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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SDPR Gene

protein-coding   GIFtS: 51
GCID: GC02M192663

serum deprivation response

(Previous names: serum deprivation response (phosphatidylserine-binding...)
 Explore 4 diseases affiliated with
SDPR via our new
 Human Malady Compendium 
Biological research products
for SDPR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Serum Deprivation Response1 2     Serum Deprivation Response (Phosphatidylserine Binding Protein)1
PS-P681     Serum Deprivation Response (Phosphatidylserine-Binding Protein)1
SDR1 2 5     Phosphatidylserine Binding Protein2
CAVIN21 2     Serum Deprivation-Response Protein2
Cavin-23     Cavin-23
Phosphatidylserine-Binding Protein2 3     

External Ids:    HGNC: 106901   Entrez Gene: 84362   Ensembl: ENSG000001684977   OMIM: 6067285   UniProtKB: O958103   

Export aliases for SDPR gene to outside databases

Previous GC identifers: GC02M190880 GC02M191402 GC02M192902 GC02M192525 GC02M192407 GC02M184557


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SDPR:
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells.
This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript
release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in
caveolae deformation and membrane tubulation.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: SDPR_HUMAN, O95810
Function: May play a role in targeting PRKCA to caveolae (By similarity)

Gene Wiki entry for SDPR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SDPR gene promoter:
         HOXA9B   HOXA9   HOXA3   Pax-5   CUTL1   POU3F2   E47   Cart-1   Hand1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDPR promoter sequence
   Search SABiosciences Chromatin IP Primers for SDPR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32-q33   Ensembl cytogenetic band:  2q32.3   HGNC cytogenetic band: 2q32-q33

SDPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDPR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M192663:  view genomic region     (about GC identifiers)

Start:
192,699,028 bp from pter      End:
192,712,006 bp from pter
Size:
12,979 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SDPR_HUMAN, O95810 (See protein sequence)
Recommended Name: Serum deprivation-response protein  
Size: 425 amino acids; 47173 Da
Subunit: Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the
transactivation of NPPA by MURC
Subcellular location: Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae
Miscellaneous: Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic
acid and phosphatidylinositol. Does not bind phosphatidylcholine

Explore the universe of human proteins at neXtProt for SDPR: NX_O95810

Post-translational modifications:

  • Phosphorylated on Ser residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95810

  • SDPR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004648.1  
    ENSEMBL proteins: 
     ENSP00000305675  

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    Uscn Proteins for SDPR

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol IDA2390065
    GO:0005886plasma membrane IDA--
    GO:0005901caveola IEA--


    SDPR for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SDPR for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026752 Cavin_fam

    Graphical View of Domain Structure for InterPro Entry O95810

    ProtoNet protein and cluster: O95810

    UniProtKB/Swiss-Prot: SDPR_HUMAN, O95810
    Similarity: Belongs to the PTRF/SDPR family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SDPR_HUMAN, O95810
    Function: May play a role in targeting PRKCA to caveolae (By similarity)
    Induction: Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact
    inhibition. Down-regulated during synchronous cell cycle re-entry

         Genatlas biochemistry entry for SDPR:
    serum deprivation response gene,specifically induced during growth arrest as elicited by serum starvation but not in
    contact-inhibited fibroblasts,downregulated during GO/S transition,targetting of protein kinase alpha and delta to
    caveolae

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IDA2390065
    GO:0005515protein binding IPI19722192
    GO:0005543phospholipid binding TAS10191091


    SDPR for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SDPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for SDPR (O958101, 2, 3 ENSP000003056754) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLEKHF2Q9H8W42, 3, ENSP000003223734MINT-67941 I2D: score=5 STRING: ENSP00000322373
    CAV1Q031352, 3, ENSP000003391914MINT-7234712 I2D: score=1 STRING: ENSP00000339191
    PRKCDBPQ969G52, 3, ENSP000003072924MINT-7234727 I2D: score=1 STRING: ENSP00000307292
    PLEKP085671, 3, ENSP000002343134EBI-742141,EBI-2565501 I2D: score=1 STRING: ENSP00000234313
    NUDT18Q6ZVK82, 3, ENSP000003078524MINT-66244 I2D: score=5 STRING: ENSP00000307852
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SDPR

    10/504 HMDB Compounds for SDPR (see all 504)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PS(16:0/16:0)Phosphatidylserine (16:0/16:0) (see all 14)3036-82-612486725
    CalciumCa (see all 2)7440-70-2--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----
    Search CenterWatch for drugs/clinical trials and news about SDPR 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for SDPR gene: 
    NM_004657.5  

    Unigene Cluster for SDPR:

    Serum deprivation response
    Hs.26530  [show with all ESTs]
    Unigene Representative Sequence: NM_004657
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304141(uc002utb.3)

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    Additional cDNA sequence: 

    AF085481.1 AK026943.1 AK290378.1 AK311055.1 BC016475.1 

    5 DOTS entries:

    DT.314257  DT.100780315  DT.40312658  DT.120973873  DT.100651923 

    24/140 AceView cDNA sequences (see all 140):

    CB268675 AA642646 BM974509 NM_004657 AA676951 AK026943 BQ002697 BC016475 
    AL577436 BX644670 AA564136 Z30112 AI287634 BG059338 AI378981 AU100074 
    AI282599 BM801620 AL597564 AA150400 CA406577 AA937365 BP364618 BG059100 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SDPR    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:        -     -         
    SP2:                        


    ECgene alternative splicing isoforms for SDPR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SDPR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SDPR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    BoneMandibular ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium

    See SDPR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SDPR

    SOURCE GeneReport for Unigene cluster: Hs.26530

    UniProtKB/Swiss-Prot: SDPR_HUMAN, O95810
    Tissue specificity: Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver,
    pancreas, placenta, and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SDPR gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SDPR1 serum deprivation response (phosphatidylserine binding more 66.58(n)
    61.73(a)
      424047  XM_421903.2  XP_421903.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    63(a)
    1 ↔ 1
    2(133679602-133719768)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD328102.12   -- 76.29(n)    CD328102.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK127005.12   -- 75.54(n)    CK127005.1 


    ENSEMBL Gene Tree for SDPR (if available)
    TreeFam Gene Tree for SDPR (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SDPR gene
    PRKCDBP2  PTRF2  MURC2  
    2 SIMAP similar genes for SDPR using alignment to 1 protein entry:     SDPR_HUMAN:
    PRKCDBP    PTRF

    SDPR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/241 NCBI SNPs in SDPR are shown (see all 241    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896730151,2
    --192698563(+) CAGCTA/GGTTTC 1 -- ds50010--------
    rs1816161051,2
    --192698582(+) CAGCTA/GCAAGA 1 -- ds50010--------
    rs799132921,2
    F,--192698793(+) TATCAA/GACTCA 1 -- ds50011Minor allele frequency- G:0.06NA 120
    rs1861368121,2
    --192698798(+) AACTCA/GTCAAG 1 -- ds50010--------
    rs1393499831,2
    --192699174(+) ATCCTA/GTCCCT 1 -- ut310--------
    rs1496187411,2
    --192699443(+) AGTTAA/GGAAAT 1 -- ut310--------
    rs1907914331,2
    --192699473(+) AATATA/GTAAAT 1 -- ut310--------
    rs748948841,2
    --192699502(+) AAATTC/GCCATT 1 -- ut310--------
    rs2010726551,2
    C--192699637(+) TAGTAG/TGAGCT 1 -- ut310--------
    rs725400601,2
    C,--192699638(+) TATGA-/GGCTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SDPR (192699028 - 192712006 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SDPR: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SDPR for disorders           About GeneDecksing

    OMIM gene information: 606728    OMIM disorders: --

    4 diseases for SDPR:    About MalaCards
    spondylolisthesis    quadriplegia    cerebral palsy    cerebritis


    Export disorders for SDPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SDPR gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SDPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. (PubMed id 10191091)1, 2, 3, 9 Gustincich S.... Schneider C. (1999)
    2. Purification and characterization of a major phosphatidylserine- binding phosphoprotein from human platelets. (PubMed id 2390065)1, 2, 9 Burgener R.... Baggiolini M. (1990)
    3. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. (PubMed id 18332105)1, 2 Ogata T.... Oh H. (2008)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Serum deprivation response gene is induced by serum s tarvation but not by contact inhibition. (PubMed id 8241023)1, 3 Gustincich S. and Schneider C. (1993)
    7. Down-regulation of the cavin family proteins in breast cancer. (PubMed id 21913217)1 Bai L....Cong Y.S. (2012)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. SDPR induces membrane curvature and functions in the formation of caveolae. (PubMed id 19525939)1 Hansen C.G....Nichols B.J. (2009)
    10. Proteomic identification of pleckstrin-associated pro teins in platelets: possible interactions with actin. (PubMed id 19722192)1 Baig A....Haslam R.J. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8436 HGNC: 10690 AceView: SDPR Ensembl:ENSG00000168497 euGenes: HUgn8436
    ECgene: SDPR H-InvDB: SDPR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SDPR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for SDPR gene:
    Search GeneIP for patents involving SDPR

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