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SDK2 Gene

protein-coding   GIFtS: 51
GCID: GC17M071330

Sidekick Cell Adhesion Molecule 2

(Previous name: sidekick homolog 2 (chicken))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sidekick Cell Adhesion Molecule 21 2
Sidekick Homolog 2 (Chicken)1
Protein Sidekick-22
Sidekick Homolog 22
KIAA15143

External Ids:    HGNC: 193081   Entrez Gene: 545492   Ensembl: ENSG000000691887   OMIM: 6072175   UniProtKB: Q58EX23   

Export aliases for SDK2 gene to outside databases

Previous GC identifers: GC17P071133 GC17M074374 GC17M071798 GC17M071930 GC17M068842 GC17M066739


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SDK2 Gene:
The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two
immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in
both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA,
heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila
sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for
alternative splicing at this gene locus has been observed but the full-length nature of additional variants has
not yet been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for SDK2 Gene:
SDK2 (sidekick cell adhesion molecule 2) is a protein-coding gene. An important paralog of this gene is FNDC3B.

UniProtKB/Swiss-Prot: SDK2_HUMAN, Q58EX2
Function: Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons (By
similarity)

Gene Wiki entry for SDK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SDK2 gene promoter:
         LHX3b/Lhx3b   AML1a   p53   Pax-5   Egr-1   POU3F2   S8   Pax-3   LHX3a/Lhx3a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSDK2 promoter sequence
   Search Chromatin IP Primers for SDK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SDK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q21.31

SDK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDK2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M071330:  view genomic region     (about GC identifiers)

Start:
71,330,523 bp from pter      End:
71,640,228 bp from pter
Size:
309,706 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SDK2_HUMAN, Q58EX2 (See protein sequence)
Recommended Name: Protein sidekick-2 precursor  
Size: 2172 amino acids; 239396 Da
Sequence caution: Sequence=BAA91841.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
4 PDB 3D structures from and Proteopedia for SDK2:
1WF5 (3D)        1WFN (3D)        1WFO (3D)        1WIS (3D)    
Secondary accessions: A6NMR8 C9JA57 Q86VY3 Q9NTD2 Q9NVB3 Q9P214
Alternative splicing: 4 isoforms:  Q58EX2-1   Q58EX2-2   Q58EX2-3   Q58EX2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SDK2: NX_Q58EX2

Explore proteomics data for SDK2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn193, Asn403, Asn609, Asn743, Asn936, Asn948, Asn1102, Asn1256, Asn1670
  • Modification sites at PhosphoSitePlus

  • See SDK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138424.1  
    ENSEMBL proteins: 
     ENSP00000376421   ENSP00000407098   ENSP00000373378  

    SDK2 Human Recombinant Protein Products:

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    OriGene Purified Protein for SDK2
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SDK2

     
    Search eBioscience for Proteins for SDK2 

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    Abcam antibodies for SDK2
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    SDK2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
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    Cloud-Clone Corp. CLIAs for SDK2
    Search eBioscience for ELISAs for SDK2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q58EX2

    ProtoNet protein and cluster: Q58EX2

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: SDK2_HUMAN, Q58EX2
    Similarity: Contains 13 fibronectin type-III domains
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with SDK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDK2_HUMAN, Q58EX2
    Function: Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SDK2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SDK2:
     Increased S DNA content, incre 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SDK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SDK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SDK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SDK2

    miRNA
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    Block miRNA regulation of human, mouse, rat SDK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SDK2 (see all 64):
    hsa-miR-411* hsa-miR-579 hsa-miR-576-3p hsa-miR-26a-2* hsa-miR-607 hsa-miR-3938 hsa-miR-328 hsa-miR-379*
    SwitchGear 3'UTR luciferase reporter plasmidSDK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SDK2
    Predesigned siRNA for gene silencing in human, mouse, rat SDK2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SDK2

    Clone
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    OriGene clones in human, mouse for SDK2 (see all 6)
    OriGene ORF clones in mouse, rat for SDK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SDK2 (NM_001144952)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDK2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SDK2_HUMAN, Q58EX2: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    peroxisome2
    extracellular1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SDK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SDK2
    Interactions:

        Search GeneGlobe Interaction Network for SDK2

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with SDK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SDK2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SDK2 gene (2 alternative transcripts): 
    NM_001144952.1  NM_019064.3  

    Unigene Cluster for SDK2:

    Sidekick cell adhesion molecule 2
    Hs.435719  [show with all ESTs]
    Unigene Representative Sequence: NM_001144952
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392650(uc002jjt.4 uc010dfm.3) ENST00000424778 ENST00000410094
    ENST00000479356(uc010dfn.2) ENST00000585283 ENST00000388726
    miRNA
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    Block miRNA regulation of human, mouse, rat SDK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SDK2 (see all 64):
    hsa-miR-411* hsa-miR-579 hsa-miR-576-3p hsa-miR-26a-2* hsa-miR-607 hsa-miR-3938 hsa-miR-328 hsa-miR-379*
    SwitchGear 3'UTR luciferase reporter plasmidSDK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SDK2
    Predesigned siRNA for gene silencing in human, mouse, rat SDK2
    Clone
    Products:
         
    OriGene clones in human, mouse for SDK2 (see all 6)
    OriGene ORF clones in mouse, rat for SDK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SDK2 (NM_001144952)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDK2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SDK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SDK2
      QuantiTect SYBR Green Assays in human, mouse, rat SDK2
      QuantiFast Probe-based Assays in human, mouse, rat SDK2

    Additional mRNA sequence: 

    AB040947.1 AK001694.1 AK021541.1 AK074994.1 AK091827.1 AL137357.1 BC045763.1 BC066363.1 

    10 DOTS entries:

    DT.95243605  DT.95264269  DT.40295317  DT.100020642  DT.92025571  DT.97809983  DT.100665601  DT.92444812 
    DT.91649038  DT.95085740 

    Selected AceView cDNA sequences (see all 73):

    CR616107 CD629651 AW662837 NM_019064 BM461616 AA906477 BU184456 AI222955 
    BM696523 AB040947 BX646558 AK001694 AI138884 AI365254 BX389359 BM693647 
    BX328916 CD629655 CF137270 CD629657 BC045763 AI150554 AA978208 BX093423 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SDK2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
    SP1:                                                                                                  -                                 
    SP2:                                                                                                                                    
    SP3:                                                        -                                         -                                 
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for SDK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SDK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAATCCTGA
    SDK2 Expression
    About this image


    SDK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             TGFbeta3+BMP7-induced chondrocytes
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Neural Tube (Nervous System)
             Metencephalon
    SDK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SDK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435719
        Custom PCR Arrays for SDK2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SDK2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sdk21 , 5 sidekick homolog 2 (chicken)1, 5 87.68(n)1
    94.75(a)1
      11 (79.30 cM)5
    2379791  NM_172800.21  NP_766388.21 
     1137763745 
    chicken
    (Gallus gallus)
    Aves SDK21 sidekick homolog 2 82.33(n)
    87.73(a)
      395215  NM_204538.1  NP_989869.1 
    lizard
    (Anolis carolinensis)
    Reptilia SDK26
    sidekick cell adhesion molecule 2
    88(a)
    1 ↔ 1
    2(96895912-96982778)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sdk21 sidekick cell adhesion molecule 2 72.33(n)
    79.43(a)
      100485585  XM_002937589.2  XP_002937635.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sdk2b1 sidekick homolog 2b (chicken) 74.27(n)
    81.04(a)
      564922  XM_688240.5  XP_693332.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta sdk1 sidekick 26.89(n)
    7.8(a)
      31017  NM_057942.4  NP_477290.6 
    worm
    (Caenorhabditis elegans)
    Secernentea rig-41 rig-4 39.61(n)
    31.46(a)
      177597  NM_068938.6  NP_501339.2 


    ENSEMBL Gene Tree for SDK2 (if available)
    TreeFam Gene Tree for SDK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SDK2 gene
    FNDC3B2  SDK12  DSCAM2  DSCAML12  FNDC3A2  
    5 SIMAP similar genes for SDK2 using alignment to 2 protein entries:     SDK2_HUMAN (see all proteins):
    SDK1    L1CAM    MUSK    PTPRS    KIAA0992

    Find genes that share paralogs with SDK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SDK2 (see all 7451)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504930461,2
    C--71330124(+) TCCCCA/GAGGGC 1 -- int10--------
    rs1383207821,2
    C--71330152(+) CCTGTC/TCCAGG 1 -- int10--------
    rs1845134071,2
    --71330176(+) ACTGTC/TGCAAA 1 -- int10--------
    rs1898217871,2
    --71330228(+) CTGGCA/GCAGAG 1 -- int10--------
    rs99127401,2
    C,F,A,H--71330478(+) CAGGTG/TACCCC 1 -- int130Minor allele frequency- N:0.00EA NA NS CSA WA 3330
    rs1813632581,2
    --71330513(+) ATGTTC/GCTTCA 1 -- int10--------
    rs1860245511,2
    --71330522(+) CAAATC/TTCCAA 1 -- spd10--------
    rs37643691,2
    H--71330608(-) TAAGAA/CAGAAA 1 -- ut314Minor allele frequency- C:0.00NS EA 418
    rs776785001,2
    C,F--71330664(+) AGATAT/CATATT 1 -- ut312Minor allele frequency- C:0.04NA 122
    rs37643681,2
    H--71330691(-) ATGGCA/CGGTGT 1 -- ut314Minor allele frequency- C:0.00NS EA 414

    HapMap Linkage Disequilibrium report for SDK2 (71330523 - 71580523 bp, first 250kb of SDK2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SDK2 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2415749CNV Deletion18987734
    esv2716200CNV Deletion23290073
    esv2716195CNV Deletion23290073
    esv2716197CNV Deletion23290073
    esv2659285CNV Deletion23128226
    esv2716199CNV Deletion23290073
    esv2507814CNV Deletion19546169
    dgv565e199CNV Deletion23128226
    esv2716198CNV Deletion23290073
    esv1445939CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SDK2
    DNA2.0 Custom Variant and Variant Library Synthesis for SDK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607217    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SDK2:
    Congenital stationary night blindness

    Find genes that share disorders with SDK2           About GenesLikeMe

    Genetic Association Database (GAD): SDK2
    Human Genome Epidemiology (HuGE) Navigator: SDK2 (1 document)

    Export disorders for SDK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SDK2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SDK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. (PubMed id 15213259)1, 3, 9 Kaufman L.... Klotman P.E. (J. Am. Soc. Nephrol. 2004)
    2. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (J. Hum. Genet. 2009)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina. (PubMed id 12230981)1, 3 Yamagata M....Sanes J.R. (Cell 2002)
    7. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 54549 HGNC: 19308 AceView: SDK2 Ensembl:ENSG00000069188 euGenes: HUgn54549
    ECgene: SDK2 H-InvDB: SDK2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1514

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SDK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SDK2 gene:
    Search GeneIP for patents involving SDK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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