SDHD Gene
protein-coding GIFtS: 61
GCID: GC11P111991
|
|
succinate dehydrogenase complex, subunit D, integral membrane...
(Previous symbols: PGL, PGL1)
| |
Aliases
for SDHD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein1 2 | | SDH42 3 | | PGL11 2 5 | | CBT12 | | PGL1 2 | | CybS3 | | Succinate-Ubiquinone Oxidoreductase Cytochrome B Small Subunit2 3 | | Succinate Dehydrogenase [Ubiquinone] Cytochrome B Small Subunit, Mitochondrial2 | | Succinate-Ubiquinone Reductase Membrane Anchor Subunit2 3 | | CybS3 | | CII-42 3 | | Succinate Dehydrogenase Complex Subunit D3 | | QPs32 3 | | |
Export aliases for SDHD gene to outside databasesPrevious GC identifers: GC11P114310 GC11P113469 GC11P111495 GC11P111462 GC11P107881 |
Summaries
for SDHD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SDHD:
This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate.The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of themitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditaryparaganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that thislocus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternativesplicing results in multiple transcript variants. (provided by RefSeq, Feb 2013)
UniProtKB/Swiss-Prot: DHSD_HUMAN, O14521Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of themitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone(coenzyme Q) (By similarity)
Gene Wiki entry for SDHD
|
Genomic Views
for SDHD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SDHD gene promoter:
FOXD3 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Tal-1beta AREB6 RORalpha1 Nkx6-1 Pax-4a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SDHD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDHD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23SDHD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P111991: view genomic region
(about GC identifiers)
Start:
|
111,957,497 bp from pter |
End:
|
111,990,353 bp from pter |
Size:
|
32,857 bases |
Orientation:
|
plus strand |
|
Proteins
for SDHD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DHSD_HUMAN, O14521 (See
protein sequence)Recommended Name: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor Size: 159 amino acids; 17043 Da
Subunit: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB,and a cytochrome b560 composed of SDHC and SDHD
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: A6ND90 B3KQQ8 Q53XW5 Q6IRW2Explore the universe of human proteins at neXtProt for SDHD: NX_O14521
SDHD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001263432.1 NP_001263433.1 NP_001263435.1 NP_002993.1
ENSEMBL proteins: ENSP00000364699 ENSP00000435475 ENSP00000436217 ENSP00000432465 ENSP00000432005 ENSP00000436669 ENSP00000432946 ENSP00000433202 Reactome Protein details: O14521
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SDHD for ontologies About GeneDecksing
SDHD Antibody Products:
Assay Products for SDHD: |
Protein
Domains /
Families
for SDHD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SDHD for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O14521ProtoNet protein and cluster: O14521 1 Blocks protein family: IPB007992 CybS
UniProtKB/Swiss-Prot: DHSD_HUMAN, O14521Similarity: Belongs to the CybS family |
Function
for SDHD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DHSD_HUMAN, O14521Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of themitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone(coenzyme Q) (By similarity) Genatlas biochemistry entry for SDHD:succinate dehydrogenase,cyb S subunit,liver,inner mitochondrial membrane,component 4 of complex II of mitochondrialrespiratory chain (CII-4),oxidative phosphorylation,(OXPHOS),also catalyzing the seventh step of the citric acid cycle
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDHD (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDHD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SDHD (NM_003002) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDHD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDHD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDHD |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SDHD for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SDHD:
Animal Models:
Mouse knock-out Sdhdtm1Jlob for SDHD
11 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Sdhd):
SDHD for phenotypes About GeneDecksing
|
Pathways & Interactions
for SDHD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | TCA Cycle | | | 3 | Metabolism | | | 4 | TCA cycle II (eukaryotic) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for SDHD
5/6 
Reactome Pathways for SDHD (see all 6)
5/6 
Kegg Pathways (Kegg details for SDHD) (see all 6):
UniProtKB/Swiss-Prot: DHSD_HUMAN, O14521Pathway: Carbohydrate metabolism; tricarboxylic acid cycle
SDHD for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SDHD
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/21 Interacting proteins for SDHD (O145213 ENSP000003646994) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006099 | tricarboxylic acid cycle |
TAS | -- | | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone |
IEA | -- | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
SDHD for ontologies About GeneDecksing
|
Drugs & Compounds
for SDHD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SDHD for compounds About GeneDecksing
 Browse Tocris compounds for SDHD
9 HMDB Compounds for SDHD About this table
4 DrugBank Compounds for SDHD About this table
7 Novoseek chemical compound relationships for SDHD gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| succinate |
92.2 |
84 |
16080530 (2), 11404820 (1), 12782822 (1), 12811540 (1) (see all 74) |
| mibg |
67.4 |
1 |
17898811 (1) |
| fumarate |
60.2 |
3 |
19573790 (1), 16327764 (1), 18728283 (1) |
| catecholamine |
51.5 |
1 |
17227803 (1) |
| ubiquinone |
51 |
1 |
15989954 (1) |
| iron-sulfur |
48.2 |
3 |
11692162 (1), 15989954 (1), 16288654 (1) |
| oxygen |
8.79 |
5 |
12811540 (2), 19768395 (1), 17487275 (1), 17376234 (1) |
Search CenterWatch for drugs/clinical trials and news about SDHD / DHSD
|
Transcripts
for SDHD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SDHD gene (4 alternative transcripts): NM_001276503.1 NM_001276504.1 NM_001276506.1 NM_003002.3 Unigene Cluster for SDHD: Succinate dehydrogenase complex, subunit D, integral membrane protein Hs.744039 [show with all ESTs]Unigene Representative Sequence: BF2407278 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375549(uc001pmz.3) ENST00000528182 ENST00000528048 ENST00000528021
ENST00000526592 ENST00000525291 ENST00000530923 ENST00000534010
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDHD (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDHD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SDHD (NM_003002) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDHD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDHD |
Additional cDNA sequence: AB006202.1 AK075360.1 BC005263.1 BC009574.1 BC012603.1 BC015188.1 BC015992.1 BC022350.1 BC070307.1 BC071755.1 BC071756.1 BT007238.1 CR456932.1 24/31 DOTS entries (see all 31): DT.92472464 DT.92472520 DT.102843291 DT.92472459 DT.100863770 DT.95280165 DT.100863783 DT.120733756 DT.120733813 DT.92472499 DT.100863779 DT.120733902 DT.121396544 DT.100863778 DT.120733779 DT.121100864 DT.100039225 DT.100863769 DT.100863776 DT.100863781 DT.120733736 DT.120733740 DT.120733796 DT.120733817 24/1371 AceView cDNA sequences (see all 1371): BQ962548 BG024667 BU839269 BG403639 AA315473 BE207116 AL561498 BM758814 BQ938179 T24605 AB096252 BG501431 BE252963 AX747181 AA303046 BU660434 BE905245 BQ083930 BM272428 AA306311 CK002387 BM922264 BM827899 CB054080
GeneLoc Exon Structure
|
Expression
for SDHD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SDHD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAAACT
About this image
See SDHD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SDHD
SOURCE GeneReport for Unigene cluster: Hs.744039
SABiosciences Expression via Pathway-Focused PCR Arrays including SDHD:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDHD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDHD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDHD | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDHD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDHD |
Orthologs
for SDHD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SDHD gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SDHD1 |
succinate dehydrogenase complex, subunit D, integral more |
63.5(n)
66.42(a) |
|
419793 NM_001006321.1 NP_001006321.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SDHD6 |
-- |
83(a) |
1 → many |
GL343973.1(62978-65730) |
zebrafish
(Danio rerio) |
Actinopterygii |
CB361274.12 |
-- |
77.09(n) |
|
CB361274.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG102191 |
CG10219 |
47.84(n)
37.04(a) |
|
42808 NM_142924.2 NP_651181.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
sdhd-16 |
Putative succinate dehydrogenase [ubiquinone] cyto... |
34(a) |
1 → many |
II(11049086-11051695) |
ENSEMBL Gene Tree for SDHD (if available)
TreeFam Gene Tree for SDHD (if available) |
Paralogs
for SDHD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SDHD gene
- ENSG000002552922
SDHD for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for SDHD (see all 6)
PGOHUM00000234863 PGOHUM00000240819 PGOHUM00000241031 PGOHUM00000258152 PGOHUM00000258163
|
Genomic Variants
for SDHD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SDHD (111957497 - 111990353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SDHD: --
Human Gene Mutation Database (HGMD): SDHD
Locus Specific Mutation Databases (LSDB): SDHD
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDHD |
|
Disorders
/ Diseases
for SDHD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SDHD for disorders About GeneDecksing
OMIM gene information: 602690
OMIM disorders: 168000 171300 114900 606864 612359
UniProtKB/Swiss-Prot: DHSD_HUMAN, O14521
Defects in SDHD are a cause of paragangliomas type 1 (PGL1) [MIM:168000]. A neural crest tumor usually derivedfrom the chromoreceptor tissue of a paraganglion. PGL1 is a rare autosomal dominant disorder which is characterized bythe development of mostly benign, highly vascular, slowly growing tumors in the head and neck. In the head and neckregion, the carotid body is the largest of all paraganglia and is also the most common site of the tumors Defects in SDHD are a cause of susceptibility to pheochromocytoma (PCC) [MIM:171300]. Acatecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinalsymptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may bepersistent or intermittent Defects in SDHD may be a cause of susceptibility to intestinal carcinoid tumor (ICT) [MIM:114900]. A yellow,well-differentiated, circumscribed tumor that arises from enterochromaffin cells in the small intestine or, lessfrequently, in other parts of the gastrointestinal tract Defects in SDHD are a cause of paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]; also calledCarney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominantmanner, alone or as a component of a syndrome associated with other tumors, such as in the context ofneurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibilityto the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance Defects in SDHD are a cause of Cowden-like syndrome (CWDLS) [MIM:612359]. Cowden-like syndrome is a cancerpredisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus
20/55  diseases for SDHD (see all 55): About MalaCardsparagangliomas, familial nonchromaffin, 1, with or without deafness paraganglioma von hippel-lindau disease carney triad
multiple endocrine neoplasia cowden-like syndrome merkel cell carcinoma, somatic cranial nerve palsy
hereditary paraganglioma-pheochromocytoma syndromes carotid body tumor mitochondrial complex ii deficiency carcinoid tumors, intestinal
cerebellopontine angle tumor human immunodeficiency virus infectious disease neural crest tumor merkel cell carcinoma
paraganglioma and gastric stromal sarcoma sensorineural hearing loss glomus tumor familial medullary thyroid carcinoma
6 diseases from the University of Copenhagen DISEASES database for SDHD:Paraganglioma Leprosy Phaeochromocytoma Hemangioma
Neurofibromatosis Gastric lymphoma 10/28 Novoseek disease relationships for SDHD gene (see all 28) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| paraganglioma |
97.5 |
214 |
11526495 (5), 15328326 (5), 15905695 (4), 17102086 (4) (see all 99) |
| pheochromocytoma |
93.1 |
173 |
15774781 (6), 11397905 (5), 17308434 (5), 19215943 (5) (see all 81) |
| von hippel-lindau disease |
86.1 |
10 |
16001332 (1), 12928344 (1), 17119341 (1), 19522823 (1) (see all 10) |
| carotid body tumor |
85.5 |
7 |
17041923 (1), 16249420 (1), 11391796 (1), 15602946 (1) (see all 7) |
| multiple endocrine neoplasia |
85.1 |
10 |
15788647 (1), 15531530 (1), 17102076 (1), 17102083 (1) (see all 10) |
| neurofibromatosis type 1 |
78.6 |
14 |
15788647 (1), 16001332 (1), 12928344 (1), 17102076 (1) (see all 13) |
| carney triad |
70 |
1 |
19522821 (1) |
| germ-line mutation |
68.3 |
13 |
17576205 (5), 11156372 (2), 19399650 (1), 10657297 (1) (see all 7) |
| glomus tumor |
61 |
2 |
12000816 (1), 17102085 (1) |
| multiple tumors |
59.7 |
4 |
16249420 (1), 16317055 (1), 15774781 (1) |
GeneTests: SDHD
Hereditary Paraganglioma-Pheochromocytoma Syndromes
Genetic Association Database (GAD): SDHD
Human Genome Epidemiology (HuGE) Navigator: SDHD (34 documents)
Export disorders for SDHD gene to outside databases
|
Publications
for SDHD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SDHD gene, integrated from 9 sources (see all 263):
(articles sorted by number of sources associating them with SDHD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. (PubMed id 15328326)1, 2, 4, 9 Neumann H.P.H.... Eng C. (2004)
- Germ-line mutations in nonsyndromic pheochromocytoma. (PubMed id 12000816)1, 2, 4, 9 Neumann H.P.H.... Eng C. (2002)
- Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23. (PubMed id 9533030)1, 2, 3 Hirawake H.... Kita K. (1997)
- Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma. (PubMed id 11156372)1, 2, 9 Gimm O.... Eng C. (2000)
- Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss. (PubMed id 11391796)1, 2, 9 Badenhop R.F....Schofield P.R. (2001)
- Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. (PubMed id 10657297)1, 2, 9 Baysal B.E.... Devlin B. (2000)
- Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. (PubMed id 11897817)1, 4, 9 Baysal B.E.... Rubinstein W.S. (2002)
- Germline SDHD mutation in paraganglioma of the spinal cord. (PubMed id 11526495)1, 2, 9 Masuoka J.... Ohgaki H. (2001)
- Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene. (PubMed id 11391798)1, 2, 9 Taschner P.E.M.... Devilee P. (2001)
- Characterization of the human SDHD gene encoding the small subunit of cytochrome b (cybS) in mitochondrial succinate-ubiquinone oxidoreductase. (PubMed id 10482792)1, 2, 9 Hirawake H.... Kita K. (1999)
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External Searches for SDHD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SDHD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SDHD gene
(According to HUGE)
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Specialized Databases showing SDHD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for SDHD | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for SDHD | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SDHD | | Wikipedia | http://en.wikipedia.org/wiki/SDHD | | TCA Cycle Gene Mutation Database | http://chromium.liacs.nl/LOVD2/SDH/home.php?select_db=SDHD |
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About This Section
| Patent Information for SDHD gene:
Search GeneIP for patents involving SDHD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SDHD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SDHD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDHD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDHD | | | OriGene Protein Over-expression Lysate for SDHD | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SDHD | | OriGene 3'-UTR Clone for SDHD | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDHD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDHD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SDHD | | OriGene Custom Protein Services for SDHD | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDHD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDHD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDHD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDHD | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDHD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDHD |
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| | | | Search Tocris compounds for SDHD |
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 | | | SDHD Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SDHD |
|  |  |  | | | | Search ThermoFisher Antibodies for SDHD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDHD |
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