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Aliases for SDPR Gene

Aliases for SDPR Gene

  • Serum Deprivation Response 2 3 5
  • Phosphatidylserine-Binding Protein 3 4
  • Cavin-2 3 4
  • PS-P68 3 4
  • Serum Deprivation Response (Phosphatidylserine-Binding Protein) 2
  • Serum Deprivation Response (Phosphatidylserine Binding Protein) 2
  • Phosphatidylserine Binding Protein 2
  • Serum Deprivation-Response Protein 3
  • CAVIN2 3
  • SDR 3

External Ids for SDPR Gene

Previous GeneCards Identifiers for SDPR Gene

  • GC02M190880
  • GC02M191402
  • GC02M192663
  • GC02M192902
  • GC02M192525
  • GC02M192407
  • GC02M184557

Summaries for SDPR Gene

Entrez Gene Summary for SDPR Gene

  • This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]

GeneCards Summary for SDPR Gene

SDPR (Serum Deprivation Response) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and phosphatidylserine binding. An important paralog of this gene is PTRF.

UniProtKB/Swiss-Prot for SDPR Gene

  • May play a role in targeting PRKCA to caveolae.

Gene Wiki entry for SDPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDPR Gene

Genomics for SDPR Gene

Regulatory Elements for SDPR Gene

Enhancers for SDPR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F191843 1.2 FANTOM5 ENCODE 51.2 +1.4 1433 5.3 ATF1 MLX ZFP64 ARID4B ZNF48 SLC30A9 GATA2 SP5 NFYC PPARG SDPR LOC105373813 GC02P191798
GH02F191909 1.1 FANTOM5 Ensembl ENCODE 38.3 -63.3 -63254 1.4 JUND JUN BHLHE40 MAFK SDPR LOC105373813 NABP1 DNAJB1P1 GC02P192046
GH02F191950 2 Ensembl ENCODE 11 -103.3 -103271 0.9 BACH1 CHAMP1 ZNF316 NCOR1 FOS NFE2 TRIM24 MAFK NFE2L2 SMARCE1 SDPR LOC105373813 DNAJB1P1 GC02P192046
GH02F191849 0.5 FANTOM5 37.7 -2.3 -2298 0.1 ATF3 FOXK2 NR2F1 SDPR DNAJB1P1
GH02F191674 1.5 FANTOM5 ENCODE 10.5 +168.2 168237 8.4 PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NABP1 LOC105373813 SDPR GC02P191680
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SDPR on UCSC Golden Path with GeneCards custom track

Genomic Location for SDPR Gene

Chromosome:
2
Start:
191,834,302 bp from pter
End:
191,847,280 bp from pter
Size:
12,979 bases
Orientation:
Minus strand

Genomic View for SDPR Gene

Genes around SDPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SDPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SDPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDPR Gene

Proteins for SDPR Gene

  • Protein details for SDPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95810-SDPR_HUMAN
    Recommended name:
    Serum deprivation-response protein
    Protein Accession:
    O95810

    Protein attributes for SDPR Gene

    Size:
    425 amino acids
    Molecular mass:
    47173 Da
    Quaternary structure:
    • Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC.
    Miscellaneous:
    • Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.

neXtProt entry for SDPR Gene

Post-translational modifications for SDPR Gene

Other Protein References for SDPR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SDPR

No data available for DME Specific Peptides for SDPR Gene

Domains & Families for SDPR Gene

Gene Families for SDPR Gene

Protein Domains for SDPR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SDPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95810

UniProtKB/Swiss-Prot:

SDPR_HUMAN :
  • Belongs to the PTRF/SDPR family.
Family:
  • Belongs to the PTRF/SDPR family.
genes like me logo Genes that share domains with SDPR: view

Function for SDPR Gene

Molecular function for SDPR Gene

GENATLAS Biochemistry:
serum deprivation response gene,specifically induced during growth arrest as elicited by serum starvation but not in contact-inhibited fibroblasts,downregulated during GO/S transition,targetting of protein kinase alpha and delta to caveolae
UniProtKB/Swiss-Prot Function:
May play a role in targeting PRKCA to caveolae.
UniProtKB/Swiss-Prot Induction:
Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.

Gene Ontology (GO) - Molecular Function for SDPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 2390065
GO:0005080 protein kinase C binding IBA --
GO:0005515 protein binding IPI 19722192
GO:0005543 phospholipid binding TAS 10191091
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with SDPR: view
genes like me logo Genes that share phenotypes with SDPR: view

Animal Models for SDPR Gene

MGI Knock Outs for SDPR:
  • Sdpr tm1(KOMP)Vlcg

Animal Model Products

miRNA for SDPR Gene

miRTarBase miRNAs that target SDPR

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SDPR

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SDPR Gene

Localization for SDPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDPR Gene

Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae. {ECO:0000250 UniProtKB:Q66H98}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SDPR gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
mitochondrion 2
golgi apparatus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SDPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 18332105
GO:0005829 cytosol IEA,IDA 2390065
GO:0005901 caveola IBA --
GO:0016020 membrane IEA --
GO:0045121 membrane raft IDA 25204797
genes like me logo Genes that share ontologies with SDPR: view

Pathways & Interactions for SDPR Gene

No Data Available

Gene Ontology (GO) - Biological Process for SDPR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SDPR Gene

Drugs & Compounds for SDPR Gene

(1) Drugs for SDPR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(503) Additional Compounds for SDPR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with SDPR: view

Transcripts for SDPR Gene

mRNA/cDNA for SDPR Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(140) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SDPR Gene

Serum deprivation response:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SDPR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDPR Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1: - -
SP2:

Relevant External Links for SDPR Gene

GeneLoc Exon Structure for
SDPR
ECgene alternative splicing isoforms for
SDPR

Expression for SDPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SDPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SDPR Gene

This gene is overexpressed in Platelet (18.9) and Nasopharynx (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDPR Gene



Protein tissue co-expression partners for SDPR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SDPR Gene:

SDPR

SOURCE GeneReport for Unigene cluster for SDPR Gene:

Hs.26530

mRNA Expression by UniProt/SwissProt for SDPR Gene:

O95810-SDPR_HUMAN
Tissue specificity: Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
genes like me logo Genes that share expression patterns with SDPR: view

No data available for mRNA differential expression in normal tissues for SDPR Gene

Orthologs for SDPR Gene

This gene was present in the common ancestor of chordates.

Orthologs for SDPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SDPR 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia SDPR 34 35
  • 86.4 (n)
mouse
(Mus musculus)
Mammalia Sdpr 34 16 35
  • 82.93 (n)
rat
(Rattus norvegicus)
Mammalia Sdpr 34
  • 82.49 (n)
dog
(Canis familiaris)
Mammalia SDPR 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SDPR 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDPR 34
  • 66.13 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495531 34
  • 67.87 (n)
zebrafish
(Danio rerio)
Actinopterygii sdprb 34 35
  • 66.44 (n)
sdpra 35
  • 36 (a)
ManyToMany
Species where no ortholog for SDPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SDPR Gene

ENSEMBL:
Gene Tree for SDPR (if available)
TreeFam:
Gene Tree for SDPR (if available)

Paralogs for SDPR Gene

Paralogs for SDPR Gene

(2) SIMAP similar genes for SDPR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SDPR: view

Variants for SDPR Gene

Sequence variations from dbSNP and Humsavar for SDPR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10167187 -- 191,836,667(+) ACGGC(A/G)CCGGA reference, synonymous-codon
rs10176958 -- 191,839,348(+) CTTCT(A/G)AAGGA intron-variant
rs10194291 -- 191,837,527(+) GCGAA(C/G)AGTGA intron-variant
rs111269086 -- 191,840,932(+) AGACC(A/G)TAAAT intron-variant
rs111710348 -- 191,847,374(+) GGCTG(C/T)TATGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SDPR Gene

Variant ID Type Subtype PubMed ID
nsv584068 CNV loss 21841781
nsv834494 CNV gain 17160897

Variation tolerance for SDPR Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SDPR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SDPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDPR Gene

Disorders for SDPR Gene

Relevant External Links for SDPR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SDPR

No disorders were found for SDPR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SDPR Gene

Publications for SDPR Gene

  1. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. (PMID: 10191091) Gustincich S. … Schneider C. (Genomics 1999) 2 3 4 22 64
  2. Purification and characterization of a major phosphatidylserine- binding phosphoprotein from human platelets. (PMID: 2390065) Burgener R. … Baggiolini M. (Biochem. J. 1990) 3 4 22 64
  3. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. (PMID: 18332105) Ogata T. … Oh H. (Mol. Cell. Biol. 2008) 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SDPR Gene

Sources for SDPR Gene

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