Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SDK2 Gene

Aliases for SDK2 Gene

  • Sidekick Cell Adhesion Molecule 2 2 3
  • Sidekick Homolog 2 (Chicken) 2
  • KIAA1514 4

External Ids for SDK2 Gene

Previous GeneCards Identifiers for SDK2 Gene

  • GC17P071133
  • GC17M074374
  • GC17M071798
  • GC17M071930
  • GC17M068842
  • GC17M071330
  • GC17M066739

Summaries for SDK2 Gene

Entrez Gene Summary for SDK2 Gene

  • The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SDK2 Gene

SDK2 (Sidekick Cell Adhesion Molecule 2) is a Protein Coding gene. An important paralog of this gene is DSCAML1.

UniProtKB/Swiss-Prot for SDK2 Gene

  • Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons.

Gene Wiki entry for SDK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDK2 Gene

Genomics for SDK2 Gene

Regulatory Elements for SDK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SDK2 Gene

73,334,384 bp from pter
73,644,089 bp from pter
309,706 bases
Minus strand

Genomic View for SDK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDK2 Gene

Proteins for SDK2 Gene

  • Protein details for SDK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein sidekick-2
    Protein Accession:
    Secondary Accessions:
    • A6NMR8
    • C9JA57
    • Q86VY3
    • Q9NTD2
    • Q9NVB3
    • Q9P214

    Protein attributes for SDK2 Gene

    2172 amino acids
    Molecular mass:
    239396 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91841.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SDK2 Gene

    Alternative splice isoforms for SDK2 Gene


neXtProt entry for SDK2 Gene

Proteomics data for SDK2 Gene at MOPED

Post-translational modifications for SDK2 Gene

  • Glycosylation at Asn193, Asn403, Asn609, Asn743, Asn936, Asn948, Asn1102, Asn1256, and Asn1670
  • Modification sites at PhosphoSitePlus

Other Protein References for SDK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SDK2 Gene

Domains for SDK2 Gene

Gene Families for SDK2 Gene

  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Protein Domains for SDK2 Gene

Suggested Antigen Peptide Sequences for SDK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q58EX2
  • Contains 13 fibronectin type-III domains.
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with SDK2: view

Function for SDK2 Gene

Molecular function for SDK2 Gene

UniProtKB/Swiss-Prot Function:
Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons.

Gene Ontology (GO) - Molecular Function for SDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SDK2: view

Phenotypes for SDK2 Gene

GenomeRNAi human phenotypes for SDK2:
genes like me logo Genes that share phenotypes with SDK2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDK2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SDK2 Gene

Localization for SDK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDK2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SDK2 Gene COMPARTMENTS Subcellular localization image for SDK2 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SDK2: view

Pathways for SDK2 Gene

SuperPathways for SDK2 Gene

No Data Available

Interacting Proteins for SDK2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000376421 for SDK2 Gene via STRING

Gene Ontology (GO) - Biological Process for SDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SDK2: view

No data available for Pathways by source for SDK2 Gene

Transcripts for SDK2 Gene

Unigene Clusters for SDK2 Gene

Sidekick cell adhesion molecule 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDK2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDK2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP6: -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
SP1: -
SP3: - -

Relevant External Links for SDK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SDK2 Gene

mRNA expression in normal human tissues for SDK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDK2 Gene

This gene is overexpressed in Testis (8.4).

Protein differential expression in normal tissues for SDK2 Gene

This gene is overexpressed in CD4 Tcells (31.9), Ovary (15.2), and Testis (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SDK2 Gene

SOURCE GeneReport for Unigene cluster for SDK2 Gene Hs.435719

genes like me logo Genes that share expressions with SDK2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for SDK2 Gene

Orthologs for SDK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SDK2 35
  • 85.39 (n)
  • 87.59 (a)
SDK2 36
  • 87 (a)
(Canis familiaris)
Mammalia SDK2 35
  • 90.93 (n)
  • 95.59 (a)
SDK2 36
  • 93 (a)
(Mus musculus)
Mammalia Sdk2 35
  • 87.68 (n)
  • 94.75 (a)
Sdk2 16
Sdk2 36
  • 95 (a)
(Pan troglodytes)
Mammalia SDK2 35
  • 99.31 (n)
  • 99.72 (a)
SDK2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sdk2 35
  • 87.77 (n)
  • 95.08 (a)
(Monodelphis domestica)
Mammalia SDK2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia SDK2 36
  • 79 (a)
(Gallus gallus)
Aves SDK2 35
  • 82.33 (n)
  • 87.73 (a)
SDK2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia SDK2 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sdk2 35
  • 72.33 (n)
  • 79.43 (a)
(Danio rerio)
Actinopterygii sdk2b 35
  • 74.27 (n)
  • 81.04 (a)
SDK2 (2 of 2) 36
  • 78 (a)
sdk2b 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000659 35
  • 48.1 (n)
  • 40.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta sdk 35
  • 26.89 (n)
  • 7.8 (a)
Dscam 36
  • 17 (a)
Dscam2 36
  • 19 (a)
Dscam3 36
  • 17 (a)
Dscam4 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea rig-4 35
  • 39.61 (n)
  • 31.46 (a)
rig-4 36
  • 26 (a)
Species with no ortholog for SDK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SDK2 Gene

Gene Tree for SDK2 (if available)
Gene Tree for SDK2 (if available)

Paralogs for SDK2 Gene

Paralogs for SDK2 Gene

Selected SIMAP similar genes for SDK2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SDK2: view

Variants for SDK2 Gene

Sequence variations from dbSNP and Humsavar for SDK2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs689487 -- 73,600,009(+) GAACC(C/T)GTAGC intron-variant
rs715778 -- 73,607,307(-) ACTGG(C/T)TGATC intron-variant
rs748872 -- 73,524,098(-) GAAGT(A/G)GCCAG intron-variant
rs748873 -- 73,523,753(-) GGTTC(C/T)ATTTG intron-variant
rs748874 -- 73,523,721(-) actgg(C/G)tggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDK2 Gene

Variant ID Type Subtype PubMed ID
nsv833534 CNV Loss 17160897
nsv908735 CNV Loss 21882294
nsv908736 CNV Gain 21882294
nsv908737 CNV Loss 21882294
nsv457900 CNV Loss 19166990
esv2507814 CNV Deletion 19546169
esv2659285 CNV Deletion 23128226
esv2415749 CNV Deletion 18987734
esv2716195 CNV Deletion 23290073
dgv565e199 CNV Deletion 23128226
nsv513480 CNV Insertion 21212237
esv1445939 CNV Insertion 17803354
esv2716197 CNV Deletion 23290073
esv271862 CNV Insertion 20981092
esv2716198 CNV Deletion 23290073
nsv908738 CNV Loss 21882294
esv2716199 CNV Deletion 23290073
esv2716200 CNV Deletion 23290073
nsv908739 CNV Loss 21882294

Relevant External Links for SDK2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDK2 Gene

Disorders for SDK2 Gene

(1) University of Copenhagen DISEASES for SDK2 Gene

Relevant External Links for SDK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SDK2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SDK2 Gene

Publications for SDK2 Gene

  1. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. (PMID: 15213259) Kaufman L. … Klotman P.E. (J. Am. Soc. Nephrol. 2004) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina. (PMID: 12230981) Yamagata M. … Sanes J.R. (Cell 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SDK2 Gene

Sources for SDK2 Gene

Back to Top