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SDR16C5 Gene

protein-coding   GIFtS: 53
GCID: GC08M057212

Short Chain Dehydrogenase/Reductase Family 16C, Member 5

  Search for SDR16C5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Short Chain Dehydrogenase/Reductase Family 16C, Member 51 2     retSDR22 3
RDHE22 3 5     RDH#22
Retinal Short-Chain Dehydrogenase Reductase 22 3     Epidermal Retinal Dehydrogenase 22
Short-Chain Dehydrogenase/Reductase Family 16C Member 52 3     Epidermal Retinol Dehydrogenase 22
EPHD-22 3     Retinal Short Chain Dehydrogenase Reductase2
RDH-E22 3     EC 1.1.1.1053

External Ids:    HGNC: 303111   Entrez Gene: 1958142   Ensembl: ENSG000001707867   OMIM: 6089895   UniProtKB: Q8N3Y73   

Export aliases for SDR16C5 gene to outside databases

Previous GC identifers: GC08M057376 GC08M052679


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SDR16C5 Gene:
RDHE2 belongs to a family of short-chain alcohol dehydrogenases/reductases that catalyze the first and
rate-limiting step that generates retinaldehyde from retinol (Matsuzaka et al., 2002 (PubMed 12372410)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for SDR16C5 Gene:
SDR16C5 (short chain dehydrogenase/reductase family 16C, member 5) is a protein-coding gene. GO annotations related to this gene include retinol dehydrogenase activity. An important paralog of this gene is HSD17B13.

UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7
Function: Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions.
Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or
11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SDR16C5 gene promoter:
         c-Fos   AP-1   FOXF2   JunB   Fra-1   FosB   JunD   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDR16C5 promoter sequence
   Search Chromatin IP Primers for SDR16C5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDR16C5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.1   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.1

SDR16C5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDR16C5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M057212:  view genomic region     (about GC identifiers)

Start:
57,212,569 bp from pter      End:
57,233,335 bp from pter
Size:
20,767 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7 (See protein sequence)
Recommended Name: Epidermal retinol dehydrogenase 2  
Size: 309 amino acids; 34095 Da
Sequence caution: Sequence=BAB71545.1; Type=Frameshift; Positions=226;
Secondary accessions: B4DGK2 Q330K3 Q8TDV9 Q96LX1
Alternative splicing: 2 isoforms:  Q8N3Y7-1   Q8N3Y7-2   

Explore the universe of human proteins at neXtProt for SDR16C5: NX_Q8N3Y7

Explore proteomics data for SDR16C5 at MOPED


See SDR16C5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_620419.2  
ENSEMBL proteins: 
 ENSP00000379947   ENSP00000307607   ENSP00000431010  

SDR16C5 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

3 InterPro protein domains:
 IPR002347 Glc/ribitol_DH
 IPR002198 DH_sc/Rdtase_SDR
 IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q8N3Y7

ProtoNet protein and cluster: Q8N3Y7

2 Blocks protein domains:
IPB002198 Short-chain dehydrogenase/reductase SDR
IPB002347 Glucose/ribitol dehydrogenase family signature


UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


Find genes that share domains with SDR16C5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RDHE2_HUMAN, Q8N3Y7
Function: Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions.
Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or
11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH
Catalytic activity: All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) =
all-trans-retinal-[cellular-retinol-binding-protein] + NADH

     Enzyme Number (IUBMB): EC 1.1.1.1051

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004745retinol dehydrogenase activity IDA18926804
GO:0016491oxidoreductase activity ----
     
Find genes that share ontologies with SDR16C5           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDR16C5
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miRNA
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miRTarBase miRNAs that target SDR16C5:
hsa-mir-335-5p (MIRT018359)

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6 qRT-PCR Assays for microRNAs that regulate SDR16C5:
hsa-miR-515-5p hsa-miR-3140-3p hsa-miR-548g hsa-miR-3143 hsa-miR-330-3p hsa-miR-519e*
SwitchGear 3'UTR luciferase reporter plasmidSDR16C5 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SDR16C5

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RDHE2_HUMAN, Q8N3Y7: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
extracellular2
golgi apparatus1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IDA18926804
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with SDR16C5           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SDR16C5 About    
See pathways by source

SuperPathContained pathways About
1Chemical carcinogenesis
Retinol metabolism0.35
2retinoate biosynthesis I
retinoate biosynthesis I


Find genes that share SuperPaths with SDR16C5           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for SDR16C5
    retinoate biosynthesis I


1 Kegg Pathway  (Kegg details for SDR16C5):
    Retinol metabolism

UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7
Pathway: Cofactor metabolism; retinol metabolism

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SDR16C5
Interactions:

    Search GeneGlobe Interaction Network for SDR16C5

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for SDR16C5 (ENSP000003076074) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

InteractantInteraction Details
GeneCardExternal ID(s)
ALDH1A3ENSP000003322564STRING: ENSP00000332256
TTPALENSP000002626054STRING: ENSP00000262605
EXTL1ENSP000003633984STRING: ENSP00000363398
NLKENSP000003846254STRING: ENSP00000384625
ALDH1A1ENSP000002977854STRING: ENSP00000297785
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008152metabolic process ----
GO:0042572retinol metabolic process IEA--
GO:0042574retinal metabolic process IDA18926804
GO:0043616keratinocyte proliferation IMP12372410
GO:0050908detection of light stimulus involved in visual perception NAS12407145

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SDR16C5 (RDHE2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SDR16C5 gene: 
NM_138969.2  

Unigene Cluster for SDR16C5:

Short chain dehydrogenase/reductase family 16C, member 5
Hs.170673  [show with all ESTs]
Unigene Representative Sequence: NM_138969
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000396721(uc003xsy.1 uc010lyk.1 uc010lyl.1) ENST00000303749
ENST00000522671
miRNA
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6 qRT-PCR Assays for microRNAs that regulate SDR16C5:
hsa-miR-515-5p hsa-miR-3140-3p hsa-miR-548g hsa-miR-3143 hsa-miR-330-3p hsa-miR-519e*
SwitchGear 3'UTR luciferase reporter plasmidSDR16C5 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SDR16C5
Predesigned siRNA for gene silencing in human, mouse, rat SDR16C5
Clone
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GenScript: all cDNA clones in your preferred vector: SDR16C5 (NM_138969)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDR16C5
Primer
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  QuantiTect SYBR Green Assays in human, mouse, rat SDR16C5
  QuantiFast Probe-based Assays in human, mouse, rat SDR16C5

Additional mRNA sequence: 

AB083038.1 AK057667.1 AK095159.1 AK294634.1 AY444559.1 BC037219.1 BC064525.1 

3 DOTS entries:

DT.436976  DT.100019872  DT.91821182 

Selected AceView cDNA sequences (see all 46):

BM980982 AA295728 BM921464 BM766000 AK057667 BM126305 BC064525 BE222471 
NM_138969 AI340037 BC037219 CK904612 CK904613 AA507036 AW050789 AK095159 
AI692444 BM982104 AB083038 BM054750 CD701414 BG542111 BX118293 AI150649 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SDR16C5    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:                                                                  
SP2:                                                  -               
SP3:                          -                       -               


ECgene alternative splicing isoforms for SDR16C5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SDR16C5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAATGGATGG
SDR16C5 Expression
About this image


SDR16C5 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Bone (Muscoskeletal System)
         Zeugopod Growth Plate
SDR16C5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SDR16C5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.170673

UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7
Tissue specificity: Detected in adult lung. Detected at low levels in adult brain, heart, testis, placenta,
cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin
keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients.
Detected in fetal kidney, skin and lung

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR16C5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SDR16C5 gene from Selected species (see all 19)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sdr16c51 , 5 short chain dehydrogenase/reductase family 16C, member more1, 5 82.36(n)1
80.19(a)1
  4 (2.23 cM)5
2422851  NM_181989.11  NP_871789.11 
 39959365 
chicken
(Gallus gallus)
Aves SDR16C51 short chain dehydrogenase/reductase family 16C, member more 64.55(n)
60.87(a)
  421130  NM_001031022.1  NP_001026193.1 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 5)
Uncharacterized protein
(see all 5)
52(a)
49(a)
(see all 5)
1 ↔ many
1 ↔ many
(see all 5)
GL343244.1(28297-47817)
GL343656.1(226706-235688)
African clawed frog
(Xenopus laevis)
Amphibia Xl.294442 Xenopus laevis transcribed sequence with weak similarity more 75.39(n)    BX846538.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.264312 Danio rerio cDNA clone MGC63829 IMAGE3816610, complete more 79.36(n)    BC054138.1 
fruit fly
(Drosophila melanogaster)
Insecta CG92651 CG9265 52.92(n)
45.14(a)
  35369  NM_001273726.1  NP_001260655.1 
worm
(Caenorhabditis elegans)
Secernentea dhs-191 dhs-19 58.39(n)
52.55(a)
  179578  NM_073514.5  NP_505915.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes --
TDA56
Putative protein of unknown function with similari...
Putative protein of unknown function; detected in ...
24(a)
21(a)
many ↔ many
many ↔ many
IV(255604-256530) YDL114W
XII(987062-988113) YLR426W


ENSEMBL Gene Tree for SDR16C5 (if available)
TreeFam Gene Tree for SDR16C5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SDR16C5 gene
HSD17B132  RDH102  HSD17B112  DHRS32  
4 SIMAP similar genes for SDR16C5 using alignment to 2 protein entries:     RDHE2_HUMAN (see all proteins):
HSD17B13    RDH10    DHRS3    HSD17B11

Find genes that share paralogs with SDR16C5           About GenesLikeMe


1 Pseudogenes.org Pseudogene for SDR16C5
PGOHUM00000258343


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SDR16C5 (see all 424)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3732847101,2
C--57222853(+) GAGGA-/AGGAGGAG 1 -- int10--------
rs1999950111,2
C--57222894(+) GGAGGA/GGGAAG 1 -- int10--------
rs582764861,2
C--57223290(+) AAAAA-/GAAAAAGA 2 -- int1 cds11Minor allele frequency- GAA:0.00NA 2
rs1131968391,2
C--57223290(+) AAAAAA/GAAAAA 1 -- int12Minor allele frequency- G:0.00WA CSA 3
rs358698301,2
C--57225337(+) CCAAG-/TT/TTT
        
TTTTT
1 -- int12NA 4
rs1400219671,2
--57309880(+) GAAACA/GGGCAT 1 -- int10--------
rs1859687471,2
C--57309883(+) ACGGGC/TATGAC 1 -- int10--------
rs1895246591,2
--57309961(+) ATCCAC/TTAATT 1 -- int10--------
rs1498452201,2
--57310174(+) TCCCCA/GAAGAG 1 -- int10--------
rs1817988431,2
--57310356(+) GTGGAA/GTAAGA 1 -- int10--------

HapMap Linkage Disequilibrium report for SDR16C5 (57212569 - 57233335 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for SDR16C5:    About this table    
Variant IDTypeSubtypePubMed ID
esv2737024CNV Deletion23290073

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SDR16C5
DNA2.0 Custom Variant and Variant Library Synthesis for SDR16C5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608989    OMIM disorders: --


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Human Genome Epidemiology (HuGE) Navigator: SDR16C5 (0 documents)

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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SDR16C5 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with SDR16C5)
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  1. Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. (PubMed id 12372410)1, 2, 3, 9 Matsuzaka Y....Inoko H. (Biochem. Biophys. Res. Commun. 2002)
  2. Biochemical characterization of human epidermal retinol dehydrogenase 2. (PubMed id 18926804)1, 2, 9 Lee S.-A.... Kedishvili N.Y. (Chem. Biol. Interact. 2009)
  3. hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis. (PubMed id 15457346)1, 2 Matsuzaka Y.... Inoko H. (Mamm. Genome 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
  6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
  8. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
  9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  10. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (Nature 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 195814 HGNC: 30311 AceView: RDH-E2 Ensembl:ENSG00000170786 euGenes: HUgn195814
ECgene: SDR16C5 Kegg: 195814 H-InvDB: SDR16C5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SDR16C5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SDR16C5 gene:
Search GeneIP for patents involving SDR16C5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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