Aliases for SDHD Gene
Aliases for SDHD Gene
External Ids for SDHD Gene
- HGNC: 10683
- Entrez Gene: 6392
- Ensembl: ENSG00000204370
- OMIM: 602690
- UniProtKB: O14521
Previous HGNC Symbols for SDHD Gene
- PGL
- PGL1
Previous GeneCards Identifiers for SDHD Gene
- GC11P114310
- GC11P113469
- GC11P111991
- GC11P111495
- GC11P111462
- GC11P107881
Summaries for SDHD Gene
-
This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
GeneCards Summary for SDHD Gene
SDHD (Succinate Dehydrogenase Complex Subunit D) is a Protein Coding gene. Diseases associated with SDHD include Paragangliomas 1, With Or Without Deafness and Cowden Syndrome 3. Among its related pathways are Metabolism and Citrate cycle (TCA cycle). GO annotations related to this gene include heme binding and ubiquinone binding. An important paralog of this gene is ENSG00000255292.
UniProtKB/Swiss-Prot for SDHD Gene
-
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SDHD Gene
Genomics for SDHD Gene
Regulatory Elements for SDHD Gene
Enhancers for SDHD Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SDHD on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SDHD gene promoter:
Regulatory Element Products
Genomic Location for SDHD Gene
- Chromosome:
- 11
- Start:
- 112,086,773 bp from pter
- End:
- 112,120,013 bp from pter
- Size:
- 33,241 bases
- Orientation:
- Plus strand
Genomic View for SDHD Gene
Genes around SDHD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.1 by Ensembl
- 11q23.1 by Entrez Gene
- 11q23 by HGNC
SDHD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SDHD Gene
Proteins for SDHD Gene
-
Protein details for SDHD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14521-DHSD_HUMAN
- Recommended name:
- Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
- Protein Accession:
- O14521
- A6ND90
- B3KQQ8
- E9PIC0
- E9PIG3
- E9PQI9
- Q53XW5
- Q6IRW2
Protein attributes for SDHD Gene
- Size:
- 159 amino acids
- Molecular mass:
- 17043 Da
- Quaternary structure:
-
- Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
Protein Expression for SDHD Gene
Post-translational modifications for SDHD Gene
No Post-translational modifications
Other Protein References for SDHD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for SDHD
-
Custom Antibody ServicesOriGene Antibodies for SDHD
- Novus Biologicals Antibodies for SDHD
-
Abcam antibodies for SDHD
- Invitrogen Antibodies for SDHD
- antibodies-online Antibodies for SDHD: See all 34
- GeneTex SDHD antibody for SDHD
-
Custom Antibody ServicesProSci Antibodies for SDHD
-
Santa Cruz Biotechnology (SCBT) Antibodies for SDHD
Protein Products
-
OriGene Purified Proteins for SDHD
- Search Origene for MassSpec and Protein Over-expression Lysates for SDHD
- Origene Custom Protein Services for SDHD
- antibodies-online Proteins for SDHD: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SDHD
-
Abcam proteins for SDHD
Assay Products
- antibodies-online Kits for SDHD: See all 6
No data available for DME Specific Peptides for SDHD Gene
Domains & Families for SDHD Gene
Gene Families for SDHD Gene
Suggested Antigen Peptide Sequences for SDHD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14521- Family:
-
- Belongs to the CybS family.
Function for SDHD Gene
Molecular function for SDHD Gene
- GENATLAS Biochemistry:
- succinate dehydrogenase,cyb S subunit,liver,inner mitochondrial membrane,component 4 of complex II of mitochondrial respiratory chain (CII-4),oxidative phosphorylation,(OXPHOS),also catalyzing the seventh step of the citric acid cycle
- UniProtKB/Swiss-Prot Function:
- Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000104 | succinate dehydrogenase activity | IDA | 9533030 |
| GO:0008177 | contributes_to succinate dehydrogenase (ubiquinone) activity | IBA | -- |
| GO:0009055 | electron carrier activity | TAS | 9533030 |
| GO:0020037 | heme binding | ISS | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for SDHD Gene
- MGI mutant phenotypes for SDHD:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for SDHD:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SDHD
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SDHD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SDHD gene
- Search ViGene Biosciences for SDHD
CRISPR Products
-
OriGene CRISPR knockouts for SDHD
- GenScript: Design CRISPR guide RNA sequences for SDHD
miRNA for SDHD Gene
- miRTarBase miRNAs that target SDHD
-
- hsa-mir-210-3p (MIRT054099)
- hsa-mir-147b (MIRT054218)
- hsa-mir-5096 (MIRT468702)
- hsa-mir-1303 (MIRT468703)
- hsa-mir-4289 (MIRT468704)
- hsa-mir-1250-3p (MIRT468705)
- hsa-mir-23a-3p (MIRT468706)
- hsa-mir-23c (MIRT468707)
- hsa-mir-23b-3p (MIRT468708)
- hsa-mir-130a-5p (MIRT468709)
- hsa-mir-6875-3p (MIRT543314)
- hsa-mir-384 (MIRT543315)
- hsa-mir-5571-3p (MIRT543316)
- hsa-mir-7975 (MIRT543317)
- hsa-mir-374b-5p (MIRT543318)
- hsa-mir-374a-5p (MIRT543319)
- hsa-mir-610 (MIRT543320)
- hsa-mir-556-5p (MIRT543321)
- hsa-mir-5692c (MIRT543322)
- hsa-mir-5692b (MIRT543323)
- hsa-mir-369-3p (MIRT543324)
- hsa-mir-3159 (MIRT543325)
- hsa-mir-5680 (MIRT543326)
- hsa-mir-5583-3p (MIRT543327)
- hsa-mir-4517 (MIRT543328)
- hsa-mir-6083 (MIRT699808)
- hsa-mir-4752 (MIRT699809)
- hsa-mir-6833-5p (MIRT699810)
- hsa-mir-4800-5p (MIRT699811)
- hsa-mir-3138 (MIRT699812)
miRNA Products
- Search ViGene Biosciences for SDHD
Clone Products
- Sino Biological Human cDNA Clone for SDHD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SDHD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SDHD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SDHD gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SDHD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SDHD gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12218) for SDHD
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SDHD Gene
Localization for SDHD Gene
Subcellular locations from UniProtKB/Swiss-Prot for SDHD Gene
- Mitochondrion inner membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| nucleus | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA,TAS | 2302193 |
| GO:0005740 | mitochondrial envelope | IEA,TAS | 9533030 |
| GO:0005743 | mitochondrial inner membrane | ISS,TAS | -- |
| GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for SDHD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
| 2 | Citrate cycle (TCA cycle) |
.01
|
|
| 3 | Pyruvate metabolism and Citric Acid (TCA) cycle |
.01
|
|
| 4 | Metabolism |
.37
|
|
| 5 | Carbon metabolism | ||
Pathways by source for SDHD Gene
4 BioSystems pathways for SDHD Gene
8 KEGG pathways for SDHD Gene
UniProtKB/Swiss-Prot O14521-DHSD_HUMAN
- Pathway: Carbohydrate metabolism; tricarboxylic acid cycle.
Interacting Proteins for SDHD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006099 | tricarboxylic acid cycle | IEA,TAS | -- |
| GO:0006121 | mitochondrial electron transport, succinate to ubiquinone | IBA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for SDHD Gene
Drugs & Compounds for SDHD Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Hexachlorophene | Approved, Withdrawn | Pharma | Target, inhibitor | 3 | ||
| Succinic acid | Approved | Nutra | Full agonist, Agonist, Target | 0 | ||
| FAD | Approved | Pharma | 0 | |||
| Ubiquinone-1 | Experimental | Pharma | Target | 0 | ||
| SB-649868 | Experimental | Pharma | Antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Fe2+ |
|
15438-31-0 |
|
|||
| QH2 |
|
56275-39-9 |
|
|||
| Sulfide |
|
18496-25-8 |
|
(1) ApexBio Compounds for SDHD Gene
| Compound | Action | Cas Number |
|---|---|---|
| Methylmalonate | 516-05-2 |
Drug Products
- ApexBio compounds for SDHD
Transcripts for SDHD Gene
mRNA/cDNA for SDHD Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (1371) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SDHD Gene
- Succinate dehydrogenase complex, subunit D, integral membrane protein:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SDHD
- GenScript: Design CRISPR guide RNA sequences for SDHD
miRNA Products
- Search ViGene Biosciences for SDHD
Clone Products
- Sino Biological Human cDNA Clone for SDHD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SDHD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SDHD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12218) for SDHD
Expression for SDHD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Bone (10.4) and Liver (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SDHD Gene
NURSA nuclear receptor signaling pathways regulating expression of SDHD Gene:
SDHDSOURCE GeneReport for Unigene cluster for SDHD Gene:
Hs.744039Primer Products
-
OriGene qPCR primer pairs and template standards for SDHD
-
OriGene qPCR primer pairs for SDHD
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SDHD Gene
Orthologs for SDHD Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SDHD 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SDHD 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SDHD 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sdhd 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Sdhd 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | SDHD 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sdhd 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sdhdb 34 35 |
|
||
| sdhda 35 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10219 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | sdhd-1 35 |
|
OneToMany |
- Species where no ortholog for SDHD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SDHD Gene
Paralogs for SDHD Gene
Pseudogenes.org Pseudogenes for SDHD Gene
Variants for SDHD Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs104894302 | Paragangliomas 1 (PGL1) [MIM:168000], Pathogenic | 112,089,002(+) | TCTTC(A/G/T)TGGTC | intron-variant, nc-transcript-variant, reference, missense | |
| rs104894304 | Paragangliomas 1 (PGL1) [MIM:168000], Pathogenic | 112,094,831(+) | TGACT(A/G)TGTTC | nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs202198133 | Mitochondrial complex II deficiency (MT-C2D) [MIM:252011], Pathogenic | 112,088,902(+) | CTAGC(A/G)AGAGG | intron-variant, nc-transcript-variant, reference, missense | |
| rs786205436 | Mitochondrial complex II deficiency (MT-C2D) [MIM:252011], Pathogenic | 112,088,972(+) | GATGG(A/G)CTATT | intron-variant, nc-transcript-variant, reference, missense | |
| rs80338844 | Paragangliomas 1 (PGL1) [MIM:168000], Pheochromocytoma (PCC) [MIM:171300], Pathogenic | 112,088,939(+) | GCTTC(C/T)GGCTG | intron-variant, nc-transcript-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2745077 | CNV | deletion | 23290073 |
| nsv975979 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.65;
31.55% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SDHD Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SDHD Gene
Disorders for SDHD Gene
(43) MalaCards diseases for SDHD Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| paragangliomas 1, with or without deafness |
|
|
| cowden syndrome 3 |
|
|
| mitochondrial complex ii deficiency |
|
|
| paraganglioma and gastric stromal sarcoma |
|
|
| hereditary paraganglioma-pheochromocytoma syndromes |
|
|
Search SDHD in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DHSD_HUMAN- Cowden syndrome 3 (CWS3) [MIM:615106]: A form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. {ECO:0000269 PubMed:18678321}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
- Intestinal carcinoid tumor (ICT) [MIM:114900]: A yellow, well-differentiated, circumscribed tumor that arises from enterochromaffin cells in the small intestine or, less frequently, in other parts of the gastrointestinal tract. {ECO:0000269 PubMed:12007193}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Mitochondrial complex II deficiency (MT-C2D) [MIM:252011]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome. {ECO:0000269 PubMed:24367056, ECO:0000269 PubMed:26008905}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]: Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. {ECO:0000269 PubMed:17804857}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Paragangliomas 1 (PGL1) [MIM:168000]: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. PGL1 is a rare autosomal dominant disorder which is characterized by the development of mostly benign, highly vascular, slowly growing tumors in the head and neck. In the head and neck region, the carotid body is the largest of all paraganglia and is also the most common site of the tumors. {ECO:0000269 PubMed:10657297, ECO:0000269 PubMed:11343322, ECO:0000269 PubMed:11391796, ECO:0000269 PubMed:11391798, ECO:0000269 PubMed:15328326}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. {ECO:0000269 PubMed:11156372, ECO:0000269 PubMed:12000816, ECO:0000269 PubMed:15328326}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Relevant External Links for SDHD
No data available for Genatlas for SDHD Gene
Publications for SDHD Gene
- Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. (PMID: 15328326) Neumann H.P.H. … Eng C. (JAMA 2004) 3 4 22 46 64
- Germ-line mutations in nonsyndromic pheochromocytoma. (PMID: 12000816) Neumann H.P.H. … Eng C. (N. Engl. J. Med. 2002) 3 4 22 46 64
- Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas. (PMID: 19915015) Gaal J. … Dinjens W.N. (J. Clin. Endocrinol. Metab. 2010) 3 22 46 64
- Germinal mutations of RET, SDHB, SDHD, and VHL genes in patients with apparently sporadic pheochromocytomas and paragangliomas. (PMID: 20205103) Krawczyk A. … Jarzab B. (Endokrynol Pol 2010) 3 22 46 64
- Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD. (PMID: 19802898) Ricketts C.J. … Maher E.R. (Hum. Mutat. 2010) 3 22 46 64
Products for SDHD Gene
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- antibodies-online Antibodies for SDHD: See all 34
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- Cyagen custom Knockout/knockin (KOKI) mouse models for SDHD
- VectorBuilder custom plasmid, inducible vectors for SDHD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SDHD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SDHD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab