SDHD Gene

Aliases
for SDHD gene

Previous GC identifers: GC11P114310 GC11P113469 GC11P111495 GC11P111462 GC11P107881

Summaries
for SDHD gene

Genomic Views
for SDHD gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.1  NT_033899.8  

SwitchGear Promoter luciferase reporter plasmid: SDHD promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDHD

SDHD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P111991:  view genomic region     (about GC identifiers)

Proteins
for SDHD gene

Explore the universe of human proteins at neXtProt for SDHD: NX_O14521

SDHD Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SDHD OriGene Custom Protein Services for SDHD
	GenScript Custom Purified and Recombinant Proteins Services for SDHD
	Novus Biologicals SDHD Proteins Novus Biologicals SDHD Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SDHD

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SDHD
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SDHD
	GenScript Custom Superior Antibodies Services for SDHD
	Novus Biologicals SDHD Antibodies
	Search for Antibodies for SDHD at Abcam
	Uscn Antibodies for SDHD
	Search ThermoFisher Antibodies for SDHD

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SDHD
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SDHD

Protein Domains /
Families
for SDHD gene

ProtoNet protein and cluster: O14521

Function
for SDHD gene

miRNA Products:		OriGene 3'-UTR Clone: SDHD Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SDHD
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SDHD:
		hsa-miR-544 hsa-miR-204 hsa-miR-211
		SwitchGear 3'UTR luciferase reporter plasmid: SDHD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDHD (see all 7) OriGene shRNA RFP: SDHD OriGene siRNA: SDHD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDHD

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SDHD

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDHD (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDHD OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SDHD (NM_003002)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SDHD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDHD

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SDHD
		Search LifeMap BioReagents cell lines for SDHD

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDHD

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Sdhd)

Pathways & Interactions
for SDHD gene

	Super-pathway	contained gene-specific pathways
1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1.00 Oxidative phosphorylation 0.63 Respiratory electron transport 0.81 Parkinson's disease 0.61 Electron Transport Chain 0.76 Alzheimer's disease 0.43 The citric acid (TCA) cycle and respiratory electron transport 0.72 Huntington's disease 0.40
2	TCA Cycle	TCA Cycle 1.00 Pyruvate metabolism and Citric Acid (TCA) cycle 0.64 Citrate cycle (TCA cycle) 0.65
3	Metabolism	Metabolism 1.00 Metabolic pathways 0.38
4	TCA cycle II (eukaryotic)	TCA cycle II (eukaryotic) 1.00 Citric acid cycle (TCA cycle) 0.67

3 BioSystems Pathways for SDHD

	TCA Cycle
	Electron Transport Chain
	TCA cycle II (eukaryotic)

5/6        Reactome Pathways for SDHD

	Pyruvate metabolism and Citric Acid (TCA) cycle
	Respiratory electron transport
	Metabolism
	Citric acid cycle (TCA cycle)
	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

5/6         Kegg Pathways  (Kegg details for SDHD)

	Citrate cycle (TCA cycle)
	Oxidative phosphorylation
	Metabolic pathways
	Alzheimer's disease
	Parkinson's disease

SDHD for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SDHD

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/21 Interacting proteins for SDHD (O14521³ ENSP00000364699⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SDHD gene

Transcripts
for SDHD gene

Expression
for SDHD gene

SDHD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAAACT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDHD Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDHD
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDHD
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDHD

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDHD

Orthologs
for SDHD gene

Paralogs
for SDHD gene

Paralogs for SDHD gene

ENSG00000255292²  

SDHD for paralogs           About GeneDecksing


5/6 Pseudogenes.org Pseudogenes for SDHD (see all 6)
PGOHUM00000234863 PGOHUM00000240819 PGOHUM00000241031 PGOHUM00000258152 PGOHUM00000258163

Genomic Variants
for SDHD gene

10/295 NCBI SNPs in SDHD are shown (see all 295)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs803388471,2	C	pathogenic	125484354(+)	TGGGCC/TTTGCT	2	P L	mis1		0	--	--	--	--
rs1048943041,2	C	pathogenic	125484429(+)	TGACTA/GTGTTC	2	Y C	mis1		0	--	--	--	--
rs803388451,2	C	pathogenic	125490289(+)	CGATGG/TACTAT	2	D Y	mis1		0	--	--	--	--
rs803388441,2	C	pathogenic	125490321(+)	GCTTCC/TGGCTG	2	P L	mis1		0	--	--	--	--
rs112140771,2	C,F,	pathogenic	125491307(+)	CATACA/GCTTGT	4	H R	us2k1 mis1 ese3		8		EU NS NA	6335
rs1048943081,2	C	pathogenic	125491327(+)	GAATGA/GTGTGG	4	* W	us2k1 stg1		0	--	--	--	--
rs1048943031,2	C	pathogenic	125491350(+)	TTCTTC/TAGGAC	4	Q *	stg1 us2k1		0	--	--	--	--
rs1048943061,2	C	pathogenic	125491392(+)	TGCTTC/TGAACT	4	R *	us2k1 stg1		0	--	--	--	--
rs346775911,2	C,F,	pathogenic	125492319(+)	TTTGCG/AGTGCC	4	/S /G	us2k1 mis1		6		EU NA	6171
rs803388421,2	C	pathogenic	125492350(+)	GAGATC/GGCGGT	4	I M	mis1 us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SDHD (111957497 - 111990353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SDHD: --
Human Gene Mutation Database (HGMD): SDHD

Locus Specific Mutation Databases (LSDB): SDHD

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDHD

DNA2.0 Custom Variant and Variant Library Synthesis for SDHD

Disorders / Diseases
for SDHD gene

20/55 diseases for SDHD

10/28 Novoseek disease relationships for SDHD gene (see all 28)    About this table

Publications
for SDHD gene

PubMed articles for SDHD gene, integrated from 9 sources (see all 263) (see top 10): (articles sorted by number of sources associating them with SDHD)

Utopia: connect your pdf to the dynamic world of online information

1. Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. (PubMed id 15328326)^{1, 2, 4, 9} Neumann H.P.H.... Eng C. (2004)
2. Germ-line mutations in nonsyndromic pheochromocytoma. (PubMed id 12000816)^{1, 2, 4, 9} Neumann H.P.H.... Eng C. (2002)
3. Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23. (PubMed id 9533030)^{1, 2, 3} Hirawake H.... Kita K. (1997)
4. Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma. (PubMed id 11156372)^{1, 2, 9} Gimm O.... Eng C. (2000)
5. Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss. (PubMed id 11391796)^{1, 2, 9} Badenhop R.F....Schofield P.R. (2001)
6. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. (PubMed id 10657297)^{1, 2, 9} Baysal B.E.... Devlin B. (2000)
7. Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. (PubMed id 11897817)^{1, 4, 9} Baysal B.E.... Rubinstein W.S. (2002)
8. Germline SDHD mutation in paraganglioma of the spinal cord. (PubMed id 11526495)^{1, 2, 9} Masuoka J.... Ohgaki H. (2001)
9. Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene. (PubMed id 11391798)^{1, 2, 9} Taschner P.E.M.... Devilee P. (2001)
10. Characterization of the human SDHD gene encoding the small subunit of cytochrome b (cybS) in mitochondrial succinate-ubiquinone oxidoreductase. (PubMed id 10482792)^{1, 2, 9} Hirawake H.... Kita K. (1999)
11. Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas. (PubMed id 12007193)^{1, 2, 9} Kytoelae S.... Larsson C. (2002)
12. Novel mutations and the emergence of a common mutation in the SDHD gene causing familial paraganglioma. (PubMed id 11343322)^{1, 2, 9} Milunsky J.M.... Milunsky A. (2001)
13. Germline succinate dehydrogenase subunit D mutation segregating with familial non-RET C cell hyperplasia. (PubMed id 14557476)^{1, 4, 9} Lima J....Sobrinho-Simoes M. (2003)
14. SDHD mutation analysis in seven German patients with sporadic carotid body paraganglioma: one novel mutation, no Dutch founder mutation and further evidence that G12S is a polymorphism. (PubMed id 15032977)^{1, 2, 9} Leube B.... Royer-Pokora B. (2004)
15. Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes. (PubMed id 18678321)^{1, 2} Ni Y.... Eng C. (2008)
16. Familial gastrointestinal stromal tumors and germ-line mutations. (PubMed id 17804857)^{1, 2} McWhinney S.R....Stratakis C.A. (2007)
17. No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma. (PubMed id 16322339)^{1, 4} Montani M....Perren A. (2005)
18. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
19. Succinate dehydrogenase D variants do not constitute a risk factor for developing C cell hyperplasia or sporadic medullary thyroid carcinoma. (PubMed id 15623805)^{1, 4} Cascon A....Robledo M. (2005)
20. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
21. G12S and H50R variations are polymorphisms in the SDHD gene. (PubMed id 12696072)^{1, 2} Cascon A.... Robledo M. (2003)
22. A gene subject to genomic imprinting and responsible for hereditary paragangliomas maps to chromosome 11q23-qter. (PubMed id 1301144)^{1, 3} Heutink P....Oostra B.A. (1992)
23. Novel germline mutations in the SDHB and SDHD genes in Japanese pheochromocytomas. (PubMed id 17308434)^{1, 9} Isobe K....Takekoshi K. (2007)
24. Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer. (PubMed id 12883710)^{1, 9} Habano W....Horiuchi S. (2003)
25. Molecular characterization of novel germline deletion s affecting SDHD and SDHC in pheochromocytoma and paraganglioma patients. (PubMed id 19546167)^{1, 9} Bayley J.P....Vriends A.H. (2009)
26. Identification of a 4.9-kilo base-pair Alu-mediated f ounder SDHD deletion in two extended paraganglioma families from Austria. (PubMed id 20111059)^{1, 9} Janecke A.R....Baysal B.E. (2010)
27. Denaturing High Performance Liquid Chromatography Detection of SDHB, SDHD, and VHL Germline Mutations in Pheochromocytoma. (PubMed id 19215943)^{1, 9} Meyer-Rochow G.Y....Benn D.E. (2008)
28. Novel SDHD germ-line mutations in pheochromocytoma patients. (PubMed id 17576205)^{1, 9} Neumayer C....Haas O.A. (2007)
29. LOH on chromosome 11q, but not SDHD and Men1 mutations was frequently detectable in Chinese patients with pheochromocytoma and paraganglioma. (PubMed id 17526943)^{1, 9} Sun H.Y....Ning G. (2006)
30. Somatic loss of maternal chromosome 11 causes parent-of-origin-dependent inheritance in SDHD-linked paraganglioma and phaeochromocytoma families. (PubMed id 15064708)^{1, 9} Hensen E.F....Cornelisse C.J. (2004)
31. Large germline deletions of mitochondrial complex II subunits SDHB and SDHD in hereditary paraganglioma. (PubMed id 15531530)^{1, 9} McWhinney S.R....Eng C. (2004)
32. Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma. (PubMed id 17639058)^{1, 9} Korpershoek E....de Krijger R.R. (2007)
33. Germline SDHD mutation in familial phaeochromocytoma. (PubMed id 11323050)^{1, 9} Astuti D....Maher E.R. (2001)
34. Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas. (PubMed id 11397905)^{1, 9} Aguiar R.C....Dahia P.L. (2001)
35. Tumor risks and genotype-phenotype-proteotype analysi s in 358 patients with germline mutations in SDHB and SDHD. (PubMed id 19802898)^{1, 9} Ricketts C.J....Maher E.R. (2010)
36. Mutations associated with succinate dehydrogenase D-related malignant paragangliomas. (PubMed id 17973943)^{1, 9} Timmers H.J....Gimenez-Roqueplo A.P. (2008)
37. Chromosome 11 monosomy in conjunction with a mutated SDHD initiation codon in nonfamilial paraganglioma cases. (PubMed id 15066320)^{1, 9} Riemann K....Blin N. (2004)
38. The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. (PubMed id 11605159)^{1, 9} Gimenez-Roqueplo A.P....Jeunemaitre X. (2001)
39. Germinal mutations of RET, SDHB, SDHD, and VHL genes in patients with apparently sporadic pheochromocytomas and paragangliomas. (PubMed id 20205103)^{1, 9} Krawczyk A....Jarzab B. (2010)
40. Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes. (PubMed id 20236688)^{1, 9} Gill A.J....Clifton-Bligh R.J. (2010)
41. Rationalization of Genetic Testing in Patients with Apparently Sporadic Pheochromocytoma/Paraganglioma. (PubMed id 19343621)^{1, 9} CascA^n A....Robledo M. (2009)
42. Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior. (PubMed id 19075037)^{1, 9} Ghayee H.K....Auchus R.J. (2009)
43. A novel mutation in the SDHD gene responsible for familial paraganglioma. Medical and psychological implications. (PubMed id 19239085)^{1, 9} Prontera P....Donti E. (2008)
44. Cerebellopontine angle tumor in a patient with a maternally inherited SDHD gene mutation. (PubMed id 19205158)^{1, 9} Hartzell L.D....Dornhoffer J. (2008)
45. Analysis of SDHD and MMP12 in an affected solar keratosis and control cohort. (PubMed id 17727250)^{1, 9} Lintell N.A....McCabe M. (2007)
46. Genetic analyses of apparently sporadic pheochromocytomas: the Rotterdam experience. (PubMed id 17102080)^{1, 9} Korpershoek E....Dinjens W.N. (2006)
47. The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency. (PubMed id 16288654)^{7, 9} Bayley J.P....Taschner P.E. (2005)
48. Hereditary paraganglioma due to the SDHD M1I mutation in a second Chinese family: a founder effect? (PubMed id 12782822)^{1, 9} Lee S.C....Taschner P.E. (2003)
49. Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect. (PubMed id 12811540)^{1, 9} Astrom K....Baysal B.E. (2003)
50. Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomas. (PubMed id 19399650)^{1, 9} Waldmann J....Slater E.P. (2009)
51. Clinical predictors and algorithm for the genetic dia gnosis of pheochromocytoma patients. (PubMed id 19825962)^{1, 9} Erlic Z....Neumann H.P. (2009)
52. A role for succinate dehydrogenase genes in low chemo responsiveness to hypoxia? (PubMed id 19768395)^{1, 9} Richalet J.P....Elghozi J.L. (2009)
53. Diagnosis and management of hereditary paraganglioma syndrome due to the F933>X67 SDHD mutation. (PubMed id 19072999)^{1, 9} Marvin M.L....Gruber S.B. (2009)
54. W43X SDHD mutation in sporadic head and neck paraganglioma. (PubMed id 18561749)^{1, 9} Galera-Ruiz H....Galera-Davidson H. (2008)
55. Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD. (PubMed id 17667967)^{1, 9} Pasini B....Stratakis C.A. (2008)
56. High prevalence of SDHB mutations in head and neck paraganglioma in Belgium. (PubMed id 18551016)^{1, 9} Persu A....Vikkula M. (2008)
57. The genetics of paragangliomas: a review. (PubMed id 17298303)^{1, 9} Martin T.P....Maher E.R. (2007)
58. Malignant head and neck paragangliomas in SDHB mutation carriers. (PubMed id 17599579)^{1, 9} Boedeker C.C....Ridder G.J. (2007)
59. Malignant paragangliomas associated with mutations in the succinate dehydrogenase D gene. (PubMed id 17227803)^{1, 9} Havekes B....Romijn J.A. (2007)
60. Genetic testing in pheochromocytoma or functional paraganglioma. (PubMed id 16314641)^{1, 9} Amar L....Gimenez-Roqueplo A.P. (2005)
61. Multiple pheochromocytomas and paragangliomas in a young patient carrying a SDHD gene mutation. (PubMed id 15365827)^{1, 9} Novosel A....Schmidt H. (2004)
62. Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. (PubMed id 14500403)^{2, 9} Gimenez-Roqueplo A.-P....Jeunemaitre X. (2003)
63. The Dutch founder mutation SDHD.D92Y shows a reduced penetrance for the development of paragangliomas in a large multigenerational f amily. (PubMed id 19584903)^{1, 9} Hensen E.F....Devilee P. (2010)
64. Isocitrate dehydrogenase mutations are rare in pheoch romocytomas and paragangliomas. (PubMed id 19915015)^{1, 9} Gaal J....Dinjens W.N. (2010)
65. Genetics of pheochromocytoma and paraganglioma in Spanish patients. (PubMed id 19258401)^{1, 9} CascA^n A....Robledo M. (2009)
66. Chromosomal changes in sporadic and familial head and neck paragangliomas. (PubMed id 19393419)^{1, 9} Sevilla M.A....SuA!rez C. (2009)
67. Clinically guided genetic screening in a large cohort of italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas. (PubMed id 19223516)^{1, 9} Mannelli M....Opocher G. (2009)
68. Impact of screening kindreds for SDHD p.Cys11X as a common mutation associated with paraganglioma syndrome type 1. (PubMed id 18826997)^{1, 9} Peczkowska M....Neumann H.P. (2008)
69. Paraganglioma after maternal transmission of a succinate dehydrogenase gene mutation. (PubMed id 18211978)^{1, 9} Pigny P....Caron P. (2008)
70. Should genetic testing be performed in each patient with sporadic pheochromocytoma at presentation? (PubMed id 19029228)^{1, 9} Pigny P....Porchet N. (2008)
71. Germline SDHB mutations and familial renal cell carcinoma. (PubMed id 18728283)^{1, 9} Ricketts C....Maher E.R. (2008)
72. Single nucleotide polymorphisms in succinate dehydrogenase subunits and citrate synthase genes: association results for impaired spermatogenesis. (PubMed id 17298551)^{1, 9} Bonache S....Larriba S. (2007)
73. Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. (PubMed id 16405730)^{7, 9} Bayley J.P....Taschner P.E. (2006)
74. Crystal structure of mitochondrial respiratory membrane protein complex II. (PubMed id 15989954)^{7, 9} Sun F....Rao Z. (2005)
75. Mitochondrial complex II and genomic imprinting in inh eritance of paraganglioma tumors. (PubMed id 23291190)¹ Baysal B.E. (2013)
76. The endemic paraganglioma syndrome type 1: origin, spread, and clinical expression. (PubMed id 22456618)¹ Schiavi F....Opocher G. (2012)
77. Prevalence of germline mutations in patients with pheo chromocytoma or abdominal paraganglioma and sporadic presentation: a population- based study in Western Sweden. (PubMed id 22270996)¹ Muth A....Wangberg B. (2012)
78. Over-representation of the G12S polymorphism of the SD HD gene in patients with MEN2A syndrome. (PubMed id 22584711)¹ Lendvai N....Patocs A. (2012)
79. Common genetic mutations in the start codon of the SDH subunit D gene among Chinese families with familial head and neck paraganglioma s. (PubMed id 21945342)¹ Wang C.P....Lou P.J. (2012)
80. Succinate dehydrogenase (SDH) D subunit (SDHD) inactiv ation in a growth-hormone-producing pituitary tumor: a new association for SDH? (PubMed id 22170724)¹ Xekouki P....Stratakis C.A. (2012)
81. Somatic mutation analysis of the SDHB, SDHC, SDHD, and RET genes in the clinical assessment of sporadic and hereditary pheochromocytom a. (PubMed id 22573489)¹ Weber A....Erlic Z. (2012)
82. Prevalence and spectrum of SDHx mutations in pheochrom ocytoma and paraganglioma in patients from Belgium: an update. (PubMed id 22566194)¹ Persu A....Vikkula M. (2012)
83. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
84. Genomic imprinting at a boundary element flanking the SDHD locus. (PubMed id 21862453)¹ Baysal B.E....Shadel G.S. (2011)
85. Succinate dehydrogenase gene variants and their role i n Cowden syndrome. (PubMed id 21565294)¹ Bayley J.P. (2011)
86. Is the c.3G>C mutation in the succinate dehydrogen ase subunit D (SDHD) gene due to a founder effect in Chinese head and neck para ganglioma patients? (PubMed id 21792967)¹ Zha Y....Gao Z.Q. (2011)
87. A novel SDHD mutation associated with neck paraganglio ma. (PubMed id 21619495)¹ Reboll R....Basterra J. (2011)
88. Molecular analysis of pheochromocytoma after maternal transmission of SDHD mutation elucidates mechanism of parent-of-origin effect. (PubMed id 21937622)¹ Yeap P.M....Lindsay R.S. (2011)
89. Mutations in SDHD are the major determinants of the cl inical characteristics of Dutch head and neck paraganglioma patients. (PubMed id 21561462)¹ Hensen E.F....Vriends A.H. (2011)
90. Development and validation of a comprehensive mutatio n and deletion detection assay for SDHB, SDHC, and SDHD. (PubMed id 20153743)¹ Milosevic D....Grebe S.K. (2010)
91. Relevance of germline mutation screening in both fami lial and sporadic head and neck paraganglioma for early diagnosis and clinical management. (PubMed id 20208144)¹ Hermsen M.A....SuA!rez C. (2010)
92. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
93. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)¹ Prakash T....Taylor T.D. (2010)
94. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
95. Mutation analysis of the SDHB and SDHD genes in pheoc hromocytomas and paragangliomas: identification of a novel nonsense mutation (Q 168X) in the SDHB gene. (PubMed id 20505258)¹ Oishi Y....Shimizu C. (2010)
96. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
97. Pheochromocytomas and extra-adrenal paragangliomas de tected by screening in patients with SDHD-associated head-and-neck paragangliom as. (PubMed id 19289533)¹ Havekes B....Corssmit E.P. (2009)
98. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
99. Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene. (PubMed id 18840642)¹ Timmers H.J....Eisenhofer G. (2008)
100. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. (PubMed id 18987736)² Ley T.J.... Wilson R.K. (2008)
101. Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability. (PubMed id 17520677)⁷ Lehtonen H.J....Aaltonen L.A. (2007)
102. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
103. Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells. (PubMed id 16797480)¹ Selak M.A....Gottlieb E. (2006)
104. Fluorine-18 DOPA PET imaging of paraganglioma syndrom e. (PubMed id 16374125)⁷ Brink I....Neumann H.P. (2006)
105. Succinate dehydrogenase deficiency in human. (PubMed id 16143825)¹ Briere J.J....Rustin P. (2005)
106. A role for mitochondrial enzymes in inherited neoplasia and beyond. (PubMed id 12612654)¹ Eng C....Aaltonen L.A. (2003)
107. Frequent germ-line succinate dehydrogenase subunit D gene mutations in patients with apparently sporadic parasympathetic paraganglioma. (PubMed id 12114404)¹ Dannenberg H....de Krijger R.R. (2002)
108. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. (PubMed id 11827452)¹ Jia L....Francomano C.A. (2002)
109. Identification of novel SDHD mutations in patients with phaeochromocytoma and/or paraganglioma. (PubMed id 12111639)¹ Cascon A....Robledo M. (2002)
110. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
111. The Protein Data Bank. (PubMed id 10592235)⁷ Berman H.M....Bourne P.E. (2000)
112. In vitro kinetics of the rat brain succinate dehydrog enase inhibition by hexachlorophene. (PubMed id 10487417)⁷ Lokanatha V....Rajendra W. (1999)
113. Fine mapping of a putatively imprinted gene for familial non-chromaffin paragangliomas to chromosome 11q13.1: evidence for genetic heterogeneity. (PubMed id 7814027)¹ Mariman E.C....Ropers H.H. (1995)
114. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)¹ Adams M.D....White O. (1995)
115. Hereditary Paraganglioma -Pheochromocytoma Syndromes (PubMed id 20301715)¹ Kirmani S. and Young W.F. (1993)
116. Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria. (PubMed id 2302193)¹ Kita K.... Kasahara M. (1990)
117. No evidence for involvement of SDHD in neuroblastoma pathogenesis. (PubMed id 15331017)⁹ De Preter K....Speleman F. (2004)
118. Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility. (PubMed id 14974914)⁹ Astuti D.... Maher E.R. (2003)
119. Clinical characteristics of pheochromocytoma patients with germline mutations in SDHD. (PubMed id 15774781)⁹ Dannenberg H....Dinjens W.N. (2005)
120. A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. (PubMed id 11313745)⁹ Baysal B.E.... Devlin B. (2001)
121. Predominant expression of mutated allele of the succu nate dehydrogenase D (SDHD) gene in the SDHD-related paragangliomas. (PubMed id 19550080)⁹ Yamashita R....Kaise K. (2009)
122. A novel G106D alteration of the SDHD gene in a pedigree with familial paraganglioma. (PubMed id 17041923)⁹ Ogawa K....Horii A. (2006)
123. Mutation analysis of the SDHD gene in four kindreds with familial paraganglioma: description of one novel germline mutation. (PubMed id 15905695)⁹ Velasco A....Matias-Guiu X. (2005)
124. Phenotype variability of neural crest derived tumours in six Italian families segregating the same founder SDHD mutation Q109X. (PubMed id 16061558)⁹ Simi L....Mannelli M. (2005)
125. Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene. (PubMed id 16249420)⁹ Schiavi F....Neumann H.P. (2005)
126. SDHB, SDHC, and SDHD mutation screen in sporadic and familial head and neck paragangliomas. (PubMed id 15479192)⁹ Mhatre A.N....Lalwani A.K. (2004)
127. Genomic imprinting and environment in hereditary paraganglioma. (PubMed id 15264276)⁹ Baysal B.E. (2004)
128. Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients. (PubMed id 12386824)⁹ Perren A....Komminoth P. (2002)
129. The succinate dehydrogenase genetic testing in a larg e prospective series of patients with paragangliomas. (PubMed id 19454582)⁹ Burnichon N....Gimenez-Roqueplo A.P. (2009)
130. An immunohistochemical procedure to detect patients w ith paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. (PubMed id 19576851)⁹ van Nederveen F.H....Dinjens W.N. (2009)
131. Succinate dehydrogenase gene arrangement and expression in Anaplasma phagocytophilum. (PubMed id 18378408)⁹ Massung R.F....Lee K.N. (2008)
132. Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes. (PubMed id 16317055)⁹ Benn D.E....Robinson B.G. (2006)
133. Mutations of the SDHB and SDHD genes. (PubMed id 15883710)⁹ Pawlu C....Neumann H.P. (2005)
134. Cloning, mapping and association study with carcass traits of the porcine SDHD gene. (PubMed id 15932396)⁹ Zhu Z.M....Zhao S.H. (2005)
135. p53 alterations and their relationship to SDHD mutations in parasympathetic paragangliomas. (PubMed id 13679447)⁹ van Nederveen F.H....Dinjens W.N. (2003)
136. [Extraadrenal pheochromocytoma associated to SDHD gene mutation] (PubMed id 19318336)⁹ Lendvai N....PatA^cs A. (2009)
137. High frequency of germline succinate dehydrogenase mutations in sporadic cervical paragangliomas in northern Spain: mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlations. (PubMed id 17848412)⁹ Lima J....Garcia-Rostan G. (2007)
138. SDH mutations in patients affected by paraganglioma syndromes: a personal experience. (PubMed id 17102085)⁹ Mannelli M....Genuardi M. (2006)
139. Paraganglioma syndrome: SDHB, SDHC, and SDHD mutations in head and neck paragangliomas. (PubMed id 17102086)⁹ Schiavi F....Opocher G. (2006)
140. Carotid body paraganglioma and SDHD mutation in a Greek family. (PubMed id 16080474)⁹ Liapis C.D....Kostakis A. (2005)
141. Paragangliomas in patients with mutations of the SDHD gene. (PubMed id 15746863)⁹ Boedeker C.C....Schipper J. (2005)
142. Active succinate dehydrogenase (SDH) and lack of SDHD mutations in sporadic paragangliomas. (PubMed id 16080530)⁹ Braun S....Blin N. (2005)
143. The COPG2, DCN, and SDHD genes are biallelically expressed in cattle. (PubMed id 16151700)⁹ Khatib H. (2005)
144. A novel mutation in the SDHD gene in a family with inherited paragangliomas--implications of genetic diagnosis for follow up and treatment. (PubMed id 12509798)⁹ Renard L....Vikkula M. (2003)
145. [From gene to disease; from SDHD, a defect in the respiratory chain, to paragangliomas and pheochromocytomas] (PubMed id 12467161)⁹ Taschner P.E....van der Mey A.G. (2002)
146. Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. (PubMed id 19351833)⁹ Neumann H.P....Eng C. (2009)
147. Clinical features of paraganglioma syndromes. (PubMed id 19568339)⁹ Boedeker C.C....Schipper J. (2009)
148. Parasympathetic paragangliomas are part of the Von Hi ppel-Lindau syndrome. (PubMed id 19808854)⁹ Gaal J....de Krijger R.R. (2009)
149. Analysis of selected genes in neuroendocrine tumours: insulinomas and phaeochromocytomas. (PubMed id 18510707)⁹ Hrascan R....Karapandza N. (2008)
150. Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. (PubMed id 17967865)⁹ Guzy R.D....Schumacker P.T. (2008)
151. Genetics of carney triad: recurrent losses at chromosome 1 but lack of germline mutations in genes associated with paragangliomas and gastrointestinal stromal tumors. (PubMed id 17535989)⁹ Matyakhina L....Stratakis C.A. (2007)
152. Expression of mRNAs for succinate dehydrogenase subunits and related genes in pheochromocytoma. (PubMed id 17102093)⁹ Isobe K....Kawakami Y. (2006)
153. Von Hippel-Lindau disease and endocrine tumour susceptibility. (PubMed id 16728571)⁹ Woodward E.R. and Maher E.R. (2006)
154. Genetic and clinical investigation of pheochromocytoma: a 22-year experience, from Freiburg, Germany to international effort. (PubMed id 17102079)⁹ Bausch B....Neumann H.P. (2006)
155. Risk-oriented approach to hereditary adrenal pheochromocytoma. (PubMed id 17102110)⁹ Machens A....Dralle H. (2006)
156. Review: Should patients with apparently sporadic pheochromocytomas or paragangliomas be screened for hereditary syndromes? (PubMed id 16735498)⁹ Jimenez C....Gagel R.F. (2006)
157. Comprehensive mutation scanning of NF1 in apparently sporadic cases of pheochromocytoma. (PubMed id 16787982)⁹ Bausch B....Neumann H.P. (2006)
158. Pheochromocytoma-associated syndromes: genes, proteins and functions of RET, VHL and SDHx. (PubMed id 15883706)⁹ Gimm O. (2005)
159. SDHC mutations in hereditary paraganglioma/pheochromocytoma. (PubMed id 15883704)⁹ Muller U....Niemann S. (2005)
160. Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas. (PubMed id 12618761)⁹ Benn D.E.... Robinson B.G. (2003)
161. Phenotypic dichotomy in mitochondrial complex II genetic disorders. (PubMed id 11692162)⁹ Baysal B.E....Taschner P.E. (2001)
162. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. (PubMed id 11404820)⁹ Astuti D.... Maher E.R. (2001)
163. Multiple losses and transfers to the nucleus of two mitochondrial succinate dehydrogenase genes during angiosperm evolution. (PubMed id 11454775)⁹ Adams K.L....Palmer J.D. (2001)
164. SDHAF2 mutations in familial and sporadic paraganglio ma and phaeochromocytoma. (PubMed id 20071235)⁹ Bayley J.P....Robledo M. (2010)
165. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gas tric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clini cal implications. (PubMed id 19522824)⁹ Stratakis C.A. and Carney J.A. (2009)
166. Sdhd and SDHD/H19 knockout mice do not develop paraga nglioma or pheochromocytoma. (PubMed id 19956719)⁹ Bayley J.P....Taschner P.E. (2009)
167. Similar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas suggest a common pathway to tumorigenesis. (PubMed id 19432956)⁹ Hensen E.F....Cornelisse C.J. (2009)
168. Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas. (PubMed id 17102089)⁹ Dahia P.L. (2006)
169. Familial nonsyndromic pheochromocytoma. (PubMed id 17102081)⁹ Opocher G....Mantero F. (2006)
170. Frequent genetic changes in childhood pheochromocytomas. (PubMed id 17102083)⁹ De Krijger R.R....Dinjens W.N. (2006)
171. Multiparameter DNA flow-sorting demonstrates diploidy and SDHD wild-type gene retention in the sustentacular cell compartment of head and neck paragangliomas: chief cells are the only neoplastic component. (PubMed id 15095273)⁹ Douwes Dekker P.B....Cornelisse C.J. (2004)
172. The genetic basis of pheochromocytoma. (PubMed id 14674304)⁹ Gimm O....Neumann H.P. (2004)
173. SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology. (PubMed id 14595761)⁹ Douwes Dekker P.B....Cornelisse C.J. (2003)
174. The pressure rises: update on the genetics of phaeochromocytoma. (PubMed id 12351569)⁹ Maher E.R. and Eng C. (2002)
175. Cytopathies involving mitochondrial complex II. (PubMed id 12231007)⁹ Ackrell B.A. (2002)
176. (PubMed id 17928783)⁹ 
177. Mutations of the metabolic genes IDH1, IDH2, and SDHA F2 are not major determinants of the pseudohypoxic phenotype of sporadic pheoch romocytomas and paragangliomas. (PubMed id 20130071)⁹ Yao L....Dahia P.L. (2010)
178. Phaeochromocytoma: state-of-the-art. (PubMed id 20514823)⁹ Donckier J.E. and Michel L. (2010)
179. SDHD-related chromaffin tumours: disease localisation to genetic dysfunction. (PubMed id 20190551)⁹ Srirangalingam U....Drake W.M. (2010)
180. Paraganglioma syndrome type 1 in a patient with Carne y-Stratakis syndrome. (PubMed id 20098451)⁹ Ayala-Ramirez M....Jimenez C. (2010)
181. A large deletion in the succinate dehydrogenase B gen e (SDHB) in a Japanese patient with abdominal paraganglioma and concomitant met astasis. (PubMed id 20379037)⁹ Kodama H....Takekoshi K. (2010)
182. Malignant extra-adrenal pheochromocytoma caused by an SDHB intronic variation leading to a 54-bp deletion in exon 4. (PubMed id 19411806)⁹ Ercolino T....Bernini G.P. (2009)
183. [Research advances in molecular biology of carotid body tumor.] (PubMed id 19418004)⁹ Zhou Q. and Zheng J.W. (2009)
184. Novel mutation (L157X) in the succinate dehydrogenase B gene (SDHB) in a Japanese family with abdominal paraganglioma following lung metastasis. (PubMed id 19261994)⁹ Saito T....Takekoshi K. (2009)
185. Familial pheochromocytoma. (PubMed id 19269919)⁹ Erlic Z. and Neumann H.P. (2009)
186. SDH mutations in tumorigenesis and inherited endocrin e tumours: lesson from the phaeochromocytoma-paraganglioma syndromes. (PubMed id 19522823)⁹ Pasini B. and Stratakis C.A. (2009)
187. Carney triad in an adult with aggressive behavior: th e first case in Korea. (PubMed id 19881977)⁹ Song H.J....Park C.K. (2009)
188. Local-regional recurrence of sporadic or syndromic ab dominal extra-adrenal paraganglioma: incidence, characteristics, and outcome. (PubMed id 19958924)⁹ Van Slycke S....Pattou F. (2009)
189. Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature aging. (PubMed id 19233206)⁹ Huang J. and Lemire B.D. (2009)
190. No evidence for promoter region methylation of the su ccinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer. (PubMed id 19778456)⁹ Huang K.T....Fox S.B. (2009)
191. Multiple endocrine neoplasias: advances and challenge s for the future. (PubMed id 19522821)⁹ Alevizaki M. and Stratakis C.A. (2009)
192. Pigmented 'black' cardiac paraganglioma in a patient with a novel germ-line SDHD mutation. (PubMed id 19027316)⁹ Petramala L....Letizia C. (2009)
193. Rare presentation of familial paraganglioma without evidence of mutation in the SDH, RET and VHL genes: towards further genetic heterogeneity. (PubMed id 19145771)⁹ Persu A....Vikkula M. (2009)
194. [Pheochromocytoma: diagnosis and treatment] (PubMed id 19899721)⁹ WidimskA1 J....Holaj R. (2009)
195. The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients. (PubMed id 19368708)⁹ Bayley J.P....Weiss M.M. (2009)
196. Screening for familial paragangliomas. (PubMed id 17936061)⁹ Myssiorek D....Rinaldo A. (2008)
197. Sporadic paraganglioma. (PubMed id 18224469)⁹ Lee J.A. and Duh Q.Y. (2008)
198. [Achievements of the COMETE program in the genetics of pheochromocytoma] (PubMed id 18663985)⁹ Gimenez-Roqueplo A.P....Plouin P.F. (2008)
199. [The sympathetic system and neuroendocrine hypertension] (PubMed id 18350500)⁹ Zuccala' A....Rapana' R. (2008)
200. Cells silenced for SDHB expression display characteristic features of the tumor phenotype. (PubMed id 18519664)⁹ Cervera A.M....McCreath K.J. (2008)
201. SDHC mutation in an elderly patient without familial antecedents. (PubMed id 18681855)⁹ Lopez-Jimenez E....Cascon A. (2008)
202. Uncommon clinical presentations of pheochromocytoma and paraganglioma in two different patients affected by two distinct novel VHL germline mutations. (PubMed id 18031321)⁹ Ercolino T....Mannelli M. (2008)
203. Cervical paragangliomas: is SDH genetic analysis systematically required? (PubMed id 17987308)⁹ Fakhry N....Zanaret M. (2008)
204. Malignant paraganglioma caused by a novel germline mutation of the succinate dehydrogenase D-gene--a case report. (PubMed id 18213727)⁹ Papaspyrou K....Helling K. (2008)
205. Recent advances in the genetics of phaeochromocytoma and functional paraganglioma. (PubMed id 18307724)⁹ Gimenez-Roqueplo A.P....Plouin P.F. (2008)
206. R46Q mutation in the succinate dehydrogenase B gene (SDHB) in a Japanese family with both abdominal and thoracic paraganglioma following metastasis. (PubMed id 18362451)⁹ Takekoshi K....Yamada N. (2008)
207. Systematic screening and treatment evaluation of here ditary neck paragangliomas. (PubMed id 17563904)⁹ Fish J.H....Fraedrich G. (2007)
208. Germline mutations in PTEN and SDHC in a woman with epithelial thyroid cancer and carotid paraganglioma. (PubMed id 17898811)⁹ Zbuk K.M....Eng C. (2007)
209. Ubiquinone-binding site mutations in the Saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinate. (PubMed id 17636259)⁹ Szeto S.S....Lemire B.D. (2007)
210. A Chinese family with familial paraganglioma syndrome due to succinate dehydrogenase deficiency. (PubMed id 17406045)⁹ Ma R.C....Cockram C.S. (2007)
211. Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA. (PubMed id 17376234)⁹ Baysal B.E....Ferrell R.E. (2007)
212. Pheochromocytoma: an update on genetics and management. (PubMed id 18045948)⁹ Karagiannis A....Harsoulis F. (2007)
213. A recurrent stop-codon mutation in succinate dehydrogenase subunit B gene in normal peripheral blood and childhood T-cell acute leukemia. (PubMed id 17487275)⁹ Baysal B.E. (2007)
214. [Diagnostic and therapeutic procedures in pheochromocytoma: current trends] (PubMed id 17578179)⁹ WidimskA1 J....Holaj R. (2007)
215. Asymptomatic bilateral adrenal pheochromocytoma in a patient with a germline V804M mutation in the RET proto-oncogene. (PubMed id 17466010)⁹ Recasens M....Ricart W. (2007)
216. [Head and neck paragangliomas: revision of 89 cases in 73 patients] (PubMed id 17371691)⁹ Sevilla GarcA-a M.A....SuA!rez Nieto C. (2007)
217. Novel NF1 gene mutation in a Japanese patient with neurofibromatosis type 1 and a gastrointestinal stromal tumor. (PubMed id 16741618)⁹ Nemoto H....Sanada Y. (2006)
218. Genetic testing in pheochromocytoma: increasing importance for clinical decision making. (PubMed id 17102076)⁹ Bornstein S.R. and Gimenez-Roqueplo A.P. (2006)
219. An apparently sporadic paraganglioma with an SDHB gene germline mutation presenting at age 68 years. (PubMed id 16472267)⁹ Elston M.S....Conaglen J.V. (2006)
220. Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations. (PubMed id 16954163)⁹ Pollard P.J....Maher E.R. (2006)
221. Tumours of familial origin in the head and neck. (PubMed id 16857415)⁹ Suarez C....Rinaldo A. (2006)
222. The malignant potential of a succinate dehydrogenase subunit B germline mutation. (PubMed id 16699302)⁹ Fuentes C....Neumann H.P. (2006)
223. [Hereditary paragangliomas and pheochromocytomas] (PubMed id 17373214)⁹ Gimenez-Roqueplo A.P. (2006)
224. Functioning paraganglioma and gastrointestinal stromal tumor of the jejunum in three women: syndrome or coincidence. (PubMed id 16330941)⁹ Perry C.G....Carney J.A. (2006)
225. Recent advances in the diagnosis and treatment of pheochromocytoma. (PubMed id 17119341)⁹ WidimskA1 J. (2006)
226. Characteristic genomic imbalances in pediatric pheochromocytoma. (PubMed id 16518846)⁹ Hering A....Loncarevic I. (2006)
227. Genetic testing in pheochromocytoma- and paraganglioma-associated syndromes. (PubMed id 17102077)⁹ Benn D.E....Robinson B.G. (2006)
228. Gross SDHB deletions in patients with paraganglioma detected by multiplex PCR: a possible hot spot? (PubMed id 16258955)⁹ Cascon A....Robledo M. (2006)
229. Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas. (PubMed id 15788647)⁹ Margetts C.D....Maher E.R. (2005)
230. cDNA microarray analysis assists in diagnosis of malignant intrarenal pheochromocytoma originally masquerading as a renal cell carcinoma. (PubMed id 16061554)⁹ Takahashi M....Kanayama H.O. (2005)
231. New genetic causes of pheochromocytoma: current concepts and the clinical relevance. (PubMed id 15832076)⁹ Neumann H.P....Murai M. (2005)
232. A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. (PubMed id 16103922)⁹ Dahia P.L....Stiles C.D. (2005)
233. A common pathway for genetic events leading to pheochromocytoma. (PubMed id 16098460)⁹ Maxwell P.H. (2005)
234. [Genetics of endocrine tumours] (PubMed id 16735973)⁹ Calender A....Zhang C.X. (2005)
235. Pheochromocytoma in von Hippel-Lindau disease and neurofibromatosis type 1. (PubMed id 15883705)⁹ Opocher G....Mantero F. (2005)
236. Mitochondrial tumour suppressors: a genetic and biochemical update. (PubMed id 16327764)⁹ Gottlieb E. and Tomlinson I.P. (2005)
237. Increased prevalence of catecholamine excess and phaeochromocytomas in a well-defined Dutch population with SDHD-linked head and neck paragangliomas. (PubMed id 15762191)⁹ van Houtum W.H....Romijn J.A. (2005)
238. Pheochromocytoma and functional paraganglioma syndrome: no longer the 10% tumor. (PubMed id 15719371)⁹ Elder E.E....Larsson C. (2005)
239. New insights in the genetics of adrenocortical tumors, pheochromocytomas and paragangliomas. (PubMed id 16001332)⁹ Bertherat J. and Gimenez-Roqueplo A.P. (2005)
240. Flutolanil and carboxin resistance in Coprinus cinereus conferred by a mutation in the cytochrome b560 subunit of succinate dehydrogenase complex (Complex II). (PubMed id 15365819)⁹ Ito Y....Yanagi S.O. (2004)
241. Carotid body tumors in humans caused by a mutation in the gene for succinate dehydrogenase D (SDHD). (PubMed id 15602946)⁹ Dahan A....Cornelisse C.J. (2004)
242. K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma. (PubMed id 15473885)⁹ McDonnell C.M....Zacharin M.R. (2004)
243. Familial paraganglioma: a novel presentation of a case and response to therapy with radiolabelled MIBG. (PubMed id 16982587)⁹ Lawrence J.K....Grossman A.B. (2004)
244. The prevalence of SDHB, SDHC, and SDHD mutations in patients with head and neck paraganglioma and association of mutations with clinical features. (PubMed id 15235042)⁹ Badenhop R.F....Schofield P.R. (2004)
245. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. (PubMed id 14685938)⁹ Vanharanta S....Eng C. (2004)
246. [Paraganglioma in the area of the head and neck. A review of molecular genetic research] (PubMed id 14740109)⁹ Braun S....Kupka S. (2004)
247. On the association of succinate dehydrogenase mutations with hereditary paraganglioma. (PubMed id 14643060)⁹ Baysal B.E. (2003)
248. Alterations of the SDHD gene locus in midgut carcinoids. (PubMed id 12619155)⁹ Lima J....Sobrinho-Simoes M. (2003)
249. The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction. (PubMed id 12925748)⁹ Albayrak T....Grimm S. (2003)
250. Fine analysis of the short arm of chromosome 1 in sporadic and familial pheochromocytoma. (PubMed id 14974911)⁹ Opocher G....Mostacciuolo M.L. (2003)
251. Intronic single nucleotide polymorphisms in the RET protooncogene are associated with a subset of apparently sporadic pheochromocytoma and may modulate age of onset. (PubMed id 14557473)⁹ McWhinney S.R....Eng C. (2003)
252. 18F-DOPA positron emission tomography for the detection of glomus tumours. (PubMed id 12618904)⁹ Hoegerle S....Neumann H.P. (2003)
253. Pheochromocytoma: the expanding genetic differential diagnosis. (PubMed id 12928344)⁹ Bryant J....Nathanson K.L. (2003)
254. Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. (PubMed id 12213855)⁹ Young A.L.... Young W.F. Jr. (2002)
255. Etiopathogenesis and clinical presentation of carotid body tumors. (PubMed id 12384970)⁹ Baysal B.E. and Myers E.N. (2002)
256. Absence of SDHD mutations in primary nasopharyngeal carcinomas. (PubMed id 11857371)⁹ Hui A.B....Huang D.P. (2002)

External Searches for SDHD gene

Genome Databases showing SDHD gene

Other Databases showing SDHD gene

Specialized Databases showing SDHD gene

Products
for SDHD gene