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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SDK2 Gene

protein-coding GIFtS: 51
GCID: GC17M071330

sidekick cell adhesion molecule 2

(Previous name: sidekick homolog 2 (chicken) )

Explore 6 diseases affiliated with
SDK2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sidekick Cell Adhesion Molecule 2¹ ²
KIAA1514¹ ³
FLJ10832¹
Sidekick Homolog 2 (Chicken)¹
Protein Sidekick-2²
Sidekick Homolog 2²

External Ids:	HGNC: 19308¹	Entrez Gene: 54549²	Ensembl: ENSG00000069188⁷	OMIM: 607217⁵	UniProtKB: Q58EX2³

Export aliases for SDK2 gene to outside databases

Previous GC identifers: GC17P071133 GC17M074374 GC17M071798 GC17M071930 GC17M068842 GC17M066739

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SDK2:

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin

domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and

intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface.

This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the

specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus

has been observed but the full-length nature of additional variants has not yet been determined. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: SDK2_HUMAN, Q58EX2

Function: Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons (By similarity)

Gene Wiki entry for SDK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SDK2 gene promoter:
LHX3b/Lhx3b AML1a p53 Pax-5 Egr-1 POU3F2 S8 Pax-3 LHX3a/Lhx3a RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SDK2 promoter sequence

Search SABiosciences Chromatin IP Primers for SDK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q21.31

SDK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDK2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M071330: view genomic region (about GC identifiers)

Start:	71,330,523 bp from pter	End:	71,640,228 bp from pter
Size:	309,706 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SDK2_HUMAN, Q58EX2 (See protein sequence)

Recommended Name: Protein sidekick-2 precursor

Size: 2172 amino acids; 239396 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Sequence caution: Sequence=BAA91841.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

4 PDB 3D structures from and Proteopedia for SDK2:

1WF5 (3D)

1WFN (3D)

1WFO (3D)

1WIS (3D)

Secondary accessions: A6NMR8 C9JA57 Q86VY3 Q9NTD2 Q9NVB3 Q9P214

Alternative splicing: 4 isoforms: Q58EX2-1 Q58EX2-2 Q58EX2-3 Q58EX2-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SDK2: NX_Q58EX2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q58EX2

SDK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001138424.1

ENSEMBL proteins:

ENSP00000376421 ENSP00000407098 ENSP00000373378

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SDK2 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SDK2
	GenScript Custom Purified and Recombinant Proteins Services for SDK2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SDK2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

SDK2 for ontologies About GeneDecksing

SDK2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SDK2
	GenScript Custom Superior Antibodies Services for SDK2
	Novus Biologicals SDK2 Antibody
	Search for Antibodies for SDK2 at Abcam
	Uscn Antibodies for SDK2
	Search ThermoFisher Antibodies for SDK2

Assay Products for SDK2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SDK2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SDK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SDK2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR003961 Fibronectin_type3

IPR013098 Ig_I-set

Graphical View of Domain Structure for InterPro Entry Q58EX2

ProtoNet protein and cluster: Q58EX2

1 Blocks protein family: IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: SDK2_HUMAN, Q58EX2

Similarity: Contains 13 fibronectin type-III domains

Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SDK2_HUMAN, Q58EX2

Function: Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SDK2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDK2
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate SDK2 (see all 64):
		hsa-miR-411* hsa-miR-579 hsa-miR-576-3p hsa-miR-26a-2* hsa-miR-607 hsa-miR-3938 hsa-miR-328 hsa-miR-379*

		SwitchGear 3'UTR luciferase reporter plasmid: SDK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDK2 (see all 7) OriGene shRNA RFP: SDK2 OriGene siRNA: SDK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDK2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SDK2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDK2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDK2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SDK2 (NM_001144952)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDK2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SDK2
		Search LifeMap BioReagents cell lines for SDK2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDK2

1 GenomeRNAi human phenotype for SDK2:

Increased S DNA content, incre

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SDK2

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--

SDK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SDK2
Search CenterWatch for drugs/clinical trials and news about SDK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SDK2 gene (2 alternative transcripts):

NM_001144952.1 NM_019064.3

Unigene Cluster for SDK2:

Sidekick cell adhesion molecule 2

Hs.435719 [show with all ESTs]

Unigene Representative Sequence: NM_001144952

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392650(uc002jjt.4 uc010dfm.3) ENST00000424778 ENST00000410094

ENST00000479356(uc010dfn.2) ENST00000585283 ENST00000388726

miRNA Products:		OriGene 3'-UTR Clone: SDK2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDK2
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate SDK2 (see all 64):
		hsa-miR-411* hsa-miR-579 hsa-miR-576-3p hsa-miR-26a-2* hsa-miR-607 hsa-miR-3938 hsa-miR-328 hsa-miR-379*

		SwitchGear 3'UTR luciferase reporter plasmid: SDK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDK2 (see all 7) OriGene shRNA RFP: SDK2 OriGene siRNA: SDK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDK2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDK2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDK2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SDK2 (NM_001144952)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SDK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDK2

Additional cDNA sequence:

AB040947.1 AK001694.1 AK021541.1 AK074994.1 AK091827.1 AL137357.1 BC045763.1 BC066363.1

10 DOTS entries:

DT.95243605 DT.95264269 DT.40295317 DT.100020642 DT.92025571 DT.97809983 DT.100665601 DT.92444812

DT.91649038 DT.95085740

24/73 AceView cDNA sequences (see all 73):

CR616107 AK001694 BX646558 AW662837 NM_019064 CD629651 AB040947 BM696523

AI222955 BU184456 AA906477 BM461616 AI138884 BM693647 AI365254 AA653137

AW173064 BU167329 AI379825 BQ182396 AL137357 BM669230 N23651 AL521243

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SDK2 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18a	·	18b	^	19	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35a	·	35b	^	36	^	37	^	38	^	39	^	40
SP1:																																	-
SP2:
SP3:																			-														-
SP4:
SP5:

ECgene alternative splicing isoforms for SDK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SDK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAATCCTGA

About this image

SDK2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See SDK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SDK2

SOURCE GeneReport for Unigene cluster: Hs.435719

SABiosciences Custom PCR Arrays for SDK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SDK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDK2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SDK2 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SDK2¹	sidekick homolog 2 (chicken)	82.33(n) 87.73(a)		395215 NM_204538.1 NP_989869.1
lizard (Anolis carolinensis)	Reptilia	SDK2⁶	--	88(a)	1 ↔ 1	2(96895912-96982778)
zebrafish (Danio rerio)	Actinopterygii	sdk2b¹	sidekick homolog 2b (chicken)	74.44(n) 81.55(a)		564922 XM_688240.4 XP_693332.4
fruit fly (Drosophila melanogaster)	Insecta	sdk¹	sidekick	26.84(n) 7.61(a)		31017 NM_057942.4 NP_477290.6
worm (Caenorhabditis elegans)	Secernentea	rig-4¹	Protein RIG-4	39.5(n) 31.28(a)		177597 NM_068938.5 NP_501339.2

ENSEMBL Gene Tree for SDK2 (if available)
TreeFam Gene Tree for SDK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SDK2 gene

CHL1² CNTN2² DSCAM² CNTN6² CNTN5² CNTN4² NFASC² NRCAM²

CNTN3² SDK1² DSCAML1² L1CAM² CNTN1²

5 SIMAP similar genes for SDK2 using alignment to 2 protein entries: SDK2_HUMAN (see all proteins):

SDK1 L1CAM MUSK PTPRS KIAA0992

SDK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150493046^1,2		--	71330124(+)	`TCCCCA/GAGGGC`	1	--	int¹		0	--	--	--	--
rs138320782^1,2		--	71330152(+)	`CCTGTC/TCCAGG`	1	--	int¹		0	--	--	--	--
rs184513407^1,2		--	71330176(+)	`ACTGTC/TGCAAA`	1	--	int¹		0	--	--	--	--
rs189821787^1,2		--	71330228(+)	`CTGGCA/GCAGAG`	1	--	int¹		0	--	--	--	--
rs9912740^1,2	C,F,A,H,	--	71330478(+)	`CAGGTG/TACCCC`	1	--	int¹		30		EA NA NS CSA WA	3330
rs181363258^1,2		--	71330513(+)	`ATGTTC/GCTTCA`	1	--	int¹		0	--	--	--	--
rs186024551^1,2		--	71330522(+)	`CAAATC/TTCCAA`	1	--	spd¹		0	--	--	--	--
rs3764369^1,2	H	--	71330608(-)	`TAAGAA/CAGAAA`	1	--	ut3¹		4		NS EA	418
rs77678500^1,2	C,	--	71330664(+)	`AGATAT/CATATT`	1	--	ut3¹		2		NA	122
rs3764368^1,2	H	--	71330691(-)	`ATGGCA/CGGTGT`	1	--	ut3¹		4		NS EA	414

HapMap Linkage Disequilibrium report for SDK2 (71330523 - 71580523 bp, first 250kb of SDK2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SDK2
2 CNVs: 102530 23529
1 Indel: 45585

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDK2

DNA2.0 Custom Variant and Variant Library Synthesis for SDK2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SDK2 for disorders           About GeneDecksing

OMIM gene information: 607217    OMIM disorders: --

6 diseases for SDK2:    About MalaCards

congenital stationary night blindness night blindness panic disorder blindness

nephropathy neuronitis

1 disease from the University of Copenhagen DISEASES database for SDK2:

Congenital stationary night blindness

Human Genome Epidemiology (HuGE) Navigator: SDK2 (1 document)

Export disorders for SDK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SDK2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SDK2)

Utopia: connect your pdf to the dynamic
world of online information

Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. (PubMed id 15213259)^{1, 3, 9} Kaufman L....Klotman P.E. (2004)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)^{1, 2} Zody M.C.... Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina. (PubMed id 12230981)^{1, 3} Yamagata M....Sanes J.R. (2002)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)¹ Otowa T....Okazaki Y. (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54549	HGNC: 19308	AceView: SDK2	Ensembl:ENSG00000069188	euGenes: HUgn54549
ECgene: SDK2	H-InvDB: SDK2

(According to HUGE)
About This Section

HUGE: KIAA1514

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SDK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SDK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SDK2 gene:
Search GeneIP for patents involving SDK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for SDK2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDK2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDK2
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	OriGene siRNA for SDK2		OriGene 3'-UTR Clone for SDK2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDK2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDK2
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDK2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDK2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDK2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDK2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDK2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDK2

	GenScript Custom Purified and Recombinant Proteins Services for SDK2		GenScript cDNA clones with any tag delivered in your preferred vector for SDK2
	GenScript Custom Assay Services for SDK2		GenScript Custom Superior Antibodies Services for SDK2
	GenScript Custom overexpressing Cell Line Services for SDK2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDK2

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDK2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SDK2 gene at Home site.

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SDK2 Gene

sidekick cell adhesion molecule 2

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Export list of displayed genes

SDK2 Gene

sidekick cell adhesion molecule 2

Aliasesfor SDK2 gene

Summariesfor SDK2 gene

Genomic Viewsfor SDK2 gene

Proteinsfor SDK2 gene

Protein Domains /Familiesfor SDK2 gene

Functionfor SDK2 gene

Pathways & Interactionsfor SDK2 gene

Drugs & Compoundsfor SDK2 gene

Transcriptsfor SDK2 gene

Expression for SDK2 gene

Orthologsfor SDK2 gene

Paralogsfor SDK2 gene

Genomic Variantsfor SDK2 gene

Disorders / Diseasesfor SDK2 gene

Publicationsfor SDK2 gene

External Searches for SDK2 gene

Genome Databases showing SDK2 gene

Other Databases showing SDK2 gene

Specialized Databases showing SDK2 gene

Intellectual Propertyfor SDK2 gene

Productsfor SDK2 gene

View Random Gene

Aliases
for SDK2 gene

Summaries
for SDK2 gene

Genomic Views
for SDK2 gene

Proteins
for SDK2 gene

Protein Domains /
Families
for SDK2 gene

Function
for SDK2 gene

Pathways & Interactions
for SDK2 gene

Drugs & Compounds
for SDK2 gene

Transcripts
for SDK2 gene

Expression
for SDK2 gene

Orthologs
for SDK2 gene

Paralogs
for SDK2 gene

Genomic Variants
for SDK2 gene

Disorders / Diseases
for SDK2 gene

Publications
for SDK2 gene

Intellectual Property
for SDK2 gene

Products
for SDK2 gene