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Aliases for SDR39U1 Gene

Aliases for SDR39U1 Gene

  • Short Chain Dehydrogenase/Reductase Family 39U, Member 1 2 3
  • C14orf124 3 4
  • HCDI 3 4
  • Short-Chain Dehydrogenase/Reductase Family 39U Member 1 4
  • Chromosome 14 Open Reading Frame 124 2
  • Epimerase Family Protein SDR39U1 3
  • EC 1.1.1.- 4

External Ids for SDR39U1 Gene

Previous HGNC Symbols for SDR39U1 Gene

  • C14orf124

Previous GeneCards Identifiers for SDR39U1 Gene

  • GC14M023979
  • GC14M024908
  • GC14M005023

Summaries for SDR39U1 Gene

Entrez Gene Summary for SDR39U1 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) superfamily, which includes both classical and extended types. The encoded protein represents an extended type, with similarity to epimerases. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for SDR39U1 Gene

SDR39U1 (Short Chain Dehydrogenase/Reductase Family 39U, Member 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for SDR39U1 Gene

  • Putative NADP-dependent oxidoreductase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDR39U1 Gene

Genomics for SDR39U1 Gene

Regulatory Elements for SDR39U1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SDR39U1 Gene

Start:
24,439,766 bp from pter
End:
24,442,905 bp from pter
Size:
3,140 bases
Orientation:
Minus strand

Genomic View for SDR39U1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDR39U1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDR39U1 Gene

Proteins for SDR39U1 Gene

  • Protein details for SDR39U1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRG7-D39U1_HUMAN
    Recommended name:
    Epimerase family protein SDR39U1
    Protein Accession:
    Q9NRG7
    Secondary Accessions:
    • Q6ZW71
    • Q9BVQ3

    Protein attributes for SDR39U1 Gene

    Size:
    319 amino acids
    Molecular mass:
    34748 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Despite its name, it shares more sequence similarity with the sugar epimerase family than with the short-chain dehydrogenases/reductases (SDR) family

    Three dimensional structures from OCA and Proteopedia for SDR39U1 Gene

    Alternative splice isoforms for SDR39U1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDR39U1 Gene

Proteomics data for SDR39U1 Gene at MOPED

Post-translational modifications for SDR39U1 Gene

  • Ubiquitination at Lys102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SDR39U1 Gene

Domains for SDR39U1 Gene

Gene Families for SDR39U1 Gene

HGNC:
  • SDRA :Short chain dehydrogenase/reductase superfamily / Atypical members

Protein Domains for SDR39U1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SDR39U1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRG7

UniProtKB/Swiss-Prot:

D39U1_HUMAN :
  • Q9NRG7
Family:
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
genes like me logo Genes that share domains with SDR39U1: view

Function for SDR39U1 Gene

Molecular function for SDR39U1 Gene

UniProtKB/Swiss-Prot Function:
Putative NADP-dependent oxidoreductase.

Enzyme Numbers (IUBMB) for SDR39U1 Gene

Gene Ontology (GO) - Molecular Function for SDR39U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016491 oxidoreductase activity IEA --
GO:0050662 coenzyme binding --
genes like me logo Genes that share ontologies with SDR39U1: view
genes like me logo Genes that share phenotypes with SDR39U1: view

Animal Model Products

CRISPR Products

miRNA for SDR39U1 Gene

miRTarBase miRNAs that target SDR39U1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDR39U1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SDR39U1 Gene

Localization for SDR39U1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDR39U1 Gene COMPARTMENTS Subcellular localization image for SDR39U1 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SDR39U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with SDR39U1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SDR39U1 Gene

Pathways for SDR39U1 Gene

SuperPathways for SDR39U1 Gene

No Data Available

Interacting Proteins for SDR39U1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000382327%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000382327 Q9NRG7-D39U1_HUMAN for SDR39U1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SDR39U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SDR39U1: view

No data available for Pathways by source for SDR39U1 Gene

Transcripts for SDR39U1 Gene

Unigene Clusters for SDR39U1 Gene

Short chain dehydrogenase/reductase family 39U, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDR39U1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDR39U1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: -
SP10: - - - - - - - - -
SP11: - - -
SP12: - - -
SP13:
SP14: -

Relevant External Links for SDR39U1 Gene

GeneLoc Exon Structure for
SDR39U1
ECgene alternative splicing isoforms for
SDR39U1

Expression for SDR39U1 Gene

mRNA expression in normal human tissues for SDR39U1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SDR39U1 Gene

This gene is overexpressed in Brain (14.3) and Adrenal (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDR39U1 Gene

SOURCE GeneReport for Unigene cluster for SDR39U1 Gene Hs.643552

mRNA Expression by UniProt/SwissProt for SDR39U1 Gene

Q9NRG7-D39U1_HUMAN
Tissue specificity: Expressed in adrenal gland
genes like me logo Genes that share expressions with SDR39U1: view

Expression partners for SDR39U1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SDR39U1 Gene

Orthologs for SDR39U1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SDR39U1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SDR39U1 35
  • 88.96 (n)
  • 88.05 (a)
SDR39U1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SDR39U1 35
  • 89.87 (n)
  • 88.05 (a)
SDR39U1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdr39u1 35
  • 85.5 (n)
  • 84.93 (a)
Sdr39u1 16
Sdr39u1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SDR39U1 35
  • 99.43 (n)
  • 99.32 (a)
SDR39U1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdr39u1 35
  • 86.06 (n)
  • 86.06 (a)
oppossum
(Monodelphis domestica)
Mammalia SDR39U1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDR39U1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sdr39u1 35
  • 59.93 (n)
  • 59.93 (a)
zebrafish
(Danio rerio)
Actinopterygii sdr39u1 35
  • 59.05 (n)
  • 55.71 (a)
sdr39u1 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000649 35
  • 53.94 (n)
  • 50.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8768 35
  • 49.42 (n)
  • 42.66 (a)
CG8768 36
  • 40 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SULA 35
  • 48.94 (n)
  • 39.44 (a)
rice
(Oryza sativa)
Liliopsida Os02g0834700 35
  • 47.81 (n)
  • 37.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5445 36
  • 47 (a)
OneToOne
Species with no ortholog for SDR39U1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDR39U1 Gene

ENSEMBL:
Gene Tree for SDR39U1 (if available)
TreeFam:
Gene Tree for SDR39U1 (if available)

Paralogs for SDR39U1 Gene

No data available for Paralogs for SDR39U1 Gene

Variants for SDR39U1 Gene

Sequence variations from dbSNP and Humsavar for SDR39U1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_057465 -
VAR_057466 -
VAR_060623 -
VAR_060624 -

Structural Variations from Database of Genomic Variants (DGV) for SDR39U1 Gene

Variant ID Type Subtype PubMed ID
nsv482171 CNV Loss 20164927

Relevant External Links for SDR39U1 Gene

HapMap Linkage Disequilibrium report
SDR39U1
Human Gene Mutation Database (HGMD)
SDR39U1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDR39U1 Gene

Disorders for SDR39U1 Gene

No disorders were found for SDR39U1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SDR39U1 Gene

Publications for SDR39U1 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for SDR39U1 Gene

Sources for SDR39U1 Gene

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