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Aliases for SDPR Gene

Aliases for SDPR Gene

  • Serum Deprivation Response 2 3
  • Phosphatidylserine Binding Protein 2 3
  • Phosphatidylserine-Binding Protein 3 4
  • Cavin-2 3 4
  • PS-P68 3 4
  • Serum Deprivation Response (Phosphatidylserine-Binding Protein) 2
  • Serum Deprivation Response (Phosphatidylserine Binding Protein) 2
  • CAVIN2 3
  • SDR 3

External Ids for SDPR Gene

Previous GeneCards Identifiers for SDPR Gene

  • GC02M190880
  • GC02M191402
  • GC02M192663
  • GC02M192902
  • GC02M192525
  • GC02M192407
  • GC02M184557

Summaries for SDPR Gene

Entrez Gene Summary for SDPR Gene

  • This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]

GeneCards Summary for SDPR Gene

SDPR (Serum Deprivation Response) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and phosphatidylserine binding. An important paralog of this gene is PTRF.

UniProtKB/Swiss-Prot for SDPR Gene

  • May play a role in targeting PRKCA to caveolae.

Gene Wiki entry for SDPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDPR Gene

Genomics for SDPR Gene

Regulatory Elements for SDPR Gene

Genomic Location for SDPR Gene

191,834,302 bp from pter
191,847,280 bp from pter
12,979 bases
Minus strand

Genomic View for SDPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDPR Gene

Proteins for SDPR Gene

  • Protein details for SDPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serum deprivation-response protein
    Protein Accession:

    Protein attributes for SDPR Gene

    425 amino acids
    Molecular mass:
    47173 Da
    Quaternary structure:
    • Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC.
    • Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine

neXtProt entry for SDPR Gene

Proteomics data for SDPR Gene at MOPED

Post-translational modifications for SDPR Gene

Other Protein References for SDPR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SDPR

No data available for DME Specific Peptides for SDPR Gene

Domains & Families for SDPR Gene

Protein Domains for SDPR Gene


Suggested Antigen Peptide Sequences for SDPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PTRF/SDPR family.
  • Belongs to the PTRF/SDPR family.
genes like me logo Genes that share domains with SDPR: view

No data available for Gene Families for SDPR Gene

Function for SDPR Gene

Molecular function for SDPR Gene

GENATLAS Biochemistry:
serum deprivation response gene,specifically induced during growth arrest as elicited by serum starvation but not in contact-inhibited fibroblasts,downregulated during GO/S transition,targetting of protein kinase alpha and delta to caveolae
UniProtKB/Swiss-Prot Function:
May play a role in targeting PRKCA to caveolae.
UniProtKB/Swiss-Prot Induction:
Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.

Gene Ontology (GO) - Molecular Function for SDPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 2390065
GO:0005080 protein kinase C binding IBA --
GO:0005515 protein binding IPI 19722192
GO:0005543 phospholipid binding TAS 10191091
genes like me logo Genes that share ontologies with SDPR: view
genes like me logo Genes that share phenotypes with SDPR: view

Animal Models for SDPR Gene

MGI Knock Outs for SDPR:
  • Sdpr tm1(KOMP)Vlcg

Animal Model Products

miRNA for SDPR Gene

miRTarBase miRNAs that target SDPR

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDPR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SDPR Gene

Localization for SDPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDPR Gene

Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae.

Subcellular locations from

Jensen Localization Image for SDPR Gene COMPARTMENTS Subcellular localization image for SDPR gene
Compartment Confidence
cytosol 5
plasma membrane 5
chloroplast 2
peroxisome 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SDPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18332105
GO:0005829 cytosol IDA 2390065
GO:0005901 caveola IBA --
GO:0045121 membrane raft IDA 25204797
genes like me logo Genes that share ontologies with SDPR: view

Pathways & Interactions for SDPR Gene

SuperPathways for SDPR Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDPR Gene


No data available for Pathways by source and SIGNOR curated interactions for SDPR Gene

Drugs & Compounds for SDPR Gene

(1) Drugs for SDPR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(503) Additional Compounds for SDPR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with SDPR: view

Transcripts for SDPR Gene

mRNA/cDNA for SDPR Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(140) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SDPR Gene

Serum deprivation response:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDPR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDPR Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1: - -

Relevant External Links for SDPR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDPR Gene

mRNA expression in normal human tissues for SDPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SDPR Gene

This gene is overexpressed in Platelet (18.9) and Nasopharynx (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDPR Gene

SOURCE GeneReport for Unigene cluster for SDPR Gene Hs.26530

mRNA Expression by UniProt/SwissProt for SDPR Gene

Tissue specificity: Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
genes like me logo Genes that share expression patterns with SDPR: view

Protein tissue co-expression partners for SDPR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SDPR Gene

Orthologs for SDPR Gene

This gene was present in the common ancestor of chordates.

Orthologs for SDPR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SDPR 35
  • 86.4 (n)
  • 87.03 (a)
  • 79 (a)
(Mus musculus)
Mammalia Sdpr 35
  • 82.93 (n)
  • 83.97 (a)
Sdpr 16
Sdpr 36
  • 84 (a)
(Pan troglodytes)
Mammalia SDPR 35
  • 99.53 (n)
  • 99.53 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Sdpr 35
  • 82.49 (n)
  • 82.49 (a)
(Canis familiaris)
Mammalia SDPR 36
  • 73 (a)
(Monodelphis domestica)
Mammalia SDPR 36
  • 73 (a)
(Gallus gallus)
Aves SDPR 35
  • 66.13 (n)
  • 61.66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495531 35
  • 67.87 (n)
  • 75.2 (a)
(Danio rerio)
Actinopterygii sdprb 35
  • 66.44 (n)
  • 67.11 (a)
sdpra 36
  • 36 (a)
sdprb 36
  • 47 (a)
Species with no ortholog for SDPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDPR Gene

Gene Tree for SDPR (if available)
Gene Tree for SDPR (if available)

Paralogs for SDPR Gene

Paralogs for SDPR Gene

(2) SIMAP similar genes for SDPR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SDPR: view

Variants for SDPR Gene

Sequence variations from dbSNP and Humsavar for SDPR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1128965 -- 191,835,674(-) AAGAA(A/G)CTGAG utr-variant-3-prime
rs4072961 -- 191,837,620(+) TCTTG(C/G)CTCTC intron-variant
rs4072962 -- 191,838,120(+) GAAAA(A/C)TAACT intron-variant
rs4074881 -- 191,838,449(-) GCGTC(A/G)ACACA intron-variant
rs4076005 -- 191,837,681(+) GCAAC(A/C)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDPR Gene

Variant ID Type Subtype PubMed ID
nsv834494 CNV Gain 17160897

Variation tolerance for SDPR Gene

Residual Variation Intolerance Score: 74.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDPR Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDPR Gene

Disorders for SDPR Gene

Relevant External Links for SDPR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SDPR: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDPR Gene

Publications for SDPR Gene

  1. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. (PMID: 10191091) Gustincich S. … Schneider C. (Genomics 1999) 2 23 67
  2. Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity. (PMID: 14973064) Alexander D.B. … Goldberg G.S. (Cancer Res. 2004) 23 67
  3. Serum deprivation response gene is induced by serum starvation but not by contact inhibition. (PMID: 8241023) Gustincich S. … Schneider C. (Cell Growth Differ. 1993) 2 67
  4. Purification and characterization of a major phosphatidylserine- binding phosphoprotein from human platelets. (PMID: 2390065) Burgener R. … Baggiolini M. (Biochem. J. 1990) 23 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for SDPR Gene

Sources for SDPR Gene

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