Aliases for SDR16C5 Gene
External Ids for SDR16C5 Gene
Previous GeneCards Identifiers for SDR16C5 Gene
RDHE2 belongs to a family of short-chain alcohol dehydrogenases/reductases that catalyze the first and rate-limiting step that generates retinaldehyde from retinol (Matsuzaka et al., 2002 [PubMed 12372410]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SDR16C5 Gene
SDR16C5 (Short Chain Dehydrogenase/Reductase Family 16C, Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and retinoate biosynthesis I. GO annotations related to this gene include oxidoreductase activity and retinol dehydrogenase activity. An important paralog of this gene is RDH10.
UniProtKB/Swiss-Prot for SDR16C5 Gene
Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.