SDR39U1 Gene
protein-coding GIFtS : 44
GCID: GC14 M024908
short chain dehydrogenase/reductase family 39U, member 1 (Previous name: chromosome 14 open reading frame 124 ) (Previous symbol: C14orf124 )
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Aliasesfor SDR39U1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Short Chain Dehydrogenase/Reductase Family 39U, Member 1 1 2 Chromosome 14 Open Reading Frame 1241 C14orf1241 2 3 Epimerase Family Protein SDR39U12 HCDI1 2 3 EC 1.1.1.-3 Short-Chain Dehydrogenase/Reductase Family 39U Member 12 3
Export aliases for SDR39U1 gene to outside databases Previous GC identifers: GC14M023979 GC14M005023
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Summariesfor SDR39U1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: D39U1_HUMAN, Q9NRG7 Function : Putative NADP-dependent oxidoreductase
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Genomic Viewsfor SDR39U1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SDR39U1 gene promoter: Max1 AML1a MAZR Tal-1 POU3F1 E47 PPAR-gamma1 PPAR-gamma2 ATF6 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for SDR39U1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SDR39U1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q12 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q12 SDR39U1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M024908: view genomic region
(about GC identifiers )
Start:
24,908,972 bp from pter
End:
24,912,111 bp from pter
Size:
3,140 bases
Orientation:
minus strand
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Proteinsfor SDR39U1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: D39U1_HUMAN, Q9NRG7 (See
protein sequence )Recommended Name: Epimerase family protein SDR39U1 Size : 319 amino acids; 34748 Da
Miscellaneous : Despite its name, it shares more sequence similarity with the sugar epimerase family than with theshort-chain dehydrogenases/reductases (SDR) family
1 PDB 3D structure from and Proteopedia for SDR39U1 :4B4O (3D)
 
Secondary accessions : Q6ZW71 Q9BVQ3Alternative splicing : 3 isoforms : Q9NRG7-1 Q9NRG7-2 Q9NRG7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SDR39U1: NX_Q9NRG7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NRG7 SDR39U1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_064580.2 ENSEMBL proteins: ENSP00000382327 ENSP00000452499 ENSP00000446077 ENSP00000452438 ENSP00000451903 ENSP00000452076 ENSP00000450915 ENSP00000451593 ENSP00000450946 ENSP00000451275 ENSP00000382322 Human Recombinant Protein Products: SDR39U1 Antibody Products: Assay Products for SDR39U1:
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Protein
Domains / Familiesfor SDR39U1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SDR39U1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NRG7 ProtoNet protein and cluster: Q9NRG7
UniProtKB/Swiss-Prot: D39U1_HUMAN, Q9NRG7 Similarity : Belongs to the sugar epimerase family. SDR39U1 subfamily
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Functionfor SDR39U1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: D39U1_HUMAN, Q9NRG7 Function : Putative NADP-dependent oxidoreductaseEnzyme Number (IUBMB): EC 1.1.1.- 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SDR39U1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SDR39U1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SDR39U1 (NM_020195 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDR39U1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SDR39U1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR39U1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding
IEA -- GO:0016491 oxidoreductase activity
IEA --
SDR39U1 for ontologies About GeneDecksing 5 GenomeRNAi human phenotypes for SDR39U1 :
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Pathways & Interactionsfor SDR39U1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDR39U1 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)4 Interacting proteins for SDR39U1 (Q9NRG7 3 ENSP00000382327 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor SDR39U1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SDR39U1 Search CenterWatch for drugs/clinical trials and news about SDR39U1 / D39U1
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Transcriptsfor SDR39U1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SDR39U1 gene: NM_020195.2 Unigene Cluster for SDR39U1:
Short chain dehydrogenase/reductase family 39U, member 1 Hs.643552 [show with all ESTs ] Unigene Representative Sequence: AF226050 18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22 ): ENST00000544691 ENST00000399395 (uc001wpm.3 ) ENST00000556548 (uc001wpi.3 )ENST00000553930 ENST00000556262 ENST00000538105 ENST00000554698 ENST00000556707 ENST00000555365 ENST00000553546 ENST00000555561 ENST00000553343 ENST00000554947 ENST00000556249 ENST00000555225 ENST00000555355 ENST00000556523 ENST00000555830 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SDR39U1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SDR39U1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SDR39U1 (NM_020195 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDR39U1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SDR39U1
Additional cDNA sequence: AF226050.1 BC000989.2 BC008566.1 BX161384.1
21 DOTS entries : DT.100876010 DT.91899229
DT.75174154 DT.100858216 DT.100651003 DT.100642885 DT.120753170 DT.97855215 DT.100863684 DT.97855214 DT.319218 DT.92476524 DT.95326681 DT.95326700 DT.91940952 DT.100650997 DT.100651693 DT.100764222 DT.100871549 DT.100873406 DT.95326751 24/337 AceView cDNA sequences (see all 337 ):
CR600486 BU734567 BU782816 CR615168 BF437685 CR623352 CR602789 BM704976 AI569601 CR590864 AA321535 BU781910 BX161384 CR608148 BU071253 BU729730 BU625116 BM704192 CR610185 CR616064 AK123513 CR592384 CR601098 T32715 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SDR39U1 (see all 14 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i SP1 :           -     -   -   -     -   -   -                       SP2 :           -     -   -   -     -   -   -                       SP3 :           -     -   -   -     -   -   -                       SP4 :           -     -   -   -   -   -   -   -                       SP5 :           -         -   -   -   -   -                      
ECgene alternative splicing isoforms for SDR39U1
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Expression for SDR39U1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SDR39U1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCCTGCAGCT
About this image SDR39U1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SDR39U1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SDR39U1 SOURCE GeneReport for Unigene cluster: Hs.643552 UniProtKB/Swiss-Prot: D39U1_HUMAN, Q9NRG7 Tissue specificity : Expressed in adrenal gland SABiosciences Custom PCR Arrays for SDR39U1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SDR39U1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SDR39U1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SDR39U1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SDR39U1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR39U1
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Orthologsfor SDR39U1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SDR39U1 gene from 7/22 species (see all 22 ) About this table
ENSEMBL Gene Tree for SDR39U1 (if available)TreeFam Gene Tree for SDR39U1 (if available)
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Paralogsfor SDR39U1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor SDR39U1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SDR39U1 (24908972 - 24912111 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SDR39U1: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor SDR39U1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SDR39U1 for disorders About GeneDecksing 2 diseases for SDR39U1 : About MalaCards tuberculosis mycobacterium tuberculosis Export disorders for SDR39U1 gene to outside databases
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Publicationsfor SDR39U1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SDR39U1 gene integrated from 9 sources : (articles sorted by number of sources associating them with SDR39U1) Utopia : connect your pdf to the dynamic world of online information
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726) 1 , 2 , 3 Persson B.... Oppermann U. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 2 Heilig R.... Weissenbach J. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for SDR39U1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SDR39U1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SDR39U1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SDR39U1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SDR39U1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SDR39U1 gene: Search GeneIP for patents involving SDR39U1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SDR39U1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SDR39U1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SDR39U1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SDR39U1 OriGene Protein Over-expression Lysate for SDR39U1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SDR39U1 OriGene 3'-UTR Clone for SDR39U1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SDR39U1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SDR39U1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SDR39U1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SDR39U1 OriGene Custom Protein Services for SDR39U1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDR39U1 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDR39U1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SDR39U1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SDR39U1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SDR39U1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SDR39U1
Search Tocris compounds for SDR39U1
SDR39U1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR39U1
Search ThermoFisher Antibodies for SDR39U1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SDR39U1
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Aliases for SDR39U1
Databases for SDR39U1
Disorders / Diseases for SDR39U1
Domains / Families for SDR39U1
Drugs / Compounds for SDR39U1
Expression for SDR39U1
Function for SDR39U1
Genomic Views for SDR39U1
Intellectual Property for SDR39U1
Orthologs for SDR39U1
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Pathways / Interactions for SDR39U1
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Proteins for SDR39U1
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