Aliases for SDR16C5 Gene
External Ids for SDR16C5 Gene
RDHE2 belongs to a family of short-chain alcohol dehydrogenases/reductases that catalyze the first and rate-limiting step that generates retinaldehyde from retinol (Matsuzaka et al., 2002 [PubMed 12372410]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SDR16C5 Gene
SDR16C5 (Short Chain Dehydrogenase/Reductase Family 16C, Member 5) is a Protein Coding gene. Among its related pathways are retinoate biosynthesis I and Chemical carcinogenesis. GO annotations related to this gene include retinol dehydrogenase activity. An important paralog of this gene is RDH10.
UniProtKB/Swiss-Prot for SDR16C5 Gene
Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.