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Aliases for SDK1 Gene

Aliases for SDK1 Gene

  • Sidekick Cell Adhesion Molecule 1 2 3
  • Sidekick Homolog 1, Cell Adhesion Molecule (Chicken) 2
  • Sidekick Homolog 1 (Chicken) 2

External Ids for SDK1 Gene

Previous GeneCards Identifiers for SDK1 Gene

  • GC07P003695
  • GC07P003712
  • GC07P003085
  • GC07P003114

Summaries for SDK1 Gene

GeneCards Summary for SDK1 Gene

SDK1 (Sidekick Cell Adhesion Molecule 1) is a Protein Coding gene. An important paralog of this gene is DSCAML1.

UniProtKB/Swiss-Prot for SDK1 Gene

  • Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons. Dysregulation of this protein may play an important role in podocyte dysfunction in HIV-associated nephropathy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDK1 Gene

Genomics for SDK1 Gene

Regulatory Elements for SDK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SDK1 Gene

Start:
3,301,448 bp from pter
End:
4,269,000 bp from pter
Size:
967,553 bases
Orientation:
Plus strand

Genomic View for SDK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SDK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SDK1 Gene

Proteins for SDK1 Gene

  • Protein details for SDK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5N4-SDK1_HUMAN
    Recommended name:
    Protein sidekick-1
    Protein Accession:
    Q7Z5N4
    Secondary Accessions:
    • Q8TEN9
    • Q8TEP5
    • Q96N44

    Protein attributes for SDK1 Gene

    Size:
    2213 amino acids
    Molecular mass:
    242112 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SDK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SDK1 Gene

Proteomics data for SDK1 Gene at MOPED

Post-translational modifications for SDK1 Gene

  • Glycosylation at Asn271, Asn301, Asn550, Asn563, Asn572, Asn655, Asn679, Asn782, Asn821, Asn882, Asn1015, Asn1024, Asn1282, Asn1333, Asn1654, Asn1748, Asn1767, Asn1819, and Asn1893
  • Modification sites at PhosphoSitePlus

Other Protein References for SDK1 Gene

No data available for DME Specific Peptides for SDK1 Gene

Domains for SDK1 Gene

Gene Families for SDK1 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Protein Domains for SDK1 Gene

Suggested Antigen Peptide Sequences for SDK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5N4

UniProtKB/Swiss-Prot:

SDK1_HUMAN :
  • Q7Z5N4
Domain:
  • Contains 13 fibronectin type-III domains.
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with SDK1: view

Function for SDK1 Gene

Molecular function for SDK1 Gene

UniProtKB/Swiss-Prot Function:
Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons. Dysregulation of this protein may play an important role in podocyte dysfunction in HIV-associated nephropathy.

Gene Ontology (GO) - Molecular Function for SDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SDK1: view

Phenotypes for SDK1 Gene

GenomeRNAi human phenotypes for SDK1:
genes like me logo Genes that share phenotypes with SDK1: view

Animal Model Products

miRNA for SDK1 Gene

miRTarBase miRNAs that target SDK1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SDK1 Gene

Localization for SDK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SDK1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SDK1 Gene COMPARTMENTS Subcellular localization image for SDK1 gene
Compartment Confidence
cytosol 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SDK1: view

Pathways for SDK1 Gene

SuperPathways for SDK1 Gene

No Data Available

Interacting Proteins for SDK1 Gene

Gene Ontology (GO) - Biological Process for SDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SDK1: view

No data available for Pathways by source for SDK1 Gene

Transcripts for SDK1 Gene

Unigene Clusters for SDK1 Gene

Sidekick cell adhesion molecule 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SDK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SDK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a ·
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:

ExUns: 47b ^ 48
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for SDK1 Gene

GeneLoc Exon Structure for
SDK1
ECgene alternative splicing isoforms for
SDK1

Expression for SDK1 Gene

mRNA expression in normal human tissues for SDK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SDK1 Gene

This gene is overexpressed in Artery - Tibial (4.7) and Pancreas (4.4).

Protein differential expression in normal tissues for SDK1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (29.6), Serum (12.4), Spleen (6.6), and Testis (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SDK1 Gene

SOURCE GeneReport for Unigene cluster for SDK1 Gene Hs.653013

mRNA Expression by UniProt/SwissProt for SDK1 Gene

Q7Z5N4-SDK1_HUMAN
Tissue specificity: Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells.
genes like me logo Genes that share expressions with SDK1: view

In Situ Assay Products

No data available for Expression partners for SDK1 Gene

Orthologs for SDK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SDK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SDK1 35
  • 84.66 (n)
  • 87.88 (a)
SDK1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SDK1 35
  • 86.67 (n)
  • 90.43 (a)
SDK1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sdk1 35
  • 84.91 (n)
  • 90.61 (a)
Sdk1 16
Sdk1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SDK1 35
  • 98.78 (n)
  • 99.28 (a)
SDK1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sdk1 35
  • 84.24 (n)
  • 90.33 (a)
oppossum
(Monodelphis domestica)
Mammalia SDK1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SDK1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SDK1 35
  • 76.73 (n)
  • 81.43 (a)
SDK1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SDK1 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sdk1a 35
  • 68.25 (n)
  • 68.65 (a)
sdk1a 36
  • 69 (a)
OneToMany
sdk1b 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dscam 36
  • 17 (a)
ManyToMany
Dscam2 36
  • 18 (a)
ManyToMany
Dscam3 36
  • 17 (a)
ManyToMany
Dscam4 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rig-4 36
  • 26 (a)
OneToMany
Species with no ortholog for SDK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SDK1 Gene

ENSEMBL:
Gene Tree for SDK1 (if available)
TreeFam:
Gene Tree for SDK1 (if available)

Paralogs for SDK1 Gene

Paralogs for SDK1 Gene

Selected SIMAP similar genes for SDK1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SDK1 Gene

genes like me logo Genes that share paralogs with SDK1: view

Variants for SDK1 Gene

Sequence variations from dbSNP and Humsavar for SDK1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs8514 -- 4,268,730(+) CTCCC(C/T)GTGGG reference, missense, utr-variant-3-prime
rs12631 -- 4,268,562(+) GCTCA(A/C)TCTGT intron-variant, utr-variant-3-prime
rs41869 -- 3,848,796(-) tactc(A/G)ggaag intron-variant
rs41870 -- 3,848,643(-) GAACG(C/T)GGCCT intron-variant
rs41871 -- 3,846,622(-) GGAGG(A/G)AGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SDK1 Gene

Variant ID Type Subtype PubMed ID
nsv887321 CNV Gain 21882294
nsv464264 CNV Loss 19166990
dgv2046e1 CNV Complex 17122850
nsv887324 CNV Loss 21882294
esv29028 CNV Loss 19812545
essv7993 CNV CNV 17122850
dgv7126n71 CNV Loss 21882294
dgv1180e199 CNV Deletion 23128226
esv2674504 CNV Deletion 23128226
nsv464268 CNV Gain 19166990
nsv519027 CNV Loss 19592680
nsv437530 CNV Loss 16327808
essv14000 CNV CNV 17122850
nsv8031 CNV Gain+Loss 18304495
nsv437980 CNV Loss 16468122
nsv887327 CNV Gain 21882294
nsv464269 CNV Loss 19166990
nsv524581 CNV Loss 19592680
nsv887328 CNV Loss 21882294
nsv510063 CNV Loss 20534489
nsv519151 CNV Loss 19592680
dgv7127n71 CNV Loss 21882294
esv2675206 CNV Deletion 23128226
nsv887331 CNV Loss 21882294
nsv442025 CNV CNV 18776908
dgv1087n67 CNV Gain 20364138
dgv2047e1 CNV Complex 17122850
nsv818473 CNV Gain 17921354
nsv528715 CNV Loss 19592680
nsv887332 CNV Loss 21882294
esv2733873 CNV Deletion 23290073
esv2589929 CNV Deletion 19546169
nsv887333 CNV Gain 21882294
nsv464270 CNV Loss 19166990
esv2733874 CNV Deletion 23290073
esv2320457 CNV Deletion 18987734
nsv366234 CNV Loss 16902084
nsv887334 CNV Loss 21882294
nsv464271 CNV Loss 19166990
esv1008693 CNV Insertion 20482838
esv1756780 CNV Insertion 17803354
nsv830888 CNV Gain 17160897
essv18811 CNV CNV 17122850
dgv2048e1 CNV Complex 17122850
dgv2049e1 CNV Complex 17122850
nsv517279 CNV Loss 19592680
nsv818474 CNV Loss 17921354
nsv442026 CNV CNV 18776908
nsv8032 CNV Gain 18304495
nsv821269 CNV Deletion 20802225
nsv819413 CNV Gain 19587683
esv2674935 CNV Deletion 23128226
esv26185 CNV Gain 19812545
nsv464273 CNV Loss 19166990
esv2668470 CNV Deletion 23128226
esv22623 CNV Loss 19812545
esv2733875 CNV Deletion 23290073
nsv887335 CNV Loss 21882294
esv2733876 CNV Deletion 23290073
nsv525399 CNV Loss 19592680
esv2666607 CNV Deletion 23128226
esv1562452 CNV Insertion 17803354
esv989356 CNV Insertion 20482838
esv29410 CNV Gain 19812545
esv2733877 CNV Deletion 23290073
esv2733878 CNV Deletion 23290073
esv2733879 CNV Deletion 23290073
esv2733880 CNV Deletion 23290073
esv2677474 CNV Deletion 23128226
esv2733881 CNV Deletion 23290073
esv1002214 CNV Deletion 20482838
nsv521103 CNV Gain 19592680
dgv7128n71 CNV Loss 21882294
nsv5621 CNV Insertion 18451855
esv272192 CNV Insertion 20981092
nsv519403 CNV Loss 19592680
nsv518377 CNV Loss 19592680
dgv797n27 CNV Gain 19166990
esv27140 CNV Loss 19812545
esv995938 CNV Gain 20482838
esv2733882 CNV Deletion 23290073
esv2733884 CNV Deletion 23290073
nsv509187 CNV Insertion 20534489
esv2430419 CNV Deletion 19546169
esv2004915 CNV Deletion 18987734
esv22966 CNV Loss 19812545
esv2733885 CNV Deletion 23290073
nsv5622 CNV Insertion 18451855
esv1006873 CNV Insertion 20482838
esv26943 CNV Gain 19812545
nsv820619 CNV Deletion 20802225
esv2323495 CNV Deletion 18987734
nsv511943 CNV Loss 21212237
nsv499704 CNV Gain 21111241
esv1551786 CNV Insertion 17803354
nsv527624 CNV Gain 19592680
nsv523815 CNV Gain 19592680
nsv887338 CNV Loss 21882294
esv25458 CNV Loss 19812545
esv2567177 CNV Deletion 19546169
esv2303183 CNV Deletion 18987734
esv4375 CNV Deletion 18987735
esv2733886 CNV Deletion 23290073
esv2657323 CNV Deletion 23128226
esv1005213 CNV Loss 20482838
nsv823988 CNV Loss 20364138
esv28341 CNV Loss 19812545
nsv518299 CNV Loss 19592680
esv1730974 CNV Insertion 17803354
esv2733887 CNV Deletion 23290073
nsv515665 CNV Loss 19592680
nsv820996 CNV Deletion 20802225
esv22195 CNV Gain 19812545
nsv823989 CNV Loss 20364138
esv2733888 CNV Deletion 23290073
dgv1181e199 CNV Deletion 23128226
dgv1088n67 CNV Gain 20364138
nsv887339 CNV Loss 21882294
esv2733889 CNV Deletion 23290073
dgv7129n71 CNV Loss 21882294
esv2733890 CNV Deletion 23290073
esv2733891 CNV Deletion 23290073
esv2733892 CNV Deletion 23290073
esv2733893 CNV Deletion 23290073
esv2733895 CNV Deletion 23290073
esv2652301 CNV Deletion 19546169
esv1559042 CNV Deletion 17803354
nsv887343 CNV Loss 21882294
esv2154358 CNV Deletion 18987734
esv2733896 CNV Deletion 23290073
nsv887344 CNV Gain 21882294
nsv518625 CNV Loss 19592680
esv2733897 CNV Deletion 23290073
esv2733898 CNV Deletion 23290073
esv2662079 CNV Deletion 23128226
nsv520034 CNV Loss 19592680
nsv887345 CNV Loss 21882294
nsv365802 CNV Insertion 16902084
nsv517001 CNV Loss 19592680
esv2664910 CNV Deletion 23128226
esv2733899 CNV Deletion 23290073
esv2742996 CNV Deletion 23290073
nsv366864 CNV Loss 16902084
esv2733900 CNV Deletion 23290073
dgv7130n71 CNV Gain 21882294
dgv7131n71 CNV Gain 21882294
nsv471260 CNV Gain 18288195
nsv464279 CNV Gain 19166990
nsv517675 CNV Gain+Loss 19592680
nsv5623 CNV Loss 18451855
dgv1089n67 CNV Loss 20364138
esv26074 CNV Loss 19812545
esv1201708 CNV Deletion 17803354

Relevant External Links for SDK1 Gene

HapMap Linkage Disequilibrium report
SDK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDK1 Gene

Disorders for SDK1 Gene

(1) University of Copenhagen DISEASES for SDK1 Gene

Relevant External Links for SDK1

Genetic Association Database (GAD)
SDK1
Human Genome Epidemiology (HuGE) Navigator
SDK1
genes like me logo Genes that share disorders with SDK1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SDK1 Gene

Publications for SDK1 Gene

  1. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. (PMID: 15213259) Kaufman L. … Klotman P.E. (J. Am. Soc. Nephrol. 2004) 2 3 4
  2. Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina. (PMID: 12230981) Yamagata M. … Sanes J.R. (Cell 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy. (PMID: 17307840) Kaufman L. … Klotman P.E. (FASEB J. 2007) 2 3
  5. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 48

Products for SDK1 Gene

Sources for SDK1 Gene

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