Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SDR16C5 Gene

protein-coding   GIFtS: 53
GCID: GC08M057212

Short Chain Dehydrogenase/Reductase Family 16C, Member 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Short Chain Dehydrogenase/Reductase Family 16C, Member 51 2     retSDR22 3
RDHE22 3 5     RDH#22
Retinal Short-Chain Dehydrogenase Reductase 22 3     Epidermal Retinal Dehydrogenase 22
Short-Chain Dehydrogenase/Reductase Family 16C Member 52 3     Epidermal Retinol Dehydrogenase 22
EPHD-22 3     Retinal Short Chain Dehydrogenase Reductase2
RDH-E22 3     EC 1.1.1.1053

External Ids:    HGNC: 303111   Entrez Gene: 1958142   Ensembl: ENSG000001707867   OMIM: 6089895   UniProtKB: Q8N3Y73   

Export aliases for SDR16C5 gene to outside databases

Previous GC identifers: GC08M057376 GC08M052679


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SDR16C5 Gene:
RDHE2 belongs to a family of short-chain alcohol dehydrogenases/reductases that catalyze the first and
rate-limiting step that generates retinaldehyde from retinol (Matsuzaka et al., 2002 (PubMed 12372410)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for SDR16C5 Gene: 
SDR16C5 (short chain dehydrogenase/reductase family 16C, member 5) is a protein-coding gene. Diseases associated with SDR16C5 include retinitis, and alcoholism, and among its related super-pathways are Drug metabolism - cytochrome P450 and retinoate biosynthesis II. GO annotations related to this gene include retinol dehydrogenase activity and nucleotide binding. An important paralog of this gene is HSD17B13.

UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7
Function: Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions.
Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or
11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SDR16C5 gene promoter:
         c-Fos   AP-1   FOXF2   JunB   Fra-1   FosB   JunD   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDR16C5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SDR16C5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDR16C5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.1   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.1

SDR16C5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDR16C5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M057212:  view genomic region     (about GC identifiers)

Start:
57,212,569 bp from pter      End:
57,233,335 bp from pter
Size:
20,767 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7 (See protein sequence)
Recommended Name: Epidermal retinol dehydrogenase 2  
Size: 309 amino acids; 34095 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAB71545.1; Type=Frameshift; Positions=226;
Secondary accessions: B4DGK2 Q330K3 Q8TDV9 Q96LX1
Alternative splicing: 2 isoforms:  Q8N3Y7-1   Q8N3Y7-2   

Explore the universe of human proteins at neXtProt for SDR16C5: NX_Q8N3Y7

Explore proteomics data for SDR16C5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N3Y7

  • SDR16C5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SDR16C5 Protein Expression
    REFSEQ proteins: NP_620419.2  
    ENSEMBL proteins: 
     ENSP00000379947   ENSP00000307607   ENSP00000431010  

    Human Recombinant Protein Products for SDR16C5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SDR16C5
    OriGene Protein Over-expression Lysate for SDR16C5
    OriGene MassSpec for SDR16C5 
    OriGene Custom Protein Services for SDR16C5
    GenScript Custom Purified and Recombinant Proteins Services for SDR16C5
    Novus Biologicals SDR16C5 Proteins
    Novus Biologicals SDR16C5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SDR16C5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA18926804
    GO:0016021integral to membrane IEA--

    SDR16C5 for ontologies           About GeneDecksing



    SDR16C5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SDR16C5
    GenScript Custom Superior Antibodies Services for SDR16C5
    Novus Biologicals SDR16C5 Antibodies
    Abcam antibodies for SDR16C5
    Cloud-Clone Corp. Antibodies for SDR16C5 
    ThermoFisher Antibodies for SDR16C5
    LSBio Antibodies in human, mouse, rat for SDR16C5 

    Assay Products for SDR16C5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SDR16C5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SDR16C5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SDR16C5 
    Cloud-Clone Corp. CLIAs for SDR16C5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    3 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8N3Y7

    ProtoNet protein and cluster: Q8N3Y7

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    SDR16C5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RDHE2_HUMAN, Q8N3Y7
    Function: Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions.
    Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or
    11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH
    Catalytic activity: All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) =
    all-trans-retinal-[cellular-retinol-binding-protein] + NADH

         Enzyme Number (IUBMB): EC 1.1.1.1051

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004745retinol dehydrogenase activity IDA18926804
    GO:0016491oxidoreductase activity ----
         
    SDR16C5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SDR16C5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SDR16C5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SDR16C5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SDR16C5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDR16C5
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SDR16C5:
    hsa-miR-515-5p hsa-miR-3140-3p hsa-miR-548g hsa-miR-3143 hsa-miR-330-3p hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidSDR16C5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SDR16C5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDR16C5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SDR16C5
    Sirion Biotech Customized adenovirus for overexpression of SDR16C5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SDR16C5 (see all 8)
    OriGene ORF clones in mouse, rat for SDR16C5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SDR16C5 (NM_138969)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDR16C5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDR16C5
    Sirion Biotech Customized lentivirus for stable overexpression of SDR16C5 
                         Customized lentivirus expression plasmids for stable overexpression of SDR16C5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SDR16C5
    Search LifeMap BioReagents cell lines for SDR16C5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR16C5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SDR16C5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Drug metabolism - cytochrome P450
    Retinol metabolism0.39
    2retinoate biosynthesis II
    retinoate biosynthesis I0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SDR16C5
        retinoate biosynthesis I


    1         Kegg Pathway  (Kegg details for SDR16C5):
        Retinol metabolism

    UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7
    Pathway: Cofactor metabolism; retinol metabolism


    SDR16C5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SDR16C5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SDR16C5 (ENSP000003076074) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    EXTL1ENSP000003633984STRING: ENSP00000363398
    NLKENSP000003846254STRING: ENSP00000384625
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0042572retinol metabolic process IEA--
    GO:0042574retinal metabolic process IDA18926804
    GO:0043616keratinocyte proliferation IMP12372410
    GO:0050908detection of light stimulus involved in visual perception NAS12407145

    SDR16C5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SDR16C5 (RDHE2)

    Search CenterWatch for drugs/clinical trials and news about SDR16C5 / RDHE2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SDR16C5 gene: 
    NM_138969.2  

    Unigene Cluster for SDR16C5:

    Short chain dehydrogenase/reductase family 16C, member 5
    Hs.170673  [show with all ESTs]
    Unigene Representative Sequence: NM_138969
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396721(uc003xsy.1 uc010lyk.1 uc010lyl.1) ENST00000303749
    ENST00000522671
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDR16C5
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SDR16C5:
    hsa-miR-515-5p hsa-miR-3140-3p hsa-miR-548g hsa-miR-3143 hsa-miR-330-3p hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidSDR16C5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SDR16C5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDR16C5
    Clone
    Products:
         
    OriGene clones in human, mouse for SDR16C5 (see all 8)
    OriGene ORF clones in mouse, rat for SDR16C5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SDR16C5 (NM_138969)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDR16C5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDR16C5
    Sirion Biotech Customized lentivirus for stable overexpression of SDR16C5 
                         Customized lentivirus expression plasmids for stable overexpression of SDR16C5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SDR16C5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDR16C5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDR16C5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDR16C5

    Additional mRNA sequence: 

    AB083038.1 AK057667.1 AK095159.1 AK294634.1 AY444559.1 BC037219.1 BC064525.1 

    3 DOTS entries:

    DT.436976  DT.100019872  DT.91821182 

    24/46 AceView cDNA sequences (see all 46):

    BE222471 BC037219 BM126305 CK904613 BC064525 NM_138969 BM766000 AK057667 
    BM980982 AI340037 CK904612 BM921464 AA295728 AB083038 BM126028 BM982104 
    BI824275 AI440266 AA507036 BM054750 BM068766 CD701414 AK095159 BE670640 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SDR16C5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                  
    SP2:                                                  -               
    SP3:                          -                       -               


    ECgene alternative splicing isoforms for SDR16C5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SDR16C5 expression in normal human tissues (normalized intensities)      SDR16C5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATGGATGG
    SDR16C5 Expression
    About this image


    SDR16C5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate

    See SDR16C5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SDR16C5

    SOURCE GeneReport for Unigene cluster: Hs.170673

    UniProtKB/Swiss-Prot: RDHE2_HUMAN, Q8N3Y7
    Tissue specificity: Detected in adult lung. Detected at low levels in adult brain, heart, testis, placenta,
    cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin
    keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients.
    Detected in fetal kidney, skin and lung

        SABiosciences Custom PCR Arrays for SDR16C5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SDR16C5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDR16C5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDR16C5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDR16C5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR16C5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SDR16C5 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdr16c51 , 5 short chain dehydrogenase/reductase family 16C, member more1, 5 82.36(n)1
    80.19(a)1
      4 (2.23 cM)5
    2422851  NM_181989.11  NP_871789.11 
     39959365 
    chicken
    (Gallus gallus)
    Aves SDR16C51 short chain dehydrogenase/reductase family 16C, member more 64.55(n)
    60.87(a)
      421130  NM_001031022.1  NP_001026193.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    51(a)
    49(a)
    (see all 5)
    possible ortholog
    1 ↔ many
    (see all 5)
    GL343244.1(28297-47817)
    GL343656.1(226706-235688)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.294442 Xenopus laevis transcribed sequence with weak similarity more 75.39(n)    BX846538.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.264312 Danio rerio cDNA clone MGC63829 IMAGE3816610, complete more 79.36(n)    BC054138.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG156291 CG15629 48.46(n)
    40.22(a)
      33679  NM_135015.1  NP_608859.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-191 Protein DHS-19 58.36(n)
    52.75(a)
      179578  NM_073514.4  NP_505915.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YDL114W1 hypothetical protein 44.5(n)
    30.62(a)
      851444   NP_010169.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSD61 hydroxysteroid dehydrogenase 6 40.42(n)
    29.17(a)
      835149  NM_124455.2  NP_199890.1 


    ENSEMBL Gene Tree for SDR16C5 (if available)
    TreeFam Gene Tree for SDR16C5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SDR16C5 gene
    HSD17B132  RDH102  HSD17B112  DHRS32  
    4 SIMAP similar genes for SDR16C5 using alignment to 2 protein entries:     RDHE2_HUMAN (see all proteins):
    HSD17B13    RDH10    DHRS3    HSD17B11

    SDR16C5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SDR16C5
    PGOHUM00000258343


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/424 SNPs in SDR16C5 are shown (see all 424)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3732847101,2
    C--57222853(+) GAGGA-/AGGAGGAG 1 -- int10--------
    rs1999950111,2
    C--57222894(+) GGAGGA/GGGAAG 1 -- int10--------
    rs582764861,2
    C--57223290(+) AAAAA-/GAAAAAGA 2 -- int1 cds11Minor allele frequency- GAA:0.00NA 2
    rs1131968391,2
    C--57223290(+) AAAAAA/GAAAAA 1 -- int12Minor allele frequency- G:0.00WA CSA 3
    rs358698301,2
    C--57225337(+) CCAAG-/TT/TTT
            
    TTTTT
    1 -- int12NA 4
    rs1400219671,2
    --57309880(+) GAAACA/GGGCAT 1 -- int10--------
    rs1859687471,2
    C--57309883(+) ACGGGC/TATGAC 1 -- int10--------
    rs1895246591,2
    --57309961(+) ATCCAC/TTAATT 1 -- int10--------
    rs1498452201,2
    --57310174(+) TCCCCA/GAAGAG 1 -- int10--------
    rs1817988431,2
    --57310356(+) GTGGAA/GTAAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SDR16C5 (57212569 - 57233335 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SDR16C5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737024CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SDR16C5
    DNA2.0 Custom Variant and Variant Library Synthesis for SDR16C5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608989    OMIM disorders: --

    4 diseases for SDR16C5:    About MalaCards
    retinitis    alcoholism    psoriasis    tuberculosis


    SDR16C5 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SDR16C5 (0 documents)

    Export disorders for SDR16C5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SDR16C5 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with SDR16C5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. (PubMed id 12372410)1, 2, 3, 9 Matsuzaka Y....Inoko H. (2002)
    2. Biochemical characterization of human epidermal retinol dehydrogenase 2. (PubMed id 18926804)1, 2, 9 Lee S.-A.... Kedishvili N.Y. (2009)
    3. hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis. (PubMed id 15457346)1, 2 Matsuzaka Y.... Inoko H. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genome-wide meta-analysis identifies 11 new loci for a nthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (2013)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 195814 HGNC: 30311 AceView: RDH-E2 Ensembl:ENSG00000170786 euGenes: HUgn195814
    ECgene: SDR16C5 Kegg: 195814 H-InvDB: SDR16C5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SDR16C5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SDR16C5 gene:
    Search GeneIP for patents involving SDR16C5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SDR16C5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SDR16C5  
     OriGene MassSpec something-or-other for SDR16C5   OriGene clones in human, mouse for SDR16C5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SDR16C5   OriGene Purified Protein for SDR16C5  
     OriGene ORF clones in mouse, rat for SDR16C5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SDR16C5   OriGene Custom Protein Services for SDR16C5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDR16C5
     QIAGEN SeqTarget long-range PCR primers for resequencing SDR16C5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDR16C5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDR16C5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDR16C5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDR16C5
     GenScript Custom Purified and Recombinant Proteins Services for SDR16C5 GenScript cDNA clones with any tag delivered in your preferred vector for SDR16C5
     GenScript Custom Assay Services for SDR16C5 GenScript Custom Superior Antibodies Services for SDR16C5
     GenScript Custom overexpressing Cell Line Services for SDR16C5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SDR16C5 promoter
     Search Chromatin IP Primers for SDR16C5
     RT2 qPCR Primer Assay in human, mouse, rat SDR16C5
     Search GNC Networks for SDR16C5
     SABiosciences Custom PCR Arrays for SDR16C5
     Search Tocris compounds for SDR16C5 (RDHE2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SDR16C5 antibodies
     SDR16C5 proteins
     SDR16C5 lysates
     Antibodies for SDR16C5
     See all of Abcam's Antibodies, Kits and Proteins for SDR16C5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SDR16C5
     Antibodies for SDR16C5
     ELISAs for SDR16C5
     CLIAs for SDR16C5
     Search LifeMap BioReagents cell lines for SDR16C5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDR16C5
     SwitchGear 3'UTR luciferase reporter plasmids for SDR16C5
     SwitchGear Promoter luciferase reporter plasmids for SDR16C5
     ThermoFisher Antibodies for SDR16C5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDR16C5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SDR16C5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SDR16C5
    Customized:
     lentivirus for stable overexpression of SDR16C5
     lentivirus expression plasmids for stable overexpression of SDR16C5
     adenovirus for overexpression of SDR16C5
     LSBio Antibodies in human, mouse, rat for SDR16C5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SDR16C5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4