E1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SDR42E1 Gene

Chromosome:
16
Start:
81,988,855 bp from pter
End:
82,011,488 bp from pter
Size:
22,634 bases
Orientation:
Minus strand

Genomic View for SDR42E1 Gene

Genes around SDR42E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDR42E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDR42E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDR42E1 Gene

Proteins for SDR42E1 Gene

  • Protein details for SDR42E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUS8-D42E1_HUMAN
    Recommended name:
    Short-chain dehydrogenase/reductase family 42E member 1
    Protein Accession:
    Q8WUS8
    Secondary Accessions:
    • B2RDS1
    • Q9P0D1

    Protein attributes for SDR42E1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44284 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW95521.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SDR42E1 Gene

Proteomics data for SDR42E1 Gene at MOPED

Post-translational modifications for SDR42E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDR42E1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SDR42E1 Gene

Gene Families for SDR42E1 Gene

Protein Domains for SDR42E1 Gene

Suggested Antigen Peptide Sequences for SDR42E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUS8

UniProtKB/Swiss-Prot:

D42E1_HUMAN :
  • Belongs to the 3-beta-HSD family.
Family:
  • Belongs to the 3-beta-HSD family.
genes like me logo Genes that share domains with SDR42E1: view

Function for SDR42E1 Gene

Enzyme Numbers (IUBMB) for SDR42E1 Gene

Phenotypes for SDR42E1 Gene

GenomeRNAi human phenotypes for SDR42E1:
genes like me logo Genes that share phenotypes with SDR42E1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDR42E1 Gene

Localization for SDR42E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDR42E1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDR42E1 Gene COMPARTMENTS Subcellular localization image for SDR42E1 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SDR42E1 Gene

Pathways & Interactions for SDR42E1 Gene

SuperPathways for SDR42E1 Gene

No Data Available

Interacting Proteins for SDR42E1 Gene

Gene Ontology (GO) - Biological Process for SDR42E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IEA --
genes like me logo Genes that share ontologies with SDR42E1: view

No data available for Pathways by source and SIGNOR curated interactions for SDR42E1 Gene

Drugs & Compounds for SDR42E1 Gene

No Compound Related Data Available

Transcripts for SDR42E1 Gene

Unigene Clusters for SDR42E1 Gene

Short chain dehydrogenase/reductase family 42E, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SDR42E1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -

Relevant External Links for SDR42E1 Gene

GeneLoc Exon Structure for
SDR42E1
ECgene alternative splicing isoforms for
SDR42E1

Expression for SDR42E1 Gene

mRNA expression in normal human tissues for SDR42E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDR42E1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.9) and Skin - Not Sun Exposed (Suprapubic) (x6.3).

SOURCE GeneReport for Unigene cluster for SDR42E1 Gene Hs.87779

genes like me logo Genes that share expression patterns with SDR42E1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SDR42E1 Gene

Orthologs for SDR42E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SDR42E1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDR42E1 35
  • 99.24 (n)
  • 98.98 (a)
SDR42E1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SDR42E1 36
  • 84 (a)
OneToOne
SDR42E1 35
  • 85.07 (n)
  • 84.73 (a)
dog
(Canis familiaris)
Mammalia SDR42E1 35
  • 88.13 (n)
  • 88.8 (a)
SDR42E1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdr42e1 16
Sdr42e1 36
  • 79 (a)
OneToOne
Sdr42e1 35
  • 78.88 (n)
  • 79.64 (a)
oppossum
(Monodelphis domestica)
Mammalia SDR42E1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDR42E1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdr42e1 35
  • 78.71 (n)
  • 80.66 (a)
chicken
(Gallus gallus)
Aves SDR42E1 36
  • 71 (a)
OneToOne
SDR42E1 35
  • 69.23 (n)
  • 71.03 (a)
lizard
(Anolis carolinensis)
Reptilia SDR42E1 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32536 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sdr42e1 35
  • 62.47 (n)
  • 60.89 (a)
zebrafish
(Danio rerio)
Actinopterygii sdr42e1 35
  • 62.65 (n)
  • 65.15 (a)
sdr42e1 36
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hsd-1 36
  • 21 (a)
ManyToMany
hsd-2 36
  • 25 (a)
ManyToMany
hsd-3 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG26 36
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G33630 35
  • 50.27 (n)
  • 45.74 (a)
rice
(Oryza sativa)
Liliopsida Os02g0715200 35
  • 52.65 (n)
  • 50.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9296 36
  • 41 (a)
OneToMany
Species with no ortholog for SDR42E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDR42E1 Gene

ENSEMBL:
Gene Tree for SDR42E1 (if available)
TreeFam:
Gene Tree for SDR42E1 (if available)

Paralogs for SDR42E1 Gene

Paralogs for SDR42E1 Gene

(2) SIMAP similar genes for SDR42E1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SDR42E1: view

Variants for SDR42E1 Gene

Sequence variations from dbSNP and Humsavar for SDR42E1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs6564956 - 82,000,830(+) GGACA(C/G)TTTCC reference, missense, utr-variant-5-prime
rs16956174 - 82,000,007(+) TTCTT(C/T)GATCA reference, missense
rs3813012 - 81,999,334(+) TGACA(C/T)CAGTT reference, missense
rs4399528 -- 82,009,597(+) tactt(A/T)cccaa intron-variant
rs3922901 -- 82,012,771(+) GCCAC(C/T)GAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDR42E1 Gene

Variant ID Type Subtype PubMed ID
nsv907012 CNV Gain 21882294
esv2660861 CNV Deletion 23128226

Variation tolerance for SDR42E1 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDR42E1 Gene

HapMap Linkage Disequilibrium report
SDR42E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDR42E1 Gene

Disorders for SDR42E1 Gene

Relevant External Links for SDR42E1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDR42E1

No disorders were found for SDR42E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDR42E1 Gene

Publications for SDR42E1 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4 67
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SDR42E1 Gene

Sources for SDR42E1 Gene

Back to Top

Content