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Aliases for SDR42E1 Gene

Aliases for SDR42E1 Gene

  • Short Chain Dehydrogenase/Reductase Family 42E, Member 1 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 42E Member 1 3
  • EC 56
  • EC 1.1.1.- 4
  • EC 1.1.1 56
  • HSpc105 3

External Ids for SDR42E1 Gene

Previous GeneCards Identifiers for SDR42E1 Gene

  • GC16M080590
  • GC16M082031
  • GC16M067784

Summaries for SDR42E1 Gene

GeneCards Summary for SDR42E1 Gene

SDR42E1 (Short Chain Dehydrogenase/Reductase Family 42E, Member 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and 3-beta-hydroxy-delta5-steroid dehydrogenase activity. An important paralog of this gene is SDR42E2.

Additional gene information for SDR42E1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDR42E1 Gene

Genomics for SDR42E1 Gene

GeneHancer (GH) Regulatory Elements for SDR42E1 Gene

Promoters and enhancers for SDR42E1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I082010 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 566.5 +0.4 404 2 GTF2F1 ESRRA SIN3A EBF1 ZBTB7B ZBTB40 E4F1 YY1 E2F1 CTBP1 SDR42E1 PIR37849
GH16I082004 Promoter 0.5 EPDnew 550.4 +7.3 7252 0.1 SDR42E1 PIR37849
GH16I082033 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 16.1 -24.4 -24365 5.1 ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA YY1 RXRA MXD4 ELF1 HSD17B2 SDR42E1 MTCYBP28
GH16I081995 Enhancer 0.8 Ensembl ENCODE 18 +14.1 14142 2.8 CTCF ATF1 TEAD1 JUN ZNF644 RAD21 FOSL1 JUND IKZF1 CREB1 PIR37849 SDR42E1 HSD17B2 PKD1L2
GH16I082138 Enhancer 1.1 FANTOM5 Ensembl ENCODE 12.8 -127.5 -127476 1.3 NCOA3 GTF2F1 CLOCK FOXA2 CTBP1 GATA3 EGR1 SMARCE1 RFX1 FOXA1 LOC105371363 MPHOSPH6 SDR42E1 MTCYBP28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SDR42E1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SDR42E1 gene promoter:

Genomic Locations for SDR42E1 Gene

Genomic Locations for SDR42E1 Gene
22,634 bases
Minus strand

Genomic View for SDR42E1 Gene

Genes around SDR42E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDR42E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDR42E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDR42E1 Gene

Proteins for SDR42E1 Gene

  • Protein details for SDR42E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Short-chain dehydrogenase/reductase family 42E member 1
    Protein Accession:
    Secondary Accessions:
    • B2RDS1
    • Q9P0D1

    Protein attributes for SDR42E1 Gene

    393 amino acids
    Molecular mass:
    44284 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAW95521.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SDR42E1 Gene

Selected DME Specific Peptides for SDR42E1 Gene


Post-translational modifications for SDR42E1 Gene

No Post-translational modifications

Other Protein References for SDR42E1 Gene

Domains & Families for SDR42E1 Gene

Gene Families for SDR42E1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SDR42E1 Gene

Suggested Antigen Peptide Sequences for SDR42E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 3-beta-HSD family.
  • Belongs to the 3-beta-HSD family.
genes like me logo Genes that share domains with SDR42E1: view

Function for SDR42E1 Gene

Enzyme Numbers (IUBMB) for SDR42E1 Gene

Gene Ontology (GO) - Molecular Function for SDR42E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with SDR42E1: view

Phenotypes for SDR42E1 Gene

genes like me logo Genes that share phenotypes with SDR42E1: view

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDR42E1 Gene

Localization for SDR42E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDR42E1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDR42E1 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SDR42E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SDR42E1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SDR42E1 Gene

Pathways & Interactions for SDR42E1 Gene

SuperPathways for SDR42E1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDR42E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SDR42E1: view

No data available for Pathways by source and SIGNOR curated interactions for SDR42E1 Gene

Drugs & Compounds for SDR42E1 Gene

No Compound Related Data Available

Transcripts for SDR42E1 Gene

Unigene Clusters for SDR42E1 Gene

Short chain dehydrogenase/reductase family 42E, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDR42E1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP3: - -

Relevant External Links for SDR42E1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDR42E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDR42E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDR42E1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.9) and Skin - Not Sun Exposed (Suprapubic) (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of SDR42E1 Gene:


SOURCE GeneReport for Unigene cluster for SDR42E1 Gene:


Evidence on tissue expression from TISSUES for SDR42E1 Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with SDR42E1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDR42E1 Gene

Orthologs for SDR42E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SDR42E1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SDR42E1 33 34
  • 99.24 (n)
(Canis familiaris)
Mammalia SDR42E1 33 34
  • 88.13 (n)
(Bos Taurus)
Mammalia SDR42E1 33 34
  • 85.07 (n)
(Mus musculus)
Mammalia Sdr42e1 33 16 34
  • 78.88 (n)
(Rattus norvegicus)
Mammalia Sdr42e1 33
  • 78.71 (n)
(Ornithorhynchus anatinus)
Mammalia SDR42E1 34
  • 75 (a)
(Monodelphis domestica)
Mammalia SDR42E1 34
  • 72 (a)
(Gallus gallus)
Aves SDR42E1 33 34
  • 69.23 (n)
(Anolis carolinensis)
Reptilia SDR42E1 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sdr42e1 33
  • 62.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32536 33
(Danio rerio)
Actinopterygii sdr42e1 33 34
  • 62.65 (n)
(Caenorhabditis elegans)
Secernentea hsd-3 34
  • 26 (a)
hsd-2 34
  • 25 (a)
hsd-1 34
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG26 34
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G33630 33
  • 50.27 (n)
(Oryza sativa)
Liliopsida Os02g0715200 33
  • 52.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9296 34
  • 41 (a)
Species where no ortholog for SDR42E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDR42E1 Gene

Gene Tree for SDR42E1 (if available)
Gene Tree for SDR42E1 (if available)

Paralogs for SDR42E1 Gene

Paralogs for SDR42E1 Gene

(2) SIMAP similar genes for SDR42E1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SDR42E1: view

Variants for SDR42E1 Gene

Sequence variations from dbSNP and Humsavar for SDR42E1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000026916 -- 82,007,463(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000086170 -- 82,003,279(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000167790 -- 82,011,140(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000552153 -- 82,006,420(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000597928 -- 81,993,257(-) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SDR42E1 Gene

Variant ID Type Subtype PubMed ID
esv2660861 CNV deletion 23128226
esv3639348 CNV loss 21293372

Variation tolerance for SDR42E1 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SDR42E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDR42E1 Gene

Disorders for SDR42E1 Gene

Additional Disease Information for SDR42E1

No disorders were found for SDR42E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDR42E1 Gene

Publications for SDR42E1 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 4 58
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L … McKnight A (Retrovirology 2011) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for SDR42E1 Gene

Sources for SDR42E1 Gene

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