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Aliases for SDR42E1 Gene

Aliases for SDR42E1 Gene

  • Short Chain Dehydrogenase/Reductase Family 42E, Member 1 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 42E Member 1 3
  • EC 1.1.1.37 61
  • EC 1.1.1.- 4
  • EC 1.1.1 61
  • HSpc105 3

External Ids for SDR42E1 Gene

Previous GeneCards Identifiers for SDR42E1 Gene

  • GC16M080590
  • GC16M082031
  • GC16M067784

Summaries for SDR42E1 Gene

GeneCards Summary for SDR42E1 Gene

SDR42E1 (Short Chain Dehydrogenase/Reductase Family 42E, Member 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and 3-beta-hydroxy-delta5-steroid dehydrogenase activity. An important paralog of this gene is SDR42E2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDR42E1 Gene

Genomics for SDR42E1 Gene

Regulatory Elements for SDR42E1 Gene

Enhancers for SDR42E1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G082033 1.4 FANTOM5 Ensembl ENCODE 16 -24.4 -24365 5.1 ELF3 HNRNPUL1 FOXA2 ATF1 ARID4B DMAP1 RAD21 YY1 RARA FOS SDR42E1 HSD17B2 MTCYBP28
GH16G081995 1.1 Ensembl ENCODE 18 +14.1 14142 2.8 ELF3 ATF1 ARID4B DMAP1 ZSCAN9 RAD21 SLC30A9 GATA2 FOS ZNF654 SDR42E1 HSD17B2 PKD1L2 PIR37849
GH16G082138 1.3 FANTOM5 Ensembl ENCODE 12.7 -127.5 -127477 1.3 GTF2F1 RFX1 ZHX2 RAD21 ATF2 ZNF592 FOXA1 MBD2 CTBP1 JUND MPHOSPH6 SDR42E1 MTCYBP28 LOC105371363
GH16G082010 0.9 ENCODE 16.4 +0.4 405 2.0 FOXA2 SIN3A ARID4B ZBTB7B ZBTB40 YY1 EGR1 ELK1 ZNF143 FOS SDR42E1 PIR37849
GH16G082069 1.2 Ensembl ENCODE dbSUPER 10.9 -59.8 -59776 2.9 MAFG YY1 JUND ZNF316 NFE2L1 NFE2 HNF4A FOS EMSY MAFK HSD17B2 SDR42E1 MTCYBP28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDR42E1 on UCSC Golden Path with GeneCards custom track

Promoters for SDR42E1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088558 188 601 SIN3A ARID4B ZBTB7B ZBTB40 YY1 EGR1 ELK1 ZNF143 THAP11 HCFC1

Genomic Location for SDR42E1 Gene

Chromosome:
16
Start:
81,988,855 bp from pter
End:
82,011,488 bp from pter
Size:
22,634 bases
Orientation:
Minus strand

Genomic View for SDR42E1 Gene

Genes around SDR42E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDR42E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDR42E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDR42E1 Gene

Proteins for SDR42E1 Gene

  • Protein details for SDR42E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUS8-D42E1_HUMAN
    Recommended name:
    Short-chain dehydrogenase/reductase family 42E member 1
    Protein Accession:
    Q8WUS8
    Secondary Accessions:
    • B2RDS1
    • Q9P0D1

    Protein attributes for SDR42E1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44284 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW95521.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SDR42E1 Gene

Selected DME Specific Peptides for SDR42E1 Gene

Q8WUS8:
  • ASYGMSGREQLN
  • DHYSRTK
  • GDESLPYLP
  • PVNNFEFFRPLVEGLGY
  • AGIYGPGEQRHLPRI
  • VEWFKAHGHGR
  • GQPYFISDG
  • VPRLVYTSTFNVIFGGQ
  • KTGVTHYF
  • LEKAKKEL

Post-translational modifications for SDR42E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SDR42E1 Gene

Domains & Families for SDR42E1 Gene

Gene Families for SDR42E1 Gene

Protein Domains for SDR42E1 Gene

Suggested Antigen Peptide Sequences for SDR42E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUS8

UniProtKB/Swiss-Prot:

D42E1_HUMAN :
  • Belongs to the 3-beta-HSD family.
Family:
  • Belongs to the 3-beta-HSD family.
genes like me logo Genes that share domains with SDR42E1: view

Function for SDR42E1 Gene

Enzyme Numbers (IUBMB) for SDR42E1 Gene

Gene Ontology (GO) - Molecular Function for SDR42E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with SDR42E1: view

Phenotypes for SDR42E1 Gene

genes like me logo Genes that share phenotypes with SDR42E1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SDR42E1 Gene

Localization for SDR42E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDR42E1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDR42E1 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SDR42E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SDR42E1: view

Pathways & Interactions for SDR42E1 Gene

SuperPathways for SDR42E1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDR42E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SDR42E1: view

No data available for Pathways by source and SIGNOR curated interactions for SDR42E1 Gene

Drugs & Compounds for SDR42E1 Gene

No Compound Related Data Available

Transcripts for SDR42E1 Gene

Unigene Clusters for SDR42E1 Gene

Short chain dehydrogenase/reductase family 42E, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDR42E1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -

Relevant External Links for SDR42E1 Gene

GeneLoc Exon Structure for
SDR42E1
ECgene alternative splicing isoforms for
SDR42E1

Expression for SDR42E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SDR42E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDR42E1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.9) and Skin - Not Sun Exposed (Suprapubic) (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of SDR42E1 Gene:

SDR42E1

SOURCE GeneReport for Unigene cluster for SDR42E1 Gene:

Hs.87779

Evidence on tissue expression from TISSUES for SDR42E1 Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with SDR42E1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SDR42E1 Gene

Orthologs for SDR42E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SDR42E1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDR42E1 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia SDR42E1 34 35
  • 88.13 (n)
cow
(Bos Taurus)
Mammalia SDR42E1 34 35
  • 85.07 (n)
mouse
(Mus musculus)
Mammalia Sdr42e1 34 16 35
  • 78.88 (n)
rat
(Rattus norvegicus)
Mammalia Sdr42e1 34
  • 78.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SDR42E1 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDR42E1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDR42E1 34 35
  • 69.23 (n)
lizard
(Anolis carolinensis)
Reptilia SDR42E1 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdr42e1 34
  • 62.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32536 34
zebrafish
(Danio rerio)
Actinopterygii sdr42e1 34 35
  • 62.65 (n)
worm
(Caenorhabditis elegans)
Secernentea hsd-3 35
  • 26 (a)
ManyToMany
hsd-2 35
  • 25 (a)
ManyToMany
hsd-1 35
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG26 35
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G33630 34
  • 50.27 (n)
rice
(Oryza sativa)
Liliopsida Os02g0715200 34
  • 52.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9296 35
  • 41 (a)
OneToMany
Species where no ortholog for SDR42E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDR42E1 Gene

ENSEMBL:
Gene Tree for SDR42E1 (if available)
TreeFam:
Gene Tree for SDR42E1 (if available)

Paralogs for SDR42E1 Gene

Paralogs for SDR42E1 Gene

(2) SIMAP similar genes for SDR42E1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SDR42E1: view

Variants for SDR42E1 Gene

Sequence variations from dbSNP and Humsavar for SDR42E1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000026916 -- 82,007,463(+) ATTTT(A/G)CAGGT intron-variant
rs1000086170 -- 82,003,279(+) CCTAA(C/G)AGTGA intron-variant
rs1000167790 -- 82,011,140(+) ATGTC(C/T)TTAAA intron-variant
rs1000552153 -- 82,006,420(+) GGAAG(G/T)CAAAA intron-variant
rs1000597928 -- 81,993,257(+) CCTCT(A/C)AGCAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SDR42E1 Gene

Variant ID Type Subtype PubMed ID
esv2660861 CNV deletion 23128226
esv3639348 CNV loss 21293372

Variation tolerance for SDR42E1 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDR42E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDR42E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDR42E1 Gene

Disorders for SDR42E1 Gene

Relevant External Links for SDR42E1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDR42E1

No disorders were found for SDR42E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDR42E1 Gene

Publications for SDR42E1 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4 64
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3 64
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for SDR42E1 Gene

Sources for SDR42E1 Gene

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